TRIENTINE HYDROCHLORIDE CAPSULES USP for Wilson’s Disease

TRIENTINE HYDROCHLORIDE CAPSULES USP for Wilson’s Disease – Taj Pharma • Trientine hydrochloride is a chelating compound for removal of excess copper from the body. • Its salt form, trientine (triethylenetetramine dihydrochloride or 2,2,2-tetramine) was introduced in 1969 as an alternative to D-penicillamine. Author: Mr. Pankaj Mahajan (M.Pharm)

Introduction: Taj Pharmaceuticals Limited manufactures and distributes medicines. The company’s products include prescription solutions, lifesaving drugs, anti-cancer drugs, veterinary products, consumer brands, and CNS drugs. It focuses on medicines of anemia, anxiety disorders, cancer/oncology, ear infections, heart failure, hepatitis, HIV/AIDS, influenza, non-Hodgkin’s lymphoma, obesity, osteoporosis, Parkinson’s disease, pneumonia, transplantation, and common diseases. Taj Pharmaceuticals Limited was founded in 2004 and is headquartered in Mumbai, India Taj Pharmaceuticals Ltd India | Taj Pharma | Taj Pharmaceuticals Mumbai, Company Overview of Taj Pharmaceuticals Limited |Taj Pharmaceuticals Limited Taj Pharmaceutical an Industrial conglomerate, having diversified interest in Pharmaceuticals and healthcare, Chemicals, API and Agro commodities mainly offers unique opportunities for all its associates to grow in capacity as one of a significant part in curing lives worldwide and building a disease-free nation. Taj Pharma is having more than 600+ brands in different divisions and multiple subsidiaries to meet up most of the requirements of buyers in our industry along with a very efficient staff management capacity.

Contents: Trientine hydrochloride capsules as specialty drug    

Drug Introduction / Company brief Intro Classification of Drug and Why / Specialty Drug Drug Delivery / Strengths / Finished Product Table Trientine hydrochloride finished product market a) Domestic b) Export  Therapeutic indication / mechanism of action / pharmacokinetics  Trientine hydrochloride active ingredient profile  Alternative Drugs Available (Lower version / advanced versions)  Trientine hydrochloride and role of Taj Pharma as Generics Manufacturer  Conclusion and future scope of research and advancement

Taj Pharmaceuticals Ltd India | Taj Pharma | Taj Pharmaceuticals Mumbai, Company Overview of Taj Pharmaceuticals Limited |Taj Pharmaceuticals Limited Taj Pharmaceutical an Industrial conglomerate, having diversified interest in Pharmaceuticals and healthcare, Chemicals, API and Agro commodities mainly offers unique opportunities for all its associates to grow in capacity as one of a significant part in curing lives worldwide and building a disease-free nation. Taj Pharma is having more than 600+ brands in different divisions and multiple subsidiaries to meet up most of the requirements of buyers in our industry along with a very efficient staff management capacity.

Classification Of Drug â&#x20AC;˘ Trientine Hydrochloride is a highly Selective Divalent Cu(II) Chelator and orphan drug that reverses copper overload in tissues. â&#x20AC;˘ It was previously approved by FDA in 1985 as secondline pharmacotherapy for Wilson's disease.

Source:- https://www.drugbank.ca/salts/DBSALT001269 Taj Pharmaceuticals Ltd India | Taj Pharma | Taj Pharmaceuticals Mumbai, Company Overview of Taj Pharmaceuticals Limited |Taj Pharmaceuticals Limited Taj Pharmaceutical an Industrial conglomerate, having diversified interest in Pharmaceuticals and healthcare, Chemicals, API and Agro commodities mainly offers unique opportunities for all its associates to grow in capacity as one of a significant part in curing lives worldwide and building a disease-free nation. Taj Pharma is having more than 600+ brands in different divisions and multiple subsidiaries to meet up most of the requirements of buyers in our industry along with a very efficient staff management capacity.

HOW WE SUPPLIED ? ď&#x192;&#x2DC; Available as : Generic name: Trientine 250mg Capsules, by TAJ. ď&#x192;&#x2DC; Supplied as : Capsules Trientine, 250 mg, are light brown opaque capsules. They are supplied as follows in bottles of 100.

