The Gazette -- November 16, 2010 by Tim Windsor

o ur 3 9 th ye ar

LEA D ER S & LE G E N D S

ARRA RE S EAR CH

Covering Homewood, East Baltimore, Peabody,

CEO of Life Technologies talks

JHU team aims to find out if

SAIS, APL and other campuses throughout the

about ‘Building a 21st-Century

diet and exercise affect

Baltimore-Washington area and abroad, since 1971.

Company,’ page 2

cardiovascular health, page 7

November 16, 2009

R E C O G N I T I O N

T R A N S F E R

Hats off to our best Blue Jays

Opening for business opens doors

Athletic Center lobby begins transformation into JHU sports museum

By Greg Rienzi

The Gazette

ohns Hopkins considers itself a world leader in knowledge creation. In the past two years, the university has done a good deal of business creation, too. Aris Melissaratos, senior adviser to the president for enterprise development at Johns Hopkins since February 2007, said In the last that from day one he’s been trying to two years, change the culture here and make the JHU has university more spawned 22 entrepreneurial. When he arrived, Melissaratos said, companies he encountered a faculty population that was somewhat adverse to self-promotion and the business side of technology creation. “Commercialization had almost become a dirty word, and the prevailing thought was let’s not do anything to rock the research boat,” said Melissaratos, former secretary of Maryland’s Department of Business and Economic Development. “What I’ve been preaching is let’s get back to our roots and our prime mission, which is knowledge for the world. In that sense, it’s OK to be a little mercenary. Let’s do whatever we can to get the technology out there so it can help the world, while we never forget our institutional foundation of research excellence.” The efforts have paid off. Johns Hopkins in fiscal year 2008 spawned a dozen startup companies, seven of them based in Maryland, that collectively raised $76 million. This fiscal year, Johns Hopkins has already formed 10 companies, several of them dealing with medical devices or therapeutics that help fight infectious diseases and cancer. The 22 companies founded in the past two years almost double the number in the preceding seven years, when the average was four companies started annually, with a high of six. Continued on page 3

Volume 39 No. 12

he accomplishments of Johns Hopkins’ studentathletes never looked so good. Recent visitors to Homewood’s Newton H. White Athletic Center would undoubtedly have noticed the attractive new displays in the building’s lobby that commemorate the 114 members of Johns Hopkins’ Athletic Hall of Fame and the university’s 35 NCAA postgraduate scholarship recipients. The elegant two-sided displays feature etched black Plexiglas plaques that appear to float on a clear Plexiglas sheet. The Hall of Fame plaques are engraved with images of a Johns Hopkins Blue Jay, the university seal, the name of the student-athlete and his or her sport(s), class and induction year. The predominantly blue displays also feature fabric banners with images of JHU athletes in action. The two 17-by-14-foot displays, which were installed late last month, were created by Marketechs Exhibit Design, based in York, Pa. Marketechs Continued on page 6

jay vanrensselaer / HOMEWOODPHOTO.JHU.EDU

T E C H

The newspaper of The Johns Hopkins University

A new display in the Newton H. White Athletic Center pays tribute to the 114 members to date of Johns Hopkins’ Athletic Hall of Fame.

R E S E A R C H

‘Scaffolding’ protein changes in heart strengthen link between Alzheimer’s, chronic heart failure B y D av i d M a r c h

Johns Hopkins Medicine

n international team of biochemists and cardiologists led by researchers at Johns Hopkins reports evidence from studies in animals and humans supporting a link between Alzheimer’s disease and chronic heart failure, two of the 10 leading causes of death in the United States.

In Brief

School of Education discussion series; book collecting; CTY deadline; ‘Gazette’ schedule

The U.S., Canadian and Italian scientists say that they have identified three changes in the chemical makeup of desmin—a key structural protein—in heart muscle cells in dogs. The changes led to the formation of debrislike protein clusters, or amyloidlike oligomers containing desmin, in heart muscle, similar to the amyloid plaques seen in the brain tissue of Alzheimer’s patients. The protein alterations, which were reversed by surgically repairing the heart, occurred at the onset of heart fail-

C A L E N D AR

Rep. Sarbanes on health care reform; blood drive; Peabody Opera Theatre; ‘Grantcraft’

ure. Further experiments found the same chemical modifications to desmin in the heart muscle of four people already diagnosed with the disease. Misshaped desmin proteins and amyloidlike debris had been reported in 2005 in mice genetically altered to develop chronic heart failure, providing the first biological link between the two chronic diseases. Studies since have also reported desmin Continued on page 4

10 Job Opportunities 10 Notices 11 Classifieds

2 THE GAZETTE • November 16, 2009

CEO of Life Technologies to give ‘Leaders & Legends’ talk B y A n d r e w B l u mb e r g

Inspiring People in the pharmaceutical and biotechnology industries, and in 2006 the Carey Business School Penn State College of Engineering presented him with its World-Class Engineer regory T. Lucier, chief execuAlumni Award. tive officer of Life Technol Under Lucier’s guidance, Invitrogen ogies and chairman of the developed a robust philanthropy program company’s board dedicated to science eduof directors, will cation and promoting scispeak on the topic of “Building entific literacy. In 2008, a 21st-Century Company” at the company formed the the Johns Hopkins Carey BusiInvitrogen Foundation ness School’s Leaders & Legends (now the Life Technololecture series at 7:30 a.m. on gies Foundation), focused Wednesday, Nov. 18, at the on promoting the critical Legg Mason Tower in Harbor role science plays in sociEast. ety. Lucier is a former chairman From 2000 to 2003, and CEO of Invitrogen Corp., Lucier was president and which in 2008 merged with CEO of General Electric Applied Biosystems to form Life Medical Systems InformaTechnologies. The company is tion Technologies. one of the largest providers of Lucier, who received his systems, biological reagents and Gregory Lucier bachelor’s degree in engirelated services, supplying life neering from Pennsylvascience technologies to scientists worldnia State University and his MBA from wide. Harvard Business School, serves on the During Lucier’s tenure at Invitrogen, the boards of directors of the Biotechnology company was recognized four years in a row Industry Organization and the Burnham by the Life Science Industry Awards, which Institute for Medical Research. He is also are given to leading life science suppliers. a distinguished lecturer at San Diego State Invitrogen’s Qubit platform, which in 2007 University. received the prestigious R&D 100 Award as The Leaders & Legends monthly breakfast one of the most technologically significant series, which features today’s most influenproducts of the year, was one of many comtial business and public policy leaders, is pany innovations recognized by the indusdesigned to engage business and community try. professionals in an examination of the most Lucier was named the North American compelling issues and challenges facing sociDrug Discovery Technologies CEO of the ety today. Year in 2009 by Frost & Sullivan, which Admission to the lecture, which also named Life Technologies the Company includes breakfast, is $35. To register and of the Year. PharmaVOICE magazine recfor more information, go to carey.jhu.edu/ ognized Lucier as one of 2007’s 100 Most leadersandlegends.

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riday, Nov. 30, is the fall deadline for families to enroll a bright second- to eighth-grade student in the annual Talent Search sponsored by Johns Hopkins’ Center for Talented Youth. Testing done through CTY lets families see a child’s math and verbal talents and also can qualify a child for CTY’s summer or online courses for academically talented young people. CTY’s local three-week lineup for summer 2010 includes day programs in Brooklandville and Sandy Spring, Md., for students completing grades two to six, and a residential program at Homewood for students completing grades seven to 10. Tuition remission is possible, depending on unit policies. For more information, call 410-735-6278, e-mail ctyinfo@jhu.edu or go to www.cty.jhu.edu.

he Leonard and Helen R. Stulman Program in Jewish Studies in the Krieger School is hosting several international scholars this week during its fifth annual Lavy Colloquium, which examines ideas related to Jewish civilization. This year’s topic is The Jewish Jesus, and the conference will take place Wednesday and Thursday, Nov. 18 and 19, in the Smokler Center for Jewish Life, Homewood campus.

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he School of Education will be hosting a panel discussion titled “What’s Next After No Child Left Behind?” in anticipation of next year’s reauthorization of the legislation. The program, which is the culminating event in the school’s 100th anniversary celebration, will be held at 6:30 p.m. on Monday, Dec. 7, in Shriver Hall Auditorium on the Homewood campus. This program is the first in a discussion series titled Shaping the Future that will address the most challenging issues in education. Panel members on Dec. 7 are Martha Kanter, undersecretary of education, U.S. Department of Education; Nancy Grasmick, Maryland state superintendent of schools; Andres Alonso, CEO of Baltimore City Public Schools; Joe Hairston, superintendent of Baltimore County Public Schools; Robert Slavin, director of the Center for Research and Reform in Education at Johns Hopkins; James McPartland, director of the Center for Social Organization of Schools at Johns Hopkins; and Mariale Hardiman, former Baltimore City public school principal and chair of the Department of Interdisciplinary Studies at the School of Education. RSVPs can be submitted online at www .education.jhu.edu/shaping-future.

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Presenters from different disciplines will discuss various images of Jesus in ancient, medieval and modern Judaism, and will focus on representations of Jesus in Jewish philosophy, literature, visual arts and culture. The scholars will come from institutions near and far, including the Institute for Christian and Jewish Studies in the Theology Department at Loyola University in Baltimore; Princeton University; the University of California, Berkeley; the Hebrew University and the Israel Museum, both in Jerusalem; Tel Aviv University; and the Ben Gurion University in Israel. Speakers from Johns Hopkins include Yitzhak Melamed, an assistant professor in the Department of Philosophy, and Neta Stahl, the organizer of the colloquium and an assistant professor of comparative and modern Hebrew literature in the Humanities Center. Melamed will discuss “Christ According to the Spirit: Spinoza, Jesus and the Infinite Intellect.” Stahl’s talk is titled “We Left Yeshu: On Three 20th-Century Hebrew Poets’ Longing for Jesus.” The event is open to the public, though an RSVP is requested by e-mailing motterb @jhu.edu.

Sweren Student Book Collecting Contest gets under way

he 2009–2010 Betty and Edgar Sweren Student Book Collecting Contest has begun. The contest, sponsored by the Friends of the Johns Hopkins University Libraries, is open to all undergraduate and graduate students enrolled at Johns Hopkins. Prizes will be awarded for the top three collections in the undergraduate and graduate divisions. First place receives $1,000; second place, $500; and honorable mention, $250. For the entry form and complete rules, go to www.library.jhu.edu/friends/programs/ bookcollectcontest.html.

Latest student flu count: 408 H1N1 cases universitywide

s of Nov. 9, the most recent date on which statistics were released, 408 full-time students universitywide had been diagnosed with probable cases of H1N1 flu. The greatest number was at Homewood, where 329 cases had been identified. East Baltimore reported 30 cases; Peabody, 35; and SAIS, 14.

No ‘Gazette’ next week because of Thanksgiving break

here will be no ‘Gazette’ next week because of the Thanksgiving break. Today’s calendar lists events scheduled through Nov. 30, the date of our next issue. The deadline for calendar and classified submissions for the Nov. 30 issue is noon on Wednesday, Nov. 18.

Contributing Writers Applied Physics Laboratory Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Stephanie Desmon, Audrey Huang, John Lazarou, David March, Katerina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort

The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date. Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 410343-3362 or gazellegrp@comcast.net.

November 16, 2009 • THE GAZETTE

Surprising drug library find: 1930s med slows tumor growth By Audrey Huang

Johns Hopkins Medicine

rugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease. The newest surprise discovered by researchers at the Johns Hopkins University School of Medicine is a gonorrhea medication that might help battle cancer. “Oftentimes we are surprised that a drug known to do something else has another hidden property,” said Jun Liu, a professor of pharmacology and molecular sciences at Johns Hopkins and author on the study published Oct. 1 in the Proceedings of the National Academy of Sciences. In this case, the surprise is a big one. The drug acriflavine, used in the 1930s for treating gonorrhea, has turned out to have the previously unknown ability to halt the growth of new blood vessels. Preliminary tests showed that mice engineered to develop cancer had no tumor growth if treated with daily injections of acriflavine. “As cancer cells rapidly divide, they con-

sume considerable amounts of oxygen,” said Gregg Semenza, the C. Michael Armstrong Professor of Pediatrics and director of the vascular program at the Johns Hopkins Institute for Cell Engineering. “To continue growing, a tumor must create new blood vessels to deliver oxygen to the tumor cells.” Acriflavine stops blood vessel growth by inhibiting the function of the protein hypoxia-inducible factor, or HIF-1, which was discovered by Semenza’s team in 1992. When HIF-1 senses that the surrounding environment is low in oxygen, it turns on genes necessary for building new vessels. Though essential for normal tissue growth and wound healing, HIF-1 is also turned on by cancers to obtain the oxygen they need to survive. Most important, in order for HIF-1 to work, two subunits must bind together like puzzle pieces. Most drugs are unable to prevent protein binding because the drug molecules can be much smaller than the proteins with which they interact. A medicine must hit just the right spot, a critical domain or pocket on the surface of one protein, to stop it from binding to another protein. Even though drugs that stop binding are uncommon, they

are such an effective means to stop protein function that Semenza decided to look for one that might block HIF-1. To do that, he turned to the Johns Hopkins Drug Library, a collection of FDA- and internationally approved compounds that was assembled by Liu. To visualize protein binding, scientists engineered a cell line so that when the HIF-1 subunits came together, they would cause the cell to light up like a firefly. They then tested each of the more than 3,000 drugs in the drug library in hopes of finding one that would turn out the light. Acriflavine did, and further studies confirmed that it was binding directly to HIF-1. “Mechanistically, this is the first drug of its kind,” Liu said. “It is acting in a way that is never seen for this family of proteins.” Liu said he hopes that acriflavine can one day be incorporated into chemotherapy cocktails, one drug among many that help fight cancer. Johns Hopkins is seeking even more new uses for old drugs. So far, drugs in the library have been screened for use against malaria, tuberculosis, HIV and the Ebola virus. In the future, Liu expects even more research-

ers to take advantage of the library, which is continuing to grow. “In the public domain, Hopkins has the largest drug library,” Liu said. “The more drugs you have, the more possibilities, the higher the chance you rediscover something that will help.” This study was funded by the Johns Hopkins Institute for Cell Engineering and the Foundation for Advanced Research in the Medical Sciences. Authors on the paper are Kang Ae Lee, now of Princeton University; and Huafeng Zhang, David Z. Qian, Sergio Rey, Liu and Semenza, all of Johns Hopkins.

