AmnioFix: Advanced Healing and Inflammation
Modulation
AmnioFix is a bioactive tissue matrix derived from human amnion / chorion membrane, designed to modulate inflammation, reduce scar tissue formation, and enhance healing.
Growth Factors in AmnioFix
AmnioFix contains 226 growth factors, cytokines, and enzyme inhibitors, which support tissue repair and regeneration. The most notable include:
• TGF-ß1 (Transforming Growth Factor Beta 1): Promotes healing and reduces scarring.
• FGF (Fibroblast Growth Factor): Stimulates cellular proliferation and supports collagen formation.
• PDGF (Platelet-Derived Growth Factor AA & BB): Enhances soft tissue healing and cell regeneration.
Extracellular Matrix Components
The extracellular matrix (ECM) in AmnioFix includes:
• Structural Proteins: Collagen types I, III, IV, V, VII, and elastin.
• Specialized Proteins: Fibronectin, laminins, and TIMPs (tissue inhibitors of metalloproteinases).
• Proteoglycans: Essential for cellular function and tissue hydration.
These components help stimulate native cells to enhance their immunomodulatory response, further aiding healing.
PURION Process: Safe and Effective Processing
AmnioFix is processed using the proprietary PURION Process, which ensures a safe, easy-to-use allograft with a five-year shelf life at ambient temperature. This dehydration process preserves bioactive properties while maintaining stability and ease of application.
Stem Cell Recruitment and Healing Mechanism
AmnioFix acts as a Stem Cell Magnet, attracting mesenchymal and hematopoietic stem cells to the injury site. These recruited stem cells modulate inflammation, release growth factors, and accelerate the natural healing process.
Proven Clinical Use and Immunological Safety
• Over 500,000 allografts have been distributed with no reported adverse reactions.
• The human amniotic membrane is immunoprivileged, meaning it does not trigger an immune response.
• Since 2006, MiMedx has been a leader in regenerative medicine, publishing over 25 clinical studies and securing 20+ issued patents, with 80+ more pending.
Ideal Use Cases for AmnioFix
AmnioFix may be an option for patients who:
• Have inflammation-related injuries and need enhanced healing.
• Have not responded to anti-inflammatory medications, physical therapy, or steroid injections.
• Seek a non-steroidal alternative that delivers natural growth factors and collagen to support tissue repair.
