Curriculum Vitae Young Kwok, M.D. Assistant Professor of Radiation Oncology University of Maryland School of Medicine Date:
July 14, 2009
Personal Information Young Kwok, MD Assistant Professor Dept of Radiation Oncology University of Maryland School of Medicine 22 South Greene St Baltimore, MD 21201 USA Email: ykwok@umm.edu Office: Clinic: Appointments: Fax:
(410) 328-9134 (410) 328-2929 (410) 328-6080 (410) 328-5279
Assistant: Charlotte Anderson Email: canderson@umm.edu Office: (410) 328-2324 Fax: (410) 328-5279 Education • Sept,1991 – June, 1995 •
Sept, 1995 – June, 1999
Johns Hopkins University, Baltimore, MD BA in Psychology, Departmental and General Honors Albert Einstein College of Medicine, Bronx, NY MD degree
Post Graduate Education and Training • July, 1999 – June, 2000 Internship in Internal Medicine – Beth Israel Medical Center, New York, NY •
July, 2000 – June, 2004
Employment • July, 2004 – Current
Clinical Privileges • 2004-Present • 2004-Present • 2004-Present • 2004-Present
Residency in Radiation Oncology – University of Maryland Medical Center,, Baltimore, MD Assistant Professor (tenure track) Department of Radiation Oncology University of Maryland Medical Center University of Maryland School of Medicine 22 S Greene St. Baltimore, MD 21201 University of Maryland Medical Center, Baltimore, MD Baltimore VA Medical Center, Baltimore, MD Maryland General Hospital, Baltimore, MD Montgomery General Hospital, Olney, MD
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2004-Present 2008-Present
Howard County General Hospital, Columbia, MD Baltimore-Washington Medical Center, Glen Burnie, MD
Certifications • 2006
American Board of Radiology
Medical Licensures • 2004
Maryland State License, active
Professional Memberships • 2000-2004 • 2000-2004 • 2000-Present • 2003-Present • 2004-Present • 2004-Present • 2004-Present • 2009-present
American College of Radiation Oncology American College of Radiology American Society for Therapeutic Radiology and Oncology American Brachytherapy Society American Society of Clinical Oncology Radiation Therapy Oncology Group Cancer and Leukemia Group B Children’s Oncology Group
Honors and Awards •
Undergraduate:
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Medical School: Residency:
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Assistant Professor:
Clinical Activities • Clinical Expertise:
–General and Departmental Honors –Full Academic Scholarship – Academic Dean’s List –1998: Travel Grant: American Society of Hematology, Miami Beach, Fl –2002: Radiologic Society of North America Roentgen Resident/Fellow Research Award –2003: Travel Grant: Radiation Therapy Oncology Group Meeting, New Orleans, La –2003-4:Chief Resident –2008: Teacher of the Year, Association of Residents in Radiation Oncology. –2008: Clinical Scholars Award: Cancer and Leukemia Group B (CALGB), Chicago, Il. –Genito-urinary malignancies, CNS tumors
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Technical Expertise:
–Intensity-Modulated Radiation Therapy (IMRT) –Image-Guided Radiation Therapy (IGRT) –Stereotactic Radiosurgery (SRS) • Gamma-knife • Trilogy –Fractionated Stereotactic Radiation Therapy (FSRT) –Stereotactic Body Radiation Therapy (SBRT) –Interstitial/Intracavitary Brachytherapy
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Scope of Practice:
–Large academic medical center (University of Maryland Medical Center) –250-300 patient consultations per year –150 patients treated per year –Responsible for heading up clinical research in GU and CNS Radiation Oncology
Administrative Service: Institutional • 2004-Present GU Tumor Board. Univ of Maryland Medical Center
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2004-Present 2004-Present
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2004-Present 2004-Present 2004-Present 2004-2006 2005-Present 2005-Present 2005-Present 2007-2008 2007-Present 2007-Present
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2007-Present
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April 2, 2008
Administrative Service: Local • 2004-2007 •
Tumor board leader since March 2007 Admissions Committee Interviewer, Univ of Maryland School of Medicine Internal Residency/Fellowship Review, Univ of Maryland School of Medicine 2004—Urology 2005—Interventional Cardiology Solid Tumor Board. Univ of Maryland Medical Center CNS Tumor Board. Univ of Maryland Medical Center Radiation Oncology Electronic Library. Univ of Maryland Medical Center Lymphoma Tumor Board. Univ of Maryland Medical Center Institutional Review Board, Univ of Maryland Medical Center Cancer Review Committee, Univ of Maryland Medical Center Technology Review Committee, Univ of Maryland Medical Center Base of Skull Tumor Board. Univ of Maryland Medical Center Head and Neck Tumor Board. Univ of Maryland Medical Center Ask the Expert. Spine-directed Oncology Program. Univ of Maryland Medical Center. http://www.umgcc.org/brain_tumor_center/spine-directed-oncology.htm Associate Director of Clinical Research. Dept of Radiation Oncology, Univ of Maryland Medical Center Department of Radiation Research Retreat: Coordinated a research retreat, which included the subdivisions of physics, biology, and clinical faculty, with the following objectives: i. To identify barriers and limitations that prevent effective clinical/translational research ii. To identify strategies to optimize effective interdepartmental research collaboration iii. To identify strategies to optimize effective inter-institutional research collaboration
