D’Souza, W. D.
CURRICULUM VITAE Warren D. D’Souza, PhD, MBA Associate Professor, Department of Radiation Oncology University of Maryland School of Medicine, Baltimore, MD DATE
October 15, 2013
CONTACT INFORMATION Business Address:
Business Phone Number: Fax Number: Email: Citizenship: Foreign Languages:
Department of Radiation Oncology University of Maryland Medical Center 22 South Greene St. Baltimore, MD 21201 410-328-2323 410-328-2618 wdsou001@umaryland.edu USA Hindi (working knowledge), Konkani (fluent)
EDUCATION B.S. (Summa Cum Laude)
Xavier University, Cincinnati, OH College of Arts and Sciences, 1995 Major: Applied Physics Minor: Mathematics
M.S.
University of Wisconsin, Madison, WI Department of Medical Physics, School of Medicine, 1998 Major: Medical Physics
Ph.D.
University of Wisconsin, Madison, WI Department of Medical Physics, School of Medicine, 2000 Thesis: A sequential mixed-integer optimization framework for permanent brachytherapy implants Thesis Advisors: Bruce R. Thomadsen and Robert R. Meyer
M.B.A (Fuqua Scholar)
Duke University, Durham, NC The Fuqua School of Business, 2013 Concentration in Health Sector Management Graduated Top 10% of Class
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D’Souza, W. D.
CERTFICATIONS American Board of Radiology (ABR) – Therapeutic Radiologic Physics, 2003
EMPLOYMENT HISTORY ACADEMIC APPOINTMENTS 06/1994 – 08/1994
Research Assistant, Research Experience for Undergraduates (REU) Program, Michigan State University, East Lansing, MI. (Feasibility study of boron neutron capture therapy (BNCT) using K100 superconducting cyclotron at Harper Hospital, Detroit
06/1995 – 06/2000
Research Assistant, Department of Medical Physics, University of Wisconsin, Madison, WI
07/2000 – 02/2002
Instructor, Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, TX
03/2002 – 12/2007
Assistant Professor, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
02/2008 – 05/2008
Associate Professor and Director of Medical Physics, Department of Radiation Medicine, Oregon Health and Science University, Portland, OR
05/2008 - present
Associate Professor and Chief of Medical Physics, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
10/2008 – present
Associate Professor (Affiliate), Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, MD
PROFESSIONAL SOCIETY MEMBERSHIPS 1998 – present 2002 – present 2008 - present 2008 – present 2008 – present
Member, American Association of Physicists in Medicine (AAPM) Member, Mid-Atlantic Chapter of American Associate of Physicists in Medicine (MAC-AAPM) Member, The Society of Nuclear Medicine (SNM) Member, American Society for Therapeutic Radiology and Oncology (ASTRO) Member, Particle Therapy Cooperative Group (PTCOG)
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HONORS AND AWARDS 1991 – 1995 1993 1994 1999 1999 – 2000 2004 2005 2006 2013
2013
University Presidential Scholarship, Xavier University, Cincinnati, OH Inducted into Sigma Pi Sigma, National Undergraduate Physics Honor Society Inducted into Phi Mu Epsilon, National Undergraduate Math Honor Society Student Presentation, 1st place, AAPM (North Central Chapter) Meeting Cremer Graduate Fellowship, University of Wisconsin School of Medicine, Madison, WI Marquis Who’s Who in Medicine and Healthcare AAPM Medical Physics Travel Grant Marquis Who’s Who of Emerging Leaders Health Sector Management Scholar Award (Graduated Top of the Class in Health Sector Management Curriculum): Duke University – The Fuqua School of Business Fuqua Scholar (Graduated Top 10% of Class), Duke University – The Fuqua School of Business, Durham, NC
CLINICAL ACTIVITIES 2000 – 2002
Co-led introduction of intensity-modulated radiation therapy (IMRT) for gynecologic oncology patients. Impact: One of only three academic sites nationally to perform IMRT in this clinical indication at the time. This treatment is now adopted as the standard-of-care.
2002
Led clinical implementation of ultrasound-based image-guided radiation therapy (IGRT) for prostate. Impact: First clinical program to offer ultrasound-based IGRT technology to patients in the Mid-Atlantic region.
2002 – 2005
Primary medical physicist performing ultrasound-guided I-125 and Cs-131 prostate seed implant and high dose-rate (HDR) brachytherapy for gynecology and breast cancer with radiation oncologist. Impact: First clinical program to initiate prostate seed radiation therapy with Cs-131 to intermediate and high-risk prostate cancer patients in the Northeast and the Mid-Atlantic regions.
2002 – 2008
Performed routine machine calibration and quality assurance, treatment planning and patient-specific treatment quality assurance as part of clinical medical physics team at University of Maryland. Impact: Supported ongoing therapeutic safety and precision.
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2003
Collaborated with clinical team to commission and introduce the Pinnacle3 planning system for routine intensity modulated radiation therapy (IMRT) treatment planning. Impact: Over 50% of patients treated with radiation therapy at University of Maryland receive IMRT, which results in the minimization of organ-atrisk and normal tissue exposure to high doses.
2004
Led clinical adoption of breath-hold techniques for breast cancer treatment to improve treatment setup reproducibility and decrease cardiac toxicity. Impact: Breast and lung patients treated with radiation therapy received less dose to the heart and lung tissues.
2005
Led clinical implementation of stereotactic body radiation therapy (SBRT) program, which improved patient convenience by reducing number of treatments while maintaining outcomes. Impact: Over 200 patients have been successfully treated in the last five years.
2006 – 2009
Member of clinical team and primary medical physicist for Gamma Knife Radiosurgery program. Impact: Ongoing support for clinical program, which treated > 200 patients during this time-frame.
2007
Led clinical implementation team for advanced image-guided therapy techniques such (e.g. 4D CT imaging and tumor motion management using “gated” radiation therapy). Impact: Advanced motion management therapy techniques are standardof-care for thoracic and abdominal tumors. 200+ patients have now been treated using advanced motion management techniques.
2008 – present
Provide administrative oversight of a clinical division that comprises 19 faculty, 19 staff and 12 trainees.
2008 - present
Provide direct oversight of radiation oncology medical physics program (daily census of 200 patients) at the academic medical center and three community practice affiliates.
2008 - present
Develop annual capital budget requests involving state-of-the-art radiation therapy equipment with hospital partners within UMMS. Impact: Negotiated approximately > $12 million in savings on capital equipment through collaborative partnerships with medical device vendors.
2008
Collaborated with executive team as technical lead to develop request for proposals for new for radiation oncology imaging, planning and delivery
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technologies at the University of Maryland Radiation Oncology Medical Pavilion at Howard County site (a joint venture with Johns Hopkins). Impact: Facilitated the acquisition and deployment of clinical technology to support clinical program at a community practice. 2012 - 2013
Led strategy, business plan development and implementation of strategy with UMMS Chief Information Officer’s office and Oncology service line leadership to centralize and integrate the Department of Radiation Oncology’s information technology and clinical applications system infrastructure. Impact: Will create a centralized information systems infrastructure that will enable greater clinical integration, implementation of clinical practice guidelines and lead to $2.5 million in savings to UMMS over 5 years.
2012 - present
Chair the steering committee to determine acquisition of new technology, clinical practice guidelines using acquired technology and participated in the development of clinical treatment guidelines across multiple clinical sites. Impact: Provide guidance on the acquisition and adoption of new technology.
ADMINISTRATIVE SERVICE INSTITUTIONAL SERVICE 2006 - present
Co-Director, Program of Excellence for Translational Technology Research, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
2008
Co-Director, Program of Emerging Technologies in Radiation Therapy, Oregon Health and Science University, Portland, OR
2008 - present
Chief of Medical Physics Division, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
2008 - present
Member of Radiation Safety Committee, University of Maryland, Baltimore, MD
2008 - present
Member of Human Use Sub-Committee, University of Maryland, Baltimore, MD
2008 - present
Radiation Safety Officer, Gamma Knife Stereotactic Radiosurgery Center, University of Maryland Medical Center, Baltimore, MD
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D’Souza, W. D.
2008 – present
Radiation Safety Officer, High Dose Rate Brachytherapy Program, University of Maryland Medical Center, Baltimore, MD
2008 - present
Member of Executive Leadership Committee, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
2008 - present
Member of Department of Radiation Oncology Appointment, Promotion, Tenure (APT) Committee, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
2008 - present
Member of Executive Research Council, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
2008 - present
Member of Technology Research Review Committee, University of Maryland School of Medicine, Baltimore, MD
2008
Director, Radiation Linear Accelerator Shared Service (RLASS), University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD
2008 - present
Member of Summer Research Scholarship Award Committee, Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD
2008 - present
Member of Resident Selection Committee, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
2010 - present
Radiation Safety Officer, GammaPod, University of Maryland Medical Center, Baltimore, MD
2010 - present
Member of Advisory Committee, Medical Dosimetry Program, University of Maryland Medical Center, Baltimore, MD
2011 - present
Member of Information Techonology Steering Committee, Department of Radiation Oncology, University of Maryland Medical System, Baltimore, MD
2012 - present
Director of Information Technology and Information Systems, Department of Radiation Oncology, University of Maryland Medical System, Baltimore, MD
2013 - present
Chair, Technology Steering Committee, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
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D’Souza, W. D.
2013
Member of Executive Steering Committee, Upper Chesapeake Medical Center Radiation Oncology, University of Maryland Medical System, Bel Air, MD
2013
Member of Referring Physician Steering Committee, University of Maryland Medical Center, Baltimore, MD
2013 – present
Member of Clinical Resource Advisory Group Committee, University of Maryland School of Medicine, Baltimore, MD
LOCAL SERVICE 2004 – 2006
Editor, Mid-Atlantic Chapter Newsletter, American Association of Physicists in Medicine
NATIONAL SERVICE 2000 – present
Reviewer, International Journal of Radiation Oncology Biology Physics (~ 2 per year) Reviewer, Medical Physics (~ 2 per year) Reviewer, Physics in Medicine and Biology (~ 1 per year) Reviewer, Radiotherapy and Oncology (~ 1 per year) Reviewer, Journal of Applied Clinical Medical Physics (~ 1 per year)
2004
Session Chair, American Society of Therapeutic Radiation Oncology (ASTRO) National Meeting
2006
Faculty Mentor, Summer Undergraduate Fellowship Program, American Association of Physicists in Medicine
2006 – present
Abstract Reviewer, Annual National Meeting American Association of Physicists in Medicine (AAPM)
2007 – present
Member of [JWGRSF] Joint Working Group for Research Seed Funding Initiative Committee, American Association of Physicists in Medicine
2007 – 2011
Member of [WGCT] Work Group on Clinical Trials Committee, American Association of Physicists in Medicine
2007
Member of Organizing Committee, Real-time Motion Adaptive Radiation Therapy Workshop, Georgetown University, May 11-12, 2007
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D’Souza, W. D.
