Three Levels of
2. Comfort for Mother 94% of mothers were convinced that
Other
relieved overall digestive discomfort
after 14 weeks.15
(n=34) Control Formula (n=17)
% mothers reporting improvement in colic
Benefits:
Reassurance
100
Reassurance
Clinically Proven
Confidence
• Significant reduction of crying episodes
90
in infants with colic after 1-2 weeks 16
80
**
70
*
60
77%
40
10 0
94%
• Significantly more frequent stools per day after 1 week 17
62%
30
20%
• Softer stools-more like those of breast-feeds 17
50
20
Relief
• Increased proportion of bifidobacteria
23%
Week 1
Week 2
in the stools benefits 12 Week 14
Significantly different to control group,*p < 0.01, **p < 0.005
3. Comfort for Doctors
Formulated with Prebiotics, and with:
95% of paediatricians agree that
• 100 % partially hydrolyzed whey protein • 41 % fat in the ß-position • 61 % less lactose (Comfort 1)
Confidence
% infants showing an improvement in minor feeding problems
significantly relieves colic, posseting, and constipation in bottle-fed babies within 2 weeks of feeding.11
To provide comprehensive relief from digestive discomfort.
100 80 60
* 79%
* 70%
40 20 0
* 63%
significant reduction in episodes of colic
significant reduction in frequency of symptoms
significant reduction in constipation
Colic N=214
Posseting N=210
Constipation N=232
Significantly different to control group,*p < 0.05;
Breast Feeding is best for babies. Aptamil Infant milks are intended to replace breast milk when mothers cannot or choose not to breastfeed. It is recommended that infant milks are used only on advice of the doctor. Follow-on milks should be used as part of the mixed diet and not as a breastmilk substitute before 6 months.
REFERENCES: 1. Forsyth BWC, Leventhal JM, McCarthy PL. Mothers’ perceptions of problems of feeding and crying behaviours. A prospective study. AJDC 1985;139:269-72 2. Garrison M, Christakis D. Early Childhood, colic childhood development, and poisoning prevention. Pediatrics 2000;106:184-90 3. Wessel MA. Cobb JC, Jackson EB, Harris GS Jr, Detwiler AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics 1954;14:421-35 4. Van den Berg MM, Benninga MA, Di Lorenzo C. Epidemiology of childhood constipation: a systemic review. Am J Gastroenterol 2006;101:2401-9 5. Billeaud et al. Eur J Clin Nutr 1990; 44: 577–83. 6. Tolia V et al. J Pediatr Gastroenterol Nutr 1992; 15: 297–301. 7. Harms HK, Hecker WC. Krankheiten der Verdauungs- und Bauchorgane. In: Lehrbuch der Kinderheilkunde. Schulte FJ. Gustav Fischer Verlag 1988 Stuttgart, 285-373 8. Horvath A, Dziechciarz P, Szajewska H. The Effect of Thickened-Feed Interventions on Gastroesophageal Reflux in Infants: Systematic Review and Meta-analysis of Randomized, Controlled Trials. Pediatrics 2008; 122:e1268-77 9. Carnielli VP, Luijendijk IH, Van Goudoever JB, Sulkers EJ, Boerlage AA, Degenhart HJ, Sauer PJ. Structural position and amount of palmitic acid in infant formulas: effects on fat, fatty acid, and mineral balance. J Pediatr Gastroenterol Nutr 1996;23:553-60 10. Moro G et al. J Pediatr Gastroenterol Nutr 2002; 34: 291–5. 11. Savino F et al. Acta Paediatr Suppl 2003; 441: 86–90. 12. Schmelzle H et al. Randomized double-blind study of the nutritional efficacy and bifidogenicity of a new infant formula containing partially hydrolyzed protein, a high beta-palmitic acid level, and non-digestible oligosaccharides. J Pediatr Gastroenterol Nutr 2003; 36: 343–51. 13. Carver JD.Advances in nutritional modifications of infant formulas. Am J Clin Nutr. 2003 ;77(6):1550S-1554 14. Carver JD. Dietary nucleotides: effects on the immune and gastrointestinal systems. Acta Paediatr 1999;430:83-8. 15. Veitl V, Wells JCK, Helm K, Lamme W, Muller H, Kafka C, Bronstrup A, Bockler HM. Akzeptanz, Toleranz und Wirksamkeit von Milupa bei Sauglingen mit kleineren Ernahrungs-und Verdauungsproblemen. J Ernahrungsmed 2000;2:14-20 16. Savino F, Palumeri E, Castagno E, Cresi F, Dalmasso P, Cavallo F, Oggero R. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006; 60;130410. 17. Savino F, Maccario S, Castagno E, Cresi F, Cavallo F, Dalmasso P, Fanaro S, Oggero R, Silvestro L. Advances in the management of digestive problems during the first months of life. Acta Paediatr Suppl 2005;94:120-4
