Xiaochun Chen, Ph.D. Research associate xiachen@som.umaryland.edu
Education: Research Interests
Publications
PhD Biomedical Engineering. Zhejiang University, P.R.China 2001 M.S. Pharmacology, China Pharmaceutical University, P.R.China 1998 Using chemical, biological and genetic tools to identify and manipulate molecular mechanisms of HSC proliferation, cell fate determination, and differentiation and to discover new drugs for clinics as well. Ongoing projects includes screening compounds a) affecting micro RNA function, b) affecting HSC cell type commitment and c) inhibiting leukemia stem cell proliferation. Collaborative project with other groups in Johns Hopkins includes the discovery of novel antiproliferation agents for leukemia using both in vitro cell culture and our recently developed in vivo mice model. 1. Chen X , Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009; 16(2):193202. 2. Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH. MalariaInfected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells. J Med Chem. 2009; 52 (4), 1198–1203. 3. Hu X.V., Chen X, Han K.C., Mildvan A.S., Liu J.O. Kinetic and Mutational Studies of the Number of Interacting Divalent Cations Required by Bacterial and Human Methionine Aminopeptidases. Biochemistry. 2007; 46(44): 1283312843. 4. Chen X , Chong C. R., Shi L., Yoshimoto T., Sullivan D. J. Jr., Liu J.O. From the Cover: Inhibitors of Plasmodium falciparum Methionine Aminopeptidase 1b Possess Antimalarial Activity. Proc Natl Acad Sci U S A.2006; 103(39): 1454814553. 5. Chong C. R., Chen X, Shi L., Liu J.O. Sullivan D. J. Jr., A clinical drug library screen identifies astemizole as an antimalarial agent. Nat Chem Biol. 2006; 2(8): 415416. 6. Maldve RE, Chen X, Zhang TA, Morrisett RA. Ethanol selectively inhibits enhanced vesicular release at excitatory synapses: realtime visualization in intact hippocampal slices. Alcohol Clin Exp Res. 2004; 28(1): 143152. 7. Xu Q, Chen X. CD4 T lymphocytes cause hepatocyte apoptosis by releasing Th1 cytokines in cellular immunological liver injury. Inflammation Res. 2002; 51(9): 444450.
8. Chen X , Sheng C, Zheng X. Direct nitric oxide imaging in cultured hippocampal neurons with diaminoanthraquinone and confocal microscopy. Cell Biology International. 2001; 25(7): 593598. 9. Chen X , Sheng C, Zheng XX. Inhibitive Effect of NnitroLarginine on Hippocampal Neurons Excitation. Acta Biochimica et Biophysica Sinica. 2001; 33(4): 437442. 10. Chen X , Sheng C, Zheng XX. Inhibitive Effect of Nitric Oxide on Hippocampal Neurons Excitation. Acta Biophysica Sinica 2001; 17(3): 469476. 11. Chen X , Cao J and Xu Q. Endotoxin exacerbates the immunological liver injury in the cooperation of interferonγ . Inflammation Res 2000; 49: 571577. 12. Cao J, Lu J, Wu F, Cheng X, Xu Q. Effects of several drugs on the liver injury induced by delayedtype hypersensitivity to picryl chloride by regulating suppressor or helper T cells. Pharmacol Res. 1999; 39(2): 97102. 13. Xu Q, Wu F, Jiang J, Lu J, Chen X and Zhang B. Role of CD4+ and CD8+ T cells in regulating the chronic development of liver injury induced by delayedtype hypersensitivity to picryl chloride. Int Arch Allergy Immunol 1998; 116: 154164. 14. Xu Q, Lu J, Wang R, Wu F, Cao J, and Chen X. Liver injury model induced in mice by a cellular immunologic mechanism – study for use in immunopharmacological evaluations. Pharmacol Res, 1997; 35: 273276.