2016 Department of Medicine Annual Report - University of Miami, Miller School of Medicine by University of Miami Department of Medicine

I M PAC T F U L MEDICINE

D E PA R T M E N T O F M E D I C I N E C H A I R M A N â&#x20AC;&#x2122; S R E P O R T 2 0 1 6

Table of Contents

Chairâ&#x20AC;&#x2122;s Message

Who We Are

Inclusive & Impactful

Educational Programs

6 Cardiovascular 9 Clinical Pharmacology Design, Editorial & Project 10 Endocrinology, Diabetes and Metabolism Management Consulting: 12 Gastroenterology Sabia Communications, Inc. 14 General Internal Medicine 16 Geriatrics and Palliative Medicine Published by the Chairman's Office of the 19 Cancer Treatment, Research and Education Department of Medicine of the University 20 Hematology of Miami Miller School of Medicine. 22 Medical Oncology All contents, ÂŠ2016 University of Miami. 24 Hepatology Reproduction in whole or in part without previous written permission by the editor 25 Hospital Medicine is prohibited. 26 Infectious Diseases 28 Nephrology and Hypertension 29 The Peggy and Harold Katz Family Drug Discovery Center 31 Population Health and Computational Medicine 32 Pulmonary, Allergy, Critical Care and Sleep Medicine 34 Rheumatology and Immunology

42 Philanthropy

Listing of Residents

Listing of Fellows

Division Reports

Editor: Cristina Baldor Director, Business Operations

Department Publications

through

EDUCATION RESEARCH and

SERVICE U H ea l t h | U n i v er s i t y o f M i a m i M i l l er School of Med i c i ne

Chair’s Message Welcome to the Department of Medicine at the University of Miami Miller School of Medicine. In this year’s annual report, we explore the theme of IMPACT. As a world class academic medical center we are distinctly the University of Miami, with the goal of our discoveries impacting the greater body of scientific knowledge and improving society. We see the effects of our teaching, research and service in global crises, in our local South Florida community, and in the patient sitting in our exam room and the family that worries for her. Oftentimes we find ourselves just as changed as those we serve. I invite you to learn more about who we are, what makes us special, and how we produce truly IMPACTFUL and distinctive medicine. All my best,

Roy E. Weiss, MD, PhD, FACP, FACE Professor of Medicine Kathleen and Stanley Glaser Distinguished Chair in Medicine University of Miami Miller School of Medicine

Impacting Society D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Who We Are

President Julio Frenk, MD, MPH, PhD

The University of Miami, founded in 1925, is the premier educational institution in the state of Florida. Its Leonard M. Miller School of Medicine (MSOM), founded in 1952, was the first medical school in the state and is acclaimed nationally and internationally for research, patient care, education and community service. The MSOM main campus is located within the 80-acre Miami Health District, one of the largest concentrations of medical and research facilities in the United States. The DEPARTMENT OF MEDICINE is the largest department in both the MSOM and the University of Miami. Its 350+ faculty serve over five million South Florida residents as well as complex case referrals from the Caribbean, South America and beyond. The UHealth system is the only academic medical center in South Florida. Based administratively out of the Don Soffer Clinical Research Center, the Department operates clinical practices on

campus at University of Miami Hospital, Jackson Memorial Hospital, the Miami Veterans Affairs Medical Center, Sylvester Comprehensive Cancer Center and the Diabetes Research Institute, and also serves patients and conducts research at ten satellite locations in Miami-Dade, Broward and West Palm Beach counties. In FY2016, UHealth welcomed new University of Miami President, Dr. Julio Frenk, as well as new SVP for Health Affairs and CEO of UHealth, Dr. Steven Altshuler. Dean Pascal Goldschmidt retired from his post after a decade at the helm of the Universityâ&#x20AC;&#x2122;s entire healthcare enterprise, during which he oversaw the creation of the University of Miami Health System, UHealth. After a sabbatical, Dr. Goldschmidt will continue at UHealth with special responsibilities for international medicine. Dr. Laurence Gardner, Executive Dean for Education and Policy and Chair Emeritus of the Department of Medicine, has been named interim Dean.

Department of Medicine by the Numbers

UHealth Locations

SVP for Health Affairs and CEO of UHealth, Steven Altshuler, MD

FY2016

350+ 270+ 110+ 190+ $68M $27M 800K

Faculty

Dean Pascal Goldschmidt, MD

Staff

Fellows

Residents

Clinical Revenue (9% increase) Grant Revenue (18% increase) wRVUs (12% increase)

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Inclusive & Impactful In the Department of Medicine, we are proud not only to serve one of the most diverse patient populations in the nation, but also to be comprised of faculty, staff and trainees from a multitude of backgrounds. As of March 2016, over 50% of the faculty were of Hispanic, Black/ African American, Asian, American Indian/ Alaska Native or other ethnicities. Based in the melting pot of South Florida, we serve patients in languages from Spanish to Hebrew, Creole to Chinese. The Office of Diversity and Inclusion helps bring this unique experience to the next generation of physicians. Led by Dr. Stephen Symes, Associate Professor in the Division of Infectious Diseases and Associate Dean for Diversity and Inclusion, the office works to recruit, develop and retain a diverse academic community at the Miller School of Medicine. The Office also forms mentoring relationships with local high schools, colleges, and medical students and residents. The highly structured Miami Model Summer programs, pictured here, develops promising young learners, under-represented in medicine and sciences, to be leaders in healthcare delivery and champions of health equity for the future. Department faculty also play key leadership roles in the medical school’s Women in Academic Medicine group (WIAM). Founded in 2008 and currently led by President Dr.

Lilian Abbo, Associate Professor of Clinical in the Division of Infectious Diseases, VicePresident Dr. Ivette Motola, Associate Professor of Clinical Medicine, and supported by Nanette Vega, Executive Director of Diversity and Multicultural Affairs, the group works to support the career development of women faculty and increase women’s participation in academic leadership roles, while also working to eliminate gender discrimination and harassment at all levels. WIAM held its first annual University of Miami Women and Minority Leadership and Professional Development Symposium in May 2016. The event featured UM President Dr. Julio Frenk, as well and Felicia Knaul, PhD, professor of public health sciences and Director of the Miami Institute for the Americas. The Department’s strong relationship with the Miami Veterans Affairs Medical Center continues to allow faculty to serve those who served our nation in the armed forces. Thomas M. Hooton, MD, is the Chief of Medicine at the VA and a Professor of Clinical Medicine in the Division of Infectious Diseases. Twenty-five of the Department’s faculty have appointments in the VA system, and its residents and fellows also complete VA rotations.

Above: Students in the Miami Model Summer programs, coordinated by the Office of Diversity and Inclusion

Dr. Thomas M. Hooton, Professor of Clinical Medicine in the Division of Infectious Diseases, serves as the Chief of Medicine of the Miami VA Medical Center, overseeing the provision of care for military veterans by Department faculty and trainees.

Left: Dr. Marilyn Glassberg, Professor of Clinical Medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, serves as the Vice Chair for Innovation and Diversity, overseeing efforts on behalf of the faculty of the Department of Medicine to create an inclusive atmosphere and promote faculty career development.

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Educational Programs

Stefanie Brown, MD Vice Chair for Education

Below: Drs. Joshua Lenchus and Steven Falcone with Miller School of Medicine trainees at the Florida Medical Associationâ&#x20AC;&#x2122;s annual meeting in July 2016. Students took 1st place in the research category and 1st and 3rd place in the clinical category.

The University of Miami/Jackson Health System residency program in Internal Medicine was accredited just two years after the founding of the University of Miami Miller School of Medicine (MSOM) in 1952, making it the oldest residency program in Florida. Each year the program trains nearly 200 residents, including approximately 40 residents at Holy Cross Hospital in Broward County, 30 residents in the William J. Harrington Latin American Training Program, 20 Medicine-Pediatrics residents and 10 Neurology residents. In addition to educating interns and residents, the Department also trains nearly 120 fellows in 14 specialty programs. Please see pages 40-44 for a complete listing of the residents and fellows, along with information on their prior medical training. The program is proud to host trainees from the top medical schools and residency programs in the country, and itâ&#x20AC;&#x2122;s alumni are among the most distinguished medical professionals in the United States and abroad, including many of the current faculty of the MSOM. The Department also oversees 40 interns and residents in internal medicine at Holy Cross Hospital in Broward County and nearly

30 residents at JFK Medical Center in West Palm Beach County.

RESIDENT WORKS TO ESTABLISH FIRST NEEDLE EXCHANGE IN FLORIDA Residents in the Internal Medicine program are encouraged not only to develop their clinical skills, but to take on the greater mission of the Department of Medicine by making an impact globally and in the community of South Florida. This year an outstanding resident spearheaded an effort that will make the University of Miami a pioneer in prevention of infectious diseases that disproportionately affect its population (see page 18). Governor Rick Scott signed into law the Miami-Dade Disease Elimination Act in 2016, authorizing the University of Miami to pilot the first needle exchange program in Florida. Full credit goes to resident Dr. Hansel Tookes, for shouldering the effort to move this through the state legislature. Dr. Tookes continues to work closely with the Division and its partner in the project, the Department of Public Health Sciences, to ensure its success. The Florida Department of Health and Surgeon General Dr. Celeste Philip are supportive of and closely

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Left: A research associate presents her poster at the DOM’s 2nd Annual Eugene J. Sayfie Research Day

following the initiative, which includes HIV and hepatitis C testing, linkage into care, and linkage to HIV pre-exposure prophylaxis (PrEP).

RESEARCH DAY SHOWCASES EMERGING TALENT

Held on March 10, 2016, the 2nd Annual Eugene J. Sayfie Research Day showcased FORMER CHIEF RESIDENT NAMED 160 abstract submissions from Department HEALTH MINISTER OF PERU of Medicine residents, fellows, graduate A former Chief Resident in the William J. students and research associates. Two eminent Harrington Latin American Training Program, researchers were also invited to address the Dr. Patricia Garcia, has been chosen as the campus: James R. Sowers, MD, Professor of new Health Minister for the country of Peru. Medicine at the University of Missouri, an Dr. Garcia trained as a resident at UM/ expert in the field of cellular mechanisms of Jackson before completing an infectious disease insulin action and oxidative stress in tissue, fellowship at the University of Washington in gave an engaging talk on cardiovascular Seattle. stiffness while G. Sitta Sittampalam, PhD, Dr. Garcia’s success is a testament not only Senior Advisor and Project Manager at the to her exceptional skill, but also the importance National Center for Advancing Translational of the Harrington program worldwide. Sciences, provided up-to-date information Established in 1967 and housed within the on the current programs at NCATS. In the MSOM’s International Medicine Institute, the evening the Department celebrated the program offers medical students and physicians accomplishments of five promising young from Latin America and the Caribbean scientists chosen by the panel of judges for the opportunity for placement in residency their submissions in the fields of basic, clinical, and observership programs in a variety of and public health. specialties. Below: Drs. Roy Weiss and Stefanie Brown with the 2015-2016 chief residents: Drs. Sofia Palacio, Kevin Dholaria, Conrad Macon, Archana Ramireddy, Morgan Sendzischew, Cesia Gallegos

PROGRAMS AND DIRECTORS Internal Medicine Residency Stefanie Brown, MD Vice Chair for Education Program Director Frederick K. Williams, M.D. JFK Medical Center Internal Medicine Residency Program Director Lisa Martinez, MD Holy Cross Hospital Internal Medicine Residency Program Director Toni Eyssallenne, MD, PhD Medicine-Pediatrics Residency Program Director Fellowship Directors Cardiovascular Carlos Alfonso, MD Cardiovascular – Electrophysiology Raul Mitrani, MD Cardiovascular – Interventional Alexandre Ferreira, MD Endocrinology, Diabetes and Metabolism Atil Kargi, MD Gastroenterology David Kerman, MD Geriatrics Jorge Ruiz, MD Hematology-Oncology Judith De Leo Hurley, MD Hepatology Cynthia Levy, MD Infectious Diseases Susanne Doblecki-Lewis, MD Nephrology Oliver Lenz, MD Pulmonary-Critical Care Horst Baier, MD Critical Care Miguel Cobas, MD Rheumatology Carlos Lozada, MD

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Cardiovascular Division

Jeffrey Goldberger, MD, MBA Division Chief Professor of Medicine

Below, from left to right: Cardiologists Dr. Sandra Chapparo, Dr. Carlos Alfonso and Dr. Robert Hendel, UM President Dr. Julio Frenk, Cardiovascular Chief Dr. Jeffrey Goldberger, UHealth CEO Dr. Steven Altschuler, and UHealth AVP for Medical Affairs Dr. Steven Falcone. Faculty and UM leaders gathered at a kick-off event for the American Heart Association’s 2016 Heart Walk, chaired by Dr. Falcone

The faculty of the Cardiovascular Division at the Miller School of Medicine are leaders in the disciplines of ADVANCED CARDIAC IMAGING, CARDIAC REHABILITATION, ELECTROPHYSIOLOGY, INTERVENTIONAL CARDIOLOGY, and HEART FAILURE/ TRANSPLANT. The division is also home to researchers focusing on cutting edge basic science and translational research, as well as clinicians ensuring South Florida residents have access to the latest technology through clinical trials. The faculty are dedicated to campus-wide initiatives that result in advances felt in all areas of the Medical School and the UHealth system. Several hold leadership roles outside the division in areas such as Graduate Medical Education, Executive Medicine, International Medicine, Information Technology, the Interdisciplinary Stem Cell Institute and the Miami Transplant Institute. The Division’s clinical practice serves over 10,000 patients per year through both inpatient and outpatient services at University of Miami Hospital, Jackson Memorial Hospital, the Miami Veterans Affairs Medical Center and satellite offices in Kendall, Plantation and Boca Raton. The fellowship program in cardiology and advanced fellowships in electrophysiology, interventional cardiology and heart failure/ transplant train over 25 fellows annually from the top residency programs in the United States. Next year, the division will welcome two of its graduating fellows as Assistant Professors, a testament to the quality of the training and to the creation of a learning environment in which our fellows wish to continue.

NEW CHIEF BRINGS PARADIGM-SHIFTING TREATMENT OPTIONS Dr. Jeffrey Goldberger joined the Cardiovascular Division as Chief and Professor of Medicine in November 2015. He brings with him his groundbreaking research in morphology recurrence plot (MRP) mapping of the heart, a significant new tool in the diagnosis and treatment of electrophysiological conditions. Dr. Goldberger will continue this research in collaboration with his previous institution, the Northwestern University Feinberg School of Medicine, and colleagues from both medical and engineering backgrounds. Dr. Goldberger has also established the Center for Atrial Fibrillation at the University of Miami. The Center is a paradigm-shifting approach to the treatment of a cardiac condition that will affect 25% of the population at some point in their lifetimes, and an estimated 12 million people in the United States by 2020. The multi-disciplinary, multi-specialty Center brings together leaders in electrophysiology, cardiothoracic surgery, radiology, and neurology to find precision approaches that better diagnose and treat atrial fibrillation. While the impact of Dr. Goldberger’s research is felt throughout the scientific world, incorporating this holistic approach to clinical care will make a difference closer to home by providing unparalleled care to South Florida residents. The Center for Atrial Fibrillation will be one of the only locations in the country providing MRP mapping to patients, with Dr. Goldberger’s NIH-funded clinical trial of the technology set to begin in 2016.

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DIVISION FACULTY LIST Professors of Medicine Nanette H. Bishopric, MD Simon C. Chakko, MD Eduardo J. De Marchena, MD Chunming Dong, MD Jeffrey Goldberger, MD, MBA Pascal J. Goldschmidt, MD Joshua M. Hare, MD Robert C. Hendel, MD Robert J. Myerburg, MD Alberto Interian, MD Rafael F. Sequeira, MD Professors of Clinical Medicine Maureen H. Lowery, MD

Above: New heart mapping technology showing the flow of blood within

Below: The Miami Heart Research Institute and Florida Heart Research

the heart yields clues to pinpointing the causes of atrial fibrillation

Foundation are partially funded through specialty “Stop Heart Disease” license plates made available by the Florida Department of Highway

EXPANDING SERVICES NEXT YEAR Next year, the Division anticipates welcoming two additional heart failure specialists, including a Director of Heart Failure, and plans to significantly enhance the Division’s transplant services in conjunction with the Miami Transplant Institute. The Division will also add a Director of Cardiac Imaging and a physician scientist concentrating on translational electrophysiology research to its faculty in the coming academic year.

Safety and Motor Vehicles.

The Miami Heart Research Institute (MHRI) and Florida Heart Research Foundation

awarded a $2.5 million research grant to the Department of Medicine for cardiovascular research studies over the next five years. This year, $500,000 from the MHRI has been awarded between four Division faculty members for the projects listed below:

Nanette Bishopric, MD: MEF2

Chunming Dong, MD: Decipher-

Robert Myerburg, MD: Modifier

Lina Shehadeh, PhD: Role of

Acetylation as a Target in Heart

ing the Molecular Mechanisms

Genes and Variable Expressions

Osteopontin in Cardiac Fibrosis

Failure: Implications for Transcrip-

Underlying the Effects of Cocaine

of Long-QT Syndrome

in the Aging Alport Mouse

tion Modeling

in the Cardiovascular System

SUPPORT FROM MIAMI HEART RESEARCH INSTITUTE

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Associate Professors of Medicine Martin S. Bilsker, MD Mauricio G. Cohen, MD Raul Mitrani, MD Associate Professors of Clinical Medicine Eugene J. Bauerlein, MD Sandra Chaparro, MD Claudia A. MartinezBermudez, MD Carl E. Orringer, MD Eugene J. Sayfie, MD Alan H. Schob, MD David M. Seo, MD Howard J. Willens, MD Assistant Professor of Medicine Lina Shehadeh, PhDx Juan Viles-Gonzalez, MD Assistant Professors of Clinical Medicine Carlos E. Alfonso, MD Sharon N. AndradeBucknor, MD Antonio Barquet-Leon, MD Roberto A. Miki, MD Litsa K. Lambrakos Robert B. Stang, MD

“As a clinician, the importance of RESEARCH is essential for the hope I can give to my patients with difficult or apparently refractory health conditions.”

— Eugene J. Sayfie, MD

Dr. Sayfie is an over 40-year veteran of the School of Medicine and serves as Medical Director of University of Miami Executive Health, as well as an Associate Professor in the Cardiovascular Division. The DOM’s annual “Research Day” is named in his honor.

At the we transform lives through Teaching, , and Service 8

RESEARCH

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Division of Clinical Pharmacology The Division of Clinical Pharmacology is committed to the exploration of the effects of new medications under development and the investigation of the physiology of human diseases. The Division has also specialized in Phase I studies in patients with kidney and liver disease for the past 18 years and has a proven record of conducting successful clinical research across a wide range of therapeutic areas. The Division of Clinical Pharmacology is situated within the self-contained Clinical Pharmacology Research Unit on the campus of the University of Miami’s Miller School of Medicine, which has one of the largest and most diverse patient populations in the United States. The Division of Clinical Pharmacology has four central objectives: (1) conduct original research to investigate the mechanisms of disease in humans, (2) design and conduct of Phase I research studies in patients with liver and kidney diseases, (3) support the Miller School of Medicine research infrastructure and (4) conduct a wide array of Phase 1 studies across diverse patient populations.

ATTACKING DRUG-RESISTANT SUPERBACTERIAL INFECTIONS The growing problem of hospital-acquired infections with multi-drug resistant organisms constitutes an enormous clinical challenge confronting healthcare professionals. Certain populations are especially susceptible to the complications of drug resistant infections, including the estimated 30 million Americans who have some form of liver disease. These patients are particularly vulnerable to suffering the morbidity and mortality from multi-drug resistant bacteria. This past year, the Division conducted a Phase I clinical trial of a novel antibiotic that demonstrates high effectiveness against multi-drug resistant bacteria. This study was conducted in high-risk patients with liver disease. This study was designed to evaluate the effect of liver disease on the pharmacokinetics (how the body handles a drug) and safety of this new antibiotic. The study was conducted in 24 participants with various stages of liver disease and 24 healthy control participants. The Clinical Pharmacology Research Unit measured the plasma drug concentrations in patients with liver disease versus healthy control subjects over a period of 48 hours following a single oral dose. Plasma concentration versus time data for the patients with hepatic impairment did not differ significantly compared to the healthy control group. This figure demonstrates that there is no significant difference in drug levels between healthy subjects and patients with liver disease. Administration of single doses of this antibiotic was generally well-tolerated in healthy subjects and in subjects with varying degrees of hepatic impairment. Overall, the results of this study are good news to patients suffering from liver disease, and suggest a new treatment option to fight the growing problem of infection with multi-drug resistant organisms.

Richard A. Preston, MD, MSPH, MBA Division Chief Professor of Clinical Medicine Director Clinical Pharmacology Research Unit

DIVISION FACULTY LIST Professor of Medicine Barry J. Materson, MD, MBA Professor of Clinical Medicine Richard A. Preston, MD, MSPH, MBA Research Associate Professor David Afshartous, MD

Above: Dr. Richard Preston speaks with a student at the DOM’s 2nd Annual Eugene J. Sayfie Research Day

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Division of Endocrinology, Diabetes and Metabolism

Ernesto Bernal-Mizrachi, MD Division Chief Professor of Medicine

The faculty of the Division of Endocrinology, Diabetes and Metabolism care for patients with thyroid, adrenal and pituitary diseases as well as diabetes, a condition which in recent years has reached epidemic levels. Although the prevalence of diabetes has outstripped the pace of scientific discovery and the development of therapies and preventions, the Divisionâ&#x20AC;&#x2122;s faculty have risen to the challenge through a highly collegial and interdisciplinary atmosphere. With excellent core resources for biomedical research, the combined efforts of the research and clinical programs are anticipated to drive major advances for the local community, while also solidifying its place as a national and international leader in the field.

CAMPUSWIDE INITIATIVE TO CURE DIABETES Working hand-in-hand with the Diabetes Research Institute (DRI), the worldâ&#x20AC;&#x2122;s largest and most comprehensive research center dedicated to curing diabetes, the Divisionâ&#x20AC;&#x2122;s faculty seek new avenues for treatment, prevention, and an eventual cure for diabetes.

