Fitzpatrick's 2008 - Part 11 - Therapeutics

   

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

                                                             

                                                                                                                    

                           

      

 

                                                                       

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

                                                          

           



            

                                                                                                                                                                         





                          

             

                                                                                                                                      

  

                                                                          

                                                                          

 

          

 

 

  

    

      

      

      

      

 

 

 

 



                                                                                                                                                                                                                    

                        

                                                                  

                                  

                

                                                                            

                              

                              

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                                                                                                                                           



                               

                                                                                                                                                                                                                  

                                                  

                                                                     

                                                                                                                  

                                                                                                                                          

                                                         

                                                                   

                                                                                                  

                        

 



                                                                                                                                                                                                    

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 

                                                                                                                                               

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                                                                                                                                                                                                            

                                                                                                                               



                                                                       

       

                                                  

                                 

                            

                                      



  

                                                                                                                                                                

 



                                                      

                     

               

                                                  



  

   





  





   

  



                                                                                                





          

                                                                                             

                                                                                                                                                                                                                                          

   



 



           

           

  

  





 

                                                                                                                   

                                                                                                                                    

             

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                                                                                                                                                                                            

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                                                                                                                                                      

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                                                                      

                                                                                                                                                                                                                     

                                                                                                               

                                                                                                                                        

                        

                                                                                                                                                                                                 

                                                                                                                                                                                                                      

      

                                                                                                                                                                                                                                 



             

                                                                          

                                                            





       

                                                      

  



 



       

                                                                         

                                         



                                                                                             

  



                     

     

                 

                          

                                                   

   



                                

                       

                                                                                               

                                              







 









   





 









 

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                                                                                                            





                                    

                      

                                                                                                

                                       

                                                                                               

                

  





       

             

                     

                                                                                    

                                                                                               

             

                

                                                  

                                                                                                                                               

        

                                           

                                                                                       

       



       

                  

                                                                      

                          

   



                            

                                                                

                              

                                                                                        

                                 



                                                                         

                                               

                











    

 

                                                                                                                                               

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       

                                                                                  

                                                                        

                                                                                                                                                            

                                                                                   

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

                                                                                                                                                                                                                                                         

    

   



   

 

 





 

 

        

 







                                   

                                                                                        

                                                                         

                 

      

 



  

  

 



 

                                                                                                                                                         

                                  

     

                                                                                                                             

                                                                                                                                                                     







 















 



  

   

 





  



 



 



 





  



 









  





 

 

    

   

  

 

 



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                                                                                                                                                                                                                                          

                

                                                                                                                                                                                                          

                                                                                      

                                                                                                                                                       

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                                                                                                                                                                                                                                                                         

                                                                                                                                                                                                                            

            

                                                                                                                                                                    



                                                                                   

                                 

                                                                                                

 

       

                           

                                             

                             

                           

                      

  



 

 





























 

 









 





























 

















 









 











































 











     



                                                

                                                                

                                          





                                                   

                                                                     

                                                               

                                                                                                        

      

                                                                                                                                                       

                                      

                                                                                           

                                                                           

                                                            

                                                                                          

             

 



                                                                   

                           



                

                                                       

                                                                     

                                    



                                        

                                                                                                          



   

               

                                  

                                                                                   

                            

                                                                           

                               

  

                     

                                                  

    

  



        

   









                      

 

















 











 

 

 

  

 

 

 









   

 





    

     













   









    

   

   



  

  

                      

                       

                                                                            





                                                       



                                                                                                                      

                          

                                                                  

                                                                                                                                    

     

                                                                                          

          

                                                                                            

                                     

                                                  

                                                                                                                

               

                                                                                 

                 

              

  

       



   

 

 



 

 



  

  



   



 





          

                                            

        





                                                    

                               

                                                                                                                                            

              

                                              

                   

                                                                                                         

                                                                                                                                                         

                                                                 

                                                                              

                            



              

                                                                                           



                                                                                                         



      

                                                 

                                                           



                                                                                                                                                                       

 



 

                                       

                                      

  

                                                                                                                                                                                

      

                                                                 

                                                                                                                   

                            

                 

  

                                                                                               

                                                        

                                     

                                                                       

                                  



                              



                                

                                                                                                                                            





                                

                           



                    

                    

                                                     

 

          

                   

        

                                                                                                                              

 

                   

           

                                     

         

                                              

 

                       

 

                                                                                     

                                                                                                                                                   

                                                                                                                                          

                                               



 



  

 



    

                                      

                                                                                                                                                                           

                                                                                            

                                                      

 



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                                 

                                                                                                      

                                                                                             





