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Chen­Yong Lin, Ph.D Curriculum Vitae

Chen­Yong Lin, Ph.D Associate Professor Department of Biochemistry and Molecular Biology Marlene and Stewart Greenebaum Cancer Center University of Maryland Contact Information Bressler Research Building 655 W. Baltimore Street, 10­027 Baltimore, MD 21201 USA Tel: 410­706­3261 E­mail: cylin@som.umaryland.edu Foreign Languages: Chinese (native), Taiwanese (native), English (fluent)

Education 1985, June Bachelor of Science in Agriculture National Taiwan University, Taipei, Taiwan, Major: Animal Science 1995, May

Ph.D. in Cell Biology Georgetown University, Washington DC Mentor: Wen­Tien Chen Dissertation Title: Cell Surface protease complexes on human microvessel endothelia: Identification, isolation, and biochemical characteristics.

Post Graduate Education and Training 1995-1997, Post-doctoral fellow Lombardi Cancer Center, Georgetown University Medical Center, Washington DC Mentor: Robert Dickson, Ph.D.

Employment History

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Chen­Yong Lin, Ph.D 2007-prsent

2003-2007

1999-2003

1997-1999

1990-1992 1987-1989

1985-1987

Associate Professor Department of Biochemistry and Molecular Biology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland Research Associate Professor Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington DC Research Assistant Professor Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington DC Research Associate Department of Oncology Lombardi Cancer Center, Georgetown University Medical Center, Washington DC Research Assistant Department of Cell Biology, Georgetown University, Washington DC Research Assistant Laboratory of Cell Biology, Institute of Biomedical Sciences, Academia Sinica, Taipei Taiwan Research Assistant Department of Botany, National Taiwan University, Taiwan

Professional Society Memberships 2003-present 2004-present

Member in International Proteolysis Society Regular member in the American Physiological Society

Honors and Awards 1988, August Travel grant to the International Conference of Cell Biology in Montreal Canada. Supported by Institute of Biomedical Sciences, Academia Sinica, Taipei Taiwan 1998, June Young Investigator Travel Grant to AACR Conference on Proteases and Protease Inhibitors in Cancer, Nyborg, Denmark.

Administrative Service Institutional Service Georgetown University:

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Chen­Yong Lin, Ph.D 2004-Present Oversight Committee for Macromolecular Analysis Shared Resource Local and National Service 2003 2004 2004 2005 2005 2005 2005 2005 2006 2006 2006 2006 2007 2007

Grant Reviewer, The Susan G. Komen Breast Cancer Foundation Ad Hoc Reviewer , The Journal of Pathology Grant Reviewer. The Susan G. Komen Breast Cancer Foundation Ad Hoc Reviewer, Experimental Cell Research Ad Hoc Reviewer, Journal of Proteome Research Ad Hoc Reviewer, Clinical Cancer Research Ad Hoc Reviewer, Journal of Proteome Research Ad Hoc Reviewer, Cell and Tissue Research Ad Hoc Reviewer, FEBS Letters Ad Hoc Reviewer, Biomed Central Cancer Ad Hoc Reviewer, Cellular and Molecular life Sciences Ad Hoc Reviewer, Biomarker Insights Ad Hoc Reviewer, Cancer Research Ad Hoc Reviewer, BBA

Teaching Service Lectures 2005 Lecturer Cancer Pharmacology Tumor Biology Program Course (TBIO­535) about 20 graduate students—1 hour/yr 2006 Lecturer Cancer Pharmacology Tumor Biology Program Course (TBIO­535) about 20 graduate students—1 hour/yr Mentoring Activities Post-Doctoral Fellows Training 1999­2003 Sheau­Ling Lee (Present position: Assistant Investigator Stem Cell Research Center, NHRI, Taiwan) 2001­2002 Christelle Benaund (Present position: Senior Scientist, CR­1, INSERM EMI 3

