Department of Medicine Annual Report 2019 by University of Miami Department of Medicine

MIAMI TEAM MEDICINE DEPARTMENT OF MEDICINE CHAIRMANâ&#x20AC;&#x2122;S REPORT 2019

TABLE OF CONTENTS

Chairâ&#x20AC;&#x2122;s Message

2 By the Numbers & Learner Demographics 3

TEAM MEDICINE: Four patients and their physicians tell how a team approach results in the best care

Division Highlights High Impact Publications Faculty and Administration Listing Philanthropy

Editor: Laura J. Pinzon Director, Business Operations

Photography: UM Biomedical Communications, Jenny Abreu

Design, Editorial & Project Management Consulting: Sabia Communications, Inc.

Feature Writer: Cristina Baldor

Published by the Chairman's Office of the Department of Medicine at the University of Miami Miller School of Medicine. All contents, ÂŠ2019 University of Miami. Reproduction in whole or in part without previous written permission by the editor is prohibited.

Chair’s Message Team Medicine is at the heart of what we do in the Department of Medicine at the University of Miami Miller School of Medicine. We coordinate the care of our patients and we collaborate through our investigative studies and the teaching of our future physicians. We call it the “Miami Team Medicine” way.

managers and other health care professionals come together in order to provide the very best care to our patients.

Our team approach makes sure our patients receive the personalized care they deserve and our learners become the next generation of leaders in medicine and healthcare. Just like the saying “it takes a village to raise a child,” it takes a team of highly trained physicians and staff to collaborate in order to enhance outcomes. Our discoveries at the bench, and when translated to improve the health of society, are also a product of Team Medicine.

Welcome to the 2019 Annual Report of the Department of Medicine.

We share four examples in this report portraying how a team-based approach has enhanced the quality of life of our patients and enabled us to accomplish our missions. You will see how physicians, scientists, nurses, advanced practice providers, pharmacists, social workers, case

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“Team Medicine” is the future of health care and as Chairman, I am proud the Department of Medicine is far ahead of the curve.

All my best,

Roy E. Weiss, MD, PhD Professor of Medicine Chair, Department of Medicine Kathleen & Stanley Glaser Distinguished Chair in Medicine Rabbi Morris I. Esformes Endowed Chair in Medicine and Endocrinology University of Miami Miller School of Medicine

By the Numbers CLINICAL ACTIVITY KEY FACTS

RESEARCH SPENDING FY18

FY19

Total Grants and Contracts in Millions of Dollars (3% increase over FY18)

% CHANGE

Net Patient Revenues................................ $54,497,991 .......................... $64,369,887............................... 18%

Work RVUs...................................................... 913,017 .............................. 1,029,040............................... 13%

Outpatient visits.............................................. 172,478 ................................. 189,447............................... 10%

Inpatient visits................................................ 151,897 ................................. 173,213............................... 14%

37 31 27

Procedures........................................................ 95,221 ................................ 108,772 .............................. 14%

New patient visits............................................. 37,866 ................................... 40,586................................ 7%

FACULTY

ETHNICITY %

White ................................................................ 48 Hispanic or Latino ............................................. 34 Asian or Pacific Islander..................................... 12

FY2016

FY2018

FY2019

62%

RESEARCH FUNDING SOURCES

FY19 Research Funding 12%

Federal Grants.......$ 19,156,961

Black or African American................................... 4

State Grants...............1,740,569

48%

American Indian.................................................. 1 Two or more ethnicities ...................................... 1

FY2017

Local Grants..................110,132

34%

Private Grants..........17,654,833

GENDER %

TOTAL.........................$ 38,662,495

Male.................................................................. 64 Female............................................................... 36

DIVISIONS GRANTS & CONTRACTS (% contribution of $39M) Expenditures FY19

Pop. Health & Comp. Med. 1%

36%

Rheumatology 1% Chairman Clinical 3% Pharm. Cardiovascular 6% 4%

Pulmonary Med. 8% Med. Oncology CC 13%

64%

Endo Diabetes 6%

Gastro 4%

Med. Oncology 4%

General Medicine 4%

Katz Center 2% Infectious Diseases 24%

Hematology CC 13%

Hematology 6%

Hepatology 1% 2

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MIAMI TEAM MEDICINE ”From disease discovery, to compassionate treatment, to training the next generation of medical leaders, the DOM leads by teamwork.” — Chair Dr. Roy E. Weiss

WHAT IS TEAM MEDICINE? At the University of Miami Department of Medicine, we strive to

Department of Medicine physicians and scientists are active in

accomplish our missions as a team. Although individual physicians

dozens of interdisciplinary teams, tackling conditions from Atrial

and scientists have specialties and expertise, we know people and

Fibrillation to the Zika Virus. This includes service lines such as the

their conditions are complex. Patients don’t fit into just one box

Cardiovascular Disease Center and the Digestive Health Center as

and the symptoms we treat don’t exist in a vacuum devoid of the

well as other institutes and centers in which our faculty participate:

influence of social determinants of health. Successful and impactful

• Braman Family Breast Cancer Institute

treatment requires the expertise of many to provide a holistic

• Center for AIDS Research (CFAR)

approach.

• Crohn’s and Colitis Center

The Team Medicine approach brings together a group of health

• Diabetes Research Institute

care providers and scientists with the goal of forming a plan of care

• Gordon Center for Research in Medical Education

or prevention that leads to the best outcome for the patient. “From

• HIV/AIDS Institute

disease discovery, to compassionate treatment, to training the next

• Institute for Bioethics and Health Policy

generation of medical leaders, the DOM leads by teamwork,” said

• Interdisciplinary Stem Cell Institute

Chair Dr. Roy Weiss.

• International Medicine Institute • Miami Clinical and Translational Science Institute • Miami Transplant Institute • Peggy and Harold Katz Family Drug Discovery Center • Schiff Center for Liver Diseases • Sylvester Comprehensive Cancer Center

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The Teams

The theme of this report is exemplified as we follow four complex cases and the many physicians, nurses, laboratory, technical and administrative staff that team up to produce the best possible outcomes for patients. These teams were designed with interdisciplinary thinking and collaborative decision making in mind, and they help thousands of people every year.

Team Cancer Care

Team Heart Attack

Seventy-five physicians and researchers make up the Department of Medicine’s Hematology and Medical Oncology divisions, which are dedicated to the treatment and cure of blood diseases and solid tumors. They work within Sylvester Comprehensive Cancer Center, the region’s only NCI designated cancer center and and translational research and holistic cancer treatment. Department physicians lead Site Disease Groups specializing in Bone & Soft Tissue Cancers, Gastroenterological Cancer, Leukemia, Lymphoma & Myeloma, Thoracic Cancers and Phase One Trials.

UHealth’s helicopter cardiac rescue program came from a need to help patients suffering from acute cardiac symptoms in the Florida Keys. A partnership between University of Miami Hospital, the Division of Cardiovascular Health, the Gordon Center for Research in Medical Education and Monroe Country emergency medical services ensures that no matter how far away they are from the hospital, patients in cardiac arrest can be in a specialized treatment center as quickly as possible.

Team Transplant

Team Diabetes Launched with the opening of the Lennar Foundation Medical Center on the University of Miami’s Coral Gables campus, the Comprehensive Diabetes Center is an ambitious new approach to diabetes care. The CDC recognizes the complexities of managing this prevalent chronic disease by bringing together the best of UHealth: Department of Medicine internists, Bascom Palmer Eye Institute ophthalmologists, podiatrists, dieticians and nutrition educators. Patients have the convenience of seeing all their health care providers in one visit, and the unequaled outcomes that stem from a comprehensive approach. 4

The MTI, an affiliation between Jackson Health System and UHealth, is one of the largest organ transplant programs in the United States, performing heart, lung, intestinal and multivisceral, liver, kidney and pancreas transplants, as well as multiorgan transplants and ventricular assist device (VAD) and extracorporeal membrane oxygenation (ECMO) procedures. In 2018, MTI performed 681 transplants, placing it second in the nation in total transplants. It also holds the distinction of having performed the most kidney transplants since the beginning of Organ Procurement and Transplantation Network recordkeeping, with 430 procedures performed since the beginning of the program.

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Learner Demographics 30%

DATA SUMMARY FY19 Resident Education

26%

MEDICINE EDUCATION PROGRAMS AND DIRECTORS

Number

Medical School in Florida.................................. 39

45%

RESIDENCIES:

Medical School in U.S. outside of Florida........... 68 Medical School Outside the U.S.*...................... 45 *Includes the William J. Harrington Medical Training Program for Latin America and the Caribbean.

Resident Ethnicity...................................... Number Hispanic or Latino ............................................. 53

INTERNAL MEDICINE PRELIMINARY AND CATEGORICAL

14%

35%

Stefanie Brown, MD

16%

MEDICINE-PEDIATRICS Antonia Eyssallenne, MD

27%

White ................................................................ 41 Asian................................................................. 24

FELLOWSHIPS NUMBER

Black or African American................................. 21 49%

Other ................................................................ 12 Resident Gender

Number

Female............................................................... 77 Male.................................................................. 74 Fellow Ethnicity

51%

Number

Hispanic or Latino ............................................. 54

Carlos Alfonso, MD 7%

CARDIOVASCULAR – ADVANCED HEART FAILURE/TRANSPLANT .......................................... 1

20%

Sandra Chaparro, M.D.

42%

CARDIOVASCULAR – ELECTROPHYSIOLOGY ........ 1

White ................................................................ 32 Asian................................................................. 26

Raul Mitrani, MD

25%

Black or African American................................... 9 Other .................................................................. 8 Fellow Gender

CARDIOVASCULAR............................................... 21

CARDIOVASCULAR – INTERVENTIONAL ............... 3 57%

43%

Number

Alexandre Ferreira, MD CARDIOVASCULAR – INTERVENTIONAL ............... 1

Female............................................................... 56

STRUCTURAL HD FELLOW

Male.................................................................. 73

Eduardo de Marchena, MD ENDOCRINOLOGY ................................................. 7

Below: Chief Medical Residents and where they are now: Front row (left to right): Marcelo Fernandes, MD, MPH, Cardiology Fellow, Emory University; Vanessa Blumer, MD, Cardiology Fellow, Duke University. Back row (left to right): Manuel Rivera-Maza, MD, Cardiology Fellow, Washington University in St. Louis; Reginald Pereira, Jr., MD, Pulmonary and Critical Care Medicine Fellow, Mount Sinai Icahn School of Medicine;

Atil Kargi, MD GASTROENTEROLOGY ........................................ 15 David Kerman, MD

Salih Grevious, MD, Cardiology Fellow, Boston University; Chadwick Flowers, MD, Assistant Professor, Division of Hospital

GERIATRICS ........................................................... 8

Medicine, University of Miami; Sabrina Taldone, MD, MBA, Assistant Professor, General Internal Medicine, University of

Jorge Ruiz, MD

Miami. Not pictured: Stephanie Clauss, DO, Assistant Professor, General Internal Medicine, University of Miami

HEMATOLOGY/ONCOLOGY ................................. 16 Judith De Leo Hurley, MD HEPATOLOGY ........................................................ 2 Cynthia Levy, MD HOSPICE AND PALLIATIVE CARE .......................... 4 Khin Zaw, MD INFECTIOUS DISEASES ........................................ 10 Paola Natalia Lichtenberger, MD INFECTIOUS DISEASE TRANSPLANT ..................... 2 Michele Morris, MD NEPHROLOGY .................................................... 10 Oliver Lenz, MD PULMONARY/CRITICAL CARE/SLEEP ................... 24 David De La Zerda, MD / Andrew Quartin, MD / Alexandre Abreu, MD RHEUMATOLOGY .................................................. 4 Carlos Lozada, MD

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Team Cancer Care THE PATIENT Pazit Grosky loves life. Battling a rare form of breast cancer since 2012, she meets the ups and downs of her treatment with a unique style. “I’ve drawn the short straw here, with this cancer,” said Pazit, 54. “But I’m not going to go home and cry about it.” During a particularly low point in Pazit’s treatment, Medical Oncologist Dr. Carmen Calfa asked Pazit to rate her quality of life on a scale from 1 to 10. She said, “I don’t know, a 12? I’ve got great kids, the best husband in the world, my family loves me, I have the most beautiful puppies that take care of me and –within certain parameters—I still get to do everything I want to do.”

THE TEAM Carmen Calfa, MD Breast Medical Oncologist, Assistant Professor, Division of Medical Oncology

Debora Geary, RN, BSN, OCN Research Nurse, Clinical Research Services

Ilia Gonzalez, PharmD Pharmacy Manager, Sylvester Comprehensive Cancer Center

THE DIAGNOSIS After her mother’s brief breast cancer treatment, Pazit performed regular self-exams and other check-ups. She wasn’t worried after noticing a new lump, since she’d had cysts and benign lumps before. Pazit and husband Scott were on their first kid-free trip in 21 years when she noticed severe bruising on her breast and felt that something was wrong. “I said, ‘Let’s enjoy our time away from reality.’ I knew it might be our last vacation for a long time.” During a harrowing ultrasound appointment after their return, a radiologist told Pazit she likely had inflammatory breast carcinoma (IBC), with a nearly 8 cm tumor and cancer that had spread to her lymph nodes.

Pink Sisters Shortly after her diagnosis, Pazit and five other women started an online resource and support group that has grown into a worldwide community of nearly 650 breast cancer patients.