The long-term goal of this joint research effort is to have patients with diabetes who are able to live free of daily insulin injections to control glucose levels. Research efforts focus on major interest areas such as pancreatic islet cell biology, autoimmune diabetes, type 2 diabetes and diabetes complications. With the recruitment of faculty including Alejandro Caicedo and Division Chief Ernesto Bernal-Mizrachi, research in the area of pancreatic islet biology has especially flourished. Basic researchers are also investigating islet cell regeneration, autoimmunity, and physiology or pathophysiology relevant to type 1 and type 2 diabetes. Researchers are currently trying to understand how human islets orchestrate a hormonal response that contributes to glucose homeostasis, and how the pancreatic islet fails in diabetes. The faculty use a wide range of methods to study this condition, including genetically modified mice, in vitro studies, and the examination of human pancreatic slices in vivo and human islets transplanted in the mouse eye.

Right: Sophisticated techniques are used at the University of Miami to study insulin producing cells. Drs. Alejandro Caicedo and Ernesto Bernal-Mizrachi analyze pancreatic images from human and animal models to understand the mechanisms responsible for diabetes.

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DIVISION FACULTY LIST Professors of Medicine Rodolfo Alejandro, MD Ernesto Bernal-Mizrachi, MD Ronald Goldberg, MD Gianluca Iacobellis, MD, PhD Jennifer Marks, MD Karl Muench, MD Alberto Pugliese, MD Jay Skyler, MD Jay Sosenko, MD Roy E. Weiss, MD, PhD Associate Professors Alejandro Ayala, MD Atil Kargi, MD Violet Lagari-Libhaber, DO Assistant Professors of Medicine David Baidal, MD Sabina Casula, MD Diala El-Maouche, MD Bresta Miranda-Palma, MD Maria del Pilar Solano, MD Francesco Vendrame, MD, PhD

Dr. Roy Weiss, Chairman of Medicine and Professor in the Division of Endocrinology, with Benjamin Riestra, Chief Administrative Officer of the new Lennar Foundation Medical Center. The Lennar Foundation Medical Center and Comprehensive Diabetes Center are anticipated to open in December 2016.

NEW MODEL FOR EXCEPTIONAL PATIENT CARE This complementary and diverse approach offers an ideal model to make groundbreaking discoveries that could be translated into clinical therapies. These research efforts complement the work on immunology and islet transplantation performed at the DRI, with the ultimate goal of finding new avenues to preserve insulin-producing cells and to discover novel approaches to treating diabetes. Division faculty are also dedicated to comprehensive clinical patient care and clinical research, and supported by a team of diabetes educators and dietitians providing world-class diabetes management. This collaborative effort will be expanded by the development of the University of Miami Comprehensive Diabetes Center (CDC) in December 2016, which will be based out of D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

the new state-of-the-art Lennar Foundation Medical Center on the University of Miamiâ&#x20AC;&#x2122;s Coral Gables campus. The integration of specialties at the CDC is anticipated to create a program that is the local and regional leader in a personalized medicine approach to diabetes management. The CDC will allow for collaboration between physicians in specialties including cardiology, nephrology, podiatry, and psychiatry, as well as access to ophthalmology care through Bascom Palmer Eye Institute, the #1 ranked eye hospital in the United States. This integrated, multidisciplinary method aims to better treat complex diabetes cases, accelerate the implementation of new treatment options, train future leaders in diabetes clinical care and research, and help educate the community about the prevention of diabetes and its complications.

Research Professors of Medicine, Immunology and Microbiology Luca Inverardi, MD Ricardo Pastori, PhD Research Associate Professors Manuel Blandino, PhD Alejandro Diego CaicedoVierkant, PhD Armando Mendez, PhD

Division of Gastroenterology

Maria T. Abreu, MD Division Chief Martin Kalser Chair in Gastroenterology Professor of Medicine, Microbiology and Immunology

This continues to be an exciting time for both the field of Gastroenterology and the Division of Gastroenterology. The Division continues its cutting-edge work, making a positive impact on the health of our patients and South Florida. Gastrointestinal illnesses are among the most common reason patients seek medical care. The Division specializes in areas such as INFLAMMATORY BOWEL DISEASE and MOTILITY DISORDERS, and its educational program trains 15 fellows per year.

INVESTIGATING THE RISE OF INFLAMMATORY BOWEL DISEASES The physicians and scientists of the Crohn’s and Colitis Center and The Mickey and Madeleine Arison Family Foundation Research Laboratory, both led by Division Chief Maria Abreu, want to discover the reason behind the rising incidence of inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, and make advances in the treatment of these disorders. A team led by Dr. Oriana Damas, Dr. Abreu and Associate Professor of Human Genetics & Pathology Jacob L. McCauley, PhD, are collaborating on a newly awarded National Institutes of Health

(NIH) grant to study genetics in Hispanics with IBD. While the prevalence of IBD is low in Latin America, the incidence of IBD in Hispanics in the US is rising. The study hopes to uncover why the risk of IBD rises in Hispanic immigrants and their US-born children. They will use the data generated in Hispanics as a platform to help understand what environmental and genetic risks conspire to cause IBD in all patients.

USING STEM CELLS TO HEAL INTESTINAL DAMAGE Dr. David H. Kerman, Assistant Professor of Medicine and IBD specialist, is the Principal Investigator of a clinical trial in which he and colleagues from colorectal surgery, the Crohn’s and Colitis Center, and the Interdisciplinary Stem Cell Institute (ISCI) will use mesenchymal stem cells (MSCs) to treat patients with Crohn’s disease who have developed fistulas. The study is unique in that it will use MSCs that are widely available (allogeneic) and use special endoscopic equipment, endoscopic ultrasound, to guide the injection of the cells to the exact place they need to be, one of the most difficult aspects of using MSCs for Crohn’s disease treatment. Dr. Abreu, along with colleagues in Biochemistry and Molecular Biology and Surgery obtained a multi-investigator R21 NIH Exploratory/Developmental Research Grant Award for an innovative idea that hopes to circumvent the problem of getting MSCs to the right location through nanoparticle targeting. The nanoparticle is linked to a molecule that would bind the blood vessels in the inflamed intestine — basically serving as a GPS target to get the cells to find the intestine and not get lost. Although this R21 grant is for mouse work, the hopes are that with the expertise of the ISCI the findings will be quickly translated to patients.

Left: Dr. Oriana Damas leads an NIH-funded grant to study the incidence of inflammatory bowel disease in Hispanics

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Left: A new anaerobic chamber in

DIVISION FACULTY LIST

the lab of Dr. Maria Abreu allows for MD/PhD candidate Matthew C. Phillips to isolate and experiment on bacteria in the absence of oxygen, similar to the conditions found in the human gut.

Professors of Medicine Maria T. Abreu, MD Jaime S. Barkin, MD Jeffrey B. Raskin, MD, FACP, FACG, FASGE, AGAF Associate Professors of Medicine Amar Deshpande, MD, FACG Jose Garrido, MD Baharak Moshiree, MD Afonso Ribeiro, MD Daniel Sussman, MD Assistant Professors of Medicine Oriana Damas, MD Paul Feldman, MD Roberto Fogel, MD David Kerman, MD Marcelo Larsen, MD Emory Manten, MD Howard Manten, MD Enrico Souto, MD

NON-INVASIVE METHODS TO REDUCE INFECTION Intestinal bacteria lie at the heart of not only GI illnesses but even illnesses that affect the entire body. Clostridium difficile (C. diff) is a life-threatening infection of the colon that occurs when the healthy bacteria is depleted, such as after taking antibiotics. Fecal transplants from healthy donors can restore the normal bacteria and eliminate the C. diff., but it is a cumbersome process to to identify normal donors and perform the fecal transplant through a colonoscopy. Dr. David Kerman is leading a study in which pills containing healthy colonic bacteria will be given orally to treat patients with recurrent C. diff infection. The pill therapy will provide patients a noninvasive way of delivering the needed bacteria to the colon. Fecal microbial therapy also has the possibility of helping patients with other types of systemic infections. Patients in intensive care or after organ transplantation can develop infections of very resistant bacteria in their blood stream, which are thought to come from the intestine. Dr. Kerman is collaborating D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

with Division colleague Dr. Baharak Moshiree and Dr. Lillian Abbo in the Division of Infectious Diseases to conduct a study in which immunocompromised patients will be given healthy intestinal bacteria via pills as described above to reduce the risk of infection with these aggressive organisms. Dr. Moshiree, Associate Professor of Gastroenterology and Director of the University of Miami Motility Laboratory, is the 2016 recipient of the Chester Cassel Endowed Chair in Gastroenterology. Dr. Moshireeâ&#x20AC;&#x2122;s motility program provides the most sophisticated diagnostic and treatment opportunities for patients with complex motility disorders, functional bowel disorders and esophageal disorders. She has been awarded a grant by the Cystic Fibrosis Foundation to acquire disease-specific knowledge, clinical experience and treatment methods for managing gastrointestinal illnesses, including motility disorders, in patients with Cystic Fibrosis (CF). The program seeks to develop better strategies to treat CF patients, who have experienced more gastrointestinal symptoms and diseases with the increase in life expectancy. 13

Division of General Internal Medicine The Division of General Internal Medicine is dedicated to excellence in delivery of high quality patient centered care and improving the health of our community locally, nationally and globally. Its research programs are aimed at developing and testing innovative models of team-based patient-centered care to improve health outcomes among all persons including the most vulnerable population groups. Olveen Carrasquillo, MD, MPH Division Chief, Professor of Medicine and Public Health Sciences

FIRST STATEWIDE COMMUNITY HEALTH WORKER CERTIFICATION The division partners with health systems and community based organizations to test approaches that improve population health, including leveraging new technologies and tools to maximize health outcomes in both health promotion and chronic disease management. One example is ongoing research sponsored by several NIH institutes using Community Health Workers (CHWs) in areas such as diabetes, hypertension, HIV and cancer prevention. In addition, over the last five years, our research team led a statewide multi-stakeholder group that developed formal training curricula, competencies and pathways for CHWs to obtain formal certification. This

work ultimately resulted in Florida becoming the 17th state in the United States to have a formalized process for CHW certification. Over the last 18 months, over 476 CHWs have completed their formal certification through this new pathway. With support from the Patient Centered Outcomes Research Institute last year, the Division also developed curriculum and training program for CHWs in patient-centered research. Over the last six months, over 70 CHWs have completed this new training pathway. Based on this experience, we are now developing a toolkit to be used nationally to train CHWs in research.

POPULATION HEALTH PROGRAM TRAINS PRACTITIONERS IN VALUE-BASED CARE One of most exciting and impactful clinical programs this year was the Population Health Program (PHP) under the direction of Dr. Yanisa Del Toro. As health care moves from one that is fee for service volume-based to one that is focused on delivering high quality, high value-based health care, new models of care delivery are needed that can maximize population health outcomes while promoting efficient use of health care resources. In

Right: University of Miami Community Health Worker, Orieta Fontan, provides education to a patient on controlling blood pressure as part of the Hispanic Secondary Stroke Prevention Initiative run by Dr. Olveen Carrasquillo.

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DIVISION FACULTY LIST Professor of Medicine Olveen Carrasquillo, MD, MPH Professors of Clinical Medicine Panagiota Caralis, MD, JD Laurence Gardner, MD Daniel Lichtstein, MD Alex Mechaber, MD Research Professor Kenneth Goodman, PhD

Above: Dr. Laurence Gardner, Chair Emeritus of Medicine and Professor of Clinical in the Division of General Internal Medicine, was named interim Dean of the Miller School of Medicine in June 2016.

partnership with several Medicare managed care plans, we began this new PHP in 2015. The program includes nurse practitioners, patient navigators, and a care manager working with selected primary care physicians in a team to provide structured, comprehensive patient-centered care. The care team not only ensures seamless access to all needed health care services, but also does a considerable amount of health outreach between visits to implement chronic disease management and preventive care programs and assist in areas such as adherence to medications. Population health electronic medical records dashboards are also used to ensure high quality care is being delivered to all patients in the program. Already the program has resulted in large improvements in Medicare quality metrics and considerable progress in resource utilization. Further, to meet our mission of training the next generation of physicians, we have also developed curricular enhancements in these new competencies for our internal medicine trainees and imbed our trainees in all the processes of our PHP. This provides them with real world exposure to the emerging models of primary care practice of the future. D epartmen t o f Medic in e C h air man ’s R e po r t 2016

RESEARCH OUTCOMES TRANSLATED TO PATIENT CARE QUICKLY The Division is also dedicated to translating research findings to practice, notably in Dr. Erin Marcus’s work in health communication for breast cancer screening. A common finding in a mammogram is increased breast density, which can make mammograms more difficult to interpret. How to best relay information to women on such findings has been unclear. Under a NIH grant, Dr. Marcus conducted several focus groups to explore ethnic minority women’s understanding of breast density in mammogram reports and how to more effectively communicate these findings. With input from study participants, Dr. Marcus created videos in English and Spanish explaining breast density, so that women are prepared to receive such results and make an informed decision about what steps to take. The videos have been highly successful and featured in publications such as the Miami Herald. The links are now sent to all women undergoing screening mammography at UM/Sylvester Comprehensive Cancer Center (SCCC) and are freely available on the UM/SCCC website. This successful translation of research findings to practice is an example of the importance of having such work done at academic health centers where research findings can quickly be translated to the served population.

Associate Professors of Clinical Medicine Keith Custer, MD Michael Federman, MD Mark Gelbard, MD Marco Gonzalez, MD Erin Marcus, MD, MPH Hilit Mechaber, MD Paul Mendez, MD Ross Scalese, MD Joan St. Onge, MD Frederick Williams, MD Judi Woolger, MD Research Associate Professor Chi Zhang, PhD Assistant Professors of Clinical Medicine Gauri Agarwal, MD Howard Anapol, MD Monica Broome, MD Stefanie Brown, MD Alexandra Calandriello, MD Gregory Coleman, MD Gloria Coronel-Couto, MD Yanisa Del Toro, MD Yvonne Diaz, MD Bruce Eisenberg, MD Antonia Eyssallenne, MD, PhD Alexis Federman, DO Robert Federman, MD Sherin Ghali, MD Lilliam Guzman, MD Brian Hagenlocker, MD Melanie Helfman, MD Margarita Llinas, MD Sudha Lolayekar, MD Lisa Martinez, MD Meaghan McNulty, MD, MPH Michael Mueller, MD Elizabeth Parra-Garnica, MD Carla Rabassa, MD Hector Rivera, MD Hiram Rodriguez, MD Andrea Sosa Melo, MD Maritza Suarez, MD James Trice, MD Jacobo Wajner, MD Alan Yesner, MD Amalinnette Zito, MD Research Assistant Professors Sonjia Kenya, PhD

Division of Geriatrics and Palliative Medicine The Division of Geriatrics and Palliative Medicine is dedicated to excellence in clinical, education, and research programs that promote the independence and well-being of the elderly individuals. The Division includes 23 faculty members from both direct-patient care and research backgrounds.

ENSURING SAFE TRANSITIONS OF CARE Olveen Carrasquillo, MD, MPH Interim Division Chief Professor of Medicine and Public Health Sciences

This year the Division developed the Transitional Care Program in collaboration with the Miami Jewish Health System (MJHS). Led by Dr. Jenny Drice and her team at MJHS, the project is designed to ensure a safe and effective transition of geriatric patients as they move from various levels of care. It seeks to improve communication between providers, to promote collaboration and to ensure coordination and continuity of care through MJHS and UHealth. This year, the team developed two novel tools to help guide care when patients transition from an acute hospital setting to a skilled nursing and/or rehabilitation facility. One is called the Patient Risk Assessment and Stratification Screening (PRASS). The PRASS uses readily available information to identify and target at-risk patients in need of additional resources and interventions to prevent 30-day readmission.

The team piloted the tool and showed it had excellent predictive ability to identify such patients. They then developed a patient-centered comprehensive team-based intervention and found the program resulted in significantly reduced 30-day readmission rates. The tool is now helping guide proper allocation and efficient use of resources at MJHS to improve population health outcomes. The other tool developed this year was the electronic Patient Transfer Form (ePTF). This tool allows for interoperability and electronic exchange of Electronic Health Records (EHR) through safe portals from eligible medical offices and hospitals having different EHR systems. This helps ensure that treating clinicians at all sites have the most updated patient health information at their fingertips for their geriatric patients.

EXPANDING PALLIATIVE CARE IN INPATIENT, OUTPATIENT AND HOME SETTINGS Another highly impactful program has been the Palliative Medicine program, which under the direction of Dr. Khin Zaw experienced significant growth in palliative care services this past year. In addition to increasing utilization of inpatient palliative care consultations, the Division dramatically

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DIVISION FACULTY LIST Professors of Medicine Olveen Carrasquillo, MD, MPH Silvina Levis-Dusseau, MD Guy Howard, PhD Bernard Roos, MD (Emeritus) Bruce Troen, MD (Emeritus) Michael Mintzer, MD (Emeritus) Associate Professors Evan P. Cherniack, MD Stuti Dang, MD, MPH Priyamvada Rai, PhD Jorge Ruiz, MD Carlos Perez-Stable, PhD Ramiro Verdun, PhD Maria Rose van Zuilen, PhD

expanded patient access to outpatient palliative care services. The volume of palliative care office visits doubled, and services have expanded to satellite locations including Deerfield Beach, Kendall and Plantation. In development is a new “Academic Home Hospice Team” to provide high quality palliative care services for patients who prefer receiving such care in their homes.

TRAINING THE NEXT GENERATION OF GERIATRIC AND PALLIATIVE CARE SPECIALISTS The Geriatric Medicine Fellowship, established in 1989, continues to thrive under the leadership of Dr. Jorge Ruiz, recently graduating nine fellows. The Hospice and Palliative Medicine Fellowship Program, established in 2014, has now graduated five fellows and successfully hosted an initial accreditation site visit by the Accreditation Council for Graduate Medical Education. The longitudinal curriculum for medical students spans all four years of training and culminates in a four week clerkship under the direction of Dr. Van Zullen. The name of the Geriatric Medicine clerkship was recently changed to Geriatrics and Palliative Medicine, in alignment with the evolving divisional focus and the national demands for greater training in this area. In addition to a one-week rotation on the Hospice Unit at the VA, students now participate in palliative care consults at University of Miami D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Hospital. Curricular reform is also targeting current topics such as deprescribing and safer medication use in older adults.

STUDENTS SERVING THOSE WHO SERVED Fellows played a critical role in the success of a new Care Transitions program established at the Miami Veterans Affairs Medical Center (VA) by a team of Geriatricians from the Division and VA hospitalists. Fellows participated in a daily “huddle” to review newly admitted older patients and conducted comprehensive geriatric assessment, medication reviews, discharge planning and follow-up. Several fellows contributed to a scholarly research project on the pilot phase of this program that showed a 50% reduction in 30-day readmission rates and presented this data at the Annual Scientific Meeting of the American Geriatrics Society. Under the guidance of Dr. Enrique Aguilar, this past year a group of medical students led by Joshua Jue and Stuart Sacks started an initiative – Operation: Veteran Engagement (OVE) – that reaches out to older veterans residing in the VA Community Living Center. OVE is now a 31 member student organization that organizes weekly recreational activities and musical performances. Participation in this program has led to improved student perception of the elderly and generated additional opportunities for socialization for participating veterans.

Assistant Professors Enrique Aguilar, MD Joel Danisi, MD Jenny Drice, MD Itzel Fernandez, MD Juan Carlos Palacios, MD Osvaldo Rodriguez, MD Luis Samos-Guitierrez, MD Marcio Soares, MD Khin Zaw, MD Miriam Gutt, PhD Karin Zachow, MD

“In TEACHING, we look beyond just labs and medications to the social determinants of health. Our unique clinical experience enables us to solve complex problems on a systems level.”

— Hansel Tookes, MD, MPH

Dr. Tookes is a third-year resident at University of Miami/Jackson Memorial Hospital and a graduate of the Miller School of Medicine. He spearheaded efforts to start the first needle exchange in the state of Florida.

U TEACHING

At the we transform lives through , Research and Service 18

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Cancer Treatment, Research and Education The Division of Hematology and the Division of Medical Oncology are engaged in clinical, basic and translational research and provides expert hematologic care at the Sylvester Comprehensive Cancer Center (SCCC) and at our affiliated community based clinics including Jackson Memorial Hospital, the University of Miami Hospital and the Miami Veterans Affairs Medical Center. Expert hematologic care is also provided at six community clinics in Coral Springs, Deerfield Beach, Hollywood, Kendall and Plantation, and will shortly be provided in the new Lennar Medical Center in Coral Gables. Dr. Gustavo Fernandez continues to serve in his role as Associate Chief Medical Officer at SCCC and Associate Director for Clinical Affairs and Performance Initiatives in the UM/SCCC Quality Department. Dr. Fernandez has promoted extensive process improvement and successfully implemented Lean Six Sigma and PDSA (Plan, Do, Study, Act) methods to reduce turnaround times in different treatment areas. Hematologists and oncologists continue to make outstanding contributions to the understanding of the biology of HEMATOLOGIC MALIGNANCIES, SOLID TUMORS, and BENIGN HEMATOLOGIC DISORDERS. Investigators provide patients with a wide array of treatment options through the conduct of over 150 therapeutic Phase I, II and III clinical trials. Investigators use novel agents and/or combinations, stem cell transplantation (including autologous, allogeneic and cord blood transplants), and most recently introduced state-of-the-art genetically engineered cellular therapies. The combined Hematology-Oncology Fellowship Program currently includes 16 fellows and is directed by Dr. Judith DeLeo Hurley. Dr. James Hoffman serves as the associate fellowship director for Hematology, and for his skills and dedication to trainee education has received outstanding teaching awards from both the SCCC and the Department of Medicine. Dr. Pasquale Benedetto serves as associate fellowship director for Medical Oncology. A unique breast cancer fellowship has been organized under the D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

direction of Marc Lippman, MD, a nationally recognized authority in translational research related to breast cancer. Many members of the division also participate in the training of PhD candidates in the Cancer Biology Program. Over 300 fellowship applicants apply annually for one of 5-6 highly selective slots, ensuring an outstanding cadre of trainees. The fellowship provides a myriad of opportunities for clinical and bench research as well as preparation for academic careers. Five fellows have applied for American Society of Clinical Oncology (ASCO) Young Investigator Awards, and four fellows have been accepted to the prestigious American Association for Cancer Research (AACR)/ASCO Grant Writing Workshop. Fellows have recently presented their research at numerous national forums including ASCO, AACR, Connective Tissue Oncology Society, American Society of Hematology, European Society for Medical Oncology, and the San Antonio Breast Cancer Symposium. Many fellows have gone on to prestigious careers in academia, industry and community practice. One hundred percent of last yearâ&#x20AC;&#x2122;s fellowship graduates passed oncology boards.

