UK Oncology Assets BIO Convention June 2017
San Diego, CA
To connect with any of the companies listed here, please contact:
Kathryne.Kirk@mobile.trade.gov.uk & Torrey.Ah-Tye@mobile.trade.gov.uk
Contents
Cancer Research Technology (CRT)
3
Medical Research Council Technology (MRC-T)
4
Immunotherapy
5
T-Cell Therapies
6
Antibody Therapeutics
7
Small Molecule Inhibitors
9
Gene Therapy
10
Drug Discovery in Rare & Orphan Indications
11
Clinical Oncology: Medical Devices and Technology
13
CANCER RESEARCH TECHNOLOGY
Name
About
SMALL MOLECULES
K e y w o rd s : enzyme / checkpoint inhibitors, oncology targets, cancer targets, pre-clinical, drug discovery platforms, stem cells
CONTACT: ANDREA SCHIEVELLA, HEAD OF BUSINESS DEVELOPMENT
http:// www.cancertechnology.co.uk/
CONTACT: ANDREA SCHIEVELLA, HEAD OF BUSINESS DEVELOPMENT
ENABLING TECHNOLOGY OPPORTUNITIES
CONTACT: ANDREA SCHIEVELLA, HEAD OF BUSINESS DEVELOPMENT
DIAGNOSTICS OPPORTUNITIES
2. First in class IKK alpha selective inhibitors 3. Inhibitors of autotoxin 4. Novel dual inhibitors of FLT3 & Aurora Kinases
1. Optimam mammography image database and viewing software 2. Imaging agent for prostate and glioma tumor detection
Description: Part of Cancer Research UK, CRT develops and commercializes new discoveries in cancer research as ‘the meeting point between academia and industry.’
CONTACT: ANDREA SCHIEVELLA, HEAD OF BUSINESS DEVELOPMENT
1. Chk2 inhibitor program
1. CEA antibodies 2. vß6-binding peptides for tumor Keywords: antibodies, tumor targeting targeting 3. MUC1 peptides, trap therapy, angiogenesis, T- 4. S100A4 neutralizing antibody cell receptors 5. IGF2-Trap therapy 6. vß6 antagonistic antibodies Description: Part of Cancer 7. TACE antibody Research UK, CRT develops and 8. p53 TCR mimic antibody commercializes new discoveries in 9. CLEC14a cancer research as ‘the meeting point 10. Jagged1 Monoclonal Antibody between academia and industry.’ 11. LMP2-TCR 12. CXCL12 13. CCR4 14. Anti-CD55 Antibodies Keywords: imaging agents, prostate cancer, glioma, tumor detection, radiolabelling, FRET- FILM, leukemia cell assay, kinase substrate identification
CONTACT: ANDREA SCHIEVELLA, HEAD OF BUSINESS DEVELOPMENT
MEDICAL DEVICES
Description: Part of Cancer Research UK, CRT develops and commercializes new discoveries in cancer research as ‘the meeting point between academia and industry.’
BIOLOGICAL THERAPEUTICS
Assets
Keywords: biological fluid filtration, cancer diagnostics, high intensity focused ultrasound, sonic ablation
3. RALA
1. Biological fluid filtration device, for capture of material from biological fluids, such as tumor cells from urine, patent pending.
Description: Part of Cancer Research UK, CRT develops and commercializes new discoveries in cancer research as ‘the meeting point between academia and industry.’ Keywords: diagnostics, screening, breast cancer risk, imaging validation, ovarian cancer predictive, lung cancer, pancreatic cancer, prostate cancer Description: Part of Cancer Research UK, CRT develops and commercializes new discoveries in cancer research as ‘the meeting point between academia and industry.’
1. vß6 binding peptides for imaging 2. MCM Lung
MRC TECHNOLOGY
Name
About
ONCOLOGY
Keywords: immuno-oncology, immunology, oncology, antibodies, neoplasm, signaling molecule modulator, Millipore kinase panel, autophagy
CONTACT:
DR JOHN KELLY, ASSOCIATE DIRECTOR OF BUSINESS DEVELOPMENT
Genetic markers for therapy in renal cell carcinoma (RCC) Provides stratification of renal cell carcinoma to improve patient outcome and therapy options.
Description: MRC Technology is the tech transfer arm of the Medical Research Council, an independent medical research charity committed to innovation in multiple fields.
