BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME Eric Strauch, M.D. eRA COMMONS USER NAME
POSITION TITLE Associate Professor, Surgery
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE YEAR(s INSTITUTION AND LOCATION (if FIELD OF STUDY ) applicable) The Johns Hopkins University, Baltimore, MD Georgetown University, Washington, DC U of Maryland School of Medicine, Baltimore, MD University of Maryland Hospital
BA
1980-83
Biology
MS MD
1983-4 1984-8
Physiology Medicine
Resident
1988-94
Surgery
The Johns Hopkins University School of Medicine and U of Maryland School of Medicine, Fellow 1994-96 Pediatric Surgery Baltimore, MD Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch. Employment 1996.2005Assistant Professor of Surgery, The University of Maryland School of Medicine, Baltimore, MD, Chairman-Bruce Jarrell, M.D., full-time position. 2005-present Associate Professor of Surgery, The University of Maryland School of Medicine, Baltimore, MD, Stephen Bartlett, M.D., full-time position. Honors 1987
Member, Alpha Omega Alpha Medical Honor Society, Honors Surgery Clerkship, Anatomy Professional Societies
1999 2003
American Academy of Surgery American Pediatric Surgical Association Publications Original research and theoretical treatises
1. Strauch ED, Fabian DF, Turner J, Lefor AT. The combined effect of adoptive immunotherapy and hyperthermia in the treatment of multiple pulmonary metastases in mice. Surg. Onc. 3(1): 4552, 1994 2. Nelms C, Alvarez C, Strauch E, Lally K, Bass B. Glycocholic and taurocholic acids stimulate esophageal mucosal repair. Surg Forum 48:156158, 1997. 3. Benson JE, Strauch ED. Retropsoas hernia as a cause of chronic abdominal pain: CT diagnosis. Pediatr Radiol 28:312314, 1998.
4. Toretsky JA, Zitomersky N, Eskenazi AE, Voigt RW, Strauch ED et al. Glypican3 Expression in Wilms Tumor and Hepatoblastoma. J.Pediatr. Hem/Onc., Nov; 23(8): 496499, 2001 5. Rao JN, Li Li, Golovina VA, Platoshyn O, Strauch ED et al. K+ Channels Regulate PolymaineDependent Intestinal Epithelial Cell Migration Through CA2+RHOA Signaling Pathway. Am. J. Physiol. Cell Physiol., 280: C993C1007, 2001 6. Strauch ED, Wang JY, Bass BL. Bile Salt Stimulates Intestinal Epithelial Cell Migration through TGFB after wounding. J. Surg, Research,97(1): 4953, 2001 7. Strauch ED, Voigt RW, Hill JL. Gangrenous Intestine in a Hernia Can Be Reduced. J. Pediatr. Surg, 37(6) 919920, 2001 8. Li Li, Liu L, Rao JN, Esmaili A, Strauch ED et al. JunD Stabilization Results in Inhibition of Normal Intestinal Epithelial Cell Growth Through P21 After Polyamine Depletion. Gastroenterology, 123: 764779, 2002 9. Strauch ED, Bass BL,Rao JN, Vann JA, Wang, JY. NFκB Regulates Intestinal Epithelial Cell and Bile Salt Induced Migration after Injury. Ann Surg, 237: 494501, 2003. 10. Xie XY, Strauch ED, Sun CCJ. Choledochal Cyst and Multilocular Cyst of Pancreas. J. Human Path., 34 (1) 99101, Jan 2003 11. Yamaguchi J, Toledo A, Bass GL, Celeste FA, Rao JN, Wang JY, Strauch ED. Taurodeoxycholate Increase Intestinal Epithelial Cell Proliferation through Cmyc Expression. Surgery 135 (2): 21521, Feb 2004. 12. Strauch ED, Yamaguchi J, Bass BL, Wang JY. Bile Salts Regulate Intestinal Epithelial Cell Migration by NFκB Induced Expression of TGFβ. J Am Coll Surg. 197 (6): 97484, Dec 2003. 13. Zou T, Rao JN, Guo X, Liu L, Zhang HM, Strauch ED, Bass BL, Wang JY: NFқBmediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion. Am J Physiol Cell Physiol, 286: 10091017, 2004. 