Beef Cattle Production Series - Part 9 by TSCRA - The Cattleman Magazine

BEEF CATTLE PRODUCTION SERIES â&#x20AC;&#x201C; PART 9

Veterinary Feed Directive, Better Calving Season, Control Calf Crop Complications

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& CATTLE HEALTH Supplement to The Cattleman magazine.

“With Safe-Guard® I know it works. Every time.” Steve Howard - Stocker-backgrounder, Howard Ranches, Claypool, OK

NOSURPRISES As a stocker operator, Steve Howard is in a high-risk business. His cattle come from all over, and many of them have no known health history. So before he turns them out, he drenches them with Safe-Guard® (fenbendazole). It goes straight to the gut to kill worms and ensures his cattle get growing faster.

He keeps them gaining, growing and feeling good with Safe-Guard. Try Safe-Guard for two weeks. We are so confident that you will see a 90% reduction in parasitic infestation that if you don’t – the product is free.1 So what do you have to lose? Other than the parasites.

Text GAINS to 48109 to watch how Steve keeps his cattle growing. By texting in you agree to receive text messages from Merck Animal Health where you will receive offers and reminders. Up to six messages per month. You can opt-out any time by replying STOP to 48109. Text message and data rates may apply. 1 1992. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol. 44, 35–44. 2. 2006.The detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 136, 167–185

Consult your local veterinarian for assistance in the diagnosis, treatment and control of parasitism. merck-animal-health-usa.com • 800-521-5767 Copyright ©2018 Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. 2/18 BV-SG-57821-Howard US/SFG/0218/0005

CATTLE HEALTH

BEEF CATTLE PRODUCTION SERIES – PART 9

Veterinary Feed Directive, Better Calving Season, Control Calf Crop Complications Table of Contents 4 Veterinary Feed Directive — How’s It Working? 8 Keys to a Better Calving Season 10 Control Calf Crop Complications

The Cattleman, the monthly journal of Texas and Southwestern Cattle Raisers Association, is pleased to partner with Merck Animal Health on a series of seasonal beef cattle health management manuals. Thanks to the generous support of the Merck Animal Health technical services veterinarians, we are able to provide easy-to-read articles that educate and inform ranchers about various aspects of beef cattle health management. thecattlemanmagazine.com

Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9

Veterinary Feed Directive — How’s It Working? It’s been almost a year since the introduction of the veterinary feed directive and Guy Ellis, DVM, shares insight into how implementation is affecting cattlemen. By Nicole Lane Erceg

On Jan. 1, 2017, the cattle industry changed. After 2 years of preparation and discussions, the veterinary feed directive (VFD) rule officially went into effect. The directive regulates how antibiotics that are important to human health can be administered in livestock production. An effort to protect both animals and people, the directive essentially moved these antibiotics used in feed to a position “behind the counter,” allowing access only with a veterinarian prescription, solely for disease treatment and according to the product label. No manner of preparation can foresee all the industry challenges of any new regulation. Guy Ellis, DVM, and technical services veterinarian for Merck Animal Health, shares that VFD implementation has had its fair share of kinks as the industry adjusts to the new requirements. Overcoming challenges For a veterinarian to write a VFD or “prescription” for a

customer, a Veterinary Client Patient Relationship (VCPR) must be established with that producer and his or her animals. Every state has its own definition of what is required for a VCPR, but it generally requires that a veterinarian must make timely visits to the ranch and be able to responsibly make prescriptions for ranch animals in accordance with the law. “It’s just a matter of developing a relationship with the veterinarian so they can help you make responsible decisions for antibiotic use in your animals,” says Ellis. For large operations with a veterinarian on staff, the VFD is simply an added piece of paperwork sent to the feed mill. Owners of small herds must also have a veterinarian relationship, the VCPR, before an antibiotic is prescribed. Ellis says that confusion has occurred for some family ranches — which make up 98 percent of the ranches in Texas — around who has the VCPR on file and how many VCPRs might be necessary. For example, Ellis says he’s been asked these 2 questions