Related Web sites Institute for Cell Engineering:

www.hopkins-ice.org/index.html

Gregg Semenza:

www.hopkins-ice.org/vascular/int/ semenza.html

‘PNAS’:

www.pnas.org

Less physical activity may not be factor in adolescent obesity rates B y N ata l i e W o o d - W r i g h t

School of Public Health

ecreased physical activity may have little to do with the recent spike in obesity rates among U.S. adolescents, according to researchers at the Johns Hopkins Bloomberg School of Public Health. Prompted by growing concern that the increase was due to decreased physical activity associated with increased TV viewing time and other sedentary behaviors, researchers examined the patterns and time trends in physical activity and sedentary behaviors among U.S. adolescents based on nationally representative data collected since 1991. The review found signs indicating that the physical activity among adolescents increased while TV viewing decreased in recent years. The results are

featured in the Oct. 30 online issue of Obesity Reviews. “Although only one-third of U.S. adolescents met the recommended levels of physical activity, there is no clear evidence they had become less active over the past decade while the prevalence of obesity continued to rise,” said Youfa Wang, senior author of the study and an associate professor with the Bloomberg School’s Center for Human Nutrition and the Department of International Health. “During the recent decade, U.S. adolescents had greater access to TV, but significantly fewer of them watched TV for three or more hours per day. In addition, daily physical education attendance rates improved along with the use of physical education class in engaging in physical activity. However, there are considerable differences in the patterns by age, sex and ethnicity.” Wang, along with co-authors Shiru Li, former visiting scholar with the Center for

Business In his role, Melissaratos supervises the university’s Technology Transfer Office, the intellectual property administration center that serves Johns Hopkins researchers and inventors as a licensing, patent and technology commercialization office. The move forward started when the Technology Transfer Office adopted the motto “Johns Hopkins is open for business” and began to reach out aggressively to the business community in new and innovative ways. Just before Melissaratos arrived, the office helped launch the Vine and Venture Series, a quarterly series of after-business-hours talks now held at the Rangos Building of the Science + Technology Park at Johns Hopkins in East Baltimore. The talks feature representatives of major companies who come to speak with faculty and staff on how to partner with those in the pharmaceutical, biotechnology and medical technology communities. In June, the Technology Transfer Office co-hosted an inaugural Johns Hopkins Medicine Entrepreneurial Speed-Dating event in an effort to connect Johns Hopkins inventor scientists with entrepreneurs experienced in starting businesses. Organizers felt that such an event could accelerate the formation of new life science companies. By all accounts the event was a tremendous success, and it will be held next year.

SONJA KINZER

Continued from page 1

Aris Melissaratos

Melissaratos and others highlighted the recent boon of startups at the annual meeting of the Johns Hopkins Alliance for Science and Technology Development, which Melissaratos now chairs. The Alliance, founded in 2004, is a 40-member committee charged with evaluating the commercial viability of selected research projects at the university. Members of the Alliance—venture capitalists and research and development executives from the pharmaceutical and biotechnology industries—evaluate marketing opportunities and provide assistance with the identification of financing to enable the commercialization of worthy discoveries.

Human Nutrition, and Margarita Treuth, adjunct associate professor with the Center for Human Nutrition and a professor with the University of Maryland East Shore, examined findings from the nationally representative Youth Risk Behavior Surveillance surveys from 1991 to 2007. The surveys included U.S. high school students in grades nine through 12 and provided information about their physical activities, including enrollment and participation in physical education in school and sedentary behaviors including screen time. Based on these surveys, researchers examined the patterns and time trends and compared the observed physical activity patterns with the national goals set in Healthy People 2010, a comprehensive agenda for improving the health of all Americans. They found that minority students were less likely to be physically active and more likely to engage in sedentary behaviors than white students. Girls

were less active than boys, and decreased physical activity was related to an increase in age. “The large gaps between the 2007 achievement and the 2010 targets indicate that the goals are unlikely to be achieved by 2010,” Wang said. “Our study suggests that more vigorous efforts are needed to help young Americans engage in adequate regular physical activity and reduce sedentary behaviors, which will help promote good health. In addition, these findings may suggest factors other than physical activity and sedentary behaviors, such as unhealthy eating, may play a more important role to help explain the recent increase in obesity.” The research was supported in part by research grants from the National Institute of Diabetes and Digestive and Kidney Diseases and the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

The Alliance last year partnered with the University of Maryland to greatly expand the annual fall conference, held last week on Johns Hopkins’ Mount Washington campus. The two-day event drew nearly 190 people and allowed Johns Hopkins faculty the opportunity to present their inventions in 30-minute blocks to an audience full of colleagues, venture capitalists, biotechnology investors and local business leaders. The meeting also featured updates on recent startups and a presentation by Barbara Slusher and Jeffrey Rothstein, faculty members in the School of Medicine’s Neurology Department, about the Brain Science Institute’s new NeuroTranslational Program. The program was created with the mission of identifying and creating new drug therapies for neurological disorders, based on JHU faculty research. Melissaratos said that much has been accomplished over the past two years to transport the benefits of Johns Hopkins discovery to the world. “In the past, we have been criticized in some quarters for not being commercial enough or getting good results, but we’re turning that around,” he said. “Universities like Stanford and MIT have a legacy of starting lots of companies. We’re catching up. Events like the Entrepreneurial Speed-Dating help get the word out that we are easy to do business with and have expertise in many areas.” Melissaratos said that his office has also been training faculty to make more effective business presentations. Under the direction of Helen Montag, corporate relations man-

ager, and with the volunteer help of Michael Rosen, senior vice president for new business development at Forest City Enterprises’ Science & Technology Group, a training program has helped more than 100 faculty and staff by coaching them on effective marketing pitches to attract potential investors. The results, he said, can be lucrative. Technology transfer revenues have grown steadily from $9 million in fiscal year 2006 to $12.2 million in 2008. And Melissaratos said that he expects this growth to continue. He credits the leadership of Wesley Blakeslee, Technology Transfer executive director; Glen Steinbach, administrative director; Keith Baker, portfolio director; and a “superb” staff of licensing professionals. What’s next? Melissaratos said that he wants to work more with interdisciplinary centers such as the Center for Biomedical Innovation and Design, the Institute for NanoBioTechnology, the Center for Computational Medicine, the Brain Sciences Institute and the Institute for Basic Biological Sciences. Since 2000, 86 percent of the startup companies have been in the fields of therapeutics, medical devices and diagnostics. Melissaratos said he would like to expand technology transfer in the areas of information technology, engineering and the physical sciences. The “open for business” sign, he said, should be on everyone’s door. G For more information on the Technology Transfer Office, go to its new Web site at www .techtransfer.jhu.edu.

4 THE GAZETTE • November 16, 2009

Back pain permanently sidelines soldiers at war, study finds Few evacuated from Iraq or Afghanistan ever return, regardless of treatment By Stephanie Desmon

Johns Hopkins Medicine

ilitary personnel evacuated out of Iraq and Afghanistan because of back pain are unlikely to return to the line of duty regardless of the treatment they receive, according to research led by a Johns Hopkins pain management specialist. In a study published Nov. 9 in the Archives of Internal Medicine, researchers found that just 13 percent of service members who left their units with back pain as their primary diagnosis eventually returned to duty in the field. Women, officers, those deployed in Afghanistan and those with previous back pain had better outcomes but only marginally. Aside from combat injuries sustained during battle, the returnto-duty rate for spinal pain and other musculoskeletal disorders is lower than for any other disease or noncombat injury category except for psychiatric illness, the researchers said.

“The whole mission of the medical corps for the military is to preserve unit strength, to keep people doing what they’re doing,” said study leader Steven P. Cohen, associate professor of anesthesiology at the Johns Hopkins School of Medicine and a colonel in the U.S. Army Reserve. “If you have only a 13 percent success rate, this is a failure. There’s a systemic problem.” Cohen and his team looked at data from 1,410 soldiers who were medically evacuated out of war zones complaining chiefly of back pain from 2004 through 2007. More than 95 percent of the service members were taken to the U.S. military’s treatment facility in Landstuhl, Germany. Researchers assessed how many were returned to their stationed units within two weeks and how many were sent to the United States unable to perform their duties. A previous study done by Cohen, who is also director of chronic pain research at Walter Reed Army Medical Center, showed that when soldiers with back pain were taken to a pain clinic in Iraq, all patients returned to their units. When they were sent to pain clinics in Germany or in Washington, D.C., fewer than 2 percent did. Both this previous study and the new research suggest that the farther away evacuees are treated, the less likely they are to return to their units. Cohen noted that it can be difficult H O P K I N S

for certain soldiers to return to their jobs, particularly those in physically demanding combat-related roles. “It’s the rule in war: People will have back pain because you have to go on these long road marches and carry heavy equipment, wear body armor,” he said. “The roads are not paved. Riding in these vehicles while wearing body armor, it hurts your back.” Cohen said that the reason why few military personnel return to their units after leaving with back pain may simply be a reflection of the outcomes for back pain in civilian life. “Back pain has notoriously low success rates for treatment,” he said. The biggest predictors of a poor outcome, he said, are psychosocial factors. People who are depressed or anxious, cope poorly with stress, are unhappy in their jobs or have psychological issues are more likely to remain disabled by back pain. Cohen said that those with back pain who remain in the country where they are deployed may be more motivated to stay on the job or are more satisfied with their role in the military. The military needs to find a way to get soldiers with back pain back to their units wherever possible, said Cohen, suggesting that could be accomplished if there were more pain management options in Iraq or Afghanistan, following the model used for

soldiers with symptoms of combat stress. When those symptoms are treated at mental health clinics on base, approximately 95 percent of service members returned to their units. When treated in a transitional unit in nearby Kuwait, the figure was around 50 percent. When sent to Germany, fewer than 10 percent returned. Other researchers on the study are Shruti G. Kapoor, a resident in the Department of Anesthesiology at the Johns Hopkins School of Medicine; Maj. Conner Nguyen, chief of Physical Medicine and Rehabilitation at Landstuhl Regional Medical Center in Germany; and Col. Leslie Foster and Maj. Anthony Plunkett, both of Walter Reed Medical Center. The research was funded in part by a congressional grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, Pa.; the U.S. Army; and the Army Regional Anesthesia & Pain Medicine Initiative, Washington, D.C.

Related Web site Steven P. Cohen:

www.hopkinsmedicine.org/ pain/blaustein_pain_center/ physicians/cohen.html

H I S T O R Y

Honoring Dr. Gilman By Ross Jones

Special to The Gazette

he last thing Johns Hopkins trustees wanted to do toward the end of 1910 was to offend the two daughters of their late, beloved first president, Daniel Coit Gilman. But they came close to doing just that. Gilman had died, at age 77, on Oct. 13, 1908. As one might expect, the trustees This is part of an occasional series of historical pieces by Ross Jones, vice president and secretary emeritus of the university. A 1953 graduate of Johns Hopkins, he returned in 1961 as assistant to president Milton S. Eisenhower and was a close aide to six of the university’s 13 presidents.