Archie and Kona Dog Caretakers

Below: Pazit (left) and fellow breast cancer patients and Dr. Carmen Calfa at the Miami Dolphins football stadium.

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“This was nearly Stage 4 cancer, and it had an extremely high chance of recurring,” said Dr. Calfa. IBC is one of the rarest and most aggressive breast cancers, accounting for only 0.5% of all patients with breast cancer.

THE TREATMENT Pazit and the Pink Sisters, an online community she and five other women started for breast cancer patients, keep running tallies of their treatments. Since 2012, she’s logged six diagnoses, four biopsies, numerous rounds of chemotherapy, over 37 weeks of radiation, three tries at hormone blockers to reduce her chance of recurrence, two desensitization treatments in order to take hormone blockers and 15 surgeries. She’s also taken dozens of trips with family and friends, visited six countries, seen children Grant and Haley become adults and start their careers, celebrated her 50th birthday and her 30th wedding anniversary, helped lots of families find homes as a Realtor, remodeled three homes from top to bottom, jumped on one impromptu road trip through England and France, brought the family dog count to two after adding a new puppy and gained almost 650 Pink Sisters from all over the world. Pazit has added two clinical trials to her resume since she followed Dr. Calfa to the University of Miami and Sylvester Comprehensive Cancer Center in 2016. Research Nurse Debbie Geary has also worked with Pazit since her time at a prior institution, and was there for her entry into the world of medical research. “We have 15-20 trials open at any time, and we are always trying to offer an innovative clinical trial as an alternative to standard of care for every patient, every time a change in treatment is needed,” said Debbie. This was the case for Pazit, so finding a novel option became the priority for her care. “For patients like Pazit with metastatic disease, we want to look for trials sooner rather than later. Their options might be limited by prior treatment lines they have received, so having patients involved as early as possible helps ensure that they have the opportunity to participate in potentially life-saving research,“ said Dr Calfa.

THE OUTCOME A year into her second trial, Pazit shared some good news with the Pink Sisters. “Today I can finally say I received a clear PET-CT. And with that I can say there is hope! I honestly did not think I would ever hear those words again.” Pazit’s current experimental treatment is a combination of a chemotherapy drug and a drug that blocks the Human D epartmen t o f Medic in e C h air man ’s R e po r t 2019

The Grosky Family: Scott, Pazit, Haley and Grant

Epidermal Growth Factor Receptor 2 (HER2) pathway. Drugs that specifically target certain genes and pathways tend to have fewer side effects. Not dealing with nausea, hair loss or the other unpleasant side effects of chemotherapy means a more normal life for patients. Pharmacy Manager Ilia I. Gonzalez and her team prepare treatments for patients like Pazit, ensuring compliance with trial protocols and monitoring her reaction to the drug. “Every time Pazit comes in for an infusion of her trial drug, we assess how she is doing both in terms of the effectiveness of the drug in fighting her cancer and her experience of adverse effects,” said Ilia. “For trial drugs, when a patient reports a reaction we start our own research to find medications that mitigate the side effect. We work with Dr. Calfa and collaborate with other sites using the trial drug to see if they have had a patient with the same experience. We also report side effects and how we mitigate them to trial sponsors, which informs the study and potentially helps other patients on the trial that might have the same experience.” “Pazit is living with cancer with a good quality of life,” said Dr. Calfa. “If a clinical trial drug stops working, we will move on to another option. It’s a matter of finding a treatment that keeps working, with less toxicity and more precision, until the next drug gets approved. We have to stay focused and continue working together towards finding a cure. That’s the beauty of being involved in research and having clinical trials at your fingertips.” The opportunity to be on a clinical trial is something Pazit knows that other patients do not always experience. Through her involvement in Pink Sisters, she’s met other women who have trouble finding treatments, navigating the health care and insurance systems and even getting regular necessary scans. “The medicine is great, but you also need a strong team, and a strong leader of that team,” said Pazit. “They are my army. They do all the work. My job is to stay alive, and I’m going to keep living as long as my heart keeps beating.” 7

Team Diabetes THE PATIENT Ramon Garganta rocks. The 69-year old spent his career producing and playing music with the likes of Santana, Juanes, Ozzy Osbourne and many others. “I’ve lived in South Florida since 1960 and worked in music since my 20s.” Ramon had been living with Type II Diabetes for years when a stroke made him realize he needed a better treatment plan. “My blood sugar was all over the place. A lifelong friend who is a doctor told me he would help me find better care, and that’s how I came to UM. Before coming to UM, I thought I was going to die,” he said. A visit to the Comprehensive Diabetes Center at the Lennar Foundation Medical Center revealed that Ramon’s condition had indeed worsened and it was compromising his other organs.

THE TEAM

Rajesh Garg, MD Endocrinologist, Director of Clinical Diabetes

Gabriel Contreras, MD Nephrologist

Sonia Yoo, MD Ophthalmologist

Jason Levine, DPM Podiatrist

THE DIAGNOSIS Diabetes Educator Lisa Cardenas-Smith said that all of Ramon’s problems are typically associated with uncontrolled diabetes. “Besides diabetes, hypertension and high cholesterol contribute to macro-vascular complications of the disease, such as stroke.”

Eduardo De Marchena, MD Cardiologist

Lisania Cardenas-Smith, RDN, LD, CDE Diabetes Educator

Below: Ramon Garganta is back to doing what he loves, playing music and spending time with family.

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“The close proximity of multiple specialties fosters a situation in which patients with conditions requiring immediate attention can be seen the same day.” —Dr. Levine Even more concerning, physicians detected the onset of kidney failure and nerve damage in Ramon’s legs. Dr. Rajesh Garg, Ramon’s endocrinologist and the Director of the Comprehensive Diabetes Center (CDC) at the Department of Medicine, explained: “His kidney function was rapidly deteriorating and he would have been on dialysis without proper care. He also had neuropathy increasing the risk of foot ulcers and amputation.” Podiatrist Dr. Jason Levine said the nerve damage in Ramon’s feet and legs could be especially dangerous. “These complications can ultimately result in a hospitalization, amputation, or even loss of life.” A prior lack of communication among his providers likely led to some of Ramon’s issues. “Some medications were ineffective, but he continued taking them due to a lack of coordination. One of these may have added to the kidney failure,” said Dr. Garg.

THE TREATMENT With these challenges identified, Dr. Garg and the CDC team knew a coordinated approach was the key. “Within two weeks of his first visit with me, Ramon had seen a nephrologist (Dr. Contreras), cardiologist (Dr. De Marchena) and a podiatrist (Dr. Levine), and received extensive education about diet and self-management of diabetes.” Dr. Levine said early intervention was key to preventing further nerve damage in Ramon’s legs and feet. “The close proximity of multiple specialties fosters a situation in which patients with conditions requiring immediate attention can be seen the same day,” he said. “We discussed a plan for care focused on prevention of complications related to the diabetic foot. Preventive care and patient education is paramount in preventing these complications.” Since all his providers were located at the Lennar Foundation Medical Center, visits were convenient for Ramon and allowed for a seamless coordination of care. Dr. Garg said, “We discussed the pros and cons of different treatment modalities. The whole discussion centered around improving his quality of life while making the treatment maximally effective.” D epartmen t o f Medic in e C h air man ’s R e po r t 2019

Endocrinologist Dr. Rajesh Garg and Diabetes Educator Lis Cardenas-Smith working together at the Comprehensive Diabetes Center.

Afterwards, Bascom Palmer Eye Institute Ophthalmologist Dr. Sonia Yoo treated Ramon for a cataract on his right eye. “Diabetics often get cataracts at a younger age than non-diabetics, and it was helpful to have notes from Dr. Garg and the rest of the team to understand his diabetic control.”

THE OUTCOME A little over a year since the beginning of treatment at the CDC, Ramon says he is doing well. “It’s a whole new way of looking at things for the future.” It’s a literal new outlook in the case of Ramon’s eyes. Dr. Yoo performed cataract surgery, and he now has much improved vision and less dependence on glasses, with no sign of diabetic retinopathy. Dr. Levine worked with Ramon to find appropriate orthotics and diabetic shoes to reduce the risk of further complications in his feet, and overall the team reduced Ramon’s total medications by half. The most significant change came with the introduction of a new option for diabetes management. Ramon hadn’t previously used insulin, but Ms. Cardenas-Smith said it was clear that medications were not adequately controlling his sugars and were also causing side effects. She remembered Ramon’s first experience with an insulin-injecting pen. “He was initially unwilling, but felt at ease when it was demonstrated to him. This made it possible to start insulin treatment from day one. Through teamwork we showed him that he could be helped, and changed his pessimism to optimism.” Dr. Garg agrees that Ramon’s future is promising. “Ramon’s diabetes, blood pressure and cholesterol are perfectly controlled and his kidney function has been stable for a year. He is back to living a full life.”

Team Heart Attack THE PATIENT Ricky’s story was first reported by UM News and local television station WSVN 7, on January 7, 2019. It was the day after New Year’s Day and Richard “Ricky” Bryan had been enjoying a week-long camping and fishing trip with three of his closest friends. After some early-morning fishing, the group had returned to their Stock Island campsite. The last thing Ricky remembers was taking a shower and brushing his teeth. “I also remember hearing a helicopter,” said Ricky, 47, of Perryville, Maryland. The helicopter he heard was a Monroe County air ambulance. Ricky, who had just suffered a massive heart attack, was being rushed to the emergency room at UHealth Tower, UHealth’s flagship hospital in Miami.

THE TEAM Carlos Alfonso, MD Interventional Cardiologist, Associate Professor of Clinical Medicine, Division of Cardiology

The Elaine and Sydney Sussman Cardiac Catheterization Laboratory, University of Miami Hospital

Angel “Al” Brotons, EMT-P Director of Training Operations in the Gordon Center’s Division of Prehospital and Emergency Healthcare

THE DIAGNOSIS “Ricky had just come out of the shower, and he was complaining of a toothache,” said Ricky’s longtime friend, Sean Harrison, a former volunteer fire-fighter from Lewes, Delaware. “The next thing I know, he was face down in the grass. I rolled him over and I could tell he was having a heart attack – he wasn’t breathing, and had no pulse.”

Monroe County Emergency Medical Services Sean Harrison, Friend

Five days after suffering a massive heart attack, Ricky Bryan reunites with UHealth interventional cardiologist Carlos Alfonso, M.D. and the first responders from Monroe County who helped save his life, along with his son, Jacob, and his best friend, Sean Harrison. Bryan was discharged from UHealth Tower later that day.

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“When the call comes in, our highly skilled interventional cardiology team mobilizes on a moment’s notice and is ready and waiting to meet the patient at the helipad to provide advanced life-saving care,” —Stephanie Moss Harrison yelled to another friend to call 911 while he and a worker from the campground started doing chest compressions in a desperate attempt to save his best friend’s life. Monroe County EMS technicians – trained by the Gordon Center for Research in Medical Education at the University of Miami Miller School of Medicine – arrived within minutes and successfully restarted Ricky’s heart before transporting him to a hospital in nearby Key West. Recognizing that Ricky would need advanced life-saving treatment, they dialed UHealth’s dedicated line for cardiac arrest patients in the Keys and called in an air ambulance to fly him to Miami.

THE TREATMENT The UHealth’s helicopter cardiac rescue program was started out of a need to provide prompt, highly specialized care to patients in the Keys suffering from cardiac arrest or exhibiting symptoms of cardiac distress. “When the call comes in, our highly skilled interventional cardiology team mobilizes on a moment’s notice and is ready and waiting to meet the patient at the helipad to provide advanced lifesaving care,” said Stephanie Moss, D.N.P., APRN, ANP-BC, executive director of clinical operations for cardiovascular services at UHealth. Once aboard the Monroe County rescue helicopter, Ricky wasn’t out of danger yet, however. Shortly after lifting off from Key West, his heart stopped once again. The flight nurse was able to revive him en route to Miami and 50 minutes later they touched down at UHealth Tower, where Dr. Alfonso and his team were waiting. Ricky was alive but in critical condition. He was raced from the helipad to the emergency room and, after being stabilized, he was moved to the Cardiac Catheterization Lab, where Dr. Alfonso went to work. “When he arrived, Mr. Ricky’s right coronary artery was completely blocked, and his heart function was at about 10 to 15 percent,” said Dr. Alfonso, “We unclogged his artery with a small balloon and implanted a stent to prop it open.” D epartmen t o f Medic in e C h air man ’s R e po r t 2019

Ricky Bryan (seated, center) with Gordon Center Director of Training Operations Al Brotons, Cardiac Catheterization Lab Director Dr. Mauricio Cohen and members of his family

THE OUTCOME Just five days later, Ricky was sitting with his family in a UHealth Tower conference room, in front of a group of television news crews, thanking his best friend as well as the UHealth cardiologists and the Monroe County first responders for saving his life. “It takes a system of care, starting with the 911 call and CPR in the field, to help a patient survive sudden cardiac arrest,” Dr. Cohen said. “Everyone in this room played an equally important role in Mr. Bryan’s survival.” It was an emotional moment for everyone as Ricky exchanged hugs with all those who helped save his life on that fateful day. “I feel so blessed,” Ricky said. “I thank all of you, from the bottom of my heart.” “Actually, from the right side of your heart,” quipped Angel “Al” Brotons, director of training operations in the Gordon Center’s Division of Prehospital and Emergency Healthcare, who helped train the first responders who saved Ricky’s life. Had the EMS crew not been trained by the Gordon Center, they may not have been able to restart Ricky’s heart. And had UHealth not established a helicopter cardiac rescue program with Monroe County, Ricky likely wouldn’t have survived the three-hour-plus ambulance ride from Key West. “Coronary disease is the number one cause of sudden cardiac death in the middle-aged population, and outof-hospital cardiac arrest still remains a major cause of death,” Dr. Alfonso said. “But thanks to the care he received at every step along the way – from his friend and first responders to the flight crew and the team here at UHealth – Mr. Bryan is alive today and his prognosis is excellent.” 11

