Scientific Highlights
Issue 4/21
Transl Res. 2021 May 13;S1931-5244(21)00119-5. doi: 10.1016/j.trsl.2021.05.001.
Diabetic wound healing in soft and hard oral tissues K I Ko, A Sculean, D T Graves
Abstract There is significant interest in understanding the cellular mechanisms responsible for expedited healing response in various oral tissues and how they are impacted by systemic diseases. Depending upon the types of oral tissue, wound healing may
occur by predominantly re-eptihelialization, by re-epithelialization with substantial new connective tissue formation, or by a a
combination of both plus new bone formation. As a result, the cells involved differ and are impacted by systemic diaseses in various ways.
Diabetes mellitus is a prevalent metabolic disorder that impairs barrier function and healing responses throughout the human body. In the oral cavity, diabetes is a known risk factor for exacerbated periodontal disease and delayed wound healing, which
includes both soft and hard tissue components. Here, we review the mechanisms of diabetic oral wound healing, particularly on impaired keratinocyte proliferation and migration, altered level of inflammation, and reduced formation of new connective tissue and bone.
In particular, diabetes inhibits the expression of mitogenic growth factors whereas that of pro-inflammatory cytokines is
elevated through epigenetic mechanisms. Moreover, hyperglycemia and oxidative stress induced by diabetes prevents the
expansion of mesengenic cells that are involved in both soft and hard tissue oral wounds. A better understanding of how
diabetes influences the healing processes is crucial for the prevention and treatment of diabetes-associated oral complications. Adapted from K I Ko et al., Transl Res. 2021 May 13;S1931-5244(21)00119-5., for more info about this publication click HERE
H Francisco et al., Clin Oral Investig. 2021 May 5| K K Changi, et al., Clin Oral Implants Res. 2019 Apr;30(4):306-314| R Al Jasser et al., Sci Rep. 2021 May 4;11(1):9526 | A Friedmann.et al., Clin Oral Investig. 2021 May 3| B P Jonker et al., Clin Oral Implants Res. 2021 Jun 15| S Kappel et al., Clin Oral Implants Res. 2021 Jun 24 | W Derksen et al., Clin Oral Implants Res. 2021 Jun 3 | L Gremillard, Materials (Basel). 2021 Jun 5;14(11):3103| F Bornert et al., Clin Exp Dent Res. 2021 May 5| S Alshali et al., J Oral Implantol. 2021 Jun 5| M Fonseca et al, Clin Oral Implants Res. 2021 Jul;32(7):853862| A Solderer et al, J Oral Sci. 2021 Mar 31;63(2):152-156| A Alberti et al, Materials (Basel). 2021 Jun 3;14(11):3045 | S Gupta et al, J Biol Regul Homeost Agents. Mar-Apr 2021;35(2 Suppl. 1):5365| K I Ko et al., Transl Res. 2021 May 13;S1931-5244(21)00119-5| source: www.pubmed.gov| Dr Nair holds a position of Global Scientific Communications Manager at Institute Straumann in Basel, Switzerland.
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