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Karthikeyan and Hildreth Join Division of Molecular & Cellular Pathology The Division of Molecular & Cellular Pathology, directed by Ralph Sanderson, Ph.D., Professor, added two new faculty this year.
Eason Hildreth, Ph.D., joined the UAB
Pathology faculty as Assistant Professor, coming to us from the Medical College of South Carolina. He began his career in veterinary medicine by obtaining his DVM from North Carolina State University College of Veterinary Medicine. Hildreth then completed a small-animal rotating medicine and surgery internship with the University of Florida College of Veterinary Medicine, before moving on to a small-animal surgical residency at the Ohio State University College of Veterinary Medicine. During his residency, he completed a concurrent master of science degree evaluating the use of parathyroid hormone-related protein (PTHrP) as an in vitro bone-forming agent. After his surgical residency, Hildreth stayed at Ohio State to complete a Ph.D. that focused on evaluating the roles of PTHrP in skeletal development and the use of PTHrP as a bone-forming agent in vivo, supported by funding from an NIH-NIAMS F-32 grant and the Ohio State’s C. Glenn Barber Fund for Protein Research. During his Ph.D. studies, Hildreth developed an intense interest in the advanced imaging of bone using microCT, particularly in response to bone-forming therapies or genetic modification. This resulted in collaborations where he performed microCT analysis for multiple bone biology and cancer research laboratories. Upon completing his Ph.D. Hildreth became an associate faculty member in the Ohio State University College of Veterinary Medicine as an Instructor of Small Animal Surgical Practice. In this role, he taught bone biology, general surgery, and orthopedics within the veterinary curriculum. Starting in May 2015, he joined the laboratory of Michael Ostrowski, Ph.D., in the Comprehensive Cancer Center as a Post-Doctoral Fellow. He continued to teach within the veterinary curriculum. Hildreth’s research focus was the investigation of the role of macrophages and osteoclasts in breast
cancer bone metastasis, and transcription factors and microRNAs regulating osteoblast and osteoclast differentiation and function. In 2017, Hildreth joined Ostrowski at the Medical University of South Carolina, continuing his post-doctoral training in the Department of Biochemistry and Molecular Biology, and the Hollings Cancer Center. He received an NIH K01 Mentored Research Scientist Career Development Award in 2018, and was promoted to Research Assistant Eason Hildreth, PhD Professor. In 2019 he received the John Haddad Young Investigator Award from the American Society for Bone and Mineral Research. In his position at UAB, Hildreth will continue to focus on macrophage and osteoclast-specific targeting for the prevention and treatment of breast cancer bone metastasis and primary bone malignancies. His research uses animal models of human disease and cancer, advanced in vivo imaging, nanoparticle drug delivery, ChIP Seq, and other molecular techniques. Outside of work, he enjoys spending time with his wife Emily and their American Cocker Spaniel, Raleigh. They are looking forward to exploring all of the trails and parks in and around Birmingham. He is an avid soccer fan, and more specifically, Liverpool FC.
Mythreye Karthikeyan, Ph.D., completed her undergraduate education at the prestigious Biochemistry Honors program at Delhi University in India, followed by a master’s degree, a brief research internship, and subsequently a Ph.D. from the Department of Biology from the University of North Carolina in Chapel Hill. This rigorous graduate training in the fundamentals of chromosome segregation mechanisms using cellular and genetic tools was the gateway to a postdoctoral fellowship at Duke University, where she started her career in cancer signaling. CONTINUED NEXT PAGE
Issue 1 2020 UAB Pathology
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