Chemistry AR 2012 by Green Print Centre at UNSW IT

School of Chemistry Annual Report 2012 Never Stand Still

Faculty of Science

School of Chemistry

CONTENTS

HEAD OF SCHOOL REPORT

Mission Statement

School of Chemistry Organisation Chart

School of Chemistry Committees – 2012

Academic Responsibilities

ACADEMIC STAFF

RESEARCH

Overview 2012

Research Highlights

School Postgraduate Seminars

School Seminars – Invited Speakers

TEACHING AND LEARNING

Overview

Honours Program

Postgraduate Programs and Courses

Postgraduate Research

Asia Pacific Institute of Nuclear Science Short Courses

Outreach Activities

Degrees Awarded

Scholarships

Practicum Students

Programs and Activities

STUDENTS

School of Chemistry Undergraduate Student Prizes

Postgraduate Student Awards and Prizes

Students of Chemistry Society

SCHOOL

Staff

Invited Lectures & Conference Presentations

Publications & Patents

Grants and Research Fellowships

Industry and Community Interaction

Undergraduate and Postgraduate Enrolments

Conference Presentations – Students

Conference Posters

SCHOOL VISITING COMMITTEE

OBITUARIES

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

SECTION 01 01 03

HEAD OF SCHOOL REPORT

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In 2012, the School of Chemistry continued to build on its strengths. With the Excellence in Research Australia assessment process for 2012 complete, the discipline of chemistry at UNSW was ranked as one of the top in the country with an overall rating of “5”, and the areas of both Analytical Chemistry and Macromolecular Chemistry also rated at “5”. Other measures of research success include the publication output in international journals and the amount of research funding, both of which increased significantly in 2012, confirming the growth in research occurring in the School. The School continued to grow in terms of staff numbers. We were fortunate to appoint Dr Neeraj Sharma as an AINSE fellow, continuing our ties with ANSTO. Scientia Professor Justin Gooding was recognized for his outstanding research contributions yet again with the award of the Royal Australian Chemical Institute R.H. Stokes Medal for Electrochemistry for 2012. A/ Prof Naresh Kumar was promoted to Professor, a welldeserved recognition of the significant contribution that Professor Kumar makes to the University in research, teaching and outreach. Professor Kumar was also awarded the UNSW Staff Award for Excellence in Community Outreach in 2012 and Dr Pall Thordarson was recognized for his important contribution to Health and Safety in the School with a commendation at the presentation of University staff excellence awards. The PhD students in the School made a tremendous contribution again this year. With the numbers of PhD students steady at 80, we graduated 14. The PhD students were successful with a number of awards at local and international conferences, showing off the talents and success of the School to a wide audience. The School had been working towards a new first year syllabus over 2011 (chaired by Dr Thordarson), and the new syllabus was introduced to the students in 2012. At the same time, the outcomes of the assessment review

process were also rolled out across all undergraduate courses of the School. The undergraduate student numbers continued to increase, with our higher level first year course intake growing to nearly 500 students, from a number of only 200 in 2006. 2012 also saw the introduction of a series of initiatives made possible by the generous bequest of the late Theo Howard. Two new programs, visits to regional high schools (organized by Dr Luke Hunter) and the UNSW Chemistry Video Competition (A/Prof Naresh Kumar) were a great success. Another initiative funded from the bequest was a visiting lectureship, and the first of these was held in 2012. The lectureship enables an outstanding academic from another institutions (typically international) to spend a few weeks in Chemistry at UNSW and provide some advanced undergraduate lectures to third year and honours students, along with a research seminar. The lectureship should encourage collaborations and interactions with academics from outside the School, and broaden our student’s horizons.

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The School has also continued to grow it’s community engagement by building strong links with the Science Teachers’ Association of NSW (STANSW). The School hosted high school students from a number of schools across Sydney as part of its School Visit program, and also hosted Year 10 work experience students

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2012 was a very busy year, with many successes and a significant commitment from all members of the School. I would like to thank all of the staff and students who have contributed enthusiastically to the continued success of the School in 2012.

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PROFESSOR BARBARA MESSERLE

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

School of Chemistry staff and research students

SECTION 01 Mission Statement The School of Chemistry aspires to continue as a leading chemistry School in the region.

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We aim to develop cutting edge knowledge to solve key challenges in the world today. Our research is focused in three research clusters Nanoscience, Medicinal Chemistry, and Catalysis and Energy. These research areas provide a base from which we take our research from the fundamentals of chemistry through to practical applications.

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We aim to excel in the education of our future scientific leaders and community members. We will continue to expand our interactions with institutions across the world, and build strong ties with our community, in particular industry and schools.

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Goals:

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In order to remain a leading School in the region in both

As a School we constantly seek to improve our

research and teaching, the School aims to grow to a

already high quality of teaching. We will achieve this

size of 30 academic staff over the next five years. The

by ensuring that the latest research developments in

growth will be targeted to maintain a balance of the three

chemistry are included in our curricula and that our

research clusters

teaching materials both challenge our undergraduate

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students and nurture their love of chemistry. By

To increase our research funding and broaden the

engaging the students we aim to promote their life long

funding base of the research groups we will target

learning of chemistry.

international funding schemes and industry support.

A key goal is to achieve high quality publications in

To lead debate, we plan to expand our influence in

leading international journals with continued growth in

the broader community. Our community engagement

terms of volume of output in publications with of higher

program will continue to target high schools across

impact. Postgraduate research students form the core of

NSW and we will develop a new approach to our

our research strength and we need to continue to grow

marketing strategy for students. We will grow the

the quality and number of our higher degree students,

level of interactions with our alumni and focus on the

with particular focus on attracting the best UNSW

inclusion of our alumni in the life of the School today.

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students and high quality international students into

postgraduate studies.

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

School of Chemistry Organisation Chart

Head of School

Deputy Head of School

Director of Research

Director of Teaching

Deputy Director of Teaching

School Manager

Office Administrator

Technical Staff

Stores

Postgraduate Coordinator

Academic Staff

Honours Coordinator

Postgraduate Administrator

Postdocs

1st Year Coordinator

Student Services Manager

Undergraduate Teaching Coordinators

Undergraduate Administrator

Postgraduate Coursework Coordinator

Outreach Coordinator

Technical & Building Manager

Marketing

SECTION 01 School of Chemistry Committees – 2012 01

School Executive Committee

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 A/Prof. John Stride

 Prof. Barbara Messerle (Chair)

 Dr Gavin Edwards

 Scientia Professor Justin Gooding

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School Advisory Committee

 Prof. Barbara Messerle (Chair)

 A/Prof. John Stride

 A/Prof. Jonathan Morris

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 A/Prof. Naresh Kumar

 A/Prof. Shelli McAlpine

 Dr Pall Thordarson

 Dr Gavin Edwards

 Dr Toby Jackson

 Mr Rick Chan

 Mr Sveto Videnovic/

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Research Committee

 A/Prof. John Stride (Chair)

Teaching Committee

 Dr Gavin Edwards (Chair)

Postgraduate Committee

 A/Prof. Jonathan Morris (Chair)

Outreach Committee

 A/Prof. Naresh Kumar (Chair)

Health & Safety Committee

 Dr Pall Thordarson (Chair)

Search Committee

 Prof. Barbara Messerle (Chair)

Building & Space Committee

 A/Prof. John Stride (Chair)

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Academic Responsibilities Responsibility

Staff Member

Director of Research

A/Prof. John Stride

Director of Teaching

Dr Gavin Edwards

Deputy Director of Teaching

Dr Jason Harper

Deputy Head of School

Scientia Professor Justin Gooding

Postgraduate Coordinator

A/Prof. Jonathan Morris

Honours Coordinator

A/Prof. Marcus Cole

Higher Year Coordinator (2-3rd year)

Dr Pall Thordarson

Higher Year Laboratory Coordinator

A/Prof. Steve Colbran

1st Year Coordinator

Dr Nick Roberts

1st Year Laboratory Coordinator

Dr Ron Haines

Postgraduate Coursework Coordinator

Prof. Brynn Hibbert

Degree Program Coordinators

A/Prof Jonathan Morris â&#x20AC;&#x201C; Medicinal Chemistry A/Prof. Marcus Cole- Nanotechnology

Seminar Coordinator

Dr Chuan Zhao

Outreach

A/Prof. Naresh Kumar

OHS

Dr Pall Thordarson

Dr Ron Haines

Scientia Prof. Justin Gooding, A/Prof Steve Colbran, Prof. David Black, Dr Chuan Zhao, Dr Jason Harper, Prof. Barbara Messerle (Head of School), Visiting Fellow A/Prof. Roger Read, Dr Leigh Aldous, Dr Luke Hunter, Visiting Fellow A/Prof. Mike James, Dr Neeraj Sharma, Dr Pall Thordarson, Dr Nick Roberts, Dr Ron Haines, A/Prof. Jonathan Morris

SECTION 02 01

Born in 1982, Dr Aldous completed his undergraduate degree at Leeds (2004) and

postgraduate work at Queen’s University, Belfast (2007). He became a Postdoctoral Fellow at

Queen’s University, Belfast (2007-2009), and then at The University of Oxford (2009 - 2011).

Royal Society of Chemistry (member).

Royal Australian Chemical Institute (member).

Invited Lectures, Conference and Media Presentations:

18 Australian Electrochemistry Conference, Perth, Australia (15th April 2012; presentation).

5th Australasian Symposium on Ionic Liquids (ASIL5), Melbourne, Australia (3rd May 2012; poster).

The 2012 International Conference on Nanoscience and Nanotechnology (ICONN), Perth, Australia (5-9th February 2012; presentation).

ACADEMIC STAFF Dr Leigh Aldous B.Sc (Hon), Leeds, CAST Ph.D. Queen’s University Belfast

Dr Aldous was appointed as a Lecturer at UNSW in 2011.

Current research Activities: Biomass and Ionic Liquids: Dissolution and conversion of biomass into sustainable chemical source Electroanalysis, with particular emphasis on nanomaterials Ionic Liquids and hydrogen storage.

Selected Publications: “Ionic Liquids for Lignin Processing: Dissolution, Isolation, and Conversion” M. M. Hossain; L. Aldous, Australian Journal of Chemistry 2012, 65, 1465-1477 “Clean, efficient electrolysis of formic acid via formation of eutectic, ionic mixtures with ammonium formate” L. Aldous; R. G. Compton, Energy & Environmental Science 2010, 3(10), 1587-1592. “The mechanism of hydrazine electro-oxidation revealed by platinum microelectrodes: role of residual oxides” L. Aldous; R. G. Compton, Physical Chemistry Chemical Physics 2011, 13(12), 5279-5287. “Towards Mixed Fuels: The Electrochemistry of Hydrazine in the Presence of Methanol and Formic Acid” L. Aldous; R. G. Compton, ChemPhysChem 2011, 12(7), 1280-1287.  “The electrochemistry of quinizarin revealed through its mediated reduction of oxygen” BatchelorMcAuley, C.; Dimov, I. B.; L. Aldous; R. G. Compton, Proceedings of the National Academy of Sciences of the United States of America 2011, 108(50), 1989119895.Professional Activities:

Professional Activities: International Society of Electrochemistry (member). Electrochemistry Society (member).

10th International Society of Electrochemistry (ISE) Spring Meeting, Perth, Australia (15th-18th April 2012; presentation).

BIT’s 2nd Annual World Congress on Nanoscience & Technology 2012, Qingdao, China (26th-28th October 2012; presentation). Curtin University of Technology, Perth, Australia (8th February 2012; seminar at the Department of Chemistry). National Cheng Kung University, Tainan, Taiwan (30th October 2012; seminar at the Department of Chemistry).

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Graham Edwin Ball B.Sc., Ph.D. Sheffield Born in 1965, Dr Ball completed his Undergraduate and Postgraduate work at the University of Sheffield gaining his B.Sc. (1986) and Ph.D. (1990). He became a Postdoctoral Fellow at the University of British Columbia (1990-91), and then at the University of California, Berkeley (1991-1994). Dr Ball was appointed University of New South Wales NMR Facility Manager and Adjunct Lecturer in 1995 and Senior Lecturer in 2005.

Current Research Activities:

Professional Activities:

Chemical and biological applications of NMR

RACI Inorganic Division, NSW Representative.

spectroscopy Characterisation of reactive intermediates in organometallic chemistry Computational chemistry Investigations of drug-DNA interactions Structure elucidation

Selected Publications: Young, R.D.; Lawes, D.J.; Hill, A.F.; Ball, G.E. “Observation of a tungsten alkane σ-complex showing selective binding of methyl groups using FTIR and NMR spectroscopies” J. Am. Chem. Soc., 2012, 134, 8294–8297. Young, R.D.; Hill, A.F.; Hillier, W.; Ball, G.E. “Transition Metal-Alkane σ-Complexes with Oxygen Donor Co-ligands” J. Am. Chem. Soc., 2011, 133, 1380613809. Ball, G.E.; Brookes, C.M.; Cowan, A.J.; Darwish, T.A; George, M.W.;. Kawanami, H.K.; Portius, P.; Rourke, J.P. “A delicate balance of complexation vs. activation of alkanes: NMR and TRIR studies of the interaction of alkanes with [Re(Cp)(CO)(PF3)].” Proc. Natl. Acad. Sci. USA., 2007, 104, 6927. Ball, G.E.; Darwish, T.A; Geftakis, S.; George, M.W.; Lawes, D.J.; Portius, P.; Rourke, J.P. “Characterization of an Organometallic Xenon Complex using NMR and IR Spectroscopy.” Proc. Natl. Acad. Sci. USA., 2005, 102, 1853. Geftakis, S.; Ball, G.E. “Direct Observation of a Transition Metal Alkane Complex, CpRe(CO)2(cyclopentane), Using NMR Spectroscopy,” J. Am. Chem. Soc., 1998, 120, 9953.

Invited Lectures, Conference and Media Presentations: Plenary Speaker, RACI Victorian Division Inorganic Chemistry Symposium, Melbourne, November 2012. Oral presentation, XXV International Conference on Organometallic Chemistry, Lisbon, Portugal, September 2012.

SECTION 02 Professor David St Clair Black M.Sc. Syd., Ph.D. Camb., AMusA, CChem, FRACI Born in 1938, Professor Black completed his postgraduate work at the University of Sydney (MSc, 1960) and then at the University of Cambridge (PhD, 1963). He was a Post Doctoral Research Associate at Columbia University (1963 – 1964). He was appointed as Lecturer at Monash University (1965), promoted to Senior Lecturer (1971) and Reader in Organic Chemistry (1975). He was appointed Professor of Organic Chemistry at the University of New

South Wales in 1983.

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Current Research Activities:

Professional Activities:

Synthetic organic chemistry including methods of

Secretary General, ICSU (2011-2014)

synthesis, heterocyclic chemistry (especially indole chemistry), photochemistry. Organic aspects of coordination chemistry including ligand design and synthesis, macrocycles, organometallic chemistry. Polymer chemistry - new polyamides, polyesters and modified peptides. Self-assembly studies involving hydrogen bonding. Development of mild and efficient new metal complex catalysts related to Green Chemistry. Natural products chemistry - constituents of Endiandra and Beilschmiedia species, indole alkaloids.

Selected Publications: Black, D. St.C., Editor, Science of Synthesis, Volume 15, Hetarenes and related ring systems: sixmembered hetarenes with one nitrogen or phosphorus atom, pub. Thieme Verlag, Stuttgart, 1320 pp (2004). Wahyuningsih, T. D., Kumar, N. and Black, D. StC., Synthesis of indolo[2,3-c]quinolines from 3- arylindole2-ketoximes, Tetrahedron, 63, 6713-6719 (2007).

External Examiner, University of Malaya, Kuala Lumpur, Malaysia Member of National Committee for Chemistry Member of NMI Reference Materials Review Committee, National Measurement Institute, Australian Government Analytical Laboratory.

Invited Lectures, Conference and Media Presentations: Black, D. StC., “Macrocyclic

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Tetraindolyls: Indorphyrins and related structures

as potential new foundation molecules”, Gordon

Conference on Heterocyclic Compounds, Salve

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Regina University, Newport, RI, USA, June 2012.

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Awards: Appointed Officer of the Order of Australia.

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Cheah, W. C., Black, D. StC., Goh, W. K. and Kumar, N., Synthesis of antibacterial peptidomimetics derived from N-acylisatins, Tetrahedron Letters, 49, 2965-2968 (2008).

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Chen, R., Bhadbhade, M., Kumar, N and Black, D. StC., Synthesis of cyclic tetraindolyls via oxidative coupling reactions, Tetrahedron Letters, 53, 33373341 (2012).

Somphol, K., Chen, R., Bhadbhade, M., Kumar, N. and Black, D. StC., A new strategy for calixindole formation: synthesis of a calix[3]indole with 2,2; 7,2; 7,7-methylene linkages and a new calix[4]indole with 2,2; 7,2; 7,7; 2,7-methylene linkages, Synlett, 24-28 (2013).

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Associate Professor Stephen Boyd Colbran B.Sc, Ph.D Otago Associate Professor Colbran gained his Ph.D from the University of Otago, New Zealand, in 1984. He then undertook post-doctoral research with Professor the Lord Jack Lewis, FRS, and Professor Brian Johnson, FRS, at the University Chemical Laboratories, University of Cambridge, England, 1984–1987. Steve was appointed to the academic staff of UNSW in 1987, and he spent 1994 on leave from UNSW as a Visiting Scientist in the Department of Chemistry, Massachusetts Institute of Technology, USA.

Current Research Activities: Transition metal chemistry with an emphasis on: Biological catalysis: using computational and synthetic models to uncover insights about multielectron redox processes in biology. Biomimetic catalysis: using biomimcry to prepare sophisticated catalysts for multi-electron reduction processes. Catalyses for a sustainable future: multi-electron reduction of unsaturated organic substrates to produce high-value chemicals and of carbon dioxide to selectively produce formaldehyde or methanol. Ligand ‘non-innocence’ in transition metal chemistry and its applications. Electrochemistry and spectro-electrochemistry applied to transition metal systems.

Selected Publications: McSkimming, A.; Bhadbhade, M. M.; Ball, G. E.; Colbran S. B., Rhodium complexes of a chelating ligand with imidazol-2-ylidene and pyridin-2-ylidene donors: the effect of C-metalation of nicotinamide groups on uptake of hydride ion, Inorganic Chemistry, 2012, 51, 2191–2203. McSkimming, A.; Bhadbhade, M. M.; Colbran S. B., Hydride ion-carrier ability in Rh(I) complexes of a nicotinamide-functionalised N-heterocyclic carbene ligand, Dalton Transactions, 2010, 39, 10581–10584. Rawling, T.; Austin, C.; Buchholz, F.; Colbran S .B.; McDonagh A. M., Ruthenium phthalocyaninebipyridyl dyads as sensitizers for dye-sensitized solar cells: Dye coverage versus molecular efficiency, Inorganic Chemistry, 2009, 48, 3215– 3227.

Moberg, V.; Mottaqlib, A. M.; Sauer, D.; Poplavskaya, Y.; Craig, D. C.; Deeming, A. J.; Colbran, S. B.; Nordlander, E., Chiral and achiral phosphine derivatives of alkylidyne tricobalt carbonyl clusters as catalysts for (asymmetric) inter- and intra-molecular Pauson-Khand reactions, Dalton Transactions, 2008, 2442–2453. Lonnon, D. G. Lee, S.-T.; Colbran S. B., Valence tautomerism and coordinative lability in copper(II)– imidazolyl–semiquinonate anion models for the CuB centre in cytochrome c oxidase, Journal of the American Chemical Society, 2007, 129, 5800-5801.

Professional Activities: Coordinator of Upper-level Laboratory Teaching for the School of Chemistry, UNSW Member of the Teaching Committee, School of Chemistry, UNSW Member of the Research Committee, School of Chemistry, UNSW Chair, Assessment Committee, School of Chemistry, UNSW Member of the Society of Biological Inorganic Chemistry (SBIC) and the American Chemical Society (ACS) ARC assessor for ARC Grant applications Referee for the journals: Journal of the American Chemical Society; Chemistry–A European Journal; Journal of Physical Chemistry B, Inorganic Chemistry; Organometallics; Dalton Transactions; European Journal of Inorganic Chemistry; Inorganic Chemistry Communications; Chemical Reviews Editorial Board Member for the International Journal of Inorganic Chemistry (IJIC) and for the Journal of Chemical Science (JChem).

SECTION 02 Invited Lectures, Conference and Media Presentations: Colbran, S. B, Biological and Bio-inspired Multielectron Reduction Catalysis, Invited Lecture,

Department of Inorganic & Nuclear Chemistry, Indian

Institute of Science (IIS), Bangalore, India, 16 Jan.

05 07

2012 Colbran, S. B, Biological and Bio-inspired Multielectron Reduction Catalysis, Invited Lecture,

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Chemical Physics Department, ChemiCentrum, Lund

University, Sweden, 6 Sept. 2012

Colbran, S. B, Transition Metal Chemistry of Multifunctional Organohydride Ligands, Session

21 23 25

Lecture, International Coordination Chemistry

Conference (ICCC) 40, Valencia, Spain, 11 Sept.

2012.

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Associate Professor Marcus Lawford Cole B.Sc (Hons) Ph.D Cardiff Cardiff University BSc (Hons I) (Medal) 1998, PhD 2001. Lecturer and Senior Lecturer, University of Adelaide (2004-7). Royal Society and ARC research fellowships at Monash University (2002-3). NSW Young Tall Poppy Science Award 2009. RACI Organometallic Chemistry Award in 2010. Elected Fellow of the RACI in 2012.

Current Research Activities:

Professional Activities:

Low oxidation state and hydrido complexes of the

Secretary of the Inorganic Division, Royal Australian

main group elements. Catalytic applications of N-heterocyclic carbenes. Low oxidation state lanthanide chemistry and its synthetic application.

Chemical Institute. Fellow of the Royal Australian Chemical Institute, member of the American Chemical Society. Organising committee member for the 27th International Conference on Organometallic

Selected Publications: Dunn, MD; Cole, ML; Harper JB: Effects of an ionic liquid solvent on the synthesis of gammabutyrolactones by conjugate addition using NHC organocatalysts, RSC Advances, 2012, 2, 10160-

Chemistry (Melbourne, 2016). Member of the Australasian discussion group on organometallic chemistry. Referee for A* journals of the ACS, RSC, Wiley-VCH and Elsevier publishing houses.

10162. hydride complexes of NHC coordinated gallium and

Invited Lectures, Conference and Media Presentations:

indium, Dalton Trans, 2012, 41, 946-952.

Ionic Liquid Effects on Catalytic Reactions: More

McKay, AI; Ball, GE; Cole, ML: Low valent and

Gyton, MR; Cole, ML; Harper JB: Ionic liquid effects

Than Just Carbene Formation? – Australian

on Mizoroki-Heck reactions: more than just carbene

Symposium on Ionic Liquids, May 2012, Monash

formation, Chem. Commun., 2011, 47, 9200-9202.

University, Victoria.

Alexander, SG; Cole, ML; Forsyth, CM: Tertiary Amine and N-Heterocyclic Carbene Coordinated Haloalanes - Synthesis, Structure and Application, Chem. Eur. J., 2009, 15, 9201-9214. Junk, PC; Cole, ML: Alkali metal bis(aryl) formamidinates – A study of coordinative versatility, Chem. Commun., 2007, 1579-1590 (feature article).

SECTION 02 Dr Gavin Leslie Edwards B.Sc, Ph. D Monash Born in 1960, Dr Edwards completed his PhD studies at Monash University with Dr (now Professor) Glen Deacon and Professor David St Clair Black. He then undertook postdoctoral

research at Imperial College, London, with Dr (now Professor) Willie Motherwell from 1987-

1989. Dr Edwards was appointed as a Lecturer at UNSW in 1990 and Senior Lecturer in

1999. He is currently the Director of Teaching in the School of Chemistry. In 2011 he also

took on the role of Associate Dean (Undergraduate Programs) in the Faculty of Science.

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Current Research Activities:

Professional Activities:

Synthesis of novel DNA binding agents: new

Director of Teaching

bisintercalating threading molecules, and

Member: School of Chemistry Executive

organometallic drugs

Member: Faculty of Science Education Committee

Member: Faculty of Science Standing Committee

Member: Faculty of Science International Committee

Member: School of Chemistry Executive

Member: Faculty of Engineering Education

Sulfones, sulfoxides and sulfoximines in organic synthesis Cyclometallated complexes as new catalysts

Selected Publications: Beeren, S.R., Dabb, S.L., Edwards, G., Smith, M.K., Willis, A.C., and Messerle, B.A., Improving Intramolecular Hydroamination Rh(I) and Ir(I) Catalysts Through Targeted Ligand Modification, New J. Chem., 2010, 34 1200-1208. Edwards, G.L., Sinclair, D.J. “Sequential cyclosulfonylation and alkylation as a versatile strategy for dihydropyran synthesis.” Synthesis, 2005, 3613-3619. Edwards, G.L., Black, D,St.C., Deacon, G.B., Wakelin, L.P.G. “In vitro and in vivo studies of neutral cyclometallated complexes against murine leukaemias.” Can. J. Chem. 2005, 83, 980-989. Edwards, G.L., Black, D,St.C., Deacon, G.B., Wakelin, L.P.G. “Effect of charge and surface area

Committee Member: UNSW Project 4-3-2-1 Admissions and Conversions Group Member: UNSW Enrolment and Admissions Management Committee

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Member: UNSW Early Intervention and Retention Reference Group

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Member: UNSW Student Safety and Wellbeing Committee

Member: Academic Domain – Business System

Owners Advisory Group

67 69

73 75

Member: Pre-University and Alternative Education Committee Member: Advisory Board of Organic Preparations and Procedures International.

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on the cytotoxicity of cationic metallointercalation

reagents.” Can. J. Chem. 2005, 83, 969-979.

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Professor Leslie D. Field Ph.D., D.Sc. USyd

Ph.D. 1979 University of Sydney; D.Sc. 1991 University of Sydney; Postdoctoral Fellow, University of Southern California, Los Angeles, California, USA 1979-1981; Research Fellow, Oxford University, UK, 1981-1982; 1982-2005 Lecturer/Senior Lecturer/Reader/Professor University of Sydney; Professor of Organic Chemistry at the University of Sydney 1990 to 2005 and Head of the School of Chemistry from 1997 to 2001; Associate Dean for Research the Faculty of Science, Chair of the University Research Committee, Deputy Chair of the Academic Board and Acting Pro-Vice-Chancellor (Research) at the University of Sydney. Vice-President & Deputy Vice-Chancellor (Research) at UNSW from April 2005.

Current Research Activities:

Professional Activities:

Organometallic chemistry of coordinated dinitrogen nitrogen fixation.

Fellow of the Australian Academy of Science Fellow of the Royal Australian Chemical Institute

C-H Bond activation and functionalisation

Member of the American Chemical Society

Organometallic chemistry of carbon dioxide

Member of the International Society for Magnetic Resonance

Applications of NMR spectroscopy in organic & organometallic chemistry Transition metal catalysis in organic synthesis Transition metal acetylides, organometallic polymers and new materials Metallocene chemistry

Selected Publications: Bott, G.; Field, L. D.; Sternhell, S., Steric Effects a Study of a Rationally Designed System. J. Am. Chem. Soc. 1980, 102 (17), 5618-5626. Baker, M. V.; Field, L. D., Reaction of sp2 C-H Bonds in Unactivated Alkenes with Bis(Diphosphine) Complexes of Iron. J. Am. Chem. Soc. 1986, 108 (23), 7433-7434. Baker, M. V.; Field, L. D., Reaction of Ethylene with a Coordinatively Unsaturated Iron Complex, Fe(depe)2 - sp2 C-H Bond Activation without Prior Formation of a p-Complex. J. Am. Chem. Soc. 1986, 108 (23), 7436-7438. Field, L. D.; Turnbull, A. J.; Turner, P., Acetylidebridged organometallic oligomers via the photochemical metathesis of methyl-iron(II) complexes. J. Am. Chem. Soc. 2002, 124 (14), 3692-3702. Field, L. D.; Li, H. L.; Dalgarno, S. J.; Turner, P., The first side-on bound metal complex of diazene, HN=NH. Chem. Commun. 2008, (14), 1680-1682.

Journal Reviewer: Organometallics, Inorganic Chemistry, Dalton Transactions, Journal of the American Chemical Society, Nature Chemistry, Journal of Organometallic Chemistry, Chemical Communications Australian Research Council: Ozreader Director and Chairman NewSouth Innovations Pty Ltd Director Australian Technology Park Innovations Pty Ltd Director Victor Chang Cardiac Research Institute Director Uniseed UITT Pty Ltd Director Uniseed Management Pty Ltd Director Spatial Information Systems Ltd (SISL) Alternate Director of the Environmental Biotechnology CRC National ICT Australia Ltd (NICTA) UNSW Member Representative Board Member ARC Centre for Functional Nanomaterials Advisory Board Member of the National Drug & Alcohol Research Centre (NDARC) Board of Management

SECTION 02 Scientia Professor John Justin Gooding B.Sc. (Hons) Melb., D.Phil. (Oxon), CChem, MRACI Graduate of Oxford University (D. Phil., 1994). Postdoctoral Fellow, University of Cambridge, (1994-1996). Vice-Chancellor’s Postdoctoral Research Fellow, UNSW (1997-1998). Lecturer, Flinders University of South Australia (1998). Appointed Lecturer at UNSW (1999), Senior Lecturer (2002), Associate Professor (2006), Professor (2006) Scientia Professor (2011). NSW Young Tall Poppy Science Prize (2004), Alexander von Humboldt Fellowship (2005), University of Canterbury Erskine Fellow (2007), Royal Australian Chemical Institute (RACI) Analytical Chemistry Division Lloyd Smythe Medal (2007), Vice-Chancellors Teaching Award for Postgraduate Supervision (2008), Eureka Prize for Scientific Research (2009), ARC Australian Professorial Fellow (20102014), RACI H.G. Smith Medal (2011), RACI Electrochemistry Division R.H. Stokes Medal (2012), Royal Society of Chemistry Australasian Lecturer (2012) Co-Director of the Australian Centre for NanoMedicine.

01 03 05 07 09 11 13 15 17 19 21 23 25 27

Current Research Activities: Immunosensors for detection of protein analytes (with a US based biosensing company) Understanding electron transfer through a new class of molecular wires (with Professor Michael PaddonRow, Chemistry UNSW). Porous silicon photonic crystals for biological imaging and disease diagnosis (with Professor Mike Gal and Dr Peter Reece, Physics UNSW and Dr. Katharina Gaus, Medicine UNSW) Modified surfaces for controlling surface interactions with cells for biomaterials applications (with Dr. Katharina Gaus, Medicine UNSW) Nanoparticle based biosensors labelling and detection in for medical diagnostics (with Professor Rose Amal, Chemical Engineering, UNSW). Silicon quantum dots for biolabelling (with the Australian Centre for NanoMedicine) Detection of microRNA (with Prof. Maria Kavallaris, Australian Centre for NanoMedicine). The three dimensional printing of cells (with Australian Centre for NanoMedicine).

Selected Publications: Gooding JJ, Wibowo R, Liu J, Yang W, Losic D, Orbons S, Mearns FJ, Shapter JG, Hibbert DB, Protein Electrochemistry using Aligned Carbon Nanotube Arrays, J. Am. Chem. Soc. 125, 9006-9007 (2003).

K.A. Kilian, L.M.H. Lai, A. Magenau, S. Cartland, T. Böcking, N. Di Girolamo, M. Gal, K. Gaus, J.J. Gooding, Smart Tissue Culture: In Situ Monitoring of Cellular Secretion With Nanostructured Photonic Crystals NanoLett. 9 2021-2025 (2009).

29 31 33 35 37 39

D.J. Williamson, D.M. Owen, J. Rossy, M. Wehrmann, A. Magenau, J.J. Gooding, K. Gaus, Pre-existing LAT clusters do not participate in early T cell signaling events, Nature Immunology 12 655-662 (2011).

P.K. Eggers, N. Darwish, M.N. Paddon-Row, J.J. Gooding, Surface-Bound Molecular Rulers for Probing the Electrical Double Layer, J. Am. Chem. Soc. 134 7539-7544 (2012).

L.M.H. Lai, I.Y. Goon, K. Chuah, M. Lim, F. Braet, R. Amal, J.J. Gooding, Biochemiresistor Sensor– A New Type of Biosensor Employing Magnetic Assembly of Gold Coated Magnetic Nanoparticles, Angew. Chem. Int. Ed. 51 6456-6459 (2012).