3. PAICS Inhibitors for outlicensing
Keywords: cancer, oncology, kidney, renal cell carcinoma, tyrosine kinase inhibitors, diagnostic, gene profile, sunitinib, response
CONTACT: DR JOHN KELLY, ASSOCIATE DIRECTOR OF BUSINESS DEVELOPMENT
2. ULK Inhibitors for outlicensing
CANCER DIAGNOSTICS
CONTACT: DR JOHN KELLY, ASSOCIATE DIRECTOR OF BUSINESS DEVELOPMENT
1. MNK Inhibitors for outlicensing
Description: MRC Technology is the tech transfer arm of the Medical Research Council, an independent medical research charity committed to innovation in multiple fields.
ONCOLOGY THERAPEUTICS
Assets
Keywords: cancer, oncology, therapeutic, pro-drug, therapeutic, palladium activated, endotoxaemia, ang2, angiopoietin, sepsis retinopathy, Src, abl, breast cancer, ovarian cancer
1. Targeting cancer therapeutics with palladium-activated compounds 2. Ang2 specific biotherapeutic
Description: MRC Technology is the tech transfer arm of the Medical Research Council, an independent medical research charity committed to innovation in multiple fields.
3. Specific Src inhibitor
IMMUNOTHERAPY
Name CANCER IMMUNOTHERAPY CONTACT: STEPHEN SHUTTLEWORTH, CHIEF SCIENTIFIC OFFICER
www.karustherapeutics.com/
ONCOLOGY, FIBROSIS & AUTOIMMUNE
redxpharma.com
T CELL RECEPTOR-BASED THERAPIES CONTACT: EVA-LOTTA ALLAN, CHIEF BUSINESS OFFICER
Description: Clinic stage biopharma company developing oral small molecules for the treatment of solid tumors and haematological cancer. These molecules are in clinical trials at the MD Anderson Cancer Center in Houston, Texas.
1. Porcupine antagonists – preclinical development (oncology and fibrosis) 2. BTK reversible inhibitors – preclinical development (oncology and autoimmune) 3. Pan-RAF antagonists – lead optimization (oncology) 4. MDR gram negative infections – lead optimization
Keywords: immuno-oncology, oncology, cancer, checkpoint, antibody, oncolytic, oncolytic virus, T-cell, gene therapy, cytokine, delivery, shRNA, immunology
CONTACT: JOHN BEADLE, CHIEF EXECUTIVE OFFICER
1. KA2237 is a first-in-class dual-PI3Kp110β/δ inhibitor with broad potential to treat hematological and solid tumors, including aggressive β/δ expressing Non-Hodgkin Lymphomas such as Diffuse Large B-Cell Lymphoma and Mantle Cell Lymphoma, as well as ibrutinib resistant blood cancers. 2. KA2507 is a highly-selective, oral, small molecule HDAC6 inhibitor that has potential in the treatment of liquid tumors such as multiple myeloma and lymphoma, and PD-L1-expressing tumors such as melanoma by acting as a cancer immunotherapeutic.
1. Enadenotucirev a systemically available oncolytic virus currently in combination studies with both checkpoint and chemotherapeutic agents 2. NG-347: directs tumor cells to Description: Clinical stage Oxford based produce membrane bound CD80 and company focused on immuno-oncology. secrete interferon alpha and MIP1 alpha Oncolytic viruses and cancer specific 3. NG-350: directs tumor cells to secrete immuno-gene-therapy. a full length antibody (mAb identity currently undisclosed) 4. NG-600 series: direct tumor cells to secrete BITes directed against stromal targets such as fibroblasts
ONCOLYTIC IMMUNOTHERAPY
Keywords: Cancer, Targeted Therapy, Cancer Immunotherapy, Tumor Microenvironment, TME, Small Molecule, Treg Cell, MDSC, Immunomodulator, Immune Checkpoint, B-cell Lymphoma, PI3K, PI3 Kinase, HDAC6, p110b, p110d, Solid Tumor, Epithelial Tumor, PD-L1
Description : Redx is engaged in the discovery and development of novel small molecule therapeutics targeting high unmet needs in oncology, fibrotic and autoimmune diseases.
www.immunocore.com/
Assets
Keywords : small molecules, oncology, immune-oncology, tumors, cancer inhibitors, fibrosis, IPF, kidney fibrosis, diabetic nephropathy, antibacterial, multi-drug resistant bacteria, autoimmune
CONTACT: NICHOLAS ADAMS, CHIEF BUSINESS OFFICER
psioxus.com
About
Keywords: ImmTAC, T cell receptor, immunology, oncology, HLA targets, malignant cutaneous melanoma, ocular melanoma, glioblastoma Description: Clinical-stage company focused on innovative therapies called ImmTACs, based on its proprietary T cell receptor technology.