Cancer Committee, Baltimore VA Medical Center, Baltimore, MD
White Oak Seminar Series: Coordinated a series of Radiation Oncology lectures at the FDA: Center for Devices and Radiological Health—The Federal Research Center @ White Oak, Silver Springs, MD o March 26, 2008 Speaker: Young Kwok, M.D. Topic: Recent Advances in Radiation Oncology o
April 30, 2008
Speaker: Topic:
Michael Garofalo, M.D. Liver-directed Therapy
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May 28, 2008
Speaker: Topic:
Majid Mohiuddin, M.D. Recent Advances in Breast Cancer
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August 27, 2008
Speaker: Topic:
William Regine, M.D. Brain Metastases Management
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September 24, 2008
Speaker: Topic:
Anil Dhople, M.D. Stereotactic Body Radiation Therapy
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February 25, 2009
Speaker: Topic:
Pradip Amin, M.D. Brachytherapy
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2009-
Cancer Interest Group, Univ of Maryland School of Medicine
Administrative Service: National/International • 2005-Present Genito-urinary & Radiation Oncology Committees, Cancer and Leukemia Group B (CALGB), Chicago, Il • • • • • • • •
2003-present 2004-present 2005-present 2005-present 2006-present 2007-present 2007-present 2008-present
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University of Maryland Annual Radiobiology, Physics Review Course: Annual review course for the Radiation Oncology Written Board Exam attended by majority of the residents throughout the country. 1. April 28-30, 2006 Co-coordinator 2. May 3-6, 2007 Co-coordinator
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American Board of Radiology (Radiation Oncology) 1. 2007 Genito-urinary written board examination writer 2. 2008 Genito-urinary written board examination writer
Reviewer, Technology in Cancer Research and Treatment Reviewer, American Journal of Clinical Oncology Reviewer, International Journal of Radiation Oncology Biology Physics Reviewer, Journal of Clinical Oncology Reviewer, Spinal Cord Reviewer, International Journal for Quality in Health Care Reviewer, The Lancet Oncology Reviewer, Lung Cancer
Teaching Service • Medical School Lectures (Univ of Maryland School of Medicine) 1. 2001-Present Discussion Group Facilitator for second year medical school small group in oncology, one 2 hour class per year •
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Graduate School Lectures (Univ of Maryland--Baltimore) 1. Fall 2008 GPIL 665 course—Special Topics in Cancer Biology o Contemporary Management of Glioblastoma. 1.5hr lecture--October 27, 2008 o Course Director: Feyruz Rassool, Ph.D. o Graduate Student Mentees: a. Dipika Germani, Final Project: Alternatives strategies in overcoming imatinib resistance in chronic myeloid leukemia patients. b. Amanda Graner, Final Project: The Role of the t(4; 14)(p16; q32) Translocation in Multiple Myeloma Ph.D. Dissertation Committee (Univ of Maryland School of Pharmacy) 1. Fall 2008-Present o Candidate: Nneka Onwudiwe o Title: Breast Conserving Surgery: Event Free Survival and Costs Subsequent to Radiation Therapy o Advisors: Ebere Onukwugha, Ph.D., C Daniel Mullins, Ph.D. o Proposal Defense: May 5, 2009 Resident Lectures 1. April 20, 2005 Pediatric Medulloblastoma. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 2. June 12, 2007 Metastatic Spinal Cord Compression. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD
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November 20, 2007 Medulloblastoma. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 4. December 4, 2007 Predictors of Outcome in Prostate Cancer. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 5. January 2, 2008 Jeopardy: Genito-urinary Cancers. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 6. October 7, 2008 Contemporary Management of Non-metastatic Prostate Cancer. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 7. October 23, 2008 Contemporary Management of Non-metastatic Prostate Cancer. Grand Rounds. Division of Urology, Univ of Maryland Medical Center, Baltimore, MD 8. October 27, 2008 Contemporary Management of Glioblastoma. GPIL 665 course— Special Topics in Cancer Biology. Univ of Maryland School of Medicine, Baltimore, MD 9. October 28, 2008 Jeopardy: Genito-urinary Cancers. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 10. April 22, 2009 Radiation Sensitizers in Metastasis . Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 11. April 29, 2009 Jeopardy: Central Nervous System. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD
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University of Maryland Dosimetry School Lectures 1. October 25, 2004 CNS Dosimetry-Treatment Planning 2. April 23, 2008 CNS Tumors 3. November 5, 2008 Base of Skull Tumors I 4. November 12, 2008 Base of Skull Tumors II