Team Transplant THE PATIENT Antonio Miguel Fontanella inspires. At just 20 years old, he and his family have already lived the lowest lows and highest highs any patient can experience. “Before you can understand my story, you need to know a little bit about my parents.” Antonio Rafael and Barbara Fontanella were both medical doctors in Cuba but lost everything when they immigrated to the United States from Pinar del Rio, Cuba in 1995. The couple supported themselves with odd jobs while working to obtain U.S. medical licenses. Their two sons were born in Miami and when the boys were young, Antonio’s father was accepted to an internal medicine residency in Ponce, Puerto Rico. He later found work as a physician at the Lyster Army Health Clinic in Fort Rucker, Alabama. The family still live nearby in Enterprise, Alabama, but have strong ties to Miami including family, friends and the team that would eventually help save the younger Antonio’s life. During all their years working to succeed in the U.S., the family also faced a bigger challenge: young Antonio was diagnosed with nephrotic syndrome at age three, and they

THE TEAM Dr. George W. Burke III, MD Professor of Surgery, University of Miami Miller School of Medicine, Miami Transplant Institute

Dr. Alessia Fornoni, MD, PhD Chief, Katz Family Division of Nephrology and Hypertension, Department of Medicine

Dr. Jayanthi Chandar, MD Chief, Pediatric Transplant Nephrology

Migdalia Jorge Clinical Transplant Coordinator, Jackson Memorial Hospital

Barbara Fontanella Mom, Kidney Donor Below: Antonio Miguel Fontanella today, an MD/PhD candidate at the University of Miami Miller School of Medicine with plans to pursue a career in Nephrology.

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“The success of his transplant is the result of so many research programs and other investigations developed by U.M, of time dedicated by many people to studying, earning their qualifications, investigating. Names we’ll likely never know but who are also important. It’s the success of the whole team. For all of them, we send our gratitude and our prayers.” —Barbara Fontanella (Left to right) Dr. George W. Burke, MD/PhD candidate Antonio Miguel Fonta-

THE TREATMENT

nella and Dr. Alessia Fornoni in 2019, seven years after Drs. Burke and Fornoni

The surgical team initially planned to remove Antonio’s kidneys and transplant one of Barbara’s the same day, but things did not go as planned. “Before the operation even began, my lung collapsed after intubation, and they cancelled the whole thing – thankfully before they took my mother into the operating room.” Two weeks later Dr. Burke and his surgical team performed the bilateral nephrectomies and removed the peritoneal dialysis catheter. The surgery was staged so he could recover from this first, which meant delaying the transplant part of the surgery. Again, the worst aspect for Antonio was living on hemodialysis for nearly two months and being unable to return to school for eighth grade. On February 29, 2012 Dr. Burke performed the surgery, but 24 hours after a successful kidney transplant operation, Antonio started to experience severe recurrence

played a pivotal role in saving Antonio’s life.

started a grueling ten year journey to a kidney transplant at the Miami Transplant Institute (MTI) and a life-saving clinical trial with the Department of Medicine’s Division of Nephrology and Hypertension.

THE DIAGNOSIS For Antonio, kidney disease was just a fact of life, something he had lived with since before he could remember. “When it came to being sick, it never really hit me. I had to be hospitalized from time to time, but I just became used to it. I got tired easily so I never really got into sports, maybe that’s why I did well in school and like video games so much. It wasn’t until seventh and eighth grade that things really began to change.” Antonio’s family was the first team dedicated to helping him treat his disease. “Antonio’s illness united us as a family. We understood that we were a team and we had to be united to support each other, keep our spirits up and be there for each other in every situation.” When he was thirteen years old, Antonio’s kidneys completely stopped working. The nephrotic syndrome had progressed to end stage renal disease. He had to start dialysis, a time he calls one of the worst in his life. Antonio needed a new kidney to save his life. Luckily, his mom Barbara was a match. “I thanked God that I was compatible and able to donate the kidney. I know there are so many mothers out there who want to donate and cannot.”

Right: Mom and Kidney Donor Barbara Fontanella and 13 year old Antonio Miguel Fontanella, just before his transplant surgery in 2012.

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of proteinuria. “I remember thinking about how excited I was to finally be healthy again, so I was horrified when I woke up and this wasn’t the case.” Thus began a 40-day hospital stay that included a painful recovery from surgery. Antonio had to re-learn how to walk while receiving hemodialysis, plasmapheresis and other treatments to try to reverse the relapse of focal segmental glomerulosclerosis (FSGS) that had caused his native kidneys to fail.

THE OUTCOME While Antonio was in the intensive care unit, Dr. Burke came to the family with a novel treatment option. He had been running a clinical trial with Dr. Alessia Fornoni to prevent recurrence of FSGS. “They gave me abatacept, a drug used to treat rheumatoid arthritis and other autoimmune disorders. Before I knew it, I was back on the normal hospital floor.” Soon afterward, he was discharged from the hospital and on his way home. “I still clearly remember the feeling I had when they let me go. I knew I still had a lot of adjusting to do, but driving home that night, I didn’t really care. I was free.” A year after his transplant, Antonio was free of complications and back to being a normal teenager. He worked with his teachers to pass eighth grade and started high school back in Alabama. He still remembers a visit to Miami to see Dr. Burke during that time. “He told me he was proud of me, and to remember how strong I was emotionally because I had survived something that not many other kids do. I had always wanted to be a doctor, but that moment pushed me to pursue nephrology, so that I could share my strength with others.” Barbara thinks about all the individual effort that came together to save Antonio. “The success of his transplant is the result of so many research programs and other investigations developed by U.M, of time dedicated by many people to studying, earning their qualifications, investigating. Names we’ll likely never know but who are also important. It’s the success of the whole team. For all of them, we send our gratitude and our prayers.” The biggest reason Antonio wants to be a nephrologist is because he knows what it’s like to be a patient. “I know how hungry steroids make you, how bloated you get on bad days, how draining it is to be in dialysis, and all sorts of other depressing experiences with kidney disease. Most of all, I know how hopeless it can feel after you’ve lived your whole life the same way and nothing seems to change.” Seven years after the transplant and clinical trial that 14

Antonio Miguel Fontanella and University of Miami President Dr. Julio Frenk, at an event welcoming his undergraduate class to the campus.

helped him, Antonio is now an MD/PhD candidate at the University of Miami. “Dr. Fornoni has graciously given me the opportunity to learn from her and work in her lab.” He even got to work with his own pre-transplant DNA in the lab, an experience he called “cool and surreal.” “Working with Antonio has been an inspiration for all,” said Dr. Fornoni. “We have been struggling for many years to understand why diseases like the one Antonio experienced often recur after transplant. Antonio’s presence in the Peggy and Harold Katz Family Drug Discovery Center has really been a true motivation to find a cure for scientists and trainees. He is so compassionate, humble, hardworking, extremely inquisitive—all qualities of the most excellent physician scientists.” As a physician, Antonio wants to use his own experience to give patients hope. “I need them to know that if I, a little Cuban boy who spent his whole life between home and hospital, can survive and make it to where I am now, then so can they. I want to walk them there every step of the way.”

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Division Highlights CARDIOVASCULAR MEDICINE CLINICAL TEAMS: Achievements for the

year include performing the Division’s first pulmonary thrombectomy case, the establishment of a hypertension clinic with the Division of Hospital Medicine; a trial collaboration with the Division of Endocrinology, Diabetes and Metabolism and the Department of Radiology to test the liraglutide effect in atrial fibrillation; a partnership with oncology to focus on cancer patients suffering from cardio-toxicities to reduce heart failure readmission rates and manage post-oncologic treatment; and the atrial fibrillation risk factor modification program, a multidisciplinary approach run by advanced practice registered nurses. RESEARCH TEAMS: Division faculty partnered

across departments and continued its partnership with Miami Heart Research Institute, this year funding research collaborations with radiology for Dr. Jeffrey Goldberger’s work with 4D flow MRIs, and collaborations with the Interdisciplinary Stem Cell Institute for research led by Drs. Raul Mitrani, Chunming Dong, Lina Shehadeh and Joshua Hare. Drs. Goldberger and Shehadeh also received new R01 funding from the National Institutes of Health.

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LEARNING TEAMS: Dr. Maureen Lowery, Professor

of Clinical Medicine and the Clerkship Director for the UM Miller School of Medicine, organized new clinical rotations for medical students on the cardiology service including rounding with attendings, fellows and residents. Drs. Michael Dyal and Lina Shehadeh, as course directors for the MD/MPH program, designed an eight-week cardiology module with a wellreceived online learning platform. The team is now working on combining MD and MD/MPH courses to allow for more time spent on critical/ clinical thinking small group sessions, with plans to implement more models to create a hybrid approach to teaching the cardiovascular system. ADMINISTRATIVE TEAMS: Division administration

successfully inaugurated the Pioneers in Cardiology lecture series, which brought Drs. Melvin M. Scheinman and James S. Forrester to campus this academic year. The team also collaborated with Radiology, Patient Access, the Central Business Office, Master Scheduling and many other departments to provide $25 cardiac calcium scoring tests during Heart Month in February. Over 600 patients took advantage of the opportunity, allowing them to connect with cardiologists and other specialties.

Cardiovascular Medicine Chief Dr. Jeffrey Goldberger demonstrates a 4D MRI.

OTHER HIGHLIGHTS: Dr. Mauricio Cohen was

development and to continue into the next inducted into the International Andreas academic year. In addition to augmenting Gruentzig Society (IAGS), served on the writing clinical work and teaching of our residents committee of the ACC/AHA revascularization and students, this collaboration is anticipated guidelines and as chair of the Critical Care to strengthen the research/publication track Committee of American Heart Association. Dr. record of both Hospital Medicine and Clinical Maureen Lowery was recognized for promoting Pharmacology and to develop clinical research a positive learning environment in the PULSE platforms within the rich clinical environment 360 survey. Dr. Lina Shehadeh served as a of UHealth Tower. The scope of the research member of the National Heart, Lung, and Blood is expected to span the continuum from the Institututeâ&#x20AC;&#x2122;s R01 study section for Myocardial Clinical Pharmacology Research Unit to the Ischemia and Metabolism. The Division Hospitalist at the bedside. hosted its annual Miami Valves Symposium in EXTERNAL AND INTERNAL CLINICAL RESEARCH TEAMS: conjunction with the International Medicine The drug development pipeline is replete Institute, led by Dr. Eduardo De Marchena. with over 14,000 new compounds undergoing

CLINICAL PHARMACOLOGY CLINICAL, TEACHING, AND RESEARCH COLLABORATIONS: The operations of the Divisions

Beloved veteran cardiologist Dr. Eugene J. Sayfie (center) with learners and researchers at the 5th Annual Department of Medicine Research Day named in his honor.

of Clinical Pharmacology and Hospital Medicine are vital to identifying opportunities for team medicine, team education, team research and facilitating collaboration across divisions. In 2018-2019, the divisions began strategic discussions and planning for the implementation of a standing collaboration encompassing clinical work, clinical teaching, and clinical research. The strategic collaborations are now in the implementation phase and are planned to undergo further

preclinical and clinical development. Many of these novel compounds will require clinical testing in special populations such as patients with kidney and liver disease. Clinical Pharmacology conducts approximately 15 Phase I studies per year in special populations and has developed several strategic alliances with pharma and within the Miller School and the Department of Medicine to conduct these studies in a streamlined and timeefficient platform. The new platforms are consistent with the timelines dictated by modern drug development. The Division of Clinical Pharmacology can also help with protocol development, tailoring patient entry criteria to specific compounds and provide

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from Miami Transplant Institute. This allows patients with liver disease to be admitted under the care of faculty who can more efficiently direct their care.

Left: Laboratory Director Vanessa Caizapanta prepares patient blood samples in the Clinical Pharmacology Research Unit.

RESEARCH TEAMS: Drs. Oriana Damas and

Patricia Jones were selected as Scholars for the American Gastroenterology Associationâ&#x20AC;&#x2122;s (AGA) FORWARD Program, which allows participants to develop their leadership skills, strengthen their research and management skills with training from top investigators and network with underrepresented minority leaders who are shaping the future of academic medicine. Dr. Maria Abreu was selected as a Mentor for the AGA FORWARD Program. LEARNING TEAMS: The division started two

advice on protocol implementation. In addition, adding a special arm for patient studies to an existing drug development program could offer important information to inform the planning and implementation of larger Phase III trials.

DIGESTIVE HEALTH AND LIVER DISEASES

important and successful educational initiatives in the past year: the gastroenterology (GI) section added a third year medical student elective to the inpatient GI service at UHealth Towers, and also offered residents the opportunity to rotate in GI and Hepatology outpatient clinics. Additionally, the creation of a house staff-run inpatient transplant service at JMH now enhances learning opportunities in transplant hepatology for residents as well as fellows. In the past year, GI fellows participated as educators in the small-group case-based education for

Below: Hepatologist Dr. Patricia Jones, recipient of a 2019 Schally Research Award, and Dr. Roy Weiss, Chairman of the Department of Medicine.

