Development, Aging and Regeneration Dr. Daniel Bar

Molecular biology of aging

Aging is the major risk factor for many prevalent diseases in the developed world, including cancer, diabetes and cardiovascular disease. Systemically slowing the aging process has been shown to delay the onset of many diseases and prolong healthspan and lifespan in multiple model organisms. We now know of metabolic and pharmacological interventions that slow aging, and of epigenetic modifications that correlate with aging with https://barlabtau.wixsite.com/website exceptional accuracy. However, the molecular details of these interventions, as well as natural aging, are only partially known. The Bar lab develops new tools and applies them to study the molecular changes that accompany aging. These include using antibodies and various enzymes to label proteins, DNA and RNA and analyze them using highthroughput methods.

Dr. Bar is a principal investigator at the School of Dental Medicine. Dr. Bar earned his bachelor’s degree in physics and biology from Tel Aviv University. He later went on to complete his PhD in Genetics at the Hebrew University of Jerusalem in the lab of Prof. Gruenbaum. Here, Dr. Bar worked on the nuclear lamina and lifespan regulating pathways in C. elegans. He continued to a visiting-fellow position in the lab of Dr. Francis Collins at the National Human Genome Research Institute, the National Institutes of Health, USA. He worked on proximity labeling, focusing on the nuclear lamina in primary human samples. He serves as guest editor of JOVE.