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Radiation Oncology Mock Oral Preparatory Exams 1. September 21, 2005 Genito-urinary. Anil Dhople MD. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 2. October 24, 2006 Genito-urinary. Todd Flannery MD. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 3. January 17, 2007 Central Nervous System. Todd Flannery MD. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD 4. November 28, 2007 Genito-urinary. Ashish Patel MD. Department of Radiation Oncology, Univ of Maryland School of Medicine, Baltimore, MD
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Student Research Sponsorships/Mentorships 1. 2002-2003 Stephen Ronson, MS IV—Incidence and temporal pattern of hematuria and proteinuria in men treated with permanent interstitial prostate brachytherapy. Presented at the American Radium Society, Houston, Tx, April 2003. Matched residency in Radiation Oncology at Loma Linda Hospital, CA. 2. 2003-2004 Neeraja Murali, BA—Long-term Results of Gamma Knife Stereotactic Radiosurgery for Non-functioning Pituitary Adenomas. Presented at the American Society of Therapeutic Radiology and Oncology, Atlanta, Ga October 2004. Entered graduate program in Epidemiology at Emory University, GA. 3. 2003-2004 Susannah Yovino, MS IV—Preoperative Anemia is Associated with Decreased Survival in Patients with Stage I and II Non-Small-Cell Lung Cancer Treated with Surgery. Presented at the American Society of Therapeutic Radiology and Oncology, Atlanta, Ga October 2004, Manuscript published in International Journal of Radiation Oncology Biology Physics, 2005. Matched in residency program in Radiation Oncology at University of Maryland School of Medicine, MD. 4. 2005 Daniel Lerman, MS II—Long-term outcome of patients with vestibular schwannoma treated with Gamma-Knife stereotactic radiosurgery.
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2005-2007 Owen Thomas, MS III— Long-term outcome of Gamma-Knife stereotactic radiosurgery for brain metastasis from radio-resistant tumors (melanoma, sarcoma, renal-cell carcinoma). Matched in residency program in Radiation Oncology at Johns Hopkins Hospital, MD 6. 2005-2007 Lara Bonner, MS III—Hematuria and Proteinuria in men treated with prostate brachytherapy. Matched in residency program in Radiation Oncology at University of Pennsylvania Hospital, PA 7. 2006-2007 Elizabeth Nichols, MS III—Long-term outcome of patients with vestibular schwannoma treated with Gamma-Knife stereotactic radiosurgery. Matched in residency program in Radiation Oncology at University of Maryland Medical Center, MD 8. 2008, Summer Charles Rutter, MS I—Recipient of Simon Kramer Externship award (summer of 2008) 9. 2009, Summer Tejan Diwanji, MS I—Summer Fellowship Award in Radiation Oncology. Long-term outcome of multiple sclerosis patients with trigeminal neuralgia treated with Gamma-Knife stereotactic radiosurgery. 10. 2009, Summer Sean Gao, Johns Hopkins Undergraduate Student—Clinical Shadowing. 11. 2009, Summer Sonu Bassi, Severn High School—High-risk prostate cancer. •
Radiation Oncology Resident Research Sponsorships 1. 2003-2004 Pinaki Dutta, MD—Comparison of Repeat GK-SRS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter? Presented at the American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004. 2. 2004-2005 Anil Dhople, MD—Evaluation of Efficacy and Quality of Life in Patients with Atypical Facial Pain Treated with Gamma-Knife Stereotactic Radiosurgery. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005. Manuscript published. 3. 2005-2006 Shilpen Patel, MD—Evaluating the influence of dose-rate on outcome with gamma-knife stereotactic radiosurgery in the treatment of trigeminal neuralgia. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co. October 2005. 4. 2005-present Susannah Yovino, MD—Long-term outcome of breast cancer patients treated with Gamma-Knife stereotactic radiosurgery for brain metastasis. Oral Presenation at Radiologic Society of North America, Chicago 2006. 5. 2005-2006 Kathleen Settle, MD—A Volumetric Study of Needle’s Eye View CT scan in Predicting Pubic Arch Interference and Intra-operative Prostate Volume in Men Undergoing Permanent Interstitial Prostate Brachytherapy. 6. 2005-2007 Anil Dhople, MD—Long-term outcome of Gamma-Knife stereotactic radiosurgery for brain metastasis from radio-resistant tumors (melanoma, sarcoma, renal-cell carcinoma). 7. 2005-2008 Todd Flannery, MD—Long-term Results of Intermediate and HighRisk Prostate Cancer Patients Treated with Prostate Brachytherapy. (Resident Travel Award for Dr. Flannery) at American Brachytherapy Society, Philadelphia, PA, May 2006. 8. 2005-2007 Todd Flannery, MD—The Impact of Definitive Thoracic Management on Long-Term Survival in Patients with Synchronous, Solitary Brain Metastases from Non-Small Cell Lung Cancer Treated with Stereotactic Radiosurgery. Manuscript published. 9. 2007-present Usama Mahmood, MD—Dosimetric Analysis of Cesium-131 Brachytherapy. Poster Discussion at American Brachytherapy Society, Boston, MA, May 2008. 10. 2007-present Ashish Patel, MD—University of Maryland Experience of Gliasite Brachytherapy in Recurrents High-grade Gliomas. Poster Discussion at Radiologic Society of North America 2008. 11. 2007-present Ali Mirmiran, MD—Long-term Toxicity Data of a Prospective Phase I/II Trial of Concurrent Paclitaxel and Radiation for High-risk or Post-operative Prostate Cancer. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Boston 2008.