Chen­Yong Lin, Ph.D 104, CEA, Genoble, France) 2003.2006 Ming­Shyue Lee (Present position: Assistant Professor, Graduated Institute of Biochemistry and Molecular Biology, National Taiwan University, School of Medicine) Ph.D. Students 1999­2002 Michael Oberst (Post­doc fellow in NIH) 2005­present I­Chu Tseng 2006­present Phil Chou PhD Research Rotations (10 hrs/week for a semester) 1996 Jehng­Kang Wang (Department of Cell Biology) (Present position: Assistant Professor, Department of Biochemistry, National Defense Medical Center, Taiwan) 1997 Bin Xie (Tumor Biology Program) 1998 Angera H. Kuo (Tumor Biology Program) 1999 Leanne S. Sleer (Tumor Biology Program) 2005 I­Chu Tseng (Tumor Biology Program) 2006 Phil Chou (Tumor Biology Program) 2006 Rahul Ballal (Department of Biochemistry and Molecular Biology) MS Internship Students (10 hrs/week for a semester) 2005 Yun­Chun Chen (Biotechnology MS Program) 2005 Sean Lin (Biotechnology MS Program) (Present position: Ph.D student, University of Rochester, NY) 2006 Patty Su (Biotechnology MS Program) 2006 Bryan Chen (Biotechnology MS Program) 2007 Ya­Wen Chen (Tumor Biology MS Program) 2007 Tai­Shien Lee (Biotechnology MS Program) Summer Students (40 hrs/week for two months) Undergraduate 2002 Ruei­Jiun Hung (Present position: Ph. D. student, UT, Southwestern Medical School, TX) 2002 Ia­Wen J. Hsu (Present position: Ph.D. Student, University of Rochester, NY) 2003 Joan M. Lee 2003 Paige Walter

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Chen­Yong Lin, Ph.D 2005 Perry Tsai 2005 Chin­Che Chen High School 2005 Oliver Chang 2005 Ping Lin (Present position: Undergraduate student, Duke University) 2006 Amada Lucht

Grant Support Active 2003-2008

Chen­Yong Lin (PI, 40%)(Transfer from Dr. Robert B. Dickson, 2006) “Matriptase: Activation And Function in Breast Cancer” NIH RO1CA09685 Annual Direct Costs: $ 160,000 Total Direct Cost: $ 800,000 Total Indirect Cost: $441,600

2004-2009

Chen­Yong Lin (PI, 40%) “Deregulation of Matriptase in Breast Cancer Cell” NIH R01CA104944 Annual Direct Costs: $ 160,000 Total Direct Cost: $ 800,000 Total Indirect Cost: $441,600

2006-2008

Chen­Yong Lin (PI, in kind) “Deregulation of Matriptase in Breast Cancer Cell” NIH R01CA104944­03S1 (Supplemental Grant) Annual Direct Costs: $ 29,434 Total Direct Cost: $ 58,568 Total Indirect Cost: $32,330

Completed 2001-2003

Chen­Yong Lin (PI) “The anti­protease and anti­tumor activity of matriptase inhibitor in Breast Cancer” The Susan G. Komen Breast Cancer Foundation (BCTR0100345) Annual Direct Costs: $ 96,000 Total Direct Cost:$ 192,000 5

Chen­Yong Lin, Ph.D

2002­2005

2001-2005

Total Indirect Cost: $48,000 Chen­Yong Lin (PI) “Matriptase Activation in Breast Cancer” Department of Defense, IDEA Award (DAMD17­02­10391) Annual Direct Costs: $ 100,000 Total Direct Cost:$ 300,000 Total Indirect Cost: $165,600 Chen­Yong Lin (PI) “An Epithelial­derived, Integral Membrane, Kunitz­Type Serine Protease Inhibitor in Breast Cancer” Department of Defense, Career Development Award (DAMD17­01­0252) Annual Direct Costs: $ 63,000 Total Direct Cost: $ 252,000 Total Indirect Cost: $139,104

US and International Patents 1. Monoclonal antibody to an 80­kDa protease, Dickson, R.B., and Lin, C.-Y., Patent No. 6,077,938; Issue date 06/20/2000 2. Structure based discovery of inhibitors of matriptase for the cancer diagnosis and therapy by detection and inhibition of matriptase activity, Dickson, R.B., Lin, C.-Y., Wang, S., Enyedy, I., Lee, S.­L., Patent No. 6,677,377; Issued Date 01/13/2004