2007 – 2009
Scientific Session Chair, American Association of Physicists in Medicine National Meeting
2008
Member of Physical Imaging/Radiation Oncology (PIM/RON-2) Grant Peer Review Panel - Prostate Cancer Research Program (PCRP), Congressionally Directed Medical Research Programs (CDMRP), Department of Defense (DOD)
2009
Member of Program Committee, Special Session: Machine Learning Methods for Modeling Treatment Outcomes in Cancer and Radiation Therapy. The 8th International Conference on Machine Learning and Applications (ICMLA 2009), Miami, FL.
2009 – 2010
Member of Medical Imaging (MEDI) Study Session (October 2009, February 2010), Center for Scientific Review, National Institutes of Health
2011 – present
Associate Editor, Medical Physics, International Journal of Radiation Oncology Biology Physics
2010
Scientific Session Moderator, Annual American Association of Physicists in Medicine Meeting
2011
Member of 53rd ASTRO Annual Meeting (Miami, FL) Program Assembly Committee
2012
Scientific Session Moderator, Annual American Association of Physicists in Medicine Meeting
2012 – present
Member of Investment Committee, American Association of Physicists in Medicine
2013
Member of Special Emphasis Panel ZRG1 SBIB-Z (57) Study Session (June, 2013), Center for Scientific Review, National Institutes of Health.
2013
Scientific Session Moderator, Annual American Association of Physicists in Medicine National Meeting
TEACHING ACTIVITIES 1997-1999
Teaching Assistant, Department of Medical Physics, University of Wisconsin, Madison, WI External beam physics laboratory, 10-12 students, 3 hours per semester
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D’Souza, W. D.
2000 – 2002
Instructor, Interstitial and Intracavitary dosimetry: Basic methods and calculations, University of Texas M.D. Anderson Cancer Center, Houston, TX Nationally recognized didactic course offered to radiation oncologists, medical physicists and dosimetrists, approximately 40 participants, 5 hours per year
2001
Instructor, Medical Physics Survey Course to Undergraduate Students, University of Houston, Houston, TX 15-25 students, 3 hours per semester
2002 – 2007
Instructor, Radiation Oncology Residency program, University of Maryland Medical Center, Baltimore, MD 7-10 students, 8 lecture hours per year
2002 - 2007
Instructor, Medical Dosimetry Program, University of Maryland Medical Center, Baltimore, MD, 2 students, 8 lecture hours per year
2004 - 2009
Faculty/Instructor, Annual Radiobiology/Physics Review Course for Radiation Oncology Residents, University of Maryland School of Medicine 50-65 students, 1 lecture hour per year
2008 – 2009
Instructor, Radiation Oncology Residency program, University of Maryland Medical Center, Baltimore, MD 7-10 students, 6 lecture hours per year
2008 - 2009
Instructor, Medical Dosimetry Program, University of Maryland Medical Center, Baltimore, MD 2 students, 6 lecture hours per year
2008 - present
Course Coordinator, Medical Physics Lectures, Radiation Oncology Residency program, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 9-12 students, Syllabus development, Faculty coordination, Development of exams and grading of 3 exams per year, 40 lectures per year
2009 - present
Course Director, National Radiobiology and Physics Review Course for Radiation Oncology Residents, University of Maryland School of Medicine, Baltimore, MD This review course is nationally recognized and has experienced progressively increased attendance with 94 registrants in 2013.
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D’Souza, W. D.
2008 - 2010
Faculty Advisor, Medical Physics orientation for first-year Radiation Oncology residents, Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD 2-3 residents, 4 lecture hours per year
2010 - present
Instructor, Radiation Oncology Residency program, University of Maryland Medical Center, Baltimore, MD 7-10 students, 4 lecture hours per year
2010 - present
Instructor, Medical Dosimetry program, University of Maryland Medical Center, Baltimore, MD 2 students, 4 lecture hours per year
GRADUATE STUDENTS, POST-DOCTORAL FELLOWS, MEDICAL RESIDENTS AND MEDICAL STUDENTS MENTORING: Medical Student Mentoring 2009
Student: Sarah Sassor Resident, Division of Plastic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN Role: Served as summer mentor for 1st year medical student, who was awarded Department of Radiation Oncology summer research assistantship
2011-2012
Student: Tejan Diwanji Internship, Union Memorial Hospital, Baltimore, MD Role: Served as mentor for 3rd year medical student, who spent a year doing full-time research in our laboratory
Resident and Fellow Mentoring 2000-2002
Resident: Hoon K. Lee Radiation Oncologist, Regional Radiology, 360 Bard Avenue, Staten Island, NY 10310 Role: Served as research project mentor during radiation oncology residency
2000-2002
Resident: Anesa Ahmad Radiation Oncologist, 21st Century Oncology, 3426 North Roosevelt Boulevard, Key West, FL 33040 Role: Served as research project mentor during radiation oncology residency
2002-2004
Resident: Chad Deyoung
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Radiation Oncologist, Cornwall Radiation Oncology, 15 Laurel Avenue, Suite 100, Cornwall, NY 12518 Role: Served as research project mentor during radiation oncology residency 2002-2006
Resident: Shilpen Patel Assistant Professor, Department of Radiation Oncology, University of Washington School of Medicine, Seattle, 1959 NE Pacific Street, Box 356043, Seattle, WA 98195 Role: Served as research project mentor during radiation oncology residency
2003-2007
Resident: Anil Dhople Radiation Oncologist, MIMA Cancer Center, 1130 S. Hickory Street, Melbourne, FL 32901 Role: Served as research project mentor during radiation oncology residency
2005-2009
Resident: Alireza Mirmiran Radiation Oncologist, Methodist Estabrook Cancer Center, 8303 Dodge Street, Omaha, NE Role: Served as research project mentor during radiation oncology residency
2006-2010
Resident: Matthew Koshy Assistant Professor, Department of Radiation Oncology, University of Chicago Duchossois Center For Advanced Medicine, 5758 Maryland Avenue, 9006, Chicago, IL 60637 Role: Served as research project mentor during radiation oncology residency
2007-2011
Resident: Geoffrey Neuner Radiation Oncologist, Greater Baltimore Medical Center, 6701 North Charles Street, Baltimore, MD 21204 Role: Served as research elective mentor during 6-month elective in radiation oncology residency
2010-2014
Resident: Adam Reece Resident (PG Y5), Department of Radiation Oncology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201 Role: Served as research elective mentor during 6-month elective in radiation oncology residency
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Graduate Student Mentoring 2003-2005
Student: Hao H. Zhang Instructor, Department of Radiation Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD Role: Served as a secondary advisor during PhD dissertation research through a collaboration with the Department of Industrial & Systems Engineering, University of Wisconsin, Madison, WI
2004-2005
Student: Kelly Peterson Product Development, Philips Medical Systems Role: Served as a faculty mentor for research project during her graduate assistantship in the Department of Computer Sciences at the University of Wisconsin, Madison, WI
2008-2012
Student: Kathleen T. Malinowski Clinical Collaborations Manager, Varian Medical Systems, Seattle, WA Role: Served as PhD thesis advisor and mentor in the Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park
2009-present
Student: Yuan-Chia (Charles) Kuo Graduate Student, Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742 Role: Serve as primary PhD thesis advisor and mentor in the Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park
Post-Doctoral Fellow Mentoring 2004-2006
Student: Daryl P. Nazareth Assistant Professor, Department of Radiation Oncology, Roswell Park Cancer Institute, Buffalo, NY Role: Served as advisor and supervisor during post-doctoral research fellowship
2005-2007
Student: Seth Van Liew Assistant Professor, Department of Radiation Oncology, Boston University Medical Center, Boston, MA Role: Served as advisor and supervisor during post-doctoral research fellowship
2005-2008
Student: Jianzhou Wu
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D’Souza, W. D.
Medical Physicist, Department of Radiation Oncology, Swedish Cancer Institute, Seattle, WA Role: Served as advisor and supervisor during post-doctoral research fellowship
2008-2010
Student: Hao H. Zhang Instructor, Department of Radiation Oncology, University of Maryland, Baltimore, MD Role: Served as advisor and supervisor during post-doctoral research fellowship
2008-2009
Student: Zhengdong Wang Assistant Professor, Department of Radiation Oncology, University of Miami, Miami, FL Role: Served as advisor and supervisor during post-doctoral research fellowship
2008-2010
Student: M. Ali Yousuf Biomedical Engineer and Instructor Johns Hopkins Medicine and Center for Talented Youth, Baltimore, MD Role: Served as advisor and supervisor during post-doctoral research fellowship
2010-2011
Student: Dhaval Shah Product Development Engineer, Intel, Beaverton OR Role: Served as advisor and supervisor during post-doctoral research fellowship
2009-2011
Student: Jidong Hou Scientist, Electrical Geodesics, Inc. Eugene, OR Role: Served as advisor and supervisor during post-doctoral research fellowship
2012-present
Student: Karen Mooney Post-doctoral Fellow, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD Role: Serve as advisor and supervisor during post-doctoral research fellowship
2012-present
Student: Hamid Ghaffari Post-doctoral Fellow, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD Role: Serve as advisor and supervisor during post-doctoral research fellowship
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D’Souza, W. D.