 

   

 

   

   

    



   



 





  

 

 

 

   



 



        



                                                                                                                                                                                        



 

     

                                                                                

      



    

   

    

 





                                                     

                                                                                                                                     

  

                 

       

                       

                                                                                



                                                                    

                                                                                                     

                                                                               



                                      

                                         



              

      



                                                                                                           



                         



                                                                              





                                                    

                                                                                        



                                                                                                               

 

              

                        

                                                                   

  

                  

   

 

  



   





 



         

   



   



 





   

      

     



 





 

 

 

 

 



 

 

 

   



 



  

    

        

       







      

   

         

    



 



   

  

  







    

  

  

      

   







   

 

  



   







 

   

  







 



 

 







 



 

 

  

  



  



 

 

   

  







  

  

    

      



                                            

                                                 

 

       

              

                                                                                                                

                               

                          

                                                

               

                                                  

                                                                 

 

  

                      

                                                           

                                   

                                                                                                                                      

 



  



  



   

 



 

  

  



 



   

 





 





 





 

 















    







 













 

  





 

   

   





 

   



 







 



 

 







                                                          



                    

 

   

 

                                                                                

  





                             

         

                                

                                      

                          

                 

 



   









 

 



 



   

 

  





    



  





 

  

  



 



 

 

 

                        

     



                            

                                                        

                                                             





                       

                        

                               

                  





                                                                           



                    

                                    

                                                                        





                                 



                                                                                  

                             

                         

  





                                                       









   

                                     





     

                                    

 

                                              







              

      

                                                  

                                                                                                   



          

                                                            

                                 

                     

 

                                                                                                                                                      



                                                       



       

 

    

                                                              

            

                             

  

 

  





                                                                                 





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                                                                                                                 

 

  

                          

  

 

                                                          

   



 

 

 

 

  



 

 



 

 

 

   

 

 

 

 

 

     

                                                                                                  

                                                                                 

                                                                   

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 

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 

 





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                                                                                                   



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                                        

                                

                                 

                                                           

                                                                                                                                                                                                                                            

                                                                                                                                                             

                       



                                         

                                                               

                                                                                                                    

  

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  







   

  





 

 





 

    





                                                             

                                                     

    

                                                                                                                

                    

                                    

                    

 

                                                                                     





                                                         

  

  



             

                                                    

                                                         

  

                                                                               

                                              

                                              

                                 

   

               



                      

                            

                                               

   





               



                                                                                                             

                             

                                                      

                                                                                                                                                              

                                                                                                                                   

             

                                                                                                        

                                                                                                                  

  









                    

                    

                    

                   





  





                     

    



                                                                        

                                                





                                                                      

                                                          

                    



                                

  

              

                      



                                                                             





                                  

                                                                      

                                                                                                                                                                      

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

                               

               







 









  

      



 

 











                                                                               





                                       











      

      

      

      

      

                           

    

                 

       

                                                                                                                                    

              

  

  

  

 

 

 

 

   

   

   

   









                                                                                                                                                                        

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                                  

            

                                                                                   

                                                                                          

                                                    

      

 

                       

                                                    

                                                                             

                                              



   



  

                  





      



       

                                                                                               

                                                                                                 

                                                                                              

                          

                                                         

           

                                                                                                                             

                                                               

                                                                                                                    

                                                  

      

                                                                       

                                        

                                                                      



    

  



                                                                                    

                                                                                         

                                                                                



  



 



   

   

 

 

                                                                       

                             

 





                        





                                                                                        





                                                                                                                                                                             

                                                           

                                                                     





                                

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 

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                                                                         

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 









 

  



 

 

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 



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 

 



                                                                                  

                                           

                                                                                      

                                          

                                                                                                                                

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                                                                                                                                                           



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                                                             

                                                                                                                                                                                                                                                       

                                                                                                                                                                         

                                                                                                                         

                                      



      

                                                             

                                                                              

                                                       

               



                                                                                                          

                                                                                           



 



                                   



                                

                                                                                                                                                                                                                                                   

                                                                                                                                                                                                                                            

                                                             

  

                                                

                         

                  

                                                                              

  









             

        

 

           

       

  



                                                                     

                                                                                            

  



                                                                



                                                               

   



                                                                                               



                                              

                                 

             

                                                                                                                            

                                                                             

  

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 

 

                                             

                               

                      

 

                                                                              

      

                                                                                                               

                                                                                                                                                                                                                                                 

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

                                                 



                                                                                                                               

        

                                                                                                  

                        

                                                                                     

                      



                                            

             

                   

                      



                                

  

    



                                                                                                                            