Active Grant Support 1. June 01, 2006 – present: • •
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Principle Investigator (5%) Protocol Title: Phase II Study Evaluating Bone Marrow-Sparing, Image-Guided Pelvic Intensity-Modulated Radiotherapy (IMRT) with Cesium-131 Brachytherapy Boost, Adjuvant Chemotherapy, and LongTerm Hormonal Ablation in Patients with High Risk, Non-Metastatic Prostate Cancer. Industry Grant Sponsor—Isoray Corp., Richland, WA Total Direct and Indirect Costs: $200,000
Active Clinical Trials Principle Investigator 1. GCC 0605: Phase II Study Evaluating Bone Marrow-Sparing, Image-Guided Pelvic IntensityModulated Radiotherapy (IMRT) with Cesium-131 Brachytherapy Boost, Adjuvant Chemotherapy, and Long-Term Hormonal Ablation in Patients with High Risk, Non-Metastatic Prostate Cancer. o Funded Clinical Trial o Opened: June 2006 o Currently enrolling patients 2.
Retrospective Chart Review of Patients who have undergone Permanent Interstitial Prostate Brachytherapy to Study the Correlation Between Pre-Operative CT Scan Beams-Eye-View Prostate Volume with Real-Time Intraoperative Ultrasound Prostate Volumes o Opened: 2005 o Closed to accrual 2008
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GCC 0501: Retrospective Review of stereotactic Radiosurgery Treatments of Benign, Primary and Metastatic Lesions: A University of Maryland Experience. o Opened: 2005 o Closed to accrual 2008
Institutional PI of National/International Protocols 1. RTOG 0320: A Phase III Trial Comparing Whole Brain Radiation and Stereotactic Radiosurgery Alone Versus with Temozolomide or Erlotinib in Patients with Non Small Cell Lung Cancer and 1-3 Brain Metastases o Opened: Nov 2006 o Currently enrolling patients 2.
RTOG 0415: A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT versus Conventionally fractionated 3D-CRT/IMRT in Patients with Favorable-risk Prostate Cancer. o Opened: Feb 2007 o Currently enrolling patients
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RTOG 0424: A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas o Opened: Oct 2005 o Currently enrolling patients
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RTOG 0526: A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy o Opened: May 2008 o Currently enrolling patients
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RTOG 0534: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy o Opened: April 2008 o Currently enrolling patients
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RTOG 0614: A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy o Opened: June 2008 o Currently enrolling patients
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RTOG 0513: A Phase I/II Trial of Temozolomide, Motexafin Gadolinium, and 60 Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme o Opened: September 2008 o Currently enrolling patients
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RTOG 0621: Adjuvant 3DCRT/IMRT in Combination with Androgen Suppression and Docetaxel for High Risk Prostate Cancer Patients Post-Prostatectomy: A Phase II Trial o Opened: October 2008 o Currently enrolling patients
Publications 1. Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S. Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy. International Journal of Radiation Oncology Biology Physics 2002, 53(3), 588-594. 2.
Flannery T, Suntharalingam M, Kwok Y, Koffman B, Amin P, Chin L, Nicol B, Fowler B, Young AB, Regine W. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer 2003, 42, 327-333.
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Thomas L, Kwok Y, Edelman M. Management of paraneoplastic syndromes in lung cancer. Current Treatment Options in Oncology 2004, 5(1), 51-62.