2013-present
Student: Daliborka Stajonevic Research Data Analyst, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD Role: Serve as supervisor
GRANT SUPPORT ACTIVE 07/01/13-04/30/17
(Co-Investigator, 4%) Principal Investigator: W. Lu “Quantitative PET/CT Analysis to Improve Evaluation of Tumor Response” NIH R01 CA172638 Annual Direct Costs: $207,500 Total Direct Costs: $830,000 Total Overall Costs: $1,274,052
10/01/07-07/30/14
(Principal Investigator, 14%) “Feedback Control of Respiration Induced Tumor Motion with a Treatment Couch” NIH R01 CA124766 Annual Direct Costs: $217,913 Total Direct Costs: $1,082,084 Total Overall Costs: $1,399,408
04/01/13-03/31/14
(Principal Investigator, No salary support) “Contrast Enhanced 4D CT in Abdominal Imaging” Philips Medical Systems, Cleveland, OH Annual Direct Costs: $30,000 Total Direct Costs: $30,000 Total Overall Costs: $42,000
07/01/09-05/30/14
(Principal Investigator, 15%) “High-Throughput Computing for a Distributed Multi-Plan Radiotherapy Computing Framework” NIH R01 CA130814 Annual Direct Costs: $237,861 Total Direct Costs: $943,157 Total Overall Costs: $1,218,973
07/01/12-06/30/15
(Principal Investigator, 5%) “Master Research Agreement” Varian Medical Systems, Palo, Alto Annual Direct Costs: $187,500 Total Direct Costs: $562,500
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D’Souza, W. D.
Total Overall Costs:
$750,000
COMPLETED GRANTS: 11/01/04-10/30/06
(Principal Investigator, 8%) “Collaborative Research: Interdisciplinary Center for Radiation Treatment Planning” NSF DMI-0355567 Annual Direct Costs: $120,000 Total Direct Costs: $240,000 Total Overall Costs: $356,402
07/01/05-06/30/08
(Principal Investigator, 5%) “Development of intra-fraction motion-synchronized couch” 3Dline Medical Systems, Reston, VA Annual Direct Costs: $50,000 Total Direct Costs: $150,000 Total Overall Costs: $180,000
10/01/06-09/30/09
(Principal Investigator, 6.5%) “Feedback Control and Inferential Modeling for a Radiotherapy Treatment Couch” NIH R21 CA122403 Annual Direct Costs: $143,783 Total Direct Costs: $211,115 Total Overall Costs: $287,220
07/01/05-06/30/11
(Principal Investigator, 3%) “Master Research Agreement” Varian Medical Systems, Palo, Alto Annual Direct Costs: $187,500 Total Direct Costs: $937,500 Total Overall Costs: $1,250,000
07/01/07-06/30/11
(Co-Investigator, 7.5%) Principal Investigator: C. X. Yu “Four-dimensional IMAT planning using graph algorithms” NIH R01 CA 117997 Annual Direct Costs: $249,358 Total Direct Costs: $1,003,893 Total Overall Costs: $1,217,156 15
D’Souza, W. D.
10/01/11-09/30/12
(Principal Investigator, No salary support) “Investigation of 4D CT for Lung and Abdominal Imaging” Philips Medical Systems, Cleveland, OH Annual Direct Costs: $30,000 Total Direct Costs: $12,000 Total Overall Costs: $42,000
CLINICAL TRIALS 2007
(GCC #0546) Principal Investigator: 4D CT Imaging, Tissue Segmentation, and Correlation of Breathing Signals and Tumor Motion
2007
(GCC #0631) Principal Investigator: Investigating Patient’s Experiences On a Moving Table
2008
(GCC #0832) Principal Investigator: Investigating the improvement in 4D CT images using Audiovisual BioFeedBack: An intra-fraction and an inter-fraction evaluation
2009
(GCC #0943) Principal Investigator: Dynamic MRI for Lung Tumor Motion and Lung Function
2010
(GCC 1008) Co-Investigator (PI: Gullapalli): Neuroimaging Correlates in Evaluating Cognitive Function Following Radiation Therapy
2010
(GCC #1009) Co-Investigator (PI: Guerrero): Retrospective review of patient imaging to assess treatment response in locally advanced head and neck cancer
2010
(GCC #1044) Co-Investigator (PI: Amin): Evaluating Treatment Outcomes and Toxicities of Prostate Cancer Patients Treated with Brachytherapy
2011
(RTOG 08-39) Co-Investigator & National Medical Physics Chair (PI: Edelman): Randomized Phase II Study of Pre-Operative Chemoradiotherapy +/Panitumumab (IND #110152) Followed By Consolidation Chemotherapy In Potentially Operable Locally Advanced (Stage IIIA, N2+) Non-Small Cell Lung Cancer.
2012
(GCC 1043) Principal Investigator: Magnetic Resonance Imaging for Evaluating Tumor and Node Response and Normal Tissue Function to Concurrent Chemotherapy and Radiation Therapy in Head and Neck Cancer
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PATENTS (ISSUED AND PUBLISHED): 1. E. L. Madsen, W. D. D’Souza, G. R. Frank. Multi-Imaging Modality Tissue Mimicking Materials for Imaging Phantoms. U.S. Patent US6318146, Filed: 07/14/1999, Issued: 11/20/2001. 2. E. L. Madsen, W. D. D’Souza, G. R. Frank. Multi-Imaging Modality Tissue Mimicking Materials for Imaging Phantoms. U.S. Patent US6635486, Filed: 07/27/2001, Issued: 10/21/2003 3.
B. R. Thomadsen, W. D. D’Souza, M. Meltsner. Device for placement of needles and radioactive seeds in radiotherapy. U.S. Patent US 7578781, Filed: 09/17/2004, Issue: 08/25/2009.
4.
R. R. Meyer, L. Shi, W. D. D’Souza. Automated software system for beam angle selection in teletherapy. U.S. Patent US7876882, Filed: 02/04/2008, Issued: 01/25/2011.
5.
W. D. D’Souza, X. C. Yu, M. Suntharalingam, W. F. Regine, T. J. McAvoy. Techniques for compensating movement of a treatment target in a patient. U.S. Patent US8042209, Filed: 04/12/2006, Issued: 10/25/2011.
6.
W. D. D’Souza, X. C. Yu, M. Suntharalingam, W. F. Regine, T. J. McAvoy. Techniques for compensating movement of a treatment target in a patient. EPO Application EP1874388, Filed: 04/12/2006, Published: 01/09/2008
7.
W. D. D’Souza, H. H. Zhang, K. Malinowski. Techniques for compensating movement of a treatment target in a patient. US 2012/0004518 A1, Filed: 06/29/2011, Published: 01/05/2012.
8.
W. D. D’Souza, K. Malinowski, T. J. McAvoy. Method for Monitoring the Accuracy of Tissue Motion Prediction from Surrogates. US 2013/0018232 A1, Filed: 06/22/2012, Published: 01/17/2013.
PROVISIONAL PATENT APPLICATIONS (SUBMITTED) 1. N. Mistry, W. D. D’Souza, T. Diwanji, S. Feigenberg. Quantitative Evaluation of Fractional Regional Ventilation Using Four-Dimensional Computed Tomography. US Provisional Patent Application Number: 61/646,554 2.
M. Xue, W. Lu, H. H. Zhang, S. Kligerman, W. D’Souza. Methods and systems for individually optimizing uniform contrast enhancements in computed tomography imaging. US Provisional Patent Application Number: 61/828,383.
3.
H. H. Zhang, W. D. D’Souza and N. N. Mistry. Functional imaging based radiotherapy with motion management. US Provisional Patent Application Number: 61/861,036.
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W. D. D’Souza, R. R. Meyer, B. R. Thomadsen, M. C. Ferris, “An iterative sequential mixed-integer approach to automated prostate brachytherapy treatment plan optimization”, Phys. Med. Biol. 46, 297-322, 2001. W. D. D’Souza, E. L. Madsen, O. Unal, K. K. Vigen, G. R. Frank, and B. R. Thomadsen, “Tissue mimicking materials for a multi-imaging modality prostate phantom”, Med. Phys. 28, 688-700, 2001. W. D. D’Souza and R. R. Meyer, “Dose homogeneity as a function of source activity in optimized I-125 prostate implant treatment plans”, Int. J. Radiat. Oncol. Biol. Phys. 51, 1120-1130, 2001. W. D. D’Souza and H. D. Thames, “Is the / ratio for prostate cancer low?”, Int. J. Radiat. Oncol. Biol. Phys. 51, 1-3, 2001. R. R. Meyer, W. D. D’Souza, M. C. Ferris, and B. R. Thomadsen, “MIP models and BB strategies in brachytherapy treatment optimization”, J. Global Optimization. 25, 23-42, 2003. W. D. D’Souza, H. K. Lee, M. B. Palmer, L. G. Smith and A Pollack, “Is intraoperative nomogram-based overplanning for prostate implants necessary?”, Int. J. Radiat. Oncol. Biol. Phys. 56, 462-467, 2003. H. D. Thames, W. D. D’Souza and D. A. Kuban, “Dual radiobiological interpretations of retrospective clinical data: the time factor”, Int J Radiat Biol 79, 503-509, 2003. W. D. D’Souza and I. I Rosen, “Non-tumor integral dose variation in conventional radiotherapy treatment planning”, Med. Phys. 30, 2065-2071, 2003. H. K. Lee, W. D. D’Souza, J. J. Yamal, A. Pollack and D. A. Kuban, “Dosimetric consequences of using a surrogate urethra to estimate urethral dose after brachytherapy for prostate cancer”, Int. J. Radiat. Oncol. Biol. Phys. 57, 355-361, 2003. J. Z. Wang, X. A. Li, W. D. D’Souza and R. D. Stewart, “Impact of prolonged fraction delivery times on tumor control: A note of caution for IMRT”, Int. J. Radiat. Oncol. Biol. Phys. 57, 543-552, 2003. N. Phaisangittisakul, L. Ma and W. D. D’Souza, “Magnetic collimation and metal foil filtering for electron range and fluence modulation”, Med Phys 31, 17-23, 2004. W. D. D’Souza, H. D. Thames and D. A. Kuban, “The dose-volume conundrum for response of prostate cancer to brachytherapy: summary dosimetric measures and their relationship to tumor-control probability”, Int J Radiat Oncol Biol Phys 58, 1540-1548, 2004. W. D. D’Souza, R. R. Meyer and L. Shi, “Selection of beam orientations in intensitymodulated radiation therapy using single-beam indices and integer programming”, Phys Med Biol 49, 3465-3481, 2004. W. D. D’Souza, A. A. Ahamad, R. B. Iyer, M. R. Salehpour, A. Jhingran and P. J. Eifel, “Feasibility of dose escalation using intensity-modulated radiation therapy in posthyterectomy cervical carcinomas”, Int J Radiat Oncol Biol Phys 61, 1062-1070, 2005. A. A. Ahamad, W. D. D’Souza, M. R. Salehpour, R. B. Iyer, H. D. Thames, S. L. Tucker, A. Jhingran, and P. J. Eifel, “Intensity-modulated radiation therapy after hysterectomy: comparison with conventional treatment and sensitivity of the normaltissue-sparing effect to margin size”, Int J Radiat Oncol Biol Phys, 62 1117-1124 2005.