1. IMCgp100, completed Phase II for malignant cutaneous and ocular melanoma 2. Additional Assets undisclosed,
T-CELL THERAPIES
Name
About
T-CELL THERAPIES CONTACT: HELEN TAYTON-MARTIN, CHIEF BUSINESS OFFICER
Assets
Keywords: T-cell therapy, Peptide Engineering, Immune System, TCR Therapies
1. T-cell therapy targeting NYESO peptide across multiple cancer types, Phase 1/2 trials
Description: Pre-clinical company focused on proprietary SPEAR (Specific Peptide Engineered Affinity Receptor) T-cell engineering platform.
2. MAGE-A10 T-cell therapy
adaptimmune.com
3. AFP TCR therapeutic targeted to a peptide associated with hepatocellular carcinoma 4. MAGE-A4 TCR SPEAR T-cell therapy
T-CELL THERAPIES
Keywords: immuno-oncology, oncology, cancer, T-cell therapies, hematological malignancies, solid tumors
CONTACT: CHRIS WILLIAMS, DIRECTOR OF BUSINESS DEVELOPMENT www.autolus.com
Description: Autolus is a leader in T-cell programming and manufacturing technology and has established a development-stage pipeline of products for the treatment of hematological malignancies and solid tumors.
For questions about Autolus assets, please connect with Chris Williams, Director of Business Development at contact@autolus.com
ANTIBODY THERAPEUTICS
MONOCLONAL ANTIBODIES
Keywords : oncology, immune-oncology, monoclonal antibodies, drug discovery, intestinal bowel disease, scleroderma.
CONTACT: STEVE HOLMES, CHIEF OPERATING OFFICER
1. CBS001: Preclinical antibody to a TNFSF member for IBD 2. CBS004: Preclinical antiBDCA-2 antibody for scleroderma 3. CBS007: Tumor specific monoclonal antibody to a checkpoint inhibitor target
Description : Capella Bioscience uses novel technologies to develop monoclonal antibodies to innovative therapeutic targets in oncology and autoimmune disease.
cap
ellabioscience.com
ANTIBODY-BASED THERAPIES
Keywords: oncology, Immunooncology, antibody drug conjugates (ADCs), checkpoint inhibitors, novel antigen targets, solid tumors
CONTACT: CHRISTIAN ROHLFF, CHIEF EXECUTIVE OFFICER
Description: Clinical-stage biotechnology company developing innovative antibody based therapies for cancer. MEN1112 (OBT357) is an ADCC www.oxford antibody for AML in phase I testing. MEN1309 (OBT076), an ADC for NHL, biotherapeutics.com triple-negative breast, and other solid tumors, is on track to enter first-in-human trials in mid-2017. ANTI-GLYCAN THERAPEUTIC
1. Proteomics based target discovery platform for identifying novel checkpoint inhibitors and cancer antigens
MONOCLONAL ANTIBODIES
Keywords: immunotherapy, monoclonal antibodies, oncology, solid cancers, pre- clinical, immunogenic cell death, bispecific antibodies, ADC, CAR-T
CONTACT: DR TINA PARSONS, BUSINESS MANAGER
Description: NUTAC develops therapeutic monoclonal antibodies to tumor associated glycans.
.uk/nutac/
www.nottingham.ac
BISPECIFIC ANTIBODIES CONTACT: DR JANE DANCER, CHIEF BUSINESS OFFICER www.f-star.com/
ANTIBODY THERAPEUTICS CONTACT: DANIEL BARTON, DIRECTOR, INVESTOR RELATIONS
www.biosceptre.com/
2. Novel Immuno-oncology programs available for licensing/partnering 3. Pre-clinical ADC assets available for licensing/partnering
1. FG129 pre-clinical monoclonal antibody, recognizes a Sialyl-diLewisa 2. FG88 pre-clinical monoclonal antibody, recognizes Lewisa,c,x 3. FG27 pre-clinical monoclonal antibody 4. Platform and additional early stage pre-clinical assets undisclosed, available for licensing
Keywords: bispecific antibodies, immuno-oncology, Modular Antibody Technology™, Fcab™, mAb²™, cytokines
1. Bispecific antibody programmes in immuno-oncology
Description: Clinical-stage biopharmaceutical company developing bispecific antibody immuno-oncology products selected for their potential to transform the treatment of cancer.