4 Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9 thecattlemanmagazine.com

but doesn’t have an answer yet: Does the wife need to be on the VCPR to pick up medicated feed? If a VCPR is established with the ranch owner, will the hired hand or another family member legally be allowed to administer the feed? Ellis believes that issues such as these will be worked out over time. Many ranchers already had a working relationship with a veterinarian prior to the official implementation of VFD and made an easy transition. For producers without a VCPR already established, Ellis says making it official is a simple process that requires a relationship and ranch visit so the vet can familiarize themselves with the operation. Then, when a VFD is needed, the vet can easily prepare it in digital or written form and send the file to the feed mill. He recommends that any rancher who does not already have a VCPR and who plans to use medicated feed, establish one immediately, before a situation occurs where animals need to be treated. Beyond restricting these important antibiotics, VFD halted the use of these antibiotics for performance — allowing administration only for disease treatment. Ellis doesn’t deny that implementation of the new rule has impacted production. The new law requiring the antibiotics to be fed according to the label has even sparked potential label changes, according to Ellis. He says there have been challenges because some drugs are not labeled for “free choice” consumption, requiring additional constraints on how the antibiotic could be fed at the ranch. “Cattlemen are very resilient and can adapt, recover and find new ways to make up for any performance issues,” says Ellis, noting that he isn’t familiar with any major issues associated with loss of performance. Being a part of the solution One development Ellis says is making the VFD process easier is the VFD digital format. He says this makes the process simple by allowing veterinarians to go online, write the prescription and share it with livestock producers and feed mills all from a computer. This format also makes file storage easy. The law requires that ranchers keep a copy of every VFD order for a minimum of 2 years. “I think the digital format has been the best thing that happened to make this process simple and easy to use,” says Ellis. Even with the minor challenges, Ellis says that the rule is functioning for the intended objective: helping the industry use antibiotics more responsibly. “Ultimately, the goal of the VFD was to reduce the amount of antibiotics used in production agriculture,” says Ellis. “I think it has created an atmosphere where if you are using antibiotics, you use them according to the way they were designed to be used and it has made us all more responsible in how we use antibiotics in food-producing animals.” thecattlemanmagazine.com

Establish a VCPR with your veterinarian Obtain a VFD for feed containing antibiotics medically important to human health Use VFD antibiotics only on animals as directed Keep a record of each VFD for two years

“We, as cattlemen and producers, can use this as an opportunity to build consumer confidence that we are going to do what we need to as a beef industry to ensure a safe and responsible food supply,” says Ellis. However, cattlemen can’t halt growing antibiotic resistance alone. Doing what is better for cattle and preventing resistance issues requires a mutual effort from veterinarians, ranchers and industry partners to continue to produce a profitable and healthy food supply. “When we do these things, working together as veterinarian and producer, I think it sends a great message to consumers that we are doing our part to judiciously use antibiotics and reduce what some believe are resistance factors associated with medically important antibiotics in human medicine.” ➤ Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9

We are going to have to be very responsible with the antibiotics we do have and very creative in finding alternate ways to be able to keep these cattle healthy without the use of antibiotics. What’s on the horizon? For a law that’s been in place less than a year, Ellis says the cattle industry has adapted well and made progress in meeting consumer needs, while balancing animal health. “The future is exciting, but the cattle industry is going to have to adapt, because we don’t have any new antibiotics on the horizon,” says Ellis. “We are going to have to be very responsible with the ones we do have and very creative in finding alternate ways to be able to keep these cattle healthy without the use of antibiotics. The Veterinary Feed Directive is going to continue to work and I think is going to get easier for everyone involved.”

For cattlemen looking for additional information and resources on VFD and antibiotic use in beef production, Ellis says a quick online search can result in an overwhelming amount of material. The resources he recommends cattlemen turn to include the FDA website, the Beef Cattle Institute at Kansas State University and North Dakota State University Extension. Members of Texas and Southwestern Cattle Raisers Association can find a series of articles on VFDs on the TSCRA resources page. This page is accessible by logging into your TSCRA membership at tscra.org. Navigate to TSCRA Resources and search for Veterinary Feed Directive. ❚

6 Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9 thecattlemanmagazine.com

We all need a little space every once in awhile, but your livestock should never be bothered by flies and other external parasites. When maintaining your livelihood, leave external parasite management to Merck Animal Health, a trusted name with a variety of solutions that fit your operation’s distinct premise, ear tag or pour-on needs.