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S. A. Naqvi* and W. D. D’Souza*, “A stochastic method for calculating dose distributions from respiration-induced intra-fraction motion during IMRT”, Med Phys 32, 1156-1163 2005. (*equal contributions) W. D. D’Souza, S. A. Naqvi, and C. X. Yu, “Real-time intra-fraction motion tracking using the treatment couch: a feasibility study”, Phys Med Biol 50, 4021-4033, 2005. S. A. Naqvi, W. D. D’Souza, M. A. Earl, S. J. Ye, R. Shih and X. A. Li, “Using a photon phase-space source for convolution/superposition dose calculations in radiation therapy”, Phys Med Biol, 50, 4111-4124 (2005). W. D. D’Souza, N. Zacharapoulos, M. Pepelea, P. Klahr and C. X. Yu, “Gated CT imaging using a free-breathing signal from flow-volume spirometry”, Med Phys 2005 32, 3641-3649 (2005). A. Gunawardena, W. D. D’Souza, L. Goadrich, R. R. Meyer, K. Sorensen, S. A. Naqvi, and L. Shi, “A difference matrix metaheuristic for intensity-map segmentation in stepand-shoot IMRT delivery”, Phys Med Biol 51, 2517-2536 (2006). W. D. D’Souza and T. J. McAvoy, “An analysis of the dynamics and control system for an intra-fraction motion synchronized treatment couch”, Med Phys 33, 4701-4709 (2006). J. Wu, O Dandekar, D. Nazareth, P Lei, W. D. D’Souza and R. Shekhar, “Effect of ultrasound probe on dose delivery during real-time ultrasound-guided tumor tracking”, Proc. IEEE Eng Med Biol Soc 1:3799-3802 (2006). W. D. D’Souza, D. P. Nazareth, C. Deyoung, Y. Kwok, M. Suntharalingam, W. F. Regine and C. X. Yu, “The use of gated and 4D CT imaging in treatment planning for stereotactic body radiotherapy”, Med Dosimetry 32, 92-101 (2007). R. R. Meyer, H. H. Zhang, L. Goadrich, D. P. Nazareth, L. Shi and W. D. D’Souza, “A multi-plan treatment planning framework: A paradigm shift for IMRT”, Int J Radiat Oncol Biol Phys, 68, 1178-1189 (2007). R. Shekhar, P. Lei, C. Castro-Pareja and W. D. D’Souza, “Automatic segmentation of phase-correlated lung CT scans through nonrigid image registration using geometrically regularized free-form deformation”, Med Phys 34, 3054-3066 (2007). P. Qiu, W. D. D’Souza, T. J. Mc Avoy, and K. J. R. Liu, “Inferential modeling and predictive feedback control in real-time motion compensation using the treatment couch during radiotherapy”, Phys Med Biol, 52, 5831-5854 (2007). J. Wu, H. Li, R. Shekhar, M. Suntharalingam and W. D. D’Souza, “An evaluation of planning techniques for stereotactic body radiation therapy in lung tumors”, Radiother Oncol 87, 35-43 (2008). S. Dieterich, K. Cleary, W. D. D’Souza, M. Murphy, K. Wong and P. Keall, “Locating and targeting moving tumors with radiation beams,” Med Phys 35, 5684-5694 (2008). W. D. D’Souza, H. H. Zhang, D. P. Nazareth, L. Shi and R. R. Meyer, “A nested partitions framework for beam angle selection in intensity-modulated radiation therapy”, Phys Med Biol 53, 3293-3307 (2008). H. H. Zhang, L. Shi, R. R. Meyer, D. P. Nazareth and W. D. D'Souza, “Solving beamangle selection and dose optimization simultaneously via high-throughput computing”, INFORMS: J Comput 21, 427-444 (2009). H. H. Zhang, W. D. D’Souza, R. R. Meyer, and L. Shi, “Modeling plan-related clinical complications using machine learning tools in a multi-plan IMRT framework”, Int J Radiat Oncol Biol Phys 74, 1617-1626 (2009).
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J. Wu, P. Lei, R. Shekhar, H. Li, M. Suntharalingam and W. D. D’Souza, “Do tumors in the lung deform during normal respiration? – an image registration investigation”, Int J Radiat Oncol Biol Phys 75, 268-275 (2009). W. D. D’Souza, K. Malinowski, S. Van Liew, G. D’Souza, K. Markham, T. J. McAvoy, M. Suntharalingam and W. F. Regine, “Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensation”, Acta Oncologica 48, 1198-1203 (2009). D. H. Lim, B. Yi, A. Mirmiran, A. Dhople, M. Suntharalingam and W. D. D’Souza, “Optimal beam arrangement for stereotactic body radiation therapy delivery in lung tumors”, Acta Oncologica 49, 219-224 (2010). G. D’Souza, H. H. Zhang, W. D. D’Souza, R. R. Meyer and M. L. Gillison, “Moderate predictive value of demographic and behavioral characteristics for diagnosis of HPV status in head and neck cancer”, Oral Oncol 46, 100-104 (2010). H. H. Zhang, J. Wu, S. A. Naqvi, R. R. Meyer, L. Shi and W. D. D’Souza, “A two-stage sequential linear programming approach to IMRT optimization”, Phys Med Biol 55, 883902 (2010). K. Malinowski, J. Pantorotto, S. Senan, T. J. McAvoy and W. D. D’Souza, “Inferring nodal volume and primary tumor positions from multiple anatomical surrogates using 4D CT in stage III lung cancer”, Int J Radiat Oncol Biol Phys 77, 1553-1560 (2010). H. H. Zhang, R. R. Meyer, L. Shi and W. D. D’Souza, “The minimum knowledge base for predicting organ-at-risk dose-volume levels and plan-related complications in IMRT planning”, Phys Med Biol 55, 1935-1947 (2010). E. Ataer-Cansizoglu, E. Bas, M. Yousuf, S. You, W.D. D’Souza and D. Erdogmus, “Towards respiration management in radiation treatment of lung tumors: transferring regions of interest from planning CT to kilovoltage X-ray images”, IEEE Eng Med Biol Soc. 3101-3104 (2010). J. Hou, M. Guerrero, W. Chen and W. D. D’Souza, “Deformable planning CT to conebeam CT image registration in head-and-neck cancer”, Med Phys 38, 2088-2094 (2011). K. T. Malinowski, T. J. McAvoy, R. George, S. Dieterich and W. D. D’Souza, “Incidence of changes in respiration-induced tumor motion and its relationship with respiratory surrogates during individual treatment fractions”, Int J Radiat Oncol Biol Phys 82, 1665-1773 (2012). K. T. Malinowski, T. J. McAvoy, R. George, S. Dieterich and W. D. D’Souza, “Mitigating errors in external respiratory surrogate-based models of tumor position”, Int J Radiat Oncol Biol Phys 82, e709-716 (2012). K. T. Malinowski, T. J. McAvoy, R. George, S. Dieterich and W. D. D’Souza, “Online monitoring and error detection of real-time tumor displacement prediction accuracy using statistical process control techniques”, Med Phys 39, 2042-2048 (2012). S. Tan, S. Kligerman, W. Chen, M. Lu, G. Kim, S. Feigenberg, W.D. D’Souza, M. Suntharalingam and W. Lu, “Spatial-Temporal [(18)F]FDG-PET features for predicting pathologic response of esophageal cancer to neoadjuvant chemoradiation therapy”, Int J Radiat Oncol Biol Phys 85, 1375-82 (2013). H. H. Zhang, S. Gao, W. Chen, L. Shi, W. D. D’Souza and R. R. Meyer, “A surrogatebased global search method for beam angle selection”, Phys Med Biol 58, 1933-46 (2013).
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Y. D. Mutaf, J. Zhang, B.Y. Yi, K. Prado, W. D. D'Souza, W. F. Regine and S. J. Feigenberg, “Dosimetric and geometric evaluation of a novel stereotactic radiotherapy device for breast cancer: The GammaPod”, Med Phys 40, 041722 (2013). J. Wu, C. Betzing , T.T. He, M. Fuss, W. D. D'Souza, “Dosimetric comparison of patient setup strategies in stereotactic body radiation therapy for lung cancer, Med Phys 40, 051709 (2013). K. T. Malinowski, T. J. McAvoy, R. George, S. Dieterich and W. D. D’Souza, “Maintaining Tumor Targeting Accuracy in Real-Time Motion Compensation Systems for Respiration-Induced Tumor Motion”, Med Phys 40, 071709 (2013). N. Mistry, A. Rosenkrantz, S. Roys, J. Papadimitrou, K. Siddiqui, M. Naslund, J. Borin, W. D’Souza, and R. P. Gullapalli, “Prostate Cancer: Detection using Multiparametric 1HMRI”, Mol Cell Pharmacol 5, 5-17 (2013). N. N. Mistry, T. Diwanji, X. Shi, S. Pokharel, S. Feigenberg, S. M. Scharf and W. D. D’Souza, “Evaluation of Fraction Regional Ventilation using 4D-CT and the Effects of Breathing Maneuvers on Ventilation”, Int J Radiat Oncol Biol Phys 87, 825-831 (2013). S. Tan, H. Zhang, Y. Zhang, W. Chen, W. D. D'Souza, and W. Lu, “Predicting Pathologic Tumor Response to Chemo-Radiotherapy with Histogram Distances Characterizing Longitudinal Changes in 18F-FDG Uptake Patterns”, Med Phys 40, 101707 (2013). H. H. Zhang, B. Y. Yi, G. T. Betzel and W. D. D'Souza, “Beam Controlled Arc Therapy A Delivery Concept for Stationary Targets”, Phys Med Biol 58, 7117-29 (2013). H. Zhang, S. Tan, W. Chen, S. Kligerman, G. Kim, W. D. D’Souza, M. Suntharalingam, and W. Lu, “Modeling Pathologic Response of Locally Advanced Esophageal Cancer to Chemoradiotherapy Using Spatial–Temporal 18F-FDG PET Features, Clinical Parameters, and Demographics”, Int J Radiat Oncol Biol Phys (in press) 2013. W. Lu, G. Neuner, R. George, Z. Wang, S. Sassor, W. F. Regine, S. J. Feigenberg and W. D. D’Souza, “Audio-Visual Biofeedback Does Not Improve the Reliability of Target Delineation using Maximum Intensity Projection (MIP) in 4DCT Radiotherapy Planning”, Int J Radiat Oncol Biol Phys (accepted) (2013). C. E. Rutter, Z. A. Husain, B. R. Mancini, S. A. Naqvi, B. Zhang, K. Marter, M. Koshy, A. Dhople, W. D. D'Souza and S. J. Feigenberg. “The use of heterogeneity corrections and it impact on delivered dose in patients treated with stereotactic body radiation therapy of the lung,” J Radiat Oncol (accepted) (2013). M. Xue, H. H. Zhang, S. Kligerman, P. Klahr, W. D. D’Souza and W. Lu, “Individually optimized uniform enhancement in CT angiography for the diagnosis of pulmonary thromboembolic disease – a simulation study,” Med Phys (in press) (2013). J. Hou, M. Guerrero, M. Suntharalingam, and W. D. D’Souza, “Response assessment in locally advanced head and neck cancer based on RECIST and volume measurements using cone beam CT images”, Tech Cancer Res Treat (accepted) (2013).