43 45 47 49

53 55 57 59 61 63 65 67 69 71

Professional Activities:

Co-Director of the Australian Centre for NanoMedicine

Leader, CSIRO Flagship Collaboration Fund Research Cluster of Sensing Systems for Monitoring Aquatic Environments

Fellow of the RACI and Past-Chair of the Electrochemistry Division of the RACI

Member of The International Society of Electrochemistry and Australian Regional Representative Associate Editor (Handling) of Australian Journal of Chemistry

83 85 87

91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Member of the editorial board of the journals Electrochemistry Communications, Electroanalysis, Sensors, Nanobiotechnology, Sensors and Actuators B, Sensor Letters, Journal of Nanoeducation, Analyst, Chemical Sciences, Biosensors Member of the University Professorial Promotions Committee, School Advisory Committee, PostGraduate Research Student Committee, Analytical Centre Solid State Advisory Group and Australian National Fabrication Facility UNSW node access committee. Referee for the journals Nature Materials, Nature Nanotechnology, Journal of the American Chemical Society, Analytical Chemistry, Langmuir, Journal of Physical Chemistry B., Electroanalysis, Electrochemistry Communications, Talanta, IEEE Transactions on Biomedical Engineering, Sensors, Australian Journal of Chemistry, Analytical and Bioanalytical Chemistry, Biosensors Bioelectronics, Nucleic Acids Research, The Analyst, Chemical Communications, Journal of Immunological Methods, Journal of Material Science. Referee for grant applications for the Refereed Grants for ARC, City University Research Grant Program, Hong Kong, A*star Singapore, NSERC, Canada. Consultant for AgaMatrix Inc. and Inventia Pty Ltd

Invited Lectures, Conference and Media Presentations: B. Guan, L.M.H. Lai, K. Chuah, I.Y. Goon, A. Magenau, M. Lim, P.J. Reece, N. Di Girolamo, K. Gaus, Rose Amal, J.J. Gooding, Nanoparticle Based Biosensors for Diagnostics and Personalised Medicine, MQ Biofocus Research Centre 2012 Conference, Stamford Grand North Ryde, 14 Dec (2012). Plenary J.J. Gooding, New sensing technologies with potential for nanotoxicology, International Workshop on the Risk Assessment of Manufactured Nanomaterials, University of South Australia, 8-9 October (2012). Invited Talk

J.J. Gooding, A.L. Gui, G.Z. Liu, A. Barfdokht, N.A. Darwish, S. Ciampi, C.C.A. Ng, Electrodes that resist protein fouling when used in biological fluids: Applications for biosensing, cell biology and implantable electrodes, 3rd International NanoMedicine Conference, Sydney, Australia 2-4 July (2012). Keynote presentation S. Ciampi, A. Ng, M. Choudhury, S.G. Parker, G. Le Saux, K. Gaus, J.J. Gooding, Making Silicon Water Friendly: An Approach To Producing Stable Oxide Free Silicon for Electrochemical Applications, 10th International Society of Electrochemistry Spring Meeting, Perth, Australia, 15-18 April (2012). Keynote Speaker J.J. Gooding, L.M.H. Lai, I.Y. Goon, K. Chuah, E. Murago, M. Lim, R. Amal, Dispersible Electrodes: Gold Coated Magnetic Nanoparticles for Electrochemical Sensing, 18th Australian Electrochemistry Symposium, Electrochemistry Division of the Royal Australian Chemical Institute, Curtin University, Perth 15 April 2012. R.H. Stokes Medal Award Lecture J.J. Gooding, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells, 27th Philippines Chemical Congress, Manila, Philippines, 11-13 April (2012) Opening Plenary Address J.J. Gooding, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells, Workshop on Biotechnological Advances for Defence Applications, Defence Scientific and Technology Organisation (DSTO), 18 March 2012, Invited Speaker J.J. Gooding, L.M.H. Lai, I.Y. Goon, K. Chuah, G. Liu, E. Murago, E. Luais, M. Lim, R. Amal, Nanostructured materials for novel biosensing applications, 14th Asia Pacific Confederation of Chemical Engineering Congress, APCChE 2012, Singapore, 21-24 February (2012). Invited Speaker J.J. Gooding, L.M.H. Lai, I.Y. Goon, K. Chuah, G. Liu, E. Murago, E. Luais, M. Lim, R. Amal, Nanostructured materials for novel biosensing applications, International Conference of Nanoscience and Nanotechnology 2012, Perth, Australia, 5-9 February (2012). Invited Speaker

SECTION 02 M. James, S. Ciampi, T. Darwish, T. Hanley, J. Gooding, Water, Water Everywhere... Nanoscale Condensation of Water on Self-Assembled Monolayers and Click- Functionalized Surfaces, International Conference of Nanoscience and Nanotechnology 2012, Perth, Australia, 5-29 February (2012). 78. Research School of Chemistry, Australian National University, Canberra, 30/11/12, Making Silicon Water Friendly for Electrochemical, Cell Biology and Molecular Electronic Applications School of Chemistry, The University of Tasmania, Hobart, 14/11/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells School of Chemistry, The University of New South Wales, Sydney, 1/11/12, Self-Assembled Monolayers: A History at UNSW that is more than just biosensors School of Chemistry, Monash University, Melbourne, 10/10/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells School of Chemistry, University of Auckland, Auckland, 24/9/12, Biosensors: Then Pathway to Portable Analytical Devices Environmental Analysis 73. Department of Chemistry, University of Waikato, Hamilton, 21/9/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells 72. Department of Chemistry, Massey University, Palmerston North, 19/9/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells Department of Chemistry, Victoria University, Wellington, 18/9/12, Why are biosensors not even more successful? Some of the issues, some of the solutions. 70. Department of Chemistry, The University of Canterbury, Christchurch, 17/9/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells 69. Department of Chemistry, The University of Otago, Dunedin, 14/9/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells

School of Chemistry and Biomolecular Sciences, The University of Western Australia, 5/9/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells School of Chemistry and Physics, The University of Adelaide, 3/9/12, Nanotechnology and biosensors: From detecting small molecules to monitoring the activity of whole cells RACI, NT branch, Charles Darwin University, Darwin, 12/6/12, Biosensors: The Pathway to Portable Analytical Devices Environmental Analysis

01 03 05 07 09 11 13 15 17

School of Chemistry, The University of New South Wales 8/5/12, Writing a Paper: Who’s Job is It?

School of Chemical and Biomolecular Engineering, National University of Singapore, 21/2/12, Biosensors: Then Pathway to Portable Analytical Devices Environmental Analysis

21 23

27 29 31 33

School of Chemistry, Deakin University 17/2/12, Some advantages of nanomaterials for biosensing. 62. School of Chemistry, Sydney University, 15/2/12, Why are biosensors not even more successful? Some of the issues, some of the solutions. Schools Talk: “Biosensors: What are they, who cares?” Marrara Christian College, Darwin, June 12th 2012.

35 37 39 41 43 45 47 49 51 53

Awards:

55 57

The Royal Society of Chemistry, Australasian Lecturer for 2012 The Royal Australian Chemical Institute, 2012 R.H. Stokes Medal for Electrochemistry

59 61 63 65 67 69 71 73 75 77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Ronald Stanley Haines B.Sc. (Hons 1, University Medal), Ph.D. UNSW Postdoctoral Research Associate with Prof. B.J. Orr, UNSW, 1982-1983; Senior Tutor, School of Chemistry, UNSW 1983-1989; Principal Tutor, School of Chemistry, UNSW 1989-1992; Lecturer in Physical Chemistry, UNSW 1992-present. First Year Laboratory Coordinator 2008 - present.

Current Research Activities:

Professional Activities:

Chemical education and educational technology

Member, School of Chemistry Honours Thesis Reading Committee

Applications of computers and computer networks to chemical problems including chemical kinetics, data acquisition

Selected Publications: Bogaard M.P., Haines R., Raman Intensities and Cartesian Polarizability Derivatives, Mol. Phys, 41(6), 1980, 1281-1289 Duval A.B., King D.A., Haines R., Isenor N.R., Orr B.J., Coherent Raman Spectroscopy of Glyoxal Vapour, Journal of Raman Spectroscopy, 17(2), 1986, 177-182 Haines R, Teaching Computer Concepts to Undergraduate Chemists, J. Chem. Educ., 1998, 75, 785-787 Haines R.S., Woo, D.T., Hudson, B.T., Mori, J.C., Ngan, E.S.M., Pak, W-Y Interdisciplinary Educational Collaborations: Chemistry and Computer Science, J. Chem. Educ., 2007, 84, 967-970 Haines, R.S., Wu, A.H.F., Lamb, R., Hua Zhang, Coffey, J., Huddle, T., Lafountaine, J.S., Lim, Zhi-Jun, White, E.A. and Tuong, N.T., Self-Cleaning Surfaces: A Senior Undergraduate Research Project, J. Chem. Educ. 2009, 365-367

School of Chemistry IT Coordinator. Member, School of Chemistry Teaching Committee Member, Faculty of Science IT Committee. Member, UNSW IT End-User Hardware Procurement Steering Committee

SECTION 02 Dr Jason Brian Harper B.Sc. Adel., B.Sc. (Hons), Ph.D. ANU Born 1974. Undergraduate work carried out at the University of Adelaide (B.Sc. 1995) and in The Faculties, Australian National University (B.Sc. (Hons) 1996). Shell Australia Postgraduate

Scholar, Research School of Chemistry, Australian National University (Ph.D. 2000). C.J. Martin

Postdoctoral Fellow, University Chemical Laboratory, Cambridge (2000-2002). Associate

Lecturer, The Open University in East Anglia (2001). Appointed to the School of Chemistry,

University of New South Wales as Lecturer in 2002 and Senior Lecturer in 2007. SSP at Boston

09 11

College (2009).

13 15 17 19 21

Current Research Activities: Application of physical organic chemistry to understanding organic processes, including: The development of an understanding of ionic liquids as novel reaction media, and their application. The examination of the chemical and physical properties N-heterocyclic carbenes, particularly those based on ionic liquid cations (in collaboration with Assoc. Prof. Marcus Cole, School of Chemistry, UNSW) The investigation of novel NMR spectroscopic methods for monitoring reaction kinetics (in collaboration with Dr James Hook, UNSW Analytical Centre).

Selected Publications: Yau, H. M.; Croft, A. K.; Harper, J. B.: “One-Pot Hammett Plots: A General Method for the Rapid Aquisition of Relative Rate Data”, Chemical Communications 2012, 48, 8937-8939. Yau, H. M.; Croft, A. K.; Harper, J. B.: “Investigating the origin of entropy-derived rate accelerations in ionic liquids”, Faraday Discussions 2012, 154, 365371. Gyton, M. R.; Cole, M. L.; Harper, J. B.: “Ionic liquid effects on Mizoroki-Heck reactions: More than just carbene complex formation”, Chemical Communications 2011, 47, 9200-9202. George, S. R. D.; Edwards, G. L.; Harper, J. B.: “The effect of ionic liquids on azide-alkyne cycloaddition reactions”, Organic and Biomolecular Chemistry 2010, 8, 5354-5358.

Jones, S. G.; Yau, H. M.; Davies, E.; Hook, J. M.; Youngs, T. G. A.; Harper, J. B.; Croft, A. K.: “Ionic liquids through the looking glass: theory mirrors experiment and provides further insight into aromatic substitution processes”, Physical Chemistry Chemical Physics 2010, 12, 1873-1878.

23 25 27 29 31 33 35

Professional Activities:

Director, Faculty of Science Talented Students Programme

Deputy Director of Teaching, School of Chemistry

43 45 47

Co-Chair and Bid Developer, Local Organising Committee, 23rd IUPAC Conference on Physical Organic Chemistry (Sydney 2016)

Treasurer, Southern Highlands Conference on Heterocyclic Chemistry

Member, Australian Chemistry Discipline Network

Member, Royal Australian Chemical Institute

Member, American Chemical Society (ACS)

51 53

57 59

65 67 69

Invited Lectures, Conference and Media Presentations:

71 73 75

Keynote lecture, 21st IUPAC Conference on Physical Organic Chemistry. Invited lecture, 5th Australasian Symposium on Ionic Liquids Invited lectures at Cardiff and Griffith Universities and the Universities of Bristol and Queensland.

77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Professor David Brynn Hibbert B.Sc., Ph.D. Lond. C.Chem FRSC FRACI Brynn Hibbert completed his degrees in chemistry at the University of London, King’s College (BSc 1972, PhD 1976). After a research assistantship at The City University, London, he became a lecturer in Physical Chemistry at Bedford College, University of London. In 1987 he was appointed to the Chair of Analytical Chemistry at UNSW. He served as Head of School from 1993 to 1996.

Current Research Activities:

Professional Activities:

Chemometrics and statistics in chemistry Metrology and quality assurance in chemistry Mass spectrometry and drug analysis Electrochemical sensors and biosensors, electronic nose technology

University Committees Member, e-research coordination group.

Membership of Committees

Education with an electronic laboratory notebook

Australian representative to the General Assembly of IUPAC, 2006 –

Selected Publications:

Secretary, IUPAC Analytical Chemistry Division Committee (V), 2008 – 2012

De Bièvre, P.; Dybkaer, R.; Fajgelj, A.; Hibbert, D. B., Metrological traceability of measurement results in chemistry: Concepts and implementation (IUPAC Technical report). Pure Appl. Chem. 2011, 83, 18731935. Ebrahimi, D.; Li, J. F.; Hibbert, D. B., Classification of weathered petroleum oils by multi-way analysis of gas chromatography-mass spectrometry data using PARAFAC2 parallel factor analysis. Journal of Chromatography A 2007, 1166, (1-2), 163-170. Hibbert DB (2007) Quality Assurance for the Analytical Chemistry Laboratory Oxford University Press, New York, pp310 ISBN 0195162137. Fleury, V., Kaufman, J.H. and Hibbert, D.B., A Mechanism of Morphology Transition in Ramiﬁed Growth, Nature 367, 435-438, (1994). Hibbert D Brynn, Bell Graham, A method of predicting the source of data sampled from an unknown source, Australian Patent 2006904660. Filed 28 August, 2006, PCT/AU/2007 001214.

Project leader, IUPAC project team for Terminology in Chemometrics IUPAC representative on the Joint Committee for Guides in Metrology, Working Group 1. (BIPM, Paris) Chair of Pure Reference Materials Review Committee, National Measurement Institute. Chair of Matrix Reference Materials Review Committee, National Measurement Institute. Australian representative to International Chemometrics Society. Member Chemical Testing Accreditation Advisory Committee, NATA (National Association of Testing Authorities) Member Reference Materials Accreditation Advisory Committee, NATA.

SECTION 02 Membership of learned societies Member Australian Academy of Forensic Science (Council, 2009 –) Royal Society of New South Wales: (Council, 2009–2011, Vice President 2011–) Fellow, Royal Australian Chemical Institute

Invited Lectures, Conference and Media Presentations: Plenary presentation “Science in Court” - South Western Association of Forensic Scientists, Scottsdale Arizona, November 2012.

01 03 05

Editorships

Workshop –“Bayesian Methods in Analytical Chemistry”, South Western Association of Forensic Scientists, Scottsdale Arizona, November 2012

International Advisory Board of Accreditation and Quality Assurance in the Analytical Laboratory (ACQUAL), Springer

Plenary presentation “Crooks, Cranks and Charlatans”, - The Australian Academy of Forensic Scientists, February 2012.

Fellow, Royal Society of Chemistry.

Book review editor, ACQUAL Australasian Editor, Sensors, MDPI, Basel.

07 09 11

15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59 61 63 65 67 69 71 73 75 77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Luke Hunter B. Ad.Sc (Hon), Ph.D, USyd Born in 1979, Dr Hunter completed his Undergraduate and Postgraduate work at The University of Sydney gaining his B. Ad.Sc (1999) and Ph. D (2004). He went on to Postdoctoral positions at The University of Melbourne (2005), The University of St Andrews (2005 – 2008), The University of NSW (2008 – 2009) and The University of Sydney (2009 – 2011). He was appointed Senior Lecturer at UNSW in 2011.

Current research Activities:

Professional Activities:

Natural product total synthesis

MRACI CCHEM

Fluorinated amino acids

Member, American Chemical Society

Antimicrobial cyclic peptides GABA receptor ligands for treatment of stroke RGD peptides for treatment of cancer

Selected Publications: Hunter, L.; Kirsch, P.; Slawin, A. M. Z.; O’Hagan, D.,

Invited Lectures, Conference and Media Presentations: ACS Spring Meeting, San Diego, USA: “Fluorinated amino acids: building blocks for the synthesis of shape-controlled bioactive peptides.”

“Synthesis and structure of stereoisomeric multi-

Departmental seminar, The University of Melbourne:

vicinal hexafluoroalkanes,” Angewandte Chemie

“Fluorinated amino acids: building blocks for the

International Edition 2009, 48, 5457.

synthesis of shape-controlled bioactive peptides.”

Hunter, L.; Kirsch, P.; Slawin, A. M. Z.; O’Hagan,

Departmental seminar, The University of Queensland:

D., “Synthesis and conformation of multi-vicinal

“Fluorinated amino acids: building blocks for the

fluoroalkane diastereoisomers,” Angewandte Chemie

synthesis of shape-controlled bioactive peptides.”

International Edition 2007, 46, 7887. Hunter, L.; Chung, J. H., “Total synthesis of unguisin A,” Journal of Organic Chemistry 2011, 76, 5502. Hunter, L.; Jolliffe, K. A.; Jordan, M. J. T.; Jensen,

Departmental seminar, CSIRO (Clayton): “Fluorinated amino acids: building blocks for the synthesis of shape-controlled bioactive peptides.” Contributed lecture, International Conference on

P.; Macquart, R. B., “Synthesis and conformational

Organic Synthesis, Melbourne: “Fluorinated amino

analysis of α,β-difluoro-γ-amino acid derivatives,”

acids: building blocks for the synthesis of shape-

Chemistry: A European Journal 2011, 17, 2340.

controlled bioactive peptides.”

Yamamoto, I.; Jordan, M. J. T.; Gavande, N.; Doddareddy, M. R.; Chebib, M.; Hunter, L. “The

Awards:

enantiomers of syn-2,3-difluoro-4-aminobutyric acid

ARC DECRA

elicit opposite responses at the GABAC receptor,” Chemical Communications 2012, 48, 829.

SECTION 02 Associate Professor Naresh Kumar M.Sc. Punj. Ph.D. W’gong., CChem, MRACI A/Prof Naresh Kumar completed his PhD in organic chemistry at Wollongong University in

1983, and after working as a Research Scientist at the School of Chemistry, University of NSW

was appointed a Lecturer in 2003. He moved through the ranks to become an Associate

Professor in chemistry in 2009.

07 09 11 13 15 17 19

Current Research Activities:

Professional Activities:

Design and synthesis of quorum-sensing inhibitors Development of synthetic methodologies for the preparation of biologically important natural products and their analogues Novel antimicrobial biomaterials Heterocyclic chemistry Calixarene chemistry

Selected Publications:

21 23 25

Internal:

Academic in charge: B Med Chem program

Member: School of Chemistry Research Management Committee Member: School of Chemistry Postgraduate Committee

31 33 35 37 39 41

Member: School of Chemistry Search Committee

Member: School of Chemistry Visiting Committee

45 47

Iskander G, Zhang R, Chan D, Black DStC, Alamgir M, Kumar N, An efficient synthesis of brominated 4-alkyl-2(5H)-furanones, Tetrahedron Letters, 2009, 50, 4613-4615. Cheah WC, Wood K, Black DStC, and Kumar N, Facile ring-opening of N-acylisatins for the development of novel peptidomimetics. Tetrahedron 2011, 67, 7603-7610. Devakaram R, Black DStC, Andrews KT, Fisher GM, Davis RA, Kumar N, Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives. Bioorganic & Medicinal Chemistry, 2011,19, 5199-5206. Ho K, Cole N, Chen R, Willcox MDP, Rice S, Kumar, N. Immobilisation of antibacterial dihydropyrrol-2ones onto functional polymer supports to prevent bacterial infections in vivo, Antimicrobial Agents and Chemotherapy, 2012, 56, 1138-1141. Eugene MH, Pasqueir E, Iskander G, Black DStC, and Kumar N, Synthesis of novel isoflavenepropranolol hybrids as anti-tumor agents, Bioorganic &. Medicinal Chemistry, 2013, 21,1652-1660.

External:

49 51

Member, Royal Australian Chemical Institute (RACI)

Member, American Chemical Society

Chair, RACI (NSW) Natural Products Chemistry Group 2013

Assessor for ARC Discovery and Linkage Projects

Assessor for ARC Future Fellowship applications

59 61

Reviewer for NHMRC Project Grant applications Research project evaluation for King Fahd University of Petroleum and Minerals, Saudi Arabia Reviewer for Academic Research Fund applications, Nanyang Technological University, Singapore

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MSc and PhD thesis examiner for national and international universities

Referee for Tetrahedron Letters, Tetrahedron, Current Medicinal Chemistry, Synlett, Synthesis, Australian Journal of Chemistry, Bioorganic and Medicinal Chemistry, Journal of Organic Chemistry, Chirality, Journal of Medicinal Chemistry, Biofouling, and Acta Biomaterialia

87 89 91 93 95 97 99

Invited Lectures, Conference and Media

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Presentations: Kumar N, Synthesis of novel biologically active scaffolds based on flavones and isoflavones, School of Chemistry, University of Wollongong 14 May 2012. Kumar N, Synthesis of novel biologically active scaffolds based on flavones and isoflavones, ICOS19/RACIOC24 19th International Conference on Organic Synthesis, Melbourne, 05 July 2012. Kumar N, Novel antimicrobial coatings based on antimicrobial peptides and quorum sensing inhibitors, Asian Network for Natural and Unnatural Materials II, Nanyang Technological University, Singapore, 03-05 October 2012. Kumar N, Novel antimicrobial coatings based on antimicrobial peptides and quorum sensing inhibitors, 1st International Conference on Emerging Advanced Nanomaterials, The University of Queensland, Brisbane, 22-25 October 2012.

Kumar N, Novel antimicrobial coatings, 3rd Biennial International Conference on Drug Discovery from Natural Products and Traditional Medicines (DDNPTM-2012), National Institute of Pharmaceutical Education and Research (NIPER), India, 22-24 November 2012.

Awards: UNSW Staff Award for Excellence in Community Outreach

SECTION 02 Associate Professor Shelli Renee McAlpine Ph. D. UCLA Born in 1969, A/Prof. McAlpine was awarded her PhD from The University of California, Los Angeles, in 1997. She then spent three years as a Postdoctoral Researcher at Harvard University before being appointed as an Assistant Professor at San Diego State University in

01 03

2000. Shelli was promoted to Associate Professor in 2006 and Professor in 2010. In 2011 Shelli

joined UNSW as an Associate Professor.

07 09 11 13 15 17 19 21 23

Current research Activities: Synthesis of Natural Products and their analogues Development of new antibiotics Investigating Hsp90 inhibitors as potential chemotherapeutics Mechanistic evaluation of natural products Creating delivery methods for our biologically active molecules

Selected Publications: Erinprit K. Singh, Deborah M. Ramsey, and Shelli R. McAlpine* Org. Lettv14, p1198-1201. 2012 Melinda R. Davis, Erinprit K. Singh, Hendra Wahyudi, Leslie D. Alexander, Joseph Kunicki, Lidia A. Nazarova, Kelly A. Fairweather, Andrew Giltrap, Katrina A. Jolliffe, and Shelli R. McAlpine* Tetrahedron, v68, p1029-1051, 2012 Veronica C Ardi, Leslie D. Alexander, Victoria Johnson, and Shelli R. McAlpine, ACS Chemical Biology v6, p1357, 2011 Leslie D. Alexander, James Partridge, David Agard, and Shelli R. McAlpine, Bioorganic and Med. Chem. Lett. v21, p7068-7071, 2011

Professional Activities: American Chemical Society: Member Executive comm. (Med Chem Division) Mar 2011-Mar 2014 Section Editor for Oncology for Annual Reports in Medicinal Chemistry Nov 2009- current Advisory board member for “Current Topics in Medicinal ChemistrySept 2009- current

American Chemical Society: Member Executive comm. (Organic Division) Mar 2009-Mar 2012

25 27 29

Invited Lectures, Conference and Media Presentations:

31 33 35

Macrocyclic peptides: the perfect tools to explore protein function; H3-D Symposium, Cape Town, South Africa – plenary speaker, October

37 39 41 43

Hsp90 inhibitors that modulate the immunophilins;

Swedish society for biochemistry, biophysics, and

molecular biology, Sweden – Keynote speaker, September Hsp90 inhibitors that modulate the immunophilins; University of Western Australia (Biology department), July Macrocyclic peptides: confirmation that dictates biological activity: University of Western Australia (Chemistry department), July Macrocyclic peptides: the perfect tools to explore protein function; University of Auckland NZ, July Macrocyclic peptides: the perfect tools to explore protein function; University of Tasmania, May Macrocyclic peptides: the perfect tools to explore

49 51 53 55 57 59 61 63 65 67 69 71 73 75 77 79 81 83

protein function; Howard Florey Institute, May

Macrocyclic peptides: the perfect tools to explore

protein function; University of Wollongong, May

89 91

Macrocyclic peptides: the perfect tools to explore

protein function; University of Melbourne, April

95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Professor Barbara Anne Messerle Ph. D. Syd Ph.D. University of Sydney 1987. Postdoctoral Fellow ETH Zürich, Switzerland 1987-1989, Gritton Research Fellow, University of Sydney 1990-1991; ARC Queen Elizabeth II Fellow 19921997, and ARC Senior Research Fellow 1997-1998, at the University of Sydney. Appointed to UNSW as ARC Senior Research Fellow 1999-2002, Senior Lecturer 2002-2003, Associate Professor 2004-2007 and Professor 2008. Head of School 2007 - current.

Current Research Activities: Enhancing the economic viability and the energy efficiency of chemical transformations is of fundamental importance in the chemicals industry. Organometallic catalysts are an increasingly important means of providing new and more efficient routes for chemical processes. Our research projects involve the design and synthesis of metal catalysts for: The formation of C-X bonds in heterocycles (X=N,O,S) The synthesis of amines via the hydrosilation and hydrogenation of imines. Our projects also involve developing Novel bimetallic catalysts for enhancing catalyst efficiency

Torstein Fjermestad, Joanne H. H. Ho, Stuart A. Macgregor, Barbara A. Messerle, and Deniz Tuna, Computational Study of the Mechanism of Cyclic Acetal Formation via the Iridium(I)-Catalyzed Double Hydroalkoxylation of 4-Pentyn-1-ol with Methanol Organometallics, 2011, 30(3), 618-626. ERA ranking A* Michael J. Page, Jörg Wagler, and Barbara A. Messerle “Pyrazolyl-N-Heterocyclic Carbene Complexes of Rhodium as Hydrogenation Catalysts: The influence of Ligand Steric Bulk on Catalyst Activity”, Dalton Trans, 2009, 7029-7038 Serin Dabb, Barbara Messerle,* Gottfried Otting, Jörg Wagler and Anthony Willis “Ruthenium Complexes of Substituted Hydrazine - Novel Solution and Solid State Binding Modes”, Chem Eur J., 14(32), 10058-10065, 2008

Professional Activities:

New approaches to catalysed multiple step reactions for the synthesis of amines and spiroketals

Head of School

Novel approaches to the immobilization of transition metal catalysts on surfaces

Member of the Excellence in Research Australia (ERA) panel, 2012

New methods using parallel synthesis for developing catalysts for multistep processes

Chair of National NMR Steering committee (ANZMAGnet) for developing a National NMR Facility

Selected Publications:

Chair, University Committee on Management of Hazardous Materials and Dangerous Goods

Carol Hua, Khuong Q. Vuong, Mohan Bhadbhade and Barbara A. Messerle New Rhodium(I) and Iridium(I) Complexes Containing Mixed Pyrazolyl-1,2,3-Triazolyl Ligands as Catalysts for Hydroamination, Organometallics, 2012, 31 (5),1790–1800 Joanne Hui Hui Ho, Sandra Choy, Stuart Macgregor, Barbara A. Messerle “Cooperativity in Bimetallic Dihydroalkoxylation Catalysts built on Aromatic Scaffolds: Significant Rate Enhancements with a Rigid Anthracene Scaffold”, Organometallics, 2011, 30(21), 5978–5984.

Member, Selection committee for HOS, School of Mathematics and Statistics Member, Selection committee for HOS, Member, University Committee on IT Business domain strategy on HR systems Member, University of Sydney Committee for the award of a DSc Member, Committee for University Prizes Process Review

SECTION 02 Member, Judging Committee, UNSW Science Faculty Photo Competition Chair, Appointment Committees, Lecturer Chemistry x2 and one General staff member, Chemistry, UNSW Patron, AdminNet, UNSW Mentor for the Academic Women in Leadership, Early Career Researcher UNSW programs Reviewer, International Granting Agencies: American Chemical Society Petroleum research fund, USA Member, Asia Pacific NMR 2013 Scientific committee Presentations: North Sydney Girls High, Careers Day, June, “Careers in Chemistry Journal Reviewer 2012: Journal of the American Chemical Society, Dalton, Chemical Communications, Organometallics, Inorganic Chemistry, Dalton, Angewandte

Invited Lectures, Conference and Media Presentations: M. Timerbulatova, S. W. S. Choy, M. J. Page, S. A. Macgregor and B. A. Messerle, “Cooperativity in Bimetallic Catalysts – The Relationship Between Structure and Catalyst Efficiency” 25th International Conference on Organometallic Chemistry (ICOMC25), Lisbon, Portugal, 2nd-7th September 2012.

01 03 05 07 09 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59 61 63 65 67 69 71 73 75 77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Associate Professor Jonathan Charles Morris B.Sc UWA, Ph.D ANU A/Prof Morris obtained his B.Sc. (Hons) degree from the University of Western Australia. He completed his Ph.D. degree at the Australian National University in 1994. After a postdoctoral appointment at the University of Texas at Austin (1994-1996), he joined the faculty at the University of Canterbury, New Zealand. In 2004, he moved to the University of Adelaide. In late 2009, he was appointed as Associate Professor of Medicinal Chemistry at the University of New South Wales.

Current Research Activities: Total synthesis of biologically active natural products Design of inhibitors of kinases that regulate alternative splicing [with Prof D. Bates (Nottingham) and Prof S. Knapp (Oxford)] Applications of the Diels-Alder reaction to the synthesis of biologically active molecules

Echalier, A.; Bettayeb, K.; Ferandin, Y.; Lozach, O.; Clement, M.; Valette, A.; Liger, F.; Marquet, B.; Morris, J.C.; Endicott, J.; Joseph, B.; Meijer, L., Synthesis, protein kinase inhibitory activity and cytotoxicity of 3-(pyrimidin-4-yl)-7-azaindoles (meriolins). CDK2/cyclin A/meriolin and CDK2/cyclin A/variolin B crystal structures, J. Med. Chem. 2008, 51, 737.

Design of phosphatase activators (with Dr Anthony Don, Lowy Cancer Centre and Dr Nikki Verrills, University of Newcastle)

Postgraduate Coordinator, School of Chemistry.

Medicinal chemistry (projects with Prof Peter White, BABS and the Centre of Vascular Research).

Program Director, Bachelor of Medicinal Chemistry (until June)

Selected Publications:

Member, School Advisory Committee, School of Chemistry, UNSW

Anderson, R. J.; Hill, J. B.; Morris, J. C., Concise Total Syntheses of Variolin B and Deoxyvariolin B, J. Org. Chem., 2005, 70, 6204. Bungard, C.J.; Morris, J.C., Total Synthesis of the 7,3’-Linked Naphthylisoquinoline Alkaloid Ancistrocladidine, J. Org. Chem., 2006, 71, 7354. Bettayeb, K.; Tirado, O. M.; Marionneau-Lambot, S.; Ferandin, Y.; Lozach, O.; Morris, J.C.; Mateo-Lozano, S.; Drückes, P.; Schächtele, C.; Kubbutat, M.; Liger, F.; Marquet, B.; Joseph, B.; Echalier, A.; Endicott, J.; Notario, V.; Meijer, L., Meriolins, a new class of cell death-inducing, cyclin-dependent kinase inhibitors with enhanced selectivity for CDK9, Cancer Research, 2007, 67, 8325-8334

Professional Activities:

Member, Research Committee, School of Chemistry, UNSW Member, Faculty of Science Higher Degree Committee Faculty of Science representative, UNSW PhD Review Implementation Committee Member, First Year Curriculum Review committee. Chair, RACI NSW Branch Organic Division One Day Symposium. Member, Royal Australian Chemical Institute and American Chemical Society. Referee for ACS, RSC, Wiley and Elsevier Journals.