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Herman JM, Petit JH, Amin P, Kwok Y, Dutta P, Chin LS. Repeat gamma knife radiosurgery for refractory or recurrent trigeminal neuralgia: Treatment outcomes and quality of life assessment. International Journal of Radiation Oncology Biology Physics 2004, 59(1), 126-133.
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Garofalo M, Kwok Y, Regine WF. The Evolving Role of Adjuvant Postoperative Radiation Therapy. Surgical Oncology Clinics of North America 2004 Oct;13(4):589-604, viii.
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Patel AB, Edelman MJ, Kwok Y, Krasna M, Suntharalingam M. Predictors of acute esophagitis in patients with non-small cell lung carcinoma treated with concurrent chemotherapy and hyperfractionated radiation therapy followed by surgery. International Journal of Radiation Oncology Biology Physics 2004 Nov;60(4),1106-12.
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DiBiase S, Kwok Y, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. International Journal of Radiation Oncology Biology Physics 2004 Nov 15;60(4):1106-12.
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Kwok Y, Regine WF, Patchell RA. Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo. Journal of Clinical Oncology 2005 May 20;23(15):3308-10. Epub 2005 Feb 28.]
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Kwok Y, Regine W, Dibiase SJ. In reply to Dr. Rogers et al. International Journal of Radiation Oncology Biology Physics 2005 Jun 1;62(2):618-9.
10. Yovino S, Kwok Y, Krasna M, Bangalore M, Suntha M. An association between preoperative anemia and decreased survival in early-stage non-small cell lung cancer treated with surgery alone. International Journal of Radiation Oncology Biology Physics 2005 Aug 1;62(5):1438-4. 11. Ma L, Kwok Y, Chin LS, Simard JM, Regine WF. Concomitant GRID boost for Gamma Knife radiosurgery. Medical Physics 2005 Nov;32(11):3419-23. 12. Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife radiosurgery for trigeminal neuralgia treatments. Phys Med Biol 2005 Nov 21;50(22):5217-27. Epub 2005 Oct 24. 13. D’Souza W, Kwok Y, DeYoung C, Zacharapoulos N, Pepelea M, Klahr P, and Yu CX. Gated CT imaging using a free-breathing respiration signal from flow-volume spirometry. Medical Physics 2005 Dec;32(12):3641-49. 14. Kwok Y, DeYoung C, Garofalo M, Dhople A, and Regine W. Radiation Oncology Emergencies. Hematology/Oncology Clinics of North America April 2006;20(2):505-522. 15. Kwok Y, Patchell RA. Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.” Doh, Amato, Paulino et al. Oncology May 2006;20(6):619-625. 16. Kwok Y, Tibbs PA, Patchell RA. Clinical approach to metastatic epidural spinal cord compression. Hematology/Oncology Clinics of North America Dec 2006;20(6):1297-1305. 17. D’Souza W, Nazareth D, Zhang B, Deyoung C, Suntharalingam M, Kwok Y, Yu CX, and Regine W. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy. Medical Dosimetry 2007 Summer;32(2):92-101 18. Dhople A, Kwok L, Chin L, et al. Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery. Int J Radiat Oncol Biol Phys 2007;69(2):397-403. Epub 2007 Apr 30. 19. Flannery TW,Suntharalingam M, Regine WF, Chin LS, Krasna MJ, Shehata MK, Edelman MJ, Kremer M, Patchell RA, and Kwok Y. Long-term survival in patients with synchronous, solitary brain metastasis from non-small cell lung cancer treated with radiosurgery. Int J Radiat Oncol Biol Phys 2008 Sept 1;72(1):19-23. Epub 2008 Feb 13. [senior author] 20. Dhople AA, Adams JR, Maggio WW, Naqvi SA, Regine WF, and Kwok Y. Long Term Outcomes of Gamma-Knife Radiosurgery for Classic Trigeminal Neuralgia: Implications of Treatment and Critical Review of the Literature. J Neurosurg 2009: 1-8. Epub 2009 March 27. [senior author] 21. Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Carter K, Ord R, Zimrin A, Strome S, and Suntharalingam M. Race impacts outcome in stage III/IV squamous cell carcinomas of the head and neck after concurrent chemoradiation therapy. Cancer 2009; 115(8):1744-52. 22. Yovino S, Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Ord R, Zimrin A, Strome S,and Suntharalingam M. Patterns of failure among patients with squamous cell carcinoma of the head and neck who obtain a complete response to chemoradiotherapy. Head Neck 2009 May 29. [Epub ahead of print] Book Chapters:
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Kwok Y, Garofalo M, Regine WF. Postoperative Adjuvant Therapy for Pancreatic Cancer. In: Pancreatic Cancer. Von Hoff DD, Evans DB, and Hruban RH (ch.27, p395-404). Sudbury, MA: Jones and Barlett, 2005.