PEER REVIEWED ARTICLES (SHORT PAPERS AND PROCEEDINGS) 1.
B. R. Thomadsen and W. D. D’Souza, “Volume Determination”, in Volume & Kinetics In Tumor Control & Normal Tissue Complications, ed. by B. R. Paliwal, J. F. Fowler, D. E. Herbert, and M. P. Mehta, Proceedings of the Fifth International Conference on Dose, Time and Fractionation in Radiation Oncology, pp. 137-147, 1997.
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W. D. D’Souza, R. R. Meyer, M. C. Ferris and B. R. Thomadsen, “MIP models and BB Strategies in Brachytherapy Treatment Optimization,” Mathematical Programming Technical Report 99-08, University of Wisconsin, Madison, 1999. W. D. D’Souza, R. R. Meyer, and B. R. Thomadsen, “An iterative sequential mixedinteger programming approach to brachytherapy treatment plan optimization,” in The Use of Computers in Radiation Therapy, ed. by W. Schlegel and T. Bortfeld, Proceedings of the XIII International Conference on the Use of Computers in Radiation Therapy, pp. 480-482, 2000. R. R. Meyer, W. D. D’Souza, and B. R. Thomadsen, “Optimal brachytherapy treatment plans”, SIAM National Meeting, 2000. H. H. Zhang, W. D. D’Souza, L. Shi, and R. R. Meyer, “Machine Learning for the Prediction of Organ Damage from Cancer Radiotherapy”, 15th International Federation of Automatic Control Symposium on System Identification, SYSID, Saint-Malo, France, 2009. H. H. Zhang, L. Shi, R. R. Meyer, and W. D. D’Souza, “Machine Learning for Modeling Dose-Related Organ-at-Risk Complications after Radiation Therapy”, 8th International Conference on Machine Learning and Applications: Special Session on Machine Learning Methods for Modeling Treatment Outcomes in Cancer. Miami, Florida, December 13-15, 2009. W. D. D’Souza, K. Malinowski, and H. H. Zhang, “Machine Learning for Intra-Fraction Tumor Motion Modeling with Respiratory Surrogates”, 8th International Conference on Machine Learning and Applications: Special Session on Machine Learning Methods for Modeling Treatment Outcomes in Cancer. Miami, Florida, December 13-15, 2009. H. H. Zhang, W. D. D’Souza, L. Shi and R. R. Meyer. Machine Learning for modeling treatment-plan surface to predict complications after radiotherapy, 5th INFORMS Workshop on Data Mining and Health Informatics, Austin, Texas, November 6, 2010.
BOOK CHAPTERS 1. M. C. Ferris, R. R. Meyer and W. D. D’Souza, “Radiation treatment planning: mixed integer formulations and approaches”, in Handbook of Mathematical Modeling ed. G. Appa, L. Pitsoulis and H. P. Williams (Springer, NY) pp 308-314, 2006. 2. K. T. Malinowski and W. D. D’Souza, “Couch-Based Target Alignment”, in Adaptive Motion Compensation in Radiotherapy ed. Martin Murphy (Taylor and Francis) pp 3946, 2010. 3. H. H. Zhang, R. R. Meyer and W. D. D’Souza, “Machine Learning Applications in Radiation Therapy in Machine Learning Algorithms for Problem Solving in Computational Applications: Intelligent Techniques”, (IGI Global, Hershey, PA) pp. 5984, 2012.
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W. D. D’Souza, E. Madsen, B. Thomadsen and G. Frank, “Tissue mimicking materials for a multi-imaging modality prostate phantom”, Med. Phys. 25, A197, 1998 (AAPM 1998). P. Sinha, W. D. D’Souza, B. Thomadsen and M. Ritter, “Video capture of prostate ultrasound images and display in a 3D treatment planning computer”, Med. Phys. 25, A206, 1998 (AAPM 1998). W. D. D’Souza, R. R. Meyer, M. C. Ferris and B. R. Thomadsen, “Mixed integer programming models for prostate brachytherapy treatment optimization”, Med. Phys. 26, 1099, 1999 (AAPM 1999). W. D. D’Souza, R. R. Meyer and B. R. Thomadsen, “Dose homogeneity as a function of source strength in optimized treatment plans,” Med. Phys. 27, 1435, 2000 (AAPM 2000). W. D. D’Souza, M. B. Palmer, H. K. Lee, L. G. Smith and A. Pollack, “Is nomogrambased intraoperative overplanning of I-125 prostate implants necessary?”, (ASTRO 2001). H. K. Lee, D. A. Kuban, W. D. D’Souza, J. J. Yamal, L. G. Smith and A. Pollack, “Dosimetric consequences of using a surrogate urethra to estimate urethral dose after brachytherapy for prostate cancer”, (RSNA 2001). W. D. D’Souza and I. I. Rosen, “Variation of non-tumor integral dose in megavoltage photon beam treatment planning”, Med. Phys. 29, 1286, 2002 (AAPM 2002). W. D. D’Souza, A. Ahamad, R. B. Iyer, A. Jhingran, M. R. Salehpour and P. J. Eifel, “Feasibility of dose-escalation using IMRT in post-hysterectomy cervical carcinomas”, Med. Phys. 29, 1347, 2002 (AAPM 2002). A. Ahamad, W. D. D’Souza, S. L. Tucker, R. B. Iyer, M. R. Salehpour, A. Jhingran and P. J. Eifel, “Intensity modulated radiation therapy (IMRT) for post-hysterectomy pelvic radiation: selection of patients and planning target volume (PTV)”, (ASTRO 2002). W. D. D’Souza and H. D. Thames, “The dose-volume conundrum: is it better to underdose a small volume grossly or a large volume moderately”, (ASTRO 2002). S. Patel, W. D. D’Souza, M. Sarfaraz, M. Errens, B. Zhang and P. Amin, “Reirradiation for recurrent prostate cancer using urethral and rectal sparing 3D conformal radiation therapy”, (American Radium Society Meeting, 2003). W. D. D’Souza, M. Sarafaraz and S. A. Naqvi, “A comparison of two commercial IMRT treatment planning systems”, Med. Phys. 30, 1486, 2003 (AAPM 2003). J. Z. Wang, X. A. Li, W. D. D’Souza and R. Stewart, “Impact of prolonged dosedelivery times on tumor control: A note of caution for IMRT”, Med. Phys. 30, 1331, 2003 (AAPM 2003). W. D. D’Souza, R. R. Meyer, S. A. Naqvi and L. Shi, “Beam orientation optimization in IMRT using single beam characteristics and mixed-integer formulations”, Med. Phys. 30, 1341, 2003 (AAPM 2003). A. Gunawardena, R. R. Meyer, W. D. D’Souza, L. Shi, W. Yang and S. A. Naqvi, “A new leaf-sequencing algorithm using difference matrices reduces aperture number in IMRT”, Med. Phys. 30, 1347, 2003 (AAPM 2003). L. Ma, N. Phaisagittisakul and W. D. D’Souza, “Use of magnetically-collimated electrons and metal foil modulators for electron fluence and range modulation”, Med. Phys. 30, 1446, 2003 (AAPM 2003). 23
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W. D. D’Souza, C. L. Lee, S. Dibiase, P. P. Amin, C. X. Yu and W. F. Regine, “Quantifying systematic and random setup uncertainties using daily ultrasound-based localization during prostate radiotherapy”, Int J Radiat Oncol Biol Phys 57, S336, 2003 (ASTRO 2003). R. R. Meyer, A. Gunawardena, W. D. D’Souza, W. Yang, S. Naqvi and L. Shi, “Leaf sequencing via difference matrices reduces aperture number and beam-on time in IMRT”, Int J Radiat Oncol Biol Phys 57, S267-268, 2003 (ASTRO 2003). W. D. D’Souza, X. Wu and C. X. Yu, “4-D CT via breath-holds and pyramid-based nonlinear image registration”, Med. Phys. 31, 1778-1779, 2004 (AAPM 2004). S. A. Naqvi, W. D. D’Souza, M. Earl, and S. Ye, “Model-based methods for commissioning convolution/superposition codes for x-ray beam from linear accelerators”, Med. Phys. 31, 1813, 2004 (AAPM 2004). W. D. D’Souza, S. A. Naqvi, and C. X. Yu, “Intensity-modulated radiation therapy delivery using respiration motion-synchronized adaptive couch motion”, (ASTRO 2004). W. D. D’Souza, S. A. Naqvi, C. Yu, M. Suntha, and W. Regine, “Analysis of response time-delays in an adaptive feedback system: considerations for a real-time intra-fraction motion tracking couch”, Med Phys 32, 1920-1921, 2005 (AAPM 2005). W. D. D’Souza, S. A. Naqvi, and C. X. Yu, “Cumulated fraction effects on the interplay between MLC and respiration-induced intra-fraction motion during step-and-shoot IMRT and dynamic arc delivery”, Med Phys 32, 1922, 2005 (AAPM 2005). R. Shekhar, P. Lei, V. Walimbe, C. X. Yu, and W. D. D’Souza, “ A novel volume subdivision-based algorithm to register respiration phase-correlated lung CT images”, Med Phys 32, 2083, 2005 (AAPM 2005). S. A. Naqvi, W. D. D’Souza, and C. X. Yu, “ Assessing margins using a known tumor motion trajectory and a stochastic convolution/superposition algorithm”, Med Phys 32, 2095 (AAPM 2005). D. M. Shepard, D. Cao, M. Earl, S. A. Naqvi, and W. D. D’Souza, “Incorporating intrafraction motion into IMRT plan optimization”, Med Phys 32, 1975-1976 (AAPM 2005). W. D. D’Souza, C. Castro-Pareja, D. P. Nazareth, P. Lei and R. Shekhar, “Determination of cumulative intra-fraction dose using time weighted 3D dose distributions and deformable image registration”, (ASTRO 2005). D. P. Nazareth, H. H. Zhang, R. R. Meyer, L. Shi and W. D. D’Souza, “A Nested Partitions Framework for Beam Angle and Dose Optimization in IMRT”, Med Phys 33, 2056 (AAPM 2006). D. P. Nazareth, P. Klahr and W. D. D’Souza, “4D CT Using Retrospective VelocityBased Amplitude Sorting”, Med Phys 33, 2269 (AAPM 2006) (Reviewer’s Choice Finalist – Top 10 Abstract). J. Wu, D. P. Nazareth, C. Castro-Pareja, P. Lei, R. Shekhar and W. D. D’Souza, “4D Dose Calculation using 3D Elastic Dose Registration in Lung IMRT”, Med Phys 33, 2244 (AAPM 2006). S. Van Liew, T. J. McAvoy and W. D. D’Souza, “Real-time tumor tracking with a feedback-controlled treatment couch”, Med Phys 33, 2254 (AAPM 2006). W. D. D’Souza, D. P. Nazareth, S. A. Naqvi, and T. J. McAvoy, “Predicting dosimetric errors from real-time tumor tracking using a treatment couch during IMRT delivery”, Med Phys 33, 2045 (AAPM 2006).