                                                                                                                      

                            

                                



                                      



                                              

                                                                                             

                                                                                                                                                                                            

  



                      

                     

                                                                                 

                                                                              

                                                           

                                           

                       

                                           

                                                                                                                       



   



  



   

 

 

 



   

                                                                                                                                                

                          

                       

                                                               

                                     

                                    

      

                                                                                                                                                                                                                                                           

                                

                                                                                                                                                                                                      

                                                                                                                                                                          

     

 

     

  

                                                                                                                                                                           

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                                                                                                  



       

                                                                                                                                                                      

                                                                                                                                                           

         

                                                                                                                                                                                                         

  

  

                                   

                                            

                                                                                                    

                                                                                                                 



                                                                

                                                                               



                                                     

 

 

            

                                  

                                                                                                                                                                                         

                                                                            

                                                 

                                                                      

 

 

                       

                                         

                                                                                                      

                              

                                       

               

                

                                                                                                      

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                                                                                                                                                     



 

 

                                                                                                                                                               

                                         

                                                                                                        

                                                                                                                                                                                            

  

  

                                              

                                

                                                                             

                                                                                                                                         



                                                  

                                                                                                           



                  

 

 

                                       

                                        

                                                                                                                           

                                                                   

                            

                                                                                                                                                               

                                                                                                                                                                      

                                                                                             

                                                             

                                              



  



 







 

 



  



 

 

  

  



 

 



 





 

  







 



 



   

  

 

   



 

 



  



  

 



   



       

                                     



  

                                                                                          

       

           

  

  

               

         

  

                        

                                                                                                                                   

         

  

             

                                                         

                         

         



                                                 

                                                         



                                                                                  

 

                                                                                                                                                          

  

                   

                       

                         

  

                                                                                                                           

                                                                          

                  



                                                                                                                                                                             

                                                                                                                                                                                                       

                                                                                                                                           





     

                                 

             

                                                                                                                                    

                                                                                                                              

                                                                                                

                                           

                                                             



                  

                                                                

 















                                                           







                                               

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

                    

              

                                                                                        

                  

                                                                                                                        

        

                                                     



                                                            

                                         

                                                                                                                    

                                                               

                

                                                                                                                                                           

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                                                                                                     







                                                                                         

                               

                                                                                         

 

                                                                                   

                                

 

                                                         

                             

                                     

                      

                                      



 



                                                                                                                                                 

                              

                           

                                                                                                                                     

                                       

                                    

                         

              

                      

                                              

      



                                                                    

                                           

   



                                          

                         

                                     

                                                           

                        



             

                                                   



                                                                                                                     

                                                                  

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                                                                                                                    

                                                   





                 

      

                                                                                                                                                                                              



 



 

       

 

 

  

 

   

    

    

 

  

          



                                                                                          

                                                 

                                      

                                     

              

                                                         

                                                                  

                                  

       

     







   

       



   



                         

 

       

     



  



 









 

   



 















   

 





                                                                                                                                              

                                                            



         

                                                                                                                                                                                                       

                                       

                                                                                                                               

           

                                                                                              

                                                                                                           

                                                                           



                                                             

                                                                                                    

                                             

                                                                                                                   

       

         



 

   









   



 



  

  





 

   





 

 



                                                             

                                                     





           

                                                                                                                                 

                                       

                                                                                                                     

         

                                                               

                                                                                      

  

                                                                                       

                                                                                                   

                                                

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                                                                                            

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                                                                                                                                                                                       





                                                                  

                                                                                               

             





            

         



                         

                                                                                      

            

                       

   

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



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

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              

 

 

        

           

            



 







  

                                     

                                                                                 

                                               

 







   

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 

    

                                                  

                                           



  

 









  





 





  





 

 



    

 



 





 

                                                    

 



                                                                                                   

                                                                                                                           

                                      



                                             

  





  

                           

  

                        

                        

  



                                                                                                                                                                                                     





                             

                     





   

         

                                                                                        

           



                                                             

                                                                                 





           



 

 

                                         

                                                                                                                     



                                      

        

         

                                                                                                                           

                                                     

                                                                







 

                                                               



 





                                                                                  



 

                  

                              

                                                      





 



                



                                                        

                                                                                                        







 

           

                                      

           

                               



 



                                                                                                                                

                                       

                                                              

 

                                         

                                      







 

 





 

                                        



 

                            



 

         



                                                    

                                                                                                                       





                                           

                                                                  

                                                                                                                    

                                       

                                                            

                                                                                      

                                                                                    



      

                                                                                              

   

                                                                    

                                

                                     

               

 

                                                                                                                                                                