See labels for complete instructions merck-animal-health-usa.com • 800-521-5767 Copyright © 2018 Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. 1/18 BV-56105

Keys to a Better Calving Season Timothy Parks, DVM, shares pre-calving preparation tips to make calving season easier. By Nicole Lane Erceg

Calving season is the time when success is crucial. To ensure a healthy calf crop and less stress during this season Timothy Parks, technical services veterinarian for Merck Animal Health, says a little planning and proper preparation are critical. Laying the groundwork for a smooth calving season begins long before the calf is born. Parks says it all starts with adequate nutrition. To be well prepared for calving, he recommends that ranchers make sure they are meeting energy demands for the third stage of gestation and any environmental challenges the cows may face. This, he says, is the foundational management tool. Calf scours prevention begins now One of the biggest threats to a successful calving season is neonatal calf diarrhea. Parks says this issue is one thatâ&#x20AC;&#x2122;s easy

to prepare for but it can be difficult to treat. The key to getting calves started well begins with colostrum. To provide the best protection for the calf, the cow should be producing high levels of antibodies when colostrum begins to be produced, about 6 weeks prior to calving. This requires planning for pre-calving vaccinations to hit this optimal window for ideal colostrum production. Parks advises ranchers to carefully read the labels on pre-calving vaccines because timing is vital to capturing the value of these products and protecting the calf. When selecting pre-calving vaccines, Parks recommends choosing a broad-spectrum product. For ranchers who have struggled with calf scours issues in the past, he says a diagnosis is vital to prevent the issue from re-occurring. Because products vary in formulation and protection levels of different antigens,

8 Merck Animal Health BEEF CATTLE PRODUCTION SERIES â&#x20AC;&#x201C; PART 9 thecattlemanmagazine.com

When selecting pre-calving vaccines, Parks recommends choosing a broad-spectrum product. understanding the cause of the calf scours problem will help the rancher select a vaccine that has the right formula to prevent it. “Pre-calving vaccines are a tool to help with neonatal calf diarrhea,” says Parks. “Management of the cow herd as well as weather conditions, climate and pasture conditions can also make or break a calving season.” As the calving season wears on, the challenge level for calves grows because the bacteria and contamination levels rise with the number of animals. Parks says that in most years, he sees the calf diarrhea issues rise during the second half of calving season. To avoid this spike in disease, he recommends scattering the cattle and moving cows to new, clean pastures to avoid the pathogens. “Scours is truly a management disease,” says Parks. “We have to make sure we are doing everything possible to reduce the amount of challenge that those animals come in contact with and allow our vaccines and the colostrum to get the calves through those crucial time frames.” In addition to building proper immunity through pre-calving vaccines and colostrum, pen and pasture management prior to calving season, and planning for open pastures to move cattle to after it begins, can help ranchers avoid the negative effects of calf scours. “Management is so critical when it comes to calf diarrhea,” says Parks. “It’s vital to make sure we set ourselves up for the best success we can. We have to address the environmental side of it, then we can address the animal side of things.” The mistake most calving season veterans make It doesn’t matter how many calving seasons ranchers have been through, Parks says he hears the same thing every year — calving started sooner than expected. Being caught unprepared can cause a variety of issues which is why he recommends preparations begin long before the first calf is expected to hit the ground. He also advises ranchers to begin checking cows and heifers about 2 weeks before the first anticipated calving date. “Make sure you are checking early and have the calving

areas ready ahead of time,” says Parks. “You don’t want to be caught unprepared.” Calving season must-haves In building a “calving kit” Parks says there are a few basics cattlemen should never leave home without. First on his list is colostrum. He recommends always having some form of supplemental colostrum on hand before calving season begins. Although mom’s milk is best, there are times where colostrum will need to be supplemented. Parks recommends keeping packaged colostrum on hand just in case. His other go-to supply to stock up on before calving starts is iodine. Although it might sound simple, Parks says many experienced cattlemen sometimes forget the power adding iodine on navels can have in preventing disease. “One important thing to remember is that the navel is a tube, so when we spray the outside of it, we might not be getting all the protection we want,” says Parks. “Get iodine right on the end, on the inside of the navel, to help seal over where pathogens will enter the animal.” His No. 1 tip? Have a good understanding with a veterinarian on the expectations for calving season. He says to discuss the plan for dealing with dystocia and exactly how long to wait before getting involved if a heifer or cow begins to struggle. “As a veterinarian, it’s always more enjoyable when we deliver a live, healthy calf,” says Parks. “Have a good understanding with your veterinarian so you know at what point to intervene and when to call for help.” Parks’ rule of thumb after seeing the first sign of a calf and no progression is waiting 45 minutes for a heifer and 2 hours for a cow before getting involved or calling for help. The to-do list can easily grow long in the weeks before calves are born, but putting the time in to prepare for the busy season pays off in a multitude of ways. “The end result of a live calf is what we’re all after,” says Parks. “Those are the ones that pay our bills and move us forward so we need to make sure we are getting that live, healthy calf.” ❚

