Maria Nurminskaya, Ph.D. Assistant Professor, Department of Biochemistry and Molecular Biology University of Maryland School of Medicine
Contact Information Business Address:
Department of Biochemistry and Molecular Biology University of Maryland School of Medicine 108 N. Greene St. Baltimore, MD 21201
Business Phone Number: (410)706-8904 Fax: (410)706-8297 E-mail: mnurminskaya@som.umaryland.edu
Education Ph.D.
B.Sc. Biochemistry, (Magna Cum Laude), Moscow State University, Russia Molecular Biology, Moscow State University, Russia
Post Graduate Education and Training -
Postdoctoral Fellow, Anatomy and Cellular Biology (Mentors: Drs. Thomas Linsenmayer and David Birk), Tufts University, Boston, MA, USA Research Assistant Professor (non-tenure track) of Anatomy and Cellular Biology, Tufts University, Boston, MA, USA
Employment History 2009-present
Assistant Professor (tenure track) of Biochemistry and Molecular Biology University of Maryland School of Medicine, Baltimore, MD, USA
Affiliations 2010-present 2011-present
Associate Member, Joint Ph.D. Program in Biochemistry and Molecular Biology Graduate Program, University of Maryland, Baltimore and University of Maryland, Baltimore County affiliated member of the UMSOM Stem Cell Center
Professional Memberships 2006-present 2007-present 2010 -present 2010-present
North American Vascular Biology Organization (NAVBO) American Society for Matrix Biology (ASMB) Society for Biomaterials American Heart Association
Honors and Awards 1987-1992 1997 1999-2000 2001 2004 2006 2008 2009
Russian Academy of Sciences Graduate Fellowship Keystone symposium travel award Charles A. King Trust Fellowship Charlton Faculty Research Award Natalie V. Zucker Award European Science Foundation Fellowship Russo Foundation Award Paul Teschan Research Award (co-PI)
Manuscript reviewer Journal of Investigative Dermatology (2010) Journal of Biological Chemistry (2005-present)
M. Nurminskaya Neuroscience letters (2007-2008) Journal of Cell Biology (2004-2007) Developmental Dynamics (2006 – present) Matrix Biology (2008-2010) Bone (2009) Cell Research (2009) BMC Immunology (2010) PLosOne (2011-present)
Publications (* indicates corresponding authorships) Journals (Refereed) 1. Kulaev I.S., Solovieva N.I., KalebinaT.S., Rudenskaya G.N., Nurminskaya M. (1988) Characterization of the collagenolytic activity of subtilisin-like proteinases. Dokl.Akad.Nauk USSR, 302: 499-503 2. Nurminskaya M., KalebinaT.S., Kulaev I.S. Collagen-like sequences in fungal genomes. (1991) Genetika, 27:364366 3. Nurminskaya M., Kalebina T.S., Nurminsky D.I., Kulaev I.S. (1993) Analysis of Candida utilis genomic DNA homologous to cDNA of chicken A 1(1) collagen gene. Arch. Microbiol., 160: 329-331 4. Nurminskaya M., Kalebina T.S., Roitberg M.A., Kulaev I.S. (1994) Microorganismic genomic fragments homologous to cDNA of pro-Al(I) chicken collagen. Mikrobiologia ,63:86-89 5. Kalebina T.S., Nurminskaya M., Zang S., Chertov O. Y., Rudenskaya G.N., Stepanov V.M., Kulaev I.S. (1994) Various proteinases in structural investigation of Candida utilis cell wall. Bioorg.Chemistry, 20: 627-634 6. Birk D.E., Nurminskaya M., Zycband E.I. (1995) Collagen fibrillogenesis in situ: fibril segments undergo postdepositional modifications resulting in linear and lateral growth during matrix development. Devel. Dynam., 202:229-243 7. Rudenskaya G.N., Isaev V.A., Stepanov V.M., Dunaevsky Ya.E., BaratovaL.A., KalebinaT.S., Nurminskaya M. (1996) Isolation and properties of serine proteinase PC of kamchatka crab Paralithodes camtschatica - a proteolytic enzyme of broad specificity. Biochemistry (Mosc), 6: 1119-1132 8. Nurminskaya M., Linsenmayer T.F.. (1996) Identification and characterization of up-regulated genes during chondrocyte hypertrophy. Devel. Dynam., 206: 260-271 9. Nurminskaya M., Birk D.E. (1996) Differential expression of fibromodulin mRNA associated with tendon fibril growth: isolation and characterization of chicken fibromodulin cDNA. Biochem.J, 317: 785-789 10. Nurminskaya M., Linsenmayer T.F. (1996) Analysis of up-regulated genes during chondrocyte hypertrophy. Ann.NY Acad.Sci, 785:309-310. 11. Nurminskaya M., Magee C., Nurminsky D., Linsenmayer T.F. (1998) Plasma transglutaminase in hypertrophic chondrocytes: expression and cell-specific intracellular activation produce cell death and externalization. J.Cell Biol, 142:1135-1144. 12. Nurminsky D.I., Nurminskaya M., De Aguiar D., Hartl D.L. (1998) Selective sweep of a newly evolved spermspecific gene in Drosophila. Nature, 396:572-575 13. Nurminskaya M.V., Birk D.E. (1998) Differential expression of genes associated with collagen fibril growth in the chicken tendon: identification of structural and regulatory genes by subtractive hybridization. Arch. Biochem. Biophys., 350: 1-9 14. Nurminsky D.I., Nurminskaya M., Benevolenskaya E.V., Shevelyov Y.Y., Hartl D.L., Gvozdev V.A. (1998) Cytoplasmic dynein intermediate chain isoforms with different targeting properties created by tissue specific alternative splicing. Mol.Cell.Biol, 18: 6816-6825. 15. Magee C., Nurminskaya M., Linsenmayer T.F. (2001) Role of UDP-glucose pyrophosphorylase in hyaluronan synthesis in the growth plate. Biochem J, 360: 667-674 16. Nurminskaya M.V., Linsenmayer T.F. (2002) Immunohistological analysis of transglutaminase factor XIIIA expression in mouse embryonic growth plate. J.Orth.Res. 20: 181-184 17. Nurminskaya M., Linsenmayer T.F. (2002) Transglutaminase promotes osteoblast maturation of periosteal cells of the developing long bone. Minerva Biotech., 14: 220. 2