Below: The current cohort of Hematology/Oncology fellows continues a tradition of exceptional scholarship

Division of Hematology EXPANDING LEUKEMIA RESEARCH EFFORTS

Joseph D. Rosenblatt, MD Division Chief Professor of Medicine, Microbiology & Immunology William J. Harrington Chair in Hematology

Right: Identification and targeting of the Id1 protein, which is critical for leukemia cell growth

Due to the high incidence of myeloid neoplasms in South Florida, the Division of Hematology has contributed significantly to the care of leukemias in the local community and beyond. The Division has expanded clinical and translational research efforts, catalyzed by the arrival of Dr. Ronan Swords and Dr. Justin Watts, two highly regarded clinical leukemia researchers, and SCCC Director Dr. Stephen Nimer, a nationally regarded expert on the biology, pathogenesis and treatment of leukemia and myelodysplastic syndrome. The Leukemia Program has a broad portfolio of Phase I /II trials, testing the latest and most exciting first in class therapies, including participation in pivotal clinical trials of isocitrate dehydrogenase (IDH) inhibitors in myeloid malignancies. Investigators have also opened three novel investigator initiated trials directly linked to SCCC and basic science efforts in epigenetics and developmental therapeutics, including those of Ramin Shieketar Ph.D. and Arthur Zelent, Ph.D., and has opened an array of Phase I clinical trials and has been the lead regional enroller into such trials. Through collaborations with Dr. Tan Ince in the Department of Pathology

an active leukemia tissue bank has been established with over 100 samples with full annotation and clinical information, which has reliably grown primary leukemic cell lines from patient samples. Currently under development is a live tumor cell bank for acute leukemia which will provide a resource that exists nowhere else. Division researchers have optimized a personalized approach to treating patients with acute leukemias through use of a novel ex vivo drug sensitivity platform, allowing selection of individualized drug therapies based on next generation sequencing and/or sensitivity in vitro. The notoriety generated by the Leukemia Program in the form of publications, grants, and exposure at national meetings have dramatically increased the leukemia referral base. Dr. Swords has pioneered a novel approach to leukemic therapy using a first in class NEDD8 activating enzyme inhibitor in patients with acute myeloid leukemia (AML) and myeloid dysplastic syndromes in a landmark Phase I study recently published in the British Journal of Hematology.

INTRODUCTION OF GENETICALLYENGINEERED CELLULAR THERAPY AND EXPANSION OF THE STEM CELL PROGRAM The Stem Cell Transplant Program, under the leadership of Dr. Krishna Komanduri, has grown from 48 transplants in 2009 to over 200 projected for 2016. During the past year, Dr. Lazaros Lekakis and Dr. Komanduri have introduced the first adoptive chimeric antigen receptor-T cell (CAR-T) trials in the region, involving genetically engineered T-cells designed to attack lymphoma and/or acute lymphoblastic leukemia cells. The first two such trials are already underway and actively enrolling patients. Several dramatic responses have been observed in patients who have failed standard therapies, including stem cell transplantation. Dr. Komanduriâ&#x20AC;&#x2122;s preeminence in the field of stem cell transplantation was recently recognized with his election as the President Elect of the American Society of Bone Marrow Transplantation. U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

DIVISION FACULTY LIST Professors of Medicine Yeon Soong Ahn, MD John Byrnes, MD Krishna Komanduri, MD Izidore Lossos, MD Stephen Nimer, MD Joseph D. Rosenblatt, MD Associate Professors Donald Temple, MD Associate Professors of Clinical Medicine Amer Beitinjaneh, MD Mark Goodman, MD Juan Ramos, MD Jonathan Schatz, MD

Above: Dr. Yeon Ahn of the Division of Hematology, an over 40 year veteran of the Miller School of Medicine.

The laboratory of Dr. Nimer continues to make landmark observations in the study of leukemia and other hematologic malignancies. These include important studies on the regulation of signaling in t(8;21) AML, and ongoing study of the epigenetic regulator arginine methyltransferase PRMT5 and its role in normal and malignant hematopoesis. Recent research by Dr. Nimer’s laboratory has identified the potential role for PARP inhibitors currently used only for ovarian and breast cancer as a new treatment option for a subset of patients with AML. In partnership with other investigators at the University of Miami, the Hussman Institute of Human Genomics, Dr. Nimer and his colleagues are identifying potential inhibitors of PRMT5 for clinical use through high throughput screening.

JOINING FORCES AGAINST AMYLOIDOSIS Under the leadership of Dr. James Hoffman, the Division expanded clinical and research efforts in the area of plasma cell malignancies and amyloidosis. Through Dr. Hoffman’s efforts, SCCC was accepted to join the Amyloidosis Research Consortium’s Collaborative Network. Dr. Hoffman has launched investigator-initiated protocols D epartmen t o f Medic in e C h air man ’s R e po r t 2016

funded by ERASE AMY, a philanthropic group dedicated to the funding amyloid research, focused on screening carpal tunnel syndrome patients for evidence of occult light chain and TTR amyloidosis. Other clinical trials and novel screening programs have identified patients with occult amyloidosis that can be treated early in an effort to forestall more serious cardiac or visceral disease.

NEW FACULTY IN THE DIVISION The Division continues to recruit outstanding new scientific and clinical talent to augment growing programs. New faculty arrivals include Dr. Alvaro Alencar, an outstanding community based hematologist/oncologist with specialized expertise in the treatment of lymphoid and other hematologic malignancies. Lymphoma efforts have been further augmented in the past year through the recruitment of Marzenna Blonska, Ph.D., an outstanding researcher on NF kappa B regulation in lymphoma and mechanisms of lymphoma spread into the central nervous system. The Stem Cell Program has recruited Drs. Amer Beitinjaneh from the University of Virginia, and Antonio Jimenez from Rush University in Chicago, both nationally recognized young investigators in the area of stem cell transplantation.

Assistant Professors Marzenna Blonska, PhD Ronan Swords, MD, PhD Justin Watts, MD Assistant Professors of Clinical Medicine Ney Alves, MD Sharhabil Ammus, MD Roberto Cano, MD Deborah Glick, MD Thomas Harrington, MD James Hoffman, MD Antonio Jimenez, MD Lazaros Lekakis, MD Denise Pereira, MD Alexandra Stefanovic, MD Research Professors Arthur Zelent, PhD Research Associate Professors Wenche Jy, PhD Seung-Uon Shin, PhD Ramiro Verdum, PhD Eric Wieder, PhD Research Assistant Professors Cara Benjamin, PhD Xiaoyu Jiang, PhD JonaYe Xu, PhD Yu Zhang, PhD

Division of Medical Oncology PRECISELY TARGETED GENETIC AND IMMUNOLOGICAL THERAPIES

Joseph D. Rosenblatt, MD Interim Division Chief Professor of Medicine, Microbiology & Immunology William J. Harrington Chair in Hematology

Right: Drs. Breelyn Wilky and Jonathan Trent of the Division of of Medical Oncology, leaders of the treatment of sarcomas

Investigators in the Division of Medical Oncology continue to explore novel cancer treatment strategies through an expanding portfolio of clinical trials. Dr. Jaime Merchan, Director of the Phase I Treatment Program, oversees over 20 Phase I clinical trials. The Phase I portfolio has grown rapidly and trains fellows for careers in developmental therapeutics and drug development. Dr. Merchan’s own laboratory has pioneered the first-in-man use of oncolytic viruses in the treatment of renal cell carcinoma. The SCCC joined the NCI-MATCH (Molecular Analysis for Therapy Choice) study and has been an active participant in the QUILT (Quantitated Integrated Lifelong Trial) initiative of the National Immunotherapy Coalition Moonshot 2020 Program. This program incorporates genomic and proteomic analysis, and offers multiple Phase I/II therapeutic arms using a combination of targeted therapies and novel immunotherapies. Patients’ tissues are submitted for molecular profiling and patients have been registered for treatment in a variety of trials, allowing provisions of stateof-the-art care for actionable mutations. Local residents can also participated in the DePICT study, which allows tissue analysis and

sequencing as well as stratification of patients for molecular targeting. The program has already enrolled patients with bone and soft tissue cancers, breast cancer, colorectal cancer, oncologic cancers, hematologic malignancies, gastrointestinal and pancreatic malignancies and thoracic cancers. Dr. Jonathan Trent, together with colleague Dr. Brian Slomovitz in gynecologic oncology, has helped develop a thriving new program in the provision of precision medicine. This effort allows targeting of each individual’s cancer based on next generation sequencing genomics and/or proteomics. A Molecular Tumor Board inaugurated its first meetings in May 2016 and a variety of patients, including patients with rare malignancies, have had unique targetable mutations identified, enabling the provision individualized therapy. In addition, the initiative has incorporated in vitro high throughput drug screening through a liaison with the Center for Therapeutic Innovation under the leadership of Dr. Claes Wahlestedt. Together with colleagues in the Division of Hematology and the Stem Cell Transplant Program, the Division has also introduced genetically engineered T cell therapy protocols targeting several solid tumors. These include trials using genetically engineered T cell receptors targeting the NY-ESO1 tumor antigen in lung cancer (Dr. Raja Mudad) and sarcoma (Dr. Breelyn Wilky), and alphafetoprotein in hepatoma (Dr. Lynn Feun). These trials in human gene therapy provide unique clinical options to patients with refractory solid tumors. Dr. Joseph Rosenblatt, Chief of the Division of Hematology and the Division of Medical Oncology, and his colleagues have pioneered the study of suppression of antitumor response by B regulatory cells. Using mouse models for breast cancer, Dr. Rosenblatt’s laboratory was among the first to recognize the potential inhibitory activity of a subset of tumor infiltrating B cells on the antitumor immune response. B regulatory activity has since come to be increasingly recognized as a source of U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

immune suppression of the antitumor response in a wide variety of hematologic as well as solid tumor malignancies.

MAJOR ADVANCES AND EXPANDED OFFERINGS FOR WOMEN WITH CANCER Drs. Marc Lippman and Doraya El-Ashry have conducted groundbreaking research on the potential role of cancer-associated fibroblasts in promoting metastatic breast cancer. Drs. Breelyn Wilky and Jonathan Trent have pioneered use of small molecular IDH1 inhibitors to suppress tumorigenic activity in human chondrosarcoma cells, a novel approach in a difficult to treat tumor. Joyce Slingerland, M.D., continues to explore interactions between adipocytes and breast cancer cells resulting in inflammation that drives malignant progression, and continues to identify key links between obesity and progression of breast cancer. The Hollywood breast cancer group, under the leadership of Dr. Alejandra Perez and associates Drs. Carmen Calfa and Aruna

Below: Felicia Knaul, PhD, Professor in the Department of Public Health Sciences and Director of the Miami Institute for the Americas, with the physicians of the groundbreaking SCCC Broward Breast Oncology Group at the Susan G. Koman Race for the Cure in October 2015. Left to Right: Drs. Alejandra Perez, Carmen Calfa, Felicia Knaul and Aruna Mani.

Mani, has introduced multidisciplinary breast cancer treatment including dedicated nursing, nutrition, acupuncture, psychology, exercise sociology and physical therapy, as well as robust research activity. Community doctors meet with SCCC experts at weekly interdisciplinary breast conferences in order to develop ideal treatment plans and access innovative clinical trials. Patients can attend interdisciplinary clinics in which they can see medical oncologists, surgeons, and/or radiation oncologists concurrently, which improves communication and coordinated provision of complicated care. The group has also initiated a series of educational physician-led support group activities benefiting our patients. Patients in Broward County now have more opportunities to receive individualized treatment while benefiting from a strong academic breast cancer program with the opening of a community-based breast cancer practice at the SCCC Plantation satellite office. Dr. Judith DeLeo Hurley continues landmark studies regarding genetic breast and ovarian cancer susceptibility in in Bahamian women and women of Afro-Caribbean origin. Her identification of novel BRCA-1/2 mutations has led to a National Cancer Institute and Komen Foundation supported Caribbean Womenâ&#x20AC;&#x2122;s Cancer Initiative.

DIVISION FACULTY LIST Professors of Medicine Bach Ardalan, MD Pasquale Benedetto, MD Lynn Feun, MD Marc Lippman, MD Stephen Richman, MD Joseph D. Rosenblatt, MD Joyce Slingerland, MD Jonathan Trent, MD, PhD Professors of Clinical Medicine Judith DeLeo, MD Mohammad Jahanzeb, MD Charles Vogel, MD Associate Professors Ram Agarwal, MD Dorraya El-Ashry, PhD Merchan, Jaime, MD Abdul Mian, PhD Rakesh Singal, MD Associate Professors of Clinical Medicine Chukwuemeka Ikpeazu,MD Alejandra Perez, M.D. Catherine Welsh, MD Assistant Professors Nicolas Acquavella, MD Breelyn Wilky, MD Assistant Professors of Clinical Medicine Timothy Aliff, MD Carmen Calfa, MD Gustavo Fernandez, MD Reshma Mahtani, DO Aruna Mani, MD Raja Mudad, MD Lawrence Negret, MD Agustin Pimentel, MD Maria Restrepo, MD Pearl Seo, MD Frances Valdes-Albini, MD Steven Weiss, MD Israel Wiznitzer, MD Research Professors Niramol Savaraj, MD Research Associate Professors Priyamvada Rai, PhD

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Division of Hepatology The Division of Hepatology is active in all critical aspects of care for adult patients with liver disease. Clinicians work diligently to evaluate and care for patients undergoing liver transplantation, while skilled researches investigate cutting edge therapies that dramatically impact treatment options for patients. Paul Martin, MD Division Chief Professor of Medicine

DIVISION FACULTY LIST Professors of Medicine Lennox J. Jeffers, MD Paul Martin, MD Christopher B. O’Brien, MD Eugene R. Schiff, MD Associate Professors Cynthia Levy, MD Assistant Professors Leopoldo B. Arosemena, MD Kaylan R. Bhamidimarri, MD, MPH Patricia D. Jones, MD, MSCR Maria D. Hernandez, MD Eric F. Martin, MD

Since joining the University of Miami in August 2015, Dr. Jones has analyzed the survival time in patients diagnosed with HCC at Sylvester Comprehensive Cancer Center, University of Miami Hospital and Jackson Memorial Hospital, and found significant differences in survival by race. This research was presented at Digestive Disease Week 2016 and featured on the NBC National News REVEALING STARKLY DIFFERENT website in an article entitled, “Study Finds OUTCOMES BY RACE Blacks More Likely to Die From Liver Cancer.” Coming on the heels of significant advances Dr. Jones is currently analyzing the made in the treatment of liver disease in the outcomes of HCC in the state of Florida and last several years, the recruitment of Dr. will be analyzing institutional practices on Patricia Jones to the faculty has resulted in a screening high risk patients for hepatitis B as major expansion of activity in tackling one of well as HCC. She was awarded the Jay Weiss the next important challenges, hepatocellular Institute for Health Equity Pilot Grant through carcinoma (HCC). With effective therapies for Sylvester Comprehensive Cancer Center and hepatitis C and with vaccination reducing the in collaboration with the Disparities and burden of hepatitis B in the United States, the Community Outreach Core will be conducting major therapeutic challenge in liver disease focus groups of Blacks born in the US and will be the prevention and treatment of NonHaiti to understand perceptions of hepatitis B, alcoholic fatty liver disease (NAFLD). In chronic liver disease and HCC. addition to changing causes of cirrhosis, HCC The Division anticipates this work will is the other major complication of liver disease enable the delivery of personalized care to and is now the tumor with the greatest increase vulnerable populations and impact liver cancer in frequency in the United States. outcomes both by preventing cancer from developing and improving the treatments Below: Dr. Patricia Jones analyzes disparities in outcomes for available for those who develop cancer. hepatocellular carcinoma patients

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Division of Hospital Medicine The Division of Hospital Medicine’s faculty serve as primary care physicians when patients are admitted to University of Miami Hospital (UMH), Jackson Memorial Hospital (JMH) and the Miami Veterans Affairs Medical Center (VA), coordinating with specialists to prepare for a patient’s safe discharge and superior outcomes after their stay. The Division is heavily involved with resident education and focuses research efforts in quality improvement and patient safety, medical education and perioperative medicine. Members of its faculty serve as the President of the Medical Staff at JMH and the Chairman of the Pharmacy and Therapeutics committee at UMH.

INNOVATIVE CURRICULUMS FOR RESIDENTS

Dr. Joshua Lenchus has created a novel curriculum to teach both internal medicine and other specialty residents how to safely perform procedures at the bedside. Dr. Lenchus has received over $2 million in funding for his research in this area, receiving numerous local and national awards and enabling him to travel the country to export his model of safe bedside ultrasound-guided procedures. His innovations have resulted in improved clinical outcomes, decreased complications and cost savings. Hospitalists at the VA use the renowned VA quality and safety programs to engage internal medicine residents to create healthcare HELPING ENSURE SUCCESSFUL interventions that decrease improve healthcare SURGICAL OUTCOMES costs while improving clinical outcomes. Dr. Steven Cohn, a world class thought leader Residents present their findings to the VA in the care of the surgical patients with medical leadership during their training. illnesses, has created a curriculum to teach Dr. Jessica Zuleta serves as Site Director of internal medicine residents how to care for the Internal Medicine Residency at UMH, and patients at high risk for adverse perioperative Dr. Rene Parraga-Montilla is leading a change outcomes. Residents apply the latest guidelines, in medical student education by implementing some of which Dr. Cohn co-authored, in order a checklist filled out by faculty to track the to gauge the risk of complications such as educational interventions being experienced perioperative heart attack, respiratory failure, by each medical student, then tracking long and hospital acquired blood clots, then how to term outcomes of student satisfaction and mitigate this risk in order to help safely guide performance. patients through the surgical experience.

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Efren Manjarrez, MD Division Chief Associate Professor of Clinical Medicine

DIVISION FACULTY LIST Professors of Medicine Steven Cohn, MD Barry Materson, MD, MBA Associate Professor Joshua Lenchus, DO, RPH Associate Professor of Clinical Medicine Efren Manjarrez, MD Assistant Professors Syeda Uzma Abbas, MD, MPH Alan Briones, MD Tanya Clarke, MD Jorge Florindez, MD German Giese, MD Matthew Imm, MD Shreevinaya Menon, DO Deepak Mummidavarapu, MD Rene Parraga-Montilla, MD Aldo Pavon Canseco, MD Sarahi Rodriguez-Perez, MD Jessica Zuleta, MD

Division of Infectious Diseases

Mario Stevenson, PhD Division Chief Professor of Medicine

The Division of Infectious Diseases specializes in the research and clinical management of viral infections, particularly HIV-1 and hepatitis C. The faculty serve in leadership roles in a variety of MSOM and UHealth programs that enhance and coordinate AIDSrelated research activities, including the UM AIDS Institute and the UM Center for AIDS Research (CFAR), one of only 20 CFARs in the country and the only center in Florida. In response to growing concerns about Zika virus in 2016, the Division also coordinated a rapid response to help prevent infections in South Florida.

RESEARCH UNIT OFFERS EXPANDED ACCESS TO NOVEL THERAPIES In December 2015, the Division opened the Infectious Disease Research Unit at Jackson Memorial Hospital (JMH), a newly dedicated space for comprehensive human research on HIV/AIDS that will help advance state-funded efforts to develop a vaccine and cure for the disease. The unit’s location directly adjacent to JMH’s HIV clinic allows seamless recruitment of individuals for research studies. Florida and Miami top the nation in HIV infections and new cases, especially with regard to ethnic, racial and sexual minorities and substance users, making the clinic an important venue for discovering treatments that help eradicate the disease on a global level.

COMPREHENSIVE HIV PREVENTION PLAN Clinical and research initiatives within the Division aim to reduce new HIV infections, increase access to HIV care and improve health outcomes in people living with HIV/AIDS, reduce HIV related disparities and health inequities and achieve a more coordinated response to HIV epidemic in South Florida. Members of the Division have worked closely with the Florida Department of Health, community-based agencies, local and state government, and clinical and behavioral/ social science investigators to advance the latest therapeutic, biomedical and behavioral strategies to curtail the epidemic. The Division provided critical support to the Florida Department of Health’s MiamiDade County Enhanced Comprehensive HIV Prevention Plan, and has led studies funded by the CDC, NIDA and NIMH that focus on retention in care strategies for patients who are out of care, hospitalized, and/or with detectable viral load. The Division also supported the implementation of Miami as a new southern site in the NIH-funded Women’s Interagency HIV Study.

HIV PRE-EXPOSURE PROPHYLAXIS AND RAPID RESPONSE The Division of Infectious Diseases recently completed a multi-center HIV PrEP trial. The effort in Miami was performed at the Miami

Right: Faculty gather to celebrate the opening of a new Infectious Disease research unit at Jackson Memorial Hospital

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DIVISION FACULTY LIST

Above: Researcher Mark Sharkey, PhD, worked alongside Dr. Rafael Campos and Division Chief Mario Stevenson to

DEVELOPING RAPID ZIKA VIRUS DETECTION

In response to the evolving Zika epidemic in Central and South America and the Caribbean, ID division investigators Drs. Mark Sharkey Department of Health’s sexually transmitted and Rafael Campo, together with Division disease (STD) clinic. This partnership is now chief Dr. Mario Stevenson, have developed an extending into a clinical effort with a planned assay for rapid detection of the virus. Current PrEP clinic at the Miami DoH overseen by Dr. detection methodologies are based on either Susanne Doblecki-Lewis. antibody detection or real-time PCR technology. Over the past six months, working with the The former does not reliably differentiate DoH and South Florida AIDS Network (SFAN), between Zika and clinically similar infections Dr. Allan Rodriguez and the Adult HIV Clinic (e.g. dengue, chikungunya), and the latter team has piloted a new “Rapid Response” effort. is expensive and available only in central The goal of this effort is when an individual laboratories far from where infections are seen at the STD clinic was found to be HIV occurring. The new assay relies on conventional, positive that they were accompanied into the widely available PCR machines and inexpensive HIV clinic where they received confirmatory reagents and detection methods making it testing and begun on antiretroviral therapy cost-effective and deployable throughout the within seven days. The State has shown a great affected region. The assay will shortly begin interest in this effort and will be expanding this the FDA validation process. Even more exciting into other counties and venues of testing. is the fact that the underlying technology is easily adaptable for other diagnostic processes Below: Faculty participate in panel discussion during the (e.g. antiretroviral resistance to HIV) and such University of Miami’s forum on the Zika virus in March 2016. assays are also under development. develop rapid Zika virus detection

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Professors of Medicine Gio Baracco, MD Rafael Campo, MD Jose Castro, MD Gordon Dickinson, MD Luis Espinoza, MD Margaret Fischl, MD Dushyantha Jayaweera, MD Michael Kolber, MD Michele Morris, MD Allan Rodriguez, MD Mario Stevenson, PhD Associate Professors Lilian Abbo, MD Maria Alcaide, MD Catherine Boulanger, MD Susanne Doblecki-Lewis, MD Paola Lichtenberger, MD Isabella Rosa-Cunha, MD Stephen Symes, MD Assistant Professors Jose Camargo, MD Hector Bolivar, MD Antoine Salloum, MD Jacques Simkins-Cohen, MD Research Assistant Professor Mark Sharkey, PhD

Division of Nephrology and Hypertension

Oliver Lenz, MD, MBA Interim Division Chief Professor of Clinical Medicine

Providing outstanding clinical care remains one of the Division of Nephrology and Hypertension’s core commitments. The faculty see patients at facilities on campus, at satellite locations, and in community-based dialysis clinics. Under the leadership of nephrologists serving as medical directors, some 400 outpatient dialysis patients received their care in the Nocturnal Dialysis Program, through home-based treatment options, and units that achieved the coveted 4 and 5-star rating from the Centers for Medicare & Medicaid Services.