2. Modular Antibody Technology platform for strategic collaborations on bispecific antibodies and Fcbased formats
Keywords: basal cell carcinoma, nfP2X7, monoclonal (domain) antibody, peptide vaccine colorectal, breast, prostate, lung, cancer, solid tumor, oncology, cancer, immuno-oncology Description: Biosceptre is UK based biotech with three products in the clinical pipeline, all targeting a novel oncolog y target - nfP2X7, a form of P2X7 that is expressed only in the tumour microenvironment, and which occurs in a broad range of cancers.
1. BIL03s is our systemic monoclonal (domain) antibody – for solid tumors entering Phase 1 in Q3 2017 2. BIL06v is our peptide vaccine for solid tumors entering Phase 1 in Q3 2017 3. BIL010t is our topical Antibody treatment for locally advanced Basal Cell Carcinoma (laBCC) - Phase 2 in Q3 2017
ANTIBODY THERAPEUTICS, CONT.
MULTISPECIFIC ANTIBODIES CONTACT: DR PEDRO DE NORONHA PISSARRA, CHIEF EXECUTIVE OFFICER www.biotecnol.com/
FUSION ANTIBODIES CONTACT: DR PAUL KERR, MANAGING DIRECTOR
https://www.fusionantibodies.com/
ANTIBODY THERAPEUTICS CONTACT: DR. TOBY RICHARDSON, ASSOCIATE DIRECTOR, BUSINESS DEVELOPMENT www.icr.ac.u k/
MONOCLONAL ANTIBODIES CONTACT: DR STEVE DOWD, DIRECTOR, BUSINESS DEVELOPMENT kymab.com/
MONOCLONAL ANTIBODY THERAPEUTICS
CONTACT: DR SALMAN RAHMAN, CEO
vasgen.co.uk
Keywords: basal cell carcinoma, nfP2X7, monoclonal (domain) antibody, peptide vaccine Description: Immuno-oncology company developing multispecific Tcell engagers and immune-modulators which locally counter potential blocking signals on T and NK cells.
Keywords: immuno-oncology, monoclonal antibodies, colorectal cancer, breast cancer, lung cancer, prostate cancer, glioblastoma
1. Tb535, pan-cancer T-cell engager for 5T4 expressing tumors, pre-clinical 2. Tb434, pan-cancer T-cell engager against Triple Negative Breast Cancer, pre-clinical 3. Tb232, novel anti-HER2 T-cell engager for mutated and resistant metastatic breast cancers, pre-clinical 4. Various early-stage programs 1. Fsn0503h, an anti-Cathepsin S antibody, against colorectal, breast, prostate, glioblastoma and other cancers (preclinical as monotherapy and in combination)
Description: Antibody humanization company with a preclinical-stage pipeline of antibodies through its Fusion 2. Fsn1006 dual specific IgG1 Therapeutics division. monoclonal antibody which binds AREG and HB-EGF, against colon, breast, lung and other cancers (pre-clinical) Keywords: rat monoclonal antibodies, Her2, Neu, EGFR, CerbB2. Description: A University of London and Royal Marsden hospital affiliated research charity which ranks in the Top 4 institutes for cancer research worldwide.
Keywords: monoclonal antibodies, immunology, oncology, drug discovery, mouse models, anemia, chronic pain, dyslipidemia, infectious diseases, Ebola Description: Preclinical- stage company focusing on development of monoclonal antibody drugs in immuno- oncology, immunology, and opportunistic spaces. Keywords: ADAMs, ADAM15, Metzincin, AMD, cancer, AbIMP, metalloprotease, anti- angiogenesis Description: Pre-clinical-stage company developing first-in- class monoclonal antibody therapies for unmet needs in ophthalmology and oncology medicine.