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18. Nurminskaya M, Magee C., Faverman L. and T. F. Linsenmayer (2003) Chondrocyte-derived transglutaminase promotes maturation of preosteoblasts in periosteal bone Dev.Biol, 263: 139-152 19. Magee C, Nurminskaya M, Faverman L. and T. F. Linsenmayer (2005) SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes (co-first authors) J. Biol. Chem. 280:2533125338 20. Nurminskaya M*, Kaartinen MT. (2006) Transglutaminases in mineralized tissues. Front. Biosci. 11:1591-1606. 21. Nurminsky D, Magee C, Faverman L, Nurminskaya M.* (2007) Regulation of chondrocyte differentiation by actinsevering protein adseverin. Dev. Biol. 302:427-437. 22. Mikhaylova, L., Malmquist J., Nurminskaya M.* (2007) Regulation of in vitro vascular calcification by chondrocytesecreted factors. Calcif. Tissue Int. 81:372-381. 23. Faverman L., Mikhaylova L., Malmquist J., Nurminskaya M.* (2008) Extracellular transglutaminase 2 activates beta-Catenin signaling in calcifying vascular smooth muscle cells. FEBS Letters 582:1552-1557. 24. Beazley K.E., Nurminskaya M., Talbot C.J., Linsenmayer T.F. (2008) Corneal epithelial nuclear ferritin: developmental regulation of ferritin and its nuclear transporter ferritoid. Dev. Dynam. 237:2529-2541. 25. Ilyinskii P., Nurminskaya M, Gabai V., Altstein A., Prilipov A., Thoidis G., Shneider A. (2009) Effective expression of recombinant cytotoxic protein via its attachment to a polyglutamine domain. OMICS, 13(3):211-7. 26. Nurminskaya M, Talbot CJ, Nurminsky D, Beazley KE, Linsenmayer TF. (2009) Nuclear ferritin: a ferritoid-ferritin complex in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2009 50(8):3655-61. 27. Beazley K.E., Nurminskaya M., Talbot C.J., Linsenmayer T.F. (2009) Phosphorylation regulates the ferritoidferritin interaction and nuclear transport. J Cell Biochem, 107(3):528-36. 28. Nurminsky D., Shanmugasundaram S., Michaud C., Deasey S., Hendig D., Dastjerdi A., Balczerski B., FrancisWest P. and Nurminskaya M.* (2011) Transglutaminase 2 regulates early chondrogenesis and glycosaminoglycan synthesis. Mech Dev, 128(3-4):234-45
29. Deasey S and Nurminskaya M* (2011) Tissue-specific response to the loss of Transglutaminase 2, Amino Acids, DOI: 10.1007/s00726-011-1183-9, in press 30. Deasey S., Du S., Grichenko O, Nurminskaya M* (2012) Regulation of bone mineralization by Transglutaminasemediated cross-linking in Zebrafish. Amino Acids, 42(2-3):1065-75 31. Shanmugasundaram S., Logan- Mauney S., Burgos K., Nurminskaya M* (2012) Tissue transglutaminase regulates chondrogenesis in mesenchymal stem cells on collagen type XI matrices. Amino Acids, 2(2-3):1045-53. 32. Beazley K.E, Deasey S, Lima F., Nurminskaya M* (2012) Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification. ATVB, 32(1):123-30. 33. Lin X, Shanmugasundaram S, Liu Y, Derrien A, Nurminskaya M, Zamora PO. (2012) B2A peptide induces chondrogenic differentiation in vitro and enhances cartilage repair in rats. J Orthop Res. Jan 23. doi: 10.1002/jor.22078. [Epub ahead of print] 34. Beazley,K.; Zhang, T.; Lima, F; Pozharskaya, T; Niger, C.; Tzitzikov, E.;Azimzadeh,A.; Nurminskaya M. * (2012) Implication for transglutaminase 2-mediated activation of b-catenin signaling in neointimal vascular smooth muscle cells in chronic cardiac allograft rejection, J Heart and Lung Tranpl, in press Book Chapters 35. Linsenmayer T.F., Long F., Nurminskaya M. V., Chen Q., Schmid T. M. (1998) Type X collagen and other upregulated components of the avian hypertrophic cartilage program. in “Progress in Nucleic Acid Research and Molecular Biology”, Academic Press, pp 79-111 36. Linsenmayer T.F., Nurminskaya M.V. (1998) Cartilage hypertrophy: isolation and characterization of upregulated genes in “Extracellular matrix-cell interaction - molecules to disease”, Japan Sci.Soc.Press, pp.111-121. 37. Nurminskaya M. and Belkin A. (2012) New insights into the roles of transglutaminases in cell biology”, International Review of Cell & Molecular Biology, 294:1-97. Abstracts and/or Proceedings 1. Nurminskaya, M*, Malmquist, J. (2006). Regulation of transglutaminase-induced calcification in VSM cells by the LRP/beta-catenin. Vascular Pharmacology 45, e109. 3
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2. Nurminskaya, M. (2006). Transglutaminase 2 promotes VSMC calcification through LRP/beta-catenin signaling. FASEB J. 20, A636.
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