CARING FOR SOUTH FLORIDA PATIENTS IN NEED OF TRANSPLANT DIVISION FACULTY LIST Professors of Medicine Alessia Fornoni, MD, PhD David Roth, MD Leopoldo Raij, MD Professors of Clinical Medicine Gabriel Contreras, MD, MPH Oliver Lenz, MD, MBA Kupin Warren, MD Loay Salman, MD Associate Professors of Clinical Medicine Jorge Diego, MD Dollie Green, MD Giselle Guerra, MD Ali Nayer, MD Ivonne Schulman, MD Assistant Professors of Clinical Medicine Adela Mattiazzi, MD Jair Munoz Mendoza, MD Fernando Pedraza, MD Marco Ladino Avellaneda, MD

Through the auspices of the Miami Transplant Institute, nephrologists work with patients who are difficult to transplant because they have developed antibodies against many potential donors, and match families with members willing to donate a kidney but unable to match within the family.

EDUCATING THE PHYSICIAN LEADERS OF TOMORROW Dr. Warren Kupin, Director of the nephrology course for medical students, has repeatedly won accolades for his outstanding teaching. This year, he was one of 18 outstanding Miller School of Medicine instructors honored with the prestigious Paff Teaching Award. Dr. Kupin was recognized for being an outstanding

Below: Dr. David Roth holds a “Facebook Live” session with

role model and a teacher who uses humor to engage students. The nephrology fellowship training program remains the largest program in South Florida and attracts internal medicine graduates from across the country.

TACKLING HEPATITIS C IN PATIENTS WITH CHRONIC ILLNESS Dr. David Roth and his colleagues published a landmark study in the journal Lancet that revolutionizes the care for the estimated 17 million people worldwide who are infected with hepatitis C virus and also suffer from chronic kidney disease. In addition to being an important trigger for liver disease, Hepatitis C also causes a progressive form of kidney disease that leads to kidney failure, necessitating dialysis or transplantation. Moreover, patients living with hepatitis C have a diminished life expectancy on dialysis and after transplantation compared to those free of hepatitis C. Until now, the treatment of patients with advanced kidney disease suffering from hepatitis C was unsatisfactory. Existing medications had a high rate of side effects, a limited cure rate, could not be safely used after transplantation. New medications with better outcomes had not been tested in patients with kidney disease. The “C-SURFER trial” published by Dr. Roth and colleagues demonstrates for the first time that patients with advanced chronic kidney disease can be successfully treated with a combination of grazoprevir and elbasvir, leading to a success rate approaching 99%.

the National Kidney Foundation

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The Peggy and Harold Katz Family Drug Discovery Center The generosity of the Peggy and Harold Katz Family has helped establish the Peggy and Harold Katz Family Drug Discovery Center (the Katz Center), where faculty contribute to groundbreaking research driven by the commitment to improve the lives of patients affected by kidney disease and its related complications.

COLLABORATIONS THAT BENEFIT STUDENTS AND PATIENTS The Katz family has supported and continues to support the career development of several junior investigators from the Division of Nephrology and Endocrinology in the Department of Medicine, as well as investigators from the Departments of Urology, Surgery, Radiation Oncology, Pediatrics, Pathology, Pharmacology, Cell Biology, and Biochemistry. The Katz Center provides an environment for students, residents, fellows and faculty to cultivate collaborative and interdisciplinary relationships both within the Miller School of Medicine and with the School of Biomedical Engineering, the Miami Project to Cure Paralysis, the Diabetes Research Institute and the Miami Transplant Institute. The Katz Center fosters a learning environment for volunteers that are eager to learn the fundamentals of basic science, translational medicine and clinical research by providing mentoring of the highest quality. Faculty and staff at the Katz Center have received invitations to present Continuing Medical Education lectures in more than 20 different academic institutions worldwide during this past year. In addition, several oral and poster presentations at significant national and international scientific meetings such as the American Society of Nephrology (ASN) and the International Society of Nephrology were awardedreceived awards. During FY2016, faculty, post doctoral and graduate students working with the Katz Center produced over 17 peer-reviewed publications on covering a broad range of clinical and research topics D epartmen t o f Medic in e C h air man ’s R e po r t 2016

in nephrology, cardiovascular disease and pediatrics. Two recent graduate students have gone on to secure post-doctoral positions at elite institutions – Yale University and the University of Pennsylvania. One graduate student was awarded outstanding poster presentation at the International Podocyte Meeting in Israel, and a post-doctoral researcher was accepted into the esteemed ASN Kidney Tutored Research and Education for Kidney Students (TREKS) Program. Katz Center research was also awarded highest merits at the University of Miami Department of Medicine’s 2nd Annual Eugene Sayfie Research Day. Faculty and student research is supported through the National Institutes of Health (NIH), American Heart Association, American Diabetes Association, the UM Center for AIDS Research, the UM Scientific Awards Committee, as well as industrial partners including Hoffman La-Roche and Boehringer Ingelheim. The Katz Center has also successfully served as a hub for industry-academia collaborations, an effort that has recently lead to the identification of two compounds for rare kidney diseases that will be moving forward into clinical applications in 2017. Intellectual property developed at the Katz Ccenter for the cure of patients affected by kidney disease was successfully licensed this year to Variant Pharmaceutical. The Katz Center focus areas include the implementation and execution of both investigator initiated/NIH sponsored and industry sponsored clinical studies to study the natural history of several kidney diseases and to test novel antiproteinuric agents. Moving forward, the Katz Center will continue to make an impact by matching science with innovation and patients’ motivation to find a cure for kidney diseases and its related complications.

Alessia Fornoni, MD, PhD Director Professor of Medicine

DIVISION FACULTY LIST Research Associate Professors Christian Faul, PhD Sandra Merscher, PhD Associate Professor of Clinical Medicine Ali Nayer, MD

AFFILIATED FACULTY LIST Professor of Surgery George W. Burke III, MD Director, Division of Kidney and Pancreas Transplantation Professor of Medicine Alessia Fornoni, MD, PhD Director Leopoldo Raij, MD Chief, Nephrology-Hypertension Section, Miami Veterans Affairs Medical Center Vice Chair, Vascular Biology Institute Vice Chair, Scientific Advisory Committee Professors of Clinical Medicine Loay Salman, MD Director, Interventional Nephrology Gabriel Contreras MD Professors of Pathology Laura Barisoni MD Division Chief, Renal Pathology Service David Thomas MD Director, Anatomic Pathology Outreach Service Assistant Professors of Radiation Oncology Youssef Zeidan, MD, PhD Associate Professor of Surgery Roberto Vasquez-Padron, PhD

“In the service of others, we share our time, knowledge and compassion with those who feel forgotten. Their smiles are precious gifts that remind us of the power of solidarity.”

— Ana Palacio, MD, MPH

Dr. Palacio is an Associate Professor in the Division of Population Health and Computational Medicine. She helped lead a team of UHealth physicians to provide disaster relief in Ecuador after the devastating earthquake in April 2016.

At the

U we transform lives through

Teaching, Research, and 30

SERVICE

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Division of Population Health and Computational Medicine Entering its second year as a distinct division, the Division of Population Health and Computational Medicine continues its work to harness data to improve outcomes for the diverse South Florida population. The Division’s work helps keep the MSOM on the cutting edge of new metrics for patient care, ensuring that we are on the forefront of developing tools that measure the quality of service rather than the quantities of patients seen. The mission of the Division is to study and apply methods that harness “big data” and make it translatable for health care. Faculty utilizes the University of Miami’s clinical data assets to develop improved care delivery models through the integration of medical informatics and clinical business process optimization, and then investigate the effects of these new care delivery models on patients, their families and health care providers.

MOBILIZING PHYSICIANS TO DISASTER RELIEF Division physicians Leonardo Tamariz, MD, and Ana Palacio, MD led a team of physicians to a devastated Ecuador in the wake of an earthquake that struck in April 2016. Drs. Tamariz and Palacio based their operations in Bahia de Caraquez and saw approximately 500 patients ranging from lack of medication to chikungunya and zika virus symptoms and chronic diseases such as diabetes and hypertension. They also took a survey of the health care offerings and needs in the area and helped direct donations from the UM community to Ecuador.

WORKING TO ERASE HEALTH DISPARITIES Associate Professor Erin Kobetz, PhD, MPH, also serves as the MSOM’s Senior Associate Dean for Health Disparities. In this role, she works to create a culture at UHealth where health equity is a priority achieved through research, clinical and educational endeavors. Dr. Kobetz is also the director of the Miami Clinical and Translational Science Award (CTSA) Community Engagement and Cultural Diversity Program. The UM CTSA program hub identified disproportionately high rates of suffering and death due to cervical cancer in Miami’s Little Haiti community, in part due to cultural and access barriers to early screening. The program trained community health workers to help change perceptions about screening, and also developed innovative tools to combat limited access to physicians and laboratory testing. UM investigators helped develop selfsampling diagnostics that women can perform outside the clinical setting to test for human papillomavirus (HPV), the leading primary cause of cervical cancer, and are developing an even faster paper-based test that could detect high-risk HPV in as little as 15 minutes.

David M. Seo, MD Division Chief Associate Professor Associate VP and Chief Information Officer Chief Medical Informatics Officer Chief Research Information Officer

DIVISION FACULTY LIST Professor of Medicine David M. Seo, MD Associate Professor of Medicine Erin Kobetz, PhD, MPH Associate Professors of Clinical Medicine Ana Palacio, MD, MPH Leonardo Tamariz, MD, MPH

Right: Dr. Erin Kobetz works with a diverse group of patients across the University of Miami and the Miami metropolitan area to address issues of health disparity – particularly when it comes to cancer. She is pictured here in Little Haiti, the largest Haitian settlement in the United States, where she has collaborated with community leaders for the past three years. Dr. Kobetz’s leadership will be instrumental as the Division collects data and integrates the application of social and cultural information into various clinical processes and systems.

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Division of Pulmonary, Allergy, Critical Care and Sleep Medicine The Division of Pulmonary, Allergy, Critical Care and Sleep Medicine’s faculty members are dedicated to a wide range of clinical services, as well as a robust portfolio of research investigations and to training fellows in programs in Pulmonary and Critical Care Medicine, Critical Care Medicine and Sleep Medicine. Matthias A. Salathe, MD Division Chief Professor of Medicine

While acute Zika infection is reportedly a short duration, self-limited illness, Center researchers will investigate whether there may be long-term effects on sleep and diurnal behavior. The Pittsburgh Sleep Quality Index, a standardized ten item sleep questionnaire, will be administered to Zika infected individuals on first confirming the diagnosis and sequentially in three month intervals for EMERGENT INTERVENTIONAL five years. The study aims to determine the PULMONOLOGY TECHNIQUES prevalence and type of sleep-related symptoms Under the leadership of new faculty member in the acute phase, the natural history of sleepDr. Sixto Alejandro Arias, the Division’s related symptomatology and to establish the interventional pulmonology service performs risk of long-term effects on sleep and alertness minimally invasive procedures that effectively following Zika infection. restore airway patency in patients with Although microcephaly is a well-recognized complex airway obstruction. Shortness condition resulting from Zika acquired during of breath commonly affects patients with the first two trimesters of pregnancy, other advanced cancers, and is occasionally secondary reports suggest the virus may also cause a to central airway obstruction. The Division’s interventionalists perform rigid bronchoscopy, a safe technique that allows complete control of the airway and the use different bronchoscopic techniques to ablate tumors, dilate stenosis and insert airway stents. Working collaboratively with colleagues from thoracic surgery, medical oncology and ear, nose and throat, the Division had multiple successful cases where this type of intervention facilitated weaning from mechanical ventilation, helped avoid tracheostomies, and most importantly improved quality of life for patients.

RESEARCHING LINK BETWEEN ZIKA AND SLEEP DISORDERS The UHealth Sleep Disorders Center plans to investigate the effect of Zika infection on sleep and diurnal behavior in adults and children. Following reports that patients infected with Zika show signs of extreme fatigue and the need for additional sleep, the Center plans to investigate the link between Zika and hypersomnia, which has been linked to other viral infections.

Above: Division fellows Rajan Garj and Stefanie Krick helped patient Adrian Alba and his family through his 22 days on ECMO. Left to Right: Dr. Garg, Mr. Alba, Dr. Krick

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DIVISION FACULTY LIST Professors of Medicine Horst J. Baier, MD, JD Marilyn K. Glassberg-Csete, MD Robert M. Jackson, MD Daniel H. Kett, MD Andrew A. Quartin, MD Matthias A. Salathe, MD Roland MH. Schein, MH, MD Adam Wanner, MD Associate Professors Michael A. Campos, MD Alejandro D. Chediak, MD Elio Donna, MD Shirin Shafazand, MD

Above: UHealth Sleep Center: Alejandro D. Chediak, M.D., Alexandre Abreu, M.D., Angelica Ortiz, M.D.

delayed form of microcephaly and behavioral and sleep disturbances in children, perhaps occurring when Zika infection occurs latter in the course of pregnancy. Sleep disturbances and delayed microcephaly are common in Angelman syndrome, a disorder caused by a mutation of UBE3A of chromosome 15. The Center plans to partner with colleagues in Brazil and in the United States to follow the course of children, seemingly healthy at birth, born to women with confirmed Zika infection during their pregnancies. The investigation aims to determine if there are long-term adverse developmental and/or sleep disorders in this population, to determine whether assessing for mutations of UBE3A is valuable if a clinical syndrome resembling Angelman syndrome occurs in a significant number of afflicted children.

DEDICATION TO CRITICALLY ILL PATIENTS In Critical Care Medicine, one case left a strong impression on both the patient’s family and the doctors who saved his life. When 34-year old patient Adrian Alba came to the University

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

of Miami emergency room, he was diagnosed with leptospirosis pulmonary hemorrhage and multi-organ dysfunction. Dr. David de la Zerda arranged for an immediate transfer to the Jackson Memorial Hospital Medical Intensive Care Unit (MICU) in time to start Mr. Alba on extracorporeal membrane oxygenation (ECMO) to provide both cardiac and respiratory support. Under Dr. Horst Baier as the MICU attending, then-fellows Drs. Rajan Garg and Stefanie Krick’s compassionate care helped the patient and his family through 22 days on ECMO, when at times it was unclear whether he would live. As a result of a remarkable multi-disciplinary, multi-institution effort, the patient survived. Writing of the experience, Mr. Alba’s mother said, “Dr. Garg and Dr. Krick were two angels sent to take care of my son.” MICU residents have presented the case as a quality improvement project presented to the American Thoracic Society, and the study will also be submitted to research journals. Mr. Alba continues under the care of the Division’s faculty to monitor his progress, and Dr. Krick went on to join the faculty of the Division as an Assistant Professor this year.

Assistant Professors Alexandre R. Abreu, MD Sixto A. Arias, MD Rafael Calderon-Candelario, MD David De La Zerda, MD Tanira D. Ferreira, MD Lauren M. Fine, MD Gregory E. Holt, MD, PhD Stefanie Krick, MD, PhD Mehdi Mirsaeidi, MD, MPH Andreas Schmid, MD Research Assistant Professor Eliana P. Mendes, MD Research Professor (Emeritus) Philip L. Whitney, PhD

Division of Rheumatology and Immunology

Eric L. Greidinger, MD Division Chief Associate Professor of Medicine

The Division of Rheumatology and Immunology provides care to patients in South Florida with the most complex and difficult to treat diagnoses and is also a top referral center for challenging cases from Latin America and the Caribbean. In addition to the main medical campus in Miami, the Division’s clinical practice has a presence in Deerfield Beach, Hialeah, Kendall and Plantation, and the faculty hold specialty clinics for patients with LUPUS, MIXED CONNECTIVE TISSUE DISEASE, MYOSITIS, RHEUMATOID ARTHRITIS, RHEUMATIC LUNG DISEASE, SJOGREN’S SYNDROME and VASCULITIS.

INTERNATIONAL LEADERSHIP AND COLLABORATION DIVISION FACULTY LIST Professor of Clinical Medicine Carlos J. Lozada, MD Associate Professors Dana P. Ascherman, MD Eric L. Greidinger, MD Elaine C. Tozman, MD Larry Young, MD Assistant Professors Maria F. Carpintero, MD Schartess Culpepper-Pace, MD Ozlem Pala, MD Christine Savage, MD

The Division is honored to announce that Carlos Lozada, Professor of Clinical Medicine, has been elected to the post of Secretary General of Pan-American League of Associations for Rheumatology (PANLAR). PANLAR is the leading organization in the Americas related to rheumatology, including national rheumatology societies, scientific societies, organizations for rheumatologyrelated health professionals, and rheumatic disease patient groups. This post enables Dr. Lozada to bring his focus and experience in rheumatology education to a hemispheric stage. He is helping establish curricula for rheumatology training throughout the Americas, as well as

consistent and rigorous certification standards for specialists to help bring more rheumatology expertise to places where it is needed. He is also supporting the efforts of PANLAR to provide more rheumatology training to primary care providers.

BREAKING DOWN BARRIERS FOR EFFICIENT PATIENT CARE The Division’s collaborative spirit has also led to improvements in patient care, especially in conditions which cross specialties, such as interstitial lung disease (ILD). Dr. Ascherman and pulmonologist Dr. Marilyn Glassberg have established one of the first combined pulmonary/rheumatology clinics for the treatment of ILD, allowing patients to see the full team of doctors in the same place at the same time. This innovative model helps patients start the best treatments for their conditions with the least delay, while providing improved opportunities to facilitate research projects and monitor ongoing therapy both for efficacy and side effects. The Division hopes to apply the success of the combined rheumatology-pulmonary clinics to other rheumatic diseases, and provide a model for how to plan, organize, and implement patient-centered multidisciplinary clinics that could be applicable to many other types of conditions.

Left: Dr. Carlos Lozada, Professor of Clinical Medicine, Fellowship Director, and Secretary General of Pan-American League of Associations for Rheumatology (PANLAR) examines a patient.

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Department Publications CARDIOVASCULAR Alfonso CE, Cohen MG. Diagnostic and guide catheter selection and manipulation for radial approach. Interventional Cardiology Clinics 2015;4:145159. Badheka AO, Patel NJ, Grover P, Singh V, Patel N, Arora S, Chothani A, Mehta K, Deshmukh A, Savani GT, Patel A, Panaich SS, Shah N, Rathod A, Brown M, Mohamad T, Makkar RR, Schreiber T, Grines CL, Rihal CS, Cohen MG. Response to letter regarding article “Impact of annual operator and institutional volume on percutaneous coronary intervention outcomes: A 5-year United States experience (2005–2009)”. Circulation 2015/08/03 2015;132:e36-e37. Brown WV, Mackey RH, Orringer CE, Pearson TA. JCL roundtable: Gender differences in reduction of CVD in response to lipid-lowering drugs. J Clin Lipidol Sep-Oct 2015;9:624-633. Cao Y, Balkan W, Hare JM. S-nitrosylation and msc-mediated body composition. Oncotarget Oct 6 2015;6:28517-28518.PMC4745665. Chothani A, Shah N, Patel NJ, Deshmukh A, Singh V, Patel N, Panaich SS, Arora S, Patel A, Savani C, Thakkar B, Bhatt P, Cohen MG, Grines C, Forrest JK, Badheka AO. Vaccination serology status and cardiovascular mortality: Insight from NHANES III and continuous NHANES. Postgrad Med 2015/07/15 2015;127:561564. Chung HS, Murray CI, Venkatraman V, Crowgey EL, Rainer PP, Cole RN, Bomgarden RD, Rogers JC, Balkan W, Hare JM, Kass DA, Van Eyk JE. Dual labeling biotin switch assay to reduce bias derived from different cysteine subpopulations: A method to maximize S-nitrosylation detection. Circ Res Oct 23 2015;117:846-857. Cohen MG, Matthews R, Maini B, Dixon S, Vetrovec G, Wohns D, Palacios I, Popma J, Ohman EM, Schreiber T, O’Neill WW. Percutaneous left ventricular assist device for high-risk percutaneous coronary interventions: Real-world versus clinical trial experience. Am Heart J Nov 2015;170:872-879. Damluji AA, Al-Damluji MS, Marzouka GR, Coffey JO, Viles-Gonzalez JF, Cohen MG, Moscucci M, Myerburg RJ, Mitrani RD. New-onset versus prior history of atrial fibrillation: Outcomes from the AFFIRM trial. Am Heart J Jul 2015;170:156-163, 163.e151. Damluji AA, Otalvaro L, Cohen MG. Anticoagulation for percutaneous coronary intervention: A contemporary review. Curr Opin Cardiol Jul 2015;30:311-318. Deshmukh A, Patel N, Noseworthy PA, Patel AA, Patel N, Arora S, Kapa S, Noheria A, Mulpuru S, Badheka A, Fischer A, Coffey JO, Cha YM, Friedman P, Asirvatham S, Viles-Gonzalez JF. Trends in use and adverse outcomes associated with transvenous lead removal in the United States. Circulation Dec 22 2015;132:2363-2371. Deyell MW, Krahn AD, Goldberger JJ. Sudden cardiac death risk stratification. Circ Res Jun 5 2015;116:1907-1918.PMC4466101. Estes NA, 3rd, Kovacs RJ, Baggish AL, Myerburg RJ. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task force 11: Drugs and performance-enhancing substances: A scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol Dec 1 2015;66:2429-2433.