1. 1. Monoclonal antibodies against EGFR, thorough preclinical characterization for all, one has completed Phase 1B trials. 2. Monoclonal antibodies against Cerb-B2, extensive preclinical evaluation completed.
1. KY1005, Anti-OX40L, for immunology 2. KY1006, Anti-LIGHT, for immunology 3. Numerous other discovery-stage assets for oncology, anemia, chronic pain, Ebola and others 1. First-in-class monoclonal antibody for anti-angiogenesis /anti-tumour therapy in wet AMD, prostate cancer, breast cancer & solid tumours: lead identification. 2. AbIMPÂŽ platform: Targetenabling antibody platform for selective inhibition of intractable metzincin proteases: proof-ofconcept
BICYCLIC PEPTIDES
Keywords: bicyclic peptides, oncology, CONTACT: research collaboration, drug discovery KEVIN LEE, CHIEF EXECUTIVE OFFICER Description: R&D stage company www.bicyclethe backed by Atlas Ventures and Novartis rapeutics.com/ Venture funding, among others, exploring the therapeutic possibilities of bicyclic peptides.
1. BT1718 bicyclic oncologic agent (pre-clinical) 2. Research collaboration opportunities to apply proprietary platform to targets from partners
SMALL MOLECULE INHIBITORS
Name
About
ONCOLOGY & WOMEN’ S HEALTH
CONTACT: DR JOHN NORMANTON, CHIEF EXECUTIVE OFFICER
w.estryx.com/
Keywords: oncology, women’s health, hormone-dependent cancer, Dual Aromatase-Sulfatase Inhibitor, steroid sulfatase inhibition, multi-targeting therapeutic, orally-available, hormone replacement therapy, contraception
Description: A new drug development company focused on the design and development of small molecule ww therapeutics in oncology and women’s health.
SMALL MOLECULE THERAPEUTICS
Assets 1. STX140, an orally active, multi-targeting, orally- available therapeutic for multiple oncology indications, acting as an irreversible steroid sulfatase inhibitor (STSi); a carbonic anhydrase IX (CAIX) inhibitor; a microtubule disruptor; and an angiogenesis inhibitor. 2. Orally active Dual Aromatase-Sulfatase Inhibitor (DASI) for estrogen- dependent tumors 3. DnE2MATE for oral contraception & HRT
Keywords: novel small molecule inhibitors, enzyme inhibitors, folate receptor, phase 1, hypoxic tumors, AML, colorectal cancer, metastasis, invasion, lung cancer, hepatoma, head and neck tumors, breast cancer, ovarian cancer, colorectal cancer.
1. BTG945 (ONX-0801, BGC945): First-in-class α-folate receptor targeted ovarian cancer therapeutic and companion diagnostic; phase 1 results presented at ASCO 2017 (Abstract CONTACT: #2503). 2. FLT3/AURORA: potent and orally bioavailable DR. TOBY RICHARDSON, clinic-ready dual FLT3/Aurora kinase inhibitor for ASSOCIATE DIRECTOR OF AML (clinic-ready). BUSINESS DEVELOPMENT Description: A University of London and 3. LOX: for the treatment of breast, ovarian and Royal Marsden hospital affiliated research colorectal cancer, inhibitors should prevent charity which ranks in the Top 4 institutes tumour progression and metastases (late lead for cancer research worldwide. optimization). ww 4. GDEPT: Gene-directed enzyme pro- drug w.icr.ac.uk/ therapy, for treatment of lung, colorectal, head and neck tumors, as well as hepatoma (pre-clinical).