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M. Afghan, D. Cao, M. Earl, S. Naqvi, and W. D. D’Souza, and D. Shepard, “Verification of a Monte-Carlo-based technique to correct for intrafraction organ motion”, Med Phys 33, 2293 (AAPM 2006). S. Van Liew, D. P. Nazareth, and W. D. D’Souza, “Determination and validation of a 4D trajectory for respiration-induced real-time tumor motion tracking”, Med Phys 33, 2030 (AAPM 2006). G. Zhang, K. J. Ha, B. Y. Yi, D. P. Nazareth, S. Van Liew, W. D. D’Souza, Z. Jiang, and C. X. Yu, “MLC tracking of respiration-induced target motion”, Med Phys 33, 2042 (AAPM 2006). S. Luan, C. Wang, D. Cao, D. Zhen, W. D. D’Souza, and C. X. Yu, “Patient Breathing Motion Synchronized IMAT: A New Technique for Compensating Intra-fraction Organ Motion”, Med Phys 33, 2043 (AAPM 2006). S. A. Naqvi and W. D. D’Souza, “Temporal correlation in Monte Carlo sampling to evaluate interplay between tumor and MLC motion in IMRT”, Med Phys 33, 2239 (AAPM 2006). J. Wu, H. Li, R. Shekhar and W. D. D’Souza, “Investigation of planning and delivery techniques for stereotactic body radiation therapy in lung tumors”, Med Phys 34, 2642 (AAPM 2007). J. Wu, R. Shekhar and W. D. D’Souza, “Do mobile tumors in the lung deform during normal respiration - an image registration investigation?”, Med Phys 34, 2573 (AAPM 2007). S. Van Liew, T. J. Mc Avoy, S. Dieterich and W. D. D’Souza, “Intra-fraction and interfraction real-time tumor motion prediction using multiple external surrogates”, Med Phys 34, 2529 (AAPM 2007). S. Van Liew, S. A. Naqvi and W. D. D’Souza, “A four-dimensional planning and MonteCarlo dose calculation framework for real-time tumor motion compensation”, Med Phys 34, 2368 (AAPM 2007). W. D. D’Souza, H. H. Zhang, D. P. Nazareth, L. Shi and R. R. Meyer, “Plan Space Modeling and Decision Support System for Multi-Plan IMRT Framework”, Med Phys 34, 2524 (AAPM 2007) (Reviewer’s Choice Finalist – Top 10 Abstract). H. H. Zhang, W. D. D’Souza, L. Shi and R. R. Meyer, “High-Throughput Computing in Condor Using a Nested Partitions Framework for IMRT Beam and Dose Optimization”, (AAPM 2007). W. D. D’Souza, S. Van Liew, T. J. Mc Avoy and R. P. Gullapalli, “Dynamic Imaging and Real-time Inferential Modeling of Liver Motion with External Surrogates and FastMRI”, (ASTRO 2007). S. Van Liew, R. George and W. D. D’Souza, “A statistical analysis of free-breathing and breath-coaching respiration signals”, (ASTRO 2007). W. D. D’Souza, H. H. Zhang, J. Wu, L. Shi and R. R. Meyer. “A "Slicing" Approach for IMRT Optimization Using Linear Programming”, Med Phys 35, 2868 (AAPM 2008). H. H. Zhang, R. R. Meyer, L. Shi and W. D. D’Souza, “Machine Learning Tools for Predicting Clinical Complications in a Multi-Plan IMRT framework”, Med Phys 35, 2854 (AAPM 2008) (Young Investigator Symposium Finalist). H. H. Zhang, R. R. Meyer, L. Shi and W. D. D’Souza, “A Unified Approach to Beam Angle Selection and Dose Optimization with High-Throughput Computing for IMRT”, Med Phys 35, 2867 (AAPM 2008).
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J. A. Tanyi, L. Ku, J. Wu, D. G. Kaurin, T. He, W. D. D’Souza and A. Hung, “Comparison of CBCT and Electromagnetic Transponders for Prostate Localization”, Med Phys 35, 2640 (AAPM 2008). J. Wu, M. Fuss and W. D. D’Souza, “Accumulated dose comparison in stereotactic body radiation therapy for lung tumors using three alignment strategies”, Int J Radiat Oncol Biol Phys 72, Supplement, S49 (ASTRO 2008). H. H. Zhang, W. D. D’Souza, R. R. Meyer, and L. Shi, “Solving Beam Angle Selection and Dose Optimization Simultaneously via High-Throughput Computing”, INFORMS Annual Meeting, 2008. (Pierskalla Prize Finalist). H. H. Zhang, W. D. D’Souza, R. R. Meyer, L. Shi. A “Slicing” Approach for IMRT Optimization Using Linear Programming”, INFORMS Annual Meeting, 2008. R. George, K. T. Malinowski, S. Dieterich and W. D. D’Souza, “On the Need for Multiple External Markers to Predict Tumor Displacement Due to Respiration”, Med Phys 36, 2725 (AAPM 2009). S. A. Naqvi, G. Lasio and W. D. D’Souza, “Time-Dependent Monte Carlo Dose Calculation Method for Dynamic Movement of All Linac Components in Presence of Patient Motion”, Med Phys 36, 2719 (AAPM 2009). K. T. Malinowski, T. J. McAvoy, R. George, S. Dieterich and W. D. D’Souza, “Ordinary Least Squares and Partial Least Squares for Intra-Fraction Lung Tumor Motion Modeling”, Med Phys 36, 2704 (AAPM 2009). K. T. Malinowski, J. R. Pantarotto, S. Senan, T. J. McAvoy and W. D. D’Souza, “Inferring Nodal Volume and Primary Tumor Positions From Multiple Anatomical Surrogates Using 4D CT in Stage III Lung Cancer”, Med Phys 36, 2704 (AAPM 2009). M. A. Yousuf, T. J. McAvoy and W. D. D’Souza, “Performance Characteristics of An Experimental Couch for Real-Time Tumor Motion Tracking”, Med Phys 36, 2676 (AAPM 2009). J. Wu, C. Betzing, A. Srisuthep, M. Fuss and W. D. D’Souza, “Tumor Volume Delineation: A Comparison of Imaging Protocols for Lung Tumors”, Med Phys 36, 2517 (AAPM 2009). H. H. Zhang, R. R. Meyer, L. Shi and W. D. D’Souza, “Minimum Multi-Plan IMRT Framework Knowledge Base for Predicting Organ-At-Risk Dose-Volume Levels and Complications”, Med Phys 36, 2633 (AAPM 2009). M. Afghan, D. Cao, M. Earl, S. Van Liew, S. A. Naqvi, W. D. D’Souza and D. M. Shepard, “Evaluation of An IMRT Planning Technique to Incorporate Intrafraction Organ Motion Using Rigid-Body Tumor Modeling”, Med Phys 36, 2561 (AAPM 2009). H. H. Zhang, R. R. Meyer, L. Shi, and W. D. D’Souza, “Minimum Knowledge Base for Predicting Organ-at-Risk Dose-Volume Levels and Complications”, INFORMS Annual Meeting, San Diego, California, October 11-14, 2009. W. D. D’Souza, R. R. Meyer, and H. H. Zhang, “A Two-Stage Approach to IMRT Dose Optimization”, INFORMS Annual Meeting, San Diego, California, October 11-14, 2009. R. R. Meyer, H. H. Zhang, and W. D. D’Souza, “Sequential Linear Programming for Large-Scale Dose Optimization”, INFORMS Annual Meeting, San Diego, California, October 11-14, 2009. K. T. Malinowski, T. J. McAvoy, R. George, S. Dietrich, and W. D. D’Souza, “Does respiration-induced tumor motion and its relationship with respiratory surrogates change during a treatment fraction?”, Int Radiat Oncol Biol Phys. 2009;75(3):S23.