Goldberger JJ, Hendel RC. Decision making for implantable cardioverter defibrillator implantation: Is there a role for neurohumoral imaging? Circ Cardiovasc Imaging Dec 2015;8. Gordon D, Goldberger JJ, Arora R, Aistrup GL, Ng J. Searching for “order” in atrial fibrillation using electrogram morphology recurrence plots. Comput Biol Med Oct 1 2015;65:220-228. Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, Li J, Shehadeh LA, Hare JM, David V, Martin A, Fornoni A, Di Marco GS, Kentrup D, Reuter S, Mayer AB, Pavenstadt H, Stypmann J, Kuhn C, Hille S, Frey N, Leifheit-Nestler M, Richter B, Haffner D, Abraham R, Bange J, Sperl B, Ullrich A, Brand M, Wolf M, Faul C. Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy. Cell Metab Dec 1 2015;22:1020-1032.PMC4670583. Hare JM, Sanina C. Bone marrow mononuclear cell therapy and granulocyte colony-stimulating factor for acute myocardial infarction: Is it time to reconsider? J Am Coll Cardiol Jun 9 2015;65:2383-2387. Hatzistergos KE, Hare JM. Cell therapy: Targeting endogenous repair versus remuscularization. Circ Res Sep 25 2015;117:659-661.PMC4705032. Hatzistergos KE, Paulino EC, Dulce RA, Takeuchi LM, Bellio MA, Kulandavelu S, Cao Y, Balkan W, Kanashiro-Takeuchi RM, Hare JM. S-nitrosoglutathione reductase deficiency enhances the proliferative expansion of adult heart progenitors and myocytes post myocardial infarction. J Am Heart Assoc Jul 2015;4.PMC4608081. Hatzistergos KE, Takeuchi LM, Saur D, Seidler B, Dymecki SM, Mai JJ, White IA, Balkan W, Kanashiro-Takeuchi RM, Schally AV, Hare JM. C-kit+ cardiac progenitors of neural crest origin. Proc Natl Acad Sci USA Oct 20 2015;112:13051-13056.PMC4620867. Healy C, Viles-Gonzalez JF, Sacher F, Coffey JO, d’Avila A. Management of ventricular arrhythmias in patients with mechanical ventricular support devices. Curr Cardiol Rep Aug 2015;17:59. Healy C, Viles-Gonzalez JF, Saenz LC, Soto M, Ramirez JD, d’Avila A. Arrhythmias in Chagasic cardiomyopathy. Card Electrophysiol Clin Jun 2015;7:251-268. Husby MP, Soliman EZ, Goldberger JJ, Liu K, Lloyd-Jones D, Durazo-Arvizu R, Kramer H. The association between the PR interval and left ventricular measurements in the multiethnic study of atherosclerosis. Cardiol Res Pract 2015;2015:193698.PMC4629021. Jacobson TA, Maki KC, Orringer CE, Jones PH, Kris-Etherton P, Sikand G, La Forge R, Daniels SR, Wilson DP, Morris PB, Wild RA, Grundy SM, Daviglus M, Ferdinand KC, Vijayaraghavan K, Deedwania PC, Aberg JA, Liao KP, McKenney JM, Ross JL, Braun LT, Ito MK, Bays HE, Brown WV, Underberg JA. National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 2. J Clin Lipidol Nov-Dec 2015;9:S1-122.e121. Kaiser K, Cheng WY, Jensen S, Clayman ML, Thappa A, Schwiep F, Chawla A, Goldberger JJ, Col N, Schein J. Development of a shared decision-making tool to assist patients and clinicians with decisions on oral anticoagulant treatment for atrial fibrillation. Curr Med Res Opin Dec 2015;31:2261-2272. Karantalis V, Hare JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res 2015;116:1413-1430.

Figueiredo-Freitas C, Dulce RA, Foster MW, Liang J, Yamashita AM, Lima-Rosa FL, Thompson JW, Moseley MA, Hare JM, Nogueira L, Sorenson MM, Pinto JR. S-nitrosylation of sarcomeric proteins depresses myofilament Ca2+)sensitivity in intact cardiomyocytes. Antioxid Redox Signal Nov 1 2015;23:1017-1034. PMC4649751.

Karantalis V, Suncion-Loescher VY, Bagno L, Golpanian S, Wolf A, Sanina C, Premer C, Kanelidis AJ, McCall F, Wang B, Balkan W, Rodriguez J, Rosado M, Morales A, Hatzistergos K, Natsumeda M, Margitich I, Schulman IH, Gomes SA, Mushtaq M, DiFede DL, Fishman JE, Pattany P, Zambrano JP, Heldman AW, Hare JM. Synergistic effects of combined cell therapy for chronic ischemic cardiomyopathy. J Am Coll Cardiol Nov 3 2015;66:1990-1999.PMC4628729.

Ghatak A, Singh V, Shantha GP, Badheka A, Patel N, Alfonso CE, Biswas M, Pancholy SB, Grines C, O’Neill WW, de Marchena E, Cohen MG. Aspiration thrombectomy in patients undergoing primary angioplasty for ST-elevation myocardial infarction: An updated meta-analysis. J Interv Cardiol Dec 2015;28:503-513.

Kim MH, Zhang Y, Sakaguchi S, Goldberger JJ. Time course of appropriate implantable cardioverter-defibrillator therapy and implications for guidelinebased driving restrictions. Heart Rhythm Aug 2015;12:1728-1736.

Goldberger JJ, Arora R, Green D, Greenland P, Lee DC, Lloyd-Jones DM, Markl M, Ng J, Shah SJ. Evaluating the atrial myopathy underlying atrial fibrillation: Identifying the arrhythmogenic and thrombogenic substrate. Circulation Jul 28 2015;132:278-291.PMC4520257. Goldberger JJ, Bonow RO, Cuffe M, Liu L, Rosenberg Y, Shah PK, Smith SC, Jr., Subacius H, OBTAIN Investigators. Effect of beta-blocker dose on survival after acute myocardial infarction. J Am Coll Cardiol Sep 29 2015;66:1431-1441. PMC4583654.

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Kolder IC, Tanck MW, Postema PG, Barc J, Sinner MF, Zumhagen S, Husemann A, Stallmeyer B, Koopmann TT, Hofman N, Pfeufer A, Lichtner P, Meitinger T, Beckmann BM, Myerburg RJ, Bishopric NH, Roden DM, Kaab S, Wilde AA, Schott JJ, Schulze-Bahr E, Bezzina CR. Analysis for genetic modifiers of disease severity in patients with long-QT syndrome type 2. Circ Cardiovasc Genet Jun 2015;8:447-456.PMC4770255. Lardizabal JA, Macon CJ, O’Neill BP, Desai H, Singh V, Martinez CA, Alfonso CE, Cohen MG, Heldman AW, O’Neill WW, Williams DB. Long-term outcomes associated with the transaortic approach to transcatheter aortic valve replacement. Catheter Cardiovasc Interv Jun 2015;85:1226-1230.

Department Publications Lee DC, Markl M, Ng J, Carr M, Benefield B, Carr JC, Goldberger JJ. Threedimensional left atrial blood flow characteristics in patients with atrial fibrillation assessed by 4D flow CMR. Eur Heart J Cardiovasc Imaging Nov 20 2015.

Wolinsky D, Hendel R, Cerqueira M, Gold M, Narula J, Singh J, Shaw L, Thomas G, Wazni O, Farnum C. The role of I-123 metaiodobenzylguanidine imaging in management of patients with heart failure. Am J Cardiol Oct 15 2015;116 Suppl 1:S1-9.

Link MS, Myerburg RJ, Estes NA, 3rd. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task force 12: Emergency action plans, resuscitation, cardiopulmonary resuscitation, and automated external defibrillators: A scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol Dec 1 2015;66:2434-2438.

Wu GM, Damluji A, Alansari YE, Kabach M, Murman M, Novoa IC, Healy C, Carillo R, Williams D, de Marchena E, Martinez CA, Alfonso C, Moscucci M, Heldman AW, Cohen MG, Mitrani R, Leroux L. TCT-658 left bundle branch block and need for permanent pacemaker post TAVR. J Am Coll Cardiol 2015;66.

Markl M, Fluckiger J, Lee DC, Ng J, Goldberger JJ. Velocity quantification by electrocardiography-gated phase contrast magnetic resonance imaging in patients with cardiac arrhythmia: A simulation study based on real time transesophageal echocardiography data in atrial fibrillation. J Comput Assist Tomogr May-Jun 2015;39:422-427.PMC4435847. McNamara DA, Goldberger JJ, Berendsen MA, Huffman MD. Implantable defibrillators versus medical therapy for cardiac channelopathies. Cochrane Database Syst Rev 2015Cd011168.

Zipes DP, Link MS, Ackerman MJ, Kovacs RJ, Myerburg RJ, Estes NA, 3rd. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task force 9: Arrhythmias and conduction defects: A scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol Dec 1 2015;66:2412-2423.

Orringer CE, Bays HE, Brown WV. Clinical lipidology: A subspecialty whose time has come. J Clin Lipidol Sep-Oct 2015;9:634-639.

CLINICAL PHARMACOLOGY

Patel NJ, Patel A, Agnihotri K, Pau D, Patel S, Thakkar B, Nalluri N, Asti D, Kanotra R, Kadavath S, Arora S, Patel N, Patel A, Sheikh A, Patel N, Badheka AO, Deshmukh A, Paydak H, Viles-Gonzalez J. Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes, heart failure and chronic kidney disease. World J Cardiol Jul 26 2015;7:397-403.PMC4513491. Patel NJ, Singh V, Patel SV, Savani C, Patel N, Panaich S, Arora S, Cohen MG, Grines C, Badheka AO. Percutaneous coronary interventions and hemodynamic support in the USA: A 5 year experience. J Interv Cardiol Dec 2015;28:563-573. Sacher F, Reichlin T, Zado ES, Field ME, Viles-Gonzalez JF, Peichl P, Ellenbogen KA, Maury P, Dukkipati SR, Picard F, Kautzner J, Barandon L, Koneru JN, Ritter P, Mahida S, Calderon J, Derval N, Denis A, Cochet H, Shepard RK, Corre J, Coffey JO, Garcia F, Hocini M, Tedrow U, Haissaguerre M, dâ&#x20AC;&#x2122;Avila A, Stevenson WG, Marchlinski FE, Jais P. Characteristics of ventricular tachycardia ablation in patients with continuous flow left ventricular assist devices. Circ Arrhythm Electrophysiol Jun 2015;8:592-597. Sanina C, Hare JM. Mesenchymal stem cells as a biological drug for heart disease: Where are we with cardiac cell-based therapy? Circ Res Jul 17 2015;117:229-233.PMC4571454. Sheikh A, Patel NJ, Nalluri N, Agnihotri K, Spagnola J, Patel A, Asti D, Kanotra R, Khan H, Savani C, Arora S, Patel N, Thakkar B, Patel N, Pau D, Badheka AO, Deshmukh A, Kowalski M, Viles-Gonzalez J, Paydak H. Trends in hospitalization for atrial fibrillation: Epidemiology, cost, and implications for the future. Prog Cardiovasc Dis Sep-Oct 2015;58:105-116. Thompson PD, Myerburg RJ, Levine BD, Udelson JE, Kovacs RJ. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task force 8: Coronary artery disease: A scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol Dec 1 2015;66:2406-2411.

Preston RA, Afshartous D, Rodco R, Alonso AB, Garg D. Evidence for a gastrointestinal-renal kaliuretic signaling axis in humans. Kidney International 2015; 88:1383-1391. Preston RA, Marbury TC, Wajima T, Graham S. The effect of renal and hepatic impairment on the pharmacokinetics of ospemifene, a tissue-selective estrogen agonist/antagonist. American Journal of Therapeutics. 2015; 22:171-81. Materson BJ, Garcia-Estrada M, Preston RA. Hypertension in the frail elderly. J Am Soc Hypertens 2016; 10:536-541. Materson BJ. Allopurinol: Can it undo the harm done by high dietary fructose? J Am Soc Hypertens 2016; 10:474-475.

ENDOCRINOLOGY, DIABETES AND METABOLISM Mather KJ, Kim C, Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F, Kahn SE, Goldberg RB, Barrett-Connor E; Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program. Diabetes Prevention Program. J Clin Endocrinol Metab. 2015 Oct;100(10):3778-86. Diabetes Prevention Program Research Group (Goldberg RB Author). Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015 Nov;3(11):866-75. PMID: 26377054 Local and Systemic effects of the multifaceted Epicardial Adipose Tissue Depot. Iacobellis G. Nature Reviews Endocrinology 2015;11:363-371

Tompkins B, Balkan W, Hare JM. Perspectives on the evolution of stem cell therapy for heart failure. EBioMedicine Dec 2015;2:1838-1839.PMC4703738.

Hayward RA, Reaven PD, Wiitala WL, Bahn GD, Reda DJ, Ge L, McCarren M, Duckworth WC, Emanuele NV; VADT Investigators (Goldberg RB Author). Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015 Jun 4;372(23):2197-206. doi: 10.1056/NEJMoa1414266.

Van Hare GF, Ackerman MJ, Evangelista JA, Kovacs RJ, Myerburg RJ, Shafer KM, Warnes CA, Washington RL. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task force 4: Congenital heart disease: A scientific statement from the a American Heart Association and American College of Cardiology. J Am Coll Cardiol Dec 1 2015;66:2372-2384.

Pugliese A, Boulware D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molina C, Harrison LC, Schatz D, Palmer JP, Greenbaum C, Eisenbarth GS, Sosenko JM, the Type 1 Diabetes TrialNet Study Group. The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects AutoantibodyPositive Relatives from Type 1 Diabetes Throughout the Stages of Disease Progression. Diabetes. 2016;65(4):1109-19.

Washam JB, Herzog CA, Beitelshees AL, Cohen MG, Henry TD, Kapur NK, Mega JL, Menon V, Page RL, Newby LK. Pharmacotherapy in chronic kidney disease patients presenting with acute coronary syndrome a scientific statement from the American Heart Association. Circulation 2015;131:1123-1149.

Klein D, Alvarez-Cubela S, Lanzoni G, Vargas N, Prabakar K, Boulina M, Ricordi C, Inverardi L, Pastori RL, Dominguez-Bendala J. BMP-7 induces adult human pancreatic exocrine-to-endocrine conversion. Diabetes. 64(12):4123-4134, 2015. IF: 8.47

White IA, Gordon J, Balkan W, Hare JM. Sympathetic reinnervation is required for mammalian cardiac regeneration. Circ Res Dec 4 2015;117:990-994. PMC4705031.

F. Vendrame, Y-Y. Hopfner, S. Diamantopoulos, S.K. Virdi, G. Allende, I.V. Snowhite, H.K. Reijonen, L. Chen, P. Ruiz, G. Ciancio, J.C. Hutton, S. Messinger, D.W. Burke III and A. Pugliese. Risk Factor for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants. Am J Transplant. 2016;16(1):235-45.

Winchester DE, Moseley RE, Hendel R. The business of accreditation. J Nucl Cardiol Jun 2015;22:504-506.

Yuan CC, Muthu P, Kazmierczak K, Liang J, Huang W, Irving TC, KanashiroTakeuchi RM, Hare JM, Szczesna-Cordary D. Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice. Proc Natl Acad Sci U S A Jul 28 2015;112:E4138-4146. PMC4522794.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Alberto Pugliese, David Boulware, Liping Yu, Sunanda Babu, Andrea K. Steck, Dorothy Becker, Henry Rodriguez, Linda DiMeglio, Carmella Evans-Molina, Leonard C. Harrison, Desmond Schatz, Jerry P. Palmer, Carla Greenbaum, George S. Eisenbarth, Jay M. Sosenko and the Type 1 Diabetes TrialNet Study Group. The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression. Diabetes. 2016;65(4):1109-19.

Parikh, J, Kerman, DH, Garcia-Buitrago,M. Adalimumab-Induced Apoptotic Enteropathy, Colorectal Dis. 2016 Jan 22.

Aixin Yu, Isaac Snowhite, Francesco Vendrame, Michelle Rosenzwajg, David Klatzmann, Alberto Pugliese, and Thomas R. Malek. Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes. Diabetes. 2015 Jun;64(6):2172-83

Martin P, Lau DT, Nguyen MH, Janssen HL, Dieterich DT, Peters MG, Jacobson IM. A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2015 Update. Clin Gastroenterol Hepatol. 2015 Nov; 13(12):2071-87.

Mechanisms in Support of Low-Dose IL-2 Therapy in Type 1 Diabetes Yu et al. Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 2015;64:2172–2183 Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW 3rd, Pugliese A. Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants. Am J Transplant. 2016 Jan;16(1):235-45. Alejandro EU, Bozadjieva N, Kumusoglu D, Abdulhamid S, Levine H, Haataja L, Vadrevu S, Satin LS, Arvan P, Bernal-Mizrachi E. Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure. Cell Rep. 2015 Dec 22;13(11):2527-38. Abdulreda MH, Rodriguez-Diaz R, Caicedo A, Berggren PO. Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model. Cell Metab. 2016 Mar 8;23(3):541-6. Blandino-Rosano, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N and Bernal-Mizrachi E.. 4E-BP2/SH2B1/ IRS2 are part of a novel feedback loop that controls β-cell mass. Diabetes. 2016 May 23. pii: db151443. [Epub ahead of print]

GASTROENTEROLOGY Dheer R, Santaolalla R, Davies JM, Lang JK, Phillips MC, Pastorini C, VazquezPertejo M and Abreu MT. Intestinal epithelial TLR4 signaling affects epithelial function, colonic microbiota and promotes risk for transmissible colitis. Infect Immun. 2016 Jan 11. pii: IAI.01374-15. [Epub ahead of print] Dheer R, Davies JM, Abreu MT. Inflammation and Colorectal Cancer. In Intestinal Tumorigenesis 2015 (pp. 211-256). Springer International Publishing Sussman DA, Berera S, Koru-Sengul T, Miao F, Carrasquillo O, Nadji M, Zhang Y, Hosein PJ, McCauley JL, Abreu MT. Colorectal Tumors from Different Racial and Ethnic Minorities Have Similar Rates of Mismatch Repair Deficiency.Clin Gastroenterol Hepatol. 2016 Apr 1. pii: S1542-3565(16)30012-X. doi: 10.1016/j. cgh.2016.03.037. [Epub ahead of print] Davies JM, Santaolalla R, von Furstenberg RJ, Henning SJ, Abreu MT. The Viral Mimetic Polyinosinic : Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures. PLoS One. 2015 Sep 28;10(9):e0138531. Yarur AJ1, Jain A, Hauenstein SI, Quintero MA, Barkin JS, Deshpande AR, Sussman DA, Singh S, Abreu MT. Higher Adalimumab Levels Are Associated with Histologic and Endoscopic Remission in Patients with Crohn’s Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2016 Feb;22(2):409-15. doi: 10.1097/ MIB.0000000000000689. Sussman DA, Barkin JA, Martin AM, Varma T, Clarke J, Quintero MA, Barkin HB, Deshpande AR, Barkin JS, Abreu MT. Development of Advanced Imaging Criteria for the Endoscopic Identification of Inflammatory Polyps. Clin Transl Gastroenterol. 2015 Nov 19;6:e128. doi: 10.1038/ctg.2015.51. Diaz L, Hernandez RE, Deshpande AR, Moshiree B. Upper gastrointestinal involvement in Crohn Disease (CD): a systematic review of histopathologic and endoscopic findings. South Med J 2015;108(11):695-70. Damas OM, Deshpande AR, Avalos DJ, Abreu MT. Treating inflammatory bowel disease in pregnancy: the issues we face today. J Crohns Colitis 2015;9(10):928-36.

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Kerman, DH, “Endoscopic Delivery of Fecal Biotherapy” in Gastroenterology Clinics of North America.

HEPATOLOGY

Fabrizi F, Verdesca S, Messa P, Martin P. Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and MetaAnalysis. Dig Dis Sci. 2015 Dec; 60(12):3801-13. Hirschfield GM, Gershwin ME, Strauss R, Mayo MJ, Levy C, Zou B, Johanns J, Nnane IP, Dasgupta B, Li K, Selmi C, Marschall HU, Jones D, Lindor K, PURIFI Study Group. Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to Ursodeoxycholic Acid: a proof-of-concept study. Hepatology. 2015 Nov; 24. doi: 10.1002/hep.28359 [Epub ahead of print]. Poordad F, Schiff ER, Vierling JM, Landis C, Fontana RJ, Yang R, McPhee F, Hughes EA, Noviello S, Swenson ES. Daclatasvir With Sofosbuvir and Ribavirin for HCV Infection With Advanced Cirrhosis or Post-Liver Transplant Recurrence. Hepatology. 2016 Jan; 11. doi: 10.1002/hep.28446. [Epub ahead of print]. Calmet FH, Yarur AJ, Pukazhendhi G, Ahmad J, Bhamidimarri KR. Endoscopic and histological features of mycophenolate mofetil colitis in patients after solid organ transplantation. Ann Gastroenterol. 2015 Jul-Sept; 28(3):366-373. AASLD/IDSA HCV Guidance Panel (P Martin Panel Member). Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Hepatology. 2015 Sept; 62(3):932-954.

GENERAL INTERNAL MEDICINE Sclair SN, Carrasquillo O, Czul F, Trivella JP, Li H, Jeffers L, Martin P. Quality of Care Provided by Hepatologists to Patients with Cirrhosis at Three Parallel Health Systems. Dig Dis Sci. 2016 Jun 11. PMID: 27289585 Kenya S, Okoro IS, Wallace K, Ricciardi M, Carrasquillo O, Prado G. Can HomeBased HIV Rapid Testing Reduce HIV Disparities Among African Americans in Miami? Health Promot Pract. 2016 Apr 18. PMID: 27091604 Ilangovan K, Kobetz E, Koru-Sengul T, Marcus EN, Rodriguez B, Alonzo Y, Carrasquillo O. Acceptability and Feasibility of Human Papilloma Virus SelfSampling for Cervical Cancer Screening. J Womens Health (Larchmt). 2016 Feb 18. [Epub ahead of print] PMID: 26890012 Fiore RN, Goodman KW. Precision medicine ethics: selected issues and developments in next-generation sequencing, clinical oncology and ethics. Curr Opin Oncol. 2016 Jan;28(1):83-7. doi: 10.1097/CCO.0000000000000247. PMID: 26569425

GERIATRICS AND PALLIATIVE CARE Munshi MN, Florez H, Huang ES, et al Management of Diabetes in Long-term Care and Skilled Nursing Facilities: A Position Statement of the American Diabetes Association. Diabetes Care. 2016 Feb;39(2):308-18. doi: 10.2337/ dc15-2512.