CANCER: GENERAL ONCOLOGY
CONTACT: ADAM STOTEN, HEAD OF TECHNOLOGY TRANSFER https://innovation.ox.ac.uk/
1. A novel and specific biomarker on the cell surface of Ewing’s Sarcoma tumors that can be used as a diagnostic or therapeutic target. 2. STX140 - an orally active multi-targeting drug for multiple oncology indications, acting as an irreversible steroid Description: Isis Innovation is a wholly- sulfatase inhibitor (STSi); a carbonic anhydrase owned subsidiary of the University of IX (CAIX) inhibitor; a microtubule disruptor; and Oxford, managing technology transfer and an angiogenesis inhibitor. academic consulting for Oxford, and 3. Orally active Dual Aromatase- Sulfatase providing consultancy services to clients inhibitors (DASI) for treatment of estrogenaround the world. dependent cancers. Keywords: biomarker, Ewings sarcoma, oncology, Therapeutic, STSi, CAIX, microtubule, angiogenesis, aromatase, 17ß-estradiol, DASI
DRUG DEVELOPMENT FOR MULTIPLE MYELOMA CONTACT: JOHN MARCH, CEO
Keywords: Drug development, Multiple Myeloma, Cilengitide-based therapy
1. Cilengitide-based therapy for multiple myeloma
Description: Iceni Pharmaceuticals 2. Novel formulation and delivery technologies, develops cancer therapies, specializing in currently at pre-clinical in vivo optimization repurposing and reformulating existing drugs for new indications. 3. Clengitide in combination with proteasome inhibitors for the treatment of breast cancer
http://www.icenipharma.com/
SMALL MOLECULE INHIBITORS, CONT. ONCOLOGY & AUTOIMMUNE CONTACT: DR TIM MITCHELL, CHIEF EXECUTIVE OFFICER
Description: Drug discovery and development company, with a focus on targeted small molecule therapeutics for cancer and autoimmune diseases.
www.sareum.com
UBIQUITIN PATHWAY MODULATION
CONTACT: PAUL WALLACE, CHIEF BUSINESS OFFICER
iontherapeutics.com
Keywords: Ubiquitin, small molecule drugs, targeting de-ubiquitylating enzymes (DUBs), novel therapeutics Description: Drug discovery and development company, with a focus on targeted small molecule therapeutics for deubiquitylating enzymes.
1. Aurora+FLT3 kinases inhibitor, targeting AML and ALL (preclinical) 2. TYK2 kinase inhibitor, targeting T-ALL (lead opt)
1. USP7 – DUB with immuneoncology link and an established anti-cancer target 2. Inhibitors of selected DUBs involved in DDR 3. Additional DUB oncology targets
www.miss
BIOMARKER OPPORTUNITIES CONTACT: DR. TOBY RICHARDSON, ASSOCIATE DIRECTOR OF BUSINESS DEVELOPMENT www.icr. ac.uk/
Keywords: oncology, lung cancer, pancreatic cancer, AML, lymphoma, neuroblastoma, JAK family, psoriasis, rheumatoid arthritis, RA, multiple sclerosis, MS, lupus, inflammatory bowel disease, IBD
Keywords: MPS1, ATR, biomarker, stratification, diagnostic, SMARCB1deficient, Sarcoma, PDGFRα, FGFR1, resistance.
1. MPS1 inhibitor Resistance Diagnostic: based on point mutations that confer resistance against multiple inhibitors.
Description: A University of London and Royal Marsden hospital affiliated research charity which ranks in the Top 4 institutes for cancer research worldwide.
2. ATR Inhibitor Sensitivity Diagnostic; method of identifying cancer patients likely to be responsive to treatment with an ATR inhibitor. 3. Treatment of SMARCB1deficient Sarcomas: basis for dual targeting with inhibitors towards PDGFRα and FGFR1.
GENE THERAPY
Name
About
GENE SILENCING
Keywords: genetic medicine, oncology,
Assets VAL 101 GeneICE Bcl-2 inhibitor,
GeneICE, Bcl-2 inhibition, prostate cancer, against prostate, ovarian, and CONTACT: breast cancer, ovarian cancer, pancreatic cancers MARK TREHARNE, endometriosis, cancer screening, lung CORPORATE DEVELOPMENT MANAGER cancer VAL 201, against prostate cancer
www.valirx.com/
(with potential in breast and ovarian Description: Clinical-stage company cancers, endometriosis), Phase I developing cancer therapies and associated biomarkers, with sub-focuses in neurology VAL 401, against lung cancer, preand inflammatory disease. clinical
RNA-BASED THERAPEUTICS
Keywords: genetic medicine, pancreatic
cancer, head and neck cancer, lung CONTACT: disease, pulmonary hypertension, RNA interference, gene silencing, messenger LUCIO IANNONE, RESEARCH & DEVELOPMENT MANAGER RNA, RNAi, mRNA
www.silence-therapeutics.com/
LipTideTM – a new, custombuilt vector to deliver your gene therapy CONTACT: DR ALAN WALKER, DIRECTOR BUSINESS DEVELOPMENT
www.LipTide.com
Description: Clinical-stage company which utilizes RNA interference (RNAi) and mRNA technology to develop therapies which ‘silence’ disease-causing gene expression.