             

                                                                  



  















 

  









  









  



















  











              









 

 

  









 







 







   

                                                                               



                      





             

     

         

                                          

  













































 









 









                        

 

                                                                                                                                        

















 

 

 

 

 

   







  

 























 









                            

   

                     

                   

                                             

   

   

 

                      



   

  









 





 

 





 





 



  









 

 

 

         

                                    

                 

                                                 



     

                             

    

         

                                        

                                               

  









 

 

  

 

  

 

 



          

 

                                                                                           

                                    











 

 

  

 

                                                           

       

                                  

                                                                                                                  

  









 





 

    



  



    









                                                           

                                                                                                                                                     



          

                                                                                                                                                                                                                          

                                                                                                                                                                                                                                          

                                                                                

                                                                                                              

                                                                                                                                                                                                   

                                                                                                                                                                    

                                                      

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                                                                   



                                                                                                                                                                                  

  



 

 

  

  

                                                      

      

  

                                  

                

                                                                                                  

                                                                                        

                                                                         

                              

                         





                                                                                                     

 

           

 

                                                                          

            

                                                                                                                      

                        

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                                         

                                                                        

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                                                                                                                                                                                                    

                                                             

                     

                          

                  

                

  

 



  

  

  



        

                                               



 





                             

        

                          

       

                                                                                          

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  

                 

                                      



  



     





     

     

      

    



 

                                               



               

       





                                              

          

                                                                                             

                                                                 

                       

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       

                                                                                                                                                                                                                                       

                                 

                                                                            

                                                                                                                                              

                   

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     

                                                                                                                                                        



        

                                                                                                                                                  

                      

                                                                                                                                       

                                                    

                                                                         

      



                                                                        

                                                                     



                                                                 

                                                  

                                                                                               

                                                                                                                                                       



   



  



             

                     

                                                



               

                                                      

                                                                                                                                                                          

   

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

 

 

                                                                                                                                                                                                                                                     

                                                                                                                                                                                                                                

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                                                                                                                                                                                                                                          

                                                                                                                                                                                                                                 

                                                                                                                                                                                                                                          

     

   





   

   

                                                                                                                                                                                               

                                                                                                  

                                      

  

                                                                                                                                                                         

 



                                            

                      

                                                                

                                                                                                          

                                                                  



         

        





          





                        

                                      

      

 

          

                                   

                                              

                                               



                               

      

                         

                                                

                        

                                               

     

  

                              

 

      

                   

 

            



    



                   



                                                                                 

                                                                                                                      

                                                                                                            

                                                                                      

                                                                          

                                              

                              

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                                                                                                                                      

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                                             

                                                                                                                                                                                                                                                                                         

                                                                                                                                          

                                                                                

                                                                                                                                                                              

                                                                                                                                                                                                                            

                                                                                                                                                                                                                                        

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                                                                                                                                                       

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                                                

                                                                                                                                                                                                                                          

                         

                                                                                                                                                                                                  

                                                                                                                                                                                                  

                                                                                                                                                                                                                                                   

                           



                                                                                                                                                                                                             

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                                                                                                                                                                                              



                                                  

                               

                                                                                   

                                                       

                                                                                                                                                                                 

                                               

                        







               

 

                                  

                                                              

                                          

                                                                                     

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 



                                                                                                                               

  



   



  

              

  







 

     

   

  

  





  

 

   



                                                                





                       

                  

                 

                                

       

                                                                      

 

                          



   





   

 



 

  



  





                       

                          





                           

                                            

 





                                             

                         

             

                                                                                                                                                                     



                                                                                                

                                                              





                           

  

 







  



 







 

                                     

         

                                                                                        





                                   

                                                             



                          

           





               

                           

                              

                        

                                   

  

                                                                    

                                

                     

             

                   

    

             



                                                                                         

 





 

    



  



 

 







  



    

 

   



 

                                               

   



                                                        

                                        

              



                                   



                                                                                       

             

                







                       

                       

  

 

  







  







    



       

                                    

 

                                                                

                                                        

 

                                  

                 

   













 

 

         

  



          

  

    

  







  





                                 

                                   

                       

                                                                                  



                                   

                                                                   

 

       

                                             



                                                         

  



 

     

     

     

       

  

   

  

   

 

 



 

 





 

 







 





       

     

 

 









  

  



     



                                          

                                       

                                                                                                                                                           

   









 



  









  



 

   

  

   

 





  



                                         

                           

                      

                                                                                   

                                           

               

          

















          

          

          

            

 

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          

                       

                         



                        

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

                                                                                                

         

                     

                                                                                                                                                                                       