PRODUCTS AVAILABLE IN MARKET

Sr.No

Name of the product

Quantity

Brand name

Manufacturer

TRIENTINE HYDROCHLORIDE CAPSULES USP

250 mg

SYPRINE

MERCK & CO. INC.

TRIENTINE HYDROCHLORIDE CAPSULES USP

300 mg

TRYPRINE

MEDICLONE

TAJ PRODUCTS AVAILABLE IN MARKET

Sr.No

Name of the product

Quantity

TRIENTINE HYDROCHLORIDE CAPSULES USP

250 mg

Brand name

Manufacturer

TAJ PHARMACEUTICALS

Market Packs

â&#x20AC;˘

Image Reference :-https://www.indiamart.com/proddetail/trientine-hydrochloride-capsules-300mgTaj Pharmaceuticals Ltd India | Taj Pharma | Taj Pharmaceuticals Mumbai, Company Overview of Taj Pharmaceuticals Limited |Taj Pharmaceuticals Limited Taj Pharmaceutical an Industrial tryprine-20398837697.html conglomerate, having diversified interest in Pharmaceuticals and healthcare, Chemicals, API and Agro commodities mainly offers unique opportunities for all its associates to grow in capacity as one of a significant part in curing worldwide and building a disease-free nation. Taj Pharma is having more than 600+ brands in different divisions and multiple subsidiaries to meet up most of the â&#x20AC;˘ liveshttps://www.gnhindia.com/products/trientine-dihydrochloride-trientine/ requirements of buyers in our industry along with a very efficient staff management capacity.

Product View

MECHANISM OF ACTION • Wilson’s disease (hepatolenticular degeneration) autosomal inherited metabolic defect resulting in an inability to maintain a near-zero balance of copper. • Excess copper accumulates possibly because the liver lacks the mechanism to excrete free copper into the bile. • This condition is treated with a low copper diet and the use of chelating agents that bind copper to facilitate its excretion from the body.

Reference:- https://mct.aacrjournals.org/content/early/2010/07/23/1535-7163.MCT-10-0523.full-text.pdf

Pharmacokinetics • Trientine is administered orally. • Both trientine and two metabolites, 1-N-acetyltriethylenetetramine (or acetyltrien) and 1-N-10-N-diacetyltriethylenetetramine, are excreted in the urine. • The bioavailability of trientine is approximately 6—18%; it is taken on an empty stomach in order to minimize the likelihood of inactivation by metal binding in the gastrointestinal tract. Food, milk, drugs, and mineral supplements could form a complex with trientine in the GI tract, which may prevent trientine absorption

Reference:- https://www.pdr.net/drug-summary/Syprine-trientine-hydrochloride-1386.826

Special Instructions

â&#x20AC;˘ It is important that trientine hydrochloride capsules be given on an empty stomach, at least one hour before meals or two hours after meals and at least one hour apart from any other drug, food, or milk. â&#x20AC;˘ The capsules should be swallowed whole with water and should not be opened or chewed.

Reference:- https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89970c97-2535-4856-b155 62d195b5147c#LINK_ca7560eb-38e6-4045-a8c2-6f2d9564bb5a

ADVERSE REACTIONS In Clinical Study :-

 Iron deficiency  Systemic lupus erythematosus

Marketed Product:  Dystonia  Muscular spasm  Myasthenia gravis.

Reference:- http://www.druginformation.com/RxDrugs/T/Trientine%20Hydrochloride%20Capsule.htm

Role of Taj Pharma as Generics Manufacturer • Taj Generics (Taj Pharma) provides a wide range of products to the Indian market, including an extensive range of generics and specialty products • Our products cover a vast array of therapeutic categories, and we offer an extensive range of dosage forms and delivery systems including oral solids, controlled-release, steriles, injectables, topicals, liquids, transdermals, semi-solids and high-potency products. • Our Generics portfolio offers over 1500 products in the major therapeutic areas of gastro-intestinal, cardiovascular, pain management, oncology, anti-infectives, paediatrics and dermatology.

Conclusion and future scope of research and advancement

Trientine Hydrochloride therapy has been shown to be an effective initial therapy, even with patients with decompensated liver disease at the outset, and prolonged treatment is not associated with adverse effects as expected in penicillamine treatment.