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Kwok Y, Patchell RA, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Principles and Practice of Radiation Oncology (ch.91, p1974-1985). Lippincott Williams & Wilkins; 5th edition. 2007.
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Miker-Zabel S, Kwok Y, Debus J. Skull Base Tumors. In: Principles and Practice of Stereotactic Radiosurgery (ch.37, p383-392). Springer; 1st edition. 2008
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Chin LS, Patel S, Mattingly T, Kwok Y. Trigeminal Neuralgia. In: Principles and Practice of Stereotactic Radiosurgery (ch.52, p519-526). Springer; 1st edition. 2008
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Kwok Y, Patchell RA, Regine WF. Management of Overt CNS Metastases: Brain and Spinal Cord. Lung Cancer: Principles and Practice. Lippincott Williams & Wilkins; 4th edition. 2009.
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Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: ALERT: Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. Rubin P, Constine L, Marks L, Williams J, Hansen J. New York, NY: Springer-Verlag, 2010.
Abstracts (Selected): 1. Kwok Y, Lanzkowsky P, Karayalcin G. Childhood neutropenias: A fifteen year experience. Poster Presentation at American Society of Hematology, Miami, Fl, December 1998. 2.
Kennedy A, Murthy R, Kwok Y, Kanani S, Tucker G, Desai K, van Echo D. Preliminary results of outpatient hepatic artery brachytherapy for colorectal hepatic metastases. Oral Presentation at European Cancer Conference, Lisbon, Portugal, October 2001.
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Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S. Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy. Oral Presentation at Radiological Society of North America, Chicago, Il, October 2001.
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Kennedy A, Murthy R, Kwok Y, Tucker G, Kanani S, Desai K, van Echo D. Hepatic artery brachytherapy for unresectable hepatocellular carcinoma: an outpatient treatment approach. Oral Presentation at Internation Congress on Anti-Cancer Treatment, Paris, France, February 2002.
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Kwok Y, Suntharalingam M, Taylor R, Baig F, Yaes R, Mohiuddin M, Regine W. A definitive evaluation of the impact of treatment related factors on local control in patients with T1 glottic tumors utilizing Linear-Quadratic Plus Time model. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2002.
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Kennedy A, Yovino S, Kwok Y, Duckham E, van Echo D. Long-term follow-up of upper GI cancers after conformal radiotherapy combined with paclitaxel or capecitabine plus paclitaxel. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2002.
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Ronson S, DiBiase S, Kwok Y, Amin P, Naslund M, Jacobs S. Incidence and temporal pattern of hematuria and proteinuria in men treated with permanent interstitial prostate brachytherapy. Poster Presentation at American Radium Society, Houston, Tx, April 2003.
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Kwok Y, DiBiase S, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Improved outcome with adequate dural tail coverage in patients with intracranial meningiomas treated with Gamma Knife stereotactice radiosurgery. Poster Discussion at American Society of Therapeutic Radiology and Oncology, Salt Lake City, Ut, October 2003
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Kennedy A, Kwok Y, Batko-Yovino S, van Echo D. A phase I study of preoperative capecitabine, irinotecan concurrent with radiation therapy for resectable rectal cancer. Poster Presentation. American Society of Clinical Oncology GI Symposium, San Francisco, Ca, January 2003.
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Yovino S, BA, Kwok Y, Krasna M, Bangalore M, Suntha M. Preoperative Anemia Decreases Survival in Patients with Stage I and II Non-Small-Cell Lung Cancer Treated with Surgery. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004.
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Kwok Y, Murali N, Chin L, Bangalore M, Amin P, and Regine W. Long-term Results of Gamma Knife Stereotactic Radiosurgery for Non-functioning Pituitary Adenomas. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004.
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Dutta, P.R., Kwok Y, Chin, L.S., Herman, J.M., Colliver, C., St. Clair, W., Petit, J., Young, B., and Regine, W.F. Comparison of Repeat GK-SRS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter? Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004.
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Sullivan P, Ord R, Gray W, Wolf J, Taylor R, VanEcho D, Kwok Y, Suntharalingam M. Long-term survival and functional quality of life assessments in patients with locally advanced unresectable squamous cell carcinomas of the head and neck treated with concurrent chemoradiation. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004.
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Patel S, Kwok Y, Shepard D, Chin L, Slawson R, Amin P, and Regine W. Evaluating the influence of dose-rate on outcome with gamma-knife stereotactic radiosurgery in the treatment of trigeminal neuralgia. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005.
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SJ DiBiase, N Dawson, Y Kwok, R Kataria, A Hussain, S Nagda, M Bangalore, P Amin. Phase II Trial of External Radiotherapy, Brachytherapy, Androgen Deprivation, and Docetaxel Chemotherapy for High-Risk, Localized Prostate Cancer. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005.
