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PYRAZINAMIDE TABLETS 500 MG Package leaflet: Information for the patient Pyrazinamide 500mg Tablets. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. - Keep this leaflet. You may need to read it again. - If you have any further questions, ask your doctor or pharmacist. - This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. - If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor. What is in this leaflet 1. What Pyrazinamide is and what it is used for 2. Before you are given Pyrazinamide 3. How you will be given Pyrazinamide 4. Possible side effects 5. How Pyrazinamide is stored 6. Further Information
1. What Pyrazinamide is and what it is used for Pyrazinamide Tablets 500mg contain Pyrazinamide, which is an antituberculous
agent. Pyrazinamide Tablets 500mg are used for treating tuberculosis, commonly called ‘TB’. These products work by killing a particular type of bacteria which causes tuberculosis. Pyrazinamide Tablets are always given in combination with other antituberculous agents.
2. Before you are given Pyrazinamide Do not take Pyrazinamide Tablets 500mg if you: • are allergic (hypersensitive) to Pyrazinamide or any of the other ingredients of Pyrazinamide Tablets 500mg (see section 6 – Further information for details) • are breast-feeding • have liver disease • have gouty arthritis (arthritis associated with inflammation of the joints) • have an abnormally high concentration of uric acid in your blood • have a condition that results in a high level of porphyrin in your urine and extreme sensitivity to light. Take special care with Pyrazinamide Tablets 500mg if you: • are or think you may be pregnant • have kidney problems • have a history of gout (inflammation of the joints) • have diabetes • suffer from lactose intolerance • have received the oral typhoid vaccination, since Pyrazinamide may stop it from working, Pyrazinamide should be avoided 3 days before and after the vaccination • are taking oral contraceptives (the pill), since Pyrazinamide tablets may stop the pill from working. Use extra barrier
contraception methods (e.g. condoms) whilst you are taking Pyrazinamide tablets and for one month afterwards. Surgery and tests While taking Pyrazinamide Tablets you will be closely monitored. Your doctor or healthcare professional will probably take regular blood samples from you before and whilst taking Pyrazinamide Tablets. Your blood will be tested to make sure that your liver is working properly and that the levels of uric acid, a chemical usually found in urine and blood, do not increase. If the results of the blood test are abnormal, your doctor will ask you to stop taking your medicine. If you develop the following persistent symptoms: feeling sick, being sick, lacking in energy or a yellowing of the skin or eyes, stop taking Pyrazinamide tablets and contact your doctor immediately, as these may be signs of liver disease. Using other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Take care if you are taking the following medicines: • probenecid or sulfinpyrazone for gout. Your doctor will also prescribe other antituberculosis medicines for you to take with Pyrazinamide Tablets. Pregnancy and breast-feeding Pyrazinamide tablets should be used with caution during pregnancy. Do not use Pyrazinamide tablets if you are breast-
Pyrazinamide tablets 500 mg , Taj Phar ma : U ses, Side E ffe cts, Intera ctions , Picture s, Warni ngs, Pyrazina mide D osage & Rx I nfo | Pyrazina mide Use s, Side Effe cts – Antifungal/ Antiba cterial, Pyrazinami de tablets 50 0mg : I ndicati ons, Side E ffects, Warnings, Pyrazinami de - Drug I nformation - Taj P harma, Pyrazinamide
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feeding. Ask your doctor or pharmacist for advice before taking any medicine. Important information about the ingredients of Pyrazinamide Tablets This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
3. How you will be given Pyrazinamide Always take Pyrazinamide Tablets 500mg exactly as your doctor has told you to. You should check with your doctor or pharmacist if you are not sure. Adults and the elderly The usual dose is 3 tablets or 1.5 mg daily if you weigh under 50kg and your doctor is not supervising your medication on a daily basis. If you weigh more than 50kg, this may be increased to 4 tablets or 2g daily. If your doctor is supervising your medication on a daily basis, the dose for adults under 50kg is a maximum of 4 tablets or 2g 3 times a week. If you weigh over 50kg, the dose is a maximum of 5 tablets or 2.5g 3 times a week. The number of tablets you take each day will depend on your kidney function and your bodyweight. Children Pyrazinamide Tablets 500mg are supplied according to the weight of your child. If the medication is not supervised on a daily basis, the dose is 35mg/kg daily. If the medication is supervised on a daily basis, the dose is 50mg/kg 3 times a week.
If you take more Pyrazinamide Tablets 500mg than you should If you take more Pyrazinamide Tablets 500mg than you should, tell your doctor or go to the nearest hospital casualty department immediately. If you forget to take Pyrazinamide Tablets 500mg If you forget to take a dose at the right time, take it as soon as you remember then go on as before. Do not take a double dose to make up for a forgotten tablet. If you stop taking Pyrazinamide Tablets 500mg Do not stop taking the tablets without discussing it with your doctor. If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible Side Effects Like all medicines, Pyrazinamide Tablets 500mg can cause side-effects, although not everybody gets them. A rare side-effect is sudden liver failure which can be fatal. The most common side-effect is a liver reaction, which may occur at any time during therapy with Pyrazinamide Tablets. Symptoms of a liver reaction may include: • abnormal blood test results • fever • loss of appetite • feeling unwell • tender liver • enlarged liver • enlarged spleen • yellowing of the skin or eyes (jaundice).
Uncommon side-effects of Pyrazinamide Tablets include: • gout • anaemia – the symptoms of which are tiredness, general weakness and paleness of the skin • pain in the joints • loss of appetite • feeling sick • being sick • flushing (redness of the face) • difficulty in, or pain when passing urine • feeling unwell • fever • itching • raised red patches on the skin • skin reactions caused by sunlight e.g. rash • worsening of an ulcer in the stomach/intestines. If any of the side-effects get serious or if you notice any side-effects not listed in this leaflet, please tell your doctor or pharmacist. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. By reporting side effects you can help provide more information on the safety of this medicine.
5. How Pyrazinamide is stored Keep out of the sight and reach of children. Do not use Pyrazinamide Tablets 500mg after the expiry date which is stated on the blister and carton after EXP. The expiry date refers to the last day of that month. Store below 25°C.
Pyrazinamide tablets 500 mg , Taj Phar ma : U ses, Side E ffe cts, Intera ctions , Picture s, Warni ngs, Pyrazina mide D osage & Rx I nfo | Pyrazina mide Use s, Side Effe cts – Antifungal/ Antiba cterial, Pyrazinami de tablets 50 0mg : I ndicati ons, Side E ffects, Warnings, Pyrazinami de - Drug I nformation - Taj P harma, Pyrazinamide
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Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.
6. Further information What Pyrazinamide contains The active substance in Pyrazinamide Tablets 500mg is Pyrazinamide The other ingredients are lactose, maize starch, magnesium stearate, silicon dioxide and purified water
What Pyrazinamide looks like and contents of the pack Pyrazinamide Tablets 500mg are white, discoid, compressed, flat, bevelled tablets. They are supplied in bottles of 100 tablets or blister packs of 30 or 60 tablets. Not all packs sizes may be marketed.
Manufactured in India by: TAJ PHARMACEUTICALS LTD. Mumbai, India At: 615, GIDC, Kerala, Bavla, Dist. Ahmedabad 438225, Gujarat, INDIA This leaflet was last revised in July 2019