CLINICAL TEAMS: Dr. Michelle Pearlman

developed a multidisciplinary collaboration with the Division of Laparoendoscopic and Bariatric Surgery to develop a comprehensive weight loss clinic to identify, educate, and manage patients who are overweight and obese. She has a close partnership with bariatric surgery and aids in the management of postbariatric malnutrition, weight regain, surgical evaluation and aftercare. Dr. Pearlman has also added a half day clinic dedicated to Sylvester Comprehensive Cancer Center patients who are on active cancer treatment or post treatment with malnutrition problems. The Division established a new inpatient service at Jackson Memorial Hospital (JMH) staffed by hepatology section faculty and fellows in collaboration with advanced registered nurse practitioners D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2019

second-year medical students and the GI and Transplant Hepatology fellowship programs reorganized and combined their educational conferences. ADMINISTRATIVE/STRATEGIC TEAMS: Team IBD

(Inflammatory Bowel Disease), led by Dr. Maria Abreu hosted several educational opportunities for registered nurses, advanced practice providers, fellows and residents, and international physicians. A one-day “Impact IBD” symposium was held on the Coral Gables Campus early in the year, and over 100 attended the “Impact IBD” conference. In May 2019, Team IBD hosted ten international gastroenterologists and colorectal surgeons from Brazil for an IBD 360 preceptorship, with two more planned for FY2020. In March 2019, the gastroenterology section hosted the 2nd Annual GI Congress, a two-day conference on Miami Beach. This was well attended by physicians and advanced practice providers nationally and internationally.

These educational initiatives provide local and international exposure for Gastroenterology at UHealth. The Pancreas Center is dedicated to the diagnosis and management of pancreatic diseases, and is also home to a unique team, father and son Drs. Jamie Barkin and Jodie Barkin (pictured below). OTHER HIGHLIGHTS: Drs. Amar Deshpande and

Cynthia Levy were promoted to Professor of Medicine, effective June 1, 2019. Dr. Cynthia Levy was installed as the Arthur H. Hertz Endowed Chair in Liver Diseases. Dr. Marcelo Larsen was awarded Fellow status in the American College of Gastroenterology. During end of the academic year ceremonies, Dr. Daniel Sussman received the 2019 George H. Paff Teaching Award, Dr. Patricia Jones received the 2019 Schally Research Award and Dr. Amar Deshpande received the 2019 Distinguished Educator Award.

Drs. Jodie Barkin (left) and Jamie Barkin (right) are a fatherson team dedicated to helping patients with pancreatic disease. The Drs. Barkin team up to help patients and advance research into new treatments and cures for pancreatic disease at the Digestive Health and Liver Diseases Division’s Pancreas Center.

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ENDOCRINOLOGY, DIABETES & METABOLISM CLINICAL TEAMS: Through the Comprehensive

Diabetes Center (CDC) and service lines dedicated to thyroid cancer, pituitary and neuroendocrine diseases, the Division brings a multidisciplinary approach to care for all patients. This year, the CDC incorporated psychological health as a standard of care for all patients, in addition to diabetes education, nutrition counseling and podiatry services. Under the leadership of Dr. Gianluca Iacobellis, the Division also piloted a weight loss clinic for obese pre-diabetic and type two diabetes patients, and designed a soon to be launched mobile phone application with the Department of Computer Sciences to improve the diabetes patient experience and facilitate communication with physicians. RESEARCH TEAMS: Essential to the Division’s

research mission are innovative collaborations with other departments. Research Professor Dr. Alejandro Caicedo and the Department of Neurology’s Dr. Carlos Moraes develop novel methods to study the behavior of mitochondria in insulin-producing cells using the anterior chamber of the eye as a window for imaging. Through the Division’s bone program, Dr. Rodrigo Valderrabano works with the Miami D epartmen t o f Medic in e C h air man ’s R e po r t 2019

Project to Cure Paralysis as well as the Department of Kinesiology and the Division of Cardiology to study using statins to control endocrine disease risk, metabolism in persons with spinal cord injuries, bone density in extreme exercisers and sedentary subjects and how hemoglobin affects the risk of hip fracture in older men and women.

Endocrinology Chief Dr. Ernesto Bernal-Mizrachi (left), Endo Fellowship Program Director Dr. Atil Kargi (second to left) and Dr. Violet Lagari-Libhaber (right) with Endocrinology Fellows.

LEARNING TEAMS: In addition to year-long

discussions among the faculty to review feedback from endocrinology fellows and evaluate the fellowship training program, in 2018-2019 the division underwent a self-study in preparation for an anticipated site visit by the Accreditation Council for Graduate Medical Education. A task force including faculty, current trainees and past graduates convened to review five years of survey data from fellows and faculty as well as board scores and surveys of program graduates. The effort has resulted in a more thorough understanding for faculty and the Division has already implemented several improvements to program curriculum and administrative procedures. ADMINISTRATIVE/STRATEGIC TEAMS: During the

past year the Division focused on recruiting two new clinical faculty, allowing for an expansion of service at UHealth’s Kendall location. Administrators also prioritized investments 19

and pulmonary evaluation, and consultations with a nutritionist and an exercise physiologist. Concierge medicine members pay an annual fee for an expansive physical exam as well as 24/7 phone and email support from physicians with patient populations about 1/5 the size of a typical practice. Patients range from highstress business professionals to teachers, firefighters and others with demanding work schedules, as well as international patients who seek the convenience of completing exams and testing in a single day. OUTREACH TEAMS: Associate Professor Sonjia

General Internal Medicine’s Dr. Laurence Gardner, a Professor of Clinical Medicine, prior Chair of Medicine and former Acting Dean of the Miller School of Medicine, received the 2019 Barkin/Rogers Distinguished Mentor Award.

Kenya’s “clinic without walls” received a huge boost in the form of a new three-year, $1 million grant from the Florida Department in junior research faculty and contributions to their professional development, which led to an of Health (DOH). Community-Based HIV Awareness for Minority Populations (CHAMP) excellent year for grant funding. employs community-based health workers to OTHER HIGHLIGHTS: Research Assistant Professor administer rapid HIV tests at clinics, on the Joana Almaca, PhD won the Faculty Council street and even at house parties in Miami’s Research Award to support her work in the Overtown, Liberty City and Little Haiti role of pericytes in pancreatic islet fibrosis neighborhoods. The program has doubled its in type two diabetes patients. Dr. Alejandro staff and now has access to the DOH’s testAyala received the Department of Medicine’s and-treat programs, where those who test Distinguished Clinician Award. Research positive can receive a 30-day supply of Assistant Professor Rene Barro, PhD, won the medication the very same day. Dr. Kenya Stanley J. Glaser Foundation Research Award. hopes this model becomes the standard for Division Chief Dr. Ernesto Bernal-Mizrachi communities where HIV infections are still won an NIH R01 grant for his studies in rising and still the leading cause of death pancreatic beta cells as well as a MERIT Award among young, black adults. from the Veterans Administration to study RESEARCH TEAMS: As the lead site of the the role of glucagon in diabetes. Dr. Mizrachi Southeast enrollment center for All of Us, was also elected as a member of the American University of Miami spearheads the effort Diabetes Association Pathway Mentor to enroll a diverse population of study Advisory Group. participants from Florida and Georgia to this long-term observational study led by the GENERAL INTERNAL MEDICINE National Institutes of Health. The program CLINICAL TEAMS: Drs. Stephen V. Avallone and collects health records, blood and urine Cristina A. Pravia launched executive health samples, survey results and other information and concierge medicine programs to provide from participants, and will eventually include personalized and expedited care for members, whole genome sequencing. It aims to enroll an effort based on their prior work launching 1 million participants in order to build large similar programs at Cleveland Clinic. Executive databases that will inform future research and health patients can schedule a variety of exams improve health outcomes on a national level. and testing for one day, including a thorough physical, blood work, cardiovascular screening

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Scientists at work in the laboratory of Dr. Stephen Nimer, Professor in the Division of Hematology and Director of the Sylvester Comprehensive Cancer Center.

LEARNING TEAMS: Thirty faculty, staff and

learners took part in the University’s inaugural humanitarian disaster response course, which simulates the intense conditions healthcare providers experience in these circumstances. Participants in the three-day program operated by Humanitarian U learned how to work in intense conditions with limited rest, meals, electricity, plumbing and other resources. They were given limited information about the circumstances they would encounter, beyond the knowledge that they would be sleeping outside and foregoing showers. Upon arrival, they were immersed in life helping victims of an earthquake and tsunami in an area experiencing civil war and poverty, and learned to deal with these conditions while providing care for patients. As Miami’s location make it an ideal hub for disaster response, division faculty hope to offer University’s own version of the training program every year for nursing, medical and public health students.

GERIATRICS & PALLIATIVE MEDICINE CLINICAL TEAMS: The Division expanded its

inpatient consult service to include two Advanced Practice Registered Nurses and a dedicated social worker. Additionally, the Division maintains its current outpatient clinics at the Sylvester Comprehensive Cancer Center, as well as the Deerfield Beach, Lennar Foundation Medical Center, and Kendall satellite locations. LEARNING TEAMS: The Geriatric and Palliative

Medicine training program for medical students continues to be well-respected at the national level and course faculty were invited to present curricular materials at the Annual D epartmen t o f Medic in e C h air man ’s R e po r t 2019

Scientific Meeting of the American Geriatrics Society. The Geriatrics and Palliative Medicine Clerkship has been restructured as a 2-week course, and as part of the overall curricular reform taking place. Geriatrics content is slowly being integrated earlier in the medical school curriculum in both the MD and MD/ MPH programs. The Accreditation Council for Graduate Medical Education approved the creation of a combined fellowship in Geriatrics and Palliative Medicine as well as the Pediatrics and Palliative Medicine Fellowship track implemented last year. ADMINISTRATIVE/STRATEGIC TEAMS: The Division

of Geriatrics was selected as the next host of the Inter-Professional Education eXchange (IPEX) 2019-2020. This program will develop, implement and evaluate inter-professional education in palliative oncology care. OTHER HIGHLIGHTS: Dr. Soares and Dr. Sanchez

have been invited as guest members of the Alliance of Dedicated Cancer Centers (ADCC) peer support-group in palliative medicine at cancer centers. The goal is to share challenges and strategies on integrating palliative medicine in our individual cancer centers.

HEMATOLOGY CLINICAL TEAMS: The Lymphoma Program,

directed by Dr. Izidore Lossos and joined last year by Hodgkin’s disease expert Dr. Craig Moskowitz, expanded its program activities, which include a unique program in virally related lymphomas led by Dr. Juan Carlos Ramos. Working with the division’s Stem Cell Transplant and Cellular Therapy team, the program pioneered the use of cellular therapies to address a variety of lymphomas. The team 21

also gathers hematopathologists, radiation oncologists and radiologists to review difficult cases during a weekly Lymphoma Tumor Board meeting. The Leukemia program, led by Dr. Justin Watts, sees a large number of patients with leukemias in the clinical setting and have also developed a significant clinical trial portfolio. They lead the institution in accrual of patients to therapeutic trials and their patient population and work with the Stem Cell Transplant team has led to an unprecedented increase in the number of patients undergoing stem cell transplantation.

ADMINISTRATIVE/STRATEGIC TEAMS: Dr. Stephen

RESEARCH TEAMS: Laboratory efforts contribute

OTHER HIGHLIGHTS: Drs. Nimer, Watts and other

significantly to the Division’s activities, with researchers collaborating to study lymphoma pathogenesis, viral lymphomas, new potential therapies for T-cell malignancies and relapsed lymphoma and a novel use of metabolic imaging in lymphoma. Efforts in the lab over the years and collaboration with the Sylvester Comprehensive Cancer Center (SCCC) have a direct impact on patients, as the Leukemia program’s substantial clinical trial portfolio includes five investigator initiated protocols based on novel translational approaches developed at SCCC.

members of the Division successfully competed for a Leukemia/Lymphoma Society Scientific Center of Research grant. In recognition of his stellar efforts in translational and clinical research, Dr. Watts was awarded the PAP Corps Endowed Chair in Leukemia Research.

Nimer, Director of Sylvester Comprehensive Cancer Center, spearheaded institutional efforts that led to SCCC’s designation as a National Cancer Institute Cancer Center. This milestone has been a major catalyst for ongoing expansion and improvement of cancer-related basic, translational and clinical research. A recruitment strategy put in place by the Division has resulted in ongoing recruitment of outstanding candidates for the faculty, which are reviewed collectively at regular recruitment meetings led by Dr. Jonathan Schatz.

HOSPITAL MEDICINE CLINICAL TEAMS: The Division now has a daily

inpatient census at UHealth Tower of 140 -150 patients, making it the largest admitting service at the hospital. Nine teams of faculty members are divided by subspecialty, including LEARNING TEAMS: This year, Dr. Craig Moskowitz teams dedicated to cardiology, hematology, introduced a bi-weekly program for hematology/ oncology, pulmonary and inpatient consults. oncology fellows entitled, “How I Treat,” This year, the implementation of decreased which selects unique topics in hematology and rotations among teams has improved presents summaries of current approaches to communication and allowed for the quick treatment delivered by faculty who are expert implementation of quality control measures. in the area. Members of the highly competitive The Division also expanded its overnight fellowship program, which accepts only six of presence with two nocturnists and two the over 300 applicants each year, also now advanced registered nurse practitioners on have access to a variety of multidisciplinary duty each night. conferences inaugurated in the Division. RESEARCH TEAMS: Dr. Maria Delgado served Division faculty also take part in educational as sub-investigator for a control trial of renal conferences outside the University including denervation in subjects with hypertension OncLive, a multidisciplinary conference and Dr. Jorge Florindez continued his work broadcast on television, the Miami Epigenetic Conference and Brazilian board review courses with SEER (Surveillance, Epidemiology, and End Results) databases, analyzing survival in at the Einstein Medical Center in Sao Paulo, plasmablastic lymphoma and genetic testing in Brazil. gastrointestinal stromal tumors.