SECTION 02 Dr Nicholas Kenneth Roberts B.Sc.(Hons) Ph.D. University of Western Australia Born in 1952 Dr Roberts gained his BSc (Hons), 1973 and PhD, 1979, with Dr S. Bruce Wild,

University of Western Australia. Post-doctoral research followed with Prof. Bryce Bosnich at

Lash-Miller Laboratories, University of Toronto, Canada, between 1979 and 1981. Research

Fellow, Australian National University with Professor Martin A. Bennett 1981 to 84. Appointed as

a lecturer in the School of Chemistry, UNSW in 1984 and senior lecturer in 2005. Dr. Roberts is the current coordinator of first year classes.

09 11 13 15 17 19

Current Research Activities:

Professional Activities:

Synthesis and Reactions of Volatile Zinc Carbamates for Chemical Vapour Deposition.

Director of First Year Chemistry

Member: Teaching Committee

Synthesis and Reactions of Volatile Aluminium Carbamates for Chemical Vapour Deposition.

Member of the Royal Australian Chemical Society

29 31 33 35

Selected Publications:

Petrella AJ, Deng H, Roberts NK, and Lamb RN, Single-source chemical vapor deposition growth of ZnO thin films using Zn4O(CO2NEt2)6, Chemistry of Materials 14 (10): 4339-4342 Oct 2002.

Heterobimetallic calix[4]arene complexes: Interconversion of dimeric (Ca, Sr or Ba)/TiIV complexes with a monomeric K/TiIV complex. Petrella, Antonella J.; Roberts, Nicholas K.; Raston, Colin L.; Craig, Donald C.; Thornton-Pett, Mark; Lamb, Robert N. European Journal of Inorganic Chemistry (2003), (23), 4153-4158.

A heterobimetallic K2Ti2 complex incorporating two calix[5]arenes: A diverse array of metal-ligand interplay. Petrella, Antonella J.; Roberts, Nicholas K.; Craig, Donald C.; Raston, Colin L.; Lamb, Robert N., Chemical Communications (2003), (14), 1728-1729.

Dialkylcarbamato magnesium cluster complexes: precursors to the single-source chemical vapour deposition of high quality MgO thin films. Hill MR, Jones AW, Russell JJ, Roberts NK, Lamb RN, Journal of Materials Chemistry, 14 (21): 3198-3202, 2004

Towards new precursors for ZnO thin films by single source CVD: the X-ray structures and precursor properties of zinc ketoacidoximates. Hill, MR; Jones, AW; Russell, JJ; Roberts, NK; Lamb, RN, Inorganica Chimica Acta (2005) 358(1): 201-206.

41 43 45 47

51 53 55 57 59 61 63

67 69 71 73 75

79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Neeraj Sharma B.Sc. Ph.D, University Sydney Dr Sharma completed his Undergraduate (2006) and Postgraduate (2010) work at the University of Sydney. He then became a postdoctoral researcher at the Bragg Institute, Australian Nuclear Science and Technology Organisation (ANSTO). Dr. Sharma was appointed as a Lecturer at UNSW in conjunction with an Australian Institute of Nuclear Science and Engineering (AINSE) Research Fellowship.

Current Research Activities:

W. Miiller, M. Avdeev, Q. Zhou, B. J. Kennedy, N.

Structural investigations of new materials using synchrotron X-ray and neutron scattering

Sharma, R. Kutteh, G. J. Kearley, S. Schmid, K.

In situ studies of materials functioning in real-life devices

magnetoelastic effect at the opening of a spin-gap

Development of new ionic conductors

Society, 134, 3265-3270 (2012)

S. Knight, P. E. R. Blanchard, C. D. Ling, Giant in Ba3BiIr2O9, Journal of the American Chemical

Selected Publications:

Professional Activities:

N. Sharma, G. Du, Z. Guo, J. Wang, Z. Wang, V.

Seminar Coordinator, Chair of the UNSW Chemical Society

K. Peterson, Direct evidence of concurrent solidsolution and two-phase reactions and the nonequilibrium structural evolution of LiFePO4, Journal of the American Chemical Society, 134, 7867-7873 (2012)

Secretary Materials Division, RACI Member of the International Society of Electrochemistry, Royal Australian Chemical Institute, Society of Crystallographers in Australian and New Zealand, Australian X-Ray Analytical Association

R. J. Gummow, N. Sharma, V. K. Peterson, Y. He, Crystal chemistry of the Pmnb polymorph of Li2MnSiO4, Journal of Solid State Chemistry 188, 3237, (2012) cover N. Sharma, V. K. Peterson, In situ neutron diffraction experiments on lithium-ion batteries, Journal of Solid State Electrochemistry, 16, 1849-1856 (2012) D. Li, Y. D. Huang, N. Sharma, Z. X. Chen, D. Z. Jia, Z. P. Guo, Enhanced electrochemical properties of LiFePO4 by Mo-substitution and graphitic carboncoating via a facile and fast microwave-assisted solid-state reaction, Physical Chemistry Chemical Physics, 14, 3634-3639 (2012)

Invited lectures, conference & media presentations: Investigating Materials for Lithium-ion Batteries using Neutron Diffraction, 10th Spring Meeting of the International Society of Electrochemistry, Perth, Australia Using neutrons and X-rays to study lithium-ion batteries, Meeting of the Chemistry Education group of the Royal Australian Chemical Institute, Sydney

Awards: RACI Nyholm Lecturship

SECTION 02 Associate Professor John Arron Stride B.Sc. (Hons), Ph.D., University of E. Anglia, UK. Dr. Stride obtained his B.Sc.(Hons.) in Chemistry in 1991 and a Ph.D. in 1996 from the

University of East Anglia, UK. He then held Post-Doctoral Fellowships at the Hahn-Meitner

Insitute, Germany, (1995-1998) and at the Laboratoire Léon Brillouin, France, (1998-2000)

before taking on the role of instrument scientist in the Time-of-Flight Group at the Institute Laue-

Langevin, France, (2000-2005). He moved to UNSW in 2005.

09 11 13 15 17 19

Current Research Activities:

Professional Activities:

Molecular and low dimensional magnetism

Chair: Research Committee, Research Director

Molecular dynamics and solid state structures

Member: Faculty of Science Research Management Committee, School Research Committee, School Advisory Committee, School Executive Committee.

21 23

Inorganic functional materials Neutron scattering Nano-structured materials & grapheme

Selected Publications: A flexible copper based microporous metalorganic framework displaying selective adsorption of hydrogen over nitrogen. M.A. Nadeem, A.W. Thornton, M.R. Hill and J.A. Stride, Dalton Trans., 2011, 40, 3398. Gram-scale production of graphene based on solvothermal synthesis and sonication. M. Choucair, P. Thordarson and J.A. Stride, Nat. Nanotechnol., 2009, 4, 30. The central atom size effect on the structure of Group XIV tetratolyls. M.C.C. Ng, D.J. Craig, J.B. Harper, L. van-Eijck and J.A. Stride, Chemistry, Eur.

Member: Instrument Advisory Teams for Pelican, Lyrebird and Emu, Bragg Institute, ANSTO

25 27 29 31 33 35 37 39

Invited lectures, conference & media presentations:

41 43 45

Magnetic Materials: Complexity and porosity, ItalyAustralia Bilateral Meeting on Magnetic Materials, October 2012.

47 49 51

Graphene and nanostructured carbons as templates, scaffolds or supports, ICAEN2012 Brisbane, October 2012.

Graphene and nanostructured carbons as templates, scaffolds or supports, ANNUM2012, Singapore, October 2012.

Functional Materials: Sustainable futures, The University of Queensland, Brisbane, April 2012.

55 57 59

63 65 67 69 71 73

J., 2009, 15, 6569. Structure and dynamics of a discotic liquid crystalline charge transfer complex. O. Kruglova,

75 77 79 81

E. Mendes, Z. Yildirim, M. Wübbenhorst, F.M.

Mulder, J.A. Stride, S.J. Picken and G.J. Kearley,

ChemPhysChem., 2007, 8, 1338.

Symmetry and Topology Determine the MoV-CN-MnII Exchange Interactions in High Spin Molecules, E. Ruiz, G. Rajaraman, S. Alvarez, B. Gillon, J. Stride, R. Clérac, J. Larionova and S. Decurtins, Angew. Chem., Int. Ed, 2005, 44, 2711.

89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Pall Thordarson B.Sc. (Iceland), Ph.D. USyd, CChem, MRACI A/Prof. Pall Thordarson obtained his BSc. in Chemistry from the University of Iceland in 1996 and a PhD in Organic Chemistry from The University of Sydney, Australia in 2001. After a Marie Curie Post-doc in the Netherlands he returned to the University of Sydney as a research fellow in 2003. He was appointed at UNSW in 2007 and he is now an ARC Future Fellow and Associate Professor in the School of Chemistry at UNSW He received the Australian NSW Young Tall Poppy Science Award in 2008, the International SPP/JPP Young Investigator Award for 2010 and the 2012 Le Fèvre Memorial Prize from the Australian Academy of Science for outstanding basic research in Chemistry by a Scientist under the age of 40.

Current Research Activities:

Professional Activities:

Light-activation in bioelectronics

Editorial board member – Commissioning Editor, the Australian Journal of Chemistry.

Self-assembled gels for biomedical applications and electroactive displays Application of microscopy in chemistry

Advisory Board Member, Biomedical Imaging Facility, Mark Wainwright Analytical Centre, UNSW.

Non-linear interactions in supramolecular chemistry

Member, Faculty of Science, Special International Strategy Committee, Faculty of Science, UNSW.

Selected Publications:

Chair, Safety Committee, the School of Chemistry, UNSW.

Pall Thordarson, Determining Association Constants from Titration Experiments in Supramolecular Chemistry, Chem. Soc. Rev., 2011, 40, 1305-1323. David Hvasanov, Jörg Wiedenmann, Filip Braet and Pall Thordarson, Induced Polymersome Formation from a Diblock PS-b-PAA Polymer via Encapsulation of Positively Charged Proteins and Peptides, Chem. Commun., 2011, 47, 6314-6316. Joshua R. Peterson, Trevor A. Smith and Pall Thordarson, Synthesis, characterization and room temperature photo-induced electron transfer in biologically active bis(terpyridine)ruthenium(II)cytochrome c bioconjugates and the effects of solvents on the bioconjugation of cytochrome c, Org. Biomol. Chem., 2010, 8, 151-162. Katie W. K. Tong, Sabrina Dehn, James E. A. Webb, Kio Nakamura, Filip Braet and Pall Thordarson, Pyromellitamide Gelators: Exponential Rate of Aggregation, Hierarchical Assembly and their Viscoelastic Response to Anions, Langmuir, 2009, 25, 8586-8592. James E. A. Webb, Maxwell J. Crossley, Peter Turner and Pall Thordarson, Pyromellitamide Aggregates and Their Response to Anion Stimuli, J. Am. Chem. Soc., 2007, 129, 7155-7162.

Membership of the Royal Australian Chemical Institute, The American Chemical Society, The Icelandic Chemical Society, Society of Porphyrins and Phthalocyanines (SPP), The Australian Microscopy and Microanalysis Society and the Marie Curie Fellowship Association.

Invited Lectures, Conference and Media Presentations: The role of electrostatic interactions in forming selfassembled gels and functional polymersomes in water, 7th International Conference on Macrocyclic and Supramolecular Chemistry (ICMSC-7), Otago University, Dunedin, New Zealand, 29th Jan – 2nd Feb 2012 Self-assembly in water: From autocatalytic gels to photosynthesis-respiration hybrid mimics, 19th IUPAC International Conference on Organic Synthesis (ICOS19) & 24th Royal Australian Chemical Institute (RACI) Organic Conference (RACIOC-24), Melbourne, Victoria, 1-6th July 2012 A light-driven protein bioconjugate proton pump in a polymersome – what molecular machines can teach us about protein delivery, 4th International Nanomedicine Conference 2012, Coogee, Sydney, 2-4th July 2012 Bioactive peptides and their release from self-assembled gels, Drug Delivery Australia 2012, Melbourne, Victoria, 26-27th November 2012.

SECTION 02 Dr Chuan Zhao

B.Sc. Ph.D NWU

Dr Zhao received his PhD in 2002 with an excellence award from Northwest University. He then completed 4 years of postdoctoral research at the University of Oldenburg, Germany. In 2006, he moved to Monash University as a senior research fellow. He joined UNSW in Oct 2010, and

is currently a Senior Lecturer. He also holds an ARC Australian Research Fellowship.

03 05 07 09 11 13 15 17 19 21

Current Research Activities:

Professional Activities:

Ionic liquid electrochemistry and applications for energy.

Chair of 4th Asian Pacific Conference on Ionic Liquids/ 6th Australian Syposium on Ionic Liquids

Electrocatalysts for clean energy.

Organizing committee member for 18th Australian Electrochemistry Conference (18AEC) / 10th International Society of Electrochemistry (ISE) Spring Meeting

Member Chartered Chemist of Royal Australian Chemistry Institute (RACI).

Member of American Chemical Society (ACS).

23 25

Scanning electrochemical microscopy Biosensors and bionics.

Selected Publications: C. Zhao, A. M. Bond, X. Lu, Determination of water in room temperature ionic liquids by cathodic stripping voltammetry at a gold electrode, Anal. Chem. 2012,

84 (6), 2784–2791 C. Zhao, D. R. MacFarlane and A. M. Bond,

Executive committee member, treasurer of Electrochemistry Division RACI Chair of UNSW Chemical Society.

nanowires and crystalline thin films of silvertetacyanoquinodimethane. J. Am. Chem. Soc. 2009, 131, 16195–16205 C. Zhao, A. M. Bond, Photoinduced oxidation of water to oxygen in ionic liquids BMIMBF4 as a counter reaction for fabrication of exceptionally long semiconducting polymeric AgTCNQ nanowires. J. Am. Chem. Soc. 2009, 131, 4279-4287 C. Zhao, I. Witte and G. Wittstock, Switching on cell adhesion with microelectrodes. Angew. Chem. Int. Ed., 2006, 45, 5469-5471.. C. Zhao and G. Wittstock, An SECM detection scheme with improved sensitivity and lateral resolution: detection of galactosidase activity with signal amplification by glucose dehydrogenase. Angew. Chem. Int. Ed., 2004, 43, 4170-4172.

33 35 37 39

47 49 51 53 55

Member of International Electrochemistry Society

Modified thermodynamics in ionic liquids for controlled electrocrystallization of nanocubes,

57 59

Invited Lectures, Conference and Media Presentations:

61 63 65

3rd Asia Pacific Conference on Ionic Liquids and Green Process, “Electrochemical aspects of water in ionic liquids” Beijing, China, 16- 19 Sept. 2012

67 69 71

5th Australasian Symposium on Ionic Liquids, “Water in ionic liquids: electrochemical concerns “ Melbourne, Australia, 3- 4 May. 2012.

10th Spring Meeting of the International Society of Electrochemistry, “Electrochemical aspects of water in ionic liquids” Perth, Australia, 15- 18 April. 2012

Faculty of Life Science, Xi’an Jiaotong University, “Nanoelectrochemical techniques and their applications in bionics and clean energy” Xi’an, Oct 2012

School of Chemistry and Chemical Engineering, Shaanxi Nornal University, “Electrochemistry of ionic liquids and its implications in clean energy”, Xi’an, Oct 2012

75 77 79

83 85

89 91 93

97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

RESEARCH Overview 2012 2012 saw the continued evolution of the School of Chemistry at UNSW, bringing new staff on-board and extending the high standards set over previous years. 2012 also saw the second round of the government’s Excellence in Research for Australia (ERA), with UNSW consolidating its position with an overall top grade of ‘5’ in Chemical Sciences and ‘5’s in both Analytical and Macromolecular Chemistries. Whilst rankings alone do not paint a full picture, this audit of research strengths is yet another example of the progressive stance of the School over recent years. It is therefore perhaps no surprise that the research of several of our staff and students were recognised with a number of national and international awards and accolades; Scientia Professor Justin Gooding was named as the Royal Society of Chemistry, Australasian Lecturer for 2012 and was awarded the Royal Australian Chemical Institute R.H. Stokes Medal for Electrochemistry for 2012. Stephen Parker (supervisor Scientia Professor Gooding) was awarded a poster prize at the 10th Spring Meeting of the International Society of Electrochemistry, Perth, Australia. David Hvasanov (supervisor: Dr Pall Thordarson) won a poster prize at the 2012 International Symposium on Macrocyclic and Supramolecular Chemistry, ISMSC-7, Dunedin, New Zealand. Xunyu Lu (supervisor: Dr Chuan Zhao) won the RACI Bloom-Gutmann Prize, which is awarded to the best student presentation at the Australasian Electrochemistry Conference, Perth. In addition to these notable examples, a number of students also were recipients of local and regional awards for presentations at grass root meetings - well done to all of you. In a highly competitive environment, particularly in relation to international students, the research student enrolments in 2012 were maintained at around 80 over the year. However this simple oversight is blind to the increased number of graduating HDR students – the increased intake over the last 3-4 years was reflected in an increased number of completing students, highlighting the efficiency of the School in moving HDRs through to completion.

SECTION 03 0101

year that saw the School set new records. We foresee

0303

this growth continuing due to the firm foundations upon

0505

which research in the School now stands.

0707 0909

And so another year’s reporting of the research

1111

successes of the School passes – a task made far more

1313 1515

easy by the wonderful achievements of all of our staff

1717

and students that are evident in the outcomes, but more

1919

importantly the clear direction that the School is taking

2121

in its research focus. The School of Chemistry at UNSW

2323 2525

is in good shape and like a good wine is aging well. The

2727

We also saw the ranks of academics boosted with the

School when looked at through metrics is simply a sum

2929

arrival of Dr. Neeraj Sharma late in 2012, recruited as

of its parts; however I sense that with the rejuvenation

3131

an AISNE Fellow. Neeraj comes to us from the Bragg

of the staff profile over recent years it has within it a

3333

Institute, ANSTO and prior to that he completed his

research culture that is far greater than simply the sum

PhD at the University of Sydney. He has a very strong

of dollars, papers or citations, promising positive futures

3939

research focus on battery and energy related materials

for all on-board. As Director of Research, I would like to

4141

and his research makes use of a range of diffraction

take this opportunity to thank everyone who has played

4343

techniques – from lab-based X-rays through to synchrotron

a role in shaping 2012, a year not without adversity. At

and neutron techniques. We welcome Neeraj and wish

times an individual makes progress in leaps and bounds,

4949

him every success in his career at UNSW.

at other times seemingly falteringly; collectively however

5151

that makes a journey and as such the School’s progress

5353

along the bumpy road of research is gaining pace...

5555

Research income and outcomes also saw significant gains in 2012, with the award of new ARC Discovery

3535 3737

4545 4747

5757 5959

Projects (Dr Jason Harper; Associate Professor Steve

ASSOCIATE PROFESSOR JOHN STRIDE

6161

Colbran, Dr Graham Ball & Professor Les Field;

Director of Research

6363

Professor Barbara Messerle and Associate Professor

6565

Pall Thordarson); an ARC DECRA to Dr Leigh Aldous, an

6767

ARC Future Fellowship to Dr Pall Thordarson, Dr Neeraj

6969 7171

Sharma’s AINSE Fellowship and a NHMRC grant to

7373

Associate Professor Shelli McAlpine; new funding to

7575

the collective tune of $3.3M. More importantly these

7777

outcomes mean that more of our staff now hold external

7979

grants, spreading the gains across the School. Staff

8181 8383

were also successful in securing funding from a more

8585

diverse range of sources including international and

8787

industry related schemes. The year-on-year increases

8989

in funding and staffing over the last 3-4 years are

9191 9393

now being realised in significant growth of research

9595

publications. 2012 produced 147 peer-reviewed articles

9797

published, the majority of which were in high-ranking journals; this represents a 12% increase over 2011. In all measures of research metrics, 2012 was a remarkable

9999 101 101 103 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Research Highlights Dr Luke Hunter Medicinal Chemistry Cluster Research in the Hunter group focuses on the design and synthesis of functional molecules. We have a particular interest in using organofluorine chemistry to optimise moleculesâ&#x20AC;&#x2122; properties: selectively incorporating fluorine atoms into molecules can be valuable in terms of controlling the molecular conformation, increasing the molecular stability, or tweaking moleculesâ&#x20AC;&#x2122; electronic properties. We are exploring all of these applications, with the primary motivation being the development of biologically active molecules. Our research is interdisciplinary in nature, and we collaborate extensively to analyse the properties of the molecules that we create.

Modulators of the central nervous system: Molecules that can selectively bind to targets in the central nervous system (CNS) have potential value as treatments for conditions such as depression, insomnia and stroke. To that end, we are developing fluorinated analogues of several natural CNS-active molecules, in order to increase their potency and selectivity. For example, we have created fluorinated analogues of the neurotransmitter GABA (gamma-aminobutyric acid),2,3 and we have shown that these fluorinated analogues exhibit shape-dependent GABA receptor selectivity.4 In another example, we have created fluorinated analogues of a plant-derived flavonol molecule, thereby modifying its GABA receptor activity from agonism to an antagonism.

Antimicrobial cyclic peptides: We are investigating cyclic peptide natural products as leads for the discovery of novel antimicrobials. The cyclic heptapeptide unguisin A has been reported to possess antibacterial activity, and the cyclic octapeptide pohlianin C has been reported to possess antimalarial activity. Importantly, both of these cyclic peptides are rather flexible molecules, and so we are exploiting fluorine chemistry to create conformationally-restricted analogues with the aim of increasing the antimicrobial potency.5

SECTION 03 Blocking the growth of solid tumours: Integrins are cell-surface receptors that mediate a variety of processes related to cell adhesion: for example, αVβ3 integrin is involved in angiogenesis,

and is therefore a target for the treatment of solid

tumors. Many different integrin receptors recognise

the same tripeptide sequence, RGD (arginine-glycine-

aspartate), but selectivity is determined by the ligand’s

09 11

3D conformation. To exploit this, we are creating

αVβ3-selective integrin ligands by synthesising shape-

controlled fluorinated RGD analogues.6 Our fluorinated

ligands are currently being investigated in integrin-

19 21

binding assays and angiogenesis assays, with the aim

of developing a drug that can block the blood supply to

solid tumours.

27 29 31

New synthetic methods:

Modern synthetic chemists have an obligation to

minimise energy consumption and waste. One way

37 39

to achieve this is to develop more efficient catalysts,

and within this area organocatalysts in particular have

received much recent attention. In the Hunter group,

we are investigating fluorinated amino acids (eg.

47 49

4-fluoroproline) as next-generation organocatalysts that

have improved conformational rigidity and lead to higher

optical selectivity than their non-fluorinated counterparts.

55 57 59

Selected publications 1. Hunter L., Beilstein J. Org. Chem. 2010, 6, doi: 10.3762/bjoc.6.38

61 63 65 67

2. Hunter L., Jolliffe K. A., Jordan M. J. T., Jensen P.,

Macquart R. B., Chem. Eur. J. 2011, 17, 2340

71 73

3. Wang Z., Hunter L., J. Fluorine Chem. 2012, 143, 143 4. Yamamoto I., Jordan M. J. T., Gavande N., Doddareddy M. R., Chebib M., Hunter L., Chem. Commun. 2012, 48, 829 5. Hunter L., Chung J. H. J. Org. Chem. 2011, 76, 5502

75 77 79 81 83 85 87

6. Hunter L., Butler S., Ludbrook S.B., Org. Biomol. Chem. 2012, 10, 8911

89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Neeraj Sharma Catalysis and Energy Cluster I joined the School of Chemistry UNSW in late 2012 after a postdoctoral research position at the Bragg Institute, Australian Nuclear Science and Technology Organisation (ANSTO). My research interests are in solid state and materials chemistry, where I investigate the crystal structures of compounds and manipulate them to optimise their physical properties. Arguably the key to my work is structural analysis using diffraction methods and my group specialises in in situ structural characterisation, i.e., structural characterisation whilst undergoing some chemical process. These processes may include formation studies (e.g. characterising the structural changes occurring during synthesis and determining optimal synthetic conditions) and ion extraction/insertion from compounds. Below I highlight some of my research and methodology.

Synthesis and characterisation of energyrelated materials

this energy only a few times, limiting its applicability in

Fundamentally, my research is based on using a

the structure collapses (Figure 1) when too much lithium

variety of synthetic techniques to make new materials,

is removed (during charge); we are now investigating

or modify existing materials so that they can be used

ways to avoid this structural collapse to yield more

as components in energy-related devices. Structural

powerful batteries.

characterisation of the synthesized materials is undertaken using the Rietveld method with both

rechargeable batteries. The major reason for this is that

In situ neutron and synchrotron X-ray diffraction studies of lithium-ion batteries

neutron and X-ray diffraction data. Characterisation of the physical properties of the materials includes

Lithium-ion batteries are found in the majority of portable

fundamental investigations of the magnetisation and

applications available today, such as mobile electronic

conductivity, but also more applied studies in which,

devices and power tools. However there is a need to

for example, an entire battery is constructed and

improve the amount of energy stored, safety and rates

the properties of the materials are studied within the

for charging of these batteries if they are to play an even

functioning device. An example of the link between the

larger role in society, e.g., providing an alternative to

crystal structure and properties is demonstrated by our

combustion engines for automotive applications and

recent work on a battery cathode material that has the

energy storage for renewable energy generation. My

potential to double the amount of energy stored in a

research group uses in situ techniques to probe how

lithium-ion battery. However, this electrode can deliver

the crystal structure of the components within lithium-

Figure 1. A fit of the structural model (top right) to neutron powder diffraction data (left) of a cathode material with potentially twice the energy density of currently-available commercial cathodes. The structure of the completely delithiated form of the cathode (bottom right), which is unfortunately unstable.

SECTION 03 ion batteries, namely the electrodes and electrolyte (if

Outlook

crystalline), evolve during charge-discharge cycling. In

My research aspirations are not only limited to

so doing, we build a detailed picture of the evolution of

batteries, we are also exploring fuel cells and

lithium-ion battery components as they actually function

hydrogen storage materials. Effectively, we explore

or work.

materials for better devices by understanding and

The image below shows the time-resolved changes in

manipulating the atomic-scale arrangements (crystal

05 07

both the anode and cathode Bragg reflections as the

structure) of the materials within these devices.

battery is charged and discharged at slower and faster

rates (Figure 2). Faster rates of discharge may occur

when a laptop is used at a higher brightness setting on

15 17

the screen requiring more energy, while slower rates are

found when a dimmer screen setting is used. Recently,

our work has tracked how lithium-ions move out of the

cathode and insert into the anode during charge and

25 27

the reverse during discharge â&#x20AC;&#x201C; effectively tracking the

atomic level battery function (Figure 3). This information

provides unique insights on the structure-function

relationship from which we can develop new materials

35 37

and a rationale for improvements.

39 41 43 45 47 49 51 53 55

Figure 2. Time-resolved in situ neutron powder diffraction patterns of a commercial cylindrical battery (right) represented in a 2D plot (selected region) with Bragg reflections of the cathode and anode indicated. Two current rates are employed and these are also labelled.

57 59 61 63 65 67 69 71 73 75 77 79 81

Figure 3. A custom made battery for in situ neutron diffraction experiments (left), a cathode Bragg reflection evolving during charge/discharge (middle) and the derived crystal structures from Rietveld analysis showing the lithium evolution (shading on the green spheres, right).

83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

School Postgraduate Seminars As part of the Schoolâ&#x20AC;&#x2122;s monitoring and mentoring system, postgraduate students present seminars at various stages of their candidature. The students giving these presentations present their latest research findings and provide the School with the opportunity to give feedback and advice. A panel of academic staff assesses each presentation, and the student is given feedback. As detailed below, there was a wide range of topics presented. In 2012, the seminars were held Tuesday lunchtimes and attended by the majority of the School. As in the past, the standard of the presentations was particularly impressive. March Stephen George

Polycyclic Aromatic Hydrocarbons: Synthesis and effects of non-planarity on reactivity

April Wei Jiang

Measuring and Controlling the Cluster State of Gold Nanoparticles in Simulated Biological Systems

Jiabin Gao

Synthesis and crystal engineering of bicyclo[3.3.0]octane derivatives

Venty Suryanti

The Chemistry of N-acylisatins

Yeng Ying Lee

Developing Ruthenium-Based Redox Labels for Electrochemical Biosensors

May Scott Jamieson

Unconventional growth: The formation of a family of organogels

Murat Bingul

Synthesis of novel heterocyclic compounds that enhance the anti-cancer effects of SAHA

Moinul Choudhury

Development of Light-Addressable Electrode Arrays

Ethan Howe

Bio-Inspired Supramolecular Architecture Towards Switchable Ion-Pair Receptors and Catalytic Molecular Cages

Xin Chen

Modification of indium tin oxide for biosensor application

Giulia Mancano

Ir(I)/Rh(I) complexes for catalysing the synthesis of amines

Zhiyong Wang

Synthesis of fluorinated cyclic RGD peptides

Joshua Ginges

Simplified Blocked Electrochemical Sensor Technology

Aravind Ramachandran

Modified Electrodes to Probe Extracellular Electron Transfer in Bacteria

Amirul Islam

Identifying novel antibacterial agents from natural product libraries

Alex Weremfo

Effectiveness of Roughened Platinum Microelectrodes in Neural Stimulation

June Dimple Rananaware

Target-specific approach for elucidation, selection and synthesis of anti-cancer drugs

Marcin Mielczarek

Design, synthesis and antimicrobial activity of novel small molecule RNA polymerase - transcription initiation factor Ď&#x192;70 interaction inhibitors

Worawan Tantisantisom

Synthesis of Sanguinamide B derivatives

Christopher Gardner

Synthesis and Characterization of Retinoid Enhancers for Anti-Cancer Therapies

August Warren Truong

Interactions of Self-Assembling Gels with Living Systems

Alex McSkimming

Transition metal complexes with ligands containing an organo-hydride domain

Alasdair McKay

Hydride Complexes of the Heavy Group 13 Metals

Thanh Le Matthew Gyton

Studies towards the development of novel antimicrobials Ring Expanded Chiral Carbenes and Low Valent Scandium Chemistry

Hamish Toop

Development of Synthetic Protocols for Application in the Syntheses of Biologically Interesting Molecules

Elizabeth Murago

Au@Fe3O4 nano-electrodes: Their electro-analytical performance as 'dispersible electrodes' and their use as sensors

SECTION 03 01 03 05 07 09 11 13

September

Xiaoyu (Jet) Cheng

Silicon quantum dots: fabrication, surface engineering and bioapplications

Dominic Francis

Towards Functional Fluorous Surfactants

Andrey Tregubov

Rh (I) complexes anchored on carbon supports - recyclable catalysts

Mark Gatus

Homo and Heterobimetallic Complexes For Tandem One-Pot Reactions

October

Bradley Butler

The effect of ionic liquids on reactions at phosphorus centres

Xunyu (Rain) Lu

Advanced Electrolytes and Catalysts for Efficient Water Oxidation Reactions

Stephen Parker

Towards Single-Cell Isolation Using Electrochemically-Switchable Surfaces

Michelle Dunn

Solvent effects on the acidity of heterocyclic carbon acids - correlations with organocatalytic activity

Kyloon Chuah

Towards single-molecule detection using nanoparticle-based nanopore biosensor

Hendra Wahyudi

Development of Macrocyclic peptides into Lead structures

Roya Tavallaie

Towards the biomedical applications of gold coated magnetic nanoparticles: Detection of serum circulating MicroRNAs as cancer markers

Seong Jong Kim

Exploring Macrocycles as potential anticancer drug leads

Bakul Gupta

Porous silicon photonic crystals for in vivo detection of protease activity

Ying Zhu

Patterning of Self-assembled Monolayers on Porous Silicon Biosensor: Toward Single Cell Monitoring

45 47 49

November

Ekaterina Nam

Surface-bound Light-activated Redox Enzyme Cascades

Sunhwa Lee

Approach to Biologically Active Compounds

Veronica Tecchio

Design of inhibitors for kinases that regulate alternative splicing

Swahnnya De Almeida

Development of a Circulating MicroRNA Biosensor for the Detection and Monitoring of Lung Cancer

Iqbal Ahmed

Conformational Fine-Tuning of Cyclic Peptides

Nripendra Biswas

Novel Small Molecules for the Modulation of Bacterial Signaling Pathways

Toby Mills

Analysis of micro-organism derived compounds for drug discovery

Abbas Barfidokht

Distance-Dependent Electron Transfer at Passivated Electrodes Decorated by Gold Nanoparticles

Asim Khan

Oxygen reduction reaction in ionic liquids

Mokarrom Hossain

Lignin Processing in Ionic Liquid: Electrochemical approaches towards Dissolution and Depolymerisation

Raju Cheerlavancha

Synthesis of alpha, beta, gamma-trifluoro- delta-amino acids

Lachlan Carter

Nanoparticle-mediated electrochemical gating: application to electroanalysis

Sandra Choy

Understanding Cooperative Catalysis with Bimetallic Rhodium(I) Complexes

Xun Lu

Super-resolution Fluorescence microscopy for Surface Characterisation

61 63 65

71 73

79 81

91 93

99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

School Seminars – Invited Speakers January KTH Royal Institute of Technology, Sweden

Nanotribology in the Cross Hairs, with a short digression into Vibrational Sum Frequency Spectroscopy of interfaces

A/Prof Joohoon Kim

Kyung Hee University, Korea

Development of Chip-based Analytical Devices for Their Applications to Chemo/Bioanalysis

Prof Jan van Esch

Delft University of Technology, Netherlands

Dynamic surfactants, polymers, and networks: in control of soft matter properties by dynamic covalent and dissipative self-assembly

Prof Kelly Chibale

Cape Town University, South Africa

Medicinal chemistry of antimalarial agents: integration of synthetic chemistry and preclinical pharmacology with drug metabolism and pharmacokinetic studies

Ian Dance

UNSW

Nitrogenase reduces N2 to NH3 and CO to hydrocarbons. What chemistry is used?