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Dhople A, Kwok Y, Jaboin J, Chin L, Slawson R, Amin P and Regine W. Evaluation of Efficacy and Quality of Life in Patients with Atypical Facial Pain Treated with Gamma-Knife Stereotactic Radiosurgery. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005.
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Flannery T, Kwok Y, Naslund M, and Amin P. Long-term Results of Intermediate and High-Risk Prostate Cancer Patients Treated with Prostate Brachytherapy. Poster Presentation (Resident Travel Grant for Todd Flannery, M.D.) at American Brachytherapy Society, Philadelphia, PA, May 2006.
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Flannery T, Kwok Y, Krasna L, Chin L, Shehata M, Kremer M, Jaboin J, Suntha M, Regine W. The Impact of Definitive Thoracic Management on Long-Term Survival in Patients with Synchronous, Solitary Brain Metastases from Non-Small Cell Lung Cancer Treated with Stereotactic Radiosurgery. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Philadelphia, Pa, November 2006.
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Thomas O, Kwok Y, Dhople A, Chin L, Slawson, Regine W, Long-term outcome of patients treated with Gamma Knife stereotactic radiosurgery for brain metastases secondary to malignant melanoma or renal cell carcinoma. Poster Presentation at Radiological Society of North America, Chicago, Il, November 2006.
20.
Kwok Y, Gutt R, Yovino S, Chin L, Tkaczuk K, and Regine W. Long-term outcome of breast cancer patients with brain metastasis treated with Gamma Knife stereotactic radiosurgery. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2006.
21.
Kwok Y, M Won, WF Regine, M Mehta, F Schmitt, RA Patchell, and D Watkins-Bruner. Neurocognitive Impact of Whole Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR-0018. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, Ca, October 2007.
22.
Kwok Y, M Won, WF Regine, M Mehta, F Schmitt, RA Patchell, and D Watkins-Bruner. Neurocognitive Impact of Whole Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR-0018. Oral Presentation at Radiation Therapy and Oncology Group, San Diego, Ca, January 19, 2008.
23.
Kwok Y, Kataria R, Amin P, Naslund M, Hussain A, Dawson n, and Dibiase S. Long-term Results of a Prospective Phase II Trial of Androgen Ablation, Pelvic External Beam Radiation Therapy, Brachytherapy Boost, and Adjuvant Docetaxel in High-risk Prostate Cancer. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Boston, Ma, September 2008.
Presentations: 1. Kwok Y, Lanzkowsky P, Karayalcin G. Childhood neutropenias: A fifteen year experience. Poster Presentation at American Society of Hematology, Miami, Fl, December 1998. 2.
Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S. Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy. Oral Presentation at Radiological Society of North America, Chicago, Il, October 2001.
3.
Kwok Y, Suntharalingam M, Taylor R, Baig F, Yaes R, Mohiuddin M, Regine W. A definitive evaluation of the impact of treatment related factors on local control in patients with T1 glottic tumors utilizing Linear-Quadratic Plus Time model. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2002.
4.
Kwok Y, DiBiase S, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Improved outcome with adequate dural tail coverage in patients with intracranial meningiomas treated with Gamma Knife stereotactice radiosurgery. Poster Discussion at American Society of Therapeutic Radiology and Oncology, Salt Lake City, Ut, October 2003.
5.
Kwok Y, Murali N, Chin L, Bangalore M, Amin P, and Regine W. Long-term Results of Gamma Knife Stereotactic Radiosurgery for Non-functioning Pituitary Adenomas. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004.
6.
Kwok Y, Gutt R, Yovino S, Chin L, Tkaczuk K, and Regine W. Long-term outcome of breast cancer patients with brain metastasis treated with Gamma Knife stereotactic radiosurgery. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2006.
7.
Kwok Y, M Won, WF Regine, M Mehta, F Schmitt, RA Patchell, and D Watkins-Bruner. Neurocognitive Impact of Whole Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR-0018. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, Ca, October 2007.
8.
Kwok Y, M Won, WF Regine, M Mehta, F Schmitt, RA Patchell, and D Watkins-Bruner. Neurocognitive Impact of Whole Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR-0018. Oral Presentation at Radiation Therapy and Oncology Group, San Diego, Ca, January 19, 2008.
9.
Kwok Y, Kataria R, Amin P, Naslund M, Hussain A, Dawson n, and Dibiase S. Long-term Results of a Prospective Phase II Trial of Androgen Ablation, Pelvic External Beam Radiation Therapy, Brachytherapy Boost, and Adjuvant Docetaxel in High-risk Prostate Cancer. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Boston, Ma, September 2008.