Have a good understanding with a veterinarian on the expectations for calving season. thecattlemanmagazine.com

Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9

Control Calf Crop Complications Emphasis on pre-calving cow health helps reduce neonatal calf diarrhea problems. By Nicole Lane Erceg

Months of work lead up to the moment a calf finally hits the ground. After hours agonizing over mating choices, countless days of ranch work and late nights checking cows for signs of labor, at long last a new baby is born. The last thing any rancher wants to see in the first moments and days of this new calf’s hard-earned life is sign of disease or sickness. Unfortunately, many producers know that at least a portion of their calf crop is bound to battle neonatal calf diarrhea, better known as calf scours. Calf scours results from infections from a variety of pathogens including viruses like bovine viral diarrhea (BVD), rotavirus or coronavirus; bacteria like Escherichia coli, salmonella and Clostridium perfringens; or the parasite Cryptosporidium. Although calf scours is created by a nasty concoction of microorganisms, the recipe for successful prevention is quite simple. Dr. Timothy Parks, DVM, cattle technical services veterinarian for Merck Animal Health, recommends focusing on creating a healthy immune system for the cow to pass on immunity to the calf. Parks says the key to calf health and strong immunity is in the colostrum. Calves are born without the protective immunity of antibodies to common disease organisms within their environment, so they depend on the “first milk” to transfer lifesaving antibodies from the dam. While most beef cows produce adequate colostrum on their own, it doesn’t contain the correct antibodies needed to prevent calf scours. Protecting calves from these harmful pathogens can be accomplished through a combination of a good scours vaccination program within the cow herd and proper pre-calving cow health management. Building an immune system for two A healthy cow’s immune system begins with adequate nutrition. This is increasingly important in the last 50 days of gestation because 80 percent of fetal growth occurs during this time. Adequate energy and protein are vital to protecting the cow’s immune system and meeting the energy requirements of a growing fetus. “The whole key to a successful start for the calf is that the cow’s immune system is strong enough to mount an immune response so good colostrum can be formed,” says Parks. A strong immune system for the cow helps support a strong immune system for the calf and Parks says cow nutrition is the foundation. Without proper nutrition, other scours prevention practices may not be successful. Lack of vital nutrients like protein will lead to insufficient

immune response from the cow and lack of calf vigor upon birth. Producers should aim for cows to reach a body condition score (BCS) of 5 and heifers a BCS of 6 prior to calving. The overlooked organism Ensuring adequate nutrition requires managing the parasite loads cows may be carrying after coming in from summer pasture. Cows with parasite problems may have compromised immune systems and can’t adequately utilize the feedstuffs provided. Parks recommends concentrating on lowering the parasite load for pregnant cows. Often forgotten, parasites affect the immune response of the cow and can impair the level of antibodies the cow will pass through the colostrum to the calf. “We need to make sure we are addressing parasite loads,” Parks says. “It’s one thing we can easily manage and it really gives the cow a chance to better utilize the nutrition in front of her, have a better immune system response and produce antibodies that are going to create better colostrum for the calf.” If the cow is weighed down by a heavy parasite load, the immune system will focus on battling her infection instead of generating a high immune response to the pre-calving vaccine. This can put the calf at a higher risk of infection and negate some of the economic benefits of a pre-calving vaccine regimen. “We know parasites will cause a down regulation on the

10 Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9 thecattlemanmagazine.com

SHE CAN DO IT.

OR YOU CAN TRY.

SCOURS VACCINATION CAN MEAN THE DIFFERENCE BETWEEN A GOOD DAY OF WORK – AND A COLD, HARD ONE. That’s why more producers are choosing to protect their calves from scours by vaccinating the pregnant cow or heifer with Guardian®. According to the U.S. Department of Agriculture, scours has been attributed to 17.2 percent of annual nonpredatory calf loss in U.S. cattle operations annually.1 If scours has affected your calves in the past, you know the real price of getting them back on their feet – time, treatment cost and heartache. USDA. 2011. Cattle and Calves Nonpredator Death Loss in the United States, 2010. USDA–APHIS–VS.