A/Prof Shuhei Furukawa

Kyoto University, Japan

Crystal Interface Engineering of Porous Coordination Polymers

A/Prof Spencer Williams

Melbourne University

Sweet medicine: Molecular studies of the roles of carbohydrates in disease and well-being

Dr Yun Hau Ng

ARC Centre of Excellence for Functional Nanomaterials

Development of semiconductor photoanodes for photoelectrochemical cells and water splitting

Dr Christopher Richardson

University of Wollongong

Playing tag with metal-Organic Frameworks: A tale of two Ligands

Dr Ashok Nanjundan

Institute for Nanoscience and Cryogenics, France

New developments in the functionalization chemistry of carbon based nanostructures: Synthesis, characterization and properties

Prof. Guoxiu Wang

University of Technology, Sydney

Electrochemical Energy to Power a Sustainable Future

A/Prof. Lianzhou Wang

The University of Queensland

Designing layered metal oxide semiconductors for photocataltyic and electrochemical energy conversion

Prof. Dale Boger

Scripps, USA

Redesign of Vancomycin for Resistant Organisms

Griffith University

Fabrication of Nanostructured Materials: New Approaches and Control Growth Mechanisms

Dr Justin Hodgkiss

Victoria University of Wellington

Molecular semiconductor aggregates: from photophysical dynamics to peptide-driven structures

Prof Peter Junk

Monash University

New metal based syntheses in rare earth chemistry

Prof Maria Forsyth

Deakin University

Novel Electro–materials and Interphases: from Energy to Sustainable Infrastructure

A/Prof Louis Rendina

University of Sydney

New Frontiers in the Therapeutic Application of Boron and Gadolinium

Université de Sherbrooke, Quebec, Canada

Half a Life Time of Making Chiral Quaternary Carbons

Prof Mark Rutland February

March

April

Prof. Huijun Zhao May

July Prof Claude Spino

SECTION 03 August Dr Jun Chen

University of Wollongong

NanoCarbon Composite Materials for Energy Application

A/Prof Nathan Gianneschi

University of California, San Diego

Enzymes, peptides, and nucleic acids for programming nanoparticle morphology and the nanoscale properties of materials

Dr Bun Chan

University of Sydney

What Can Computers Do For Chemists

CSIRO

Towards the next generation of lithium batteries: enabling the cycling of lithium metal electrodes using ionic liquid electrolytes

University of Melbourne

Dissecting the Insect Detoxification Machinery with Twin Ion Metabolite Extraction (TIME) Mass Spectrometry

01 03 05 07

Dr Anand Bhatt

Dr William Alex Donald Dr Malcolm McLeod A/Prof Mark Coster

09 11 13 15 17

Gone to the dogs: how organic chemistry can help in the fight against doping in sport

The Australian National University

Griffith University

Molecular Probes for Pancreatic Cancer: Synthesis and Evaluation of Natural Product Inspired AntiAusterity Agents

25 27 29

September

A/Prof. Richard Tilley

Victoria University of Wellington, New Zealand

A/Prof Marc in het Panhuis

University of Wollongong

Prof Phil Baran

Scripps, USA

Synthesis and Applications of Nanoparticles

33 35

Hydrogel composite materials

37 39

Howard Lecture: Studies in Natural Product Synthesis Part 2

41 43 45

Dr Wallace Wong

University of Melbourne

Organic Solar Cells â&#x20AC;&#x201C; From Material Design to Printed Devices

49 51

October Prof Max Crossley

University of Sydney

Functionalisation of the porphyrin periphery

55 57

Dr Aditya Rawal

UNSW

Solid-State NMR: Materials and Molecular Structures

59 61 63

A/Prof Chialiang Zhang

Chang Gung University, Taiwan

Graphene-based Nanocomposite Materials for Energy and Biosensor Applications

65 67 69

November

Dr David Lupton

Monash University

Discoveries in Catalysis using Nucleophilic N-heterocyclic carbenes

CSIRO

Biological applications of fluorinated and boronated amino acids, peptides and peptide mimics

73 75 77

Dr Peter Duggan

79 81 83

A/Prof Dusan Losic

The University of Adelaide

Self-ordered nanopore and nanotube arrays for emerging applications

87 89

December Prof Dan Li

Monash University

Graphene + water = A new class of functional soft materials?

91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

SECTION 04 01 03

TEACHING AND LEARNING

05 07 09 11 13 15 17 19 21

Overview

One initiative funded from the bequest of the late Theo

Howard was an undergraduate visiting lectureship,

Providing first class teaching means a School cannot

and the first of these was held in 2012. The aim of the

afford to rest on its laurels and for this reason a revised

lectureship is for outstanding academics from other

first year syllabus was rolled out in 2012. As mentioned

institutions to visit UNSW for a short period (typically 4

in last year’s report, Dr Pall Thordarson chaired the

to 6 weeks) and provide some advanced undergraduate

review committee and he also oversaw the introduction

lectures in our “Topics in Contemporary Chemistry”

of the new syllabus. The formal distinction between

courses (where both third year and Honours students

“Essentials of Chemistry” and “Higher Chemistry” at first

can take the Topics), along with a research seminar.

year was long overdue and the introduction of some

Our first Howard undergraduate lecturer was Associate

more advanced material into the higher-level courses

Professor Richard Tilley from the Victoria University of

was appreciated by students (and staff!). The syllabus

Wellington (New Zealand). As an expert in the synthesis

review also provided the opportunity to induct a couple

of quantum dots and the use of techniques such as

of our newer staff members into first year teaching and

transmission electron microscopy, Richard was an ideal

Dr Palli Thordarson and A/Prof. Shelli McAlpine both

inaugural lecturer to present a nanomaterials-themed

made excellent debuts.

Topic. By all reports the students loved his lectures and

he has set a very high standard.

One fascinating and encouraging trend is the increasing

47 49

57 59

popularity of the Higher Chemistry first year courses

DR GAVIN L. EDWARDS

compared with the regular versions. From 2006 to 2012

Director of Teaching

the enrolments in Higher Chemistry 1A have skyrocketed

71 73

from the low 200’s to almost 500 students. While not

all students progress to Higher Chemistry 1B, we have

seen enrolments in the 1B course increase from 104 in

2006 to almost 300. At the same time enrolments in the

81 83

regular level courses (the “Essentials” level) have held

their own so we have seen a dramatic increase in level

I enrolments. This has resulted in an increase in higher

year enrolments: while this is in part due to students

in the new Bachelor of Medicinal Chemistry program moving into higher years, the BMedChem program is not the sole contributor.

93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Chuan Zhao with his research group.

Dr Luke Hunter with his research group.

SECTION 04 Honours Program

of Business have been rationalised in line with the

The term ‘Honours Program’ in the School of Chemistry

working with the University on further restructuring. In

covers several UNSW undergraduate Programs. Our

2012 UNSW undertook a review of its postgraduate

Honours cohort includes students enrolled in the Bachelor

coursework program model due to changes in AQF

of Science majoring in Chemistry, the Bachelor of

requirements. This has resulted in the development of a

Advanced Science majoring in Chemistry, and the Bachelor

new policy and procedure for Postgraduate Programs,

of Science in Nanotechnology.

which have impacted on the CALM courses. It is

proposed to offer only the Graduate Certificate and

In the first two ‘chemistry’ focused degrees, students undertake their entire fourth year in the School of Chemistry. This comprises a research project in collaboration with a member of the academic staff and contemporary chemistry courses delivered by formal lectures.

recommendations, and the internal review team is

01 03

Masters programs (to be renamed ‘Master of Chemical

Analysis and Laboratory Analysis’), but retain the

Graduate Diploma as an exit qualification. The changes

will be made during 2013.

21 23 25

The BSc Nanotechnology students undertake a research project that represents just over 80% of their final year. This is carried out in the School of Chemistry, as per the BSc Chemistry majors, and is supplemented by a number of undergraduate courses taught by the Schools of Chemistry,

Postgraduate Research

29 31

Postgraduate research (HDR) student enrolments

continue to grow, with 21 new HDR students enrolled

35 37

over both the sessions. In 2012, the School had 80

PhD, 4 MSc and 3 MPhil students actively enrolled.

In 2012, 15 students completed Honours through the Bachelor

Concurrent with this healthy growth, we have seen a

of Science and Advanced Science BSc Programs, with a

significant increase in completions of HDR degrees,

further three beginning Honours in July 2012. Ten students

with 14 PhD students submitting their theses in 2012.

completed their Bachelor of Science in Nanotechnology with

The School also had its first MPhil completion in 2012.

research projects in the School of Chemistry.

The quality of our students and their research was

recognised with a number of externally awarded prizes

for oral presentations at conferences.

Physics and Materials Science and Engineering.

Postgraduate Programs and Courses

47 49

59 61 63

Chemical Analysis and Laboratory Management

Asia Pacific Institute of Nuclear Science Short Courses

The numbers in all programs reached record numbers

The APINS short course continued successfully in July

in 2010 and have stabilised in 2012, with the Masters in

and November this year.

65 67 69 71

Science and Technology being the most popular of the courses. Numbers of international students have fluctuated, but local students from industry and recent graduates seeking a postgraduate qualification have contributed to the cohort. Most courses had enrolments around 20 students. It will be recalled that a major review was undertaken in 2011 with external experts from industry and academia. The review showed strong support for the programs and offered fifteen recommendations for improvement of the course. In 2012 the courses from the Australian School

The ‘Radiation Safety for X-Ray Equipment Personnel’

course aims to equip participants who are seeking

81 83

a license for the installation and servicing of X-ray

equipment with the knowledge necessary to recognise

potential hazards and to minimise exposure to external

ionising radiation. This course is an accredited training

91 93

course across Australia. The course presenters in 2012 were Dr Ron Rosen, Mr Colin Hockings and Mr Paul Cardew.

95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Outreach Activities The School of Chemistry outreach program was established in 2007 to foster stronger links with high schools and to stimulate an interest in science and technology in high school students. The School has organised a variety of programs and events in the past year to meet these goals.

School visits

Presentations at the Science Teachers’ Association of NSW (STANSW) Chemistry Workshops The School has continued to maintain strong links with the Science Teachers’ Association of NSW (STANSW). As part of STANSW’s teacher professional day, the School was invited to deliver a presentation on the HSC topic “Chemical Equilbria & Haber Process” at the STANSW Chemistry Day, as well as a talk on “Misconceptions in Chemistry” at the STANSW Annual

The School of Chemistry has once again been very

conference. The teachers really appreciated the

active in hosting visits from various high schools near

opportunity to gain a deeper understanding of the topic

and far in the past year. The schools hosted this year

area and links to new resources. The feedback from the

included Sydney Technical High School and Mount Sinai

teachers from the events was extremely positive.

College, in addition to regular attendees. The School of Chemistry has put together a

The following is a quote from Margaret Watts, President, Science Teachers’ Association of NSW:

comprehensive set of hands-on chemistry experiments for Year 10 students. The students took an active part in experiments, which involved fatty acid analysis of an oil sample, preparation of biodiesel and demonstrations on magic bottles, luminol reactions, and atomic absorption and infrared spectroscopy. The students thoroughly enjoyed the visit and the feedback from the high schools has been extremely positive. In particular the students enjoyed working in real Chemistry laboratories and undertaking advanced experiments that exposed them to new equipment and modern chemical techniques.

UNSW visits to Schools The School of Chemistry took the outreach activities to the local schools participating in Newington College Science Festival and giving chemistry demonstrations at St George Girls High School. Our demonstrations on ocean acidification (dry ice + water), forensics (luminol reaction), biofuel, redox reactions (“magic bottle” colour changes) and equilibrium (“clock” reactions) were quite popular and well attended. The School also did a presentation on Haber Process for Year 12 students at the St Aloysius College.

“Colleagues, I have now been given an account of the STANSW Chemistry day. It is obvious that you have all contributed to a most successful day with engaging and instructive presentations that enhanced the professional learning of teachers of Chemistry in NSW. The children of NSW will be the beneficiaries of the efforts that you put into the preparation and delivery of your presentations. I also wish to acknowledge the hard work that went on behind the scenes during the organisation of this day. Please accept my sincere thanks and hearty congratulations for a job well done in the service of science education through STANSW”.

SECTION 04 Visits to Country High Schools and the UNSW Chemistry Video Competition Two new programs, Visits to Country High Schools

had our visitors captivated. Overall the event was a resounding success and there was a lot of interest in Chemistry, Medicinal Chemistry and Nanotechnology.

(organized by Dr Luke Hunter) and the UNSW Chemistry

Hosting work experience students

success. These programs are funded by the generous

This year the School of Chemistry hosted 10 work

Howard bequest.

experience students who worked under the supervision

Video Competition, initiated this year were a great

Participation in the outreach programs organised by the Faculty of Science Science Parent/Student night

of postgraduate mentors, experiencing first-hand the

joys and thrills of research.

13 15 17

Degrees Awarded

of queries from year 11 and year 12 students keen to do science at the university level.

21 23

The School actively participated in this highly successful event organised by the Faculty and answered a number

Master of Science and Technology in Chemical Analysis and Laboratory Management (MSc Tech, Program 8708)

25 27 29 31 33

Eiman M ALAHMADI

Nura Gili Winter Schools Program

Khadijah ALAITHAN

A number of indigenous high school students took part

Rasha Ali ALASMARI

in the Science stream of this program, taking a tour of

Karma ALBALAWI

Mashael Tayih S ALHARBI

the chemistry building and undertaking some chemistry experiments. The students thoroughly enjoyed the day and found it highly educating. Science High School Information Day

Turki Hamid H ALHIJI

47 49

Hajar Hmoud ALHWAITI

Amenh Hmod ALJOHANI

53 55

Eman Abdullah ALJOHANI

to entice potential Year 12 students to UNSW by

Mohammad HABL ALMATIN

Anhar Ali ALMUBASHIR

showcasing the range of different Science experiences available through lectures and hands-on activities in

Jameel Ali M ALQAHTA

laboratories. The School oranised hands-on chemistry

Sooaad Awdah ALSHAHRANI

activities for the visiting students and presented a short

Khadijah ALSHANQITI

Fatemah ALSHEHRI

The objectives of the UNSW Science Info Day is

talk on options for studying chemistry at UNSW. UNSW Open Day 2012 The School actively participated in the UNSW Open Day 2012, with academics stationed at the Scientia Advisory

Raed Dakhel ALSOBHI

75 77

Anna Nina CHUA

Brent HARRISON

81 83

Huiping HUANG

Juo-Chieh LEE

Yuvixza LIZARME SALAS

and Expanding Science” were delivered, and seminars on “Medicinal Chemistry” and “Nanotechnology”

Zhouyue LV

attracted significant interest. Academics and an army of

Thi Nguyet Thu NGUYEN

postgraduate students ambushed passing high school

Kylie OLUFSON

Centre to answer questions regarding the chemistry programs. Two presentations on “Chemistry – A Diverse

97 99

students at the chemistry marquee, which hosted a

101

variety of new and old favourite demonstrations which

103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Doctor of Philosophy (Ph. D, Program 1870) Candidate

Research Area

Supervisor

Renxun CHEN

Novel antimicrobial biomaterials based on cationic peptides

A/Prof. Naresh Kumar

Muthukumar CHOCKALINGAM

Development of cell based biosensor with dual detection using electrochemical impedance spectroscopy and optical fluorescence microscopy

Scientia Prof. Justin Gooding

Milena CZYZ

Investigations into the synthesis and properties of atropisomeric N-heterocyclic carbenes

A/Prof. Jonathan Morris

Chandramathi Sherman DURAI

Design and synthesis of DNA-binding agents using dynamic combinatorial chemistry

Prof. Margaret Harding

Lei GUI

Stable and low impedance anti-fouling coating formed from the reductive adsorption of aryl diazonium salts on electrode surfaces

Scientia Prof. Justin Gooding

Belinda HUFF

The development of pyrrolopyrimidines as kinase inhibitors

A/Prof. Jonathan Morris

Hakan KANDEMIR

Synthesis of novel BIS-indole systems

Prof. David Black

Sook Mei KHOR

Exploring the scope of an electrochemical immunosensor for the direct detection of small molecules in complex matrices

Scientia Prof. Justin Gooding

Samuel KUTTY

Novel nitric oxide donors as antimicrobial agents

A/Prof. Naresh Kumar

Santosh RAJPUT

Synthesis of novel heterocyclic analogues of isoflavones

A/Prof. Naresh Kumar

Ibhraim SENGUL

Synthesis of new heterocycle-linked bisindole systems

Prof. David Black

Hon Man YAU

A systematic approach to understanding organic reactivity in ionic liquids: changes in cybotacticity-induced solvent heterogeneity as an important determinant In reaction outcomes of substitution processes

Dr Jason Harper

Ruonan ZHANG

Synthesis of novel antimicrobial agents

A/Prof. Naresh Kumar

Alex Mason (BSc. Honours Nanotechnology), Dr. Pall Thordarson (Supervisor), Dr. David Hvasanov (PhD Chemistry), Lev Lewis BSc. Honours Nanotechnology), Alistair Laos (BSc. Honours Science/Arts)

Dr Renxun Chen and PhD graduate Samuel Kutty (Supervisor A/Prof Naresh Kumar)

A/Prof. Jonathan Morris (Supervisor), A/Prof. Marcus Cole (Supervisor), PhD graduate Milena Czyz and her proud parents.

SECTION 04 Postgraduate Research Completions The following students have submitted their thesis and will graduate in 2013 01

Master of Science by Research (Program MSc 2910 & MPhil Program 2475)

03 05

Candidate

Research Area

Supervisor

Joana Da Rocha

The development of pyrrolopyrimidine libraries

A/Prof Jonathan Morris

William Rouesnel

Silver nanocubes for surface nanostructure assembly

Scienta Prof. Justin Gooding

07 09 11 13 15 17 19 21

Doctor of Philosophy (Ph. D, Program 1870)

23 25

Research Area

Supervisor

Synthesis of novel Indole-based Macrocycles

Prof Naresh Kumar, Prof. David Black

Eleanor Eiffe

The synthesis of novel, biologically active isoflavone analogues

Prof Naresh Kumar, Prof. David Black

Jiabin Gao

Crystal engineering of bicyclo[3.3.0]octane derivatives

Emeritus Prof. Roger Bishop

Ryan Gilbert-Wilson

The use of sterically bulky phosphine ligands in iron and ruthenium dinitrogen chemistry

Professor Les Field

Kitty Ka Kit Ho

The development of novel antimicrobial coatings based on dihydropyrrolones

Prof Naresh Kumar, Prof. David Black

Camille Holt

An integrated synthetic and NMR spectroscopic study of photochemical organometallic bond activation

Dr. Graham Ball

David Hvasanov

Light-harvesting bioconjugates as chloroplast mimics

A/Prof. Pall Thordarson

Candidate

Rui Chen

35 37 39 41 43 45

53 55 57 59

Wei Jiang

Analysis and toxicity of heavy metals in the environment

Emeritus Prof. Brynn Hibbert

Adeline Lukmantara

Synthesis and structure-activity relationships studies of novel thiosemicarbazone derivatives as potential anti-cancer agents

Prof Naresh Kumar, Prof. David Black

Giulia Mancano

Organometallic chemistry and catalysis

Prof. Barbara Messerle

Pauline Michaels

Arsenic sensors

Scienta Prof. Justin Gooding

61 63 65 67 69 71 73 75

Ellaine Munton

Metrology in Analytical Chemistry

Emeritus Prof. Brynn Hibbert

Thi Oanh Nguyen

Iron, Rhodium and Iridium catalysts with N,N- and P,N-donor ligands for amine and alcohol synthesis

Prof. Barbara Messerle

Venty Suryanti

Self-assembly and anion recognition studies of N-Glyoxylamides

Prof Naresh Kumar, Prof. David Black

Marina Timerbulatova

Bimetallic complexes as catalysts for tandem reactions

Prof. Barbara Messerle

77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Scholarships Summer Scholarships Supervisor Raphael Hoikin Lam

Faculty

A/Prof. Naresh Kumar

Kiara Olrich

Faculty

Prof. Barbara Messerle

Erin Smith

Faculty

A/Prof. Jonathan Morris

Jonathon Ryan

School

A/Prof. Jonathan Morris

Stephen Wearmouth

School

A/Prof. Jonathan Morris

Kam Chung Hong

School

A/Prof. Naresh Kumar

Ming Han Eugene Yee

School

A/Prof. Naresh Kumar

Long Hua Chung

School

A/Prof. Steve Colbran

Tristan de Cure-Ryan

School

A/Prof. Steve Colbran

Christopher Redford

School

A/Prof. Steve Colbran

Christopher Barnett

School

Dr Jason Harper

Nicholas Konstandaras

School

Dr Jason Harper

James Caddy

School

Prof. Barbara Messerle

Brodie Cutmore

School

Scientia Prof. Justin Gooding

Practicum Students Home Institution

Supervisor

Erik Ekengard

Lund University, Sweden

A/Prof. Steve Colbran

Shay Mailoux

Clarkson University, USA

Scientia Prof. Justin Gooding

Chun Chieh Lin

San Diego State University

A/Prof Shelli McAlpine

Programs and Activities Royal Australian Chemical Institute – NSW Branch Report In 2012, the RACI NSW Branch once again benefited from its long-standing synergy with the School of Chemistry, UNSW. RACI deeply thanks the School for the continued provision of office space, meeting rooms, and seminar facilities, and for its continued engagement with the Institute. Your continued support greatly encourages all our volunteers. 2012 was packed with lots of educational and exciting functions and seminars with RACI reaching out to members and the general public. Some of the special events organised by the Branch include the NSW Titration Competition, which was administered by the Chemical Education Group, with UNSW again providing one of the Sydney venues. The Nyholm Youth Lecture Series continued with Dr Joseph Bevitt, Branch Secretary and member of the Bragg Institute, delivering lectures on ‘Chemistry of the Nucleus” at various venues including University of New England (Armidale), University of Sydney, University of Western

SECTION 04 Sydney, and as always the University of New South Wales. In 2013, Dr Neeraj Sharma from the School of Chemistry, UNSW, will be delivering the Nyholm Lectures on “Energy for the Future”, commencing on 12th June at Armidale. The Branch also continued its support of tours around NSW libraries of a series of International Year of Chemistry initiated and now Inspiring Australia program of the Department of Innovation, Industry, Science, Research and Tertiary Education–Questacon sponsored Exhibitions. In 2012, the “Healthy Chemistry” exhibition was installed in various metropolitan and country venues. During 2013 we have a different display, the “Material Futures” exhibition, visiting, in order, Orange, Singleton, Tamworth, Liverpool, Dubbo, Muswellbrook, Ryde, Questacon (ACT), Wagga Wagga, and Griffith. The NSW Branch has now kicked off the RACI Ambassador Program at the University of New South Wales, alongside Macquarie University and the University of Sydney, in the metropolitan area. Prof Martina Stenzel, National Hon Gen Secretary (CAMD, Chemical Engineering, UNSW), is leading this program with great support from the School of Chemistry. This program aims to reach out to all chemistry and chemistry related students, allowing RACI to provide valuable resources in terms of networking opportunities and information through seminars and symposia in 2013 and beyond. Ideas for future collaborative opportunities are always welcome. RACI NSW Branch actively participated in the UNSW Open Day; it was a great honour to have had a table in the School of Chemistry section on the day, and our volunteer booth staff were pleased to field questions and complement School of Chemistry demonstrations. Other 2012 events held at the University of New South Wales included the “Chemistry of Chocolate Evening”, as well as the “NSW Branch Organic Chemistry Group One Day Symposium” organised by A/Prof Jonathan Morris and Dr Luke Hunter, both from the School of Chemistry. In 2012, Dr Luke Hunter, in addition to his commitment in the Organic Chemistry Group, took up the role of the RACI NSW Branch Treasurer. Also, Stephen Parker of the Australian Centre for NanoMedicine, School of Chemistry, UNSW, became a member of the Analytical and Environmental Chemistry Group Committee. Members of the School were also recognised with awards. Firstly, undergraduate student, Vera Diachenko, won the RACI NSW Analytical Chemistry Group Prize for

best performance in Level 3 Analytical Chemistry in 2012. Associate Professors Shelli McAlpine and Marcus Cole were separately elected as new Fellows of the RACI, and Dr Pall Thordarson was awarded the Le Févre Memorial Prize from the Australian Academy of Science, an award administered by the RACI. It is noted that UNSW students were not amongst those receiving RACI Postgraduate Student Travel Awards in 2012. Student members are encouraged to apply for these and other RACI sponsored awards, including the Masson Memorial Prize (Honours thesis) and Cornforth Medal (PhD thesis). Staff members are of course open to various RACI research and educational National Awards. Many thanks again to the School of Chemistry, especially to Prof Barbara Messerle, Jodee, Lucy, Anne, Nick, Rick, Ken, and Terry, also to Ian and our friends in the Chemistry Store. The RACI NSW Branch is, as always, indebted to the support given to us by the School of Chemistry.

01 03 05 07 09 11 13 15 17 19 21 23 25 27 29 31 33 35 37

John Zavras

President – The Royal Australian Chemical Institute, NSW

Branch

43 45 47

UNSW Chemical Society

49 51

The UNSW Chemical Society assists in the organisation

of the School Seminar Series, a weekly program of talks

from distinguished academics around Australia and the

world. In addition the society organises a number of

59 61

prestigious, endowed lectureships each year, and in 2012

it played host to an eminent academic, Professor Phil

Baran from the Scripps Research Institute. Apart from

presenting his Howard lecture titled “Studies in Natural

69 71

Product Synthesis”, another benefit was the time he spent

in the School of Chemistry, interacting with both members

of staff and the student body.

77 79 81

The Howard Lecture, 18th September 2012

PROFESSOR PHIL BARAN,

85 87

Scripps Research Institute, USA

Studies in Natural Product Synthesis

91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

SECTION 05 01 03 05

STUDENTS

07 09 11 13 15 17

School of Chemistry Undergraduate Student Prizes

19 21 23 25 27

Honours Prize Winners

The Inglis Hudson and Jeffery Bequest Prize

The CETEC Prizes

Best performance in level 3 Organic

Best performance in Honours Thesis

Chemistry

Kiara Olrich

Chin Min Wong The Angyal Prize

The Bosworth Prize

Best performance in Honours

and Medal for best performance in

Chemistry

Level 3 Physical Chemistry

Chin Min Wong

Kiara Olrich

31 33

41 43 45 47 49

55 57

Third Year Prize Winners

The University of New South Wales Chemical Society Parke-Pope Prize

The Du Pont Prize

Meritorious performance in Level 3

Best performance in B.Sc. 3 Year

Chemistry Course

Degree in Chemistry,

Erin Smith

59 61 63 65 67 69 71

Overall â&#x20AC;&#x153;topâ&#x20AC;? of Chemistry Kiara Olrich

Second Year Prize Winners

The School of Chemistry Prize

The University of New South Wales Chemical Society George Wright Prize

73 75 77

Best performance in Level 3 Analytical Chemistry Vera Diachenko The University of New South wales Chemical Society Dwyer Prize Best performance in Level 3 Inorganic Chemistry Kiara Olrich

79 81 83 85

Meritorious performance in Level 2

Chemistry Courses

Sharon Yu

91 93 95

The School of Chemistry Prize and School Medal for best performance in Level 2 Chemistry Max Guerry

97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

First Year Prize Winners

UNSW Chemistry Video Competition Individual Prizes:

The June Griffith Memorial Prize and School Medal for best performance in Level 1 Chemistry

Michael Park (1st prize) Courtney Lum (Meritorious)

Courses

Team Prize

Ena Thea Luis

Francheska Domingo and Trisha Purvis

The University of New South Wales Chemical Society Prize Meritorious performance in Level 1

Postgraduate Prizes, Scholarships and Fellowships

Chemistry Courses Yas Eghtedari

Don Craig Memorial Prize For excellence in research using X-Ray

Year 10 Prize Winner

crystallography Alasdair McKay

The School of Chemistry Prize For Excellence and Enthusiasm in

Paddon-Row Scholarship

Chemistry for Year 10 Students

For the highest ranked commencing

Charmaine Li

local PhD student Alexander Mason

Undergraduate Scholarships and Awards

Black Scholarship For the highest ranked commencing

Howard Awards

international student

Laura Jeffress

Parisa Sowti Khiabani

Stephen Butler Paige Hawkins UNSW Faculty of Science Summer Vacation Research Scholarships Jeffrey Black Jacqueline Liu Albert Woffenden Sharon Yu

Teaching Fellowship Holders Jet Chang Sandra Choy Kyloon Chuah Michelle Dunn Dominic Francis Chris Gardner Mark Gatus Ethan How Sinead Keaveney Alex Mason Lyz Murago Justin Nash Andrew robinson

SECTION 05 Postgraduate Student Awards and Prizes Australian Institute of Nuclear Science and Engineering (AINSE) Stephen Parker (Supervisor, Scientia Professor Justin Gooding), Post Graduate Research Award (2011 – 2013) International Society of Electrochemistry Stephen Parker (Supervisor, Scientia Professor Justin Gooding), Poster Prize - “Towards Capture and Release of Circulating Tumour Cells (CTCs) Using Electrochemically-Switchable Surfaces”.

Catalysis & Energy: Eden Tanner (Supervisor, Dr Jason Harper) “ Does the cation really matter? The effect of modifying an ionic liquid cation on an SN2 process” Medicinal Chemistry: Ethan Howe (Supervisor, Dr Pall Thordarson) “Supramolecular Architecture Towards Mimicry of Allosteric Regulated Enzymes and Haem Proteins”

International Symposium on Macrocyclic and Supramolecular Chemistry

Molecular Devices: Roya Tavallaie (Supervisors, Scientia Professor Justin Gooding & Professor Brynn Hibbert) “Direct modification of gold coated magnetic nanoparticles with nitrophenyl groups by electrochemical reduction of in situ generated monodiazonium cations”

David Hvasanov (Supervisor, Dr Pall Thordarson), Poster Prize - “Photoinduced membrane proton pumping via polymersomes as chloroplast mimics”.

UNSW Medicinal Chemistry Drug Discovery Symposium

21st IUPAC Conference on Physical Organic Chemistry

01 03 05 07 09 11 13 15 17 19 21 23 25 27 29 31

Ming Han Yee (Supervisor A/Prof Naresh Kumar), Best oral presentation.

33 35 37 39 41 43 45

Eden Tanner (Supervisor Dr. Jason Harper) Poster Prize - “Does the cation really matter? The effect of the modifying an ionic liquid cation on the outcome of an SN2 process”

47 49 51 53 55

NewSouth Innovation

Xunyu Lu (Supervisor, Dr Chuan Zhao), Finalist – Best New Invention Award.

59 61 63 65

RACI 18 Australasian Electrochemistry Conference

67 69

Xunyu Lu (Supervisor, Dr Chuan Zhao) BloomGutmann Prize.