Publications Peer- reviewed Journal Articles 1. Tang, T.K., Hong, T.M., Lin, C.­Y., Lai, M.L., Liu, C.H., Lo, H.J., Wang, M.E., Chen, L.B., Chen, W.T., and Ip, W., (1993). Nuclear proteins of the bovine esophageal epithelium. i. monoclonal antibody w2 specifically reacts with condensed nuclei of differentiated superficial cells. J. Cell Sci. 104, 237­247.

2. Monsky, W.L., Kelly, T., Lin, C.­Y., Yeh, Y., Stetler­Stevenson, W.G., Mueller, S.C., and Chen, W.T. (1993). Binding and localization of m(r) 72,000 matrix metalloproteinase at cell surface invadopodia. Cancer Res. 53, 3159­3164.

3. Monsky, W.L., Lin, C.­Y., Aoyama, A., Kelly, T., Akiyama, S.K., Mueller, S.C., and Chen, W.T. (1994). A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells. Cancer Res. 54, 5702­5710.

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Chen­Yong Lin, Ph.D 4. Chen, W.T., Lee, C.C., Goldstein, L., Bernier, S., Liu, C.H., Lin, C.­Y., Yeh, Y., Monsky, W.L., Kelly, T., and Dai, M. (1994). Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy. Breast Cancer Res. Treat. 31, 217­226.

5. Lin, C.­Y., Wang, J.­K., Torri, J., Dou, L. Sang, Q.­X. A. and Dickson R. B. (1997) Characterization of a novel, membrane­bound 80­kDa matrix­degrading protease from human breast cancer cells: monoclonal antibody production, isolation, and localization.

J. Biol. Chem. 272: 9147­9152.

6. Lin, C.­Y., Anders, J., Johnson, M., Sang, Q. A., and Dickson, R.B. (1999) Molecular cloning of cDNA for matriptase, a matrix­degrading serine protease with trypsin­like activity. J. Biol. Chem. 274: 18231­18236.

7. Lin, C.­Y., Anders, J., Johson, M., and Dickson, R.B. (1999) Purification and Characterization of a complex containing matriptase and a Kunitz­type serine protease inhibitor from human milk. J. Biol. Chem. 274: 18237­18242.

8. Lee, S.­L., Dickson, R.B., and Lin, C.­Y., (2000) Activation of urokinase and hepatocyte growth factor by matriptase, an epithelial membrane­bound serine protease. J. Biol.

Chem. 275: 36720­36725.

9. Benaud C., Dickson R.B., and Lin, C.­Y., (2001) Regulation of the activity of matriptase on epithelial cell surfaces by a blood­derived factor. Eur. J. Biochem. 268: 1439­1447.

10. Oberst, M., Anders, J., Xie, B., Singh, B., Ossandson, M., Johnson, M., Dickson R.B., and Lin, C.­Y., (2001) Matriptase and HAI­1 are expressed by normal and malignant epithelial cells in vitro and in vivo. American J. Path. 158: 1031­1311.

11. Enyedy, I.J., Lee, S.­L., Kuo, A.H., Dickson, R.B., Lin, C.­Y., and Wang, S., (2001) Structure­based Approach for the discovery of bis­benzamidines as novel inhibitors of matriptase. J. Med. Chem. 44: 1349­1355.

12. Long, Y.­Q, Lee, S.­L., Lin, C.­Y., Enyedy, I.J., Wang, S., Dickson, R.B., and Roller, P.P., (2001) Synthesis and Evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. Bioorg. & Medicinal Chem. Lett. 17:2515­2519.

13. Benaund, C., Oberst, M., Hobson, J.P., Spiegel, S., Dickson R.B., and Lin, C.­Y., (2002) Sphingosine 1­phosphate, present in serum lipoproteins, activates matriptase. J. Biol.