Guardian provides broad-spectrum viral and clostridial protection against the leading contributors to scours.

FOR YOUR HERD — FOR THE FUTURE — CHOOSE GUARDIAN. For more information talk to your veterinarian or Merck Animal Health representative. Or, to learn more go to The-Best-Defense.com/Guardian.

side of the immune system that wants to produce antibodies against viral infections,” says Parks. He recommends using a product that will rapidly kill worms and will quickly alleviate the stresses placed on cows carrying a large number of parasites. Timing is key The next step to addressing newborn calf immunity to scours is a pre-calving vaccination program. By strategically vaccinating the pregnant dam, pre-calving vaccinations will stimulate the production of antibodies in the mother’s body, which will be passed through the mammary glands in the form of colostrum, creating a first line of immunity for the newborn calf. Pre-calving cow vaccinations can greatly increase the level of antibodies in the colostrum, but the antibodies will only be absorbed by the calf if it ingests the adequate amount of colostrum within the first 6 to 12 hours of life. For pre-calving vaccinations to be effective in transmitting immunity, the pregnant cow must receive the correct dose during the appropriate window of time. Parks emphasises that vaccination timing is imperative to provide maximum protection. “The goal behind pre-calving vaccines is timing the maternal antibodies that the calf is going to get to peak at the time of colostral genesis,” says Parks. The target is to hit the highest antibody levels possible at the time that colostrum production begins. By timing vaccinations so that the antibody levels of the cow climax at about 5 to 7 weeks prior to calving, she will be creating maximum immunity colostrum. “We want to stimulate immunity in that cow so that we reach the highest antibody levels we can when colostrum production starts,” says Parks. Products will vary on the levels of antibodies they stimulate and the time it may take for the cow to launch a solid immune response. Popular pre-calving vaccines on the market include ScourGuard®, Scour Bos™ and Guardian®. All of these vaccines include protection against rotavirus, coronavirus, K99 E.coli and Clostridium perfringens type C. Guardian® is the only option that includes immunity to C. perfringens type D. Most products will be given anywhere between 2 and 4 months prior to calving and heifers will receive a booster within 2 to 3 weeks of the original vaccine administration, depending on the product. Keeping in mind the goal of achieving the highest antibody levels at the time of colostral genesis, a peak response can take about 14 to 28 days. Vaccination timing and knowledge of the product is critical to achieving the highest antibody levels 5 to 7 weeks before calving. Parks recommends consulting a veterinarian to determine the best approach. “Consider which diseases are prevalent in your area,” Parks says. “What are those cows seeing the strongest challenge

from? Your veterinarian is going to be the best resource to find answers to these questions.” For cattlemen who have dealt with scours outbreaks in the past, proper diagnosis of the infection agent is critical to preventing future loss. Calf scours can be the result of a variety of bugs, but some have specific therapies available for prevention. Combined with quality management practices, a good vaccine program can significantly reduce or eliminate sickness and death loss due to calf scours. However, it takes more than pre-calving vaccinations to provide effective immunity to a newborn calf. Parks reminds ranchers that vaccinations will never replace poor management. Avoiding high mortality Due to the complex nature of the variety of pathogens that can cause calf scours, total prevention may not be a realistic expectation in some cases. However, calf mortality and morbidity can be greatly reduced through a combination of sound management practices and pre-calving vaccinations. “We may still see disease, but we hope we are setting this calf up so that if it does come in contact with disease, the disease is not as severe, it doesn’t last as long and the calf requires less treatment and can quickly return to a normal state,” says Parks. Calf mortality rises when calf scours is caused by a coinfection of multiple pathogens. While vaccines are available for some causes of calf scours, others like Cryptosporidium cannot be vaccinated against. Parks recommends vaccinating against agents for which that option is available, to avoid co-infections and better prepare a calf to deal with any infection scenario. “If we can give the calf a good start and it has a chance to get the antibodies against the neonatal calf diarrhea agents that we’ve vaccinated against, then when we have some of those co-infections, the calf mortality rate is much lower,” says Parks. Rapid weather changes and calving conditions can also affect the levels of infection. Wet, muddy conditions and high pasture stocking rates while calving can greatly attribute to the number of scours incidents. While some calving conditions like the number of cattle per pen or pasture can be addressed to reduce outbreak, adverse weather conditions are beyond a cattleman’s control. Parks recommends keeping calving areas clean, limiting cross-contamination between calving groups and vaccinating as a form of insurance for unforeseen calving stressors and scours outbreaks. “Anytime we can do something to prevent an infection, just to have that calf where it is ready to fight anything that might come its way, we are in much better shape,” says Parks. To successfully combat a disease as complex and costly as calf scours, it must be managed from multiple angles. By building strong immune systems in pregnant cows, producers create stronger calf crops ready to withstand pathogen pressures. ❚