71 73 75 77

RACI Organic Division Travel Bursary

Dominic V. Francis (Supervisor Dr Jason Harper / A/ Prof. Roger Read).

81 83 85

Royal Society of Chemistry

David Hvasanov (Supervisor – Dr Pall Thordarson) Poster Prize - Photoinduced membrane protonpumping via polymersome as chloroplast mimics

89 91 93 95 97

School of Chemistry – Research Poster Prizes The three School Poster Prizes were awarded to:

Dr Jason Harper and his research group.

101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Profess Barbara Messerle and her research group

SECTION 05 Students of Chemistry Society 2012 was a hugely successful year for SOCS with all our

annual events and introduction of initiatives to get more

undergraduates involved.

05 07

The year started strong with the annual SOCS trivia

night. Hosted by Jason Harper, Jason Ashmore and

11 13

Stephen George. The night that was full of random facts,

glow sticks and rather obscure prizes that saw a new set

of trivia champions from the BAM and Field groups! This

year also saw the introduction of Battle of the Titans with

21 23

Mathew Gyton being declared champion.

25 27

First semester also included becoming affiliated with

Arc, having an O-Week stall, a number of undergraduate

morning teas, revamping of both the SOCS room and

lockers, a pub crawl and a number of BBQs.

35 37

Next up was the tenth annual Chemball, that saw a

record high 100 students dance the night away at

41 43

L’Aqua Goldroom at Darling Harbour. The evening

involved some chemistry games, the infamous chemistry

bingo and dry ice decorations. The night also included

a showdown over the best Gentleman and a special

51 53

rendition of Happy Birthday. The event was made

possible with a Student Community Development Grant

from Arc.

59 61

More recently, SOCS hosted it’s third annual international

SOCS had an amazing year due to the many hard

food night. With food from accross the world, it’s now

working students who volunteered their time and effort.

becoming one of our most popular events. A big shout

Some just to name a few include:

Michelle Dunn - President

Andrew Robinson - Treasurer

out to the cooks on the night. We also hosted the annual Honours hand in BBQ, along with the first Sports afternoon in conjunction with the School end-of-year Party.

Eden Tanner- Secretary

This year also saw an increased number of

Jonathan Carpentier - Activities Coordinator

undergraduates getting involved due to both the

Bradley Butler - Merchandising Officer

creation of new executive positions along with the continued operation of Dalton G06 as a SOCS common room, where students can study, relax and eat their lunch.

81 83

Stephen Parker - Publicity Officer

Ethan Truong – 3 Year Representative

89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

SECTION 06 01 03

SCHOOL

05 07 09 11 13 15

Staﬀ

17 19 21 23

Administration Head of School Professor Barbara Ann Messerle, BSc PhD Syd. Director of Research Associate Professor John Arron Stride, BSc (Hons.) PhD E.Anglia Director of Teaching Dr Gavin Leslie Edwards, BSc PhD Monash, CChem, MRACI

25 27 29 31 33 35 37 39 41 43 45

Postgraduate Coordinator

Associate Professor Jonathan Charles Morris, BSc UWA, PhD ANU

Postgraduate Studies Coordinator – Coursework

Professor David Brynn Hibbert, BSc PhD Lond., CChem, FRSC, FRACI

Higher Year (2nd – 4th year) Coordinator

Dr Marcus Lawford Cole, BSc (Hons) PhD Cardiff

First Year Coordinator

Dr Nicholas Kenneth Roberts, BSc PhD W.Aust., CChem, MRACI

67 69

Laboratory Coordinator

Associate Professor Stephen Boyd Colbran, BSc PhD Otago

73 75

IT Coordinator

Dr Ronald Stanley Haines, BSc PhD UNSW

79 81

Seminar Coordinator

Dr Chuan Zhao, BSc Shaanxi, MSc PhD Northwest UT

85 87

Outreach Coordinator

Associate Professor Naresh Kumar, MSc Punj., PhD W’gong., CChem, MRACI

91 93

Administrative Officer

Rick Sai Kin Chan, BBus Curtin, CPA

97 99

Office Administrator

101

Jodee Anning, BA UNSW

103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Teaching Staff

Research Staff

Professors

Professor Leslie D. Field (Deputy Vice Chancellor – Research)

David St Clair Black, MSc Syd., PhD Camb., AMusA, CChem, FRACI

Professor Margaret M. Harding (Pro Vice-Chancellor (Research Strategy) & Dean of Graduate Research)

(Scientia Professor) John Justin Gooding, BSc Melb., DPhil Oxon David Brynn Hibbert, BSc PhD Lond., CChem, MRSC, FRACI Barbara Ann Messerle, BSc PhD Syd.

Research Associates Manohari Abeysinghe, BSc, PhD Wales Mahiuddin Alamgir, B.Pharm (Hons), M.Pharm Jahangirnagar, PhD UNSW Simone Ciampi, BSc Modena, PhD UNSW

Associate Professors Stephen Boyd Colbran, BSc PhD Otago Marcus Lawford Cole, BSc (Hons) PhD Cardiff Naresh Kumar, MSc Punj., PhD W’gong., CChem, MRACI

Renxun Chen, BSc (Hons), PhD UNSW Milena Czyz, BSc Hons (Adelaide) PhD UNSW Nadim Darwish, BSc Lebanese, PhD UNSW James Garner, BSc, PhD N’cle (Aus)

Shelli Renee McAlpine, BSc Ill, PhD UCLA

Carolina Gimbert- Suriñach, PhD Universtat Autònoma de Barcelona

Jonathan Charles Morris, BSc UWA, PhD ANU

Bin Guan, PhD UNSW

John Arron Stride, BSc (Hons.) PhD E.Anglia

Alice Gui, PhD UNSW

Senior Lecturers

Xiang-Guo Hu, PhD, Institute of Chemistry, Chinese Academy of Sciences

Graham Edwin Ball, BSc PhD Sheffield, MRACI Gavin Leslie Edwards, BSc PhD Monash, CChem, MRACI Jason Brian Harper, BSc Adelaide, BSc ANU PhD ANU Nicholas Kenneth Roberts, BSc PhD W.Aust., CChem, MRACI Pall Thordarson, BSc Iceland, PhD Syd Chuan Zhao, BSc Shaanxi, MSc PhD Northwest UT

George Iskander, BSc MSc PhD Khartoum, FRSC, MRSC, RACI Guozhen Liu, BSc Hubei N.U., MSc C.U. Geosciences, PhD UNSW Hsiu Lin Li, BSc (Hons), PhD Monash David Hvasanov, PhD UNSW Xuechao Liu, BSc Normal, PhD Najing University Stuart Lowe, PhD Imperial College, London Alison Magill, BSc (Hons), PhD UTas

Lecturers

Thomas Martin, MChem, PhD, Bath University, UK

Leigh Aldous, BSc (Hon) Leeds, PhD Queen’s

Boon Ng, BSc, PhD, UTAS

Ronald Stanley Haines, BSc PhD UNSW

Michael Page, BSc (Hons 1), PhD, UNSW

Luke Hunter, BSc(Adv)(Hons), PhD USYD

Joshua Peterson, BSc Wash, PhD USyd

Neeraj Sharma, BSc (Hons) PhD USYD

Matthew Peterson, Deborah Ramsey, BSc Alabama, PhD Wake Forest

Associate Lecturer

Abdoreza Salek

Anna Choy, BSc (Hons), UNSW

Alexander Soeriyadi, PhD UNSW Gordon Sutton, BSc, PhD ANU Khuong Vuong, BSc, USyd, BSc (Hons 1, University Medal), PhD, UNSW James E.A. Webb, PhD, USYD Kasey Wood, BSc, PhD, UNSW Hon Man Yau, BSc, PhD, UNSW

SECTION 06 Visiting Fellows Emeritus Scientia Professor Michael Nicholas Paddon Row, BSc Lond, PhD ANU, CChem, FRSC, FRACI

Emeritus Professor Stephen John Charles Angyal, OBE, PhD Bud., DSc UNSW, FAA, FRACI Roger Bishop, BSc St And., PhD Camb., CChem, FRSC, FRACI

Conjoint Professors Grainne Mary Moran, BSc PhD NUI, CChem, MRACI

International Visiting Fellows Prof. Phil Baran, Scripps Research Institute Dr Ashok Nanjundan, Institute for Nanoscience and Cryogenics – Grenoble, France Prof. Catherine Ngila, University of Johannesburg – South Africa A/Prof. Soghra Khabnadideh, Shiraz University of Medical Sciences, Shiraz, Iran

01 03 05 07 09 11

Prof. Scott Rychnovsky, University of California Irvine

13 15

1st Year Casual Teaching Staff

Dr Kakali Chowdhury, PhD, Uni New Dehli, India

19 21

Joan P. Ross, BSc Syd.

23 25

Professorial Visiting Fellows

Professional and Technical Staff

Alan Norman Buckley, BSc Syd., PhD Monash, MRACI

Administrative Support

Anne Ayres

Michael James, BSc Syd, PhD Cambridge, MRACI Ronald Postle PhD Leeds

27 29 31

Kenneth Gerard McGuffin, BA Syd

37 39 41

Visiting Fellows Dr Nicholas Armstrong, B.App.Sc (Hons 1st), PhD UTS Dr Joseph John Brophy, BSc, PhD DSc UNSW, DipEd Monash, CChem, FRACI

Computer Officer

Ray Arnhold

45 47

Laboratory Manager Dr Toby Jackson

49 51 53 55

Dr Adam Cawley, Australian Racing Forensic Laboratory, NSW Dr Alex Falber, Algae Enterprises Ltd, Victoria, Australia Dr Suresh Govindaraghavan, Network Nutrition Pty Ltd

Technical Officers

Peta Di Bella, BSc (Hons) UQ

59 61

Lihn Cuba-Diem

Hitendra Gopal

Berta Litvak, BSc UTS, MEdAdmin UNSW

67 69

A/Prof. Roger Read, BSc PhD Syd., DIC Lond., CChem, FRACI

Michael McMahon

Dr Nancy Scoleri, BSc (Hon), PhD Adel.

A/Prof. Gary David Willett, BSc PhD LaT, CChem, MRACI

Svetislav Videnovic, BChemEng, Sarajevo

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School Store

Ian Aldred

Rama Anning

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Invited Lectures & Conference Presentations – Emeritus & Visiting Fellows Emeritus Professor Roger Bishop

Professorial Visiting Fellow, Mike James

Gao J., Bishop R., Bhadbhade M.M., Conference: “What makes a better host?”, 7th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC-7), Dunedin, NZ, 29 January – 2 February 2012.

M. James, “Neutron Scattering and Your Sense of Smell”, AsCA12, National Wine Centre, University of Adelaide, 5th December, 2012.

Bishop R., Gao J., Djaidi D., Bhadbhade M.M., Invited lecture: “A clathrate uncertainty principle”, Symposium: Transformations and Structural Oddities in Molecular Crystals: In Honor of Bruce M. Foxman, American Crystallographic Association Annual Meeting, Boston, MA, USA, 28 July – 1 August 2012. Gao J., Bishop R., Bhadbhade M.M., Conference: “Bicyclo[3.3.0]octane diols: a rich source of competing polymorph, co-crystal, solvate and apohost crystal forms”, Crystal & Graphene Science Symposium – 2012, Boston, MA, USA, 5 – 6 September 2012. Gao J., Bishop R., Bhadbhade M.M., Conference: “United we stand, divided we fall: structures of double guest inclusions of a compound where a single guest fails to include”, Asian Crystallographic Association AsCA 12 – Crystal 28 2012, Adelaide, 2 – 5 December 2012.

Dr Joseph Brophy Lawes, D., Brophy, J., Hnawia, E., Lebouvier, N., Nour, M. “Leaf Essential Oils of Some Eugenia (Myrtaceae) Species Endemic to New Caledonia”. RACI Natural Products Symposium, Sydney University, September 2012 Lawes, D., Brophy, J., Hnawia, E., Lebouvier, N., Nour, M. “Leaf, Wood and Bark Oils of Myodocarpus viellardii, a Species Endemic to New Caledonia”. RACI Organic Chemistry Symposium, UNSW, December 2012.

Invited Lectures:

M. James, “Behind the Razor Wire”, Australian Synchrotron Careers Forum, National Centre for Synchrotron Science, Australian Synchrotron, 2nd October, 2012. M. James, “Morphological Studies of Nanoscale Thin-Film Optoelectronic Devices Using Neutron Reflectometry”, 15th International Conference on Advances in Materials and Processing Technologies, Novotel Wollongong Northbeach Hotel, 24th September, 2012. M. James, “Molecular Deuteration of Biological and Chemical Species For Neutron Scattering”, Synchrotron and Neutron User Symposium, Australian Synchrotron, 9th July, 2012.

Conference Presentations: M. James, “The Australian Synchrotron Introduction and Applications”, National Characterisation Council Annual General Meeting, CSIRO North Ryde, June 12th, 2013. M. James, “Scientific Update From The Australian Synchrotron”, Australian Nuclear Science and Technology Organisation, 28th May 2013. M. James, “Studies of the nanoscale using very large (neutron and Synchrotron X-ray) facilities”, Issues in Nanotechnology Seminar Program, La Trobe University, April 16th, 2013. M. James, “Synchrotron X-rays and Neutrons: Why stop at once shining light?...”, Spring-8, Japan Synchrotron Radiation Research Institute (JASRI), Hyogo, Japan, March 7th, 2013. M. James, “Investigations of Peptide Interactions with Biological Membranes Using X-ray and Neutron Reflectometry”, Australian Colloid and Interface Symposium (ACIS2013), Outrigger Resort and Spa, Noosa, February 3rd-6th, 2013.

SECTION 06 M. James, “Studies of Nanoscale Water”, ANSTOSINAP Workshop, Lucas Heights Research Laboratories, Australia, 11th December 2012. S. Ciampi, J. J. Gooding, M. James, ““Click” Chemistry for the Functionalisation of Silicon for Chemical and Biological Sensing”, Structure and Dynamics of Condensed Matter by Scattering Methods Workshop – Professor John W. White Symposium, at Mercure Resort Hunter Valley Gardens, Australia, 25th - 28th November 2012. M. James, A. Nelson, S. Holt, T. Hsu, T. Saerbeck, D. Cortie, F. Klose, and A. Le Brun, “2009 – 2012: The Age of Platypus, Neutron Reflectometry at Australia’s OPAL Reactor”, Structure and Dynamics of Condensed Matter by Scattering Methods Workshop – Professor John W. White Symposium, at Mercure Resort Hunter Valley Gardens, Australia, 25th - 28th November 2012. M. James, “Neutron and X-ray Scattering at ANSTO”, SAS2012, International Small-Angle Scattering Conference, ANSTO, November 21st, 2012. Tamim Darwish, Emily Luks, Greta Moraes, Peter Holden, Michael James, “Molecular Deuteration for Contrast Variation in Neutron Studies of MultiComponent Nanoscale Systems”, SAS2012, International Small-Angle Scattering Conference, Sydney Exhibition and Convention Centre, Sydney, November 18th-23rd, 2012. M. James, “Complementary Techniques and Preliminary Characterisation”, Powder Diffraction at OPAL and at the Australian Synchrotron: Experiment Planning to Data Analysis, ANSTO, Lucas Heights, November 12th, 2012 M. James, A. Nelson, S. Holt, T. Hsu, T. Saerbeck, D. Cortie, F. Klose, and A. Le Brun, “2009 – 2012: The Age of Platypus Neutron Reflectometry at OPAL”, AINSE / ANBUG Neutron Scattering Symposium 2012, AINSE Lucas Heights Research Laboratories, Australia, 7th-9th November 2012. Peter. Holden, T. A. Darwish, A. P. Duff, M. Gillon, V. Lake, E. Luks, G. Moraes, A. Rekas, R. A. Russell, K. L. Wilde, R. Yepuri and M. James, “Molecular Deuteration at the National Deuteration Facility”, AINSE / ANBUG Neutron Scattering Symposium 2012, AINSE Lucas Heights Research Laboratories, Australia, 7th-9th November 2012.

P. Shaw, H. Cavaye, S. S. Y. Chen, M. James, I. R. Gentle and P. L. Burn, “Probing the absorption and release of nirtoaromatic vapours from fluorescent dendrimer films for the detection of explosives” AINSE / ANBUG Neutron Scattering Symposium 2012, AINSE Lucas Heights Research Laboratories, Australia, 7th-9th November 2012.

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M. James, “Neutrons and Nanoscience”, University of Wollongong Nanoscience Course, ANSTO, 27th August 2012.

Fact or Fiction: A series of presentations for Science Week, University of Western Sydney, August 3rd, 2012.

Peter. Holden, T. A. Darwish, A. P. Duff, M. Gillon, T. Hanley, V. Lake, E. Luks, G. Moraes, V. L. Peterson, A. Rekas, R. A. Russell, A. Sokolova, K. L. Wilde and M. James, “Molecular Deuteration at the Australian National Deuteration Facility for Investigations Using Cold and Thermal Neutron Scattering”. American Conference on Neutron Scattering, Georgetown University Hotel and Conference Center, Washington, DC 27th June, 2012. P. Burn, A. R. G. Smith, K. H. Lee, A. Nelson, M. James, I. R. Gentle, “Probing morphology and interfaces in organic optoelectronic films with neutrons”, ICONN2012, Perth Convention Centre, February 5-9, 2012.

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Professorial Visiting Fellow, Ron Postle Invited Professor, lecture courses and examinations,

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University of Haute Alsace, ENSISA, Mulhouse, France,

Jan 2012 and Nov - Dec 2012:

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Mechanics and Modelling of Soft Materials: Ecole Doctorale, Ecole Nationale Superieure des Ingenieurs Sud Alsace; PhD qualifying entrance, Masters degree; Undergraduate degree courses for Mechanical Engineering and Textile Engineering students.

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Plenary lecture, ‘Mechanics and Physics of Soft Matter: Knitted Fabrics’: 6th International Textile, Clothing & Design Conference, ITC&DC6, Dubrovnik, Croatia, October, 2012.

Research seminars, Heat and Mass Transfer through Absorbing Fibrous Materials. Technical University of Liberec, Czech Republic, November, 2012.

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Plenary lecture, ‘Micromechanics of Knitted Textile Structures as Soft Matter’. 19th International Conference Structure and Structural Mechanics of Textile Materials, Faculty of Textile Engineering, Technical University of Liberec, Czech Republic and Czech. Section, The Textile Institute, Manchester, UK, December 2012. Postgraduate research seminar, Micromechanics of Fibre Reinforced Composite Structures, University of Leeds, UK, Dec 2012.

Visiting Fellow, Associate Professor Roger Wayne Read 19th IUPAC International Conference on Organic Synthesis in conjunction with the 24th Royal Australian Chemical Institute Organic Conference, Melbourne, 1-6 July 2012. Poster presentation: “Progress in the Development of Functional Fluorous Surfactants”, D. V. Francis, J. B. Harper, A. I. Mohammed, R. W. Read. 20th International Symposium on Fluorine Chemistry, Osaka, Japan, 22-27 July 2012, Oral presentation: “Exploiting Functional Fluorous Triazoles and Tetrazoles”, D. V. Francis, A. I. Mohammed, R. W. Read, presented by D. V. Francis. 23rd Southern Highlands Conference on Heterocyclic Chemistry, Moss Vale, 26-28 August 2012. Poster presentation: “Two dibenzodiazepinone molecules with dissimilar dimeric associations and apparent different tautomerism”, M. M. Bhadbhade, M. Keller, R. W. Read, presented by R. W. Read. Royal Australian Chemical Institute NSW Branch Organic One-Day Symposium, UNSW, 5 December 2012. Poster presentation: “Progress in the Development of Functional Fluorous Surfactants”, D. V. Francis, J. B. Harper, A. I. Mohammed, R. W. Read.

SECTION 06 Publications & Patents Dr Leigh Aldous ‘Ionic Liquids for Lignin Processing: Dissolution, Isolation, and Conversion’ M. M. Hossain, L. Aldous, Australian Journal of Chemistry 2012, 65, 1465-1477. ‘Synthesis and characterization of carbon nanotubes covalently functionalized with amphiphilic polymer coated superparamagnetic nanocrystals’ J. C. Bear, P. D. McNaughter, K. Jurkschat, A. Crossley, L. Aldous, R. G. Compton, A. G. Mayes, G. G. Wildgoose, Journal of Colloid and Interface Science 2012, 383, 110-117. ‘The formal potentials and electrode kinetics of the proton/hydrogen couple in various room temperature ionic liquids’ Y. Meng, L. Aldous, S. R. Belding and R. G. Compton, Chemical Communications 2012, 48, 5572-5574. ‘One-step synthesis of fluorescein modified nano-carbon for Pd(II) detection via fluorescence quenching’ J. Panchompoo, L. Aldous, M. Baker, M. Wallace and R. G. Compton, Analyst 2012, 137, 2054-2062. ‘A Green Approach to Fenton Chemistry: MonoHydroxylation of salicylic acid in aqueous medium by the electrogeneration of Fenton’s reagent’, J. Panchompoo, L. Aldous, R. G. Compton, M. Kabeshov, B. Pilgrim and T. J. Donohoe, New Journal of Chemistry 2012, 36, 1265-1272. ‘The Hydrogen Evolution Reaction in a Room Temperature Ionic Liquid: Mechanism and Electrocatalyst Trends’, Y. Meng, L. Aldous, S. R. Belding and R. G. Compton, Physical Chemistry Chemical Physics 2012, 14, 5222-5228. ‘Volatilisation of substituted ferrocene compounds of different sizes from room temperature ionic liquids: a kinetic and mechanistic study’, C. P. Fu, L. Aldous, E. J. F. Dickinson, N. S. A. Manan and R. G. Compton, New Journal of Chemistry 2012, 36, 774-780. ‘The adsorption of quinizarin on boron-doped diamond’, I. B. Dimov, C. Batchelor-McAuley, L. Aldous and R. G. Compton, Physical Chemistry Chemical Physics 2012, 14, 2375-2380. ‘The Use of Nano-carbon as an Alternative to MultiWalled Carbon Nanotubes in Modified Electrodes for Adsorptive Stripping Voltammetry’, T. W. B. Lo, L. Aldous and R. G. Compton, Sensors & Actuators: B. Chemical 2012, 162, 361-368.

‘Electrochemistry of Zirconium Tetrachloride in the Ionic Liquid N-Butyl-N-methylpyrrolidinium Bis(trifluoromethylsulfonyl)imide: Formation of Zr(III) and Exploitation of ZrCl4 as a Facile Ionic Liquid Drying Agent’, C. P. Fu, L. Aldous, N. S. A. Manan and R. G. Compton, Electroanalysis 2012, 24, 210213.

‘Investigation of the optimal transient times for chronoamperometric analysis of diffusion coefficients and concentrations in non-aqueous solvents and ionic liquids’, L. Xiong, L. Aldous, M. C. Henstridge and R. G. Compton, Analytical Methods 2012, 4, 371-376.

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Dr Graham E. Ball Ball, G.E.; Andersen, R.A. “Stereodynamics in Eight-Coordination: A 2D NMR Spectroscopic and Computational Study of the Exchange Process in ThCl4(Me2NCH2CH2NMe2)2”, Inorg. Chem. 2012, 51, 10141–10147.

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Young, R.D.; Lawes, D.J.; Hill, A.F.; Ball, G.E. “Observation of a tungsten alkane σ-complex showing selective binding of methyl groups using FTIR and NMR spectroscopies” J. Am. Chem. Soc. 2012, 134, 8294–8297.

McSkimming, A.; Ball, G. E.; Bhadbhade, M. M.; Colbran, S. B. “Rhodium Complexes of a Chelating Ligand with Imidazol-2-ylidene and Pyridin-2-ylidene Donors: The Effect of C-Metalation of Nicotinamide Groups on Uptake of Hydride Ion” Inorg. Chem. 2012, 51, 2191.

Ball, G.E.; Cole, M.L.; McKay, A.I. “Low Valent and Hydride Complexes of NHC Coordinated Gallium” Dalton Trans, 2012, 41, 946.

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Emeritus Professor Roger Bishop Bishop R., Synthetic clathrate systems, in Supramolecular Chemistry: From Molecules to Nanomaterials, Gale P.A., Steed J.W. (eds.), Wiley, Chichester, pp. 3033-3056, ISBN 978-0-470-74640-0 (2012).

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Bishop R., New aspects of aromatic ...π and C-H...π interactions in crystal engineering, Ch. 2, pp. 41-77, The Importance of Pi-interactions in Crystal Engineering: Frontiers in Crystal Engineering, Vol, III, Tiekink E. R. T., Zukerman-Schpector J. (eds.), Wiley, Chichester, ISBN 978-0-470-98014-9 (2012). Bishop R., Design of clathrate compounds that use only weak intermolecular attractions, in the Research Front: Supramolecular Chemistry and Crystal Engineering, Aust. J. Chem., 2012, 65, 1361-1370. Bishop R., Gao J., Djaidi D., Bhadbhade M.M., A clathrate uncertainty principle, Trans. Am. Crystallogr. Assoc., 2012, 43, 34-44. Gao J., Bhadbhade M.M., Bishop R., Different crystal forms of a rich hydrogen bond acceptor compound resulting from alternative C-H…O and orthogonal C=O…C=O molecular interaction patterns, CrystEngComm, 2012, 14, 138-146. Gao J., Bhadbhade M.M., Bishop R., Polymorphic crystals formed by an achiral diol under ambient conditions, Cryst. Growth Des., 2012, 12, 5746-5756. Hemtasin C., Ung A.T., Kanokmedhakul S., Kanokmedhakul K., Bishop R., Satraruji T., Bishop D., Synthesis of alkaloid-like compounds via the bridging Ritter reaction, Monatsh. Chem., 2012, 143, 955-963. Suryanti V., Bhadbhade M., Bishop R., Black D.S.C., Kumar N., Self-assembly of alkyl N-acetylglyoxylic amides of varying chain length, CrystEngComm, 2012, 14, 7345-7354.

Chen, R., Bhadbhade, M., Kumar, N and Black, D. StC., Synthesis of cyclic tetraindolyls via oxidative coupling reactions, Tetrahedron Letters, 53, 33373341 (2012). Deodhar, M., Wood, K., Black, D. StC., and Kumar, N., Oxidative dimerisation of isoflavones: synthesis of kudzuisoflavone A and related compounds, Aust. J. Chem., 65, 1377-1383 (2012). Sengul, I. F., Wood, K., Bowyer, P. K., Bhadbhade, M., Chen, R., Kumar, N. and Black, D. StC., Synthesis of new di-(3-indolyl)arenes, Tetrahedron, 68, 7429-7434 (2012). Mitchell, P. S. R., Sengul, I. F., Kandemir, H., Nugent, S. J., Chen, R., Bowyer, P. K., Kumar, N. and Black, D. StC., Bromination of 4,6-dimethoxyindoles, Tetrahedron, 68, 8163-8171 (2012). Chawla, H, M., Santra, A., Pant, N., Kumar, N. and Black, D. StC., Evaluation of deep cavity imidazolylcalix[n]arenes for selective extraction of silver, J. Incl. Phenom. Macrocycl. Chem., 73, 55-65 (2012). Suryanti, V., Bhadbhade, M., Bishop, R., Black, D. StC. and Kumar, N., Self-assembly of alkyl N-acetylglyoxylic amides of varying chain lengths, Cryst. Eng. Comm., 14, 7345-7354 (2012). Sengul, I. F., Wood, K., Kumar, N. and Black, D. StC., Synthesis of macrocyclic systems derived from di(2-indolyl)heteroarenes, Tetrahedron, 68, 9050-9055 (2012).

Dr Joseph Brophy Professor David St Clair Black Devakaram, R., Black, D. StC. And Kumar, N., An efficient synthesis of 2,4-disubstituted tetrahydroquinolines and quinolines, Tetrahedron Letters, 53, 2269-2272 (2012). Devakaram, R., Black, D. StC., Choomuenwai, V., Davis, R. A. and Kumar, N., Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b] chromene derivatives, Bioorg. Medicinal Chem., 20, 1527-1534 (2012). Somphol, K., Santoso, M., Bhadbhade, M., Gardner, C., Kumar, N. and Black, D. StC., Synthesis of mixed cyclotriveratrylenes, Tetrahedron, 68, 1862-1868 (2012)

Hnawia, E., Brophy, J.J., Craven, L.A., Lebouvier, N., Cabalion, P., Nour, M., A preliminary examination of the leaf essential oils of the endemic Melaleuca (Myrtaceae) species of New Caledonia. J. Essent. Oil Res., 24, 273-278 (2012).

Professorial Visiting Fellow, Alan Buckley Parker, G.K., Hope, G.A., Woods, R., Numprasanthai, A., Buckley, A.N., McLean, J. Investigation of n-octanohydroxamate reagent interaction with the surface of oxide copper minerals and copper metal. Separation Technologies for Minerals, Coal, and Earth Resources, C.A. Young, G.H. Luttrell, Editors, SME Inc., Colorado, 2012, pp. 497–508.

SECTION 06 Hope, G.A., Buckley, A.N., Parker, G.K., Numprasanthai, A., Woods, R., McLean, J. The interaction of n-octanohydroxamate with chrysocolla and oxide copper surfaces. Minerals Eng., 36–38 (2012) 2–11. Hope, G.A., Numprasanthai, A., Buckley, A.N., Parker, G.K., Sheldon, G. Bench-scale flotation of chrysocolla with n-octanohydroxamate. Minerals Eng., 36–38 (2012) 12–20. Parker, G.K., Buckley, A.N., Woods, R., Hope, G.A. The interaction of the flotation reagent, n-octanohydroxamate, with sulfide minerals. Minerals Eng., 36–38 (2012) 81–90. Cui, J., Hope, G.A., Buckley, A.N. Spectroscopic investigation of the interaction of hydroxamate with bastnaesite (cerium) and rare earth oxides. Minerals Eng., 36–38 (2012) 91–99. Buckley, A.N., Denman, J.A., Hope, G.A. The adsorption of n-octanohydroxamate collector on Cu and Fe oxide minerals investigated by static secondary ion mass spectrometry. Minerals, 2 (2012) 493–515.

Associate Professor Stephen Boyd Colbran McSkimming, A.; Bhadbhade, M. M.; Ball, G. E.; Colbran S. B., Rhodium complexes of a chelating ligand with imidazol-2-ylidene and pyridin-2-ylidene donors: the effect of C-metalation of nicotinamide groups on uptake of hydride ion, Inorganic Chemistry, 2012, 51, 2191–2203. Nilsson, J; Colbran, S. B.; Behrens, U.; Rehder, D.; Nordlander, E. The redox interaction between vanadyl cation and tris(6-(2-hydroxymethl) pyridylmethyl)amine, Inorganica Chimica Acta, 2012, 392, 490–493. Gimbert-Surinach, C.; Bhadbhade, M.; Colbran, S. B. Bridgehead hydrogen atoms are important: unusual electrochemistry and proton reduction at iron dimers with ferrocenyl substituted phosphidebridges, Organometallics, 2012, 31, 3480–3491. Redford, C.; Gimbert-Surinach, C.; Bhadbhade, M.; Colbran, S. B. trans-Chloridobis(4-picoline) (4,4’,4’’-tritert- butyl-2,2’:6’,2’’-terpyridine) ruthenium(II) hexafluorophosphate acetone solvate, Acta Crystallographica Section E, 2012, E68, m300.

Associate Professor Marcus Lawford Cole Dunn, MD; Cole, ML; Harper JB: Effects of an ionic liquid solvent on the synthesis of gammabutyrolactones by conjugate addition using NHC organocatalysts, RSC Advances, 2012, 2, 1016010162. McKay, AI; Ball, GE; Cole, ML: Low valent and hydride complexes of NHC coordinated gallium and indium, Dalton Trans, 2012, 41, 946-952. Bruce, MI; Büschel, S; Cole, ML; Scoleri, N; Skelton, BW; White, AH: Some chemistry of trans-Ru(C≡CC≡CH)2(dppe)2: Syntheses of bi- and tri-metallic derivatives and cycloaddition of tcne, Inorg. Chim. Acta, 2012, 382, 6-12.

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Professor Leslie D. Field

Gilbert-Wilson, R., Field, L. D. and Bhadbhade, M. M., New Super-hindered Polydentate Polyphosphine Ligands P(CH2CH2PtBu2)3, PhP(CH2CH2PtBu2)2, P(CH2CH2CH2PtBu2)3 and their Ruthenium (II) Chloride Complexes, Inorg. Chem., 2012, 51 (5), pp 3239–3246.