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INFECTIOUS DISEASES CLINICAL TEAMS: Dr. Susanne Doblecki-Lewis and

LEARNING TEAMS: Internal medicine residents

have access to Hospital Medicine faculty 24 hours a day, seven days a week. Procedures at Jackson Memorial Hospital continue to be a favorite rotation among the residents, who have requested the addition of a Hospitalist rotation to the program.

Division Chief Mario Stevenson, PhD, received grant funding from the City of Miami Beach and the Florida Department of Health to break down barriers to pre-exposure prophylaxis (PrEP), which is highly effective in reducing HIV infection. Through partnership with the Sylvester Comprehensive Cancer Center’s Gamechanger mobile clinic, an effort led by Population Health and Computational Sciences Professor Erin Kobetz, the team now offers PrEP in combination with cancer screening services in a de-stigmatized and convenient setting at four sites in South Florida.

Left: (Left to right) Infectious Diseases faculty members Drs. Maria Alcaide and Margaret Fischl teamed up with Dr. Deborah Jones Weiss of Psychiatry and Behavioral Sciences to secure $14MM in funding for HIV/AIDS research.

RESEARCH TEAMS: Drs. Maria Alcaide and

Margaret Fischl collaborated with Psychiatry and Behavioral Sciences’ Dr. Deborah Jones Weiss, as well as the Miami Center for AIDS Research, the AIDS Institute and the new

ADMINISTRATIVE/STRATEGIC TEAMS: Faculty are

involved in several quality improvement projects at the hospitals, including focuses on sepsis, utilization management, prevention of deep vein thrombosis and discharge planning. Other highlights: Dr. Efren Manjarrez served as a speaker at the American College of Physicians and the Society of Hospital Medicine (SHM) annual meetings, and authored continuing medical education online modules for SHM. Dr. Aldo Pavon Canseco also spoke at the SHM annual meeting, delivering a talk on Bedside Procedures and Emergent Airway Management for the Hospitalist. Dr. Maria Delgado authored American Heart Association abstracts on isolated systolic hypertension and new guidelines, the Trp allele of the Gly460Trp polymorphism and the urinary sodium potassium ration in hypertensive and normal tensive subjects. Right: Dr. Hansel Tookes, Assistant Professor of Clinical Medicine in the Division of Infectious Diseases, received the 2019 Diversity Award in part for his work in creating and serving as Medical Director of the first needle exchange program in Florida, the Miami IDEA Syringe Services Program, an initiative he spearheaded while a resident at University of Miami/ Jackson Memorial Hospital.

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(Left to right) Infectious Diseases faculty member Dr. Allan Rodriguez, study participant Madison Waldron and Dr. Andrew Wawrzyniak of the Department of Psychiatry and Behavioral Sciences. Drs. Rodriguez and Wawrziniak teamed up to study the extremely high rates of HIV in transgender women through participation in the National Institutes of Health’s LITE Study (Leading Innovation for Transgender Women’s Health and Empowerment).

Center for HIV Research in Mental Health to secure a $14MM grant from the National Institutes of Health to join 12 other sites around the United States in launching the Multicenter AIDS Cohort Study (MACS)/ Women’s Interagency HIV Study (WIHS) Combined Cohort Study. The combined effort will be the largest prospective cohort study in the nation, offering researchers the opportunity to study not only HIV infection, but also heart, lung, blood and sleep comorbidities, mental health and neurological illnesses, diabetes, kidney failure, liver disease and certain cancers. The study is also among the few to allow for high impact science focused on gender differences and health disparities, improve the lives of those living with HIV in the community and provide a unique opportunity for junior and established investigators in every discipline in research to work together. LEARNING TEAMS: The Infectious Diseases

curriculum for learners is based in specialized tracks and mutual collaborations with local, regional and international organizations and universities. Of particular note is the Tropical Medicine program, which offers bidirectional rotations in locations in Colombia, Peru and Brazil, as well as continued communication via teleconference with Peruvian and Spanish participants and the promise of expansion to 24

new regions of Latin America and Europe. In the Transplant Immunosuppressed Infectious Diseases track, learners from both the University and regional hospitals experience consultation rotations in the solid and bone marrow transplant units at Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center, as well as immunosuppressed outpatient clinics, monthly case conferences, journal clubs and transplant meetings. A new track in HIV offered in collaboration with private organizations emphasizes translational research and provides medical students, residents and fellows with rotations in research units, outpatient clinics, mentoring in HIV prevention and training in primary care and management. ADMINISTRATIVE/STRATEGIC TEAMS: As Florida is

the state in the U.S. most impacted by HIV/ AIDS, division faculty have taken important roles in the overall strategy to reach Miller School of Medicine Dean Henri Ford’s vision of a 90% reduction in new infections over the next ten years. In UHealth medical settings, division faculty take on central oversight roles in infection control, antimicrobial stewardship and patient safety, efforts that are critical to the effectiveness of the health systems’ transplant and HIV/AIDS research units.

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MEDICAL ONCOLOGY CLINICAL TEAMS: In collaboration with Sylvester

Comprehensive Cancer Center (SCCC), the Division opened the Oncology Care Clinic at UHealth Tower, a walk-in and same-day referral service where existing patients can see a Hematology/Oncology Nurse Practitioner or Physician Assistant for help with chemotherapy associated side effects and other minor, non-emergent illnesses. The ability to see specially trained practitioners without a prior appointment helps these patients avoid unnecessary emergency room visits and hospital admissions. Ninety-five percent of patients seen so far have been able to return home the same day. RESEARCH TEAMS: Division faculty member Dr.

Carmen Calfa worked with SCCC Precision Medicine to create the only site in Florida offering access to Targeted Agent and Profiling Utilization Registry (TAPUR) data, which helps physicians find treatment options for patients with cancers that are no longer responding to standard treatments. The TAPUR study, sponsored by the American Society of Clinical Oncology, brings the University together with 113 clinical sites all over the nation to create a large database describing the performance of FDA-approved anticancer drugs. After patients undergo genomic or molecular testing, researchers can use TAPUR data to find a potential match to 16 treatment options. To date, 74 patients have been matched to experimental drug regimens.

D epartmen t o f Medic in e C h air man ’s R e po r t 2019

LEARNING TEAMS: 2019 marks the first year of

Above: Division of Medical

the University’s Calabresi Clinical Oncology Research Career Development Program, a training program sponsored by a National Institutes of Health’s K12 award. Working with SCCC and other oncological departments, the division developed goals for three subcommittees dedicated to Diversity and Recruitment, Curriculum and Career Development. Faculty developed the program curriculum, wrote a request for applications, reached out to potential trainees and mentors and recruited three inaugural scholars to the program.

Oncology faculty member Dr. Gilberto Lopes (right) serves as a judge at the poster presentations of this year’s Eugene Sayfie Research Day.

ADMINISTRATIVE/STRATEGIC TEAMS: The

Division’s Annual Oncology Update, held at the Conrad Hotel in Ft. Lauderdale, exceeded the prior year’s attendance and featured a live international feed with over 166 registered participants from 19 countries. The event, now in its third year, gives attendees the opportunity to learn and discuss the latest research and clinical advances presented at the annual meeting of the American Society of Clinical Oncology. The conference welcomed medical and radiation oncologists, physician assistants, nurse practitioners, nurses and trainees engaged in the care of cancer patients.

Below: MedOnc Slingerland Lab: Medical Oncology Professor Dr. Joyce Slingerland (center), Director of the Braman Family Breast Cancer Institute, with her laboratory team. The lab’s current research initiatives include investigating new links between estrogens, inflammation, obesity and breast cancer, a key to understanding why such cancers are more common after menopause.

ADMINISTRATIVE/STRATEGIC TEAMS: Teams for

education, inpatient dialysis, outpatient dialysis, ambulatory care, quality improvement, clinical research and transplant were established to allow faculty and staff to gain more administrative responsibilities and to grant the best outcomes to patients and to trainees. OTHER HIGHLIGHTS: Nephrology faculty had

a presence at international conferences on four different continents, publications in top journals (JAMA, Nature Communication, JCI) and received several local, regional and national awards for education, research and clinical care.

Dr. Alessia Fornoni (left), Chief of the Katz Family Division of Nephrology and Hypertension, received the first ever Faculty Mentor Award at this yearâ&#x20AC;&#x2122;s Eugene J. Sayfie Research Day. It was presented by Dr. Maria Abreu (right), Vice Chair of Research.

KATZ FAMILY DIVISION OF NEPHROLOGY AND HYPERTENSION

PULMONARY, CRITICAL CARE AND SLEEP MEDICINE

CLINICAL TEAMS: A new dedicated Polycystic

CLINICAL TEAMS: The Division took part in

Kidney Disease (PKD) clinic was established to offer new FDA-approved treatment opportunities to patients from the community and to set the basis for an interdisciplinary PKD Center.

the creation of a new UHealth Tower Rapid Response Team. With plans to build up the nurse practitioner and physician assistant (advanced practice practitioner) ranks, the teamâ&#x20AC;&#x2122;s goal is the expansion of intensive care unit consults to provide more efficient and expedited care for decompensating floor patients. The Division also opened the new cardiovascular intensive care unit service line, a collaborative effort between cardiothoracic surgeons and the critical care team to provide 24/7/365 critical care support for these post-op patients.

RESEARCH TEAMS: The recognition of the

Nephrology team as an internationally acclaimed team in the field of lipid biology has promoted innovative NIH-funded research in collaboration with the Department of Radiation Oncology and with the Miami Transplant Institute. Mentorship of K awardee applicants from different disciplines has also been a priority, with three applications submitted. The Division also established a new dedicated clinical research unit with a focus on glomerular diseases and cystic kidney diseases. LEARNING TEAMS: The Division has developed an

educational environment model where clinical responsibility is solely focused on teaching cases and the clinical load is dramatically reduced and replaced by educational core curriculum conferences. They have exercised and expanded the development of learning teams with quality improvement projects that are now benefiting the entire institution.

RESEARCH TEAMS: The Division has set new

internal standards for identifying research studies that are multidisciplinary to encourage collaborative efforts between teams including: sleep medicine and cardiology, pulmonary hypertension and cardiology, cystic fibrosis and mental health and cystic fibrosis and physical therapy. LEARNING TEAMS: The Division held a joint

training session in critical care ultrasound with Emergency Department residents, fostering collaboration among departments and integrating a learning environment and standard practice for ultrasound use in critical care and emergency care areas. It also combined dual respiratory modules into one, U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

giving medical students a course that has performed better historically while eliminating duplication of efforts for faculty and the disruption of clinical workflows. ADMINISTRATIVE/STRATEGIC TEAMS: A registered

nurse training program on sepsis management at UHealth Tower includes a multidisciplinary team of physicians from the division working with Infectious Diseases, Hospital Medicine and Emergency Medicine. The program also has support from Nursing, Pharmacy, Laboratory, Data Analysis and Biostatistics, and has led to a best practice alert for clinical orders in the electronic medical records system. Faculty also collaborated with the University of Miami Ethics group on standards for Do Not Resuscitate (DNR) orders and protocols.

RHEUMATOLOGY AND IMMUNOLOGY CLINICAL TEAMS: Dr. Elana Oberstein worked

with Pulmonologist Marilyn Glassberg to expand the combined Rheumatology-Interstitial Lung Disease Clinic by adding a Scleroderma Lung Disease Clinic. This provides more access and expertise to the treatment of one of the most dangerous complications of scleroderma spectrum disorders, while opening up additional new avenues for research.

second year medical students. The team works to “flip the classroom,” moving to a case-based curriculum where trainees learn about diseases in collaborative teams rather than by listening to lectures. Student evaluations showed high satisfaction with the new approach, and test performance for the group remained stable with their peers. ADMINISTRATIVE/STRATEGIC TEAMS: Rheumatology

Administrator Anouk Gachelin developed a strategic collaboration with the administrative group of the Digestive Health and Liver Diseases Division, led by Carol Cottrell. This allows for cross coverage of administrative staff and sharing resources and expertise common to these fields, such as seeking insurance authorizations for biologic immunotherapies. By working smarter in expert teams, the Divisions provide better, faster, more efficient service to patients and caregivers. OTHER HIGHLIGHTS: The Division welcomes

Dr. Nitya Ramreddy to the faculty. A recent graduate of the Division’s fellowship training program, Dr. Ramreddy won top honors at the 5th Annual Eugene J. Sayfie Research Day in 2019. She has a particular interest in autoimmune diseases induced by cancer immunotherapies.

Rheumatology Medical Grand Rounds Speaker Dr. Joel M. Kremer, Pfaff Family Professor of Medicine and Director of Research at Albany Medical College and the Center for Rheumatology with Dr. Ozlem Pala.