12 Merck Animal Health BEEF CATTLE PRODUCTION SERIES – PART 9 thecattlemanmagazine.com

ONE DOSE. TWICE THE SECURITY. merck-animal-health-usa.com • 800-521-5767 Copyright © 2018 Intervet Inc., doing business as Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. 1/18 BV-Once-56398-B

Once PHM® IN protects your calves from Mannheimia haemolytica and Pasteurella multocida – two of the leading forms of bacteria that cause early-onset BRD – so you’re double covered. One intranasal dose, no needle, given as young as 1 week of age, is all it takes. Easy for you, easy on them. For more information, talk to your Merck Animal Health representative or visit The-Best-Defense.com/Once_PMH.

Knock out BRD and take down the fever that usually comes with it when you use Resflor Gold® (florfenicol and flunixin meglumine). The only major antibiotic to combine the BRD-treating action of florfenicol with the symptom-fighting action of flunixin. With one shot, Resflor Gold makes your animals feel better within six hours.1,2 So they aren’t just back on their feet eating and drinking, they’re back on the gaining track. Talk to your Merck Animal Health rep or visit resflorgold.com to learn more.

IMPORTANT SAFETY INFORMATION NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains material that can be irritating to skin and eyes. Animals intended for human consumption must not be slaughtered within 38 days of treatment. This product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal period has not been established in preruminating calves. Do not use in calves to be processed for veal. Do not use in animals that have shown hypersensitivity to florfenicol or flunixin. Not for use in animals intended for breeding purposes. The effects of florfenicol and flunixin on bovine reproductive performance, pregnancy, and lactation have not been determined. When administered according to the label directions, RESFLOR GOLD may induce a transient local reaction in the subcutaneous and underlying muscle tissue. Brief summary available on adjacent page. 1 2

Exhibits bactericidal activity against some strains of Mannheimia haemolytica and Histophilus somni. The correlation between in vitro susceptibility data and clinical effectiveness is unknown.

PRODUCT INFORMATION NADA 141-299, Approved by FDA.

(Florfenicol and Flunixin Meglumine) Antimicrobial/Non-Steroidal Anti-Inflammatory Drug For subcutaneous use in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal. (Florfenicol and Flunixin Meglumine) BRIEF SUMMARY: For full prescribing information, see Antimicrobial/Non-Steroidal Anti-Inflammatory Drug package insert. ® For subcutaneous use in GOLD beef and INDICATION: RESFLOR isnon-lactating indicated for dairy cattle only. respiratory Not for usedisease in female dairy treatment of bovine (BRD) associated cattle 20 months of age or older or in calves to with Mannheimia haemolytica, Pasteurella multocida, be processed for veal. Histophilus somni, and Mycoplasma bovis, and control of BRIEF SUMMARY: For full prescribing information, see BRD-associated pyrexia in beef and non-lactating dairy package insert. cattle.

INDICATION: RESFLOR Do GOLD is indicated CONTRAINDICATIONS: not use in animalsforthat treatment bovine respiratory to disease (BRD) associated have shownof hypersensitivity florfenicol or flunixin. ®