Leslie D. Field, Hsiu L. Li, Scott J. Dalgarno, Ruaraidh D. McIntosh, Side-on Bound Complexes of Phenyl- and Methyl-diazene, Inorg. Chem. 2012, 51, 3733-3742.

Rumble, Sarah L.; Page, Michael J.; Field, Leslie D.; Messerle, Barbara A., In Situ Catalysts for the Intramolecular Hydroamination of Aminoalkynes – What Ligand Properties Determine Catalyst Activity?, Eur J. Inorg. Chem., 2012, 2012(13), 2226-2231. Leslie D. Field, Multiple-quantum spectroscopy in liquid crystalline solvents, in Encyclopedia of NMR, Harris, Robin Kingsley; Wasylishen, Roderick E (Eds), John Wiley&Sons, Chichester, UK, 2012, 5, 2900-2909.

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Scientia Professor J. Justin Gooding

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S. Ciampi, B. Guan, N. Darwish, Y. Zhu, P.J. Reece, J.J. Gooding, A Multimodal Optical and Electrochemical Device for Monitoring Surface Reactions: Redox Active Surfaces in Porous Silicon Rugate Filters, Phys. Chem. Chem. Phys. 14 1643316439 (2012).

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X.Y. Cheng, R. Gondosiswanto, S. Ciampi, P.J. Reece, J.J. Gooding, One-pot synthesis of colloidal silicon quantum dots and surface functionalization via thiol-ene click chemistry, Chem. Comm. 48 11874-11876 (2012).

X. Chen, E. Luais, N. Darwish, S. Ciampi, P. Thordarson, J.J. Gooding, Studies on the Effect of Solvents on Self-Assembled Monolayers Formed from Organophosphonic Acids on Indium Tin Oxide, Langmuir 28 9487-9495 (2012).

N. Darwish, P.K. Eggers, S. Ciampi, Y. Tong, S. Ye, M.N. Paddon-Row, J.J. Gooding, Probing the effect of the solution environment around redox active moieties using rigid anthraquinone terminated molecular rulers, J. Am. Chem. Soc. 134 18401−18409 (2012).

B. Guan, S. Ciampi, M. James, P.J. Reece, J.J. Gooding, Depth-resolved Chemical Modification of Porous Silicon by Wavelength-tuned Irradiation, Langmuir 28 15444-15449 (2012). X. Chen, X.Y. Cheng, J.J. Gooding, Detection of trace nitroaromatic isomers using indium tin oxide electrodes modified using β-cyclodextrin and silver nanoparticles, Anal. Chem. 84 8557-8563 (2012). N. Darwish, I. Díez-Pérez, S. Guo, N. Tao, J.J. Gooding, M.N. Paddon-Row, Single molecular switches: electrochemical gating of a single anthraquinone-based norbornylogous bridge molecule, J. Phys. Chem. C 116 21093-21097 (2012). D.D. Liana, B. Raguse, J.J. Gooding, E. Chow, Recent Advances in Paper-Based Sensors, Sensors 12 11505-11526 (2012). J.Q. Liu, R. Wang, L. Cui, J. Tang, Z. Liu, Q. Kong, W. Yang, J.J. Gooding, Using Molecular Level Modification to Tune the Conductivity of Graphene Papers, J. Phys. Chem. C 116 17939-17946 (2012). S. Ciampi, B. Guan, N. Darwish, P.J. Reece, J.J. Gooding, Redox-Active Monolayers in Mesoporous Silicon, J. Phys. Chem. C 116 16080-16088 (2012). C.C.A. Ng, A. Magenau, S.H. Ngalim, S. Ciampi, M. Chockalingham, J.B. Harper, K. Gaus, J.J. Gooding, Using Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion, Angew. Chem. Int. Ed. 51 7706-7710 (2012). G.Z. Liu, S.G. Iyengar, J.J. Gooding, An Electrochemical Impedance Immunosensor Based on Gold Nanoparticle-Modified Electrodes for the Detection of HbA1c in Human Blood, Electroanalysis 24 1509-1516 (2012).

J.Q. Liu, J. Tang, J.J. Gooding, Strategies for Chemical Modification of Graphene, J. Mater. Chem. 22 12435-12452 (2012). Y. Lu, J.R. Peterson, J.J. Gooding, A.N. Lee, Development of Sensitive Enzyme-linked Immunosorbent Assays (ELISAs) for Monitoring Bisphenol-A in Foods and Beverages, Anal. Bioanal. Chem. 403 1607-1618 (2012). P.K. Eggers, N. Darwish, M.N. Paddon-Row, J.J. Gooding, Surface-Bound Molecular Rulers for Probing the Electrical Double Layer, J. Am. Chem. Soc. 134 7539-7544 (2012). X. Chen, X. Cheng, J.J. Gooding, Multifunctional Modified Silver Nanoparticles as Ion and pH Sensors in Aqueous Solution, Analyst 137 2338-2343 (2012). N. Darwish, I. Diez-Pérez, P. Da Silva, N.J. Tao, J.J. Gooding, M.N. Paddon-Row, Observation of Electrochemically Controlled Quantum Interference in a Single Anthraquinone-based Norbornylogous Bridge Molecule, Angew. Chem. Int. Ed. 51 32033206 (2012). K. Chuah, L.M.H. Lai, I.Y. Goon, R. Amal, J.J. Gooding, Ultrasensitive electrochemical detection of prostate-specific antigen (PSA) using gold-coated magnetic nanoparticles as ‘dispersible electrodes’, Chem. Comm. 48 3503-3505 (2012). J. J. Gooding, N. Darwish, The Rise of SelfAssembled Monolayers for Fabricating Electrochemical Biosensors – An Interfacial Perspective, The Chemical Record 12 92-105 (2012). G.Z. Liu, S.M. Khor, S.G. Iyengar, J.J. Gooding, Development of an Electrochemical Immunosensor for the Detection of HbA1c in Serum, Analyst 137 829-832 (2012). S. Ciampi, M. James, G. Le Saux, K. Gaus, J.J. Gooding, Electrochemical ‘Switching’ of Silicon(100) Modular Assemblies for Cell Biology, J. Am. Chem. Soc. 134 844-847 (2012).

SECTION 06 N. Darwish, P.K. Eggers, P. Da Silva, Y. Zhang, Y. Tong, S. Ye, J.J. Gooding, M.N. Paddon-Row, Electroactive self-assembled monolayers of unique geometric structures using rigid norbornylogous bridges, Chem. Eur. J. 18 283-292 (2012).

Ng, M. C. C.; Harper, J. B.; Stampfl, A. P. J.; Kearley, G. J.; Rols, S.; Stride, J. A.: “Central atom size effects on the methyl torsions of group XIV tetratolyls”, Chemistry – A European Journal 2012, 18, 13018-13024.

T. Böcking, K.A. Kilian, P.J. Reece, K. Gaus, M. Gal, J.J. Gooding, Biofunctionalization of free-standing porous silicon films for self-assembly of photonic devices, Soft Matter 8 360-366 (2012).

Yau, H. M.; Croft, A. K.; Harper, J. B.: “One-Pot Hammett Plots: A General Method for the Rapid Aquisition of Relative Rate Data”, Chemical Communications 2012, 48, 8937-8939.

C. Hua, W.H. Zhang, S.R.M. De Almeida, S. Ciampi, D. Gloria, G. Liu, J.B. Harper, J.J. Gooding, A Novel Route to Copper Detection Using ‘Click’ ChemistryInduced Aggregation of Gold Nanoparticles, Analyst 137 82-86 (2012).

Ng, C. C. A.; Magenau, A.; Ngalim, S. H.; Ciampi, S.; Chockalingham, M.: Harper, J. B.; Gaus, K.; Gooding, J. J.: “Using Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion,” Angewandte Chemie, International Edition 2012, 51, 7706-7710.

J.J. Gooding, G.Z. Liu, A.L. Gui, The use of Aryl Diazonium Salts in the Fabrication of Biosensors and Chemical Sensors, in Aryl Diazonium Salts – New Coupling Agents in Polymer and Surface Science, Ed. M.M. Chehimi, Wiley-VCH, Germany Ch 9 pp197-218 (2012), ISBN 978-3-527-32998-4. B. Gupta, B. Guan, P.J. Reece, J.J. Gooding, Porous silicon photonic crystals for detection of infections, Biosensors and Nanomedicine V, San Diego 12 Aug (2012), Proc. SPIE 8460 Art. No. 846000Z (2012).

Yau, H. M.; Croft, A. K.; Harper, J. B.: “Investigating the origin of entropy-derived rate accelerations in ionic liquids”, Faraday Discussions 2012, 154, 365-371. Hua, C.; Zhang, W. H.; De Almeida, S. R. M.; Ciampi, S.; Gloria, D.; Liu, G.; Harper, J. B.; Gooding, J. J.: “A novel route to copper(II)detection using ‘click’ chemistryinduced aggregation of gold nanoparticles” Analyst 2012, 137, 82-86..

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Patents:

Professor D. Brynn Hibbert

J.J. Gooding, G. Liu, Electrochemical Sensor, Australian International Patent Application, 2006901394; Filing Date: 17/03/2006, PCT/ AU2007/000337. (2007), European patent appl. EP07718585.8 (EP2005161) Licensed. US patent 12/293272 Granted 26/9/11; Australian patent 2007229320 Granted 10/1/2013

Hibbert, D. B. Experimental design in chromatography: A tutorial review. J. Chromatogr. B, 910 (2012) 2– 13. DOI:10.1016/j. jchromb.2012.01.020

T. Böcking, J.J. Gooding, K.A. Kilian, M. Gal, K. Gaus, Method of Component Assembly on a Substrate, USA Complete No. 11/933541 (2007), PCT: AU08/001616, Chinese patent granted, Sold to Intellectual Ventures

Dr Jason Brian Harper Dunn, M. H.; Cole, M. L.; Harper, J. B.: “Effects of an ionic liquid solvent on the synthesis of γ-butyrolactones by conjugate addition using NHC organocatalysts”, RSC Advances 2012, 2, 1016010162.

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Munton, E., Liu, F.-H., Murby, E. John, & Hibbert, D. Brynn (2012). Certification of steroid carbon isotope ratios in a freeze-dried human urine reference material. Drug Testing and Analysis, 4(12), 928 – 933. DOI: 10.1002/dta.1366

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Wei Jiang, D. Brynn Hibbert, Grainne Moran and Rabeya Akter, Measurement of gold and sulfur mass fractions in L-cysteine-modified gold nanoparticles by ICP-DRC-MS after acid digestion: validation and uncertainty of results, J. Anal. At. Spectrom., 2012, 27 (9), 1465 – 1473

W. Bich, M.G. Cox, R. Dybkaer, C. Elster, W.T. Estler, B. Hibbert, H. Imai, W. Kool, C. Michotte, L. Nielsen, L. Pendrill, S. Sidney, A.M.H.v.d. Veen, W. Wöger, Revision of the ‘Guide to the Expression of Uncertainty in Measurement’ Metrologia, 49 (6) (2012) 702 - 705.

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Dr Luke Hunter Yamamoto, I.; Jordan, M. J. T.; Gavande, N.; Doddareddy, M. R.; Chebib, M.; Hunter, L. “The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor,” Chemical Communications 2012, 48, 829. Hunter, L. “α,β-Difluoro-γ-amino acids: synthesis and applications,” Chimica Oggi [Chemistry Today] 2012, 30, 20. Wang, Z.; Hunter, L. “Synthesis of difluorinated βand γ-amino acids: investigation of a challenging deoxyfluorination reaction,” Journal of Fluorine Chemistry 2012, 143, 143. Hunter, L., Butler S.; Ludbrook S. B., “Solid-phase synthesis of peptides containing backbonefluorinated amino acids,” Organic and Biomolecular Chemistry 2012, 10, 8911. Harty, D. S.; Farahani, R. M.; Simonian, M. R.; Hunter, L.; Hunter, N. “Streptococcus gordonii FSS2 challisin affects fibrin clot formation by digestion of the αC region and cleavage of the N-terminal region of the Bβ chains of fibrinogen,” Thrombosis and Haemostasis 2012, 108, 236.

T. Saerbeck, F. Klose, A.P. Le Brun, J. Füzi, A. Brule, A. Nelson, S. Holt, and M. James, “Polarization ‘Down Under’: The polarized time of flight neutron reflectometer PLATYPUS”, Review of Scientific Instruments, 83(8), 081301 (2012). DOI: 10.1063/1.4738579 D. Hong, Y. Yoon, K. Shin, M. James, G. Tae, “Mimicking the receptor-aided binding of HIV-1 Tat protein transduction domains onto phospholipid monolayers at the air/water interface”, Soft Matter, 8(33), 8616-8623 (2012). DOI: 10.1039/c2sm25885d P.-W. Yang, T.-L. Lin, I-T. Liu, Y. Hu and M. James, “Insitu Neutron Reflectivity Studies on the Adsorption of DNA by Charged Diblockcopolymer Monolayer at the Air-water Interface”, Soft Matter, 8(27), 71617168 (2012). DOI: 10.1039/c2sm25297j (IF: 4.39) M. Dimitrijev-Dwyer, L. He, M. James, A. Nelson, L. Wang, A. P. J. Middelberg, “The effects of acid hydrolysis on protein biosurfactant molecular, interfacial, and foam properties: pH responsive protein hydrolysates”, Soft Matter, 8(19), 5131-5139 (2012). (IF: 4.39) DOI: 10.1039/c2sm25082A

Professorial Visiting Fellow, Mike James

A. P. Le Brun, J. Y. H. Chow, A. Nelson, A. S. Weiss and M. James, “Molecular Orientation of Tropoelastin is Determined by Surface Hydrophobicity”, Biomacromolecules, 13(2), 379-386 (2012). DOI: 10.1021/bm201404x

B. Guan, S. Ciampi, E. Luais, M. James, P. J. Reece, J. J. Gooding, “Depth-resolved Chemical Modiﬁcation of Porous Silicon by Wavelength-tuned Irradiation”, Langmuir, 28(44), 15444−15449 (2012). DOI: 10.1021/la303649u

A. R. G. Smith, K. H. Lee, A. Nelson, M. James, P. L. Burn and I. R. Gentle, “Diffusion – the Hidden Menace in Organic Optoelectronic Devices”, Advanced Materials, 24(6), 822-826 (2012). DOI: 10.1002/adma.201104029

D. I. Fernandez, A. P. Le Brun, T. C. Whitwell, M.-A. Sani, M. James and F Separovic, “The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism”, Physical Chemistry Chemical Physics, 14(45), 15739-15751 (2012).

T. A. Darwish, A. R. G. Smith, I. R. Gentle, P. L. Burn, E. Luks, G. Moraes, M. Gillon, P. J. Holden and M. James, “Deuteration of conjugated aromatic heterocycles for morphological studies of organic light emitting devices”, Tetrahedron Letters, 53, 931–935 (2012). DOI: 10.1016/j.tetlet.2011.12.032

DOI: 10.1039/c2cp43099a T. A. Darwish, Y. Tong, M. James, T. L. Hanley, Q. Peng and S. Ye, “Characterizing the Photoinduced Switching Process of a Nitrospiropyran SelfAssembled Monolayer Using In Situ Sum Frequency Generation Spectroscopy”, Langmuir, 28(39), 1385213860 (2012). DOI: 10.1021/la302204f D. L. Cortie, K-W. Lin, C. Shueh, X. L. Wang, M. James, H. Fritzsche, S. Brück, and F. Klose, “Exchange bias in a nanocrystalline hematite/ permalloy thin ﬁlm investigated with polarised neutron reﬂectometry”, Physical Review B, 86(5), 054408 (2012). DOI: 10.1103/PhysRevB.86.054408

S. Ciampi, M. James, G. Le Saux, K. Gaus, and J. J. Gooding, “Electrochemical ‘Switching’ of Silicon(100) Modular Assemblies”, Journal of the American Chemical Society, 134, 844-847 (2012). DOI: 10.1021/ja210048x J.-P. Veder, K. Patel, M. Sohail, S. P. Jiang, M. James, R. De Marco, “An Electrochemical Impedance Spectroscopy/Neutron Reﬂectometry Study of Water Uptake in the Poly(3,4-Ethylenedioxythiophene): Poly(Styrene Sulfonate)/Polymethyl MethacrylatePolydecyl Methacrylate Copolymer Solid-Contact Ion-Selective Electrode”, Electroanalysis, 24(1), 140145 (2012). DOI: 10.1002/elan.201100524

SECTION 06 Associate Professor Naresh Kumar Chen, R., Willcox M. D. P., Cole, N., Ho, K. K. K., Rasul, R., Denman, J. A., and Kumar, N., (2012) Characterization of chemoselective surface attachment of the cationic peptide melimine and its effects on antimicrobial activity. Acta Biomaterialia 8:4371-4379. Chen, R., Bhadbhade, M., Kumar, N., and Black, D. StC. (2012) Synthesis of macrocyclic tetraindolyls via oxidative coupling reactions. Tetrahedron Letters. 53:3337-3341. Chawla, H. M., Santra, A., Pant, N., Kumar, S., Kumar, N., and Black, D. StC., (2012) Evaluation of deep cavity imidazolylcalix[n]arenes for selective extraction of silver. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 73:55-65. Deodhar, M., Wood, K., Black, D. StC., and Kumar, N. (2012) Synthesis of oxygenated 4-arylisoflavans and 4-arylflavans. Tetrahedron Letters. 53:6697-6700. Deodhar, M., Wood, K., Black, D. StC., and Kumar, N. (2012) Oxidative Dimerisation of Isoflavones: Synthesis of Kudzuisoflavone A and Related Compounds. Australian Journal of Chemistry. 65:1377-1383. Sengul, I. F., Wood, K., Bowyer, P. K., Bhadbhade, M., Chen, R., Kumar, N., and Black, D. StC. (2012) Synthesis of new di-(3-indolyl)arenes. Tetrahedron. 68:7429-7434. Devakaram, R., Black, D. StC., Choomuenwai, V., Davis, R. A., and Kumar, N. (2012) Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b] chromene derivatives. Bioorganic & Medicinal Chemistry 20: 1527-1534. Somphol, K., Santoso, M., Bhadbhade, M., Gardner, C., Kumar, N., and Black, D. StC. (2012) Synthesis of mixed cyclotriveratrylenes. Tetrahedron 68:1862-1868. Devakaram, R., Black, D. StC., and Kumar, N. (2012) An efficient synthesis of novel 2,4-disubstituted tetrahydroquinolines and quinolines, Tetrahedron Letters 53(18): 2269-2272. Gardner, C. R., Cheung, B. B., Koach, J., Black, D. StC., Marshall, G. M., and Kumar, N. (2012) Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy. Bioorganic & Medicinal Chemistry. 20:6877-6884.

Ho, K., Cole, N., Chen, R., Willcox, M. D. P., Rice, S., Kumar, N. (2012) Immobilisation of antibacterial dihydropyrrol-2-ones onto functional polymer supports to prevent bacterial infections in vivo. Antimicrobial Agents and Chemotherapy 56(2): 1138-1141.

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Mitchell, P. S. R., Sengul, I. F., Kandemir, H., Nugent, S. J., Chen, R., Bowyer, P. K., Kumar, N., and Black, D. StC. (2012) Bromination of 4,6-dimethoxyindoles. Tetrahedron. 68:8163-8171.

Sengul, I. F., Wood, K., Kumar, N., and Black, D. StC. (2012) Synthesis of macrocyclic systems derived from di-(2-indolyl)heteroarenes. Tetrahedron. 68:9050-9055.

Suryanti, V., Bhadbhade, M., Bishop, R., Black, D. StC., and Kumar, N. (2012) Self-assembly of alkyl N-acetylglyoxylic amides of varying chain lengths. CrystEngComm. 14:7345-7354.

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Patents Willcox, M.D.P.; Kumar, N., Chen, R.; Cole, N. Antimicrobial compounds and uses thereof. PCT International Application (2012), PCT/ IB2012/056599.

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Willcox, M.D.P.; Kumar, N.; Cole, N. Antimicrobial peptides modified for mammalian cell recognition and/or adhesion. Australian Provisional Patent Application (2012), 2012904455.

Kumar, N., Kutty, S.; Barraud, N., Rice, S. Dual action nitric oxide donors and their use as antimicrobial agents. Australian Provisional Patent Application (2012), 2012904909.

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59 61 63 65 67 69

Associate Professor Shelli Renee McAlpine

Synthesis, structure-activity analysis, and biological evaluation of structurally related conformational isomers; Hendra Wahyudi, Worawan Tantisantisom, Xuechao Liu, Deborah M. Ramsey, Erinprit K. Singh, and Shelli R. McAlpine* J. Org. Chem. v77, p1059610616, 2012

A new Hsp90 inhibitor that exhibits a novel biological profile; Deborah M. Ramsey, Jeanette R. McConnell, Leslie D. Alexander, Kaishin W. Tanaka, Chester M. Vera, and Shelli R. McAlpine* Bioorganic and Med. Chem. Lett. v22, p3287-3290, 2012

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Progress towards the synthesis of Urukthapelstatin A and two analogs; Chung-Mao Pan, Chun-Chieh Lin, Seong Jong Kim, Robert P. Sellers, and Shelli R. McAlpine* Tetrahedron Letters, v53, p4065-4069, 2012

Kim, H. J.; Qiao, Q.; Toop, H. D.; Morris, J. C.; Don, A. S. ‘A fluorescent assay for ceramide synthase activity’, J. Lipid Research, 2012, 53, 1701 – 1707.

Total Synthesis of Natural Product trans,transSanguinamide B and its structurally related conformational isomers; Erinprit K. Singh, Deborah M. Ramsey, and Shelli R. McAlpine* Org. Lett. v14, p1198-1201, 2012

Professorial Visiting Fellow, Ron Postle

Synthesis of Sansalvamide A Peptidomimetics: Triazole Oxazole, Thiazole, and Pseudoproline containing compoundsMelinda R. Davis, Erinprit K. Singh, Hendra Wahyudi, Leslie D. Alexander, Joseph Kunicki, Lidia A. Nazarova, Kelly A. Fairweather, Andrew Giltrap, Katrina A. Jolliffe, and Shelli R. McAlpine* Tetrahedron, v68, p1029-1051, 2012

Professor Barbara Anne Messerle Chin-Min Wong, Khuong Q. Vuong, Mark R. D. Gatus, Carol Hua, Mohan Bhadbhade and Barbara A. Messerle* Catalysed Tandem C-N/C-C Bond Formation for the Synthesis of Tricyclic Indoles using Ir(III) Pyrazolyl-1,2,3-Triazolyl Complexes, Organometallics, 2012, 31 (21), 7500–7510,. Katherine Gray, Michael J. Page, Jörg Wagler and Barbara A. Messerle*, Ir(III) Cp* Complexes for the Efﬁcient Hydroamination of Internal Alkynes, Organometallics, 2012, 31 (17), 6270–6277 Carol Hua, Khuong Q. Vuong, Mohan Bhadbhade and Barbara A. Messerle New Rhodium(I) and Iridium(I) Complexes Containing Mixed Pyrazolyl-1,2,3-Triazolyl Ligands as Catalysts for Hydroamination, Organometallics, 2012, 31 (5),1790–1800 Sarah L. Rumble, Michael J. Page, Leslie D. Field, Barbara A. Messerle, “ In situ Catalysts for the Intramolecular Hydroamination of Aminoalkynes – What Ligand Properties Determine Catalyst Activity?”, Eur J. Inorg Chem., 2012, 13, 2226–2231.

Associate Professor Jonathan Charles Morris Wilde, V. L.; Morris, J. C.; Phillips, A. J. “Marine Natural Product Synthesis”. In Handbook of Marine Natural Products; Fattorusso, E.; Taglialatela-Scafati, O.; Gerwick, W. H., Eds.; Springer, 2012; 601-673 (DOI: 10.1007/978-90-481-3834-0_11).

‘Mechanics and Physics of Soft Matter: Knitted Fabrics’. The Magic World of Textiles. Proc 6th International Textile, Clothing & Design Conference, ITC&DC6, University of Zagreb, Croatia, October, 2012 (ISSN 1847-7275) pages 3-14; Also published in the scientific journal Tekstil special edition 2012 (Croatian language). ‘Micromechanics of Knitted Textile Structures as Soft Matter’. Structure and Structural Mechanics of Textile Fabrics, STRUTEX, (ISBN 978-80-7372913-4) Liberec, Czech Republic, 2012, (Also to be published, Journal of Composites, 2013). ‘Influence of Knitted Fabric Construction on the Ultraviolet Protection Factor of Greige and Bleached Cotton Fabrics’. Wai-yin Wong, Jimmy Kwok – Cheong Lam, Chi-wai Kan (Hong Kong Polytechnic University) and Ron Postle (UNSW), Textile Research Journal, publication online Nov 27, 2012, (DOI 10.1177/0040517512467078).

Honorary Associate Professor Roger Read R. W. Read, X. Wang, A structure–function study of the surface tension changes of m-xylene in the presence of fluorous 1H-1,2,3-triazoles and tetrazoles, J. Fluorine Chem., 2012, 135, 25-32. M. Keller, M. M. Bhadbhade, R. W. Read, Two dibenzodiazepinone molecules with dissimilar dimeric associations and apparent different tautomeric forms, Acta Cryst., 2012. C68, o240–o246. M. Hamzeloo Moghadam, H. Hajimehdipoora, S. Saeidnia, A Atoofi, R. Shahrestani, R. W. Read, Mahmoud Mosaddegh, Anti-proliferative Activity and Apoptotic Potential of Britannin, a Sesquiterpene Lactone from Inula aucheriana, Nat. Prod. Commun., 2012, 7, 979-980.

SECTION 06 Dr Neeraj Sharma C.-Y. Chiang, H.-C. Su, P.-J. Wu, H. Liu, C.-W. Hu, N. Sharma, V. K. Peterson, H.-W. Hsieh, Y.-F. Lin, W.-C. Chou, C.-H. Lee, J.-F. Lee, B.-Y. Shew, Vanadium substitution of LiFePO4 cathode materials to enhance the capacity of LiFePO4-based lithium-ion batteries, Journal of Physical Chemistry C, 116, 24424−24429 (2012) Y. Sang, D. Yu, M. Avdeev, R. O. Piltz, N. Sharma, N. Ye, H. Liu, J. Wang, X-ray and neutron diffraction studies of flux and hydrothermally grown nonlinear optical material KBe2BO3F2, CrystEngComm, 14, 6079-6084 (2012) Z. Peining, W. Yongzhi, M. V. Reddy, A. Sreekumaran Nair, P. Shengjie, N. Sharma, V. K. Peterson, B. V. R. Chowdari, S. Ramakrishna, TiO2 nanoparticles synthesized by the molten salt method as a dual function material for dye-sensitized solar cells, RSC Advances, 2, 5123-5126 (2012) N. Sharma, G. Du, Z. Guo, J. Wang, Z. Wang, V. K. Peterson, Direct evidence of concurrent solidsolution and two-phase reactions and the nonequilibrium structural evolution of LiFePO4, Journal of the American Chemical Society, 134, 7867-7873 (2012) D. Li, Y. D. Huang, N. Sharma, Z. X. Chen, D. Z. Jia, Z. P. Guo, Enhanced electrochemical properties of LiFePO4 by Mo-substitution and graphitic carboncoating via a facile and fast microwave-assisted solid-state reaction, Physical Chemistry Chemical Physics, 14, 3634-3639 (2012) W. Miiller, M. Avdeev, Q. Zhou, B. J. Kennedy, N. Sharma, R. Kutteh, G. J. Kearley, S. Schmid, K. S. Knight, P. E. R. Blanchard, C. D. Ling, Giant magnetoelastic effect at the opening of a spin-gap in Ba3BiIr2O9, Journal of the American Chemical Society, 134, 3265-3270 (2012) R. J. Gummow, N. Sharma, V. K. Peterson, Y. He, Crystal chemistry of the Pmnb polymorph of Li2MnSiO4, Journal of Solid State Chemistry 188, 32-37, (2012) J. Auckett, A. J. Studer, N. Sharma, C. D. Ling, Floating-zone growth of Sr2Fe2O5 and observation of a chain-ordered superstructure by single-crystal neutron diffraction, Solid State Ionics 225, 432-436 (2012)

R. P. Rao, N. Sharma, V. K. Peterson, S. Adams, Variation in Structure and Li+-ion Migration in Argyrodite-type Li6PS5X (X = Cl, Br, I) Solid Electrolytes, Journal of Solid State Electrochemistry, 16, 1807-1813 (2012) N. Sharma, V. K. Peterson, In situ neutron diffraction experiments on lithium-ion batteries, Journal of Solid State Electrochemistry, 16, 1849-1856 (2012) R. J. Gummow, N. Sharma, V. K. Peterson, Y. He, Synthesis, structure and electrochemical performance of magnesium substituted lithium manganese silicate cathodes for lithium-ion batteries Journal of Power Sources, 197, 231-237 (2012).

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Associate Professor John Arron Stride

25 27

Adsorption and Desorption Characteristics of 3-dimensional Networks of Fused Graphene; M. Choucair, N.M.K. Tse, M.R. Hill and J.A. Stride, Surf. Sci., 2012, 606, 34.

The gram-scale synthesis of carbon onions; M. Choucair and J.A. Stride, Carbon, 2012, 50, 1109.

Engineering Solvothermal Reactions to Produce Multi-walled Carbon Nanotubes; M. Choucair, B. Gong and J.A. Stride, J. Nano Part. Res., 2012, 14, 901.

Central atom size effects on the methyl torsions of group XIV tetratolyls; M.C.C. Ng, J.B. Harper, A.P.J. Stampfl, S. Rols, G.J. Kearley and J.A. Stride, Chem., Eur. J., 2012, 18, 13018.

Highly Luminescent Quantum Dots: New Tools for Biological Applications; F.M. Najafi Zadeha, F. Wang, P. Reece and J.A. Stride, NSTI-Nanotech 2012, 1, 441. ISBN 978-1-4665-6274-5..

31 33 35 37

45 47 49 51

55 57 59 61 63 65 67 69 71 73

Dr Pall Thordarson

75 77 79

Journal publications:

Ethan N. W. Howe, Mohan Bhadbhad and Pall Thordarson*, Highly sheared anti-parallel dipolar carbonyl•••carbonyl interaction in the crystal packing of strapped crown-3-pyromellitimide, Australian Journal of Chemistry, 2012, 65, 13841389.

83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Xin Chen, Erwann Luais, Nadim Darwish, Simone Ciampi, Pall Thordarson and J. Justin Gooding, Studies on the Effect of Solvents on Self-Assembled Monolayers Formed from Organophosphonic Acids on Indium Tin Oxide, Langmuir, 2012, 28, 94879495. Adam J. Lowe, Frederick Pfeffer, Pall Thordarson, Determining binding constants from 1H NMR titration data using global and local methods: a case study using [n]polynorbornane based anion hosts, Supramolecular Chemistry, 2012, 24, 585-594. Amy R. Mulholland, Pall Thordarson, Emily J. Mensworth, Steven J. Langford, Porphyrin Dyads Linked by a Rotatable 3,3’-Biphenyl Scaffold: A New Binding Motif for Small Ditopic Molecules, Org. Biomol. Chem., 2012, 10, 6045-6053. K. Kobayashi, D. Cheng, M. Huynh, K. R. Ratinac, P. Thordarson, F. Braet, Imaging Fluorescently Labeled Complexes by Means of Multidimensional Correlative Light and Transmission Electron Microscopy: Practical Considerations, Methods in Cell Biology, 2012, 111, 1-20. Book Chapters: Pall Thordarson, “Binding Constants and their Measurement” in Supramolecular Chemistry: From Molecules to Nanomaterials, Vol 1, Ed. J. W. Steed and P. A. Gale, John Wiley & Sons, Chichester, UK, 2012, 239-274. D. Hvasanov, D. C. Goldstein and P. Thordarson, “Light-Activated Bioconjugate Complexes in Molecular Solar Fuels (Book Series: Energy), Ed. T. Wydrzynski and W. Hillier, Royal Society of Chemistry, Cambridge, UK, Cambridge, UK, 2012, 426-447.

