W en-Chih Cheng, PhD Post-Doctoral Fellow wcheng@som.umaryland.edu Education
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Research Interests
BS in Zoology from National Taiwan University Ph.D. in Molecular Microbiology and Immunology at Johns Hopkins Bloomberg School of Public Health
My two main projects focus on (1) the role of Hippo signaling pathway in regulation of hematopoietic stem-progenitor cells and (2) identification and characterization of microRNA species that are master regulators in human hematopoiesis.
Laboratory Experiences
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Maternal effects on embryonic development in Drosophila (1998) Epstein Barr Virus Biology (1999-2001) Yeast Genetics and Genomics (2001-2008) Programmed Cell Death, e.g. apoptosis (2001-2008) Mitochondria biology, specifically in dynamics and metabolism (2001-2008)
Publications
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Cheng W C, Teng X, Park HK, Tucker CM, Dunham MJ and Hardwick JM (2008). Fis1-deficiency Selects for Compensatory Mutations Responsible for Cell Death and Growth Control Defects. Cell Death & Diff. 15(12):1838-46
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Cheng W C, Leach KM, Hardwick JM (2008). Mitochondrial fission during yeast and mammalian cell death. Biochim Biophys Acta. 1783(7):1272-9.
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Cheng W C, Hardwick JM. (2007). A quorum on bacterial programmed cell death. Mol Cell. 28(4):515-517.
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Chen YB, Seo SY, Kirsch DG, Sheu TT, Cheng W C, and Hardwick JM (2006). Alternate functions of viral regulators of cell death. Cell Death Differ. 13, 1318-1324.
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Cheng W C, Berman SB, Ivanovska I, Jonas EA, Lee SJ, Chen Y, Kaczmarek LK, Pineda F, and Hardwick JM (2006). Mitochondrial factors with dual roles in death and survival. Oncogene 25, 4697-4705.
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Hardwick JM, and Cheng W C (2004). Mitochondrial programmed cell death pathways in yeast. Dev. Cell. 7, 630-632.
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Fannjiang Y*, Cheng W C*, Lee SJ, Qi B, Pevsner J, McCaffery JM, Hill RB, Basanez G, and Hardwick JM (2004). Mitochondrial fission proteins regulate programmed cell death in yeast. Genes & Dev. 18, 2785-2797. *co-f irst authors
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Morris MT, Cheng W C, Zhou XW, Brydges SD, and Carruthers VB (2004). Neospora caninum expresses an unusual single-domain Kazal protease inhibitor that is discharged into the parasitophorous vacuole. Int. J. Parasitol. 34, 693-701.