AstraGinTM A Clinically Validated Natural Ingredient that Transports Significantly greater Amount of Nutrients from Blood Stream to Cells for Truly Improved Bioavailability
Presented by NuLiv Science January, 2010
AstraGinTM Makes more nutrients available to trillion cells for truly improved cellular nutrition and health •
AstraGinTM improves amino acids, glucose, vitamins absorption by 62%, 57%, and 50%.
•
AstraGinTM enhanced carbohydrate utilization and elevated cellular ATP level by 18%.
AstraGinTM’s Nutrients Absorption Model
What’s in AstraGinTM From highly purified enriched Notoginseng and Astragalus extracts using pharmaceutical grade extraction and processing technology
How AstraGinTM Works Through regulation and paralleled alteration on both the protein and mRNA expression levels of the nutrient transporter genes
Science Behind AstraGinTM In-house & 3rd parties In vitro, in vivo, and human studies
In Vitro
(Human intestinal Caco-2 cells)
Apical
Caco-2 cells, EM 4000x
Basal
In Vitro
(Human intestinal Caco-2 cells)
TM
AstraGinTM
100X
1X Con
10X
Relative SGLT1 protein levels
Relative fold
Relative fold
Relative level of SGLT1 mRNA
In Vitro
(Human intestinal Caco-2 cells) Relative folate transport protein levels
Con
TM
Con
AstraGinTM
100X
10X
1X
Relative fold
Relative fold
Relative level of folate transporter mRNA
In Vitro
Glucose and Folate absorption in Caco-2 cells Relative Glucose absorption (%) Control
AstraGinTM
100.00 High dose
141.27
Mid dose
164.16
Low dose
183.15 Relative folate absorption (%)
Control
100.00
AstraGinTM
150.00
In Vitro
Tryptophan and Arginine absorption in Caco-2 cells Relative tryptophan absorption (%) Control
AstraGinTM
100.00 High dose
142.48
Mid dose
133.47
Low dose
130.17 Relative arginine absorption (%)
Control
AstraGinTM
100.00 High dose
161.69
Mid dose
151.94
Low dose
136.97
In Vitro
(Human intestinal Caco-2 cells)
ATP level (%)
AstraGinTM enhanced carbohydrate utilization and elevated cellular ATP level by 18%
In Vivo AstraGinTM increased insulin sensitivity by 38% and decreased blood sugar level by 19% when compared to the control group TM
(min)
TM
(min)
Human Study
Glycogen (%)
AstraGinTM increased post exercise muscle glycogen level by 60% and improved recovery time and endurance threshold when compared to the control group 159.5 100
Placebo
AstraGinTM
Publication and Patent • T.C. Chang*, S.F. Huang, T.C. Yang, H.C. Lin, W.L. Chang *; The Effect of Ginsenosides on Glucose Uptake in Human Caco-2 Cells is Mediated through Altered Expression of Na+/coupled glucose transporter 1. J. Agric. Food Chem. (2007) • Taiwan patent (I271195) • Patent-pending (TW 095141624; US 20060292251, 20060293255; CN 200610090113.0, 200610090114.5)
Applications • • • • • • • •
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