HEMATOLOGY Perna F, Vu LP, Themeli M, Kriks S, Hoya-Arias R, Khanin R, Hricik T, MansillaSoto J, Papapetrou EP, Levin RL, Studer L, Sadelain M, Nimer SD. The Polycomb Group Protein L3MBTL1 Represses a SMAD5-Mediated Hematopoietic Transcriptional Program in Human Pluripotent Stem Cells. Stem Cell Reports 4:658-669, 2015 [JIF 5.365 (2014)]. Wang L, Man N, Sun XJ, Tan Y, Cao MG, Liu F, Hatlen M, Xu H, Huang G, Mattlin M, Mehta A, Rampersaud E, Benezra R, Nimer SD. Regulation of AKT signaling by Id1 controls t (8;21) leukemia initiation and progression. Blood 126:640650, 2015 (JIF 10.452 (2014)].

Department Publications Liu F, Chen G, Hamard PJ, Greenblatt S, Wang L, Man N, Perna F, Xu H, Tadi M, Luciani L, Nimer SD, Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest 125:3532-3544, 2015 (JIF 13.215 (2014)]. Wang L, Hamard PJ, Nimer SD, PARP inhibitors: a treatment option for AML? Nat Med 21:1393-4, 2015 [JIF 27.363 (2014)]. Zhang Y, Gallastegui N, Rosenblatt JD. Regulatory B cells in anti-tumor immunity. Int Immunol 27:521-30, 2015 (JIF 2,536 (2014)]. Swords RT, Erba HP, DeAngelo DJ, Bixby DL, Altman JK, Maris M, Hua Z, Blakemore SJ, Faessel H, Sedarati F, Dezube BJ, Giles FJ, Medeiros BC. Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study. Br J Haematol 169:534-43, 2015 (JIF 4.711 (2014)]. Komanduri KV, Levin RL. Diagnosis and Therapy of Acute Myeloid Leukemia in the Era of Molecular Risk Stratification. Annu Rev Med 67:59-72, 2016. [JIF unavailable]. Kozlosky GA, Jiang X, Bhatt S, Ruiz J, Vega F, Shaknovich R, Melnick A, Lossos IS. MiR-181a negatively regulates NF-?B signaling and affects activated B-cell like diffuse large B-cell lymphoma pathogenesis. Blood; 2016 [JIF unavailable]. Hatlen MA, Arora K, Vacic V, Grabowska EA, Liao W, Riley-Gillis B, Oschwald DM, Wang L, Joergens JE, Shih AH, Rapaport F, Gu S, Voza F, Asai T, Neel BG, Kharas MG, Gonen M, Levin RL, Nimer SD. Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles. J Exp Med 213:25-34, 2016. [JIF unavailable].

INFECTIOUS DISEASE Alcaide M, Feaster D, Duan R, Cohen S, Diaz C, Castro J, Golden M, Henn S, Colfax G, Metsch L. The incidence of Trichomonas vaginalis infection in women attending nine sexually transmitted disease clinics in the USA. Sex Transm Infect 2016 Feb;92(1):58-62. doi:10.1136/sextrans-2015-05210. PMID: 26071390. Strbo N, Alcaide ML, Romero L, Bolivar H, Jones D, Podack ER, Fischl MA. Loss of Intra-Epithelial Endocervical Gamma Delta (GD) 1 T Cells in HIV-Infected Women. Am J Reprod Immunol. 2016 Feb;75(2):134-45. doi: 10.1111/aji.12458. [Epub ahead of print] PMID:26666220 Alcaide ML, Chisembele M, Malupande E, Arheart K, Fischl M, Jones DL. A cross-sectional study of bacterial vaginosis, intravaginal practices and HIV genital shedding; implications for HIV transmission and women’s health. BMJ Open. 2015 Nov 9;5(11):e009036. doi: 10.1136/bmjopen-2015-009036. PMID: 26553833 Alcaide ML, Cook R, Chisembele M, Malupande E, Jones DL. Determinants of intravaginal practices among HIV-infected women in Zambia using conjoint analysis. Int J STD AIDS. 2015 May 8. pii: 0956462415585447. PMID: 25957322 Castro JG, Alcaide ML. High Rates of STIs in HIV-Infected Patients Attending an STI Clinic. South Med J. 2016 Jan;109(1):1-4. doi: 10.14423/ SMJ.0000000000000389. PMID: 26741862 Coll AS, Potter JE, Chakhtoura N, Alcaide ML, Cook R, Jones DL. Providers’ perspectives on preconception counseling and safer conception for HIV-infected women. AIDS Care. 2015 Nov 18:1-6. [Epub ahead of print] PMID: 26577664

Asai T, Hatlen MA, Lossos C, Ndiaye-Lobry D, Deblasio A, Murata K, Fleisher M, Cortizas EM, Verdun RE, Petrini J, Nimer SD. Generation of a novel, multistage, progressive, and transplantable mode of plasma cell neoplasms. Sci Rep 6:22760, 2016 (JIF unavailable].

DʼSouza G, Burk RD, Palefsky JM, Massad LS, Strickler HD; WIHS HPV Working Group. Cervical human papillomavirus testing to triage borderline abnormal pap tests in HIV-coinfected women. AIDS. 2014 Jul 17;28(11):1696-8. doi: 10.1097/QAD.0000000000000285. No abstract available. PMID: 25232904

Matthews JM, Bhatt S, Patricelli MP, Nomanbhoy TK, Jian X, Natkunam Y, Gentles AJ, Martinez E, Zhu D, Chapman JR, Cortizas E, Shyam R, Chinichian S, Advni R, Tan L, Zhang J,

Understanding HIV Care Provider Attitudes Regarding Intentions to Prescribe PrEP. Castel AD, Feaster DJ, Tang W, Willis S, Jordan H, Kolber M, Rodriguez AE et al. Journal of acquired immune deficiency syndromes (1999). 2015; 70(5):520-8. NIHMSID: NIHMS710820 PubMed [journal]PMID: 26247895 PMCID: PMC4644475

Choi HG, Tibshirani R, Buhriage SJ, Gratzinger D, Verdun R, Gray NS, Lossos IS. Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma. Blood: 2016 [JIF unavailable].

MEDICAL ONCOLOGY Ao Z, Shah SH, Machlin LM, Parajuli R, Miller PC, Rawal S, Williams AJ, Cote RJ, Lippman ME, Datar RH, El-Ashry D. Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer. Cancer Res 75:4681-7,2015 [JIF 9.329 (2014)]. Li L, Paz AC, Wilky BA, Johnson B, Galoian K, Rosenberg A, Hu G, Tinoco G, Bodamer O, Trent JC. Treatment with a Small Molecular Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hdroxyglutarate in Human Chondrosarcoma Cells. PLoS One 10:e0133813.2015 [JIF 3.234 (2014)]. Picon-Ruiz M, Pan C, Drews-Elger K, Jang K, Besser AH, Zhao D, Morata-Tarifa C, Kim M, Ince TA, Azzam DJ, Wander SA, Wang B, Ergonul B, Datar RH, Cote RJ, Howard GA, El-Ashry D, Torné-Poyatos P, Marchal JA, Slingerland JM. Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression. Cancer Res 76:491-504, 2016 [JIF unavailable].

HOSPITAL MEDICINE Brodelon, J., Abbas, U., Shabbir, A., Ross, A.: Rewriting History: Fever of Unknown Origin. American Journal of Medicine, Vol 128 No. 9, September 2015 Dutta S, Cohn SL, Pfeifer KJ, Slawski BA, Smetana GW, Jaffer AK. Update in perioperative medicine. J Hosp Med 11(3):231-6, 2016 Cohn SL. The cardiac consult for patients undergoing non-cardiac surgery. Heart 2016 (accepted for publication). Cohn SL, Geise G. Periaoperative Cardiovascular Risk Assessment and Modification. Hosp Med Clinics (in press 2016). Imm M. “Pimping as a Practice in Medical Education” JAMA. 2016 May 24-31; 315(20):2235-6

The Contribution of Missed Clinic Visits to Disparities in HIV Viral Load Outcomes. Zinski A, Westfall AO, Gardner LI, Giordano TP, Wilson TE, Rodriguez AE et al. American journal of public health. 2015; 105(10):2068-75. PubMed [journal]PMID: 26270301 Impact of a Multifaceted Intervention on Promoting Adherence to Screening Colonoscopy Among Persons in HIV Primary Care: A Pilot Study. Ferron P, Asfour SS, Metsch LR, Antoni MH, Rodriguez AE, et al. Clinical and translational science. 2015; 8(4):290-7. NIHMSID: NIHMS680444 PubMed [journal]PMID: 25996255 PMCID: PMC4553070 Time above 1500 copies: a viral load measure for assessing transmission risk of HIV-positive patients in care.Marks G, Gardner LI, Rose CE, Zinski A, Moore RD, , Rodriguez AE et al. AIDS (London, England). 2015; 29(8):947-54.PubMed [journal]PMID: 25768835 Susanna Naggie , Curtis Cooper Michael Saag , Kimberly Workowski , Peter Ruane , William J. Towner , Kristen Marks , Anne Luetkemeyer , Rachel P. Baden , Paul E. Sax, Edward Gane, Jorge Santana-Bagur, Luisa M. Stamm, Jenny C. Yang, Polina German, Liyun Ni, Phillip S. Pang, John G. McHutchison, Catherine A. M. Stedman, Javier O. Morales-Ramirez, Norbert Bräu, Dushyantha Jayaweera. Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1. N Engl J Med. 2015 Aug 20;373(8):705-13. Preexposure Prophylaxis for HIV Infection Integrated With Municipal- and Community-Based Sexual Health Services. Liu AY, Cohen SE, Vittinghoff E, Anderson PL, Doblecki-Lewis S, Bacon O, Chege W, Postle BS, Matheson T, Amico KR, Liegler T, Rawlings MK, Trainor N, Blue RW, Estrada Y, Coleman ME, Cardenas G, Feaster DJ, Grant R, Philip SS, Elion R, Buchbinder S, Kolber MA. JAMA Intern Med. 2016 Jan 1;176(1):75-84. doi: 10.1001/ jamainternmed.2015.4683. PMID: 26571482 Understanding HIV Care Provider Attitudes Regarding Intentions to Prescribe PrEP. Castel AD, Feaster DJ, Tang W, Willis S, Jordan H, Villamizar K, Kharfen M, Kolber MA, Rodriguez A, Metsch LR. J Acquir Immune Defic Syndr. 2015 Dec 15;70(5):520-8.

Lenchus JD. Transitions in the prophylaxis, treatment and care of patients with venous thromboembolism. Adv Ther. January 2016;33(1):29-45.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

NEPHROLOGY AND HYPERTENSION Roth D, Nelson DR, Bruchfeld A, Liapakis A, Silva M, Monsour H Jr, Martin P, Pol S, Londoño MC, Hassanein T, Zamor PJ, Zuckerman E, Wan S, Jackson B, Nguyen BY, Robertson M, Barr E, Wahl J, Greaves W. Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet. 2015 Oct 17;386(10003):1537-45. Bhamidimarri KR, Czul F, Peyton A, Levy C, Hernandez M, Jeffers L, Roth D, Schiff E, O’Brien C, Martin P. Safety, efficacy and tolerability of half-dose sofosbuvir plus simeprevir in treatment of Hepatitis C in patients with end stage renal disease. J Hepatol. 2015 Sep;63(3):763-5. Inker LA, Tighiouart H, Coresh J, Foster MC, Anderson AH, Beck GJ, Contreras G, Greene T, Karger AB, Kusek JW, Lash J, Lewis J, Schelling JR, Navaneethan SD, Sondheimer J, Shafi T, Levey AS. GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD. Am J Kidney Dis. 2016 Jan;67(1):40-8. Munoz Mendoza J, Arramreddy R, Schiller B. Dialysate Sodium: Choosing the Optimal Hemodialysis Bath. Am J Kidney Dis. 2015 Oct;66(4):710-20 Suarez JF, Rosa R, Lorio MA, Morris MI, Abbo LM, Simkins J, Guerra G, Roth D, Kupin WL, Mattiazzi A, Ciancio G, Chen LJ, Burke GW, Goldstein MJ, Ruiz P, Camargo JF. Pre-transplant CD4 count influences immune reconstitution and risk of infectious complications in HIV(+) kidney allograft recipients. Am J Transplant. 2016 Mar 8. doi: 10.1111/ajt.13782. [Epub ahead of print] Still CH, Craven TE, Freedman BI, Van Buren PN, Sink KM, Killeen AA, Bates JT, Bee A, Contreras G, Oparil S, Pedley CM, Wall BM, White S, Woods DM, Rodriguez CJ, Wright JT Jr; SPRINT Study Research Group. Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial. J Am Soc Hypertens. 2015 Sep;9(9):670-9 Lugo-Baruqui JA, Guerra G, Chen L, Burke GW, Gaite JA, Ciancio G. Living donor renal transplantation with incidental renal cell carcinoma from donor allograft. Transpl Int. 2015 Sep;28(9):1126-30.

PEGGY AND HAROLD KATZ FAMILY DRUG DISCOVERY CENTER Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. Pedigo C, Ducasa GM, Leclercq F, Sloan A, Mitrofanova A, Hashmi T, MolinaDavid J, Ge M, Lassenius MI, Forsblom C, Letho M, Grop PH, Kretzler M, Eddy S, Martini S, Reich H, Wahl P, Ghiggeri GM, Faul C, Burke GW, Kretz O, Huber T, Mendez AJ, Merscher S, Fornoni A. JCI, In press. Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, Li J, Shehadeh LA, Hare JM, David V, Martin A, Fornoni A, Di Marco GS, Kentrup D, Reuter S, Mayer AB, Pavenstädt H, Stypmann J, Kuhn C, Hille S, Frey N, Leifheit-Nestler M, Richter B, Haffner D, Abraham R, Bange J, Sperl B, Ullrich A, Brand M, Wolf M, Faul C. Cell Metab. 2015 Dec 1;22(6):1020-32. PMID: 26437603 Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor. Villarreal R, Mitrofanova A, Maiguel D, Morales X, Jeon J, Grahammer F, Leibiger IB, Guzman J, Fachado A, Yoo TH, Busher Katin A, Gellermann J, Merscher S, Burke GW, Berggren PO, Oh J, Huber TB, Fornoni A. J Am Soc Nephrol. 2016 Apr;27(4):1029-41. PMID: 26400569 Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park JK, Staggs L, Haller H, Erschow S, Hilfiker-Kleiner D, Wei C, Chen C, Tardi N, Hakroush S, Selig MK, Vasilyev A, Merscher S, Reiser J, Sever S. Nat Med. 2015 Jun;21(6):601-9. PMID: 25962121 Drug discovery in focal and segmental glomerulosclerosis. Pullen N, Fornoni A. Kidney Int. 2016 Jun;89(6):1211-20. PMID: 27165834 Systemic and renal lipids in kidney disease development and progression. Wahl P, Ducasa GM, Fornoni A. Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F43345. Review.PMID: 26697982

Complete Remission in the Nephrotic Syndrome Study Network. Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson PJ, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova O, Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley KV, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, Mokrzycki MH, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M. Clin J Am Soc Nephrol. 2016 Jan 7;11(1):81-9. PMID: 26656320 Nonimmunologic targets of immunosuppressive agents in podocytes. Yoo TH, Fornoni A. Kidney Res Clin Pract. 2015 Jun;34(2):69-75. PMID: 26484025 CTLA4-Ig in B7-1-positive diabetic and non-diabetic kidney disease. Bassi R, Fornoni A, Doria A, Fiorina P. Diabetologia. 2016 Jan;59(1):21-9. PMID: 26409459 Editorial: current perspectives in diabetes and transplantation. Fornoni A, Vendrame F.Curr Diabetes Rev. 2015;11(3):134. PMID: 26013474 Rituximab in Children with Steroid-Dependent Nephrotic Syndrome: A Multicenter, Open-Label, Noninferiority, Randomized Controlled Trial. Ravani P, Rossi R, Bonanni A, Quinn RR, Sica F, Bodria M, Pasini A, Montini G, Edefonti A, Belingheri M, De Giovanni D, Barbano G, Degl’Innocenti L, Scolari F, Murer L, Reiser J, Fornoni A, Ghiggeri GM. J Am Soc Nephrol. 2015 Sep;26(9):2259-66. PMID: 25592855 The role of fibroblast growth factor 23 and Klotho in uremic cardiomyopathy. Grabner A, Faul C. Curr Opin Nephrol Hypertens. 2016 Jul;25(4):314-24. PMID: 27219043. Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease. Leifheit-Nestler M, Große Siemer R, Flasbart K, Richter B, Kirchhoff F, Ziegler WH, Klintschar M, Becker JU, Erbersdobler A, Aufricht C, Seeman T, Fischer DC, Faul C, Haffner D. Nephrol Dial Transplant. 2015 Dec 17. pii: gfv421. PMID: 26681731 Hunt for the culprit of cardiovascular injury in kidney disease. Faul C, Wolf M. Cardiovasc Res. 2015 Nov 1;108(2):209-11. PMID: 26395966 Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek J, Hill K, Shelton J, Amaral AP, Faul C, Taniguchi M, Wolf M, Brand M, Takahashi M, Kuro-O M, Hill JA, Moe OW. J Am Soc Nephrol. 2015 Jun;26(6):1290-302. PMID: 25326585

PULMONARY, CRITICAL CARE, ALLERGY AND SLEEP MEDICINE Semaan RW, Hazbon MP, Arias SA, Lerner AD, Yarmus LB, Feller-Kopman DJ, Lee HJ. Academic Productivity of Interventional Pulmonology Training Programs. Ann Am Thorac Soc. 2016 Apr;13(4):536-9. Yarmus LB, Arias S, Feller-Kopman D, Semaan R, Wang KP, Frimpong B, Oakjones Burgess K, Thompson R, Chen A, Ortiz R, Lee HJ. Electromagnetic navigation transthoracic needle aspiration for the diagnosis of pulmonary nodules: a safety and feasibility pilot study. J Thorac Dis. 2016 Jan;8(1):186-94. Yarmus L, Semaan R, Arias S, Feller-Kopman D, Ortiz R, Bösmüller H, Illei P, Frimpong B, Oakjones-Burgess K, Lee H. A Randomized Controlled Trial of a Novel Sheath Cryoprobe for Bronchoscopic Lung Biopsy in a Porcine Model. Chest. 2016 Jan 30. pii: S0012-3692(16)00512-2. Arias S, Yarmus L, Argento AC. Navigational transbronchial needle aspiration, percutaneous needle aspiration and its future. J Thorac Dis. 2015 Dec;7(Suppl 4):S317-28. Yarmus L, Akulian J, Ortiz R, Thompson R, Oakjones-Burgess K, Arias S, Semaan R, Feller-Kopman D, Lee H, Wang KP.A randomized controlled trial evaluating airway inspection effectiveness during endobronchial ultrasound bronchoscopy. J Thorac Dis. 2015 Oct;7(10):1825-32. Liu Q, Han S, Arias S, Turner JF, Lee H, Browning R, Wang KP. Efficacy and adequacy of conventional transbronchial needle aspiration of IASLC stations 4R, 4L and 7 using endobronchial landmarks provided by the Wang nodal mapping system in the staging of lung cancer. Thorac Cancer. 2016 Jan;7(1):118-22 Xia Y, Ma Y, Arias S, Lee H, Wang KP. Utilization of the International Association for the Study of Lung Cancer and Wang’s nodal map for the identification of mediastinum and hilar lymph nodes. Thorac Cancer. 2015 Jul;6(4):464-8.