RESEARCH TEAMS: Dr. Maria Carpintero

leveraged collaborations with the Katz Family Division of Nephrology and Hypertension to enhance her lupus research. By reaching high levels of recruitment into her treatment trials with novel lupus drugs, Dr. Carpintero earned an extra $80,000 in research support from the Lupus Clinical Investigators Network (LuCIN), and provided effective therapy for patients with lupus who had not found answers with conventional treatments. These funds boosted Rheumatology’s total Clinical Research funds received to over $700,000 for this past year. LEARNING TEAMS: Division Chief Eric Greidinger

worked closely with Professor Robert Irwin from the Department of Physical Medicine and Rehabilitation as co-directors of the musculoskeletal medicine course for Miami’s D epartmen t o f Medic in e C h air man ’s R e po r t 2019

High Impact Publications In the following section, we share all the articles our faculty published in journals with high impact factors. Impact factors measure the frequency with which these journals are cited by other researchers, and are an indicator of the most prestigious peer-reviewed publications. This list includes all publication in journals with impact factors greater than 4.9.

CARDIOLOGY

CLINICAL PHARMACOLOGY

Amin AP, Pinto D, House JA, Rao SV, Spertus JA, Cohen MG, Pancholy S, Salisbury AC, Mamas MA, Frogge N, Singh J, Lasala J, Masoudi FA, Bradley SM, Wasfy JH, Maddox TM, Kulkarni H. Association of SameDay Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes. JAMA Cardiol. 2018;3(11):1041-9.

Preston RA, Arciniegas R, DeGraff S, Materson BJ, Bernstein J, Afshartous D. Outcomes of minority patients with very severe hypertension (>220/>120 mmHg). J Hypertens. 2019;37(2):415-25.

Damluji AA, Bandeen-Roche K, Berkower C, Boyd CM, Al-Damluji MS, Cohen MG, Forman DE, Chaudhary R, Gerstenblith G, Walston JD, Resar JR, Moscucci M. Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock. J Am Coll Cardiol. 2019;73(15): 1890-900.

Almaca J, Weitz J, RodriguezDiaz R, Pereira E, Caicedo A. The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow. Cell Metab. 2018;27(3):630-44 e4.

Fanaroff AC, Zakroysky P, Wojdyla D, Kaltenbach LA, Sherwood MW, Roe MT, Wang TY, Peterson ED, Gurm HS, Cohen MG, Messenger JC, Rao SV. Relationship Between Operator Volume and Long-Term Outcomes After Percutaneous Coronary Intervention. Circulation. 2019;139(4):458-72. Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, FaiellaTommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC, Jr., Sperling L, Virani SS, Yeboah J. 2018 AHA/ACC/ AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/ NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019;139:e1082â&#x20AC;&#x201C;e1143. Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, FaiellaTommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC, Jr., Sperling L, Virani SS, Yeboah J. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019 Jun 25;73(24):3168-3209. 28

ENDOCRINOLOGY

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jorgensen K, Flodstrom-Tullberg M, Hyoty H, Insel RA, Lernmark A, Lloyd RE, Morgan NG, Pugliese A. Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia. 2019;62(5):744-53. Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jorgensen K, Flodstrom-Tullberg M, Hyoty H, Lloyd RE, Morgan NG, Pugliese A. Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia. 2019 May;62(5):744-753. Foster ED, Bridges ND, Feurer ID, Eggerman TL, Hunsicker LG, Alejandro R, Clinical Islet Transplantation C. Improved Health-Related Quality of Life in a Phase 3 Islet Transplantation Trial in Type 1 Diabetes Complicated by Severe Hypoglycemia. Diabetes Care. 2018;41(5):1001-8.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ, Type 1 Diabetes TrialNet ATGGSG. Low-dose Anti-Thymocyte Globulin Preserves C-Peptide and Reduces A1c in New Onset Type 1 Diabetes: Two Year Clinical Trial Data. Diabetes. 2019 Jun;68(6):1267-1276. Qu C, Kunkalla K, Vaghefi A, Frederiksen JK, Liu Y, Chapman JR, Blonska M, Bernal-Mizrachi L, Alderuccio JP, Lossos IS, Landgraf R, Vega F. Smoothened stabilizes and protects TRAF6 from degradation: A novel non-canonical role of smoothened with implications in lymphoma biology. Cancer Lett. 2018;436:149-58. Rodriguez-Diaz R, Molano RD, Weitz JR, Abdulreda MH, Berman DM, Leibiger B, Leibiger IB, Kenyon NS, Ricordi C, Pileggi A, Caicedo A, Berggren PO. Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point. Cell Metab. 2018;27(3):549-58 e4. Watanabe Y, Bruellman RJ, Ebrhim RS, Abdullah MA, Dumitrescu AM, Refetoff S, Weiss RE. Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families. Thyroid. 2019;29(2):302-4. Watanabe Y, Ebrhim RS, Abdullah MA, Weiss RE. A Novel Missense Mutation in the SLC5A5 Gene in a Sudanese Family with Congenital Hypothyroidism. Thyroid. 2018;28(8):1068-70. Weitz JR, Makhmutova M, Almaca J, Stertmann J, Aamodt K, Brissova M, Speier S, Rodriguez-Diaz R, Caicedo A. Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity. Diabetologia. 2018;61(1):182-92.

D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2019

GASTROENTEROLOGY-HEPATOLOGY Bhamidimarri KR, Martin P. Are High-Dose Steroids Really Necessary in Treatment of Autoimmune Hepatitis? Clin Gastroenterol Hepatol. 2019 Sep;17(10):1948-1949. Carrion AF, Martin P. When to Refer for Liver Transplantation. Am J Gastroenterol. 2019;114(1):7-10. Jadoul M, Bieber BA, Martin P, Akiba T, Nwankwo C, Arduino JM, Goodkin DA, Pisoni RL. Prevalence, incidence, and risk factors for hepatitis C virus infection in hemodialysis patients. Kidney Int. 2019;95(4):939-47. Martin P. Immunetolerant Hepatitis B: Maybe a misnomer but still hard to treat. Hepatology. 2019 Jun;69(6):2315-2317.

GENERAL INTERNAL MEDICINE Carrasquillo O, Mueller M. Refinement of the Affordable Care Act: A Progressive Perspective. Annu Rev Med. 2018;69:29-39. Carrasquillo O, Seay J, Amofah A, Pierre L, Alonzo Y, McCann S, Gonzalez M, Trevil D, Koru-Sengul T, Kobetz E. HPV Self-Sampling for Cervical Cancer Screening Among Ethnic Minority Women in South Florida: a Randomized Trial. J Gen Intern Med. 2018;33(7):1077-83. Wo SR, Largent EA, Brosco J, Rosenberg AR, Goodman KW, Lantos JD. Should Foreigners Get Costly Lifesaving Treatments in the United States? Pediatrics. 2018;142(5).

HEMATOLOGY Alderuccio JP, Zhao W, Desai A, Ramdial J, Gallastegui N, Kimble E, de la Fuente MI, Husnain M, Rosenblatt JD, Alencar AJ, Schatz JH, Moskowitz CH, Chapman JR, Vega F, Reis IM, Lossos IS. Short survival and frequent transformation in extranodal marginal zone lymphoma with multiple mucosal sites presentation. Am J Hematol. 2019;94(5):585-96.

Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. J Clin Oncol. 2019;37(8):677-87. Dahi PB, Moskowitz CH, Giralt SA, Lazarus HM. Novel agents may positively impact chemotherapy and transplantation in subsets of Diffuse Large B-cell Lymphoma. Expert Rev Hematol. 2019 Jun;12(6): 407-418. Dahi PB, Moskowitz CH, Giralt SA, Lazarus HM. Novel agents positively impact chemotherapy and transplantation in Hodgkin lymphoma. Expert Rev Hematol. 2019;12(4):255-64. de la Fuente MI, Alderuccio JP, Reis IM, Omuro A, Markoe A, Echegaray JJ, Davis JL, Harbour JW, Lossos IS. Bilateral radiation therapy followed by methotrexate-based chemotherapy for primary vitreoretinal lymphoma. Am J Hematol. 2019;94(4):455-60. Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis. Cancer Cell. 2018;33(6):1111-27 e5. Guo Y, Zhou Y, Yamatomo S, Yang H, Zhang P, Chen S, Nimer SD, Zhao ZJ, Xu M, Bai J, Yang FC. ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis. Leukemia. 2019;33(5):1287-91. Hill BT, Nastoupil L, Winter AM, Becnel MR, Cerhan JR, Habermann TM, Link BK, Maurer MJ, Fakhri B, Reddy P, Smith SD, Mukhija D, Jagadeesh D, Desai A, Alderuccio JP, Lossos IS, Mehra P, Portell CA, Goldman ML, Calzada O, Cohen JB, Hussain MJ, Ghosh N, Caimi P, Tiutan T, Martin P, Kodali A, Evens AM, Kahl BS. Maintenance rituximab or observation after frontline treatment with bendamustine-rituximab for follicular lymphoma. Br J Haematol. 2019;184(4):524-35. 30

Kumar A, Ying Z, Alperovich A, Dogan A, Hamlin P, Moskowitz C, Pichardo J, Portlock C, Sha F, Zelenetz AD, Zhang Z, Drill E, Woo K, Younes A. Clinical presentation determines selection of patients for initial observation in mantle cell lymphoma. Haematologica. 2019;104(4):e163-e6. Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang JY, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L, Sun XJ. Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis. Proc Natl Acad Sci U S A. 2019;116(3):890-9. Lossos C, Liu Y, Kolb KE, Christie AL, van Scoyk A, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM. Mechanisms of lymphoma clearance induced by high-dose alkylating agents. Cancer Discov. 2019 Jul;9(7):944-961. Mackrides N, Chapman J, Larson MC, Ramos JC, Toomey N, Lin P, Maurer MJ, Rafaelle M, Tan Y, Ikpatt O, Syrbu S, Ansell SM, Habermann TM, Link BK, Feldman AL, Lossos IS, Cerhan JR, Vega F. Prevalence, clinical characteristics and prognosis of EBV-positive follicular lymphoma. Am J Hematol. 2019;94(2):E62-E4. Phillips AA, Fields PA, Hermine O, Ramos JC, Beltran BE, Pereira J, Wandroo F, Feldman T, Taylor GP, Sawas A, Humphrey J, Kurman M, Moriya J, Dwyer K, Leoni M, Conlon K, Cook L, Gonsky J, Horwitz SM, Study G. Mogamulizumab versus investigatorâ&#x20AC;&#x2122;s choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma. Haematologica. 2019;104(5):993-1003. Taylor J, Pavlick D, Yoshimi A, Marcelus C, Chung SS, Hechtman JF, Benayed R, Cocco E, Durham BH, Bitner L, Inoue D, Chung YR, Mullaney K, Watts JM, Diamond EL, Albacker LA, Mughal TI, Ebata K, Tuch BB, Ku N, Scaltriti M, Roshal M, Arcila M, Ali S, Hyman DM, Park JH, Abdel-Wahab O. Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies. J Clin Invest. 2018;128(9):3819-25.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d’Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DKt, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ. Functional genomic landscape of acute myeloid leukaemia. Nature. 2018;562(7728):526-31. Vardhana S, Cicero K, Velez MJ, Moskowitz CH. Strategies for Recognizing and Managing ImmuneMediated Adverse Events in the Treatment of Hodgkin Lymphoma with Checkpoint Inhibitors. Oncologist. 2019;24(1):86-95. Zhang MM, Liu N, Zhang YL, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L, Huang QH, Sun XJ. Destabilization of AETFC through C/EBPalpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation. Leukemia. 2019 Jul;33(7):1822-1827.

INFECTIOUS DISEASES Anjan S, Morillas J, Simkins J, Martinez OV, Holung M, Prado C, Jimenez A, Lekakis LJ, Komanduri K, Morris MI, Camargo JF. Saddle Nose Deformity in an Immunosuppressed Patient. Clin Infect Dis. 2019;68(4):705-9.

Fatukasi TV, Edmonds A, Gustafson DR, Cole SR, Edwards JK, Bolivar H, Cohen M, Fischl MA, Gange S, Konkle-Parker D, Moran CA, Plankey M, Sharma A, Tien PC, Adimora AA. Prevalence and 1-year incidence of frailty among women with and without HIV in the Women’s Interagency HIV Study. AIDS. 2019;33(2): 357-9. Holt GE, Kett D, Goodman KW. More on an Unconscious Patient with a DNR Tattoo. N Engl J Med. 2018;378(9):876-7. Hooton TM, Vecchio M, Lotan Y. Delivery of Bottled Water to Women With Recurrent Urinary Tract Infections: Why in Bulgaria?-Reply. JAMA Intern Med. 2019;179(3):449. Low M, Neuberger A, Hooton TM, Green MS, Raz R, Balicer RD, Almog R. Association between urinary community-acquired fluoroquinolone-resistant Escherichia coli and neighbourhood antibiotic consumption: a population-based case-control study. Lancet Infect Dis. 2019;19(4):419-28. Mullane KM, Winston DJ, Nooka A, Morris MI, Stiff P, Dugan MJ, Holland H, Gregg K, Adachi JA, Pergam SA, Alexander BD, Dubberke ER, Broyde N, Gorbach SL, Sears PS. A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile-associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation. Clin Infect Dis. 2019;68(2):196-203. Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Koves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2019 May 2;68(10):e83-e110.

Camargo JF, Wieder ED, Kimble E, Benjamin CL, Kolonias DS, Kwon D, Chen XS, Komanduri KV. Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation. Blood. 2019;133(8):867-77.

