6 minute read
Reproductive Science Center of NJ
With the ever-increasing awareness and use of in vitro fertilization (IVF) to achieve pregnancy, women may be surprised to learn that their embryos can be tested to check for problems that may affect their likelihood of a successful pregnancy and the future health of their offspring. Preimplantation genetic testing can be performed on high-quality embryos, and this technology can improve the selection of a genetically normal embryo that in turn has the possibility of reducing future genetic disease.
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What is preimplantation genetic testing (PGT)?
PGT is a laboratory technique where a few cells of an embryo are removed and tested, providing genetic information that is used to select the best embryo/embryos suitable for transfer. Patients undergo an IVF cycle, and embryos are then tested either for their chromosome number or for a specific genetic mutation.
What tests are done with PGT?
Embryos undergo genetic testing to check for either a specific disease, or are screened to look at the number of chromosomes present. The results tell whether an embryo carries a specific genetic mutation, or if it has a normal number of chromosomes. There are two techniques that correspond to each testing condition. This includes preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS).
What is preimplantation genetic diagnosis (PGD)?
For women with hereditary or familial cancers, one way to avoid the risk of potentially transmitting genetic mutations is to perform PGD. PGD involves testing for specific genetic mutations, such as the BRCA breast cancer gene, cystic fibrosis, and other single-gene disorders. PGD can dramatically decrease the chances of disease in patients undergoing IVF.
What is preimplantation genetic screening (PGS)?
PGS involves testing an embryo for chromosome abnormalities and chromosome number. This testing becomes more important in older women or in those with advanced ovarian aging following fertility testing. It does not test for specific genetic mutations or diseases as with PGD. Since many women and men will have eggs and sperm that are not chromosomally normal, use of PGS can help increase the pregnancy success following IVF and embryo transfer.
What is the success rate for PGT?
Although both PGD and PGS utilize the latest cutting-edge laboratory technologies and are helpful in selecting the best embryos for transfer into the uterus, the success and pregnancy rates are affected by many factors. This includes the age of the patient, presence of good ovarian reserve, and creation of fairly large numbers of high-quality embryos for testing. Your individual success rate should be discussed with your physician, and a tailored treatment plan will be constructed to give you the highest chance of pregnancy and delivery of a healthy child.
Should I have PGT done?
We welcome you to schedule an appointment in our office to speak with one of our physicians about whether PGT is right for you. At the Reproductive Science Center of New Jersey, we are available to answer your fertility questions, perform a complete fertility evaluation, and present you with individualized options for conception, all in a comfortable, caring setting. We are a fullservice fertility center experienced in all the latest technologies and look forward to helping you achieve success.
For more information call our Eatontown office number at 732-918-2500 or visit www.FertilityNJ.com.
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• Comprehensive Fertility Care • InVitro Fertilization (IVF) • Intrauterine Insemination • Intracytoplasmic Sperm Injection (ICSI) • Preimplantation Genetic Testing • Egg Freezing • Donor Egg • Treatment for Recurrent Pregnancy Loss • Advanced Robotic Reproductive Surgery
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Pictured (L-R): Dr. William F. Zeigler • Dr. Alan M. Martinez
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Eatontown • Toms River • Lawrenceville 732-918-2500 • FERTILITYNJ.COM
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graduated from Creighton University School of Dentistry in Omaha, NE in 1994. He completed his residency in Advanced Education in General Dentistry at Temple University in Philadelphia, PA in 1995. He is the alumni of the world famous Las Vegas Institute for Advanced Dental Studies and member of the International Association of Physiologic Aesthetics. He also lectures at Monmouth Medical Center.
Balaji Srinivasan, DDS
Creating relationships are the hallmark of Aesthetic Dental Creations office operations. Located in Jackson NJ our dental office offers dental services for both Monmouth and Ocean County NJ residents along with other surrounding towns and counties.
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