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Department Publications Arias S, Semaan R, Lee H, Molena D, Feller-Kopman D, Yarmus L. Tridimensional Medical Thoracoscopy. Ann Am Thorac Soc. 2015 Jun;12(6):945-7 Sandhaus RA, Turino G, Brantly M, Campos M, Cross C, Goodman K, Hogarth K, Knight S, Stocks J, Stoller JK, Strange C, Teckman J. Clinical Practice Guideline: The Diagnosis and Management of Alpha-1 Antitrypsin Deficiency in the Adult. J COPD Foundation 2016; 3(3) In Press Fernandez M, Riveros JD, Campos M, Mathee K, Narasimhan G. Microbial “social” networks. BMC Genomics. 2015 Nov 10;16( Suppl 11):S6. Foronjy R.F., Salathe M., Dabo A.J., Baumlin N., Cummins N., Eden E., and Geraghty P. TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice. Am. J. Physiol - Lung Cell Mol. Physiol. 2016; in press Baumlin N., Salathe M., Fregien N. Optimal lentivirus production and cell culture conditions necessary to successfully transduce primary human bronchial epithelial cells. JoVE 2016 in press. Corral J.E., Dye C.W., Mascarenhas M.R., Barkin J.S., Salathe M., and Moshiree B. Is Gastroparesis Found More Frequently in Patients with Cystic Fibrosis? A Systematic Review. Scientifica 2016; 2016: Article ID 2918139, doi:10.1155/2016/2918139 Krick S., Wang J., St-Pierre M., Gonzalez C., Dahl G., and Salathe M. Duox2 Regulates Pannexin1-mediated ATP Release in Primary Human Airway Epithelial Cells via changes in intracellular pH and not H2O2 production. J. Biol. Chem. 2016; 291: 6423-32. PMCID: PMC4813552 Ivonnet P., Unwalla H., Salathe M. and Conner G.E. Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function. Respir. Res. 2016 17(1): 15. PMCID: PMC4746823 Foronjy R.F., Ochieng P.O., Salathe M.A., Dabo A.J., Eden E., Baumlin N., Cummins N., Barik S., Campos M., Thorp E.B. and Geraghty P. Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations. Mucosal Immunol. 2016 Jan 27. doi: 10.1038/mi.2015.138. Kis A., Krick S., Baumlin N., and Salathe M. Airway hydration, apical K+ secretion and the large conductance, Ca2+ activated and voltage-dependent potassium (BK) channel. Ann. Am. Thorac. Soc. 2016;13 Suppl 2: S163-8. Barr R.G., Avilés-Santa L., Davis S.M., Aldrich T., Gonzales F., Henderson A.G., Kaplan R.C., LaVange L., Liu K., Loredo J.S., Mendes E.S., Ni A., Ries A., Salathe M., Smith L.J. Pulmonary Disease and Age at Immigration among Hispanics: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/ SOL). Am. J. Respir. Crit. Care Med. 2016; 193: 386-95. PMCID: PMC4803083 Schmid A., Baumlin N., Ivonnet P., Dennis J.S., Campos M., Krick S., Salathe M. Roflumilast partially reverses smoke-induced mucociliary dysfunction. Respir. Res. 2015;16:135. doi: 10.1186/s12931-015-0294-3. PMCID: PMC4628339 Manzanares D., Krick S., Baumlin N., Dennis J.S., Tyrrell J., Tarran R., and Salathe M. Airway Surface Dehydration by Growth Factor TGF- in Cystic Fibrosis is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone. J. Biol. Chem. 2015; 290: 25710-6. PMCID: PMC4646213

Ivonnet P., Salathe M., and Conner G.E. Hydrogen Peroxide Stimulation of CFTR Reveals an EPAC-Mediated, Soluble Adenylyl Cyclase Dependent cAMP Amplification Pathway Common to GPCR Signaling. Br. J. Pharmacol. 2015; 172: 173-84. PMCID: PMC4280976 Unwalla H., Ivonnet P., Dennis J.S., Conner G.E., Salathe M. TGF-1 and cigarette smoke inhibit the ability of β2-agonists to enhance epithelial permeability. Am. J. Respir. Cell Mol. Biol. 2015; 52: 65-74. PMCID: PMC4370252 Fine LM, Bernstein JA. Urticaria Guidelines: Consensus and Controversies in the European and American Guidelines. Current Allergy and Asthma Reports. Curr Allergy Asthma Rep. 2015 Jun;15(6):30. doi: 10.1007/s11882-015-0535-z. Rubio GA, Elliot SJ, Glassberg MK. What Should Be Chronic: The Animal, the Model, or Both? Stem Cells Transl Med. 2016 May;5(5):703. doi: 10.5966/ sctm.2015-0325. Nathan SD, Albera C, Bradford WZ, Costabel U, du Bois RM, Fagan EA, Fishman RS, Glaspole I, Glassberg MK, Glasscock KF, King TE Jr, Lancaster L, Lederer DJ, Lin Z, Pereira CA, Swigris JJ, Valeyre D, Noble PW, Wells AU. Effect of continued treatment with pirfenidone following clinically meaningful declines in forced vital capacity: analysis of data from three phase 3 trials in patients with idiopathic pulmonary fibrosis. Thorax. 2016 Mar 11. pii: thoraxjnl-2015-207011. doi: 10.1136/thoraxjnl-2015-207011. Lancaster L, Albera C, Bradford WZ, Costabel U, du Bois RM, Fagan EA, Fishman RS, Glaspole I, Glassberg MK, King TE Jr, Lederer DJ, Lin Z, Nathan SD, Pereira CA, Swigris JJ, Valeyre D, Noble PW. Safety of pirfenidone in patients with idiopathic pulmonary fibrosis: integrated analysis of cumulative data from 5 clinical trials. BMJ Open Respir Res. 2016 Jan 12;3(1):e000105. doi: 10.1136/ bmjresp-2015-000105. Noble PW, Albera C, Bradford WZ, Costabel U, du Bois RM, Fagan EA, Fishman RS, Glaspole I, Glassberg MK, Lancaster L, Lederer DJ, Leff JA, Nathan SD, Pereira CA, Swigris JJ, Valeyre D, King TE Jr. Pirfenidone for idiopathic pulmonary fibrosis: analysis of pooled data from three multinational phase 3 trials. Eur Respir J. 2016 Jan;47(1):243-53. doi: 10.1183/13993003.00026-2015. Tashiro, JT, Elliot SE, Glassberg MK. Therapeutic benefits of young, but not old, adipose-derived mesenchymal stem cells in a chronic mouse model of bleomycin-induced pulmonary fibrosis. Transl Res. 2015 Dec;166(6):554-67. doi: 10.1016/j.trsl.2015.09.004. Lederer DJ, Bradford WZ, Fagan EA, Glaspole I, Glassberg MK, Glasscock KF, Kardatzke D, King TE Jr, Lancaster LH, Nathan SD, Pereira CA, Sahn SA, Swigris JJ, Noble PW. Sensitivity Analyses of the Change in FVC in a Phase 3 Trial of Pirfenidone for Idiopathic Pulmonary Fibrosis. Chest. 2015 Apr 9. doi: 10.1378/ chest.14-2817. Miller SA, Glassberg MK, Ascherman DP. Pulmonary complications of inflammatory myopathy. Rheum Dis Clin North Am. 2015 May;41(2):249-62. doi: 10.1016 / j.rdc.2014.12.006. Epub 2015 Feb 27. Review.

Kuenzi L., Krapf M., Daher N., Dommen J., Jeannet N., Schneider S., Platt S., Slowik J., Baumlin N., Salathe M., Prévôt A., Kalberer M., Straehl C., Dümbgen L., Sioutas C., Baltensperger U., and Geiser M. Toxicity of aged gasoline exhaust particles to normal and diseased airway epithelia. Sci. Rep. 2015: Jun 29;5:11801. doi: 10.1038/srep11801 PMCID: PMC4484354

Catanuto P, Tashiro J, Rick FG, Sanchez P, Solorzano CC, Glassberg MK, Block NL, Lew JI, Elliot SJ, Schally AV. Expression of Receptors for Pituitary-Type Growth Hormone-Releasing Hormone (pGHRH-R) in Human Papillary Thyroid Cancer Cells: Effects of GHRH Antagonists on Matrix Metalloproteinase-2. Horm Cancer. 2015 Jun;6(2-3):100-6. doi: 10.1007/s12672-015-0217-2. Epub 2015 Mar 10. PMID: 25752763

Jeannet N., Fierz M., Schneider S., Künzi L., Baumlin N., Salathe M., Burtscher H. and Geiser M. Acute toxicity of silver and carbon nanoaerosols to normal and cystic fibrosis human bronchial epithelial cells. Nanotechnology 2015: 26:1-13.

De La Cuesta C, DelRio J, Kett DH. Hospital Acquired MRSA Pneumonia: Diagnosis and Treatment. Textbook of Respiratory and Critical Care Infections. 2015..JAYPEE The Health Science Publishers. London

Bonser L.R., Schroeder B.W., Ostrin L.A., Baumlin N., Olson J.L., Salathe M., and Erle D.J. The ER resident protein AGR3 is required for regulation of ciliary beat frequency in the airway. Am. J. Respir. Cell Mol. Biol. 2015; 53: 536-43. PMCID: PMC4742895

Shimose LA, Masuda E, Sfeir M, Bernal-Caban A, Bueno MX, DePascale D, Spychala CN, Cleary T, Namias N, Kett DH, Doi Y, Munoz-Price LS. CarbapenemResistant Acinetobacter baumannii: Concomitant Contamination of Air and Environmental Surfaces. Infect Control Hosp Epidemiol. 2016 Apr 5:1-5. PMID: 27045768

Cancado J., Mendes E.S., Arana J., Horvath G., Monzon M.E., Salathe M., Wanner A. Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol. BMC Pharmacology and Toxicology 2015; Apr 2;16:9. doi: 10.1186/s40360-015-0008-y. PMCID: PMC4384333.

Quittner A., O’Donnell A., Salathe M.A., Lewis S., McKevitt M., Li X., Montgomery A.B., O’Riordan T., Barker A. Quality of Life QuestionnaireBronchiectasis: Final Psychometric Analyses and Determination of Minimal Important Difference Scores. Thorax 2015; 70: 12-20.

Berebichez- Fridman R, Deutsch YE, Joyal T, Olvera PM, Benedetto PW, Rosenberg A, Kett DH. Stewart-Treves Syndrome: A case report and review of the literature. Case Rep Oncol. 2016 Apr 1;9(1):205-11. doi: 10.1159/000445427.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Shimose LA, Doi Y, Bonomo RA, DePascale D, Viau RA, Cleary T, Namias N, Kett DH, Munoz-Price LS. Contamination of Ambient Air with Acinetobacter baumannii on Consecutive Inpatient Days. J Clin Microbiol. 2015 doi: 10.1128/ JCM.00198-15. Williams C, McGraw P, Schneck EE, LaFae A, Jacob JT, Moreno D, Reyes K, Cubillos GF, Kett DH, Estrella R, Morgan DJ, Harris AJ, Drees M. Impact of Universal Gowning and Gloving on Health Care Worker Clothing Contamination. Infect Control Hosp Epidemiol. 2015; 36:431-7. doi: 10.1017/ ice.2014.75. Mirsaeidi M, Motahari H, Taghizadeh Khamesi M, Sharifi A, Campos M, Schraufnagel DE. Climate Change and Respiratory Infections. Ann Am Thorac Soc. 2016 Jun 14. [Epub ahead of print] Mirsaeidi M, Gidfar S, Vu A, Schraufnagel D. Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis. J Transl Med. 2016 Apr 12;14:89. doi: 10.1186/s12967-016-0843-7. Review. Mirsaeidi M, Banoei MM, Nienow CK, Abassi T, Hakim A, Schraufnagel D, Winston BW, Sweiss N, Baughman R, Garcia JG, Machado R. Plasma metabolomic profile in fibrosing pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2016 Mar 29;33(1):29-38. Omar HR, Mirsaeidi M, Mangar D, Camporesi EM. Duration of ECMO is an independent predictor of intracranial hemorrhage occurring during ECMO support. ASAIO J. 2016 Mar 14. [Epub ahead of print] Hajimiri ES, Masoomi M, Ebrahimzadeh N, Fateh A, Hadizadeh Tasbiti A, Rahimi Jamnani F, Bahrmand AR, Mirsaeidi M, Vaziri F, Siadat SD. High prevalence of Mycobacterium tuberculosis mixed infection in the capital of moderate tuberculosis incidence country. Microb Pathog. 2016 Apr;93:213-8. doi: 10.1016/j.micpath.2016.02.015. Epub 2016 Mar 2. Hashemi-Shahraki A, Heidarieh P, Bostanabad SZ, Hashemzadeh M, Feizabadi MM, Schraufnagel D, Mirsaeidi M. Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis. Sci Rep. 2015 Dec 7;5:17862. doi: 10.1038/srep17862. Omar HR, Mirsaeidi M, El-Khabiry E, Mangar D, Camporesi EM. The simultaneous recording of right- and left-sided electrocardiogram in acute pulmonary embolism. Am J Emerg Med. 2016 Jun;34(6):1183.e5-7. doi: 10.1016/j.ajem.2015.11.018. Epub 2015 Nov 10. Mirsaeidi M, Banoei MM, Winston BW, Schraufnagel DE. Reply: Metabolomics and Mycobacterial Disease: Donâ&#x20AC;&#x2122;t Forget the Bioinformatics. Ann Am Thorac Soc. 2016 Jan;13(1):142-3. doi: 10.1513/AnnalsATS.201510-711LE. Omar HR, Mirsaeidi M, Shumac J, Enten G, Mangar D, Camporesi EM. Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. J Crit Care. 2016 Apr;32:48-51. doi: 10.1016/j.jcrc.2015.11.009. Epub 2015 Dec 2. Heidarieh P, Mirsaeidi M, Hashemzadeh M, Feizabadi MM, Bostanabad SZ, Nobar MG, Hashemi Shahraki A. In Vitro Antimicrobial Susceptibility of Nontuberculous Mycobacteria in Iran. Microb Drug Resist. 2016 Mar;22(2):1728. doi: 10.1089/mdr.2015.0134. Epub 2015 Oct 15. Mirsaeidi M, Allen MB, Ebrahimi G, Schraufnagel D. Hospital costs in the US for pulmonary mycobacterial diseases. Int J Mycobacteriol. 2015 Sep;4(3):217-221.

D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

Mirsaeidi M, Banoei MM, Winston BW, Schraufnagel DE. Metabolomics: Applications and Promise in Mycobacterial Disease. Ann Am Thorac Soc. 2015 Sep;12(9):1278-87. doi: 10.1513/AnnalsATS.201505-279PS. Review. Mirsaeidi M, Farnia P, Sadikot R, Hsueh PR, Aliberti S. Nontuberculous Mycobacteria: Epidemiologic, Mycobacteriologic, and Clinical Aspects. Biomed Res Int. 2015;2015:523697. doi: 10.1155/2015/523697. Epub 2015 Jun 16. Mirsaeidi M, Sadikot RT. Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis. Int J Mycobacteriol. 2015 Jun;4(2):92-96. Shamaei M, Mirsaeidi M, Baghaei P, Mosaei H, Marjani M, Tabarsi P. Recurrent Drug-Induced Hepatitis in Tuberculosis-Comparison of Two Drug Regimens. Am J Ther. 2015 May 5. [Epub ahead of print] Shafazand S. Sleep Disordered Breathing in Patients Chronically Using Opioids. UpToDate 2016 Shafazand S, Badr S. Commentary: Adaptive Servo-Ventilation and Central Apnea Associated with Systolic Heart Failure. J Clin Sleep Med 2016: 12(1) Mendes ES, Cadet L, Arana J, Wanner A. Acute Effect of an inhaled glucocorticosteroid on albuterol-induced bronchodilation in patients with moderately severe asthma. Chest 2015; 147:1037-42 Wanner A, Croft SC, Teagarden JR, et al. Clinical trial design for alpha-1 antitrypsin deficiency: A model for rare diseases. J COPD F 2015; 2:177-190

RHEUMATOLOGY Travers TS, Harlow L, Rosas IO, Gochuico BG, Bhattacharya SK, Camacho CJ, and Ascherman DP. Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes, J Immunol, in press. Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1403-12. Carpintero MF, Martinez L, Fernandez I, Romero AC, Mejia C, Zang YJ, Hoffman RW, Greidinger EL. Diagnosis and risk stratification in patients with anti-RNP autoimmunity. Lupus. 2015 Sep;24(10):1057-66. Kang EH, Lee SJ, Ascherman DP, Lee YJ, Lee EY, Lee EB, Song YW. Temporal relationship between cancer and myositis identifies two distinctive subgroups of cancers: impact on cancer risk and survival in patients with myositis. Rheumatology (Oxford). 2016 May 31. pii: kew215. [Epub ahead of print] PMID: 27247435 Aggarwal R, Oddis CV, Goudeau D, Koontz D, Qi Z, Reed AM, Ascherman DP, Levesque MC. Autoantibody levels in myositis patients correlate with clinical response during B cell depletion with rituximab. Rheumatology (Oxford). 2016 Jun;55(6):991-9. Reed AM, Crowson CS, Hein M, de Padilla CL, Olazagasti JM, Aggarwal R, Ascherman DP, Levesque MC, Oddis CV; RIM Study Group. Biologic predictors of clinical improvement in rituximab-treated refractory myositis. BMC Musculoskelet Disord. 2015 Sep 17;16:257.

Philanthropy

B. J. Harrington Sr. Director of Advancement

The Department is honored and grateful for the support and generosity of our many loyal donors, who believe in the mission of academic healthcare. Gifts to support the department help advance medical science, develop new treatments and cures, train new generations of physician-scientists, and improve the health of those in Miami, South Florida and beyond. We extend our deepest thanks to those individuals, foundations and corporations who have made a significant impact through their profound generosity.

GRATEFUL PATIENT $818K BEQUEST FOR CARDIOLOGY RESEARCH While vacationing with her husband in Puerto Rico over 20 years ago, Barbara B. Johnson fell ill. Her late husband, Bill, an executive with American Telephone and Telegraph in New York arranged to have her airlifted to Miami for treatment. Originally, they thought she was having a heart attack. Fortunately for Barbara, her condition was diagnosed as atrial fibrillation by UM doctors, she fully recovered and lived a long life. Barbara recently passed

away, at the age of 91, and left a gift through her will as her way of saying “thank you” for the extraordinary care she received. The John W. and Barbara B. Johnson Endowed Memorial Fund will be used to support cardiology research in the Cardiovascular Division.

ISLAMORADA FISHING TOURNAMENT SUPPORTS CROHN’S & COLITIS With the proceeds from the 12th Annual Sabadell Keymorada Invitational Fishing Tournament totaling more than $685,000, Keymorada has raised nearly $6 million since its inception. All proceeds from the May 10-13th event benefited the UM Crohn’s and Colitis Center and the Crohn’s and Colitis Foundation of America. We are grateful to the dedicated families who work tirelessly throughout the year to ensure the success of this important event – Alicia (Co-chair) and Mitch Widom, Ellen and Glenn Widom, Ellen (Co-chair) and Steven Shapiro and Dora and Steven Rubin.

Left to right: 12th Annual Sabadell Keymorada Invitational Fishing Tournament Participants Flip Glassman, Dr. Maria Abreu, Lauren Wackenhut LoCascio and Aaron LoCascio

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

OTHER NEW FUNDS ESTABLISHED THROUGH GRATEFUL PATIENT GIFTS: Arrhythmia Research Fund Cystic Fibrosis PulmonaryRelated Disease Fund Heart Rhythm Fund International Structural Heart Disease Interventional Fellowship Fund International Education – Cardiovascular Research Fund Nanoparticle Immunotherapy Research Fund

Above: Dr. Marc Lippman, left, receives the 2016 award from Dr. Jamie Barkin. Right: Plaque honoring awardees hangs at the entrance

Percutaneous Coronary/ Structural Heart Disease Intervention Fund

to Chairman’s office

BARKIN/ROGERS MENTORING AWARD NAMED

WOLFSON FOUNDATION CONTINUES LEGACY OF GENEROSITY

Dr. Arvey Rogers, and his mentee of several decades ago, Dr. Jamie Barkin, have been exemplary role models for dozens of fellows over the years. With their joint gift, the Barkin/ Rogers Mentoring Award was named in honor of their legacy. Last year, the award was newly established to recognize a faculty member who is a teacher, scholar, and often friend, and who emphasizes the practice of science and the humanities, with a focus on suffering patients and their families. The first awardee was Dr. Barry J. Materson Professor Emeritus in the Division of Clinical Pharmacology in 2015, and the 2016 awardee was Dr. Marc Lippman, former Chairman of Medicine and Professor in the Division of Medical Oncology.

In February 2016, a total of $609,000 in funding was presented to the Miller School of Medicine by Jerri Wolfson and Arthur Hertz, trustees of the Mitchell Wolfson Sr. Foundation. Mr. Hertz is also a University of Miami trustee, and the gift continues an over 25-year history of support to UM from the foundation. It will support projects including the Center for Liver Diseases headed by Dr. Eugene Schiff of Hepatology, an international fellowship in interventional cardiology led by Dr. Eduardo de Marchena, and the Wolfson Department of Community Service (DOCS), through which students to provide health outreach to South Florida’s most underserved communities. Dr. Amar Deshpande of the Gastroenterology Division serves as the program’s faculty advisor.

Below: Mr. Arthur Hertz and Ms. Jerri Wolfson with the recipients of

Sleep Center Support Fund Thyroid Dysfunction Research Fund

$609,000 in support from the Mitchell Wolfson Sr. Foundation.

D epartmen t o f Medic in e C h air man ’s R e po r t 2016

Residents NAME

MEDICAL SCHOOL

YEAR

CATEGORICAL INTERNAL MEDICINE

Alhaqqan, Dalal M. A. M. A. Arriola, David Jonathon Bodager, Jonathan Carmenate, Gretel Maria Estes, Derek Jordan Frank, Brian Andrew Goldstein, Jordan Seth Granda, Michael Louis Gupta, Manik Kumar Haque, Tahir Hsu, Robert Chun-Hao Iordanov, Roumen Borilov Iupe, Isabella Khalafi, Seyed Mohammad Lee, Alexandra Mehta, Vijay Milisavljevic, Ana Missinne, Edward Emil Neuman, Danielle Rachel Obid, Samer Olarte, Neal I Pico, Brian Anthony Prudent, Dolores Pyarali, Fahim Firozali Rosen, Adam Michael Santillana, Elsa Cassandra Scheinberg, Andrew Ross Sedki, Mai Serna, Myrna Katalina Algaze, Sandra Bromante, Stephanie Brown, Kevin Byrnes, Diana Castellanos, Raul Catoe, Heath Cogorno, Mariela Dabas, Nitika Dauer, Ryan Dillon, David Fernandes, Marcelo Garner, Salih Gosine, Adhiraj Johnson, Shawntira Karantalis, Vasileios Keihanian, Tara Kennedy, Rachel Lowery, Megan Parmar, Rajiv Pereira, Reginald Pontee, Nicole Rivner, Harold Rodriguez, Gracielena Schmidtman, Jenna Smith, Lauren Taldone, Sabrina Al Sharhan, Loulwa Ashukem, Moses Badlani, Jayshiv Brice, Aaron Chapman, Ryan Diaz, Carlos Henderson, Armen Kirolos, Irene Laderian, Bahar Mason, Ajani Morel, Charlotte Muenyi, Valery Nguyen, Nhi 44

Kuwait University Faculty of Medicine Duke University School of Medicine Medical College of Wisconsin Florida International University Herbert Wertheim College of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Stony Brook University School of Medicine Eastern Virginia Medical School Ponce Health Sciences University School of Medicine Morehouse School of Medicine Tulane University School of Medicine University of Miami Leonard M. Miller School of Medicine Louisiana State University School of Medicine in Shreveport University of Missouri-Kansas City School of Medicine Florida International University Herbert Wertheim College of Medicine The University of Toledo College of Medicine Vanderbilt University School of Medicine Morehouse School of Medicine University of Miami Leonard M. Miller School of Medicine George Washington University School of Medicine and Health Sciences University of North Texas Health Science Center at Fort Worth/Texas College of Osteopathic Medicine University of Illinois College of Medicine George Washington University School of Medicine and Health Sciences University of Texas Medical Branch School of Medicine University of Miami Leonard M. Miller School of Medicine Nova Southeastern University College of Osteopathic Medicine University of Miami Leonard M. Miller School of Medicine Wayne State University School of Medicine Baylor College of Medicine Universidad Central del Caribe School of Medicine Nova Southeastern University College of Osteopathic Medicine Chicago Medical School at Rosalind Franklin University of Medicine & Sciences University of Miami Leonard M. Miller School of Medicine Florida State University College of Medicine University of Miami Leonard M. Miller School of Medicine Universidad Central de Venezuela Escuela de Medicina Luis Razetti University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Charles E. Schmidt College of Medicine at Florida Atlantic University Duke University School of Medicine Howard University College of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Patras School of Health Sciences Tehran University of Medical Sciences University of Miami Leonard M. Miller School of Medicine Temple University School of Medicine University of Texas Southwestern Medical Center University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Medical College of Georgia University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Howard University College of Medicine University of Miami Leonard M. Miller School of Medicine Kuwait University Virginia Commonwealth University School of Medicine University of Pittsburgh School of Medicine University of Virginia School of Medicine Nova Southeastern University College of Osteopathic Medicine Rush Medical College of Rush University School of Medicine Meharry Medical College Misr University for Science and Technology University of Pittsburg School of Medicine Howard University College of Medicine New York Medical College Meharry Medical College Washington University in St. Louis School of Medicine

PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Residents NAME

MEDICAL SCHOOL

YEAR

Puig, Enrique Saravia, Diana Scherfenberg, Naomi Schwartz, Marc Thekkumkattil, Anu Tookes, Hansel Vitolo, Melissa Watford, Daniel Wu, Grace

Ponce School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine The School of Medicine at Stony Brook University Medical Center University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Jefferson Medical College of Thomas Jefferson University University of North Carolina at Chapel Hill School of Medicine University of Illinois at Chicago College of Medicine

PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3

PRELIMINARY YEAR

Ball, John Franklin Cavallin, Lucas Edgardo Damanpour, Shadi Faulconer, Nicholas Fox, Bradley Ross Fox, Joshua Davyd Kodiyan, Joyson Ortiz, Angelica Gabriela Siegmeister, Jerome Aron Stoffers, Kyle Clark Velamuri, Sriram Williamson, Stacey Alese

University of Mississippi School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Texas Southwestern Medical Center Southwestern Medical School George Washington University School of Medicine and Health Sciences University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine USF Health Morsani College of Medicine University of Cincinnati College of Medicine

PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1

CATEGORICAL INTERNAL MEDICINE - HOLY CROSS HOSPITAL

Blau, Ira, Gandhi, Priya Goswamy, Juhi Guarch, Gerardo Ilaiwy, Amro Karanam, Chandana Lozier, Matthew Pineda, Kritzia Quintero Betancourt, Javier Rasha, Shimika Sahni, Neil Worme, Amanda Adkinson, Brian Cody Akkineni, Sisir Bustos, Mario Clemons, Shannon Farsi, Salman Jordan, Karina Nair, Abhishek Neuman Guerra, Patricia Prevatt, Opal Rosa, Vanessa Sennhauser, Susie Simonait, Michelle Bdair, Hazem Bebars, Hosameldin Bunney, Alan Casey, Monet Elfituri, Amin Fraga Braghiroli, Naiara Howard-Jones, Jametria Lee, John Lopez, Eduardo Patel, Hardik Puig, Sebastian Ramreddy, Nitya

Medical College of Wisconsin University of Texas School of Medicine at San Antonio University of Miami Leonard M. Miller School of Medicine Xavier University School of Medicine, Aruba University of Damascus Faculty of Medicine Sri Venkateswara Medical College Wayne State University School of Medicine Universidad de Medicina San Juan Bautista School of Medicine Sylhet M.A.G. Osmani Medical College George Washington University School of Medicine and Health Sciences University of the West Indies, Barbados Faculty of Medical Sciences Wright State University Boonshoft School of Medicine P.S.G. Institute of Medical Sciences and Research Universidad Militar Nueva Granada Facultad de Medicina Meharry Medical College Florida International University Herbert Wertheim College of Medicine Ponce School of Medicine and Health Sciences Jubilee Mission Medical College and Research Institute San Juan Bautista School of Medicine University of Virginia School of Medicine Ponce School of Medicine and Health Sciences Charles E. Schmidt College of Medicine at Florida Atlantic University Wayne State University School of Medicine An-Najah National University Faculty of Medicine and Health Sciences Ain Shams University Wayne State University University of Tennessee University of Tripoli Faculty of Medicine Faculdade de Medicina de Bahia, Universidade Federal da Bahia (UFBA) University of Miami Leonard M. Miller School of Medicine Chicago Medical School at Rosalind Franklin University USF Health Morsani College of Medicine Pramukhswami Medical College University of Florida Mediciti Institute

PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3

PRELIMINARY YEAR - HOLY CROSS HOSPITAL

Bishop, Brian Bray, Fleta Gayou, Edward Rosa, Ashley Singh, Gaurav Woodley, Naomi

University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine

D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

PGY1 PGY1 PGY1 PGY1 PGY1 PGY1

Residents NAME

MEDICAL SCHOOL

YEAR

Drexel University College of Medicine Loma Linda University School of Medicine University of Miami Leonard M. Miller School of Medicine Meharry Medical College Louisiana State University Health Sciences Center University of Miami Leonard M. Miller School of Medicine Medical College of Georgia Regents University University of Pittsburg School of Medicine University of Iowa Roy J. Lucille A. Carver College of Medicine University of Pittsburg School of Medicine Indiana University School of Medicine Georgetown University School of Medicine University of Arkansas for Medical Sciences College of Medicine University of Colorado School of Medicine University of Chicago Pritzker School of Medicine Ponce School of Medicine and Health Sciences University of Pittsburgh School of Medicine University of Colorado Denver School of Medicine Stony Brook University School of Medicine Howard University College of Medicine

PGY1 PGY1 PGY1 PGY1 PGY1 PGY2 PGY2 PGY2 PGY2 PGY2 PGY3 PGY3 PGY3 PGY3 PGY3 PGY4 PGY4 PGY4 PGY4 PGY4

University of Puerto Rico School of Medicine Universidade Federal Fluminense Ross University School of Medicine Georgetown University School of Medicine Sidney Kimmel Medical College at Thomas Jefferson University University of Oklahoma College of Medicine at Oklahoma City University of Miami Leonard M. Miller School of Medicine New York Medical College Indiana University School of Medicine

PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1

MEDICINE - PEDIATRICS

Chery, Stephanie Diambois, Vanessa Ediriweera, Hasini Odoms, La’Nyia Wolfe, Amy Botros, Diana Brandon, Theodora Jimenez-Bacardi, Adria Khidir, Hana Lott, Margaret Flowers, Chad Petrauskis, Christian Saxena, Anjali Schneider, Jessica Thorngren, Daniel Gonzalez, Samantha Meza, Benjamin Park, Jane Parris, Brent Van Kirk, Kendra NEUROLOGY

Flores Gonzalez, Ramon Garbin Di Luca, Daniel Gonzalez, Lixandra Ibish, Abdullah Krementz, Nastajja Mannava, Sishir Oilu, Carlos Stiep, Tamara Yen, Jessica

WILLIAM J. HARRINGTON LATIN AMERICAN TRAINING PROGRAM

Caravedo, Maria Alejandra Carias Martinez, Karla G. Escobar Carrasquero, Luis A. Espejo Freire, Andrea Patricia Marmontel Nasi, Guilherme Mohammed, Sobrina Sarah Murman, Magdalena Saint Croix, Garly Rushler Zablah Regalado, Gerardo Jose Blumer, Vanessa Bravo, Gabriela Cortesi, Camile Costa Fernandes Filho, Gilson De La Cruz, Indhira Ibrahim, Michel Morillas Rodriguez, Jose Pacheco Cano, Carlos Rivera Maza, Manuel Sinanan, Rajiv Suarez, Jose Zavala, Bruno Chavez Morales, Efren Alejandro de la Cruz Luque, Celso Fernando Duque Ballesteros, Juan Camilo Dvorquez, Denise Kimble, Erik Lesley Lorio, Marco Malpica Castillo, Luis Enrique Mendirichaga, Rodrigo Monge Urrea, Jorge Nunez Breton, Jonatan David Pardinas Gutierrez, Miguel Agustin Pena Polanco, Nathalie Aurora

Universidad Peruana Cayetano Heredia Facultad de Medicina Alberto Hurtado Universidad Nacional Autonoma de Honduras Facultad de Ciencias Medicas Universidad Central de Venezuela Escuela de Medicina Jose Maria Vargas Universidad San Francisco de Quito Colegio de Ciencias de la Salud Universidade Federal do Rio Grande do Sul (UFRGS) Faculdade de Medicina University of the West Indies Faculty of Medicine St. Augustine, Trinidad Universidad Austral Facultad de Ciencas BiomÃ©dicas Université d’Etat d’Haiti Faculté de Médecine et de Pharmacie Universidad Nacional Autonoma de Honduras Facultad de Ciencias Medicas Universidad Central de Venezuela Escuela de Medicina Luis Razetti Universidad San Francisco de Quito Colegio de Ciencias de la Salud, Eucador Universidad del Desarrollo Facultad de Medicine, Sede Santiago, Chile Universidade Federal da Paraiba (UFPB) Centro de Ciencias Medicas, Brazil Instituto Technologico de Santo Domingo (INTEC) Facultad de Salud Universidad Iberoamericana (UNIBE) School of Medicine, Santo Domingo, Dominican Republic Universidad Nacional de Trujillo Facultad de Medicina, Peru Universidad del Mayab Escuela de Medicina, Mexico Universidad Dr. Jose Matias Delgado Escuela de Medicina, El Salvador University of the West Indies Faculty of Medicine St. Augustine, Trinidad Universidad de la Sabana Facultad de Medicina, Colombia Universidad Catolica Nuestra Senora de la Asuncion Facultad de Ciencias de la Salud, Asuncion, Paraguay Universidad Autonoma de Chihuahua, Mexico Universidad Peruana Cayetano Heredia, Peru Universidad de la Sabana, Colombia Universidad Catolica de Santiago de Guayaquil, Ecuador Universidad de Guadalajara, Mexico Universidad Nacional Autonoma de Nicaragua, Managua Universidad Peruana Cayetano Heredia, Peru Universidad de Moterrey, Mexico Universidad Anahuac, Mexico Pontificia Universidad Catolica Madre y Maestra (PUCMM),DR Westhill Institute, Mexico Pontificia Universidad Catolica Madre y Maestra (PUCMM),DR

PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY1 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY2 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3 PGY3

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Fellows NAME RESIDENCY

YEAR

CARDIOVASCULAR

Macon, Conrad Novoa, Italo Panakos, Andrew Perez, Sergio Ramireddy, Archana El Dassouki, Saleh (OOM) Elmahdy, Hany Agarwal, Zubin Alsulaimi, Ali Chongthmmakun, Vasukatakarn Emaminia, Abbas Gomez, Camilo Lucero, Thomas Patel, Nileshkumar Rodriguez, Alexis Braghiroli, Joao Elias, Elliott Hawk, Christopher Hernandez, Gabriel Mushtaq, Muzammil Patel, Nish Smairat, Ramez

Jackson Memorial Hospital/UM Jackson Memorial Hospital/UM Thomas Jefferson University Jackson Memorial Hospital/UM Jackson Memorial Hospital/UM UM/Palm Beach Regional Campus Mt Sinai Medical Center Miami Beach University of Vermont Jackson Memorial Hospital-Univ. of Miami Cleveland Clinic Foundation New York Medical College Valhalla Jackson Memorial Hospital-Univ. of Miami Jackson Memorial Hospital-Univ. of Miami Staten Island University Hospital Jackson Memorial Hospital-Univ. of Miami Jackson Memorial Hospital-Univ. of Miami Icahn School of Medicine at Mount Sinai, New York Columbia University Medical Center- New York Jackson Memorial Hospital-Univ. of Miami Mount Sinai School of Medicine, New York University of Oklahoma Health Sciences Center Jackson Memorial Hospital-Univ. of Miami

PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY5 PGY5 PGY5 PGY5 PGY5 PGY5 PGY5 PGY5 PGY6 PGY6 PGY6 PGY6 PGY6 PGY6 PGY6

CARDIOVASCULAR - ELECTROPHYSIOLOGY

Tovvia Brodie, Oholi

Tel-Aviv University, Israel

PGY7

CARDIOVASCULAR - INTERVENTIONAL

Cena, Marel Wojciech University of Texas, Galveston Medvedev, Ivan University of Washington, Seattle Narula, Arvin Drexel University College of Medicine, Philadelphia Structural Interventional Baquero, Giselle Pennsylvania State University

PGY7 PGY7 PGY7 PGY7

ENDOCRINOLOGY, DIABETES AND METABOLISM

Perez, Elys Al Yatama, Fatima Chertman, Lila Jara, Mark Zaleski, Megan Banga, Pritisheel Hannoush, Zeina Palacios Merchan, Juan

Pennsylvania Hosp. of the Univ. of Pennsylvania Health System Program Jackson Memorial Hospital/UM Mount Sinai Medical Center, Miami Beach, FL University at Buffalo, Buffalo, NY Cleveland Clinic Florida, Weston, FL UCSF Fresno, CA Jackson Memorial Hospital/UM University of Miami-Regional Campus

PGY 4 PGY4 PGY4 PGY4 PGY4 PGY5 PGY5 PGY5

GASTROENTEROLOGY

Dholoria, Kevin Diaz Urrutia, Liege Isabel Goyal, Jatinder Panara, Ami Sendzischew, Morgan Berera, Shivali Croteau, Ryan Donet, Jean Goel, Akash Kim, Su Bin Barkin, Jodie Calmet, Fernando Gosalia, Ashil Perlini, Erin Kalra, Gorav

Jackson Memorial Hospital/University of Miami Jackson Memorial Hospital/University of Miami University of Alabama at Birmingham Baylor College of Medicine Jackson Memorial Hospital/University of Miami Jackson Memorial Hospital-Univ. of Miami, FL Icahm School of Medicine Mt. Sinai, New York, NY Jackson Memorial Hospital-Univ. of Miami, FL Columbia University, New York, NY Albert Einstein College of Medicine, New York, NY Jackson Memorial Hospital-Univ. of Miami, FL Jackson Memorial Hospital-Univ. of Miami, FL Browne University, Rhode Island, RI Jackson Memorial Hospital-Univ. of Miami, FL Washington University, St. Louis, MO

PGY4 PGY4 PGY4 PGY4 PGY4 PGY5 PGY5 PGY5 PGY5 PGY5 PGY6 PGY6 PGY6 PGY6 PGY6

GERIATRICS

Aljabr, Qasem M. Cardenal Castro, Daniel Daniels, Brenda Figueroa, Janmary Indlamuri, Mastan Rao Kanthala, Abhijit Reddy Malhi, Tejbir Singh Sierra, Karen Tellechea, Carlos

Texas Health Science Center Texas Technical University Flushing Hospital Medical Center Hospital de la Concepcion San German, Puerto Rico Texas Health Science Center Unity Hospital- Rochester Regional Health Western Res. Health Ed./Northside Med. Ctr., Bella vista Hospital, Mayaguez, Puerto Rico Atlanta Medical Center, Atlanta, GA

D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 47

Fellows NAME RESIDENCY

YEAR

HEMATOLOGY-ONCOLOGY

Ali, Robert Florou, Vaia Gallastegui, Nicolas Palacios, Sofia Ramdial, Jeremy Torres, Alfredo Bradley, Terrence El Dinali, Mohamed Nahas, George Park, Wungki Salzberg, Matthew Alderuccio, Juan Desai, Amrita Sandoval, Ana Vargas, Fernando

University of Florida COM-J Rutgers Robert Wood Johnson Med. School/ Saint Peter’s Univ. Hosp. University of Miami / Jackson Memorial Hospital Jackson Memorial Hospital/UM Jackson Memorial Hospital/UM Jackson Memorial Hospital/UM NSLIJHS/Hofstra North Shore – LIJ School of Med. Weiss Memorial Hospital, Chicago, IL Rutgers University-New Jersey Medical School Mount Sinai St. Luke’s Roosevelt Hospitals Jackson Memorial Hospital-Univ. of Miami Metropolitan Hospital Center, NY Medical College Memorial Hospital of Rhode Island Jackson Memorial Hospital-Univ. of Miami Jackson Memorial Hospital-Univ. of Miami

PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY5 PGY5 PGY5 PGY5 PGY5 PGY6 PGY6 PGY6 PGY6

HEPATOLOGY

Thartwat Samuels, Maria

Mount Sinai Beth Israel

PGY7

Palmetto General Hospital, Hialeah, FL Cooper University Hospital, Camden, NJ Orlando Health Center, Orlando, FL University of Pittsburg Medical Center Jackson Memorial Hospital-Univ. of Miami Broward Health Jersey City Medical Center Wright State University, Dayton, OH, United States University of Florida – Jacksonville

PGY4 PGY4 PGY4 PGY5 PGY5 PGY5 PGY5 PGY5 PGY5

Jackson Memorial Hospital Kingsbrook Jewish Medical Center, Brooklyn, NY Orlando Health Center, Orlando, FL Elmhurst Hospital Center, NJ Jackson Memorial Hospital-Univ. of Miami Jackson Memorial Hospital-Univ. of Miami Jackson Memorial Hospital-Univ. of Miami

PGY4 PGY4 PGY4 PGY4 PGY5 PGY5 PGY5

Mount Sinai Medical Center - Miami Beach, Fl Jackson Memorial Hospital/University of Miami Pennsylvania Hospital, Philadelphia Cleveland Clinic, Weston, Fl Jackson Memorial Hospital-Univ. of Miami Yale/Griffin Hospital New Haven University of Miami-Regional Campus Jackson Memorial Hospital-Univ. of Miami Southern Illinois University School of Medicine Jackson Memorial Hospital-Univ. of Miami Virginia Commonwealth University Health System Jackson Memorial Hospital-Univ. of Miami University of Miami Miller School/Regional Campus Cleveland Clinic (Florida) Program Jackson Memorial Hospital/University of Miami

PGY4 PGY4 PGY4 PGY4 PGY5 PGY5 PGY5 PGY5 PGY5 PGY6 PGY6 PGY6 PGY6 PGY6 PGY7

Jackson Memorial Hospital/University of Miami Interfaith Medical Center, Brooklyn, NY Beth Israel, NYC Jackson Memorial Hospital-Univ. of Miami

PGY4 PGY4 PGY5 PGY5

INFECTIOUS DISEASES

Camps, Nicholas Cloke, Christina Nwanyanwu, Rita Anjan, Shweta Goldenberg, Vanessa Hall, Toni Rodriguez, Anamaria Rojas-Gomez, Juan Sternberg, Candice NEPHROLOGY

Armstrong, Antonio Jean, Henry Mendez Castaner, Lumen Ramos, Abraham Dejman, Adriana Kusnir, Juan Pagan, Javier PULMONARY-CRITICAL CARE

Ascher, Kori Khalid, Laiqua Nakayama, Ikue Perez, Yoslay Buryk, Yaroslav Choudhry, Bassam El Khatib, Ahmad Latibeaudiere, Rachel Wynn, Nikki Brito, Yoel Kwasnik, Aleksandra Miller, Shelly Sarmento, Bianca Schwartz, Randall Barahona, Luz CRITICAL CARE

Arciniegas Flores, Rafael Agustin Jadegondanahalli, Jai Prakash Babu Askari, Kyan Rico, Rene

RHEUMATOLOGY

Guzman Bosch, Lily Ruiz Irizarry, Yelliann Fernandez, Karen LaConti, Joseph

Damas Hospital Program, Ponce New York Methodist Hospital Jackson Memorial Hospital-Univ. of Miami Jackson Memorial Hospital-Univ. of Miami

PGY4 PGY4 PGY5 PGY5

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

UNIVERSITY OF MIAMI LEADERSHIP President: Julio Frenk, MD, MPH, PhD CEO, UHealth and SVP of Health Affairs: Steven Altschuler, MD Dean, Miller School of Medicine (through June 2016): Pascal Goldschmidt, MD Interim Dean, Miller School of Medicine: Laurence Gardner, MD, MACP

DEPARTMENT LEADERSHIP Chair: Roy Weiss, MD, PhD Vice Chair for Administration: Anna Carol Herman-Giddens, RN, BSN Vice Chair for Appointments, Promotion and Tenure: Jennifer Marks, MD Vice Chair for Clinical Affairs: Michael Kolber, MD Vice Chair for Education: Stefanie Brown, MD Vice Chair for Innovation and Diversity: Marilyn Glassberg, MD Vice Chair for Research: Matthias Salathe, MD Associate Vice Chair for VA Affairs: Thomas Hooton, MD Associate Vice Chair for Quality: Maritza Suarez, MD Executive Director, Clinical Operations: Carlos Prieto Executive Director, Finance: Andres P. Macia Director, Business Operations: Jennifer Y. Kim

DIVISION CHIEFS Cardiovascular: Jeffrey Goldberger, MD, MBA Clinical Pharmacology: Richard Preston, MD, MSPH, MBA Endocrinology, Diabetes and Metabolism: Ernesto Bernal-Mizrachi, MD Gastroenterology: Maria Abreu, MD General Internal Medicine: Olveen Carrasquillo, MD, MPH Geriatrics and Palliative Medicine: Olveen Carrasquillo, MD, MPH (Interim) Hematology: Joseph Rosenblatt, MD Hepatology: Paul Martin, MD Hospital Medicine: Efren Manjarrez, MD Infectious Diseases: Mario Stevenson, PhD Medical Oncology: Joseph Rosenblatt, MD (Interim) Nephrology and Hypertension: Oliver Lenz, MD, MBA (Interim) Population Health and Computational Medicine: David Seo, MD Pulmonary, Allergy, Critical Care and Sleep Medicine: Matthias Salathe, MD Rheumatology and Immunology: Eric Greidinger, MD

DIVISION ADMINISTRATION Cardiovascular: Cristina Baldor Endocrinology, Diabetes and Metabolism: Cristina Calderon-Parra Gastroenterology: Carol Cottrell General Internal Medicine: Sarah Quadri Geriatrics and Palliative Medicine: Jennifer LaPorta Hematology: Stephanie Reinoso Hepatology: Carol Cottrell Hospital Medicine: Jennifer LaPorta Infectious Diseases: Maria Piega Medical Oncology: Stephanie Reinoso Nephrology and Hypertension: Susan Martin Population Health and Computational Medicine: Michelle Hutarte Pulmonary, Allergy, Critical Care and Sleep Medicine: Rolando Briceno Rheumatology and Immunology: Jennifer LaPorta Special thanks to: Jennifer Y. Kim Office of Diversity and Inclusion University of Miami Biomedical Communications

D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2016

University of Miami Health System delivers leading-edge patient care by top-ranked physicians. Powered by the Miller School of Medicine’s groundbreaking research and medical education, UHealth provides life-saving care. UHealth is a comprehensive network of six hospitals, two dozen outpatient facilities, 1,200 doctors, and more than 8,000 associates. As the region’s only university health system, UHealth is a vital component of the South Florida community.

Department of Medicine, Chairman’s Office Don Soffer Clinical Research Center Leonard M. Miller School of Medicine University of Miami 1120 NW 14th Street, Suite 310 Miami, FL 33136 305.243.9120 medicine.med.miami.edu