‘Scaffolding’ Continued from page 1 changes in failing animal hearts, but none detailed what the chemical changes were or how they might affect organ function. Researchers say that their latest analysis, presented Nov. 15 at the American Heart Association’s annual Scientific Sessions in Orlando, Fla., is believed to be the first to tie common underlying structural changes in desmin to malformations observed in the heart as it weakens, strains to pump blood and starts to fail. Their results are also believed to be the first to suggest that toxic, desminlike amyloids could form in response to stress placed on the heart. “Our study leads us to believe that desmin plays a key role in heart failure,” said lead study investigator Giulio Agnetti, a protein biochemist. “Now we have a chemical target to research further and help us investigate what could be the underlying biological cause of heart failure and if it is, like Alzheimer’s, an amyloid-related disease. “Just as significantly, our study raises the prospect of testing new treatment options for heart failure by moving beyond treating symptoms of the disease and getting

expressed their sorrow in public statements and formal resolutions. They also pledged to find a suitable way to honor Gilman’s remarkable service to Johns Hopkins, the community and the world of higher education. But nothing had happened by 1910. The Gilman sisters grew impatient. How and when were the trustees going to honor their father? Elizabeth, in particular, pressed the trustees for action. At the same time, she had another idea of how that might be accomplished. Here the story must go back to Sept. 30, 1897, when the Country School for Boys began instruction in rented quarters in what was then known by many as the Carroll Mansion, now Homewood Museum on the Johns Hopkins Homewood campus. The school was founded by a prominent Baltimore woman, Anne Galbraith Carey. As she planned for

the school, she had sought and benefited from advice and counsel from Gilman. When the property was conveyed to Johns Hopkins in 1902, the Country School continued its tenant arrangement with the university, remaining there until 1910, when it moved to its present site north of the university in Roland Park. The school’s trustees sought and received permission from the Gilman sisters to change the name to the Gilman Country School for Boys. (In 1951 it became Gilman School.) The Johns Hopkins trustees were embarrassed that they had not yet found a way to memorialize Gilman, but they were deeply opposed to the Country School using his name. In a letter to Elizabeth Gilman on Dec. 15, 1910, board chair R. Brent Keyser said that he and his fellow board members “do not agree with the propriety of the present

use of your father’s name in connection with the Country School.” He added later, “but we withdraw all objection.” He continued, “Will you please accept from all of us our regret we have not so far been able to do that which we consider a matter of duty and affection.” The correspondence is in the Ferdinand Hamburger Archives of the Eisenhower Library. Keyser then advised the president of the Country School’s board of trustees that “all objection had been removed.” The president of that board was none other than Joseph S. Ames, the distinguished Johns Hopkins physicist who later served as president of the university (1929–1935). The memorial to Gilman finally was created when the first major building at Homewood, known in the planning stages as “the academic building,” was completed, in 1915, and named Gilman Hall.

to the root of the matter, preventing these desmin amyloids from forming and impairing heart function from the start,” continued Agnetti, a postdoctoral research fellow at both the Johns Hopkins School of Medicine and its Heart and Vascular Institute, and the University of Bologna and its National Institute for Cardiovascular Research, in Italy. Symptoms of heart failure may include fatigue, shortness of breath and enlargement of the heart. The team’s latest investigation began with an analysis of proteins contained in heart tissue samples collected from a group of dogs whose hearts had been surgically altered to beat irregularly, become stressed and fail. Additional tissue samples were taken from a group of healthy controls. Researchers compared these samples, looking for structural and chemical changes in desmin, which is found in all heart muscle cells and is a key component of the intermediate filaments that make up the scaffolding, or muscle cell support structure. This is the same muscle structure, they say, that becomes disorganized in heart failure. The team’s analysis yielded at least three chemical differences in each desmin protein in response to heart failure. Further tests showed that phosphate molecules had attached at two spots within the protein’s structure. They also found accumulating

amyloidlike debris, containing desmin, in the damaged heart tissue. When researchers performed surgery restoring the dogs’ heart pumping function to normal, they found that phosphorylated sites mostly reverted to normal. The amyloidlike oligomers also began to disappear. Tissue samples from four people with heart failure showed similar desmin modifications. Senior study investigator Jennifer Van Eyk said that it is “not surprising” that these changes in the so-called “scaffolding” structure of the heart can produce toxic debris. “But what is most interesting about our findings is that we have shown that these chemical changes and debris are related to impaired heart function, which, ultimately, may explain how and why the heart can fail,” said Van Eyk, a Johns Hopkins professor and director of Hopkins’ NHLBI Proteomics Group and the Proteomics Center at Johns Hopkins Bayview Medical Center, where the protein analysis took place. Researchers next plan to analyze each of the desmin modifications to determine the subsequent biological impact of each chemical change. Agnetti points out that the team’s protein analysis was made possible only in the last 15 years, with the development of technologies for detailed chemical analysis,

such as mass spectrometry and gel electrophoresis. Previously, he said, scientists had focused mostly on genetic changes and their relationship to disease, as opposed to disease-causing alterations to proteins that occur after proteins are made. Some 5.7 million American men and women suffer from chronic heart failure, which caused an estimated 290,000 deaths in 2005. A majority of sufferers have high blood pressure, the leading risk factor for the disease. Funding support for this study was provided by the National Heart, Lung and Blood Institute and Compagnia San Paolo di Torino, in Italy. The Johns Hopkins NHLBI Proteomics Group is one of 10 centers funded as part of the United States’ seven-year program dedicated to the study of proteomics and understanding the functions of proteins in the development of cells, tissues and organisms, in both normal and disease processes. In addition to Agnetti and Van Eyk, Johns Hopkins researchers who took part in this study were Victoria Halperin-Kuhns, Yurong Guo, Simon Sheng, Zongming Fu, David Kass and Gordon Tomaselli. Also involved in the analysis were Francesco Nicolini and Tiziano Gherli, both of the University of Parma; and Carlo Guarnieri and Claudio Caldarera, both of the University of Bologna. G

November 16, 2009 • THE GAZETTE

Young athletes need dual screening tests for heart defects B y D av i d M a r c h

Johns Hopkins Medicine

o best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins. Sudden cardiac death due to heart rhythm disturbances is blamed for more than 3,000 deaths a year in young people, especially athletes who have inherited tendencies to develop overly enlarged and thickened hearts, says Theodore Abraham, an associate professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute. In some instances, top athletes have died from heart conditions while seemingly in peak physical form, which can hide warning signs and allow many cases to go undiagnosed. In a study presented Nov. 15 at the American Heart Association’s annual Scientific Sessions in Orlando, Fla., Abraham and colleagues analyzed data from 134 top Maryland high school athletes that they screened at the 2008 track and field state championships. The researchers were looking for life-threatening cardiac abnormalities, such as hypertrophic cardiomyopathies. Doctors took a medical history, took weight and blood pressure measurements and listened for unusual heartbeats or murmurs. They also conducted an echocardiogram—a cardiac ultrasound, or ECHO—to measure heart size and pumping function and to check for faulty heart valves, and an electrocardiogram, or EKG, to assess the heart’s electrical rhythms. None of the student athletes were found to have life-threatening heart defects, but abnormal findings were discovered in 36 athletes. Twenty-two of those abnormalities

were found by EKG alone, nine by ECHO alone, and five were picked up on both tests. Those students with abnormalities— who included 19 with high blood pressure, 29 with elevated blood pressure in need of future monitoring and five with low blood pressure readings—were referred for follow-up to their doctors. “If you are going to screen, it has to be comprehensive,” said Abraham, who spearheads the annual Heart Hype screening program run by Johns Hopkins and designed to serve as a national model for other leading academic medical centers. Some screening programs include just EKGs and not ECHOs. “An EKG does show you a lot,” he said, “but it doesn’t tell you the whole story. The advantage of a comprehensive screening is that it is holistic rather than being pinpoint.” For example, if a doctor was screening for prostate cancer, “he wouldn’t ignore a large tumor on your head,” Abraham said. Lead study investigator Aurelio Pinheiro, a postdoctoral research fellow at Johns Hopkins, says he wasn’t surprised that he and his colleagues didn’t find anyone with a life-threatening heart abnormality, since it is estimated that one in 500 Americans has undiagnosed hypertrophic cardiomyopathy and the Johns Hopkins team screened fewer than that. Still, he says, the screening program is not designed just to prevent deaths from sudden cardiac arrest but also to raise awareness of the risks to young athletes. Less pressing—but still serious—medical conditions also were found by the researchers, notably high blood pressure, which in teenagers, Pinheiro says, can lead to heart failure or kidney disease 10 or 15 years in the future if left untreated. He adds that two of the track stars examined were obese, a condition that can lead to other health risks if not taken care of.

During this year’s screening program, doctors found a serious undiagnosed valve disease in one athlete and, in another, a condition that could likely mean a heart transplant in the future. The students had no symptoms. In some nations, programs to screen teenage athletes and nonathletes for possible heart problems have been routine for years. In 2004, the International Olympic Committee recommended that all athletes be EKG-tested every two years for potential heart abnormalities, regardless of whether they have a history of cardiac trouble. The U.S. Olympic Committee offers voluntary cardiac screening. Other screening programs have used just EKG and not ECHO, which the study suggests will miss some heart problems. Some argue that doing expensive diagnostic tests such as the EKG and ECHO are not worth the costs since sudden cardiac death

in young people is relatively rare, and mass screenings are unlikely to turn up a large number of teens in immediate danger. Abraham disagrees. “What is the price for a single life?” he asked. “We’re counting the costs upfront; we’re not counting the savings on the downstream end. They’re still teenagers. They think and feel like they’re at the top of the world,” he said. “Athletes and other teens should let someone know how they are feeling, especially if they have had chest pains, shortness of breath with activity or have fainted. This could save their life.” Other Johns Hopkins researchers involved in the study are Daniel Bernard, Veronica L. Dimaano, Saman Nazarian, Richard George, Reid Thompson and Joel Brenner. Deepti Bhandare and Luis Afonso, both of Wayne State University in Detroit, were also involved.

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6 THE GAZETTE • November 16, 2009

Blue Jays Continued from page 1 also created the Academic All-American Wall located in the hallway off the main lobby. The displays are viewed as phase one of an effort to transform the building’s lobby into a museum space, according to Mike Renwick, the university’s associate director of athletics. “We wanted to honor those who came before us and highlight the great tradi-

N O V .

Calendar Continued from page 12 Kathryn Zoon, NIAID. W2030 SPH. EB Mon., Nov. 16, 4 p.m. David Bodian Seminar—“Implementing Models of the Primate Visual Cortex in Silicon” with Ralph Etienne-Cummings, WSE. Sponsored by the Krieger Mind/Brain Institute. 338 Krieger. HW

“The Diverse Family of Proton-Pumping Respiratory Oxidases,” a Biophysics seminar with Robert Gennis, University of Illinois, Urbana-Champaign. 111 Mergenthaler. HW

Mon., Nov. 16, 4 p.m.

“Too Much and Just Enough of a Good Thing: Trisomy 21 and Down Syndrome,” a Biological Chemistry seminar with Roger Reeves, SoM. 612 Physiology. EB

Tues.,

Nov.

17,

noon.

Tues., Nov. 17, 12:10 p.m. “Inju-

ries in the U.S. Army,” a Graduate Seminar in Injury Research and Policy with Michelle CanhamChervak, U.S. Army Center for Health Promotion and Preventive Medicine. Second in the four-part series Occupational Injury, Safety and Health. Co-sponsored by Health Policy and Management and the Education and Research Center for Occupational Safety and Health. 250 Hampton House. EB

Tues., Nov. 17, 3 p.m. “Climate Variability and Colorado River Basin Water Management,” a Geography and Environmental Engineering seminar with Jeffrey Jacobs, National Research Council. 234 Ames. HW

“Use of Complex Psychotropic Medica-

Wed., Nov. 18, noon.

tions Among Children in the Child Welfare System,” a Mental Health seminar with Susan DosReis, SoM. B14B Hampton House. EB “Regulation and Function of the AktTSC-mTOR Signaling Network,” a Pharmacology and Molecular Sciences seminar with Brendan Manning, Harvard School of Public Health. West Lecture Hall, WBSB. EB

Wed., Nov. 18, 4 p.m.

“Central Nervous System Infection of the Human Herpesvirus-6 and Mechanisms of Neuroinflammation Mediated by Engagement of the CD46 Virus Receptor,” a Biology thesis defense seminar with Karen Yao, NIH. 100 Mudd. HW

Thurs., Nov. 19, 10 a.m.

Thurs., Nov. 19, 10:45 a.m.

“Molecular Model of the Airway Surface Layer in Lungs,” a Chemical and Biomolecular Engineering seminar with Michael Rubinstein, University of North Carolina, Chapel Hill. 110 Maryland. HW “Type IV Pilus Structure Function Studies: The Role of the Vibrio cholerae Toxin Coregulated Pilus in Colonization,” a Molecular Microbiology and Immunology/Infectious Diseases seminar with Lisa Craig, Simon Fraser University, Canada. W1020 SPH. EB Thurs., Nov. 19, noon.

Thurs., Nov. 19, noon. “Endowments, Framing, Defaults and the Power of Zero: What Behavioral Economics Can Tell Us About Health Care Reform,” an Institute for Policy Studies brown-bag seminar with Douglas Hough, Carey Business School. 526 Wyman Park Bldg. HW

as the all-time winningest coach in their respective sport in school history

1 — National ranking earlier this season for the JHU women’s cross-country team, and the first JHU women’s team ever to be ranked No. 1 nationally

12 — NCAA Championship teams

3 — Career individual national championships won by senior swimmer John Thomas 5 — Consecutive Centennial Conference titles for the women’s soccer team 7 — Combined Centennial Conference titles for the men’s and women’s tennis teams since 2005. Prior to 2005, JHU had never won a CC title in tennis. 11 — Current JHU coaches who rank

The new displays in the Athletic Center’s lobby represent phase one of a plan to transform the space into a museum heralding the university’s many sports teams.

tion of Johns Hopkins athletics,” Renwick said. “Everyone knows we have a really deep lacrosse tradition, but those who walk through the lobby now can see that we have a broad-based athletic program with excellence in many sports.” In phase two of the project, to be completed next summer, all of the existing wall display cases will be refurbished and seven new cases fashioned to prominently feature all the varsity sports. The cases will include photos, trophies, ribbons, historical facts and other elements. A centerpiece “champions case” will be created to highlight Johns Hopkins’ current conference

JHU athletics by the numbers

championship and national championship winners. The existing Hall of Fame room will be renovated in the final phase of the project. It will become a student-athlete lounge. “We’re going to spruce the room up and give it a more athletic feel,” Renwick said. The Johns Hopkins Athletic Hall of Fame was formed in 1994, and up to nine new members are inducted each year. The prestigious NCAA Postgraduate Scholarship was created in 1964 to promote and encourage postgraduate education by rewarding the National Collegiate Athletic Association’s most accomplished student1 6

–

Thurs., Nov. 19, 12:15 p.m.