Chem. 277: 10539­10546.

14. Oberst, M.D., Johnson, M.D., Dickson, R.B., Lin, C.­Y., Singh, B., Stewart, M., williams, A., al­Nafussi, A., Smyth, J.F., Gabra, H., and Sellar, G.C., (2002) Expression of the Serine Protease Matriptase and its Inhibitor HAI­1 in Epithelial Ovarian Cancer: Correlation with Clinical Outcome and Tumor Clinicopathological Parameters. Clinical Cancer Research, 8:1101­1107.

15. Ihara, S., Miyoshi, E., Ko, J.H., Murata, K., Nakahara, S., Honke, K., Dickson, R.B., Lin, C.­Y., and Taniguchi, N., (2002) Pro­metastatic effect of N­ acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1­6 GlcNAc­branching. J. Biol. Chem. 277:16960­16967.

16. Benaud, C., Oberst, M., Dickson, R.B., and Lin, C.­Y., (2002) Deregulated activation of matriptase in breast cancer cells. Clinical & Experimental Metastasis, 19:639­649.

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Chen­Yong Lin, Ph.D 17. Kang, J.Y., Dolled­Filhart, M., Ocal, T., Singh, B., Lin, C.­Y., Dickson, R.B., Rimm, D.L., and Camp, R.L., (2003) Tissue microarray analysis of HGF/Met pathway components reveals a role for met, matriptase, and HAI­1 in the progression of node­ negative breast cancer. Cancer Research, 63:1101­1105.

18. Oberst, M.D., Singh, B., Ozdemirli, M., Dickson, R.B., Johnson, M.D., and Lin, C.­Y. (2003) Characterization of Matriptase Expression in Normal Human Tissues. J. Histochem. and Cytochem. 51:1017­1025 19. Oberst, M.D., Williams, C., Johnson, M.D., Dickson, R.B., and Lin, C.­Y. (2003) The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. J. Biol. Chem. 278:26773­26779.

20. Ihara S, Miyoshi E, Nakahara S, Sakiyama H, Ihara H, Akinaga A, Honke K, Dickson RB, Lin C.­Y., Taniguchi N. (2004) Addition of β1­6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin. Glycobiology 14:139­146.

21. Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin C.­Y., Dickson RB, Terao T. (2004) Inhibition of tumor invasion by genomic downregulation of matriptase through suppression of activation of receptor­bound pro­urokinase. J. Biol. Chem.

279:14899­908.

22. Hung RJ, Hsu I. W., Dreiling J. L., Lee M. J., Williams C. A., berst M. D., Dickson R. B., and Lin C.­Y. (2004) Assembly of Adherens Junctions Is Required for Sphingosine 1­phosphate­induced Matriptase Accumulation And Activation at Mammary Epithelial Cell­cell Contacts. Am J Physiol Cell Physiol. 286:C1159­69.

23. Lee M.­S., Kiyomiya K., Benaud C., Dickson R.B., and Lin C.­Y. (2005) Simultaneous activation and HAI­1­mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. Am J Physiol Cell Physiol. 288:C932­C941.

24. Lee, J.­W., Choi, J.­J., Song, S.Y., Lee, S.­J., Kim, B.­G., Park, C.­S., Lee, J.­H., Lin, C.­ Y., Dickson, R.B., and Bae, D.­S. (2005) Increased Expression of Matriptase during Progression of Cervical Neoplasia. Human Pathology 36:626­33.

25. Oberst MD, Chen LY, Kiyomiya KI, Williams CA, Lee MS, Johnson MD, Dickson RB, Lin C.­Y. (2005) HAI­1 regulates activation and expression of matriptase, a membrane­ bound serine protease. Am J Physiol Cell Physiol. 289:C462­470.

26. Jin, X., Hirosaki, T., Lin, C.­Y., Dickson, R. B., Higashi, S., Kitamura, H., and Miyazaki, K. (2005) Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin. J Cell Biochem. 95, 632­647 27. Siddiqui S.F., Pawelek J., Handerson T., Lin C.­Y., Dickson R.B., Rimm D.L. and Camp R.L. (2005) Coexpression of β1,6­N­Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome. Cancer Epidemiol Biomarkers Prev 14: 2517­2523.