D epartmen t o f Medic in e C h air man ’s R e po r t 2019

Silver ZA, Dickinson GM, Seaman MS, Desrosiers RC. A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection. J Virol. 2019;93(10). Sundermann AJ, Clancy CJ, Pasculle AW, Liu G, Cumbie RB, Driscoll E, Ayres A, Donahue L, Pergam SA, Abbo L, Andes DR, Chandrasekar P, Galdys AL, Hanson KE, Marr KA, Mayer J, Mehta S, Morris MI, Perfect J, Revankar SG, Smith B, Swaminathan S, Thompson GR, Varghese M, Vazquez J, Whimbey E, Wingard JR, Nguyen MH. How Clean Is the Linen at My Hospital? The Mucorales on Unclean Linen Discovery Study of Large United States Transplant and Cancer Centers. Clin Infect Dis. 2019;68(5):850-3. Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martinez-Romero C, Garcia-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 2018;4:31.

NEPHROLOGY Burke GW, 3rd, Fornoni A. The elusive podocyte crossmatch for recurrent focal segmental glomerulosclerosis. Kidney Int. 2019;95(3):498-500. Canetta PA, Troost JP, Mahoney S, Kogon AJ, Carlozzi N, Bartosh SM, Cai Y, Davis TK, Fernandez H, Fornoni A, Gbadegesin RA, Herreshoff E, Mahan JD, Nachman PH, Selewski DT, Sethna CB, Srivastava T, Tuttle KR, Wang CS, Falk RJ, Gharavi AG, Gillespie BW, Greenbaum LA, Holzman LB, Kretzler M, Robinson BM, Smoyer WE, Guay-Woodford LM, Reeve B, Gipson DS, Cure GNC. Health-related quality of life in glomerular disease. Kidney Int. 2019;95(5):1209-24.

POPULATION HEALTH Moore KJ, Caban-Martinez AJ, Kirsner RS, SchaeferSolle N, Lee DJ, Koru-Sengul T, Kobetz EN. Firefighter Skin Cancer and Sun Protection Practices: Evidence From the Florida Firefighter Cancer Initiative. JAMA Dermatol. 2018;154(2):219-21.

MEDICAL ONCOLOGY

PULMONARY

Aguiar PN, Jr., Perry LA, Penny-Dimri J, Babiker H, Tadokoro H, de Mello RA, Lopes GL, Jr. The effect of PD-L1 testing on the cost-effectiveness and economic impact of immune checkpoint inhibitors for the second-line treatment of NSCLC. Ann Oncol. 2018;29(4):1078.

Haworth CS, Bilton D, Chalmers JD, Davis AM, Froehlich J, Gonda I, Thompson B, Wanner A, Oâ&#x20AC;&#x2122;Donnell AE. Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase 3, randomised controlled trials. Lancet Respir Med. 2019;7(3):213-26.

Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W. Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1. Gastroenterology. 2019;156(3): 662-75 e7. Weekes C, Lockhart AC, Lee JJ, Sturm I, Cleton A, Huang F, Lenz HJ. A phase 1b study evaluating the safety and pharmacokinetics of regorafenib in combination with cetuximab in patients with advanced solid tumors. Int J Cancer. 2019 Nov 1;145(9):2450-2458.

Nathan SD, Costabel U, Glaspole I, Glassberg MK, Lancaster LH, Lederer DJ, Pereira CA, Trzaskoma B, Morgenthien EA, Limb SL, Wells AU. Efficacy of Pirfenidone in the Context of Multiple Disease Progression Events in Patients With Idiopathic Pulmonary Fibrosis. Chest. 2019;155(4):712-9.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Rangarajan S, Bone NB, Zmijewska AA, Jiang S, Park DW, Bernard K, Locy ML, Ravi S, Deshane J, Mannon RB, Abraham E, Darley-Usmar V, Thannickal VJ, Zmijewski JW. Metformin reverses established lung fibrosis in a bleomycin model. Nat Med. 2018;24(8):1121-7.

RHEUMATOLOGY Ascherman DP, Zang Y, Fernandez I, Clark ES, Khan WN, Martinez L, Greidinger EL. An Autoimmune Basis for Raynaudâ&#x20AC;&#x2122;s Phenomenon: Murine Model and Human Disease. Arthritis Rheumatol. 2018;70(9):1489-99. Chang AY, Martins KAO, Encinales L, Reid SP, Acuna M, Encinales C, Matranga CB, Pacheco N, Cure C, Shukla B, Ruiz Arteta T, Amdur R, Cazares LH, Gregory M, Ward MD, Porras A, Rico Mendoza A, Dong L, Kenny T, Brueggemann E, Downey LG, Kamalapathy P, Lichtenberger P, Falls O, Simon GL, Bethony JM, Firestein GS. Chikungunya Arthritis Mechanisms in the Americas: A Cross-Sectional Analysis of Chikungunya

Arthritis Patients Twenty-Two Months After Infection Demonstrating No Detectable Viral Persistence in Synovial Fluid. Arthritis Rheumatol. 2018;70(4):585-93. England BR, Duryee MJ, Roul P, Mahajan TD, Singh N, Poole JA, Ascherman DP, Caplan L, Demoruelle MK, Deane KD, Klassen LW, Thiele GM, Mikuls TR. Malondialdehyde-Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis-Interstitial Lung Disease. Arthritis Rheumatol. 2019 Sep;71(9):1483-1493. Sciorati C, Monno A, Doglio MG, Rigamonti E, Ascherman DP, Manfredi AA, Rovere-Querini P. Exacerbation of Murine Experimental Autoimmune Myositis by Toll-Like Receptor 7/8. Arthritis Rheumatol. 2018;70(8):1276-87.

INTRODUCING THE DIVISION OF TRANSPLANTATION AND CELLULAR THERAPY In the 2019-2020 academic year the Department of Medicine will welcome the newly created Division of Transplantation and Cellular Therapy. This specialization helps patients in need of bone marrow and stem cell transplants, which treat blood cancers, diseases of the immune system and other conditions. Headed by Dr. Krishna Komanduri, MD, the division will develop leading-edge technologies in this field, including translational, clinical and outcomes research and the development of novel pharmacologic and cellular therapies. D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2019

Dr. Komanduri is the Kalish Family Chair in Stem Cell Transplantation, the Director of the Adult Stem Cell Transplant Program and the Associate Chief Medical Officer for Clinical Innovation at the Sylvester Comprehensive Cancer Center. He will be joined by other physicians and researchers to create a clinical presence with full oncological care support, a robust and innovative research program and the finest transplantation and cellular therapy training for medical students, residents and fellows.

CARDIOVASCULAR

CLINICAL PHARMACOLOGY

HEPATOLOGY SECTION Professors of Medicine Paul Martin, MD Eugene R. Schiff, MD Assistant Professors of Medicine Leopoldo B. Arosemena, MD Patricia D. Jones, MD, MSCR Eric F. Martin, MD

Jeffrey Goldberger, MD, MBA Division Chief

Richard A. Preston, MD Division Chief

Professor of Clinical Medicine Christopher B. Oâ&#x20AC;&#x2122;Brien, MD

Professors of Medicine Simon C. Chakko, MD Mauricio G. Cohen, MD Eduardo J. De Marchena, MD Chunming Dong, MD Jeffrey Goldberger, MD, MBA Joshua M. Hare, MD Robert J. Myerburg, MD Rafael F. Sequeira, MD

Professors of Medicine Barry Materson, MD (Emeritus) Richard A. Preston, MD

Associate Professor of Clinical Medicine Kalyan R. Bhamidimarri, MD, MPH Cynthia Levy, MD

Associate Professor of Medicine David Afshartous, MD

ENDOCRINOLOGY, DIABETES & METABOLISM

Staff Physician Rtika Abraham, MD Research Professor of Medicine, Immunology and Microbiology Ricardo Pastori, PhD Research Associate Professors Renzhi Cai, PhD Alejandro Diego Caicedo-Vierkant, PhD Tengjiao Cui, PhD Armando Mendez, PhD Research Assistant Professors Joana Almaca, PhD Rene Barro-Soria, PhD Manuel Blandino, PhD Lisa Rafkin, PhD Rayner Rodriguez-Diaz, PhD

GENERAL INTERNAL MEDICINE

DIGESTIVE HEALTH AND LIVER DISEASES

Associate Professors of Medicine Martin S. Bilsker, MD Lina Shehadeh, PhD Assistant Professor of Medicine Jian Wei, PhD Professors of Clinical Medicine Maureen H. Lowery, MD Raul Mitrani, MD Associate Professors of Clinical Medicine Carlos E. Alfonso, MD Eugene J. Bauerlein, MD Sandra Chaparro, MD Claudia A. Martinez-Bermudez, MD Carl E. Orringer, MD Alan H. Schob, MD David M. Seo, MD Assistant Professors of Clinical Medicine Sharon N. Andrade-Bucknor, MD Antonio Barquet-Leon, MD Michael Dyal, MD George Marzouka, MD Roberto A. Miki, MD Litsa K. Lambrakos, MD Nina Rivera, DO Robert B. Stang, MD Alex Velasquez, MD

Ernesto Bernal-Mizrachi, MD Division Chief Paul Martin, MD Division Chief

GASTROENTEROLOGY SECTION Professors of Medicine Maria T. Abreu, MD Jaime S. Barkin, MD Jeffrey B. Raskin, MD (Emeritus) Associate Professors of Medicine Amar Deshpande, MD Jose Garrido, MD David H. Kerman, MD Daniel Sussman, MD, MPH Assistant Professors of Medicine Jodie A. Barkin, MD Andres Monsalve Carrion, MD Oriana Damas, MD Paul Feldman, MD Roberto Fogel, MD Mohit Girotra, MD Marcelo Larsen, MD, FACG Emory Manten, MD Il Joon Paik, MD Michelle Pearlman, MD Enrico Souto, MD Clinical Instructor Mona Rezapour, MD

Professors of Medicine Rodolfo Alejandro, MD Ernesto Bernal-Mizrachi, MD Ronald Goldberg, MD Karl Muench, MD Alberto Pugliese, MD Jay Skyler, MD Jay Sosenko, MD Roy E. Weiss, MD, PhD Assistant Professor of Medicine David Baidal, MD Professors of Clinical Medicine Rajesh Garg, MD Gianluca Iacobellis, MD, PhD Associate Professors of Clinical Medicine Alejandro Ayala, MD Atil Kargi, MD Violet Lagari-Libhaber, DO Assistant Professors of Clinical Medicine Zeina Hannoush, MD Mark Jara, MD Jason Levine, DPM Silvia Gra Menendez, MD Bresta Miranda-Palma, MD Marcela Perez-Bustamante, MD Maria del Pilar Solano, MD Rodrigo Valderrabano, MD Francesco Vendrame, MD, PhD

Olveen Carrasquillo, MD, MPH Division Chief Professor of Medicine Olveen Carrasquillo, MD, MPH Professors of Clinical Medicine Panagiota Caralis, MD, JD Laurence Gardner, MD S. Barry Issenberg, MD Daniel Lichtstein, MD Alex Mechaber, MD Associate Professors of Clinical Medicine Keith Custer, MD Yvonne Diaz, MD Mark Gelbard, MD Marco Gonzalez, MD Erin Marcus, MD, MPH Hilit Mechaber, MD Paul Mendez, MD Ross Scalese, MD Joan St. Onge, MD Frederick Williams, MD Assistant Professors of Clinical Medicine Gauri Agarwal, MD Howard Anapol, MD Stephen Avallone, MD Monica Broome, MD Stefanie Brown, MD Alexandra Calandriello, MD

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Manuela Calvo, MD Gregory Coleman, MD Gloria Coronel-Couto, MD Yanisa Del Toro, MD Antonia Eyssallenne, MD, PhD Annette Fornos, MD Sherin Ghali, MD Elizabeth Greig, MD Lilliam Guzman, MD Brian Hagenlocker, MD Melanie Helfman, MD Margarita Llinas, MD Sudha Lolayekar, MD Elizabeth Parra-Garnica, MD Cristina Pravia, MD Hiram Rodriguez, MD Stacy Rubin, MD Anjali Saxena, MD Maritza Suarez, MD Jacobo Wajner, MD Kendra Van Kirk, MD Amalinnette Zito, MD Research Professor Kenneth Goodman, PhD Research Associate Professor Chi Zhang, PhD

Assistant Professors of Clinical Medicine Enrique Aguilar, MD Joel Danisi, MD Jenny Drice, MD Mariana Khawand-Azoulai, MD Osvaldo Rodriguez, MD Julia Sanchez, MD Luis Samos-Gutierrez, MD Marcio Rotta Soares, MD Karin Zachow, MD Khin Zaw, MD Research Professor Guy Howard, PhD Research Associate Professor Jorge Ruiz, MD Research Assistant Professor Miriam Gutt, PhD Associate Professor of Professional Practice Maria Rose van Zuilen, PhD

HEMATOLOGY

Assistant Professors of Clinical Medicine Juan Pablo Alderuccio, MD Alvaro Alencar, MD Ney Alves, MD Terrence Bradley, MD Roberto Cano, MD Jonathan Cohen, MD Thomas Harrington, MD James Hoffman, MD Antonio Jimenez, MD Lazaros Lekakis, MD Denise Pereira, MD Trent Wang, MD Steven Weiss, MD

Research Assistant Professors Cara Benjamin, PhD Xiaoyu Jiang, PhD Ye Xu, PhD Yu Zhang, M.D.