Dr Chuan Zhao Chuan Zhao, Alan M. Bond and Xunyu Lu, Determination of water in room temperature ionic liquids by cathodic stripping voltammetry at a gold electrode, Anal. Chem. 2012, 84 (6), 2784–2791 Xunyu Lu, Geoff Burrell, Frances Separovic and Chuan Zhao, Electrochemistry of room temperature protic ionic liquids: a critical assessment for use as electrolytes in electrochemical applications, J. Phys. Chem. B, 2012, 116, 9160−9170

Bryan H. R. Suryanto, Christian A. Gunawan, Xunyu Lu and Chuan Zhao, Tuning the electrodeposition parameters of silver to yield micro/nanostructures from room temperature protic ionic liquids, Electrochim. Acta, 2012, 81, 98-105 Christian A. Gunawan, Bryan H. R. Suryanto and Chuan Zhao, Electrodeposition of metals from room temperature protic ionic liquids, J Electrochem. Soc., 2012, 159(10), D611-D615 Gianluca Bernardini, Anthony G. Wedd, Chuan Zhao and Alan M. Bond, Photochemical oxidation of water and reduction of polyoxometalate anions at interfaces of water with ionic liquids or diethylether, Proc. Acad. Nat. Sci., 2012, 109, 11552-11557 Gianluca Bernardini, Anthony G. Wedd, Chuan Zhao and Alan M. Bond, Electrochemical probing of the photoreduction of molybdenum and tungsten Dawson-type polyoxometalates in molecular and ionic liquid media using water as an electron donor, Dalton Trans, 2012, 41 (33), 9944 – 9954 Stefania Piantavigna, Muhammad E. Abdelhamid, Anthony P. O’Mullane, Chuan Zhao, Xiaohu Qu, Bim Graham, Leone Spiccia, Lisandra Martin, Binary switch activity of the Tat peptide: from membrane penetration to lytic action, Journal of Peptide Science, 2012, 18, 80.

Patents Chuan Zhao, “Determination of water in nonaqueous media”, Australian patent AU2012900577 Chuan Zhao, Xunyu Lu, “Stable and more efficient carbon electrodes”, Australian Patent AU2012904329 Chuan Zhao, Xunyu Lu, “Carbon electrodes”, Australian Patent AU2012904330

SECTION 06 Grants and Research Fellowships AUSTRALIAN RESESARCH COUNCIL 01 03

Discovery Projects (new & continuing funding)

05 07

Investigator(s)

Project

Scientia Prof. JJ Gooding

230,000

Making Silicon Even More Useful: Functionalising Silicon to Produce Stable Electronic Devices in Aqueous Environments

Kumar N; Prof. Black D; Prof. Willcox M

100,000

Disrupting Chemical Communication in Bacteria: A Novel and Effective Antimicrobial Strategy

A/Prof M.L. Cole

110,000

Thallium Hydride Complexes – Synthesis, stabilisation and synthetic Utility

Scientia Prof. JJ Gooding, Prof.PJ Reece

150,000

Smart surfaces for monitoring cellular activity in real time: from multiple to single cells

Prof. D.B. Hibbert

100,000

Maximum entropy methods for Bayesian analysis in chemistry

100,000

Boron and silicon based pincer ligands for environmentally responsible catalysis

Prof. A.F. Hill, Prof. B.A. Messerle Dr C. Zhao

130,000

Tuning the electrolytes for high efficiency star splitting of water

Dr L. Hunter

125,000

Fluorinated amino acids: building blocks for the synthesis of shape-controlled bioactive peptides (New)

Prof. A.F. Hill, Prof. B.A. Messerle

130,000

Turning homogeneous catalysts into heterogeneous catalysts: Robust linking of organometallic complexes onto inert carbon supports (New)

Dr P. Thordarson, Dr C. Zhao

110,000

Photochemical and Electrochemical Control of Redox Enzyme Cascades (New)

LIEF Grants - Linkage Infrastructure, Equipment and Facilities

31 33 35 37 39 41 43 45 47 49 51 53

Investigator(s)

Project

Dr. Boecking, Prof. Gaus, Scientia Prof. Gooding, Prof. Gunning, Prof. Hardeman

250,000

Multi-mode fluorescence microscope for visualising the dynamics of cellular processes at the single-molecule level,

55 57 59 61

Linkage Program (new & continuing funding)

63 65

Investigator(s)

Project

115,000

New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness

Scientia Prof. J.J. Gooding & S Iyengar (AgaMatrix Inc) Prof. M. Manefield, Scientia Prof. J.J. Gooding, S. Lam

200,000

In situ biomediation solutions for Australia’s organochlorine contaminated aquifiers

A/Prof. N. Kumar, M. Willcox, N. Cole

97,000

Antimicrobial contact lens cases

Prof. M. Willcox, A/Prof. N. Kumar, N. Cole, N. James

100,000

Novel antimicrobial surface coatings for biomedical applications

71 73

81 83 85

Future Fellowship

87 89

Investigator(s)

Project

102,857

Moving Supramolecular Assembly of Functional Systems into Water

Dr Pall Thordarson

95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

NATIONAL HEALTH & MEDICAL RESEARCH COUNCIL Investigator(s)

Project

A/Prof K. Gaus, Scientia Prof J.J. Gooding

184,500

The implications of focal adhesion organization on signal transduction

Prof. P. Lewis, A/ Prof. R. Griffith, A/Prof N. Kumar

85,000

Exploitation of bacterial transcription initiation as a target for new antimicrobials

Scientia Prof J.J. Gooding, A/Prof N. Di Girolamo, Prof D. Wakefield

147,000

A nanomedicine strategy for detecting and modulating protease activity in vivo (New)

UNIVERSITY OF NEW SOUTH WALES GRANTS Faculty Research Grants Investigator(s)

Dr GE Ball

10,000

Project Metal-alkane complexes: are they stable enough to be isolated?

A/Prof SB Colbbran

24,000

Artificial transition metal hydrogenases

A/Prof JA Stride

18,500

Achieving switchable magnetism in framework materials

Major Equipment and Infrastructure Scheme Investigator(s)

Project

Dr L. Aldous, A/Prof JA Stride

89,539

Pfeiffer OmniStar - A Mass Spectrometer Attachment for TGA/DSC

Dr GE Ball, Dr JB Harper, A/Prof SB Colbran, Prof DB Hibbert

35,000

Compact Linux cluster for applications in computational chemistry, and molecular modelling

Dr L. Hunter, A/Prof Jonathan Morris, A/Prof Shelli McAlpine, A/Prof Naresh Kumar, Dr Pall Thordarson, Prof Brett Neilan

90,375

Preparative HPLC

Dr P. Thordarson, Dr C. Zhao

89,546

Rheology facility for soft-material and ionic liquid characterization

Investigator(s)

Project

Dr. JB Harper, Dr Lawrence T. Scott

40,000

Getting the reaction outcomes you want in ionic liquids: Towards solvent-controlled reactivity

A/Prof P. Thordarson

40,000

Supramolecular gels: Molecular design of smart assemblies

Investigator(s)

Project

Dr Leigh Aldous

9,382

Investigating chlorine oxide species in ionic liquids: towards green biomass processing

Investigator(s)

Project

Dr L. Hunter

13,215

Fluorinated cyclic peptides: lead compounds for anti-angiogenic tumour therapy

Goldstar

ECR Funding

SFRGP Funding

SECTION 06 AUSTRALIAN GRANTS Investigator(s) Prof Ron Postle (and 10 others)

$ 10,000,000 (2007 – 2014)

Project

Source

CRC for Sheep Industry Innovation

Australian Wool Testing Authority, CSIRO & The University of California

01 03

A/Prof N. Kumar

78,162

Isoflavone analogues

Novogen Ltd

Scientia Prof JJ. Gooding

3,250,000 (over 3 years)

Sensor Systems for Analysis of Aquatic Environments

CSIRO Flagship Collaboration

Dr JJ. Brophy, Dr LA. Craven, Dr JC Doran

8,000

The Melaleuca Book

Rural Industries Research and Development Corporation (RIRDC)

Dr P. Thordarson, Prof F. Braet (USyd)

50,000

Self-assembled gels for local anticancer drug delivery

NSW Cancer Institute Research Innovation Grant

200,000

Extending the science curriculum: teaching instrumental science at a distance in a global laboratory using a collaborative electronic laboratory notebook

Prof DB Hibbert, Dr Frey, Prof Mocerino, A/Prof Todd, Miansup, Dr Quinnell

Australian Learning & Teaching Council

25 27

10,000

Quality control of herbal medicine extracts

Network Nutrition

101,139

Synthesis and characterisation of Metal-Organic frameworks for CO2 capture

CSIRO SIEF

Prof DB Hibbert

100,000

An Integrated Instrumental Approach for Tracking Pollution to Source

UNSW EPA Trust

Prof DB Hibbert

10,000

Analysis of arsenic in racehorses

Australian Racing Forensic Laboratory

A/Prof Kumar N; Prof. Willcox M; Cole N

50,000

Dr N Verrills, Dr A Don, Dr A Enjeti, A/Prof JC Morris

120,000

Dr N Verrills, Dr A Don, Dr A Enjeti, A/Prof JC Morris

Antimicrobial contact lens cases

AINSE

A/Prof JA Stride, A/Prof ML Cole, et al

8,430

Prof DB Hibbert

07 09

Structural evolution of selfassembled gels for biomedical applications

Dr P. Thordarson

29 31 33 35 37 39 41 43 45 47 49 51

Brien Holden Vision Institute

53 55

Activating a tumour suppressor for leukaemia therapy

Cancer Council NSW

(New)

Activating a tumour suppressor for leukaemia therapy

Cure Cancer Australia Foundation (New)

100,000 100,000

Australian Institute of Nuclear Science and Engineering (New)

Dr N. Sharma

Developing improved materials for energy generation and storage

30,000

Synthesis and optical properties of novel perylene arrays

Enterprise Australia – Researcher in Business Award (New)

Dr A. Falber, Dr P. Thordarson

11,000

Development of Fluorescent media to enhance nutritional algae growth

Enterprise Australia – Researcher in Business Award (New)

Dr A. Falber, Dr P. Thordarson

75 77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

INTERNATIONAL GRANTS Investigator(s)

Project

Source

Prof. Ron Postle

HK$450,000

Ultraviolet protection of knitted textile materials and clothing

Hong Kong Research Grants Commission, in co-operation with Institute of Textile and Clothing, Hong Kong Polytechnic University.

Prof. Ron Postle

HK$1,770,000

Designing and engineering lightweight knitwear fabrics with ultraviolet protection function

HK Innovation and Technology Programme, ITF

Prof. AJ Phillips, A/ Prof JC Morris, Prof. CJ Stephenson

US$90,000

Robust New Chemistries for Heterocycles

National Institutes of Health

A/Prof Shelli McAlpine

305,000

Conformational based Design and development of antitumor agentsâ&#x20AC;?

National Institutes of Health

Profess Barbara Messerle and her research group

SECTION 06 Industry and Community Interaction 01

Listed below are the companies, government authorities,

Scientia Professor Justin Gooding

societies and educational institutions that academic staff interacted with in 2012.

03 05

Consultant for the following companies:

07 09

AgaMatrix Inc

Inventia Pty Ltd

Dr Leigh Aldous

15 17 19

Collaboration with the following companies (plus donation of research samples):

Dr Jason Brian Harper

SunRice Australia

PhD examiner for the following institution:

Micro Milling Pty Ltd.

University of Melbourne

Macadamias Direct

Emeritus Professor Roger Bishop

31 33

Beacon Ionic Liquid Local Interest Group (BILLIG)

Goulbourn Valley Water

Research Output & Career Standing Evaluator for the National Research Foundation of South Africa. Member of Editorial Advisory Board of Journal of Inclusion Phenomena and Macrocyclic Chemistry, and of Current Organic Chemistry.

Consultant:

Member of the International Advisory Committee, International Conference on the Chemistry of the Organic Solid State (ICCOSS).

Professorial Visiting Fellow Alan Buckley Consultant for the following companies: Australian Metallurgical Services Pty Ltd Orica Mining Chemicals Clariant (Australia) Pty Ltd

Associate Professor Stephen Boyd Colbran

39 41

Professor D. Brynn Hibbert

Research Professor Assessor for the National University of Singapore.

Consultant:

Specialised Assessor for the ARC Future Fellowships and Discovery Projects Schemes.

Assessor for the National Research Foundation of South Africa: Blue Skies Research Proposal.

45 47 49 51

Legal Aid NSW

Gajic Lawyers

LSB Lawyers

57 59

Network Nutrition

King & Mallesons

Carmody Lawyers

65 67

NSW Department of Environment and Climate Change

E-Nose Pty. Ltd

Australian Forensic Drug Laboratory

Australian Racing Forensic Laboratory

National Measurement Institute

81 83

Troy laboratories

Apex laboratories

87 89

Queensland Racing

NSW Government

Bannisters Lawyers

95 97 99 101

PhD examiner for the following institution: University of Queensland

103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Dr Luke Hunter

Visiting Professorial Fellow, Ron Postle

PhD examiner for the following institution:

PhD examiner for the following institutions:

Monash University

Ecole Nationale Supériere des Ingeneurs, Sud Alsace, University of Haute Alsace, Mulhouse, France

Collaboration: GlaxoSmithKline England & Wales

Consultancies / Collaborations:

Visiting Professorial Fellow Mike James PhD examiner for the following institution: University of New South Wales MSc examiner for the following institution: University of Auckland, NZ

Associate Professor Naresh Kumar Collaborations: Brien Holden Vision Institute Centre for Marine Bio-Innovation Lowy Cancer Research Centre Network Nutrition Pty Limited

Associate Professor Shelli McAlpine PhD examiner for the following institutions: University of Cape Town, South Africa San Diego State University, USA

Professor Barbara Ann Messerle PhD examiner for the following institutions:

Australian member, Federation of Asian Professional Textile Associations, FAPTA AWTA, Australian Wool Testing Authority, Melbourne. Wool fibre measurement and tactile sensory perception Australian Wool Innovation, AWI and University of California, Davis, USA. Development and calibration of PhabrOmeter instrument for quality control of textile chemical finishing in industry Industry Research and Development, LMPT, Mechanics and Physics Laboratories, CNRS and Louis Pasteur University, University of Strasbourg, France. Medical textile applications: Vascular Graft and Heart Valve Prostheses N. Schlumberger, Guebwiller, Alsace, France on recycling textile and composite materials University of Nancy and Ecole des Mines, Paris. Computer imaging of three-dimensional textile materials and objective specification of large complex deformations Development of knitted fabric structures for ultraviolet protection in collaboration with fibre, chemical, textile and apparel manufacturing industries in China and Hong Kong Research and development for supersoft lightweight textile materials in collaboration with chemical and fibre industries, Textile Machinery Society of Japan, Osaka

University of Sydney.

International Scientific Committees:

Nanyang Technological University, Singapore

Associate Professor Jonathan Morris

AUTEX (Association European University Textile Departments) annual conference, Dresden, Germany and Examiner, Simulation and Modeling Section

PhD examiner for the following institutions:

International Textile, Clothing and Design Conference, ITC&DC, Dubrovnik (Croatia), Oct 2012

Monash University The University of Sydney The University of Queensland

SECTION 06 Structure and Structural Mechanics of Textile Materials, STRUTEX Conference, Technical University of Liberec, Faculty of Textile Engineering, Czech Republic, December 2012 Director, Genetic Eye Foundation, Department of Ophthalmology, Prince of Wales Hospital, Sydney Life member and former Chairman of Directors, Radio for the Print Handicapped Cooperative NSW Limited (2RPH) Member and former President, Retina Australia

Associate Professor John Arron Stride PhD examiner for the following institutions: University of Sydney

01 03 05

Dr Pall Thordarson

07 09

PhD examiner for the following institutions:

11 13

University of Queensland.

University of Sydney (MSc review)

17 19

Honorary Visiting Associate Professor Roger Read

Consultant & contract research: Algae Enterprise

PhD examiner for the following institutions:

Aquazure

21 23

La Trobe University University of Sydney

Grant Review Foundation for Polish Science

31 33 35 37

Consultant:

Shelston IP.

Dr Chuan Zhao

41 43

Referee for the following journals: Tetrahedron Chinese Journal of Chemistry Journal of Organic Chemistry Natural Product Reports Australian Journal of Chemistry

Collaboration & Consultantcy:

Cochlear Ltd. (collaboration)

Zenogen Pty Ltd, Sydney (consultancy)

51 53 55 57 59 61 63

Dr Neeraj Sharma

65 67 69

PhD examiner for the following institutions:

University of Auckland, New Zealand

73 75

Collaborations: Advanced Lithium Electrochemistry Company, Taiwan Ford Motor Company, Research and Advanced Engineering, USA

77 79 81 83 85 87 89

Representative: Of UNSW at the National Youth Science Forum events

91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Undergraduate and Postgraduate Enrolments Enrolment statistics 2012 2006

2007

2008

2009

2010

2011

2012

TOTAL EFTSU in the School of Chemistry

360

394

437

458

514

517

537

EFTSU: Undergraduate component

312

346

375

381

422

415

393

ENROLMENTS in CORE CHEMISTRY COURSES First Year

1422

1575

1495

1521

1844

1966

Second Year

282

257

256

231

219

336

352

Third Year

158

159

164

182

137

102

187

Level III CHEM electives

First Year

647

741

824

878

898

954

1024

Second Year

103

275

367

Third Year

HONOURS

*31

*22

ENROLMENTS in SERVICE COURSES

Total POSTGRADUATE COURSEWORK STUDENTSe Master of Science and Technology (Program 8708)

Graduate Diploma (Program 5648)

Graduate Certificate (Program 7428)

MSc (Research) Program 2910

PhD Program 1870

POSTGRADUATE RESEARCH STUDENTS

* BSc(Nanotechnology) students are included in the totals

SECTION 06 Honours Enrolments The following Honourts students were enrolled during all or part of the 2012 reporting period. Student

Supervisor

Sam Andrews

A/Prof. Naresh Kumar

Kai Buys

A/Prof. Marcus Cole

Hubert Chan

Dr Chuan Zhao

Kevin Coangharja

Scientia Prof. Justin Gooding

Tristan de Cure-Ryan

Prof. Brynn Hibbert / A/Prof. Grainne Moran

Rob Dwyer

A/Prof. Jonathan Morris

Christian Gunawan

Dr Chuan Zhao

Therese Hadjia

Dr Leigh Aldous

Kenneth Hong

A/Prof. Naresh Kumar

Peter Jurd

Prof. Les Field/Dr Alison Magill

Sinead Keaveney

Dr Jason Harper

Alistair Laos

Dr Pall Thordarson

Aggie Lawer

Dr Luke Hunter

Lev Lewis

Dr Pall Thordarson

Devi Dwijayanthi Liana

Scientia Prof. Justin Gooding

Ban Lieu

A/Prof Naresh Kumar

Renecia Lowe

Dr Luke Hunter

Alex Mason

Dr Pall Thordarson

Clara Ng

A/Prof. Marcus Cole

Chris Pracey

Postgraduate Coursework Enrolments The following postgraduate coursework students were enrolled during all or part of the reporting period for 2012

01 03 05

Graduate Diploma in Chemical Analysis and Laboratory Management (Program 5648)

07 09 11

Fiona COTTER

Wenwen FAN

15 17

Graduate Certificate in Chemical Analysis and Laboratory Management (Program 7428) Huiping HUANG

19 21 23 25 27

Master of Science and Technology in Chemical Analysis and Laboratory Management (Program 8708 - MScTech)

29 31 33 35 37 39

Khadijah ALAITHAN

Sooaad Awdah ALSHAHRANI

Rasha Ali ALASMARI

Khadijah ALSHANQITI

Karma ALBALAWI

Fatemah ALSHEHRI

Mashael Tayih S ALHARBI

Raed Dakhel ALSOBHI

Pankaj Kumar BARAI

Dr Graham Ball/Dr Larry Wakelin

Mohammed Theyab ALHARBI

Anna Nina CHUA

Brent HARRISON

Richard Gondosiswanto

Scientia Prof. Justin Gooding

Turki Hamid H ALHIJI

Huiping HUANG

Chris Redford

A/Prof. Steve Colbran

Hajar Hmoud ALHWAITI

Juo-Chieh LEE

Caroline Santoso

A/Prof Naresh Kumar

Amenh Hmod ALJOHANI

Yuvixza LIZARME SALAS

Bryan Suryanto

Dr Chuan Zhao

Tian LUO

Eden Tanner

Dr Jason Harper

Eman Abdullah ALJOHANI

Mohammad HABL ALMATIN

Zhouyue LV Thi Nguyet Thu NGUYEN

Shaun Thomson

A/Prof. Steve Colbran

Jonatan Wangsahardja

Dr Luke Hunter

Chin Wong

Prof. Barbara Messerle

Eugene Yee

A/Prof. Naresh Kumar

Amy Zhang

A/Prof. Jonathan Morris

Eiman M ALAHMADI

Anhar Ali ALMUBASHIR Jameel Ali M ALQAHTA Thamer Sulaiman ALRADDADI

41 43 45 47

61 63

Oluseyi O. OHUNAYO

Kylie OLUFSON

Violeta STOJANOVIC Johan VAN DEN BOSCH

83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Postgraduate Research Enrolments The following postgraduate research students were enrolled during all or part of the reporting period for 2012

Master of Science by Research (Program MSc2910 & MPhil 2475) Candidate

Research Area

Supervisor

Lachlan CARTER

Nanoparticle-mediated electrochemical gating: application to electroanalysis

Scientia Prof. Justin Gooding

Joana DA ROCHA

Design of pyrrolopyrimidines libraries

A/Prof. Jonathan Morris

Mengchen GE

Ionic Liquids-Based Gas Sensor

Dr Chuan Zhao

Nidup PHUNTSHO

New Applications of Indole Chemistry

A/Prof. Naresh Kumar, A/Prof Steve Colbran

William ROUESNEL

Differential modification of nanoparticles

Scientia Prof. Justin Gooding

Worawan TANTISANTISOM

Synthesis of Sanguinamide B derivatives Synthesis of Sanguinamide B derivatives: Structure-Activity Relationship and mechanism of action

A/Prof. Shelli McAlpine

Ran XU

Photochemistry of Organic Reactive Intermediates Monitored with NMR Spectroscopy

Dr Graham Ball

Jo Hyeon YOON

Studies towards the synthesis of Eupodienones

A/Prof. Jonathan Morris, A/Prof. Roger Read

Doctor of Philosophy, Chemistry (Program 1870) Candidate

Research Area

Supervisor

Moshiul ALAM

Isolation of Mo from Uranium/Aluminium target plates at ANSTO

A/Prof Marcus Cole

Iqbal AHMED

Conformational Fine-Tuning of Cyclic Peptides

Dr Luke Hunter

Abbas BARFIDOKHT

Electrochemical sensors

Scientia Prof. Justin Gooding

Murat BINGAL

Synthesis of novel anti-cancer agent

Prof. David Black, A/Prof. Naresh Kumar

Nripendra BISWAS

Novel Small Molecules for the Modulation of Bacterial Signaling Pathways

A/Prof. Naresh Kumar

Bradley BUTLER

Ionic Liquids

Dr Jason Harper

Raju CHEERLAVANCHA

Synthesis of alpha, beta, gamma-trifluoro- delta-amino acids

Dr Luke Hunter

Rui CHEN

New chemistry of reactive indoles and related heterocycles

Prof. David Black

Xin CHEN

Nanoparticles for sensing

Scientia Prof. Justin Gooding

Xiaoyu (JET) CHENG

Silicon luminescent nanoparticles

Scientia Prof. Justin Gooding

Sandra CHOY

Understanding Cooperative Catalysis with Bimetallic Rhodium(I) Complexes

Prof. Barbara Messerle

Moinul Haque CHOUDHURY

Nanoparticle modified electrodes

Scientia Prof. Justin Gooding

Kyloon CHUAH

Nanoparticle â&#x20AC;&#x201C; nanopore sensors

Scientia Prof. Justin Gooding

Swahnnyia DE ALMEIDA

Development of a Circulating MicroRNA Biosensor for the Detection Scientia Prof. Justin Gooding and Monitoring of Lung Cancer

Michelle DUNN

Carbenes in Ionic liquids

A/Prof Marcus Cole

Eleanor EIFFE

The synthesis of novel, biologically active isoflavone analogues

A/Prof. Naresh Kumar

Dominic FRANCIS

Flurous Chemistry

Dr Jason Harper, A/Prof Roger Read

Samantha FURFARI

Applications of N-Heterocyclic carbenes in inorganic chemistry

A/Prof Marcus Cole

Jiabin GAO

Organic chemistry and crystal engineering

Prof. Roger Bishop

Christopher GARDNER

Innovative utilisation of carbocation reactivity for the synthesis of biologically active flavones and isoflavones

A/Prof. Naresh Kumar

Mark GATUS

Design of Multimetallic Complexes for C-X Bond Formation

Prof. Barbara Messerle

SECTION 06 Candidate Stephen GEORGE

Research Area Ionic liquids

Supervisor Dr Jason Harper

Ryan GILBERT-WILSON

Organometallic chemistry of coordinated N2

Prof. Les Field

Joshua GINGES

Immuno-biosensors

Scientia Prof. Justin Gooding

Bakul GUPTA

Nanoparticle self-assembly

Scientia Prof. Justin Gooding

Mathew GYTON

Ring Expanded NHCs for Asymmetric Catalysis

A/Prof. Marcus Cole

Kitty HO

Antimicrobial biomaterials based on dihydroprrolones

A/Prof. Naresh Kumar

Camille HOLT

An integrated synthetic and NMR spectroscopic study of photochemical organometallic bond activation

Dr Graham Ball

Mokarrom HOSSAIN

Lignin Processing in Ionic Liquid: Electrochemical approaches towards Dissolution and Depolymerisation

Dr Leigh Aldous

Ethan HOWE

Supramolecular chemistry and self-assemble

Dr Pall Thordarson

David HVASANOV

Membrane-bound light-harvesting bioconjugates as chloroplast mimics

Dr Pall Thordarson

Amirul ISLAM

Antibacterial research developments

A/Prof. Shelli McAlpine

Scott JAMIESON

Self-assembled materials, supramolecular chemistry, application of gels in biomedicine and microscopy in chemistry

Dr Pall Thordarson

Cheng JIANG

Protein resistant electrodes for biosensing

Scientia Prof. Justin Gooding

Wei JIANG

Analysis and toxicity of heavy metals in the environment

Prof. Brynn Hibbert/ A/Prof. Grainne Moran

Asim KHAN

Oxygen reduction reaction in ionic liquids

Dr Chuan Zhao

Rima KHOURY

Multi-way models of multi-way interactions between metal ions and oligopeptides

Prof. Brynn Hibbert

Synthesis of macrocyclic peptides

A/Prof. Shelli

Seong KIM

13 15 17 19 21 23 25 27 29 31 33

41 43

McAlpine

45 47 49

Thanh LE

Systems of novel peptidomimetics

A/Prof. Naresh Kumar

Yeng LEE

Organometallic complexes for electrochemical bio-sensors

Prof. Barbara Messerle

Xunyu (Rain) LU

Nanomechanic and nanoparticle based sensors

Dr Chuan Zhao

Yong LU

Developing nanofabricated surfaces for cell biology and cell based Scientia Prof. Justin Gooding biosensors

Xun (Luke) LU

Super-resolution Fluorescence microscopy for Surface Characterisation

Scientia Prof. Justin Gooding

Adeline LUKMANTARA

Design and synthesis of novel antimicrobial agents

A/Prof. Naresh Kumar

Giulia MANCANO

Organometallic chemistry and catalysis

Prof. Barbara Messerle

Jeanette MCCONNELL

Synthesis and mechanistic evaluation of hsp90 inhibitors as anticancer agents

A/Prof. Shelli McAlpine

Alasdair McKAY

Hybrid complexes and photochemical studies by NMR

A/Prof. Marcus Cole

Alexander McSKIMMING

Inorganic chemistry

A/Prof. Stephen Colbran

Pauline MICHAELS

Arsenic sensors

Scientia Prof. Justin Gooding

Marcin MIELCZAREK

New heterocyclic compounds related to flavones

Prof. David Black

Toby MILLS

Analysis of micro-organism derived compounds for drug discovery

Prof. Brynn Hibbert

Ellaine MUNTON

Metrology in Analytical Chemistry

Prof. Brynn Hibbert

Elizabeth MURAGO

Analytical chemistry of oils

Prof. Brynn Hibbert

Ekaterina NAM

Surface-bound Light-activated Redox Enzyme Cascades

Dr Pall Thordarson

Justin NASH

Synthetic Approaches to Rulepidanol and Embellistatin

A/Prof Jonathan Morris

Thi Oanh NGUYEN

Organometallic chemistry and catalysis

Prof. Barbara Messerle

73 75 77

99 101

Maryam PARIZ

Dual sensing of cells attachment and spreading using electrochemical impedance and optical fluorescence microscopy

Scientia Prof. Justin Gooding

103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Candidate

Research Area

Supervisor

Stephen PARKER

Switchable surfaces for cell biology

Scientia Prof. Justin Gooding

Aravind RAMACHANDRAN

Electroanalytical chemistry

Scientia Prof. Justin Gooding

Dimple RANANAWARE

Medicinal chemistry

A/Prof. Shelli McAlpine

Andrew ROBINSON

Therapeutic peptides and peptide hydrogels for medical application Dr Pall Thordarson

Yael SCHTEINMAN

Porous silicon Theranostics

Scientia Prof. Justin Gooding

Venty SURYANTI

The Chemistry of N-acylisatins

A/Prof. Naresh Kumar

Safura TAUFIK

Development of an Electrochemical Biosensor based on Gold Nanoparticles for the Detection of Biomarkers

Scientia Prof. Justin Gooding

Roya TAVALLAIE

Towards the biomedical applications of gold coated magnetic Prof. Brynn Hibbert nanoparticles: Detection of serum circulating MicroRNAs as cancer markers

Ivan TAYLOR

Theoretical/bioinorganic chemistry

A/Prof. Steven Colbran

Marina TIMERBULATOVA

Organometallic chemistry

Prof. Barbara Messerle

Veronica TECCHIO

The Development of Pyrrolopyrimidines as Kinase Inhibitors

A/Prof. Jonathan Morris

Hamish TOOP

Development of Synthetic Protocols for Application in the Syntheses A/Prof. Jonathan Morris of Biologically Interesting Molecules

Andrey TREGUBOV

Rh (I) complexes anchored on carbon supports - recyclable catalysts

Prof. Barbara Messerle

Warren TRUONG

Interactions of Self-Assembling Gels with Living Systems

Dr Pall Thordarson

Hendra WAHYUDI

Development of Macrocyclic peptides into Lead structures

A/Prof. Shelli McAlpine

Yao WANG

Hsp90/Hsp70 dual inhibition study in cancer treatment and discovery of novel Hsp70 inhibitors

A/Prof. Shelli McAlpine

Alexander WEREMFO

Effectiveness of Roughened Platinum Microelectrodes in Neural Stimulation

Prof. Brynn Hibbert

Ying YANG

Light Controlled Electrochemistry on Silicon Electrodes: Application Scientia Prof. Justin Gooding to the Capture and Release of Single Cells

Fatemeh MIRNAJAFI ZADEH Investigations into quantum dots

A/Prof. John Stride

Ying ZHU

Scientia Prof. Justin Gooding

Patterning of Self-assembled Monolayers on Porous Silicon Biosensor: Toward Single Cell Monitoring

SECTION 06 Conference Presentations – Students 01

International Conference of Nanoscience and Nanotechnology, Perth, Australia, 25th – 29th February

21st Reactive Organometallic Symposium (21st ROMS) Australian National University, Canberra, 22nd June

 A. Ng, S. Ciampi, A. Magenau, M. Chockallingham, E. Luais, G. Le Saux, S.H, Ngalim, J.B. Harper, K. Gaus, J.J. Gooding.

 Ryan Gilbert-Wilson

Switchable Surfaces for Cell Biology RACI 18th Australian Electrochemistry Symposium, Curtin University, Perth, 15th April  A. Barfidokht, E. Luais, J.J. Gooding. Regain of Electrochemistry on Passivated Electrodes Decorated by Gold Nanoparticles: Thickness Dependence of the Passivating Layer  Xunyu Lu, Chuan Zhao Tuning the ionic liquid electrolytes toward efficient water splitting 10th International Society of Electrochemistry Spring Meeting, Perth, Australia, 15th – 18th April  D. Gloria, J.J. Gooding, G. Moran, D.B. Hibbert Electrochemically Fabricated Three Dimensional Nanoporous Gold Films Optimized for Surface Enhanced Raman Scattering Applications UNSW Medicinal Chemistry Forum, Sydney, Australia, 20th April  Hamish Toop Developing the Biomedical Potential of AAL(S)