“Genetic Conflict: The Usual Suspects and Beyond,” a Carnegie Institution Embryology seminar with Harmit Malik, Fred Hutchinson Cancer Research Center. Rose Auditorium, 3520 San Martin Drive. HW “What Do Astrocytes Do?” a Neuroscience research seminar with Ben Barres, Stanford University School of Medicine. West Lecture Hall, WBSB. EB

Thurs., Nov. 19, 1 p.m.

Thurs., Nov. 19, 4 p.m. “Quantitative Nanoscale Imaging of Biological Structures in the Electron Microscope,” a Biology seminar with Richard Leapman, NIBIB/ NIH. 100 Mudd. HW

“Vertical Farming and Public Health,” an Environmental Health Sciences Student Organization special seminar with Dickson Despommier, Columbia University, and director of the Vertical Farm Project. Co-sponsored by the Center for a Livable Future. W4030 SPH. EB

Fri., Nov. 20, noon.

“Beyond Social Capital: Routine Organizations and the Origins of Network Inequality of Everyday Life,” a Sociology seminar with Mario Small, University of Chicago. 526 Mergenthaler. HW

Mon., Nov. 23, noon.

“Molecular Mechanisms of Retinal Cell Fate Specification: The Role of Unconventional Transcriptional Regulators,” a Biological Chemistry seminar with Seth Blackshaw, SoM. 612 Physiology. EB

Tues., Nov. 24, noon.

Nov.

24,

12:10

16 — Consecutive post-season appearances for the men’s soccer team 21 — Academic All-America baseball players in JHU history, second all-time among all Division III baseball teams 35 — NCAA Postgraduate Scholarship recipients 38 — Consecutive NCAA Tournament appearances by the men’s lacrosse team 71 — Academic All-Americans

athletes. The NCAA awards up to 174 postgraduate scholarships—a one-time grant of $7,500 to pursue graduate studies—annually to student-athletes who excel academically and athletically and who are in their final year of intercollegiate athletics competition. Johns Hopkins men’s swimmer John Kegelman was the most recent recipient of the scholarship award. The mechanical engineering major, who received the award last May, had a 4.0 cumulative GPA and was a two-time captain for the men’s swim team and earned All-America honors five times in his career. G

3 0

Thurs., Nov. 19, noon. “Split Decisions: Regulating the End of the Cell Cycle,” a Cell Biology seminar with Kathy Gould, Vanderbilt University School of Medicine. Suite 2-200, 1830 Bldg. EB

Tues.,

13 — JHU teams represented in NCAA play during the 2008–2009 academic year

p.m.

“Injury Control in Professional and Recreational Athletes: An Occupational Safety and Health Issue,” a Graduate Seminar in Injury

Research and Policy with Andy Lincoln, Sports Medicine Research Center, Union Memorial Hospital. Third in the four-part series Occupational Injury, Safety and Health. Co-sponsored by Health Policy and Management and the Education and Research Center for Occupational Safety and Health. 250 Hampton House. EB “Impact of a Statewide Intensive Care Unit Quality Improvement Initiative on Hospital Mortality and Length of Stay,” a Health Policy and Management thesis defense seminar with Allison Lipitz. 688 Hampton House. EB

Mon., Nov. 30, 9 a.m.

Mon., Nov. 30, 10 a.m. “Marital Power and Intimate Partner Violence in the Philippines,” a Population, Family and Reproductive Health thesis defense seminar with Jessica Fehringer. E4130 SPH. EB

“The Prospect for a New New Deal?” a Sociology seminar with Frances Fox Piven, CUNY Graduate Center. 526 Mergenthaler. HW Mon., Nov. 30, noon.

Mon., Nov. 30, 12:15 p.m. “The Chromodomains of the Chd1 Remodeler Dictate Substrate Specificity Through an Autoinhibitory Mechanism,” a Carnegie Institution Embryology seminar with Gregory Bowman, KSAS. Rose Auditorium, 3520 San Martin Drive. HW

SPECIAL EVENTS Tues.,

Nov.

17,

12:15

p.m.

Native American Heritage Month—“Health Care Reform in Indian Country,” keynote address by Yvette Roubideaux, the first Native American woman appointed director of the Indian Health Service. Sponsored by the Center for American Indian Health and Native Circle. W1214 SPH (Sheldon Hall). EB Tues., Nov. 17, 8 p.m. MSE Symposium presents a lecture by actor, director and Academy Award–

nominated producer Sean Astin. (See photo, p. 12.) The lecture will be followed by a Q&A session and meet-and-greet. Shriver Hall Auditorium. HW THEATER Fri., Nov. 20, and Sat., Nov. 21, 8 p.m., and Sun., Nov. 22, 2 p.m. Johns Hopkins Uni-

versity Theatre presents student playwright Eric Levitz’s Tomorrow and Tomorrow and Tomorrow, with guest artist Mackenzie Astin. Directed by John Astin. Final performances. $15 general admission, $5 for students with ID, $13 for senior citizens, JHU faculty, staff and alumni. Merrick Barn. HW

Fri., Nov. 20, and Sat., Nov. 21, 8 p.m., and Sun., 22, 3 p.m.

Witness Theatre presents studentwritten one-act plays. Arellano Theater, Levering. HW “Nrytia Mala,” a performance exhibition of the classical Indian arts. Sponsored by JHU Shakti. Shriver Hall Auditorium. HW

Sat., Nov. 21, 6 p.m.

W OR K S HO P S

“Grantcraft,” a daylong workshop designed to assist faculty and advanced postdocs prepare an NIH or other peer-reviewed grant application. Sponsored by the JHMI Professional Development Office. Cost for faculty is $650; cost for postdoctoral and clinical fellows is $325. Registration required; to register, e-mail jhmipdo@jhmi.edu. Mountcastle Auditorium. EB

Mon., Nov. 16, 9 a.m.

Thurs., Nov. 19, 1 p.m. “Introduction to RefWorks,” a Bits & Bytes workshop intended for faculty, lecturers and TAs; staff are also welcome to attend. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW

November 16, 2009 • THE GAZETTE A R R A

R E S E A R C H

Goal: Find out if diet and exercise affect cardiovascular health By Lisa De Nike

Homewood

WILL KIRK / HOMEWOODPHOTO.JHU.EDU

veryone knows that a healthy diet and adequate exercise are effective weapons in the battle against obesity and type 2 diabetes. But do such regimens have the same positive impact on our cardiovascular system? People assume so and scientists think so, but—perhaps surprisingly—they don’t know for certain. “People are surprised when they hear that there really is very little data on the topic of whether diet and exercise, which are already recommended for treating obesity and diabetes, will also benefit cardiovascular health,” said Kerry Stewart, a professor of medicine in the Johns Hopkins University School of Medicine and director of Clinical and Research Exercise Physiology at Johns Hopkins Bayview Medical Center. “The evidence that exercise and a healthy diet in people with these conditions help the cardiovascular system is just not in yet.” In an effort to pin down the facts, Stewart and his team are embarking on two studies investigating whether the cardiovascular health of people who either have diabetes or are at risk of developing diabetes because they are overweight and sedentary shows improvement after the adoption of a healthy diet and exercise regimen. The cost of the studies—about $1.5 million for each—is underwritten by the federal stimulus package through the National Institutes of Health. “These two projects address some of our nation’s biggest public health problems: obesity, diabetes and cardiovascular health,” said Stewart, who recently presented groundbreaking data that revealed, among

Kerry Stewart and his team are embarking on two studies addressing some of the nation’s biggest health problems: obesity, diabetes and cardiovascular health.

other things, that weekly bouts of moderate aerobic exercise on a bike or treadmill, or a brisk walk, combined with some weightlifting may cut down levels of fat in the liver by up to 40 percent in people with type 2 diabetes. Stewart’s investigations are among the more than 300 stimulus-funded research grants totaling more than $148 million that Johns Hopkins has garnered since Congress passed the American Recovery and Revitalization Act of 2009 (informally known by the acronym ARRA), bestowing the National Institutes of Health and the National Science Foundation with $12.4 billion in extra money to underwrite research grants by

Consumer electronics can help improve patient health By Tim Parsons

School of Public Health

lectronic tools and technology applications for consumers can help improve health care processes such as adherence to medication and clinical outcomes like smoking cessation, according to a report by researchers at the Johns Hopkins Bloomberg School of Public Health. The analysis of consumer health informatics, conducted for the Agency for Healthcare Research and Quality by the Bloomberg School’s EvidenceBased Practice Center, was based on an examination of 146 published research studies of patient-focused electronic tools. It is among the first to explore the potential value of consumer health informatics. Consumer health informatics applications are defined as any electronic tool, technology or electronic application designed to interact directly with consumers, with or without the presence of a health care professional, to provide or use individualized personal information to help a patient better manage his or her health or health care. Personalized informatics tools can include applications such as online health calculators, interactive computer programs to aid decision making, and SMS text and e-mail messages, which can be applied to a variety of clinical

conditions, including cancer, smoking, diabetes mellitus, physical activity and mental health disorders. “Consumer electronics are changing the way we shop, bank, communicate and even elect our presidents. We wanted to know if there was any evidence that these types of tools could impact health,” said lead author Michael Christopher Gibbons, an assistant professor in the Bloomberg School’s Department of Health, Behavior and Society. “In the future, these tools may help make health care much more patientcentered and available when needed, and not just available when the office is open. They may also help us improve health disparities by increasing patient access to health-improving treatments and interventions among the poor and uninsured.” Overall, the analysis found no evidence that consumer health informatics harmed consumers. In addition, there was insufficient evidence to determine if consumer health informatics provided any economic or cost benefit. Additional authors of the report are Renee F. Wilson, Lipika Samal, Christoph U. Lehmann, Kay Dickersin, Harold P. Lehmann, Hanan Aboumatar, Joe Finkelstein, Erica Shelton, Ritu Sharma and Eric B. Bass, all of Johns Hopkins. The full report is available at www .ahrq.gov/downloads/pub/evidence/pdf/ chiapp/impactchia.pdf.

September 2010. The stimulus package— which provided $550 billion in new spending, including the above grants, and $275 billion in tax relief—is part of President Barack Obama’s plan to kick-start a stagnant economy by doling out dollars for transportation projects, infrastructure building, the development of new energy sources and job creation, and financing research that will benefit humankind. As of this month, Johns Hopkins scientists have submitted nearly 1,300 proposals for stimulus-funded investigations ranging from strategies to help recovering addicts stay sober and the role that certain proteins play in the development of muscular dystro-

phy to mouse studies seeking to understand how men and women differ in their response to the influenza virus. Stewart’s studies, each of which will last six months, will examine the cardiovascular effects of exercise and diet on overweight and obese people with type 2 diabetes or at risk for developing diabetes, and on people with abdominal obesity, which puts them at a higherthan-average risk of several early markers for cardiovascular disease, including endothelial function, arterial stiffness and dysfunction of the heart’s ability to fill with blood. The first study will enroll about 76 participants and will ascertain whether a diet alone or a diet plus exercise has a more positive impact on cardiovascular health. The second study will enroll the same number of subjects and will compare whether a low-carbohydrate diet plus exercise is better for cardiovascular health than is a low-calorie, low-fat diet plus exercise. “We expect our subjects to become more fit, lose weight and lower their blood sugar,” Stewart said. “What we don’t know is if these changes will also lead to improved cardiovascular health and ultimately—and this is key—the prevention of cardiovascular disease. If our results are positive, this would provide further and convincing evidence about the role of diet and exercise as a vital pathway to heart health.” This is part of an occasional series on Johns Hopkins research funded by the American Recovery and Revitalization Act of 2009. If you have a study you would like to be considered for inclusion, contact Lisa De Nike at lde@jhu .edu.

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8 THE GAZETTE • November 16, 2009 F O R

Cheers Cheers is a monthly listing of honors and awards received by faculty, staff and students plus recent appointments and promotions. Contributions must be submitted in writing and be accompanied by a phone number. ACADEMIC CENTERS AND AFFILIATES Jhpiego was named an Innovator of the

Year by The Daily Record in recognition of its efforts to save the lives of women and their families by creating low-cost health solutions that can be utilized in remote locations with few resources, such as running water or electricity, around the world. This year, the Maryland publication received more than 80 nominations for the honor; 25 winners were selected. BAYVIEW MEDICAL CENTER Kathleen Barnes , director of the Genetic

Research Facility and of the Lowe Family Genomics Corp., has been promoted to professor of medicine. Barnes is also the Mary Beryl Patch Turnball Scholar within the Center for Innovative Medicine in the Division of Allergy and Clinical Immunology. S t e v e n K r a v e t , president of Johns Hopkins Community Physicians, has been promoted to associate professor of medicine. Kravet previously served as deputy director for clinical activities within the Department of Medicine.