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

               

                                                             







 













 





 

 

 

















                                                                    

                     

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                                                                                                          

                                                                                                                                                                                                 

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  

            

                                                                                                                                                                                                  

                                                                                                                                                                                                                                          

           

                                            

                                                                                                                                                                           

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                                                                                                                                       

 



                  

                                                                                                                                                                            

                                                                             

                                             

                          

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                                                                                                                                                                          

                                                  

                                                                                                                   

                                                                                                             

                                                                  

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                                             

 

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                                                                                                                                                                                                                      

                                                                                                                                                                                                                                                                          

                                                                                                                                                                                                                                                 

                              



 

    

      

                                                           

                           

                       

                                                                    

                                                        

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   





                                             

   

 

                         

         



                                                                                                                                                                           

                                                                                                            

        



  

   

  









  









  

 











 









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                                            

                                                                                                 

                                                                                                                                                                                                                           

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                                                                                                                                                                      

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                                                                  

                                                                                                                                                                       

                                                                                                                                                    

                         

                    

   



 



  

       

 

           



                                                                                   



                                                                                    

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                       

                                                                                                                                                                                                                            

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                                                 

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                                                                               

                                                              

                                                                             

                              



                                      



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         

                                                                                                                                                                                                                                                         

                                                                                                                                                                                                                  

                                                                                                                                                                                                                                               

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                                                                                                                       

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                                                                                                           

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                                                                                                                               

                                                                                                                        

                                                                                                                                                                                                                 

                

    

                                                                                                                                             

                                                                                 

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                                                                                                                                                                   

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                                                                                         

                                                                                                                                                                                                                                                 

                                                                                         

                                                                                                                    

                                                                                                      

                                                                     

                                                                                                         

                                                                                        

               

             

                                        

                                            

                                                                                                           



        

                                                                                                 

 



                                                                       

    

                                                                                                                                                                                                                      

                                                                                                                                                                                                     

                         

  



                  

                 



                                                                                                                                                                          

                                                                        

                                             

                                                                                                       

                                                                                             



                 



 





                                                                                                                    



                                                            

                         

                                                                                                                                         

                                     

                                                                                                                                                                            

                                                                                                                                                                                                                                 

 



                                   

                                          





 

 

    

 

 

 

 

    







     

 

 

   



 



 





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 

  



                                                                             

                                                        

                                                                                                                                                             

                                                                     

  

 









 



 





























  







 

  



















  



 



 

 









  









 









 









  







 











 









 









 

 





 

  



                                                     

                                                                  

                                                     

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                                                         

 

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                                                                                                                                                                                                            

                               

                                                                                                                                                                                

                                                           

                                                                            

                                                                                                     

    



                                                                                    

                                                                                                                 





             

                                                  

                                                            

                                                                                                                                                  

  

 

 

 

 

 

      



      

   



    

     

  

     

  

                                                                                                                                                                                                                                                                                                                               

                                                                                                             



                                                                                                        

                                                                                                                                 

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                                                                                                                                                                                                                                 

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    

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                                                                                             

                                                                                                                                                                          

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                                                                     

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                                                                             

                                                                    

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                                                                                                                                                                                                  



                   

                                                                                                                                                                                                                                                          

                                      

                                                                                                                                

                                                                                                                                                                                                                                                              

                                                                                                                                                                                                                         

                                                                                                                                                                               

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                                                                                                                                                                                      

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                                                                       

                                                                                                                                                                                                                                             

                                                                                                                                                                                                                                 

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     

            

                                                                                                                                                                                             

                                                                     

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                                                                                                                                                                                     

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             

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                                                

                                      

                                                                                                

    

 

  

  

   

 

  









 



 

 

 





  

 

 

  

 

 



    

 

  

 







  

  

   

  

 

 

 

    







   

                                                                                                                                                                                       





                                                              

                                                                                                                                                                            

                                                                                                                                               

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                                                                                                                                                                                               

                                                                                                                                                               

                                                                                                                                                           

                                                       

                                                                                

                                                      

                                                               

                                                                                

                                                                         

                                        

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                                                                                    

        

                                        







                                                                         



                                                              

  

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





 

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



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

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

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

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 

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

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 

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



                                                                                       

       

                                                   

                                    

  



 

 

 



         

                   

         

         

      

                                                                      

                                                                                                 

            

                                                           

                                                                                                                                                 

                          

                                                                                                                                                                           



   



 

         

 

   

 

     



                                                                                                                                                                   

                       

                                                                                         

                                                                                                                               

   

 

 

 



 

  

 

 

 



 

   

 

 



 



     

