NANO DISPERSER Nano Disperser that is high pressure homogenizer make a smaller particle to nano size by only high pressure. It make higher quality than traditional method such as homomixer, ultrasonic, ball mill, etc. Drug Particles (Drug - Folic acid)
Drug & Cosmetics (Emulsion, Micelle – Coenzyme Q10 100 bar, 5 Pass
600 bar, 5 Pass
900 bar, 5 Pass
1000 bar, 30 Pass
Increase of Pressure
10
Volume(%)
8
Droplet Deformation
6 4
Reduction of Particle Size Uniform Particle Size
2 0
0.01
0.1
1
10
100
1000
3000
Disruption Particle Size(㎛)
Ref. Proceed. Int'l. Symp. Control. Rel. Bioact. Mater. 27 (2000) 8141-8142
Ref. Int. J. Pharm. 420 (2011) 93-100.
Food (Milk Droplet )
Cell Disruption (Yeast of Baker)
Depolymerization of Nature Polymer (Chitosan)
Shear Force
Entalglement and stretch
180
0 Pass 5 Pass
1000 bar
Viscosity(cP)
9
1500 bar
120 90 60
6
Cell Disruption by High Energy as shear, cavitation and impact
Reduction of Droplet Size
3
30
Uniform Particle Size
0
10
100
1000
Particle Size (nm)
SHEAR FORCE
1500 bar 208
200 150 100
102
50
50 30
0 0
1
2
3
4
5
6
0
The Number of Passes
0
Depolymerization
250
500 bar
150
12
Intensity(%)
Smaller Fragment
Molecular weight(kDa)
15
Cavitation & Impact
1
2
3
4
5
6
The Number of Passes
Ref. Electronic Journal of Polish Agricultural Universites. 10(2) (2007) #3.
FLOW TYPE
CAVITATION Z TYPE
Y TYPE
Inlet
IMPACT Shear Zone
Impact Zone Inlet
Outlet
Shear Zone
Impact Zone
Outlet
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