BLOOMBERG SCHOOL OF PUBLIC HEALTH Betty H. Addison , director of Career

T H E

Services and Disability Support, has been appointed to the Planned Parenthood of Maryland board of directors for a three-year term. Abdullah H. Baqui has been promoted to professor in the Department of International Health. Joel Gittelsohn has been promoted to professor in the Department of International Health. Robert S. Lawrence , director of the Center for a Livable Future, has been presented with the Sedgwick Award Medal for Distinguished Service in Public Health, the American Public Health Association’s oldest and most prestigious award. Lawrence received the award at the Public Health Awards Reception and Ceremony on Nov. 11 in Philadelphia, at the close of APHA’s 137th Annual Meeting and Exposition. Terence H. Risby has been appointed professor emeritus in the Department of Environmental Health Sciences. Peter J. Winch has been promoted to professor in the Department of International Health. JOHNS HOPKINS MEDICINE Mark Bittle , vice president of ambula-

tory services, has been chosen chair-elect of the Health Administration Section of the American Public Health Association.

KRIEGER SCHOOL OF ARTS AND SCIENCES Christopher Carroll , a professor in the

Department of Economics, has been named a senior economist for macroeconomics on the White House’s Council of Economic Advisers, which assists the president with

R E C O R D

the development and implementation of the nation’s economic policy. Led by a chair and two members, the council’s team of economists, forecasters and statistical experts draw upon evidence-based research to provide the president with thorough and timely economic analysis. Martha Abele Mac Iver , a research scientist in the Center for Social Organization of Schools, has received a Senior Urban Education Research Fellowship, known as SUERF, from the Council of the Great City Schools. Mac Iver’s project, “Identifying the Early Warning Signals of Dropout Outcomes in the Baltimore City Public Schools,” will explore the causes of dropout and also the school and teacher practices that can help to reduce the incidence of ninth-grade failure in Baltimore and other urban districts. The U.S. Department of Education awarded the Council of the Great City Schools, a coalition of the nation’s large urban public school systems, more than $2.5 million in September 2006 to establish the SUERF program. This is the third round of fellowship grants, awarded annually to three senior education researchers. SCHOOL OF MEDICINE Jaishri Blakeley , assistant professor of

neurology, oncology and neurosurgery and director of the Johns Hopkins Comprehensive Neurofibromatosis Center, has received the 2009 Make a Difference Award from Neurofibromatosis Mid-Atlantic, a 30-yearold nonprofit support organization that provides information on the disorder. Blakeley was nominated for the award by one of her patients.

Charles E. Connor has been promoted to professor of neuroscience. R o m e r g r y k o G e o c a d i n , associate professor of neurology, neurosurgery and anesthesiology/critical care medicine, has been named director of the Neurosciences Critical Care Division and the Neurosciences Critical Care Unit at The Johns Hopkins Hospital. Geocadin previously was associate director of the same-named division and unit at Johns Hopkins Bayview Medical Center. Leon Gordis has been appointed professor emeritus in the Department of Pediatrics. John E. “Jack” Grinnalds , senior director of facilities management, received the honor of IFMA Fellowship at the International Facility Management Association’s Awards of Excellence banquet on Oct. 9 in Orlando, Fla. Grinnalds oversees a budget of $121 million and a staff of 245 for 23 buildings. Being named an IFMA Fellow is the highest honor the association can bestow on a member. To date, only 83 professionals have received this distinction. James E. Loesch , the plant facilities chief engineer and project management office supervisor at APL, was named a fellow in 2002. Ahmet Hoke has been promoted to professor of neurology. Gregor y L. Krauss has been promoted to professor of neurology. Ira Papel , associate professor of facial plastic surgery, has been elected to a threeyear term as president of the American Board of Facial Plastic and Reconstructive Surgery. Continued on next page

New ‘schizophrenia gene’ prompts test of potential drug target By Maryalice Yakutchik

Johns Hopkins Medicine

ohns Hopkins scientists report having used a commercially available drug to successfully “rescue” animal brain cells that they had intentionally damaged, by manipulating a newly discovered gene that links susceptibility genes for schizophrenia and autism. The rescue, described as “surprisingly complete” by the researchers, was accomplished with rapamycin, a drug known to act on a protein called mTOR, whose role involves the production of other proteins. The idea to test this drug’s effectiveness at rescuing impaired nerve cells occurred to the team as a result of having discovered a new gene that appears to act in concert with two previously identified schizophrenia susceptibility genes, one of which is involved in the activation of the protein mTOR. This piecing together of multiple genes adds support for the idea that suscep-

tibility to schizophrenia and autism may have common genetic fingerprints, according to the researchers. In a report on the work published in the Sept. 24 issue of the journal Neuron, the scientists are careful to say that the genes in question are not the cause of schizophrenia or any other brain/mind disorder in humans. However, these genes do appear to serve as a blueprint for proteins that consistently pop up in a range of mental illnesses in people. The newfound gene, dubbed KIAA1212, serves as a bridge linking two schizophrenia genes: DISC1 and AKT. Suspecting KIAA1212 as one of many potential binding partners interacting with DISC1, whose name is an acronym for “disrupted in schizophrenia,” the researchers genetically shut down the production of DISC1 proteins in newly born neurons in the hippocampus region of an adult mouse brain. The hippocampus contains a niche where native stem cells give rise to fully developed new neurons. The idea was to deliberately cause

these cells to malfunction and then watch what happened. The scientists found that the newborn neurons were most noticeably defective 14 days after DISC1 suppression and that they were defective in a variety of ways. By manipulating AKT production, or altering KIAA1212, they discovered the very same abnormalities as with DISC1 deficiency, concluding that KIAA1212 is in the same signaling pathway as DISC1 and AKT. Because mTOR is a well-known downstream effector of AKT, the researchers treated the adult mice harboring those abnormal neurons with rapamycin, a drug known to alleviate the effects of a faulty AKT pathway. It effectively “rescued” the neurons from their defects. “Our discoveries give us more of the information we need to understand the function of genes associated with psychological diseases,” said Guo-li Ming, an associate professor of neurology and neuroscience in the School of Medicine’s Institute for Cell Engineering, known as ICE. “The next step is to create SPECTRUM 1-16 GAZETTE 8-08:Layout 2

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Hongjun Song:

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a good animal model that would allow us to test whether candidate drugs will reverse not only the irregularities of brain cells with deficiency of these genes but also behaviors.” The new neurons with alterations of DISC1, KIAA1212 or AKT in the brains of the rapamycin-treated mice developed normally, said Hongjun Song, an associate professor of neurology in ICE, who collaborated in the research. “What was amazing to us is how potent the drug is, at least on the cellular level,” said. 1“A number of 8/28/08 10:26 AM hePage the neurons’ developmental defects—from enlarged cell size to the misplacement of cell localization and abnormal neuronal processes involved in receiving and sending messages—were corrected by this one drug.” This study was supported by the National Institutes of Health, McKnight Foundation, NARSAD, International Mental Health Research Organization, Maryland Stem Cell Research Fund and March of Dimes. Authors on the paper, in addition to Ming and Song, are Ju Young Kim, Xin Duan, Cindy Y. Liu, Mi-Hyeon Jang, Junjie U. Guo, Nattapol Pow-anpongkul and Eunchai Kang, all of Johns Hopkins.

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November 16, 2009 • THE GAZETTE

Cheers Continued from preceding page Richard B.S. Roden has been promoted to professor of pathology, oncology and gynecology/obstetrics. John T. Walkup has been promoted to professor of psychiatry. Jon D. Weingart has been promoted to professor of neurosurgery. Robert G. Weiss has been appointed first holder of the Clarence Doodeman Professorship in Cardiology. SCHOOL OF NURSING Michael Vaughn has been named the

inaugural assistant dean for information technology and integration. He comes to Johns Hopkins from Indiana University,

Milestones The following staff members recently retired or celebrated an anniversary with the university in November 2009. The information is compiled by the Office of Faculty, Staff and Retiree Programs, 443-997-6060. ACADEMIC AND CULTURAL CENTERS

15 years of service K i l l e b r e w, Justin, Krieger Mind/Brain Institute 5 years of service Towanda, Center for Talented Youth F o r d , Michael, Institute for Policy Studies S a x t o n , Laura, Center for Talented Youth W i t t , Dori, Center for Talented Youth Brown,

BLOOMBERG SCHOOL OF PUBLIC HEALTH

where he served as assistant dean for information systems and implemented the first schoolwide course management system, a fully distance-accessible option for the PhD program and the construction of a stateof-the-art clinical simulation facility. He was also instrumental in establishing the IU School of Nursing Lifelong Learning Department as a global provider of online continuing education offerings, reaching more than 1,500 individuals annually. Kathleen White , associate professor and director of the Doctor of Nursing Practice program, was presented the Maryland Nurses Association Outstanding Leadership Award on Oct. 15 at the organization’s 106th annual convention. White began her leadership career with the MNA in 1980 and later became president. She currently serves as the chair of the American Nursing Association’s Congress on Nursing Practice and Economics.

KRIEGER SCHOOL OF ARTS AND SCIENCES

10 years of service G r a d e t , Howard, Center for Social Organization of Schools M a o u y o , Ann, Center for Social Organization of Schools 5 years of service G a i n e s , Kristen, Earth and Planetary Sciences M c G h e e , Scott, Chemistry PEABODY INSTITUTE

15 years of service P a r k e r , Audrey, Development SAIS

20 years of service E a r l e , Sydney, Human Resources 5 years of service C a m e r o n , Erin, Admissions and Joint Degree Programs SCHOOL OF EDUCATION

Retiree

30 years of service S m i t h , Michael, Epidemiology

Nicodemus,

20 years of service C a r i s , Miriam, Epidemiology J o n e s , Rachel, Health Policy and Management K o n i g , Judith, Epidemiology

5 years of service William, Center for Technology in Education M o g i l e v i c h , Polina, Information Technology Systems and Services O t t , Elizabeth, Center for Technology in Education

15 years of service A b r a m s , Chad, Health Policy and Management A w a s u m , David, Center for Communication Programs R o b e r t s , Peter, Center for Communication Programs 10 years of service G i l m o r e , Joyclyn, Biostatistics L e a c h , Angela, Custodial Services 5 years of service D a v i s , Mary, Custodial Services M o r r i s , Susan, International Health CAREY BUSINESS SCHOOL

5 years of service M o g i l e v i c h , Polina, Business and Financial Services HOMEWOOD STUDENT AFFAIRS

Retiree Va u l i n a m ,

Carol, 28 years, Housing and Dining Services 15 years of service Concordia, Student Health and Wellness Center

Siebert,

10 years of service G r a y , Kimberly, Budget Administration JOHNS HOPKINS UNIVERSITY PRESS

25 years of service K e l l y , Melinda, Customer Service and Administration 5 years of service C o x , Milton, Fulfillment

Services

Cheri, 10 years, Academic

Blandford,

SCHOOL OF MEDICINE

Retirees F i l l i u s , Ruby, 20 years, Urology F i s h e r , James, Jr., 15 years, Infectious Diseases F u l l w o o d , Linda, 28 years, Anesthesiology H o a g l a n d , Patricia, 32 years, Chemical Dependency K i m , Chung, 36 years, Welch Medical Library R o d m a n , Alice, 11 years, Center for Clinical Global Health Education 35 years of service E d m o n d s , Bernice, Marketing 30 years of service M a s o n , Ruby, Pediatrics P a y n e , Edward, Research Animal Resources S o a p e r , Michael, Pulmonary

25 years of service B a n k e r t , Joyce, Biomedical Engineering D e b a u f r e , Mary, Geriatrics F e d o r , Helen, Pathology J e l e n , Janet, Welch Medical Library K e h o e , Marjorie, Welch Medical Library K e m m e r , Dana, Cardiology M e i s e , Shannon, Pulmonary W a t k i n s , James, III, Pulmonary

20 years of service B a i l e y , Sandra, Oncology B a y n e s , John, Jr., Pulmonary B u c k l e r , Sandra, Clinical Investigation Human Subjects B u k o w s k i , James, Environmental Health Services

the Department of Electrical and Computer

Engineering, is one of 11 “trailblazers” in science, technology and business chosen to be honored as 2010 Franklin Institute Laureates. Since 1824, the Philadelphia-based institute, founded in honor of Benjamin Franklin, has given awards to many prominent figures, including Albert Einstein, Thomas Edison, Marie and Pierre Curie, Orville Wright and Jane Goodall. West and the other honorees, who include Microsoft co-founder Bill Gates, will be celebrated April 29 at a black-tie ceremony and dinner, considered to be one of the preeminent social events in Philadelphia. West, along with Gerhard M. Sessler of the Darmstadt University of Technology in Germany, will receive the Benjamin Franklin Medal in Electrical Engineering in honor of their work in the 1960s as Bell Labs researchers who invented the first practical and inexpensive electret microphone, which continues to be used in telephones and many other electronic devices.