28. Ahmed S., Jin X., Yagi M., Yasuda C., Sato Y., Higashi S., Lin C.­Y., Dickson R.B., and Miyazaki K. (2006) Identification of membrane­bound serine proteinase matriptase as processing enzyme of insulin­like growth factor binding protein­related protein­1 (IGFBP­rP1/angiomodulin/mac25). FEBS J 273: 615­627.

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Chen­Yong Lin, Ph.D 29. Ito Y., Akinaga A., Yamanaka K., Nakagawa T., Kondo A., Dickson R.B., Lin C.­Y., Miyauchi A., Taniguchi N., and Miyoshi E. (2006) Co­expression of matriptase and N­ acetylglucosaminyltransferase V in thyroid cancer tissues; its possible role in prolonged stability in vivo by aberrant glycosylation. Glycobiology 16:368­374 30. Saleem M., Adhami V.M., Zhong W., Longley B.J., Lin C.­Y., Dickson R.B., Reagan­ Shaw S., Jarrard D.F., Mukhtar H. (2006) A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor­1. Cancer Epidemiol Biomarkers Prev 15:217­227 31. Kiyomyia, K., Lee, M., Tseng I.C., Zuo H., Barndt R.J., Johnson M.D., Dickson R.B., and Lin, C.­Y. (2006) Matriptase activation and subsequent shedding with HAI­1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells. Am J Physiol Cell Physiol 291:C40­C49.

32. Netzel­Arnett, S., Currie, B. M., Szabo, R., Lin, C.­Y., Chen, L. M., Chai, K. X. Antalis, T. M., Bugge, T. H., and List, K. (2006) Evidence for a matriptase­prostasin proteolytic cascade regulating terminal epidermal differentiation. J. Biol. Chem. 281(44):32941­5.

33. Jin, X., Yagi M., Akiyama, A., Hirosaki, T., Higashi, S., Lin, C.­Y., Dickson, R.B., Kitamura, H., and Miyazaki, K. (2006) Matriptase activates stromelysin (MMP­3) and promotes tumor growth and angiogenesis. Cancer Sci. 97(12):1327­34.

34. Jiang, S., Li, P., Lee,S.­L., Lin, C.­Y., Long, Y.­Q., Johnson, M.D., Dickson, R.D., and Roller,P.P., (2007) Design and Synthesis of Redox Stable Analogues of Sunflower Trypsin Inhibitors (SFTI­1) on Solid Support, Potent Inhibitors of Matriptase. Org. Lett.

9(1) pp 9 ­ 12; (letter) 35. Oo, ML., Thangada, S., Wu, M.T., Liu, C.H., Macdonald, T.L., Lynch, K.R., Lin, C.Y., and Hla, T. (2007) Immunosuppressive and anti­angiogenic sphingosine 1­phosphate receptor­1 (S1P1) agonists induce ubiquitinylation and proteosomal degradation of the receptor. J. Biol. Chem. 282:9082-9089.

36. Lee M­S, Tseng I­C., Wang Y., Kiyomiya K, Dickson RB, and Lin C.­Y. (2007) Activation of matriptase in vitro: requirement for biomembrane and LDL receptor domain. Am J Physiol Cell Physiol (in press).

37. Chen, M., Fu, Y.­Y., Lin, C.­Y., Chen, L.­M., and Chai, K. X. (2007) Prostasin induces protease­dependent and independent molecular changes in the human prostate carcinoma cell line PC­3. Biochim Biophys Acta (EPub)

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Chen­Yong Lin, Ph.D Book Chapters and Reviews 1. Oberst, M., Johnson, M., Dickson and Lin, C.­Y. (2002). The Transmembrane Serine Protease Matriptase And Its Inhibitor HAI­1: Implications for Cellular Biology And Human Cancer, pp. 169­190. In Recent Research Developments in Biochemistry, Research Signpost.

