Cancer and Molecular Therapies

Prof. Rina

Rosin-Arbesfeld

Prof. Rosin-Arbesfeld received her PhD in Biochemistry and Microbiology from TAU and trained as a post-doctoral fellow at the MRC-LMB in Cambridge, UK. Rosin-Arbesfeld serves as Vice Dean for Preclinical Affairs and head of the Preclinical Promotions Committee of the Faculty of Medicine. Rosin-Arbesfeld has competitive grant funding from the US-Israel Binational Science Foundation, the Jerome Lejeune Foundation, and the German-Israeli Foundation for Scientific Research and Development.

Molecular changes in cancer

Wnt signaling is one of the most fundamental signaling cascades involved in both development and homeostasis. Aberrant activation of the Wnt pathway is associated with numerous diseases, most notably in the development of colorectal cancer (CRC). The RosinArbesfeld lab focuses on different aspects of Wnt signaling in both sickness and health. The team conducts comprehensive genetic and biochemical screens to isolate novel http://www3.tau.ac.il/rosin-arbesfeld/ regulators of the Wnt pathway in order to identify new targets for therapeutic purposes. Currently, the team is involved in pre-clinical, as well as clinical trials, aimed at restoring the normal expression of tumor suppressors, known to inhibit the Wnt pathway in patients suffering from hereditary CRC. The team is looking into the relationships between Wnt signaling and the microbiome and have identified bacteria that are involved in CRC development.

Wnts associate with the erythrocyte membrane