M o r a n , Wanda, Pulmonary R o b e r t s , Dale, Neurology W i l l i a m s , Clifton, Finance

S h e l b y , Melissa, Surgery S t o k e s , Charteia, Clinical Operations S y v e r s e n , Eric, Research Animal

UNIVERSITY ADMINISTRATION Stephanie Reel , vice provost for infor-

mation technologies and Johns Hopkins Medicine’s vice president for information services, has been appointed to the President’s Council of Advisors on Science and Technology. Created by President Barack Obama in April, the 18-member group of leading scientists and engineers directly advises the president and the Executive Office of the President on science, technology and innovative policies. In announcing formation of the group, which is administered by the Office of Science and Technology Policy, Obama said he wanted it to advise him on national strategies “to nurture and sustain a culture of scientific innovation.”

WHITING SCHOOL OF ENGINEERING James E. West , a research professor in

15 years of service H e n s l e y , Sandra, Psychiatry J a c k s o n , Theresa, Facilities Support Services L e n s c h , Kathleen, Cardiology M a y f i e l d , Georgia, Facilities Support Services M i h a i l , Lee Ann, Psychiatry R u d o w , Gay, Pathology S t i r l i n g , Wanda, Pathology W i t t , Brenda, Orthopedic Surgery W o o d a r d , Angela, Facilities Support Services 10 years of service A g i u s , Marijke, General Internal Medicine A n d e r s o n , Shirley, Dermatology B e a d s , Steven, Oral Surgery B e e c h , Breon, Genetic Research Core Facility B r a n d e n b u r g - C o b b , Sheri, Molecular Medicine B r u c e , Audrey, Obstetrics and Gynecology B y f i e l d , Monica, Fund for Johns Hopkins Medicine F r i s b y , Darlene, Obstetrics and Gynecology K a m i n e t z , Michael, Facilities Design and Construction L e v i n e , Claire, Anesthesiology M c C a f f e r y , Janet, Orthopedics M i c h a l s k i , Katherine, General Internal Medicine P r i c e , Yvette, Facilities Support Services S a u n d e r s , Joy, Johns Hopkins Technology Transfer S m i t h , Amy, Anesthesiology S t u a r t , Valerie, Cardiology W e i n e r , Phillip, Oncology Z e i l o n , Rebecca, Fund for Johns Hopkins Medicine 5 years of service B l y t h , Juliane, Policy Coordination B o l i e k , Janet, Research Animal Resources C h a s e , Nina, Infectious Diseases C o r n e l i s o n , Patrick, Neurology C o t t i n g h a m , Patrick, Surgery D e v i v a , Kimberly, Neurology D i m i c k , Alison, Endocrinology F l e t c h e r , Amy, Ophthalmology H a i n e s , Jamie, International Services H a l l , Angelica, Pediatrics H a r i h a r a n , Pradeep, Clinical Investigation

Human Subjects

H a z e l t o n , Diane, Clinical Operations H i o t e s , John, Clinical Investigation

Human Subjects H o r n e , Amy, Obstetrics and Gynecology H o w e , Megan, Gastroenterology J o h n s o n , Joann, Pediatrics L a r k i n , Kristen, Obstetrics and Gynecology L e w i s , Tavon, Research Animal Resources M e n n i t t o , Donna, Psychiatry M u l l i n s , Marissa, Rheumatology N e l s o n , Andrea, Psychiatry N o v a k , Jessica, Neurology P a t e , Kimberly, Oncology Q a z i , Umair, Surgery S e y a l , Sonja, Ophthalmology S h e c k e l s , James, Oncology

Resources

T h o m p s o n , George, Sr., Dermatology W a n g , Aiping, Pathology

SCHOOL OF NURSING

20 years of service O ’ R o u r k e , Mary, Admissions SHERIDAN LIBRARIES/ JHU MUSEUMS

10 years of service E d w a r d s , Thomas, MSE Library UNIVERSITY ADMINISTRATION

Retirees Eldridge,

Katherine, 29 years, Human Resources G a s k i n s , Carolyn, 29 years, Human Resources 30 years of service G r e g o r e k , Joan, Financial Systems 25 years of service B e h r , Douglas, Marketing and Creative Services E l t e r m a n , Judith, Information Technology 15 years of service G o o d m a n , Angela, Student Information Systems W i l c o x , Timothy, Sr., Building Operations and Maintenance 10 years of service H a l l , Katie, Data Administration H a n l i n , Brian, Financial and

Administrative Services

H a n n , Joanne, IT Systems R i c h a r d s o n , Alicia, Administrative

Services

T h e y s , Joann, Finance Tu c k e r , Marion, Data Administration

5 years of service D a v i s , Jillian, Annual Giving F r a n k s , Danielle, Research Administration H i n e r , Cynthia, Jhpiego J e f f r e y , Stephen, Development Research R o d r i g u e z , Carlos, Student Information Systems S o m e r s , Pamela, Organization Development Diversity W a s h i n g t o n , Jean, Career Management Program WHITING SCHOOL OF ENGINEERING

Retiree Williams,

Rosemary, 28 years, Engineering and Applied Science Programs for Professionals

10 years of service Marybeth, Center for Bioengineering Innovation and Design Camerer,

5 years of service A h m a n s o n , Elisa, Engineering Research Center

10 THE GAZETTE • November 16, 2009 B U L L E T I N

Notices Toys for Tots — The Department of Elec-

trical and Computer Engineering is once again setting up a drop-off location for the Marine campaign for Toys for Tots. New toys, in their original store wrappings, may be dropped off in 105 Barton Hall on the Homewood campus through Friday, Dec. 11. No holiday wrapping or used toys please. For more information, go to www .toysfortotsbaltimore.org or e-mail Candace Abel at cabel@jhu.edu.

FSRP Holiday Programs — Through the Vernon Rice Memorial Butterball Turkey and Adopt-a-Family programs, Faculty, Staff and Retiree Programs provides opportunities for members of the Johns Hopkins community to help local families in need during the holidays. The Vernon Rice Memorial Butterball Turkey Program, named in honor of the late Johns Hopkins staff member who started the effort, provides Butterball Turkey gift certificates to pre-identified families through St. Anthony of Padua Church in West Baltimore. In 2008, thanks to the generosity of Johns Hopkins faculty and staff, 113 families received certificates for holiday meals. To participate, send a check or money order in $15 increments, payable to JHU Butterball, to Faculty, Staff and Retiree Programs, Johns Hopkins at Eastern, 1101 33rd St., Suite C100, Baltimore, MD 21218. Funds received by Nov. 13 will be given to families for Thanksgiving, and those received after Nov. 14 but before Dec. 15 (the final day for contributions) will be distributed for the December holidays. Go to http://hr.jhu.edu/fsrp/butterball.cfm for more information on the program. The Adopt-a-Family/Adopt-an-Agency Program provides families and individuals with gifts, clothing and food that they might not otherwise be able to afford. Johns Hopkins faculty and staff adopt a pre-identified

P O S T I N G S

B O A R D

Job Opportunities

family or social service agency and collect gifts to match specific needs. These wish lists are available to faculty, staff or departments. To learn more about this program, or to complete an online registration form, go to http://hr.jhu.edu/fsrp/adopt_fam.cfm. Contact FSRP at 443-997-6060 with questions about either program, or go to http://hr.jhu.edu/fsrp and click on the Community Service link to learn more. Tutoring at Harriet Lane Clinic — Vol-

unteers are needed for the tutoring program serving patients of the Harriet Lane Clinic, which is the general pediatrics outpatient center on the East Baltimore medical campus, during the spring semester. Tutoring is conducted in math and reading with the intent to boost each child’s skills up to grade level. Materials are provided, and tutors are supported by knowledgeable staff and faculty. Times are 4 to 6 p.m. on Mondays and Wednesdays, and the clinic can be reached from Bayview and Homewood by the JHU shuttle. One two-to-three-hour training session is required. Tutors must have at least a GED or high-school diploma, take a TB test (or have a negative X-ray taken after Nov. 1) and get a copy of their measles, mumps and rubella test record (if born after Jan. 1, 1957). To volunteer or for more information, contact Robyn Nuttall at rnuttal1@ jhmi.edu.

Minority Global Health Disparities Research Program for KSAS Undergrads — One student from the School of

Arts and Sciences will be chosen to participate in the Minority Global Health Disparities Research Program, known as MHIRT, which consists of a summer internship for up to three months (June–August). Applications and information on the program and research locations are available in 237 Mergenthaler, Homewood campus, and online at www.krieger.jhu.edu/research/globalhealth .html. An application and two recommendation letters must be turned in to Lisa Jia, 237 Mergenthaler, no later than Tuesday, Nov. 24.

The Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

Homewood

Office of Human Resources: Suite W600, Wyman Bldg., 410-516-8048 JOB#

POSITION

41040 41068 41428 41564 41663 41343 41467 41521 41593 41610 41651 41766 41783

Development Coordinator Network Security Engineer II Program Associate Sr. Systems Engineer IT Project Manager IT Computing and Project Manager Shop Foreman Research Technologist Registration Manager IT Specialist Research Imaging Assistant Web Developer Database Developer

Schools of Public H e a l t h a n d N u r s i n g Office of Human Resources: 2021 East Monument St., 410-955-3006 JOB#

POSITION

41461 41562 41151 41844 41456 41473 41388 40586 40189 40889 41398 41841 41049 41232 40927 41380

Administrative Coordinator IT Service Coordinator Research Assistant Outreach Worker Research Specialist Program Specialist Program Officer Project Director, Research 2 Prevention Laboratory Assistant Program Coordinator Research Data Analyst Research Assistant Regulatory Coordinator Academic Program Coordinator E-Learning Coordinator, PEPFAR Strategic Project Coordinator

School of Medicine

41358 41440 41513 41616 41715 41720 40463 41754 41817 40562 40783 40915 41161 41406 41503

Research Services Librarian for History and Curator of 19ththrough 21st-Century Books and Manuscripts Head of Library Systems Bioethics Research Project Specialist Preservation Intern Bioethics Research Project Specialist Museum Aide Research Service Analyst Copy Cataloguer Financial Manager Academic Services Specialist Academic Services Assistant Fulfillment Specialist Sr. Technical Support Analyst Career Services Counselor Director, Multicultural Affairs

41197 40237 40912 41561 39308 41265 39306 39296 41414 41785 41277 40770 40758 40328 38840 41085 40996 41204 38886 41387 41463 40769 39063 41451

Sr. Program Officer II/Team Lead Program Officer II Clinic Assistant Sr. Sponsored Project Analyst Software Engineer Fogarty Program Coordinator Programmer Analyst Data Assistant Research Technologist Sr. Program Officer Research Program Coordinator Sharepoint Developer Physician Assistant YAC Co-Facilitator Communications Specialist Program Coordinator Sr. Research Nurse Assistant Director, MHS Program Research Assistant Deputy Project Director, Advance Family Planning Research and Evaluation Officer Software Engineer Research Assistant Multimedia Systems Specialist

37890 37901

Sr. Research Program Coordinator Casting Technician

Office of Human Resources:

98 N. Broadway, 3rd floor, 410-955-2990 JOB#

POSITION

38035 35677 30501 22150 38064 37442 37260 38008 36886

Assistant Administrator Sr. Financial Analyst Nurse Midwife Physician Assistant Administrative Specialist Sr. Administrative Coordinator Sr. Administrative Coordinator Sponsored Project Specialist Program Administrator

This is a partial listing of jobs currently available. A complete list with descriptions can be found on the Web at jobs.jhu.edu.

Woodcliffe Manor Apartments

S PA C I O U S

G A R D E N A PA RT M E N T L I V I N G I N

R O L A N D PA R K

• Large airy rooms • Hardwood Floors • Private balcony or terrace • Beautiful garden setting • Private parking available • University Parkway at West 39th St. 2 & 3 bedroom apartments located in a private park setting. Adjacent to Johns Hopkins University Homewood Campus and minutes from downtown Baltimore.

410-243-1216

105 West 39th St. • Baltimore, MD 21210 Managed by The Broadview at Roland Park BroadviewApartments.com

November 16, 2009 • THE GAZETTE

Classifieds APARTMENTS/HOUSES FOR RENT Bolton Hill, two 1BR, 1BA apts, clean, nice, attentively managed bldgs, walk to JHH shuttle and subway. gbaranoski@covad.net. Butchers Hill, cozy, cottage-style 1BR + office in fully furn’d RH, Wifi, satellite sys, sec sys, mins to JHH/JHMI, 2 blks to shuttle, nr park. 410-988-3137 or hsinream31886@gmail.com. Charles Village, charming, renov’d 5BR, 2BA house, master/walk-in, hdwd flrs, W/D, porch, deck, beautiful inside, nr shuttle. $2,400/mo + utils or $2,100/mo (short-term). 443-803-3572 or ramsaybarnes@gmail.com. Charles Village, corner 2BR, 2BA condo w/balcony, 1,200 sq ft, CAC, 24-hr front desk, steps to JHU shuttle, all utils incl’d. marionmalcolm@comcast.net.