  

  

  



  

     

  

  

   

 

   

 

 





   

 

 







 

       

                                                                                                    

                                                         







           

                                                               

                                                            

   

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  

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                                                                                                                                    



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                                    

                                                                                                         

                                                                                                 

                                                                                         



                                                           



                                                                                                      

              

 

                                                                                                                             

                                

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                                                          

  

                             

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                                                                                                                

                                                               



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                                                   

                                                                                                                                                                                                                                

                                                                                                                                               

         





                                                

                                                                                         





                                                                                                                                                                        

                                                                                                                                                                                                         





        

                                                                                                                                                                          

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                                                       

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                                                     

                                                     

                                                             

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

                                  

                                       

        

                                                                                                                                                                                                         

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   



                                      



  

    

 

 



 

     



                                                                                                          

 

                                                          

                             

                        





    

  

  

 





 

                                    

                                                                                                                                                                                                              

                                            

                                                                                                

                           

                                                     

                                   

                                                                   

                



                                            



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                                                                                                                                                                                                        

                                                                                                                              

      

                                                                                         

                   

                               

                                                                                     

                                                                                                       

                                          

                                                                                                                       



    

   

     



                                                     





                                                                       

       

                                                                                                  

                         

                                                                                                                                                                                                      

       

                                                                                                                                                                 

                                                           

                                                        

                                        

                                          



                    

                                                                                                                                                                                                                                                           



                  





 



 

 

 

      

      

      

      

      

      

      

 

      

      

      

      

      

      

   



                                      





                                                                             

                                                                                                                          

                   

                                              

                                                                                     

                                                                                                                                                                                                                                                

                              

                                                                                                                                                                                 

                                                                                                                                                                                                      

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                                                                              



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                                                                                                                                                   

                                           

                                                                                                                                                                    

                                                                                                                                                                                                                  

 

                  







 

        

        

        

        

       

       

       

       

                                                           

                                                               

                                                                                                                             

                                                                                                           



 



                                                                                                                                                                            

                                                                                     

 

                                                                                                                                             

                           

                                                                                                                                                                                                                       

                                                                                                                                                                                                                         

                                                                                                          

                                                                                



                                                         

                                                                                 





                                  

                                                               

                                                                       

                                    

 

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                                                                         

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                                                                                                                               

                                                           

                  

                 

                                                                                                                                                    



                                            



                                                                                                                                                                                                    

                                                                                     

                                                            

                                                                                                                                             

                               

                                                                                                                                                

 

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                                        

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                             

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    

                                                                                                                                                                          

                                                                                                                                    

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               



                                                                                                                                                                                               

 

                                                                                                 

         

                                                                                                                             





                         

  

                                            

 

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    

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                                                                                                                 

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    





 

                                                                                                           





              

                                                                                                                       

                                           

                                              

                    

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                                                           

                     

                                                

                                                                                                                                                                                                                                   

                           



  

       

     

             

                             







              







                            



                                  



     

   

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   



  





                         



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

       



                                                                                                                                                              

                                              

                                                                                        

                                                

   

                      

                                                                                                                                                                                           

                                                   

  



                                                                      



 



                                                                 

                                                       

                          

         



                                                                             





                                                            





 



 



 

 



 

 



 

 

 

                                                                                                   

 

                                                        

       

   

    



                                                                                                  

















                                                                                                          

                         





                                        

                                                                            

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                                                                                                     

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 

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                                   

 

                       

                                                                                                          





 



 

 







                 

                        

             



                                                                                                                



    

 

                                                                 

                                                                                                      

                                                                                                                                                 

            

                                                          

                             

                          

                                                                                                           

                                                                                                   

                                                

 



                                                                                        

                              

                                               

   



 

                                                   

                                                                                     



                                  

                                                                                        

         

                                                                                      

   

        

           

                  

                              

                     

 

                                                       

                                                                                                                                              

                     

                                                                                                                                                 



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            

  

                                                            



      



                                                                                                    

                                                                                                                                 

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  

           

                                                                    



                         



                          

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                                                                                                           

                                                                             

                                                                                                   

                                   

            



  

   



   

                                                                                                                         

                                                                                  

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    



                                                                        



                                                                                                                                                                                  

                                             

                                                             

  

                                                                                                                                                                   

                                                                 

                                                                                                                                                                                                                                                                                           

                                                                                                                                                                                                                                                 

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                                               

          



                                                                                 

                                                                     





                                             

                        

                            

  



   

   

                                                                

                    

                                                                                                   



  

  

    

                                                                                                                                                                

                                                                                                                                                                                

        

             

                                                            

                                                     