K eyw ords : gene therapy, siRNA, gene editing, DNA, RNA vaccine, delivery, viral, liptide, liposome, crispr, CAS9, saRNA, mRNA, DNA, plasmid
1. Atu027, against pancreatic cancer, Phase II 2. Atu027, against head and neck cancer, Phase I 3. Atu111, against lung indications, pre-clinical
1. LipTideTM can be modified to target different cell types and does not accumulate in the liver.
D e scrip tio n : The greatest challenge 2. LipTideTM has been facing researchers has been the inability to deliver nucleic acids into target cells with efficiency, specificity and minimal side effects and this is holding back the true potential of gene therapy. Nanogenics is proud to introduce LipTideTM; an exciting custom-built delivery vehicle for all gene therapy. Every aspect of LipTideTM can be modified to target different cell types and deliver different payloads. Nanogenics are looking to out-licence LipTideTM to help translate your gene therapy into potential clinical programs.
successfully administered in vivo by nebulisation, systemic delivery (i.v.) and by convectionenhanced delivery to the brain. 3. LipTideTM delivers for all nucleic acid payloads including siRNA, saRNA, mRNA, DNA and even artificial chromosomes.
DRUG DISCOVERY IN RARE AND ORPHAN INDICATIONS
Name
GLIOBLASTOMA CONTACT: DR ANDY MORLEY, CHIEF SCIENTIFIC OFFICER
Keywords: oncology, Glioblastoma, research collaboration, drug discovery, small molecule, brain penetrant
Assets 1. Proprietary novel approach for the treatment of Glioblastoma Multiforme and other cancer indications. Pre-clinical.
Description: Opal Oncology seek out commercially viable anti-cancer therapies in high-impact orphan cancer indications which have been failed by existing therapies.
www.opalonc.com/
ORPHAN ONCOLOGY CONTACT: JEFFREY EISENBERG, CHIEF OPERATING OFFICER
www.xeneticbio.com/
About
Keywords: orphan drugs, oncology, endometrial cancer, triple negative breast cancer, TNBC, sodium cridanimod, anemia, erythropoietin, EPO, PSA-EPO, â„¢ PolyXen .
1. Sodium cridanimod in Phase II for endometrial cancer and preclinical stage for triple negative breast cancer.
Description: Xenetic Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on discovery, research and development of next-generation biologic drugs and novel oncology therapeutics.
2. Polysialylated EPO, in Phase II for anemia in predialysis CKD patients.
ONCOLOGY, CNS & RARE DISEASES CONTACT: EDOARDO NEGRONI, CHIEF EXECUTIVE OFFICER
www.inorgen.com/
SMALL MOLECULE ORPHAN DRUGS
CONTACT: BOB BOYLE, CHIEF EXECUTIVE OFFICER
Keywords: Oncology, CNS, Rare Diseases, Alzheimer disease, checkpoint inhibitors, immunotherapy, late stage cancer
1. Immune-oncology platform based on the secretome in selected solid tumors
Description: Drug discovery engine in Europe focused on the development of early stage assets from academic and non academic assets into therapeutic opportunities with a solid proof of concept ready for industrial partnering
2. anticancer platform combining biomimetic molecules with innovative cytotoxic payloads in late stage cancers
Keywords: rare disease, orphan indication, drug candidate, Fragile X syndrome
1. SOL784 a candidate drug in development for the treatment of Fragile X Syndrome a rare disease and the largest single genetic cause of autism.
Description: Drug discovery company dedicated to the development of novel drug candidates in areas of high unmet medical need.
3. drug repurposing in a panel of pediatric rare diseases
www.sentinelon cology.com/
NOVEL DRUG TARGETS IN ONCOLOGY CONTACT: CHRIS TORRANCE, CEO www.phoremost.com/
Keywords: Phenotypic drug discovery, PROTEIN-interference technology, firstin-class targets, collaborative R&D, outlicensing portfolio
1. R&D collaborations Pre-clinical stage asset for oncology (AML and mutant KRAS cancers).
Description: PhoreMost is using a proprietary druggable target identification platform called ‘Protein Interference’ (PROTEINi®) to systematically provide first-in-class drug discovery programs for out-licensing to Pharma.