M A R K E T P L A C E

Loch Raven Village (Towson), 3BR, 1.5BA brick TH, AC, W/D, fin’d bsmt, backyd w/ deck, nr beltway/schools/shopping, no pets, avail Dec 1. $1,200/mo + utils. wwang1268@ yahoo.com. Mt Washington, 2BR, 2BA condo w/lg loft, 1,300 sq ft, hdwd flrs, balcony, fp, W/D, dw, elevator, garage. $1,500/mo. 301-525-4505 or ufruth@yahoo.com. Mt Washington, 5BR, 3.5BA house, 3 yrs old, 2-car garage. $2,500/mo + utils. 443-939-6027 or qzzhao@gmail.com. Mt Washington, 3BR, 3.5BA TH, AC, heat, W/D, hdwd and crpt flrs, deck, 2 prkng spaces, nice neighborhood, 10-20 mins to JHU/JHH, nr Summit Park ES. $1,750/mo + utils. 410419-1731.

shops/grocer. $278,000. 919-607-5860 or 410962-5417.

ROOMMATES WANTED Prof’ls wanted for 1BR in 3BR, 2.5BA RH, 3 blks to JHH, pref nonsmoker. $500/mo incl utils, high-speed Internet. 703-944-8782. Roommate needed. $750/mo incl utils, wireless Internet. 443-865-2050 or Lth1980@gmail.com. Rm in lg, furn’d house in Catonsville, nr park/695/95, no lease, W/D, deck, backyd. $625/mo + utils (high-speed Internet incl’d). 410-409-0692 or Lizo99@hotmail.com. Lg, partly furn’d bsmt BR w/priv BA avail in beautifully renov’d 3BR RH in Mayfield, across from Herring Run Park, nr Lake Montebello, 10 mins to JHMI, perf for visiting medical prof’ls. $600/mo incl utils and wireless. mayfieldroom@gmail.com. Furn’d 1BR/BA in 2BR condo, quiet, secure bldg, walk to JHMI shuttle/Homewood, shortterm OK. $750/mo incl utils. 410-366-8360.

Owings Mills, furn’d 1BR condo w/vaulted ceilings, sunrm, $2,200/mo (negotiable) incl utils, FIOS, phone, Internet, W/D. 240-88-4388 or nadiaopalangel@gmail.com.

Share spacious 3BR, 2BA TH in Towson/ Parkville w/F and dog, laundry, yd, prkng, 5 mi to Homewood. $700/mo incl utils, wireless. 410-790-4552.

Charles Village, spacious rm avail at 31st and Calvert, month-to-month, no sec dep. 443527-2682.

Patterson Park, 2BR, 1.5BA house, hdwd flrs, crpt upstairs, stainless steel appls, skylight, expos’d brick, 1.25 mi to JHMI. $1,100/mo. 443-286-4883.

Furn’d rm on JHMI campus, safe area, share common area w/F doctor. 301-324-2470 or happyhut4u@yahoo.com.

Charles Village EOG, commercial/residential lease, charming, lots of light, sec dep, credit check and commercial zoning waiver req’d. 443-756-6707.

Randallstown, 3BR house w/fin’d bsmt, huge deck, quiet area, 10 mins to Owings Mills metro. $1,440/mo. 410-655-5346.

Charles Village (2807 Calvert St), lg 3BR, 2BA apt w/sunrm, W/D, hdwd flrs, eat-in kitchen, other units avail. 410-383-2876.

Cross Keys Village, 1BR condo w/hdwd flrs, CAC/heat, free prkng, 24-hr security, swimming pool. $900/mo + utils (water incl’d). 646-284-2279 or tamrirev@yahoo.com. Cross Keys, updated 1BR condo in secure, gated community, assigned prkng, swim, tennis, nr hospital and university. $1,000/mo + utils or $1,200/mo incl utils. 410-375-7748. East Chase St, luxury 1BR, 1BA apt, 540 sq ft, 9' ceiling, new dw, laundry on same flr, 24-hr security, walk to Peabody, monument, arts district, Penn Station and light rail. $800/mo + utils. 443-388-2802 or dfbls@yahoo.com. Fells Point (Aliceanna and Broadway), 2BR, 2BA apt w/top-of-the-line appls, granite countertops, 2 blks to water, bike to Hopkins. $1,595/mo. 805-338-2277. Hampden, cute, totally renov’d 1BR, 1BA apt, perf for couple/single, new Berber crpt, updated electric and plumbing, W/D, access to bsmt and sm backyd for storage, pets OK. $775/mo + utils. 410-227-8879 or abillian@sshb.com. Hampden (41st St), 3BR apt w/new BA, new paint, living rm, dining rm, kitchen, pantry, dw, W/D, garage. $1,275/mo incl utils. 410338-4455. Hampden, 3BR, 2BA TH, dw, W/D, fenced yd, nr light rail. 410-378-2393.

Lg, sunny 1BR apt, 2nd flr, eat-in kitchen, plant rm, living rm. $625/mo + utils. 410-610-0084. 1BR apt in safe area nr Rotunda, avail late November. $685/mo incl heat, water, gas. 443854-4239.

Master rm w/priv BA avail in 2BR apt in the Carlyle, avail from now to January. $700/mo. 410-375-0394.

Take over lease (9 months remaining) for loft apt, 1,250 sq ft, updated kitchen w/stainless GE appls, 2 lg BRs, full BA and sm office/den on 2nd flr, spacious living area, kitchen and half-BA on 1st flr. $1,325/mo. 978-590-9148 or hat0565@gmail.com.

Share new, refurbished TH w/other medical students, 4BRs, 2 full BAs, CAC, W/D, dw, w/w crpt, at 924 N Broadway, 1-min walk to JHMI. gretrieval@aol.com.

ITEMS FOR SALE HOUSES FOR SALE Canton (3135 Dillon St), 2BR, 2.5BA house w/open floor plan, roofdeck, great location. $339,000. ac3135@yahoo.com. Mt Vernon, huge 3BR beaux arts apt, very elegant, light and quiet, opposite shuttle, overlooks square. $549,000. 202-236-2200. Patterson Park, renov’d 3BR, 2BA house facing park, 1 mi to JHH. $289,000. 410-675-4817 or skj2428@yahoo.com. Timonium (8 Tyburn Ct), updated, spacious 4BR, 3BA single-family house on cul-de-sac, move-in cond, walk to Dulaney High, 2 mi to I-83 and lt rail station. $375,500. Debbie, 410-241-4724.

Homewood area, spacious 3BR apt w/hdwd flrs, 10' ceiling, new windows, in secure bldg. 443-253-2113 or pulimood@aol.com. Homewood/Guilford, 1BR high-rise condo, doorman/security, pool, prkng utils incl’d. anthony8066@gmail.com.

Wyman Park, bright 2BR co-op overlooking park next to Homewood campus, easy walk to JHMI shuttle. $142,900. 443-615-5190.

SPECIAL DISCOUNTS FOR JHH EMPLOYEES!

249 S Castle St, excellent, completely renov’d RH w/gourmet kitchen, walk to JHMI/Fells Point/Canton, open house Sundays, noon-2pm. $279,000 ($5,000 closing help). 301-730-0159.

A full-service practice for all your dental health needs.

We provide the best quality dental care with a comprehensive range of services, including: COSMETIC • RESTORATIVE • PREVENTIVE • SURGICAL ROOT CANALS • CROWNS • BRIDGES DENTURES • INVISALIGN To schedule an appointment, call us at

(410)502-8565 or (410)502-8566 or stop in to see us at 1000 East Eager Street, Baltimore, MD 21202

Johns Hopkins / Hampden WYMAN COURT APTS. (BEECH AVE.) Effic from $570, 1 BD Apt. from $675, 2 BD from $775 HICKORY HEIGHTS APTS. (HICKORY AVE.) 2 BD units from $750 Shown by Appointment 410-764-7776

www.brooksmanagementcompany.com

Share newly renov’d RH (Calvert St), laundry, dw, heat, AC. $350/mo + utils. Ezra, 443-2073533 or Paul, 443-739-5070. Share Hampden house w/30-yr-old F prof’l and dog, dogs welcome. $650/mo + utils. 201-8883274 or nicolejward@gmail.com.

Upper Fells Point, 3BR, 3.5BA RH, remodeled 6 yrs ago, stainless steel kitchen, hdwd flrs, AC, W/D, roofdeck, ideal for roommates, nr JHMI. $249,000. www.209regester.com.

QUEST DENTAL KATHERINE GRANT COLLIER, DDS

3BR, 2.5BA house, totally renov’d, w/screened porch, fenced yd, prkng, walk to Homewood/

Only

left!

RCA 500W receiver, 6-spkr surround sound, 6-disc standalone CD player, from early 2000s, works great. wreisig@verizon.net. Christian Dior Norwegian blue fox fur coat, medium size, full-length, great holiday gift. $1,200. 443-824-2198. Pair of exterior French doors, new, white, 8 ft x 3 ft, made of Auralast wood, w/15 double E-glass panels and double locks. $750/both. 443-768-4751. Towson spa eyebrow waxing certificate. Best offer. 410-337-9877 or i1__@hotmail.com. 3-step ladder, chair, computer, microwave, printer, beach chairs (2), stool, reciprocating saw, tripods, digital piano. 410-455-5858 or iricse.its@verizon.net. Conn alto saxophone, mint condition. $650/ best offer. 410-488-1886. Ikea “Bjursta” dining table w/2 pullout leaves, seats 4-8, $100; Ikea white desk, $15; HP Deskjet D1341 printer and color cartridge, $20. willy.dely@gmail.com.

SERVICES/ITEMS OFFERED OR WANTED Lost: Silver, well-worn, very precious wedding

410 .764.7776 www.BrooksManagementCompany.com

Tuscany-Canterbury Apartment

Beautiful 1920s Top Floor, light-filled with windows on 3 sides, 3BD-2BA; den; DR; FP; eat-in modern kitchen, CAC, W/D. Walk to Homewood, shops, shuttles. Available January 1. $2400/mo

kateboliver@gmail.com

Found: 2700 blk St Paul/Charles Village, women’s brown “designer” duffle bag w/athletic shoes, white T-shirt and quilted paisley backpack. Chris, 443-570-0521. Occasional babysitter wanted for 2 toddlers in our Oakenshawe/Charles Village home, short walk to Homewood campus, experience and refs req’d, flexible. 410-243-8724. Volleyball players wanted to join a men’s volleyball club, w/coached practice sessions Saturdays in Cooley Center, Tuesday and Wednesday night league games; all levels welcome. 443-854-5193. I need 2-way carpooling to Washington DC for FRM exam on Nov 21. 617-938-7887. LCSW-C providing 1-on-1 psychotherapy, JHU-affiliated, experience w/treating depression, anxiety, sexual orientation and gender identity concerns, couples. 443-735-9283 or shane.grant.lcswc@gmail.com. Power washing, no job too small, free estimate. Donnie, 443-683-7049. Piano lessons w/experienced teacher, Peabody doctorate, all levels/ages welcome. 410-6627951. Guitar lessons w/experienced teacher, rock, jazz, classical, blues, folk, etc; learn songs, technique, theory, improv, reading, beginner through advanced; will travel. $40/hr. Joe, 410-215-0693. Need a PT job? Sell Avon. beansavonmom@ hotmail.com. Newly resettled in Baltimore (from NYC), looking for any info on flamenco classes/ events, must be accessible to public transportation. missmasala@gmail.com. Looking for CS partner; I will take the exam in December. wdyh_co@hotmail.com. Free ride from JHH to Fairlands Aquatic Center ($22/mo) for a lap swimming partner, 3 eves per wk. ys4cL@yahoo.com. Want to learn to play piano? Experienced teacher, master’s student at Peabody, accepting new students. $30 for 30 mins or $40 for 55 mins. 425-890-1327. Licensed landscaper available for leaf/snow removal, trash hauling, Taylor Landscaping LLC. 410-812-6090 or romilacapers@comcast.net. Shopping for holidays? Consider Avon, safe and secure. www.youravon.com/romilataylor (secure Web site). 410-615-0806. Horse boarding, 20 mins from JHU, beautiful trails from farm. $500/mo (stall board) or $250/mo (field board). 410-812-6716 or argye .hillis@gmail.com. NYC bus trip, Sat, Dec 5, depart Towson 7:30am, Fallston 7:45am, Chesapeake House 8am, arrive NYC about 10:30 am, depart 7pm. $55. 410-206-2830 or nlheyls@yahoo.com. R&D Maintenance, interior/exterior painting, grass cutting and home/deck power washing, licensed, insured, free estimates, affordable. 410-335-1284 or randy6506vfw@yahoo.com. Affordable landscaper/certified horticulturist avail to maintain existing gardens; free consultations. 410-683-7373 or grogan.family@ hotmail.com. Free: Solid oak kneehole desk, 56"W, 34"D, 30"H, in very good cond, buyer must pick up (I live in Roland Park). 410-294-6503.

PLACING ADS

Historic 1891 Elevator Secured Bldg. Brand New Units - $1250-$1300 2BD & 2 Full Baths, full size W/D, D/W, micro., carpet, CAC, free off-street pkg. 2300 N. Calvert. Central to all Hopkins locations!

band, probably lost in Outpatient Center on 11/4 or 11/5. Arlene, 410-664-6859.

Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines: • One ad per person per week. A new request must be submitted for each issue. • Ads are limited to 20 words, including phone, fax and e-mail.

• We cannot use Johns Hopkins business phone numbers or e-mail addresses. • Submissions will be condensed at the editor’s discretion. • Deadline is at noon Monday, one week prior to the edition in which the ad is to be run. • Real estate listings may be offered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.) Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attachments) to gazads@jhu.edu; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Baltimore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.

12 THE GAZETTE • November 16, 2009 N O V .

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–

3 0

Calendar B L OO D D R I V E Wed., Nov. 18, and Thurs., Nov. 19, 7:30 a.m. to 5:45 p.m.

Red Cross Homewood campus blood drive. Sponsored by Faculty, Staff and Retiree Programs. Register online at http://hrnt.jhu.edu/ fsrp/outreach/blooddrive/schedule .cfm. Glass Pavilion, Levering. HW

COLLOQUIA Tues., Nov. 17, 4:15 p.m. The Ephraim and Wilma Shaw Roseman Colloquium—“Molecular Determinants Governing Oxylipin Biosynthesis in Fatty Acid Oxygenases” with Michael Malkowski, Hauptman-Woodard Medical Research Institute. Sponsored by Chemistry. 233 Remsen. HW Wed., Nov. 18, and Thurs., Nov. 19, 9 a.m. to 6 p.m. The Fifth

Annual Lavy Colloquium—The Jewish Jesus, with various speakers. (See “In Brief,” p. 2.) Smokler Center for Jewish Life (Hillel). HW

2009 MSE Symposium wraps up Actor/director Sean Astin is the final speaker in the 2009 Milton S. Eisenhower Symposium, whose theme is ‘A Transition Between Generations in a Changing America.’ See Special Events.

Skidelsky, University of Warwick (professor emeritus). Rome Building Auditorium. SAIS Wed.,

Wed.,

“Perspectives on the Past, Present and Future of Human Spaceflight,” an Applied Physics Laboratory colloquium with Roger Launius, National Air and Space Museum. Parsons Auditorium. APL

Wed.,

Fri., Nov. 20, 5 p.m. “Emotions, Reasons and the Functional Imaging of Moral,” a Philosophy colloquium with Colin Klein, University of Illinois, Chicago. 160 Mattin Center. HW

D I S C U S S I O N S / TA L K S Mon.,

Nov.

16,

12:30

p.m.

“Challenges and Prospects of the Copenhagen Climate Change Conference,” a SAIS Global Energy and Environment Initiative discussion with Tim Wirth, president, United Nations Foundation and the Better World Fund. 500 Bernstein-Offit Building. SAIS Mon., Nov. 16, 7:30 p.m. “Winning Hearts and Minds: American Public Diplomacy in the 21st Century,” a SAIS American Foreign Policy Program panel discussion with Alec Ross, Office of the U.S. Secretary of State; Joan Mower, Voice of America; Philip Seib, University of Southern California; and Phyllis Elliott Oakley, SAIS. Co-sponsored by the Krieger School of Arts and Sciences. LL7 Bernstein-Offit Building. SAIS

“John Maynard Keynes: Return of the Master,” a SAIS European Studies Program discussion with Robert

Tues., Nov. 17, 5 p.m.

18,

12:30

p.m.

“Macroeconomic Imbalances: Neoliberal Ideas and the Global Financial Crisis: Lessons and Policy Implications,” a SAIS European Studies Program discussion with Matthias Matthijs, American University. 103 Rome Building. SAIS

Thurs., Nov. 19, 3 p.m. “The Schon Affair,” a Physics and Astronomy colloquium detailing a recent case of scientific fraud, with science and technology writer Eugenie Samuel Reich. Schafler Auditorium, Bloomberg Center. HW Fri., Nov. 20, 2 p.m.

Nov.

18,

12:30

p.m.

“Managing Ocean Resources: The Case of the Atlantic Bluefin Tuna,” a Global Energy and Environment Initiative at SAIS discussion with Steve Rody, Earthjustice. 500 Bernstein-Offit Building. SAIS Nov.

18,

12:45

p.m.

“What We Have Learned About the Inter-American System From the Recent Institutional Crisis in Honduras,” a SAIS Latin American Studies Program discussion with Joy Olson, executive director, Washington Office on Latin America. 517 Nitze Building. SAIS Mon., Nov. 30, 12:30 p.m. “Chi-

na’s Civil Nuclear Energy Plans and Their Implications,” a SAIS China Studies Program discussion with Bo Kong, director, SAIS Global Energy and Environment Initiative; and David Lampton, director, China Studies Program. 806 Rome Building. SAIS

G RA N D ROU N D S Wed., Nov. 18, noon. “Who Will

Keep the Public Healthy in 2020?” Public Health Practice grand rounds with Henry Taylor, SPH. Sponsored by the Mid-Atlantic Public Health Training Center and the Maryland Department of Health and Mental Hygiene. Live webcast available at www.jhsph .edu/maphtc/training_events/ events_calendar.html. W1214 SPH (Sheldon Hall). EB

Wed., Nov. 18, 3:30 p.m. “Meta-

Leadership in the Time of Crisis,” with Leonard Marcus, Harvard School of Public Health and the Kennedy School of Government, and faculty respondents Jonathan Links, SPH, and Michel Ibrahim, SPH. Part of the Inspiring and Training Future Public Health Leaders grand rounds lecture series, cosponsored by Health Policy and Management, the Pfizer Corp., the SPH Office of Public Health

Practice and Training, the MidAtlantic Public Health Training Center, the Mid-Atlantic Health Leadership Institute, the Maryland Public Health Association and the Maryland Association of County Health Officers. Live webcast available at www.jhsph .edu/maphtc/training_events/ events_calendar.html. W1214 SPH (Sheldon Hall). EB “Statistical Challenges in Modeling Human Fecundity,” Biostatistics grand rounds with Germaine Buck Louis and Rajeshwari Sundaram, both of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. W2030 SPH. EB

Wed., Nov. 18, 3:45 p.m.

“Update on Health Care Reform,” General Preventive Medicine fall grand rounds with Rep. John Sarbanes. Co-sponsored by the Mid-Atlantic Public Health Training Center and the Maryland Department of Health and Mental Hygiene. Live webcast available at www.jhsph .edu/maphtc/training_events/ events_calendar.html. W1214 SPH (Sheldon Hall). EB

Wed., Nov. 18, 4 p.m.

“Information Technologies for Smarter Health Care,” Health Sciences Informatics grand rounds with Joseph Jasinski, IBM Research. Co-sponsored by SoM and SPH. W1214 SPH (Sheldon Hall). EB

Fri., Nov. 20, 12:15 p.m.

I N FOR M AT I O N SESSIONS

Thurs.,

Wed., Nov. 18, 6:30 p.m. Information session for the MA in Applied Economics Program, an opportunity to discuss curriculum, submit an application and meet associate program chair Frank Weiss. RSVP online at http:// advanced.jhu.edu/rsvp/index. cfm?ContentID=1539. LL7, Washington DC Center.

19,

6:30

p.m.

Thurs.,

Nov.

19,

6:30

p.m.

Information session for the Master of Liberal Arts Program and reception. Learn about the program, submit an application and talk to associate program chair Melissa Hilbish. RSVP online at http:// advanced.jhu.edu/rsvp/index .cfm?ContentID=1621. Mason Hall. HW Thurs., Nov. 19, 7 p.m. Online information session for the MS in Environmental Sciences and Policy. Learn about the program, experience an online course, interact with current students and ask questions. RSVP online at http:// advanced.jhu.edu/rsvp/index. cfm?ContentID=1622.

L E C TURE S

“Malevich and the Dynamics of Space,” a History of Art lecture by Christina Lodder, University of St. Andrews, Scotland. Co-sponsored by History. 255 Mergenthaler. HW

Mon., Nov. 16, 4 p.m.

Mon., Nov. 16, 5:15 p.m. “Is There Such a Thing as InnerEuropean Postcolonial Studies?” a German and Romance Languages and Literatures lecture by Birgit Wagner, University of Vienna. 101A Dell House. HW Tues., Nov. 17, 5 p.m. “Spinoza’s Counterfactual Zionism,” a Leonard and Helen R. Stulman Program in Jewish Studies lecture by Warren Zev Harvey, Hebrew University, Jerusalem. Smokler Center for Jewish Life (Hillel). HW

“Rus in Urbe: Visual Pleasures in Pompeian Townhouses,” a History of Art lecture by Herica Valladares, KSAS. Banquet Room A, Charles Commons. HW

Tues., Nov. 17, 6 p.m.

Wed., Nov. 18, 7:30 a.m. Leaders & Legends series—“Building a 21st-Century Company” by Greg Lucier, president and CEO, Life Technologies. (See story, p. 2.) Sponsored by the Carey Business School. Legg Mason Tower, Harbor East. The Kempf Lectures, by Eric Bedford, Indiana University. Sponsored by Mathematics. HW

MUSIC Thurs., Nov. 19, Fri., Nov. 20, and Sat., Nov. 21, 7:30 p.m.; Sun., Nov. 22, 3 p.m. The

Peabody Opera Theatre, with the Peabody Symphony Orchestra, presents Mozart’s Cosi fan tutte, with guest stage director A. Scott Parry. $25 general admission, $15 senior citizens, $10 students with ID. For tickets, call 410-234-4800 or e-mail boxoffice@peabody.jhu .edu. Friedberg Hall. Peabody

Thurs., Nov. 19, 8 p.m. Vocal Chords a cappella group presents its fall concert. Schafler Auditorium, Bloomberg Center. HW Thurs.,

Nov.

19,

p.m.

“S.L.A.M.” hip-hop and step fall dance concert. Shriver Hall Auditorium. HW Sat., Nov. 21, 7 p.m. JHU Jazz Bands fall concert. 101 Mattin Center (SDS Room). HW Sat., Nov. 21, 8 p.m. The Allnighters a cappella group presents its fall concert. Schafler Auditorium, Bloomberg Center. HW

Hopkins Symphony Orchestra presents a chamber concert, featuring Respighi’s Ancient Airs and Dances, Suite 111, and Shostakovich’s Sinfonia for String Orchestra. Bunting-Meyerhoff Interfaith Center. HW

Sun., Nov. 22, 3 p.m.

The JHU Wind Ensemble presents its fall concert. Shriver Hall Auditorium. HW

Sun., Nov. 22, 7 p.m.

S E M I N AR S Mon., Nov. 16, noon. “At the Brink of a Great Transformation? Karl Polanyi, Political-Economic Pendulums and the Crisis Today,” a Sociology seminar with Gareth Dale, Brunel University, London. 526 Mergenthaler. HW Mon.,

Nov.

16,

1:30

p.m.

“Modeling and Simulation of Actin Polymerization in Cells,” a Biomedical Engineering seminar with Les Loew, University of Connecticut. 110 Clark (videoteleconferenced to 709 Traylor, SoM). HW Mon., Nov. 16, 4 p.m. “Superrigidity of Hyperbolic DM-Complexes,” an Analysis/PDE seminar with George Daskalopoulos, Brown University. Sponsored by Mathematics. 304 Krieger. HW

•

Wed., Nov. 18, 4:30 p.m.

“Dynamics of Complex Surface Automorphisms.” 308 Krieger.

“NIAID Intramural Research Program and Human Interferons: Structure and Function,” a Biochemistry and Molecular Biology seminar with

•

Thurs., Nov. 19, 4 p.m.

Continued on page 6

Mon., Nov. 16, 7 to 8:30 p.m.

Online information session for the MS in Bioscience Regulatory Affairs. Learn about admission requirements, curriculum design, course structure, degree requirements; participate in an online discussion or chat with faculty and the associate program chair. RSVP online at http://advanced.jhu.edu/ rsvp/index.cfm?ContentID=1619. Sponsored by Advanced Biotechnology Studies.

Nov.

Information session for the Master of Arts in Writing Program and reception. RSVP online at http:// advanced.jhu.edu/rsvp/index .cfm?ContentID=1620. Mason Hall. HW

“Dynamics of Rational Surface Automorphisms.” 304 Krieger.

Mon., Nov. 16, 4 p.m.

Calendar

Key

(Events are free and open to the public except where indicated.)

The Fifth John C. and Susan S.G. Wierman Lecture—“Houston Air Quality: A Simultaneous Examination of Multiple Pollutants” by Katherine Bennett Ensor, Rice University. Sponsored by Applied Mathematics and Statistics. 111 Mergenthaler. HW

Applied Physics Laboratory Broadway Research Building Cancer Research Building Computational Science and Engineering Building EB East Baltimore HW Homewood KSAS Krieger School of Arts and Sciences PCTB Preclinical Teaching Building

“The Baroque Tsunami” a German and Romance Languages and Literatures lecture by Gregory Lambert, Syracuse University. 101A Dell House. HW

SoM SoN SPH WBSB WSE

Thurs., Nov. 19, 4 p.m.

Thurs., Nov. 19, 5:15 p.m.

APL BRB CRB CSEB

SAIS School of Advanced

International Studies School of Medicine School of Nursing School of Public Health Wood Basic Science Building Whiting School of Engineering