                          

                          

                     



                                



                                                                                      



                                     

                                     

                             

                                                   

                                                   

  

     

 

                             

                        





                                   

 

                                             

                                       

           

 

                          

                              

                                                       

                

                                                                               

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                                                                                                        

 



                                                                                                 

                                                                                               

                                                                

    

                                                                                                                                                                                      

                                      

                                                                                                                       

                           

                                                              

       

                                                                                                                   



 

  

  

                  



                   

  

               

 



                                 

                                         





                                                                     

                                                                                                                    

             

                                                                                                                    

          

                                                                                                                                                                                 

                                                                   

                

                                                         

                                                                                          

                                                           

            

                                 

       

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                     





                                                                     

                                                                             

             

                                                                              

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                             

                                                                                                                                            

                

                           

                                    

                                                          

                

                                                                                                                           

                                        







         

                                                     

                     

            

                         

                      

  

        







       

      

             





         

 





                               

           



                                                            

                                                  









                                                                                                                         



      



                                                                                                                                                                                                                              

                                                                                       

                                                                              

                                                             





                                

                                                                     





     

 

 



                                                                                                                                                                       

                                             

  

                                                                                                  

              

  

 

   

 

  

  

                 



  





    

  

   







 

   





  





  









 



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

     



                                                                                                                                                                                         

                                                                                                                                                                                           

                                                                                                                                                                   

                                                                         

                                                                                                                                   

                                                                                                                                                                                                                                           

                                                 

                                                                                                                                                                           



  









    

    



      







   

 

                                                                                                                                           





                                                       

 

                                                            

                                                                                                                      

                                       

                                                                                                                    

                                                                                               

                                                                                                                          

                                                                              

                                                                                                                                                                    

                                                                                                                                                                                                                                 



                                                                                                                 





                                                                                                                  

                                                                                                                                      

                                              

                                                                                                     

                                                                                                                                                                                        

                             

                     

 

                                                                                                             

                                                

                        

                                                                                        

                                                                                                             

                                                                                                     

                                                                                                                  







                 

                              

  



                                            

                                                                                                                         

        

                                                                                    

                                              



 

  

   

   









                                                                                                                    

                                                                                           

       



                                                                   



 

           

                  



                                                                                                                      

  



          

             

 

           

                    

                                                                                   

                                                                                                                                                                                                          

   











 



  

   



   





  



 

  







 



 

 



  

 



 

 









 

  

 



 



 



 

  

 





 

 

 

  



 

                                                         

              

                                                        

                                                                                                       

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                                                                                                                                             

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                                      

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  

                                                                                                                                                                

                 

                                                                                                                                                                                            

 

                                 

                           

                                                                                                   

                                                                                                   

                                                                                                                        

                                                                                                                       

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                                            

                           





                                                          





       

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              

                                                                                                                                 

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                                                                                                                                      

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                                                                                                                                        

                                      

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                                                                                                                              

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                                                                                                           

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                                                                                                                                                                                                                                                                                     

                                                                                               

                     

                                                                                                                     

                                                                                                                                                                                                                                                                

                                                                                                                                                           

                                

 

                                                                                                                                                                              

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                                                                                                                                                                                                                         

        





                                                                                                                            





                                               

                             

                                                                                                                                                                                               

                                                                                        

                                                                                         

                                       

                                                                                                                                                                                                                

 

                                                              

                                                                                                                                                                  



                                                                                   

 



                                                                                                                             

                                                                                                                                

                                                                          

                                                                                                                                                          



                                   

                                                                                                                                                            

                                                   

                                                            

                                                                                                     

                                                                                                                                                                                                                                                                                          





 

   

 

 

 

 

  

   

   

   

   

   

                

                                                                    

      



                                

                                    

                               

                                                

 

            

                                                                                                                                          

 



         

                                    

                                                                                                            

                                                                                                              

      

                                                                                                                                                                                                                                                    

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                                                                                                                                                                                                                                                                    

                                                                                                                  

                                                                                                                   

         

                                                                                                                                                                                                                    

                                                                                                                                                                                                                         

      

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                                                                                                                                                                                                  

                                                                                                        

                                                                              

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                                    



                                                                                                                                                                       

                                                                                                                                                                                                                              

                                                                                                                                                                                                                                                                  

                                       

                                                                                                                                                     

                                                                                                                                                                                                                                

                                                                                                   

                                     

                      





  



 

 

 



 



    

         

        

 

                          

                                                                                                                                 

                  

                                                                           

                                  



                      

               



                                                              

 

      

         

                                                                                                                                        

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                                                                                                                                           

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                                                                      

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                                                                                                  

    