Invited Speeches 1. February 12, 2002 Contemporary Management of Supratentorial High-Grade Gliomas. Grand Rounds. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. 2. November 5, 2003 Introduction to Radiation Oncology. Lecture. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. 3. December 10, 2003 Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Univ of Maryland Medical Center-CME Lecture. Baltimore, MD. 4. January 21, 2004 Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Univ of Maryland Medical Center-CME Lecture. Bethesda, MD. 5. March 9, 2004 Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Univ of Maryland Medical Center-CME Lecture. Annapolis, MD. 6. June 15, 2004 Contemporary Management of Central Nervous and Head and Neck Tumors. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. 7. June 19, 2004 Diagnosis and Treatment of Trigeminal Neuralgia. Greater Baltimore Medical Center, Baltimore, MD. 8. June 19, 2004 Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Greater Baltimore Medical Center, Baltimore, MD. 9. October 15, 2004 Diagnosis and Treatment of Trigeminal Neuralgia. Cambridge Dental Group, Cambridge, MD. 10. October 15, 2004 Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Cambridge Dental Group, Cambridge, MD. 11. November 15, 2004 Diagnosis and Treatment of Trigeminal Neuralgia. Holy Cross Hospital, Silver Spring, MD. 12. November 15, 2004 Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Holy Cross Hospital, Silver Spring, MD. 13. May 26, 2005 The Role of Radiotherapy in Genito-urinary Malignancies. Grand Rounds. Division of Urology, Univ of Maryland Medical Center, Baltimore, MD. 14. July 7, 2005 Introduction to Radiation Oncology. National Youth Leadership Forum. University of Maryland Medical Center, Baltimore, MD 15. November 12, 2005 Lymphoma Review. Annual Mid-Atlantic ASTRO Review. University of Maryland Medical Center, Baltimore, MD 16. December 3, 2005 Management of Brain Metastasis from Lung Cancer. Annual Thoracic Malignancy Update, Cambridge, MD 17. October 12, 2006 Management of Spinal Cord Compression. European Society of Therapeutic Radiology and Oncology, Leipzig, Germany 18. December 7, 2006 CNS Review. Annual Mid-Atlantic ASTRO Review. University of Maryland Medical Center, Baltimore, MD 19. December 15, 2006 Stage I and II Seminoma. Solid-Tumor Board. University of Maryland Medical Center, Baltimore, MD 20. March 23, 2007 Prostate Cancer: Treatment Overview. Solid-Tumor Board. University of Maryland Medical Center, Baltimore, MD 21. April 13, 2007 Prostate Cancer: Determinants of Outcome. Solid-Tumor Board. University of Maryland Medical Center, Baltimore, MD 22. June 2, 2007 Whole Brain Radiation Therapy in the Management of Brain Metastasis from Non-small Cell Lung Cancer. American Society of Clinical Oncology, Chicago, Il 23. October 25, 2007 CNS Malignancies. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD.
24. 25. 26. 27. 28. 29. 30. 31. 32.
December 13, 2007 Prostate Cancer: Treatment Overview. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD January 10, 2008 Genito-urinary Review. Annual Mid-Atlantic ASTRO Review. University of Maryland Medical Center, Baltimore, MD March 6, 2008 Chemoradiation in Locally-Advanced Cervical Cancer. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD March 26, 2008 Recent Technological Advances in Radiation Oncology. FDA: Center for Devices and Radiological Health—The Federal Research Center @ White Oak, Silver Springs, MD October 6, 2008 Contemporary Management of Non-metastatic Prostate Cancer. Grand Rounds. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD October 23, 2008 Contemporary Management of Non-metastatic Prostate Cancer. Grand Rounds. Division of Urology, Univ of Maryland Medical Center, Baltimore, MD October 27, 2008 Contemporary Management of Glioblastoma. GPIL 665 course— Special Topics in Cancer Biology, Fall 2008. Univ of Maryland School of Medicine, Baltimore, MD January 8, 2009 CNS Review. Annual Mid-Atlantic ASTRO Review. University of Maryland Medical Center, Baltimore, MD February 27, 2009 Introduction to Radiation Oncology. University of Maryland Radiation Oncology Interest Group. Univ of Maryland School of Medicine, Baltimore, MD
References William Regine, MD Chairman—Dept of Radiation Oncology University of Maryland Medical System Office: 410-328-2326 Pager: 888-491-1751 Mobile: 410-916-2350 Email: wregine@umm.edu Mohan Suntharalingam, MD Administrative Director—Cancer Center Vice Chairman—Dept of Radiation Oncology University of Maryland Medical System Office: 410-328-2331 Pager: 888-350-1982 Mobile: 410-598-7245 Email: msuntha@umm.edu Carl Mansfield, MD, SCD, FACR, FACNM Retired Chairman—Dept of Radiation Oncology University of Maryland Medical System Office: 215-592-8063