with Mannheimia haemolytica, Pasteurella multocida,

Histophilus somni, andFOR Mycoplasma bovis, andKEEP control OUT of WARNINGS: NOT HUMAN USE. in beef and dairy OFBRD-associated REACH OFpyrexia CHILDREN. Thisnon-lactating product contains cattle. that can be irritating to skin and eyes. Avoid material direct contact with skin, Do eyes, case CONTRAINDICATIONS: notand use clothing. in animalsInthat ofhave accidental eye exposure,toflush with or water for 15 shown hypersensitivity florfenicol flunixin. minutes. In case of accidental skin exposure, wash WARNINGS: NOT FOR HUMAN USE. KEEP OUT with soap and water. Remove contaminated clothing. OF REACH OF CHILDREN. This product contains Consult a physician if irritation persists. Accidental material that can be irritating to skin and eyes. Avoid injection of thiswith product may and cause local Inirritation. direct contact skin, eyes, clothing. case Consult a physician immediately. The Material of accidental eye exposure, flush with water for 15 Safety Data Sheet (MSDS) contains more detailed minutes. In case of accidental skin exposure, wash occupational safety with soap and water.information. Remove contaminated clothing. Consult a physician if irritation persists. Accidental

For customer or to may obtain a copy the MSDS, injection of service this product cause localof irritation. call 1-800-211-3573. For technical assistance or to report Consult a physician immediately. The Material suspected adverse reactions, call 1-800-219-9286. Safety Data Sheet (MSDS) contains more detailed occupational safety information.

Not for use in animals intended for breeding purposes. For customer or to obtain copy of the MSDS, The effects service of florfenicol on a bovine reproductive call 1-800-211-3573. For technical assistance or tonot report performance, pregnancy, and lactation have been suspected adverse reactions, call 1-800-219-9286. determined. Toxicity studies in dogs, rats, and mice have associated the use of florfenicol withpurposes. testicular Not for use in animals intended for breeding degeneration atrophy. NSAIDs are known to have The effects and of florfenicol on bovine reproductive potential effects on bothand parturition performance, pregnancy, lactation and have the not estrous been cycle. There may be studies a delayinindogs, the onset of estrus determined. Toxicity rats, and mice if have associated the use of florfenicol with testicular flunixin is administered during the prostaglandin phase degeneration and atrophy. NSAIDs are known to have of the estrous cycle. The effects of flunixin on imminent potential effects on both estrous parturition have not beenparturition evaluatedandin the a controlled cycle.NSAIDs There may a delay in thethe onset of estrus if study. are be known to have potential to delay flunixin is administered during the prostaglandin phase parturition through a tocolytic effect. of the estrous cycle. The effects of flunixin on imminent

parturitionGOLD have®not been administered evaluated in a as controlled RESFLOR , when directed, study. NSAIDs are knownreaction to have at thethe potential delay may induce a transient site oftoinjection parturition through a tocolytic effect. and underlying tissues that may result in trim loss of ® edible tissue at slaughter. RESFLOR GOLD , when administered as directed, may induce a transient reaction at the site of injection and underlying tissues that may result in trim loss of RESIDUE WARNINGS: Animals intended edible tissue at slaughter.

for human consumption must not be slaughtered within 38 days of treatment. RESIDUE Animals Do not use WARNINGS: in female dairy cattle intended 20 months consumption must notin be offoragehuman or older. Use of florfenicol this slaughtered within 38 days of treatment. class of cattle may cause milk residues. A Do not use in female dairy cattle 20 months withdrawal period has not been established of age or older. Use of florfenicol in this inclass pre-ruminating Doresidues. not useA in of cattle may calves. cause milk calves to beperiod processed forbeen veal.established withdrawal has not in pre-ruminating calves. Do not use in calves to be processed for veal.

ADVERSE REACTIONS: Transient inappetence, diarrhea, decreased water consumption, and injection ADVERSE Transient with inappetence, site swelling REACTIONS: have been associated the use of diarrhea, decreased and injectionand florfenicol in cattle.water In consumption, addition, anaphylaxis site swelling have been associated with the collapse have been reported post-approval use withofthe florfenicol in formulation cattle. In addition, anaphylaxis and use of another of florfenicol in cattle. collapse have been reported post-approval with the

of another formulation of florfenicol in cattle. reactions, Inuse cattle, rare instances of anaphylactic-like some of which have been fatal, have been reported, reactions, In cattle, rare instances of anaphylactic-like primarily following intravenous flunixin some of which have been fatal, haveuse been of reported, meglumine. primarily following intravenous use of flunixin meglumine.

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BEEF CATTLE PRODUCTION SERIES â&#x20AC;&#x201C; PART 9

Veterinary Feed Directive, Better Calving Season, Control Calf Crop Complications

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