2. Johnson, M.D., Oberst, M.D., Lin, C.­Y., and Dickson, R.D., (2003) Possible role of matriptase in the diagnosis of ovarian cancer. Expert Rev. Mil. Diagn. 3:331­338.

3. Lin, C.­Y., Oberst, M., Johnson, M., and Dickson, R.B. (2004). Matriptase. In Handbook of Proteolytic Enzymes, 2nd Edition, pp. 1559­1561, Academic Press.

Gene Sequences Published by NCBI/NI H Genebank 1. Lin, C.-Y., Anders, J., Johson, M., Sang, Q. A., and Dickson, R.B. (1999) Molecular cloning of cDNA for matriptase, a matrix­degrading serine protease with trypsin­like activity. ACCESSION # AF118224

Major Invited Speeches 1998 June Proteases and Protease Inhibitors in Cancer Conference, Nyborg , Denmark.

“A Novel Membrane­bound, Trypsin­Like Protease and Its Cognate Kunitz­Type Inhibitor in Human Carcinomas”.

2001 May Institution of Biomedical Science, Academia Sinica, Taipei, Taiwan “The Biology and biochemistry of matriptase/AHI­1 system: an epithelialderived, integral membrane serine protease/Kuniz­type inhibitor system in cancer invasion and metastasis” 2001 May Department of Biochemistry, Osaka University, Osaka, Japan “Disregulation of matriptase, a mammary epithelial membrane serine protease in breast cancer progression” 2003 Feb. Department of Cell Biology and Anatomy, Louisiana State University in Shreveport, Health Sciences Center “Dysregulation of Matriptase, a Cell Surface Protease of Carcinoma cells” 2004 July National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD “Cell Surface Proteolysis in Human Cancer: Matriptase and HAI­1”

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Chen­Yong Lin, Ph.D 2004 August Department of Pathology, Wayne State University, Detroit “Cell Surface Proteolysis in Human Cancer: Matriptase and HAI­1” 2005 April Xth International Workshop on Molecular & Cellular Biology of Plasmonogen Activation. Washington DC “Hepatocyte Growth Factor Activator Inhibitor 1 (HAI­1): Role in Matriptase Function beyond a Conventional Inhibitor” 2006 May Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan “Matriptase and HAI­1: A New Type of Oncogen­Suppressor Gene Partnership” 2006 May Department of Biochemistry, Osaka University, Osaka, Japan “Deregulation of matriptase in human cancers”

Poster Presentations 1. Lin, C.­Y., Lai, M.L., Liu, C.H., Lo, H.J., Wang, M.E., Chen, L.B., Chen, W.T., Ip, W., and et al (1992). Characterization of nuclear antigen W2 of the bovine esophageal epithelium to be a terminal differentiation marker. International Conference of Cell Biology, Montreal, Canada 2. Lin, C.Y., Jehng­Kang Wang, Jeff Torri, Li Dou, and Robert B. Dickson, (1996).

Characterization of an 80­kDa matrix­degrading protease as a novel, membrane­bound gelatinase. Proteases and Protease Inhibitors, an AACR Special Conference.

3. Lin, C.­Y, Wang, J.­K., Torri, J., Dou, L., and Dickson R. B. (1996). Purification of a novel, membrane­bound 80­kDa matrix­degrading protease, Annual NIH SPORE Meeting, Rockville, MD, 1996.

4. Lin C.­Y., and Dickson, R.B. (1997). Differential expression of an extracellular matrix­ degrading 80­kDa protease in resting, lactating, and neoplastic mammary gland. Breast Development Physiology and Cancer, NIH, Bethesda, MD. 5. Lin C.­Y., Thomas, D., Noriss, B.M., Anders, J., Johnson, M., and Dickson, R.B. (1998) A novel membrane­bound, trypsin­like protease and its cognate Kunitz­type inhibitor in human carcinomas. Proteases and Protease Inhibitors in Cancer, an AACR and APMIS Special Conference, Nyborg, Denmark.