Information for healthcare professionals
RCT, N=51 infants (< 3 months old) age with at least 1 GI symptom, followed for14 weeks
TEIN O R P D E Z HYDROLY E S O T C A L LOWER ND E L B T A F E U UNIQ
(1-7 days)
Observational prospective trial, N= 604 infants (932 enrolled at start), < 4 months old, with GI problems ®
®
is uniquely formulated to relieve a range of symptoms acting on Three Levels
of all parents reported that their infants had moderate GI problem, leading to a change in formula 1
1. Comfort for Baby
100%
e er an c it ns
se ity iv
%
of newborns are affected by colic and excessive crying in the first 3 months 2
For easier digestion and softer stools 5, 6 Protein
improved symptoms of digestive discomfort after 14 days 15
90
For easier digestion, decreasing flatulence and intestinal discomfort 7, 8 • Comfort 1: 61% less lactose than standard
Peptides
• Comfort 2: 40% less lactose than standard Amino Acid
According to the Wessel Criteria, colic is defined
Immature digestive system
60
77
Standard Formula (n=17)
72
*
50
50
40
60
50
30
40
20 10
23
22
14
0
11
abdominal discomfort
overall
id
crying with cramps
constipation
possetting
RCT, N=51 infants (< 3 months old) age with at least 1 GI symptom, followed for 2 weeks
Ca2+
ß
id
itic ac
• insoluble calcium soaps
2
With a ß- palmitate content that closely mirrors breast milk, • Improves fat absorption • Reduces constipation-inducing calcium soaps of fatty acids (CSFAs) 9 9
Lipase
Unique fat blend
⇓
contribute to stool hardness and constipation1
Triglycerides with α- or ß-palmitic acid Triglycerides in standard infant formulas
ß-palmitic acid
palmitic acid in α-position
Constipation of infants are affected by constipation, one of the most common GI disorders in childhood 4
Triglycerides in human milk and Aptamil™ Comfort
is Clinically Proven to reduce the number of crying episodes in colicky bottlefed babies
16
α-palmitic acid
α-palmitic acid
α-palmitic acid
29.6
** *
70
itic ac
α-palm
• Cows’ milk protein sensitivity • Lactose intolerance • Immature digestive system
%
(n=34)
**
*p < 0.05, **p < 0.005, ***p < 0.0005
α-palm
glycerol
Dietary causes have been linked to:
Lipase
glycerol
The cause of colic is unknown but suggested causes include dietary and psychosocial.
α-palmitic acid in standard infant formula
glycerol
by the Rule of Three:
3
80
(n=96)
ß-palmitic acid
Control Formula with simethicone (n=103)
7 α-palmitic acid
palmitic acid in ß-position
also contains: Prebiotics: a unique prebiotic blend (GOS/FOS) that promotes the growth of healthy bacteria in the gut, and improve stool characteristics 10, 11
A Thicker Formula: for smooth food delivery and reduction of air swallowing when feeding 12
Relief
Number of crying episodes
16 -26 %
Lower lactose levels
in to l
ilk m
Colic and excessive crying
s’ w Co
partially hydrolyzed whey protein
La ct os e
35%
, Clinically Proven to alleviate symptoms of GI discomfort
% of infants showing improvement after 2 weeks
Prevalence of Digestive Discomfort
6 5
59%
5.99
70%
5.41
4 3
*
2
3.72
2.47
1
3.32
* 1.76
0 Day 1
Day 7
Day 14
* significantly different to control group, p<0.0001
LCPs (AA & DHA): essential for visual and mental development 13 5 Nucleotides: important for GI Maturation
14
RCT, N=199 (< 4 months old) full-term infant having colic, followed for 14 days