CLINICAL ONCOLOGY: MEDICAL DEVICES AND TECH
Name SOCIAL NETWORK FOR HEALTH CONTACT: PHIL GOLZ, EVP, CHIEF REVENUE OFFICER
https://healthunlocked.com
About Keywords: Social Networking, Patient Engagement, Online Forum, Clinical trial recruitment, clinical research, online communities, peer to peer support, expert patients, patient centered outcomes research Description: HealthUnlocked is a social network for health. It connects people with the same health and wellbeing conditions within online communities where they find peer to peer and expert support, information and self-management help. They partner with hundreds of patient advocacy organizations within these communities. They additionally offer a wide range of unique solutions to organizations and businesses, specializing in access to an active health focused audience.
Assets HealthUnlocked is a social network available on desktop and iphone app
healthunlocked.com
REMOTE PATIENT MONITORING
Keywords: Remote Patient Monitoring, Wearable Tech integration, Mobile Devices, Patient Engagement, Healthcare Data management and analytics
CONTACT: MARCO FIORI ww w.m edo pad. com/
SELF-MANAGEMENT TECHNOLOGY
Description: Medopad helps doctors better monitor their patients in and outside of the hospital. Medopad is used by NHS London hospitals, BMI Healthcare, University Medicine Goettingen, and HCA – The Harley Street Clinic. Medopad recently signed its first pharmaceutical contract and is in the process of deploying its Patient Monitoring solutions for a range of conditions. Keywords: Digital Therapeutics, Technology Enabled Care Services, Long-Term Conditions, Diabetes, Patient Self-Management, Patient Engagement, Mobile App
CONTACT: MATTHEW GOODMAN, MEDICAL DIRECTOR
Description: Mapmyhealth designs Digital Therapeutics for providers and patients alike. They produce specialized platforms for diabetes, weight loss and cancer.
1. Medopad Patient Monitoring, a solution offering remote patient monitoring and doctor/patient communication for multiple medical conditions 2. Medopad Enterprise, a powerful mobile solution that is integrated into existing hospital systems
SurvivorMap – ensuring those living with, and beyond cancer, get the care and support they need to lead as healthy and active life as possible
http://www.mapmyhealth.co.uk
WEARABLE SELFMONITORING
CONTACT: VICTORIA PERRY, BUSINESS MANAGER www.cohesio nmedical.co m
Keywords: Unified Health Eco-System, Wearable Sensor Technology, Patient Self-Management Mobile Apps, Shared Care Environments, Electronic Patient Records, Clinical Workflow Software, Data Interface Integration, Disease Registries, Real-Time Data Analytics, Life-Long Health, Long Term Conditions, Cancer, Surgery, General Medicine, Specialist Clinics Description: Cohesion Medical is an awardwinning leading-edge provider of Connected Digital Health solutions. Our solutions connect stakeholders in new and more effective ways within a unifying health ecosystem. With our connected technology, we create shared bridges across health and social care services to make effective transformational change possible.
1. Patient Self-Management Mobile Application for Long Term Conditions 2. Cloud-Based Shared Care Environment for Virtual Clinics and Remote Monitoring 3. Cloud or On-Site Cohesion Clinical Collaboration Software Suite for Optimised Clinical and Research Workflows. 4. Digital Platform for RealTime Health Data Analytics
MEDICAL DEVICE OPPORTUNITIES CONTACT: DR. TOBY RICHARDSON, ASSOCIATE DIRECTOR OF BUSINESS DEVELOPMENT
www.icr.ac.uk/
Keywords: rapid and accurate slicing of tissue samples, coalignment, tissue imaging, tissue arrays, high sample density, cervix imaging, microscopic imaging, digital imaging, photoacoustic imaging, ultrasound imaging. Description: A University of London and Royal Marsden hospital affiliated research charity which ranks in the Top 4 institutes for cancer research worldwide.
1. Device for tissue processing: prototypes sold to academic researchers. 2. Endocovitary coil for improved 3T-MR diagnostic imaging of the cervix (proof of concept, clinical ongoing). 3. Polyscope: solution for visualization of digital microscopic samples (preproduction prototype in development). 4. ARF-LOVIT system: for reducing clutter in medical photoacoustic, ultrasound and other imaging using acoustic radiation force-based localised vibration tagging.