Marcio Rotta Soares, MD Division Chief Professors of Medicine Silvina Levis-Dusseau, MD Bernard Roos, MD (Emeritus) Bruce Troen, MD (Emeritus) Michael Mintzer, MD (Emeritus) Associate Professors of Clinical Medicine Stuti Dang, MD, MPH Jorge Ruiz, MD Carlos Perez-Stable, PhD

Joseph D. Rosenblatt, MD Division Chief Professors of Medicine Yeon Soong Ahn, MD (Emeritus) John Byrnes, MD Krishna Komanduri, MD Izidore Lossos, MD Craig Moskowitz, MD Stephen Nimer, MD Joseph D. Rosenblatt, MD Assistant Professors of Medicine Marzenna Blonska, PhD Justin Watts, MD Associate Professors of Clinical Medicine Amer Beitinjaneh, MD Mark Goodman, MD Juan Carlos Ramos, MD Jonathan Schatz, MD

D epartmen t o f Medic in e C h air man â&#x20AC;&#x2122;s R e po r t 2019

Mario Stevenson, PhD Division Chief Professors of Medicine Gordon Dickinson, MD Margaret Fischl, MD Michael Kolber, MD Mario Stevenson, PhD Professors of Clinical Medicine Gio Baracco, MD Jose Castro, MD Thomas Hooton, MD Michele Morris, MD Allan Rodriguez, MD Dushyantha Jayaweera, MD

Assistant Professor of Professional Practice Adrian Reynolds, PhD

GERIATRICS & PALLIATIVE MEDICINE

INFECTIOUS DISEASES

Research Associate Professors Wenche Jy, PhD Seung-Uon Shin, PhD Ramiro Verdun, PhD Eric Wieder, PhD

HOSPITAL MEDICINE

Research Assistant Professor Sonjia Kenya, PhD

Wassim Samra, MD Joao Miguel Serigado Soares Da Costa, MD Keren Shahar, MD Piotr Tabaczewski, MD Olga Tarasova, MD Venkata Thammineni, MD Asaad Trabolsi, MD Pamela Trotter, MD Jessica Zuleta, MD

Erick Palma, MD Interim Division Chief Associate Professor of Clinical Medicine Efren Manjarrez, MD Assistant Professors of Clinical Medicine Beatrice Alvarado-Roberts Tanya Clarke, MD Maria Carolina Delgado-Lelievre, MD Jorge Diaz Valdes, MD Iman Doostan, MD Kunal Gawri, MD Jorge Florindez, MD Chadwick Flowers, MD Matthew Imm, MD Rafael Enrique Hernandez Oquet, MD Armen Henderson, MD Maria Antonietta Mosetti, MD Deepak Mummidavarapu, MD Erick Palma, MD Brent Parris, MD Aldo Pavon Canseco, MD Carla Rabassa, MD Allan Rubinfeld, MD

Associate Professors of Clinical Medicine Lilian Abbo, MD Maria Alcaide, MD Catherine Boulanger, MD Susanne Doblecki-Lewis, MD Paola Lichtenberger, MD Isabella Rosa-Cunha, MD Stephen Symes, MD Assistant Professors of Clinical Medicine Shweta Anjan, MD Folusakin Ayoade, MD Hector Bolivar, MD Jose Camargo, MD Christina Cloke, MD Jose Gonzales Zamora, MD Yoichiro Natori, MD Alexis Powell, MD Antoine Salloum, MD Jacques Simkins-Cohen, MD Candice Sternberg, MD Hansel Tookes, MD Research Assistant Professor Mark Sharkey, PhD

MEDICAL ONCOLOGY

Albert Craig Lockhart, MD Division Chief Professors of Medicine Bach Ardalan, MD Pasquale Benedetto, MD Lynn Feun, MD Marc Lippman, MD (Emeritus) Albert Craig Lockhart, MD Stephen Richman, MD (Emeritus) Joyce Slingerland, MD Jonathan Trent, MD, PhD Associate Professor of Medicine Jaime Merchan, MD Professors of Clinical Medicine Judith Hurley, MD Charles Vogel, MD Associate Professors of Clinical Medicine Gina Dâ&#x20AC;&#x2122;Amato, MD Richa Dawar, MD Peter Hosein, MD Chukwuemeka Ikpeazu,MD Gilberto Lopes, MD, MBA, FAMS Alejandra Perez, MD Catherine Welsh, MD Assistant Professors of Clinical Medicine Carmen Calfa, MD Reshma Mahtani, DO Lawrence Negret, MD Cesar Perez, MD Agustin Pimentel, MD Pearl Seo, MD Frances Valdes-Albini, MD Luis Villa, M.D. Research Professor Niramol Savaraj, MD Research Associate Professor Priyamvada Rai, PhD Staff Physicians Rakesh Singal, MD Gustavo Fernandez, MD

KATZ FAMILY DIVISION OF NEPHROLOGY AND HYPERTENSION

POPULATION HEALTH AND COMPUTATIONAL MEDICINE

Alessia Fornoni, MD, PhD Division Chief

David M. Seo, MD Division Chief

Professor of Medicine Alessia Fornoni, MD, PhD David Roth, MD

Professors of Medicine Erin Kobertz, PhD, MPH David M. Seo, MD

Professors of Clinical Medicine Gabriel Contreras, MD, MPH Warren Kupin, MD Oliver Lenz, MD, MBA Ivonne Schulman, MD

Professors of Clinical Medicine Ana Palacio, MD, MPH Leonardo Tamariz, MD, MPH

Associate Professors of Clinical Medicine Giselle Guerra, MD Jair Munoz Mendoza, MD Mariella Ortigosa-Goggins, MD Marco Ladino Avellaneda, MD Assistant Professors of Clinical Medicine Adriana Dejman, MD Yelena Drexler, MD Adela Mattiazzi, MD Zain Mithani, MD Javier Pagan, MD Marie Anne Sosa, MD Research Associate Professor of Medicine Sandra Merscher, Ph.D.

Research Assistant Professors Julia Seay, PhD Natasha Solle, PhD

PULMONARY, CRITICAL CARE AND SLEEP MEDICINE

Alejandro D. Chediak, MD Interim Division Chief Professors of Medicine Horst J. Baier, MD (Emeritus) Matthias A. Salathe, MD (Emeritus) Roland M. Schein, MD Adam Wanner, MD Assistant Professor of Medicine Gregory E. Holt, MD, PhD Professors of Clinical Medicine Marilyn K. Glassberg, MD Daniel H. Kett, MD Andrew Quartin, MD Shirin Shafazand, MD, MS Associate Professors of Clinical Medicine Michael A. Campos, MD Alejandro D. Chediak, MD Elio Donna, MD Hayley B. Gershengorn, MD Neeraj Sinha, MD

Assistant Professors of Clinical Medicine Alexandre R. Abreu, MD Roger A. Alvarez, DO Sixto Alejandro Arias, MD Jonathan Auerbach, MD Yaroslav Buryk, MD Jorge L. Cabrera, DO Rafael Calderon-Candelario, MD, MSc David J. De La Zerda, MD Belen Esparis, MD Lesley A. Farquharson, MD Tanira B. Ferreira, MD Sergey Gerasim, MD Eric Lang, MD Mehdi Mirsaeidi, MD, MPH Erick A. Palma, MD Yoslay Perez, MD Rene Rico, MD David Romero-Fischmann, MD Waleed Sneij, MD Maria G. Tupayachi-Ortiz, MD Research Assistant Professor Eliana P. Mendes

RHEUMATOLOGY AND IMMUNOLOGY

Eric L. Greidinger, MD Division Chief Professor of Clinical Medicine Carlos J. Lozada, MD Associate Professors of Clinical Medicine Eric L. Greidinger, MD Elaine C. Tozman, MD Larry Young, MD Assistant Professors of Clinical Medicine Gustavo Carbone, MD Maria F. Carpintero, MD Elana Oberstein, MD Ozlem Pala, MD Christine Savage, MD Staff Physician Schartess Culpepper-Pace, MD

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sc hool of Med i c i ne

Philanthropy

UNIVERSITY OF MIAMI LEADERSHIP President: Julio Frenk, MD, MPH, PhD CEO, UHealth and EVP of Health Affairs: Edward Abraham, MD Dean and Chief Academic Officer: Henri R. Ford, MD, MHA

Funding from individuals and other entities help us fund groundbreaking research and important community initiatives. 0.1%

DEPARTMENT LEADERSHIP

WHO IS PART OF OUR TEAM? Fund Source

6% USD

Individuals.................................................................. 2,813,250.00 Foundations............................................................... 1,012,974.26 UM Alumni Donors........................................................ 480,565.99 Corporations................................................................. 271,806.08 Associations...................................................................... 5,153.09 Grand Total............................................................. 4,583,749.42

11%

61%

22%

Donor Levels # Donors % Donors $1,000,000+.............................1............................................... 1% $200,000+................................5............................................... 5% $100,000+................................3............................................... 3% $50,000+..................................6............................................... 5% $25,000+..................................6............................................... 5% $10,000+................................25............................................. 23% $1,000+..................................65 ............................................ 58% Total...................................... 111........................................100%

DIVISION CHIEFS Cardiovascular: Jeffrey Goldberger, MD, MBA Clinical Pharmacology: Richard Preston, MD, MSPH, MBA Endocrinology, Diabetes and Metabolism: Ernesto Bernal-Mizrachi, MD Digestive Health and Liver Diseases: Paul Martin, MD General Internal Medicine: Olveen Carrasquillo, MD, MPH Geriatrics and Palliative Medicine: Marcio Soares, MD Hematology: Joseph Rosenblatt, MD Hospital Medicine: Erick Palma, MD (Interim) Infectious Diseases: Mario Stevenson, PhD Medical Oncology: Craig Lockhart, MD Katz Family Division of Nephrology and Hypertension: Alessia Fornoni, MD, PhD Population Health and Computational Medicine: David Seo, MD Pulmonary, Critical Care and Sleep Medicine: Alejandro Chediak, MD (interim) Rheumatology and Immunology: Eric Greidinger, MD Transplantation and Cellular Therapy: Krishna Komanduri, MD

4% 6% 6%

27%

6% 8% 17%

9% 17%

WHAT HAVE OUR DONORS HELPED US FUND? Fund Allocation

USD

Divisional Initiatives*........................................................................................................... 1,256,449.42 The Katz Family Division of Nephrology and Hypertension Endowed Operating Fund............ 800,000.00 Endowed Professorship in Nephrology and Hypertension Research........................................ 800,000.00 Nephrology Faculty Recruitment and Retention Fund............................................................. 400,000.00 IDEA Exchange’s Harm Reduction Education and Outreach Fund........................................... 351,300.00 Wallace H Coulter Research Fund............................................................................................ 265,000.00 The Division of Nephrology Research Fund............................................................................. 261,000.00 Terry and Cynthia Taylor Rheumatology Research Fund.......................................................... 250,000.00 Thyroid Dysfunction Research Fund......................................................................................... 200,000.00 Grand Total.................................................................................................................. 4,583,749.42 *including the Crohn’s and Colitis Center, Arrythmia Research Fund and the Barry J. Materson Endowed Featured Speaker Series in Hypertension D epartmen t o f Medic in e C h air man ’s R e po r t 2019

Chair: Roy Weiss, MD, PhD Vice Chair for Administration: Anna Carol Herman-Giddens, RN, BSN Vice Chair for Appointments, Promotion and Tenure: Oliver Lenz, MD, MBA Vice Chair for Clinical Affairs: Michael Kolber, MD, PhD Vice Chair for Education: Amar Deshpande, MD Vice Chair for Innovation and Diversity: Marilyn Glassberg, MD Vice Chair for Research: Maria Abreu, MD Associate Vice Chair for Quality: Maritza Suarez, MD Executive Director, Clinical Operations: Carlos Prieto Executive Director, Finance: Andres P. Macia Director, Finance: Ivelisse Rodriguez Director, Business Operations: Laura J. Pinzon Director, Research Support: Ilse Duarte Department Administrator: Jannet Yern

DIVISION ADMINISTRATION Cardiovascular: Jennette Prieto Endocrinology, Diabetes and Metabolism: Cristina Calderon-Parra Digestive Health and Liver Diseases: Carol Cottrell General Internal Medicine: Sarah Quadri Geriatrics and Palliative Medicine: Robert Morales (Interim) Hematology: Ali Ismail Hospital Medicine: Robert Morales (Interim) Infectious Diseases: Maria Piega Medical Oncology: Iliana Vera Katz Family Division of Nephrology and Hypertension: Andres Zurita-Lopez Population Health and Computational Medicine: Priscilla Acosta Pulmonary, Critical Care and Sleep Medicine: Rolando Briceno Rheumatology and Immunology: Anouk Gachelin

University of Miami Health System delivers leading-edge patient care by top-ranked physicians. Powered by the Miller School of Medicine’s groundbreaking research and medical education, UHealth provides life-saving care. UHealth is a comprehensive network of six hospitals, two dozen outpatient facilities, 1,200 doctors, and more than 8,000 associates. As the region’s only university health system, UHealth is a vital component of the South Florida community.

Department of Medicine, Chairman’s Office Don Soffer Clinical Research Center Leonard M. Miller School of Medicine University of Miami 1120 NW 14th Street, Suite 310 Miami, FL 33136 305.243.9120 medicine.med.miami.edu