Three and a Half Years of Sterically Bulky Phosphines: The Highlights Reel  Peter Jurd Carbon Dioxide Activation through Cyclometallated Complexes of Ruthenium and Iron  S. W. S. Choy and B. A. Messerle Flat Rh(I) Complexes for Hydroalkoxylation and Dihydroalkoxylation Reactions  G. Mancano, M. J. Page and B. A. Messerle Ir(I) Complex Catalysed Intra- and Inter-molecular Hydroamination  C. M. Wong, B. A. Messerle and K. Q. Vuong, Metal Catalysed Cascade C-N/ C-C Reactions for the Synthesis of Polycyclic Heterocycles

 X.Y.Cheng, P.J. Reece, K. Gaus, J.J. Gooding A new route to the efficient synthesis and functionalization of biocompatible silicon quantum dots.  B. Guan, A. Magenau, K. Gaus, P.J. Reece, J.J. Gooding Fabrication of mesoporous silicon photonic crystal particles: towards single cell sensing.  KKK Ho, Cole N, Willcox MDP, Kumar N

03 05 07 09 11 13 15 17 19 21 23 25 27 29 31 33

Novel antimicrobial coatings based on antimicrobial peptides  S.H. Ngalim, J.J. Gooding, K. Gaus, T. Bocking The cell final verdict: Cell motility in the presence of adhesive and soluble cues.  S.G. Parker, S. Ciampi, J.J. Gooding Towards Capture and Release of Circulating Tumour Cells (CTCs) Using ElectrochemicallySwitchable Surfaces

35 37 39 41 43 45 47 49 51 53 55 57 59 61 63 65

19th International Conference on Organic Synthesis (ICOS19) Melbourne, Australia, 1st – 6th July  Hamish Toop Development of Synthetic Approaches to the Total Synthesis of Naphthalene Isoquinoline Alkaloids 3rd International NanoMedicine Conference, Sydney, Australia, 2nd – 4th July

 Warren Ty Truong, Yingying Su, Filip Braet, Pall Thordarson Cell-Gel-Drug Interactions Visualised with Atomic Force Microscopy

67 69 71 73 75 77

 Y. Zhu, P.J. Reece, J.J., Gooding

Selective Surface Functionalization for Porous Silicon Biosensor: Toward SingleCell Microarrays

81 83 85 87 89 91 93

 Chen R, Cole N, Willcox MDP, Kumar N Novel antimicrobial coatings based on antimicrobial peptides

95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

20th International Symposium on Fluorine Chemistry, Kyoto, Japan, 22nd – 27th July  Dominic Francis, Jason B. Harper, Adnan I. Mohammed and Roger W. Read Progress in the Development of Fluorous Surfactants RACI NSW Organic Group OneDay Symposium  Zhiyong Wang Synthesis of fluorinated cyclic RGD peptides 244th American Chemical Society National Meeting (ACS-244) Philadelphia, PA, USA, 19th – 23rd August  Scott A. Jamieson, Michael James, Pall Thordarson Structural evolution in selfassembled gels Asian Network for Natural and Unnatural Materials II, Nanyang Technological University, Singapore, 3rd – 5th October  A. Lukmantara, Richardson D, Kumar N Synthesis and structural activity relationship studies of thiosemicarbazone based iron chelators as therapeutic agents Cancer Therapeutics CRC (CTx) Annual Postgraduate Research Symposium, Bundoora, Victoria, 16th October  Hamish Toop Developing the Biomedical Potential of AAL(S)

International Conference of Emerging Advanced Nanomaterials (ICEAN2012), Brisbane, Australia, October  F. Mirnajafi, D. Ramsey, S. MacAlpine, F. Wang, P. Reece and J.A. Stride The Investigation of Cytoxicity of Water Soluble Quantum Dots in presence of colon cancer cells Medical Chemistry Symposium, University of New South Wales, Sydney, Australia, 14th November  Worawan Tantisantisom Synthesis of Sanguinamide B derivatives: Structure-Activity Relationship and Mechanism of Action  M. Yee, Pasquier E, Black D, Kumar N Synthesis of isoflavenepropranolol hybrids as anti-tumour agents 22nd Reactive Organometallics Symposium, University of New South Wales, 19th November  A. Tregubov, K. Q. Vuong, E. Luais, J. J. Gooding and B. A. Messerle Rh(I) Complexes Bearing N,N and N,P Ligands Covalently Bound to Carbon Surfaces– Recyclable Catalysts.  M. J. Page and B. A. Messerle Bimetallic Carboxamide Complexes: Apparent Cooperativity from an Uncooperative Catalyst  M. R. D. Gatus, B. A. Messerle and G. L. Edwards Homo- and Heterobimetallic Complexes for Tandem One-Pot Reactions

2nd Annual Student Symposium in inorganic Chemistry, Australian national University, 30th November  A. Tregubov, K. Q. Vuong, E. Luais, J. J. Gooding and Barbara Messerle Rh(I) Complexes Bearing N,N and N,P Ligands Covalently Bound to Carbon Surfaces– Recyclable Catalysts 33rd Annual RACI Organic One-Day symposium, 5th December  Zhiyong Wang Synthesis of fluorinated cyclic RGD peptides  Ethan Howe, P. Thordarson Towards Switchable Anion Recognition Australian Nanotechnology Network Early Career Symposium, Melbourne, Australia, 15th – 16th December  Xunyu Lu, Chuan Zhao Carbon nanomaterials for energy conversion

SECTION 06 Conference Posters 7th International Conference on Macrocyclic and Supramolecular Chemistry (ICMSC – 7) Otago University, Dundedin, New Zealand, 29th January – 2nd February  Ethan Howe, Mohan Bhadbhade, Roger Bishop, Pall Thordarson The role of solvent effects and allosteric interactions on the cation and anion recognition of a bis-isophthalamide crown ion-pair receptor  David Hvasanov, Filip Braet, Jörg Wiedenmann, Pall Thordarson Photoinduced membrane protonpumping via polymersome as chloroplast mimics  Scott Jamieson, Michael James, Pall Thordarson Structural Evolution in SelfAssembled Gels International Conference on Nanoscience and Nanotechnology (ICONN2012), Perth, Australia, 5th February  F. Kanodarwala, JA Stride Synthesis and Characterisation of CdSe Quantum Dots 24th Lorne Cancer Conference, Lorne, Australia, February  Jeanette McConnell A Cytotoxic Macrocycle Induces Apoptosis of Colon Cancer Cells through an Hsp90-Controlled Mechanism Medicinal Chemistry Research Symposium, UNSW, February  Jeanette McConnell Allosteric modulators of hsp90

RACI Electrochemistry Division, Curtin University, Perth, Australia, 15th April  Christian Gunawan, Xunyu Lu, Bryan Suryanto, Chuan Zhao Controlled electrocrystallization of metals from protic ionic liquids  P. Michaels, S. Ciampi, E. Luais, J.J. Gooding Characterisation of DNA modified Si(111) and Si(100) using Electrochemical Impedance Spectroscopy.  E. Murago, R. Amal, D.B. Hibbert, J.J. Gooding Towards a Multiple-Analyte Sensor by use of Dispersible Modified Au@Fe3O4 Nanoelectrodes.  A. Ramachandran, M.J. Manefield, J.J. Gooding Modified Electrodes for Detecting Bacterial Activity  Bryan Suryanto, Christian Gunawan, Xunyu Lu, Chuan Zhao Exploitation of protic ionic liquids as electrolytes for electrodeposition of metals  R. Tavallaie, D.B. Hibbert, J.J. Gooding Surface Modification of Gold Coated Magnetic Nanoparticles via Electrografting of In Situ Generated Aryl Diazonium Salt Cations. th

10 International Society of Electrochemistry Spring Meeting, Perth, Australia, 15th – 18th April  A. Barfidokht, E. Luais, J.J. Gooding Regain of Electrochemistry on Passivated Electrodes Decorated by Gold Nanoparticles: Thickness Dependence of the Passivating Layer.

 X. Chen, J.J. Gooding Detection of trace Nitroaromatic Isomers Using AgNPs/bCyclodextrin Modified ITO Electrodes.

01 03 05 07 09

 M Choudrey, S. Ciampi, X. Lu, C. Zhao, J.J. Gooding

Light Addressable n-Type Silicon Photoelectrodes.

 K. Chuah, R. Amal. J.J. Gooding, I.Y. Goon, L.M.H. Lai

Ultrasensitive Electrochemical Detection of Prostate-Specific Antigen (PSA) using Gold-Coated Magnetic Nanoparticles as ‘Dispersible Electrodes’.  Christian Andre Gunawan, Xunyu Lu, Bryan Harry Rahmat Suryanto, Chuan Zhao Tuning the Electrodeposition Parameters to Yield Nanostructured Metals from Protic Ionic Liquid Electrolytes

17 19

23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53

 Xunyu Lu, Chuan Zhao Tuning the ionic liquid electrolytes toward efficient water splitting

55 57 59 61

 P. Michaels, S. Ciampi, E. Luais, J.J. Gooding Characterisation of DNA modified Si(111) and Si(100) using Electrochemical Impedance Spectroscopy.

63 65 67 69 71 73 75

 E. Murago, R. Amal, D.B. Hibbert, J.J. Gooding

Towards a Multiple-Analyte Sensor by use of Dispersible Modified Au@Fe3O4 Nanoelectrodes.

 S.G. Parker, S. Ciampi, J.J. Gooding

83 85 87 89 91 93

Towards Capture and Release of Rare Circulating Tumour Cells (CTCs) Using ElectrochemicallySwitchable Surfaces.

95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

 A. Ramachandran, M.J. Manefield, J.J. Gooding Modified Electrodes for Detecting Bacterial Activity  Bryan Harry Rahmat Suryanto, Christian Andre Gunawan, Xunyu Lu, Chuan Zhao Electrodeposition of Metals from Room Temperature Protic Ionic Liquid  R. Tavallaie, D.B. Hibbert, J.J. Gooding Surface Modification of Gold Coated Magnetic Nanoparticles via Electrografting of In Situ Generated Aryl Diazonium Salt Cations. RACI One-Day Symposium, University of Sydney, 31st May  Md. Amirul Islam Screening of Eskitis Compounds to Identify Novel Antibacterial Agent Pharmaxis Medicinal Chemistry Symposium, 1st June  Hamish Toop Developing the Biomedical Potential of AAL(S) RACI Biomolecular Chemistry Division, Sydney University, 30th June  Worawan Tantisantisom Synthesis of Sanguinamide B derivatives and its effect on type IV pili of Pseudomonas aeruginosa International Conference of Nanotechnology, Santa Clara, California, USA, June  Fatemeh Mirnajafi Highly Luminescent Quantum Dots: New Tools for Biological Applications

19th IUPAC International Conference on Organic Synthesis (ICOS – 19), Melbourne, Australia, 1st – 6th July  Ethan Howe, Mohan Bhadbhade, Pall Thordarson The role of solvent effects and allosteric interactions on the cation and anion recognition of a bis-isophthalamide crown ion-pair receptor Inorganic Conference on Organic Synthesis, Sydney, Australia, 1st – 6th July  Dominic Francis, Jason B. Harper, Adnan I. Mohammed and Roger W. Read Progress in the Development of Fluorous Surfactants 3rd International Nanomedicine Conference, Sydney, Australia, 2nd – 4th July  K. Chuah, P.J. Reece, A.P. Micolich, J.J. Gooding Solid-state Nanopore for Single Protein Molecule Detection.  B. Gupta, B. Guan, P.J. Reece, K. Gaus, J.J. Gooding Porous Silicon Photonic Crystals for the detection of infections.  X. Lu, Y. Yuan, C.S. Liu, J.J. Gooding Surface Charge Influences Cytotoxicity of SiO2 Nanoparticles in Human Hepatoma HepG2 Cells.  Warren T. Truong, Iman J. H. Pour, Galina Schevzov, Peter Gunning, Pall Thordarson The Effect of Matrix Elasticity on Cell Behaviour

19th International Conference on Organic Synthesis, Melbourne, 5th July  R. Chen, Black D, Kumar N Synthesis of New Macrocyclic Systems Based on Novel Biindolyls  Samuel Kutty, Barraud N, Pham A, Rice S, Black D, Kumar N Novel nitric oxide donors based on fimbrolides as antimicrobials Gordon Research Seminar on Organometallic Chemistry, Salve Regina University, Newport, Rhode island, USA, 7th – 13th July  Ryan Gilbert-Wilson. Sterically Bulky Phosphine Ligands on Iron and Ruthenium: Dinitrogen, Iron(I) and Ruthenium(I) Complexes 20th International Symposium on Fluorine Chemistry, Osaka, Japan, 22nd – 27th July  Dominic Francis, A. I. Mohammed, R. W. Read. Exploiting Functional Fluorous Triazoles and Tetrazoles UNSW Faculty of Science Poster Competition, 9th August  Hendra Wahyudi Derivatives of Sanguinamide B: Exploring the SAR of a Novel Macrocyclic Peptide Medicinal Chemistry Symposium, UNSW, August  Yao Wang Heat Shock Protein Inhibitors

SECTION 06 244th American Chemical Society National Meeting (ACS-244) Philadelphia, USA, 19th – 23rd August  Warren T. Truong, Pall Thordarson Therapeutic Release from within Self-Assembling Hydrogels at Physiological Conditions

 KKK Ho, Cole N, Willcox MDP, Kumar N Immobilization of antibacterial dihydropyrrol-2-ones for the prevention of bacterial infections  Md. Amirul Islam Novel Marine Natural Products Target the Gram-Positive Cell Wall th

The Southern Highlands Conference on Heterocyclic Chemistry, Moss Vale, Australia, 26th – 28th August  Ethan Howe, Roger Bishop, Pall Thordarson Supramolecular Architecture Mimicry Towards Allosteric Regulated Enzymes and Haem Proteins  Samuel Kutty, Barraud N, Pham A, Rice S, Black D, Kumar N Novel nitric oxide donors based on fimbrolides as antimicrobials  Pall Thordarson, Joshua R. Peterson, Alexander F. Mason, David Hvasanov Self-assembled Light-Driven Proton Pump Based on an Artificial Hybrid PhotosyntheticRespiratory Electron Transport Chain  V. Suryanti, Bishop R, Black D, Kumar N Self-assembly of alkyl N-acetylglyoxylic amides of varying chain length RACI Natural Products Chemistry Group One-Day Symposium, Sydney – 28th September  Eleanor Eiffe, Black D, Kumar N Biologically Active Isoflavone Analogues

25 International Conference on Organometallic Chemistry, Lisbon, Portugal – 2nd – 7th September  Matthew R. Gyton Studies of the Metal Organoamide Chemistry of a Sterically Demanding 1,3-Triazenide.

 Eden E. L. Tanner, Hon Man Yau, Anna K. Croft and Jason B. Harper Does the cation really matter? The effect of the modifying an ionic liquid cation on the outcome of an SN2 process

01 03 05 07

RACI Natural Products Group One Day Symposium, University of Sydney, 28th September

09 11 13 15

 Veronica Tecchio Pyrrolopyrimidine Libraries

17 19 21

 Sunhwa Lee Synthesis of Bicyclic Heterocyclic Libraries

23 25 27 29

 A. Tregubov, K. Q. Vuong, E. Luais, J. J. Gooding and B. A. Messerle Glassy Carbon Anchored Rh(I) Complexes Bearing N,N and N,P Ligands- Recyclable Hydroamination Catalysts International Coordination Chemistry Conference (ICCC) 40, Valencia, Spain 12th September  Carolina Gimbert-Suriñach Ferrocene-substituted Fe2hydrogen evolution catalysts, Session Lecture. st

21 IUPAC Conference on Physical Organic Chemistry, Durham, UK, 9th – 13th September  Bradley J. Butler and Jason B. Harper The effect of ionic liquids on reaction at phosphorus.  Michelle H. Dunn, Marcus L. Cole and Jason B. Harper Structure and solvent effects on the basicity of N-heterocyclic carbenes

Asian Network for Natural and Unnatural Materials II, Nanyang Technological University, Singapore, 3rd – 5th October  M. Mielczarek, Devakaram R, Kandemir H, Ma C, Black DStC, Griffith R, Lewis P, Kumar N Novel bis-indoles and tetra-indoles as bacterial RNA polymerasetranscription initiation σ factor interaction inhibitors

33 35 37 39 41 43 45 47 49 51 53 55 57

1st International Conference on Emerging Advanced Nanomaterials, The University of Queensland, Brisbane, Australia, 22nd – 25th October

59 61 63 65 67 69

 R. Chen, Cole N, Willcox MDP, Kumar N Novel antimicrobial coatings based on antimicrobial peptides

71 73 75 77 79

 F. Kanodarwala, JA Stride Synthesis and Characterisation of CdSe Quantum Dots

81 83 85 87 89

H3D Drug Discovery Symposium, Capetown, South Africa, October

 Jeanette McConnell,

Hsp90 inhibitors that modulate the immunophilins

99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

UNSW Medicinal Chemistry Symposium, Sydney, Australia, 14th November  Iqbal Ahmed Ring-expanded analogues of the anticancer peptide sansalvamide A  Raju Cheerlavancha Towards the synthesis of an a,b,gtrifluoro-d-amino acid  Eleanor Eiffe, Black D, Kumar N Synthesis of Novel, Synthesis and anti-cancer activity of 2-substituted isoflav-3-enes  Samuel Kutty, Barraud N, Pham A, Rice S, Black D, Kumar N Dual action nitric oxide donors based on fimbrolides as novel antimicrobials  Aggie Lawer Conformationally biased analogues of the antimalarial cyclic peptide pohlianin C  M. Mielczarek, Devakaram R, Kandemir H, Ma C, Black DStC, Griffith R, Lewis P, Kumar N Novel bis-indoles and tetraindoles as bacterial RNA polymerase-transcription initiation σ factor interaction inhibitors  Hamish Toop Developing the Biomedical Potential of AAL(S)  Zhiyong Wang Synthesis of fluorinated cyclic RGD peptides Drug Delivery Australia 2012, Melbourne, Australia 26th – 27th November  Warren T. Truong, Pall Thordarson Therapeutic Release from within Self-Assembling Hydrogels at Physiological Conditions

2nd Annual Student Symposium in Inorganic Chemistry, Australian National University, Canberra, 30th November  M. R. D. Gatus, K. Q. Vuong and B. A. Messerle Homo and Heterobimetallic Complexes for Tandem One-Pot Reactions  M. J. Page and B. A. Messerle Bimetallic Carboxamide Complexes: Apparent Cooperativity from an Uncooperative Catalyst  S. W. S. Choy and B. A. Messerle Flat Rh(I) Complexes for Catalysed Hydroalkoxylation and Dihydroalkoxylation Reactions Cancer Therapeutics CRC (CTx) Annual Retreat, Melbourne, 5th – 7th december  Hamish Toop Developing the Biomedical Potential of AAL(S) 33rd Annual RACI Organic One Day Symposium, 5th December  Bradley J. Butler and Jason B. Harper Structure and solvent effects on the basicity of N-heterocyclic carbenes  Dominic Francis, J. B. Harper, A. I. Mohammed, R. W. Read Progress in the Development of Functional Fluorous Surfactants  Scott Jamieson, Michael James, Tamin Darwish, Rao Yepuri, Aditya Rawal, James Hook, Pall Thordarson Structural studies of selectively deuterated self-assembled gels  Seong Jong Kim Synthetic Strategies Targeting Potent Anticancer Agent: Urukthapelstatin A

 Chun Chieh Lin A structure-activity relationship study of compounds containing sequential oxazoles and thiazoles  Alexander F. Mason, David Hvasanov, Pall Thordarson Development of a LightControlled Polymersome Nanoreactor  Veronica Tecchio Pyrrolopyrimidine Libraries  Worowan Tantisantisom Synthesis of Sanguinamide B derivatives: Structure-Activity Relationship and Mechanism of Action  Warren T. Truong, Pall Thordarson Self-assembled Hydrogels for Biomedical Applications  Ran Xu Monitoring laser irradiation intensity via the formation of organic reactive intermediates using NMR spectroscopy Australian Nanotechnology Network Early Career Symposium, RMIT, Melbourne, Australia, 15th – 16th December  F. Mirnajafi, D. Ramsey, S. MacAlpine, F. Wang, P. Reece and J. A. Stride The Investigation of Cytoxicity of Water Soluble Quantum Dots in presence of colon cancer cells  F. Kandarwala and J.A. Stride Synthesis and Characterisation of CdSe Quantum Dots

SECTION 06 01 03 05 07 09 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59 61 63 65 67 69 71 73 75 77 79 81 83 85 87 89 91 93 95 97 99 101 103

SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

SCHOOL VISITING COMMITTEE The Committee has representatives from our key stakeholder organisations – industry, government, schools and government research institutes. The terms of reference for the committee are as follows: 1. To appraise the School programs in light of the needs of the School stakeholders (industry, government, schools and research institutions). 2. To provide advice about the direction that the School should take to best enhance future interactions with our stakeholders. 3. To provide advice about the changing needs of industry, research and government organisations to best prepare the School’s graduates for future opportunities. 4. To receive and discuss the School of Chemistry’s Annual Report. 5. To aid the development of the School in any other way possible. The committee meeting with the School was very successful and we look forward to the 2013 meeting.

SECTION 07 01 03 05 07 09 11 13 15 17 19 21 23 25

External Representatives from Industry, Government and Education

27 29 31 33

Dr Attila Tottszer (Chair)

Business & Development Manager, Advanced Analytical Laboratories

Dr Christopher Armstrong

Associate Director, Science, CRC Liaison Officer, Ministry for Science and Medical Research

Dr Greg Simpson

Acting Director, CSIRO Niche Manufacturing Flagship

Dr Herma Buttner

Senior Advisor, Research Management and Science Policy â&#x20AC;&#x201C; ANSTO

Mr Roger Leigh

Senior Project Manager, Cochlear

Mr Gary Molloy

Science Teacher, St Aloysius College

Mr Jeff Stanger

Head Science Teacher, St George Girls High School

35 37 39 41 43 45 47 49 51 53 55 57 59 61 63

Ex Officio Members

65 67

Professor Barbara Messerle

Head, School of Chemistry

Scientia Professor Justin Gooding

Deputy Head, School of Chemistry

A/Prof. John Stride

Director of Research, School of Chemistry

Dr Gavin Edwards

Director of Teaching, School of Chemistry

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

OBITUARIES It was with great sadness that we farewelled three of our former friends and colleagues in 2012.

Emeritus Professor Stephen Charles Angyal The School of Chemistry records with sadness and regret the death of Professor Stephen Angyal, a distinguished former Dean and outstanding figure in Australian chemistry. Professor Angyal was 97. Although he formally retired from UNSW in 1979, he continued working with us for another two decades, maintaining a laboratory until the School of Chemistry moved to a new building in 2006. As the present Head of the School of Chemistry, Professor Barbara Messerle recalls, Professor Angyal was 90 when he published the last of his more than 200 research papers: “It was a sole-author paper, and relied on experimental work he had done. He continued to ski until he was 92.” Stephen Angyal was born in Budapest, Hungary, on 21 November 1914. His father, Dr Charles Engel, was a medical practitioner (Stephen later changed his surname to Angyal, due to anti-German sentiment in Hungary at the time). His father introduced him to literature and music as well as science. He studied science at the Royal Hungarian University of Science and completed a PhD in carbohydrate chemistry at the University for Technology and Engineering, in Budapest. With war escalating in Europe, he left Hungary and sailed for Australia from Milan on the Viminale, the last Italian ship to reach Australia before Italy entered the war. He arrived in Sydney in March, 1940. Unable to find work, he teamed up with another chemist, Dr Andrew Ungar, to establish their own company, producing chemical products from a laboratory they put together in a disused garage. The company, Andrew’s Laboratories, was successful and ultimately acquired by Johnson and Johnson. He moved to Melbourne in 1941 to join Nicholas Pty Ltd, makers of Aspro, as a research chemist and met Helga Steininger, whom he married in 1942. The company was involved in producing essential wartime supplies for Australian troops in New Guinea.

SECTION 08 01 03 05 07 09 11 13 15 17 19 21

Returning to Sydney in 1946, he took up a post at the

well beyond any norm and a truly major contribution to

University of Sydney as a chemistry lecturer, despite

the work and life of the University”).

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having given only one public lecture in English. Here he taught and began his research into inositols – a family of simple carbohydrates. In 1950, he gave an address to the Sydney Chemical Society and in the audience was Alexander Todd, then a visiting professor at Sydney University. Todd was impressed and invited Angyal to

Stephen Angyal was elected a Fellow of the Australian Academy of Science in 1962 and received the first

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Doctorate of Science (DSc) awarded by UNSW in 1964.

From 1970 to 1979, he served as Dean of the Faculty of

Science.

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spend his study leave in Todd’s laboratory at Cambridge

In 1977 he was made an Officer of the Order of the

University. Todd later won the Nobel Prize in Chemistry,

British Empire (OBE).

He travelled widely to conferences and spent further

in 1957. Another researcher in the lab at the time, Har Gobind Khorana, also won a Nobel in 1968.

periods working at the University of California at

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In early 1953, Angyal joined the fledgling NSW

Berkeley, the Natural Products Institute at Gif-sur-Yvette

University of Technology (now UNSW) as an Associate

near Paris, and the University of Grenoble, Oxford

Professor of organic chemistry.

University, Imperial College London, and the ETH in

“Their School of Chemistry was taken over from the Sydney Technical College and I knew it well,” Angyal recalled in a memoir. “It was built up by the energetic Dr R. K. Murphy, who recruited good people. Chemistry

Zürich. He is credited with making a major contribution

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to Australian chemistry, not only through his research but

also in attracting leading chemists to travel to Australia

to lecture and take part in conferences.

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was at university level even then and it was probably

He was a keen swimmer and skier, and had a wide

the strongest element of the new university. Amongst

range of cultural interests, especially music. He was

the first professors appointed were those of chemistry,

a staunch admirer and supporter of the Australia

chemical engineering and metallurgy; the institution

Ensemble (resident at UNSW) since its formation in

was sometimes facetiously referred to as ‘University of

1980. The Ensemble dedicated a performance of the

Chemistry’.

Tchaikovsky Piano Trio to his memory.

In 1960 he was appointed to a new Chair as Professor

During the International Year of Chemistry in 2011,

of Organic Chemistry. Helga Angyal became involved

Chemistry in Australia, published by the Royal Australian

in university affairs as well through her fund-raising

Chemical Institute, named him as one of the “living

activities as a founding member of the U Committee

luminaries of Australian chemistry”. In an interview at the

(in 1999, the university’s 50th anniversary, Helga was

time, he said his greatest achievement was “to put the

awarded the Jubilee Medallion “for dedicated service

chemistry of carbohydrates on a firm ground”.

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SCHOOL OF CHEMISTRY ANNUAL REPORT 2012

Asked to choose a famous historical figure to dine with, he said: W. Somerset Maugham. In my young days I

Professor Peter Steele Clezy

read most of his books and learnt much of my English

Peter Clezy was born in Melbourne on 21 January

from him.”

1930 and at the age of 10 moved with his family to Hobart (his father was a bank clerk). He matriculated

Asked what advice he would offer to chemistry

from Hobart High School where he was a Class

professionals just starting out, he said: “There are many

Captain and Head Prefect and went to the University

ways to use your knowledge. Good chemists are wanted

of Tasmania in 1947, with the intention of completing a

in education and industry; for legal advice and for

medical degree. In those days, a first year start could

research. Look before you decide.”

be made in Hobart, but the medical degree had to be

The present Dean of the Faculty of Science, Professor

completed in Melbourne. Peter did well in Chemistry,

Merlin Crossley, paid tribute to Professor Angyal:

Botany and Physics but failed Zoology, so repeated

“Stephen was one of the giants of the age when new

the year, as that was the requirement for entry into

scientific universities like UNSW were established. He

Medicine. In the repeat year, organic chemistry became

set the foundations of excellence and continued to

a major part of the chemistry course and Peter was

support the School of Chemistry and university long after

completely hooked. He therefore stayed in Hobart and

his formal retirement. We are very fortunate to have had

completed his BSc in 1950. He did Honours in 1951

people of his calibre as role models and supporters.”

and worked with Dr John Polya on an “Investigation of the Microchemical Constituents of the Tasmanian

**Thanks to David Black, who assisted in compiling this

Fern Tmesipterus” and graduated with Second Class

report, most of which is extracted from Stephen Angyal’s

Honours. He continued on to PhD studies with Dr Ralph

own memoir.

Bick, who had recently returned from Cambridge as a

On a sad endnote, Stephen’s wife of many years, Helga, th

passed away peacefully in her sleep on 30 November 2012.

new lecturer. He completed his PhD in 1955 (graduating in 1956) and his thesis was titled “Studies in the Field of Bisbenzylisoquinoline Alkaloids”. Although he was aiming for an academic career, he had no desire to travel overseas, and accepted a position as Teaching Fellow at the newly founded University of Technology in Sydney. It was there that he became closely associated with (now Emeritus Professor) Ken Cavill, and after a second year as Teaching Fellow, he took up a research position in the Biochemistry Department of the Royal North Shore Hospital. This was to be a defining time in his chemical career, as he worked together with Dr David Morell and under the direction of Dr Rudi Lemberg, on the chemistry of the porphyrins, centrally important molecules of life. This was to become Peter’s research field for the rest of his career. In 1960 he moved to a lectureship at the NSW University of Technology, in the process declining a similar offer from the University of Melbourne. He was promoted to Senior Lecturer in 1964 at what was then the University of New South Wales, and became Associate Professor in 1973. He was awarded a DSc by UNSW in 1983 and promoted to a Personal Chair in 1985. Until his retirement in 1994, Peter developed

SECTION 08 a superb research record with the help of a relatively small but unusually talented group of postgraduate and postdoctoral associates, and became a world leader in porphyrin chemistry. He developed new synthetic 01

approaches to porphyrins with unique substitution

patterns, and his advice was widely sought by porphyrin

chemists worldwide. Peter eventually travelled overseas

for a year of study leave in 1967 with Dr John Cornforth

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(now Sir John Cornforth, Nobel Laureate) at the Milstead

Laboratory of the Shell Company in Kent.

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Peter’s entire career was marked by complete honesty

and integrity in everything he did. He was a great

teacher, both to undergraduate and postgraduate

students, but shunned any thought of seeking rewards

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for this. His publications ran to a total of 129, including

a superb series of 71 papers under the generic title

“The Chemistry of Pyrrolic Compounds”. One could not

have wished for a better colleague, as Peter contributed

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unstintingly in every possible way for the good of his

colleagues, the chemistry school and the university. He

was totally reliable and dedicated at all times.

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Peter was a quiet and self-contained person but with

great inner passion and a delightful sense of humour.

In 1955 he married Charlotte Hope (universally known

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as “Chip” as in “off the old block”) and had two daughters and a son. His father was a keen sportsman and a member of the Melbourne Cricket Club, and he put Peter down for membership at an early age. Peter became a member in 1956 and sought every opportunity to see a cricket test match or watch his beloved Melbourne Demons play Australian Rules football. Peter was himself very talented in both sports and actively participated throughout his younger years.

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Teresa Ellis

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Teresa began with the School of Chemistry as a tea-lady

for the academic staff in 1985, and eventually became a

laboratory assistant. Teresa always had a cheery “hello

luv” for everyone and managed to make all around her

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see a brighter side of life. She retired from the School of

Chemistry in February 2011.

In later years, on Monday mornings, his colleagues

enjoyed many amusing conversations, suitably coloured

Teresa lost her long battle with ovarian cancer on

by the events of the weekend.

22nd October 2012. Her many friends and colleagues

attended the service and will miss her always.

Peter Clezy will be remembered with great affection and respect not only by his colleagues, but also by

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many chemistry students at UNSW. He was indeed a

wonderful man!

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Produced by the School of Chemistry The University of New South Wales UNSW SYDNEY NSW 2052 AUSTRALIA T +61 2 9385 4683 F + 61 2 9662 1697 E chemistry@unsw.edu.au W www.chem.unsw.edu.au REPORT EDITOR Jodee Anning, School of Chemistry UNSW PHOTOGRAPHY LMD, Gasbag Studios, Svetislav Videnovik, Steve Preece and School of Chemistry DESIGN / PRINTING PRINT POST PLUS (P3) COPYRIGHT ÂŠ 2013 UNSW School of Chemistry All information produced in the School of Chemistry Annual Report, was correct at time of printing. UNSW reserves the right to change and update any details contained within this book. CRICOS PROVIDER CODE 00098G REF 54314