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M. Yousuf, K. Malinowski, T. McAvoy, and W. D. D’Souza, “A novel treatment couch for real-time tracking of respiration-induced target motion: Evaluating its geometric accuracy”, Med Phys. 38, 3606 (AAPM 2011). M. Yousuf, K. Malinowski, S. A. Naqvi, and W. D. D’Souza, “Determining the optimal gating window size by considering the effect of tumor displacement on dose distributions”, Med Phys. 38, 3771 (AAPM 2011). M. Guerrero, H. H. Zhang, S. A. Naqvi, and W. D. D’Souza, “Jaw Tracking for Intensity Modulated Arc Therapy: Is There An Advantage?”, 52nd AAPM Annual Meeting, Philadelphia, Pennsylvania, July 18-22, 2010. H. H. Zhang, R. R. Meyer, S. A. Naqvi, L. Shi, and W. D. D’Souza, “The Role of IMRT and IMAT in Targets of Varying Complexity”, 52nd AAPM Annual Meeting, Philadelphia, Pennsylvania, July 18-22, 2010. K.T. Malinowski, TJ McAvoy, R George, S Dieterich, and W.D. D’Souza, “Online monitoring and error detection of real-time tumor displacement prediction accuracy using statistical process control”, Med Phys 37, 3430 (AAPM 2010). H. H. Zhang, R. R. Meyer, S. A. Naqvi, L. Shi, and W. D. D’Souza, “Clinical Evaluation of Fixed-Field IMRT Plans and IMAT Plans in Locally Advanced Head and Neck Cancer”, Med Phys 2010;78:, 52nd AAPM Annual Meeting, Philadelphia, Pennsylvania, July 18-22, 2010. W. Chen, H. H. Zhang, R. R. Meyer, L. Shi, and W. D. D’Souza, “Beam Angle Selection via Nested Partitions-Based Global Search Using a Fast Beam Set Scoring Process”, 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010. Z Wang, R George, W Lu, J Hou, and W. D. D’Souza, “Can We Predict the Severity of Artifacts On 4DCT From the Respiratory Irregularity During 4DCT Image Acquisition?”, W. D. D’Souza, M. A. Yousuf, K. T. Malinowski, T. J. McAvoy, H. H. Zhang and S. A. Naqvi, “Dosimetric Improvement via Real-Time Dynamic Couch-Based Intra-Fraction Motion Tracking for 3D conformal and IMRT Plans”, Int J Radiat Oncol Biol Phys 2010;78:S688. 52nd ASTRO Annual Meeting, San Diego, California, October 31November 4, 2010. H. H. Zhang, R. R. Meyer, S. A. Naqvi, L. Shi, and W. D. D’Souza, “Atlas-Based Dose Optimization via Linear Programming for IMRT Using a High-Throughput Computing Environment”, Int J Radiat Oncol Biol Phys 2010;78:S93. 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010. K.T. Malinowski, M.A. Yousuf, T.J. McAvoy, and W.D. D’Souza, “Integration of optical tracking with dynamic treatment couch real-time tracking for intra-fraction motion compensation”, Radiat Oncol Biol Phys. 2010;78(3):S698-9. 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010. W. Lu, G. Neuner, Z. Wang, R. George, J. Wu, S. Sassor, W. Regine, S. Feigenberg, and W. D. D’Souza, „Evaluating Inter-Fraction Variations in Tumor Volumes with Repeated 4DCT”, Int J Radiat Oncol Biol Phys 2010;78:S748-S749. 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010. G. A. Neuner, W. Lu, Z. Wang, S. Sassor, R. George, S. J. Feigenberg, W. F. Regine, and W. D. D’Souza, “Biofeedback during 4D-CT Image Acquisition Does Not Enhance the Reliability of ITVMIP for Radiation Treatment Planning of Thoracic and Abdominal Malignancies: A Prospective Trial”, Int J Radiat Oncol Biol Phys 2010;78:S671. 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010.
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C. Hung, Y. Kuo, J. E. Baulch, S. Raghavan, R. Gullapalli, M. Suntharalingam, and W. D. D’Souza, “Molecular Probes for Targeting and Imaging of the Epidermal Growth Factor Receptor”, Int J Radiat Oncol Biol Phys 2010;78:S163. 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010. W. Chen, H. H. Zhang, R. R. Meyer, L. Shi, and W. D. D’Souza, “Beam Angle Selection (BAS) via Nested Partitions-based Global Search using a Fast Beam Set Scoring Process”, Int J Radiat Oncol Biol Phys 78, S811-S812. 52nd ASTRO Annual Meeting, San Diego, California, October 31-November 4, 2010. R. R. Meyer, W. Chen, W. D. D’Souza, L. Shi, and H. H. Zhang, “Radiation Treatment Planning: Beam Angle Selection”, Proceedings of the INFORMS Annual Meeting, pp. 136 Austin, Texas, November 7-10, 2010. H. H. Zhang, W. D. D’Souza, R. R. Meyer, and L. Shi, “Cluster-Based Linear Program for Solving Large-Scale Radiation Treatment Planning Problem”, Proceedings of INFORMS Annual Meeting, pp. 137 Austin, Texas, November 7-10, 2010. H. H. Zhang, W. D. D’Souza, L. Shi, and R. R. Meyer, “Machine Learning for Modeling Treatment-Plan Surface to Predict Complications after Radiotherapy”, 5th INFORMS Workshop on Data Mining and Health Informatics, Austin, Texas, November 6, 2010. R. Meyer, S. Gao, W. Chen, L. Shi, W. D. D’Souza, and H. Zhang, “Machine Learning for Beam Angle Selection in Radiation Treatment Planning”, 9th International Conference on Machine Learning and Applications: Special Session on Machine Learning Methods in Cancer and Radiation Therapy. Washington D.C., December 12-14, 2010. KT Malinowski, TJ McAvoy, R George, S Dieterich, and WD D’Souza, “Mitigating Errors in Respiratory Surrogate-Based Models of Tumor Motion”, MAC-AAPM 2010. W. D. D’Souza, D Shah, T McAvoy, and K Malinowski, “Targeting Mobile Tumors Precisely with An Integrated Robotic Target Tracking and Dynamic Couch-Based Motion Compensation System for a Conventional Linear Accelerator”, Med Phys. 38, 3606 (AAPM 2011). J Hou, A Reese, H Zhang, and W. D. D’Souza, “Dosimetric Discrepancy Investigation with Cone-Beam CT for Adaptive RT of Head-And-Neck Cancer”, Med Phys. 38, 3444 (AAPM 2011). H Zhang, N Mistry, and W. D. D’Souza, “Beyond Utilizing Functional Imaging for Contours and Visualization, Towards Physiological Radiotherapy to Improve Patient Outcome”, Med Phys. 38, 3550 (AAPM 2011). M Guerrero, J Hou, and W. D. D’Souza, “Volume Regression: An Appropriate Surrogate for Treatment Response in Locally Advanced Head and Neck Cancer?”, Med Phys. 38, 3494 (AAPM 2011). H Zhang, and W. D. D’Souza, “Beam Controlled Arc Therapy: A Novel Delivery Concept for Stationary Targets”, Med Phys 38, 3739 (AAPM 2011). K Malinowski, T McAvoy, R George, S Dieterich, and W. D. D’Souza, “Selecting Training Data to Optimize Accuracy of Respiratory Surrogate-Based Tumor Displacement Models”, Med Phys. 38, 3771 (AAPM 2011). K Malinowski, T McAvoy, R George, S Dieterich, and W. D. D’Souza, “Maintaining Tumor Targeting Accuracy in Gating and Tracking Systems for Respiration-Induced Tumor Motion”, Med. Phys 38, 3782 (AAPM 2011). N Mistry, J Hou, R Ballard, S Feigenberg, and W. D. D’Souza, “Pulmonary Ventilation and Perfusion Imaging Using 4DCT”, Med Phys 38, 3831 (AAPM 2011).
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Y. Mutaf, J Zhang, B. Zhou, E. Nichols, C. X. Yu, B. Y. Yi, K. L. Prado, W. D. D’Souza, W. F. Regine, and S. J. Feigenberg, “Optimization of the Collimator Design for a Novel Stereotactic Radiotherapy Device for Breast Cancer”, Med Phys. 38, 3711 (AAPM 2011). S. Tan, W. Chen, M. Lu, G. Kim, S. Feigenberg, W. D. D’Souza, M. Suntharalingam, and W. Lu, “Spatial-Temporal PET-CT Features for Predicting Pathological Response of Esophagus Cancer to Chemo-Radiation Therapies”, Med Phys. 38, 3384 (AAPM 2011). N. N. Mistry, H. H. Zhang, R. Ballard, J. Hou, S. Feigenberg and W. D. D’Souza, “ High Resolution Regional Ventilation and Perfusion Imaging in the Lung using 4D-CT”, Int J Radiat Oncol Biol Phys 2011;81;S153 (ASTRO 2011). H. H. Zhang, W. D. D’Souza, N. N. Mistry and R. R. Meyer, “Organ function-based treatment planning”, Proceedings of the INFORMS Annual Meeting, pp.109 (2011). S. Tan, W. Chen, W. D. D’Souza, and W. Lu, “Compute the Optimal Threshold for PET Functional Volume Delineation” Med Phys. 39, 3678 (AAPM 2012). R. Meyer, S. Gao, L. Shi, W. D. D’Souza, and H. Zhang, “Utilizing Machine Learning Techniques for Beam Angle Selection in Radiation Treatment Planning”, Med Phys 39, 3846 (AAPM 2012). M. Xue, W. D. D’Souza, G. Lasio, P. Klahr, and W. Lu, “4D-CT Simulation Using Individually Optimized Contrast Enhancement (CE): A Phantom Study”, Med Phys 39, 3903 (AAPM 2012). W. D. D’Souza, T. Diwanji, N. Mistry, W. Lu, and H. H. Zhang, “Personalized Utility Function for Radiotherapy Based on Pulmonary Ventilation of Locally Advanced Lung Cancer Patients”, Med Phys 39, 3913 (AAPM 2012). T. Diwanji, S. Feigenberg, W. D. D’Souza, and N. Mistry, “Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) for High-Resolution Lung Perfusion Evaluation in Pulmonary Neoplasms Prior to Radiotherapy”, Med Phys 39, 3926 (AAPM 2012). K. Malinowski, T. Diwanji, T. McAvoy, and W. D. D’Souza., “Understanding the Performance of Control Limit-Based Monitoring of Respiratory Surrogate Tumor Motion Models”, Med Phys 39, 3923 (AAPM 2012). W. Lu, S. Tan, S. Kligerman, W. Chan, S. Feigenberg, H. Shang, M. Suntharalingam, and W. D. D’Souza, “Can Pre-Chemoradiotherapy FDG PET/CT Identify Residual Metabolically Active Areas Within Individual Esophageal Tumors?”, Med Phys 39, 3937 (AAPM 2012). T. Diwanji, S. Feigenberg, W. D. D’Souza, and N. Mistry, “Validation of 4D Computed Tomography (4D-CT) to Evaluate Fractional Regional Ventilation Against the Clinical Gold-Standard Scintigraphy V/Q”, Med Phys 39, 4017 (AAPM 2012). N. Mistry, S. Pokharel, T. Diwanji, S. Feigenberg, and W. D. D’Souza, “Breathing Maneuvers Result in Regional Changes in Ventilation as Assessed by 4D-CT”, Med Phys 39, 3605 (AAPM 2012). S. Tan, H. Zhang, S. Klingerman, W. Chen, G. Kim, S. Feigenberg, W. D. D’Souza, M. Suntharalingam, and W. Lu, “FDG-PET Histogram Distances: Novel Predictors of Tumor Response to Chemoradiotherapy”, Med Phys 39, 3615 (AAPM 2012). S. Tan, W. Chen, W. D. D’Souza, and W. Lu, “Compute the Optimal Threshold for PET Functional Volume Delineation”, Med Phys 39, 3678 (AAPM 2012).