6. Oberst, M., Johnson, M., Anders, J., Dickson, R.B., and Lin, C.­Y. (2000) Full length cloning of the serine protease matriptase and characterization of its expression in breast cancer primary tumors, metastases, and cell lines. AACR, 91st annual meeting, San Francisco, CA 7. Lee, S.­L., Dickson, R.B., and Lin, C.­Y. (2000) Biological functions of matriptase, a novel trypsin­like protease. FACS/The Salk Institute for biological studies. 16th annual meeting on oncogenes and tumor suppressors: The evolution of the cancer cell

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Chen­Yong Lin, Ph.D 8. Benaud, C., Dickson, R.B., and Lin, C.­Y., (2001) Regulation of the activity of matriptase on epithelial cell surfaces by a blood­derived factor. Cold Spring Harbor Meeting on Proteolysis & Biological control. Cold Spring Harbor, New York 9. Parker, C.J., Vreeke, M., Lin, C.­Y., and Dickson, R.B., (2001) Analysis of gene expression in a B cell neoplasm with phenotype of a primary effusion lymphoma (PEL).

Annual Meeting of the American Society of Hematology.

10. Oberst, M.D., Anders, J., Benaud, C., Lin, C.­Y., Dickson, R.D., and Johnson, M.D., (2001) Over­expression of the hepatocyte growth factor inhibitor (HAI­1) in human breast cancer cells: Effects on cell growth, morphology, and motility. 2nd General Meeting of International Protease Society, Muenchen, German.

11. Benaud, C., Oberst, M., Dickson, R.B., and Lin, C.­Y., (2001) Differential regulation of matriptase activation in human mammary epithelial cells and breast cancer cells. 2nd General Meeting of International Protease Society, Muenchen, German.

12. Roller, P.P., Long, Y.­Q., Li, P., Lee, S.­L., Lin, C.­Y., Enyedy, I., Wang, S., Dickson, R.B. (2001) Bicyclic Peptide inhibitors of an epithelial cell­derived transmembrane protease, matriptase. In Peptides: The Wave of the Future (Proceedings of the 2nd International/17th American Peptide Symposium), Lebl. M and Houghten, R.A. (Eds), American Peptide Society, San Diego, CA. pp 561­562 13. Oberst, M.D., Anders, J., Lin, C.­Y., Dickson, R.D., and Johnson, M.D., (2002) Over­ expression of the hepatocyte growth factor inhibitor (HAI­1) in human MCF­7 breast cancer cells: Effects on cell growth, morphology, and motility. Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Orlando, Florida.

14. Oberst, M.D., Anders, J., Dickson, R.D., Johnson, M.D., and Lin, C.­Y., (2002) Expression of the hepatocyte growth factor inhibitor (HAI­1) in MDA MB­435 human breast cancer cells reduces growth in vitro and in vivo. Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Orlando, Florida.

15. Lee, S.­L., Lin, C.­Y., and Dickson, R.D., (2002) Matriptase , a novel type­2 membrane serine protease, is an activator of hepatocyte growth factor and pro­uPA. Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Orlando, Florida.

16. Lee, S.­L., Benaud, C., Enyedy, I.J., Long, Y­Q., Wang, S., Roller, P.P., Dickson, R.D., and Lin, C.­Y., (2002) Small­molecule and peptide inhibitors of matriptase in breast cancer cells. Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Orlando, Florida.

17. Williams, C., Benaud, C., Oberst, M.D., Dickson, R.B., and Lin, C.­Y., (2002) Deregulation of matriptase activity in breast cancer cells. Proteases, Extracellular Matrix, and Cancer. AACR­Special Conference in Cancer Research, Hilton Head Island, South Carolina 18. Hung, R.­J., Hsu, I.­W. J., Dreiling, J.L., Williams, C.A., Oberst, M., Dickson, R.B., and Lin, C.­Y., (2003) Sphingosine 1­phosphate induces translocation and activation of matriptase at mammary epithelial cell­cell contacts: FASEB Summer Research Conferences: Lysophospholipids and Related Lipids in Biology and Diseases, Snowmass, Colorado.

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Chen­Yong Lin, Ph.D

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