14. Toledo A, Yamaguchi J, Wang JY, Bass BL, Turner DJ, Strauch ED: Taurodeoxycholate Stimulates Intestinal Cell Proliferation and Protects Against Apoptotic Cell Death through Activation of NFқB. Dig Dig Dis Sci, 49:16641671, 2004. 15. Zhang HM, Keledjian KM, Rao JN, Zou T, Liu L, Marasa BS, Wang SR, Ru L, Strauch ED, Wang JY.Induced focal adhesion kinase expression suppresses apoptosis by activating NFkappaB signaling in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 May;290(5):C131020. 16. Alaish SM, Strauch ED The use of Alloderm in the closure of a giant omphalocele. J Pediatr Surg. 2006 Mar;41(3):e379. 17. Jen HC, Graber J, Hill JL, Alaish SM, Voigt RW, Strauch ED: Surgical necrotizing enterocolitis and intraventricular hemorrhage in premature infants under 1000 grams. J Peds Surg, in press, 2006. 18. Turner DJ, Alaish SM, Zou T, Rao, JN, Wang JY, and Strauch ED. Bile salts induce resistance to apoptosis through NFκBmediated XIAP expression. Ann Surg 245(3): 41525, 2007. 19. Turner DJ, Martin PC, Rao JN, Greenspon J, Zou T, Bass BL, Wang JY, and Strauch ED. Substance P regulates migration in rat intestinal epithelial cells. Ann Surg Mar; 245(3): 40814, 2007. 20. Sphingosine1phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. Greenspon J, Li R, Xiao L, Rao JN, Marasa BS, Strauch ED, Wang JY, Turner DJ. Dig Dis Sci. 2009 Mar;54(3):499510.
21. Intraabdominal pulmonary sequestration presenting with elevated urinary normetanephrine levels. Alaish SM, Greenspon J, Strauch ED, Sun CC. J Pediatr Surg. 2009 Mar;44(3):e11.
Books, Pamphlets, etc.
1. Schmeling DJ, Strauch ED, Hoffman MA. Epidemiological and experimental observation of biliary atresia. In Hoffman MA (ed): Current Controversies in Biliary Atresia. RG Landes, Austin, TX, 1992
2. Strauch E, contributor, Surgery on Call, Gomella LG, Lefor AT (eds), Appleton & Lange, Stamford, CT, 1996
3. Strauch ED, Hill JL. Intestinal Atresia, in Ziegler et al (ed).Oper. Pediatr. Surg, Appleton & Lange, Stamford, CT, 2003
4. Hill JL, Strauch ED. Imperforate anus, in Norton and Eiseman (ed) Surgical Decision Making. 4th edition, Philadelphia PA: WB Saunders Co, 2000
5. Hill JL, Strauch ED. Imperforate anus, in Norton and Eiseman (ed) Surgical Decision Making 5th edition, Philadelphia PA: WB Saunders Co, 2004
Research Support (Projects Ongoing or Completed During the Last 3 Years) “The Role of Bile Acid During Epithelial Restitution” Principal Investigator: Eric D. Strauch, M.D. Source: University of Maryland Type and Period: Intramural Grant $15,000; July 1, 2000 to June 30, 2001 The project was to investigate the role bile salts have during intestinal epithelial restitution after injury. “Bile Salt Modulates Intestinal Restitution through the Activation of NF-Kappa B” Principal Investigator: Eric D. Strauch, M.D. Source: University of Maryland Type and Period: Intramural Grant $15,000; July 1, 2001 to June 30, 2002 The project was to investigate the mechanism by which bile salts enhance early rapid restitution By activating the NF-Kappa B signalling pathway. Principal Investigator 4/1/08-3/31/10 The Critical Role of Bile Salts: Gut Protection in Critical Illness R21 RDK075409A NIH/NIDDK Total Direct Costs Awarded ($275,000) Co-Principal Investigator Mucosal Repair in Gut Surgical Disorders R01 DK 061972 NIH/NIDDK Total Direct Costs Awarded (928,750)
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