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Y. Mutaf, C. Yu, J. Zhang, B. Yi, K. Prado, and W. D. D’Souza, “Dosimetric and Geometric Evaluation of a Novel Stereotactic Radiotherapy Device for Breast Cancer: The GammaPod”, Med Phys 39, 3796 (AAPM 2012). R. Meyer, S. Gao, L. Shi, W. D. D’Souza, and H. Zhang, “Utilizing Machine Learning Techniques for Beam Angle Selection in Radiation Treatment Planning” Med Phys 39, 3846 (AAPM 2012). W.D. D’Souza, D. Shah, K. Malinowski, and T.J. McAvoy, “Toward Intra-fraction Tumor Motion Tracking Using On-board Imaging and Dynamic Couch Compensation”, Int J Radiat Oncol Biol Phys 82, S153 (ASTRO 2012). A. S. Reese, J. Hou, M. Suntharalingam, and W.D. D’Souza, “Predicting Differences in Planned and Delivered Dose for Patients with Head and Neck Cancer Treated with Intensity Modulated Radiation Therapy”, Int J Radiat Oncol Biol Phys 82, S800 (ASTRO 2012). C. Hung, Y. Kuo, E. Choi, S. R. Raghavan, N. N. Mistry, R. Gullapalli, R. G. Lapidus, M. Suntharalingam, and W. D. D’ Souza, “Theranostic Nanoprobes for Targeting and Imaging of the Epidermal Growth Factor Receptor”, Int J Radiat Oncol Biol Phys 81, S143-S144 (ASTRO 2012). N. N. Mistry, H. H. Zhang, R. Ballard, J. Hou, S. Feigenberg, and W. D. D’ Souza, “High Resolution Regional Ventilation and Perfusion Imaging in the Lung using 4DCT”, Int J Radiat Oncol Biol Phys 82, S123-S124 (ASTRO 2012). H. H. Zhang, W. D. D’Souza, R. R. Meyer and L. Shi, “Iterative linear programming approach for IMRT optimization”, Proceedings of the INFORMS Annual Meeting, pp. 161 (2012). R. R. Meyer, W. D. D’Souza, S. Gao, L. Shi and H. H. Zhang, “Machine learning for beam angle selection in radiotherapy”, Proceedings of the INFORMS Annual Meeting, pp. 161 (2012). M. Xue, S. Tan, A. Reece, B. Y. Yi, W. D. D’Souza, S. Feigenberg and W. Lu, “InterFractional Tumor Motion Analysis Using 4D-CT and CBCT, Med Phys 40, 33 (AAPM 2013). X. Shi, t. Diwanji, S. Chen, W. D. D’Souza and N. N. Mistry, “Does combining lung ventilation information to perfusion provide any additional value for treatment planning?”, Med Phys 40, 35 (AAPM 2013). Y. Mutaf, C. X. Yu, B. Y. Yi, K. Prado, W. D. D’Souza, W. F. Regine and S. Feigenberg, “Localization accuracy of a novel prone breast stereotactic immobilization and localization system”, Med Phys 40, 27 (AAPM 2013). W. D. D’Souza, H. Ghaffari, X. Shi, N. N. Mistry and H. H. Zhang, “Functional imaging based radiotherapy for locally advanced lung cancer with motion management”, Med Phys 40, 29 (AAPM 2013). D. Stanojevic, W. D. D’Souza, R. R. Meyer and H. H. Zhang, “Population-based IMRT beam aperture shape inference using retrospective treatment plan and patient data”, Med Phys 40, 534 (AAPM 2013). X. Shi, T. Diwanji, K. Mooney, W. D. D’Souza and N. N. Mistry, “Error of template matching for tracking tumor motion is no larger than inter-operator variability”, Med Phys 40, 541 (AAPM 2013).
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C. Hung, Y. Kuo, E. Choi, N. N. Mistry, S. Raghavan, R. Lapidus, S. Xu, J. Zhuo and W. D. D’Souza, “ Multifunctional molecular probes for targeting and imaging of epidermal growth factors receptors in vivo”, Med Phys 40, 461 (AAPM 2013). H. H. Zhang, K. Prado, M. Mehta, W. F. Regine and W. D. D’Souza, “Achieving optimal treatment workflow configurations in multi-room proton centers via Monte Carlo simulations”, Med Phys 40, 42 (AAPM 2013). N. N. Mistry, C. Badea, R. Gullapalli, Z. Vujaskovic and W. D. D’Souza, “Extracting fractional regional ventilation in mice”, Med Phys 40, 513 (AAPM 2013). H. H. Zhang, D. Stanojevic, R. R. Meyer and W. D. D’Souza, “A patient populationbased approach for disease site specific intensity-modulated radiation therapy (IMRT) treatment planning”, Med Phys 40, 51 (AAPM 2013). Y. Kuo, C. Hung, S. Raghavan and W. D. D’Souza, “Imaging of targeted cancer therapy using multifunctional liposomal nanoprobes and MRI”, Med Phys 40, 539 (AAPM 2013). S. Chen, W. D. D’Souza, R. Gullapalli and N. N. Mistry, “Prediction of prostate gleason score using neural network and multi-parametric MRI”, Med Phys 40, 486 (AAPM 2013). K. Mooney, S. Chen, S. Feigenberg and W. D. D’Souza, “Assessing ITV and PTV coverage for mobile tumors with real-time fluoroscopy imaging”, Med Phys 40, 27 (AAPM 2013). M. Xue, H. Zhang, S. Kligerman, W. D. D’Souza, P. Klahr and W. Lu, “Individually optimized contrast injection in CT angiography for the diagnosis of pulmonary thromboembolic disease”, Med Phys 40, 483 (AAPM 2013). H. Zhang, H. Ghaffari and W. D. D’Souza, “A robust semi-infinite linear programming approach for radiotherapy planning”, Proceedings of INFORMS Healthcare pp. 23 (2013). D. Stanojevic, W. D. D’Souza, H. Zhang and R. R. Meyer, “A patient population based approach for disease site specific IMRT treatment planning”, Proceedings of INFORMS Healthcare pp. 30 (2013). Y. D. Mutaf, H. Chaudhry, C. X. Yu, B.Y. Yi, K. Prado, W. D. D'Souza, W. F. Regine and S. J. Feigenberg, “The dosimetric effect of tumor size and position in prone radiotherapy of breast using a novel stereotactic breast irradiation device: the GammaPodTM”, (ASTRO 2013). K. Mooney, G. Lasio, W. Lu, S.J. Feigenberg, W.F. Regine and W.D. D’Souza, “An approximate entropy-based method for prediction of 4D-CT quality from respiratory signals”, (ASTRO 2013). K. Mooney, S. Chen, S.J. Feigenberg, N.K. Sharma and W.D. D’Souza, “A populationbased treatment margin for respiratory motion of lung tumors”, (ASTRO 2013). X. Shi, S. Chen, W. D. D’Souza and N. N. Mistry, “Margins determined using 4DCT often underestimate tumor motion in thoracic tumors”, (ASTRO 2013). C. Sours, N. Mistry, H. Zhang, Y. Kwok, M. Mehta, W. Regine, W. D'Souza and R. Gullapalli, “Feasibility study testing the incorporation of resting state fMRI data in radiation therapy planning to limit dose to cognitive function networks in patients with primary brain tumors”, (ASTRO 2013). H. Ghaffari, X. Yang, W. D’Souza, B. Zhang and H. Zhang, “Assessing tumor coverage and organ-at-risk doses during intra-fraction motion via probability mass function of realtime respiratory trajectories”, (ASTRO 2013).
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H. Zhang, D. Anderson, B. Golden, N. Mistry, R. Gullapalli, M. Naslund, J. Wong and W. D’Souza, “Prostate cancer foci detection and aggressiveness identification using multiparametric MRI/MRS and supervised learning”, (ASTRO 2013). H. H. Zhang, K. Prado, K. M. Langen, M. P. Mehta, W. F. Regine and W. D. D'Souza, “Achieving Optimal Patient Setup Imaging and Treatment Workflow Configurations in Multi-Room Proton Centers via Monte Carlo Simulation”, (Radiological Society of North America Meeting 2013).
VISITING FACULTY LECTURES / INVITED SPEECHES Local 1.
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Department of Radiation Oncology, University of Maryland, Baltimore, MD. Non-tumor integral dose variation in conventional radiotherapy / Is the alpha-beta ratio for prostate low? / IMRT treatment planning in the female pelvis, November 2001. Department of Materials Science and Engineering, University of Maryland, College Park, MD. Respiration-induced tumor motion during radiation delivery, February 2005. American College of Medical Physics 24th Annual Meeting, Baltimore MD. IMRT: Organ at Risk Constraints, May 2007. Institute of Systems Research, A. James Clark College of Engineering, University of Maryland College Park, MD. Radiation Oncology – Present and Future: A medical physicist’s perspective, September 2009. Fischell Department of Bioengineering, A. James Clark College of Engineering, University of Maryland, College Park, MD Theranostics in cancer therapy, March 2010. Philips HealthCare Research Symposium, Cleveland, OH. A Decision Support System for IMRT, October 2010.
National 7.
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