                                                                                                   

 



                                                                                   

                    

                                  

                                                                  

                  

           

     



           

                          

                                                                                                                                                                                                     

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                        

      



                                                   

                                         







  











                       

                           





                                 

                   





                         

                                                                                                                                                                 



                            

                                       





 

     

 

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                            

                                                                                                                

                                                                                                                                       

                                                                                                                                                               

                                                 

               



                                                                                                                                                                   

                                





                                                   

                  

                                  

 

                                                                                                      

                                

                                                                                                                                                   

                                               

               

            

                                                                                                



  

      

                    

                                                                                                   

                                                                       

     

                                                    

 



  

                 



                                                              

                       

         

                                                                                            





                            

                                                                      

      

                      

                                                                 





                 

                

      

   

                         

                                                             

                                                       

                                                                            

                                                       

                  

                                                                  





     







   

   

   

                        

          

                                                        

                                              

   

        

                                                                                                    



                                                          

                                                                  

    

                                                                                            

      



 



 

      

  

                                               



 



 

 



                                              



                               

                  



  

























 





 





 





 

















 





 





  

 



  





 

 

 

  





 

  



  





  



 

  





 



 



 

 

 





 

 



 





 



  

                                                  



                 

                                                                                                                    

                                        

                                  

                                                                                          

                                                    

                                          

                     



                                              

                                                                                                                                                          

       

                      

                                                                                                                                                                                                                     

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   

                                   

                                                                                         

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                                         

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                                                                                                                                                       



                                             

                                                                                     

                                              

                                 

                                              

                                                                                                                                             

    

     

                





                                                                                                                          

                          

                             



                                                                

                                     



                                                     

                 

 



                                                          

                                                                                

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                                                   

                                                                                                                    

                                                                                                                                                                                              

          

                                          

                                                                                      

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                                                

                       



                                                



                                                                       

                                

 

                                                                      

                       



                                                          

                                   

                                                 

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                 

                                                                                                                                      

                      

                                                           

                                                                                                                                                            

                                     



                                                

   

  



 

                                                  

             





                                



 

     

  





  

  

                      

                                                                                                  



   

  





      

      

      

   



                                                                                                                                                                   







      

      

      

                                                                   

                                                                                   

                   

                               



                                                                                                                  

       



                                     

                                                                  

             

                                                                                                                      

            



                                                           



      



                                                                                                    

                                                     

                                                

                                                                                                            

                                                 

                                                            

                                                                                             

                                                                                 

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             



 

                              

                                                                                                                    

                                                

                                   

     

          

       



                         

             

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                                                                                                                                                                           

                                                            

                                                 

      

 



 





 





            











                                                                                

                                                                                                                                                         

                                                

                                                                                                                                                                                                                           

                            

 

  

   









   



                

  

                          

                                       



                          

       

                                  



                                                                                                                   

                         







 



                                                                   







                                                                                                             

                       

                                                                                                                                            

         

                     

                                                                                                                                      

                                                     

                                                                                                                                                         

                      

                                                                                          

                                                                                                                                                  

                              

                             



  

  

  



    













 



  



  





    

  

  

  

  

   

  

  

  

  

   

  

  

  

  

  

  

  

  

    

                





                                                                                        

             

                                                                                             

                                                                                             

                                                                                                                                                

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                                                                                            

      

                                              

                 

                                            



                                                            

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               

                                                                 

                                                                                                 

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                                                                                                                                                                                                                

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                                                        

                                                      

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                                                      

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                           

                                                                          

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                           

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

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                                                                          

                                                                           

                                                                          

                                                                           

                                                                         

                                                                            

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                                                                          

                                                                           

                                                                          

                                                                          

                                                                            

                                                                          

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                                                                             

                                                                          

                                                                           

                                                                           

                                                                          

                                                                          

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                                                                          

                                                                          

                                                                          

                                                                             

                                                                          

                                                                           

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                                                                          

                                                                            

                                                                           

                                                                          

                                                                           

                                                                          

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                                                                          

                                                                             

                                                                           

                                                                           

                                                                          

                                                                          

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                                                                          

                                                                           

                                                                          

                                                                          

                                                                          

                                                                             

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                                                                            

                                                                           

                                                                          

                                                                          

                                                                           

                                                                          

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                                                                           

                                                                          

                                                                           

                                                                            

                                                                            

                                                                           

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                                                                          

                                                                            

                                                                          

                                                                          

                                                                          

                                                                           

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                                                                              

                                                                           

                                                                          

                                                                           

                                                                           

                                                                                 

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                                                                          

                                                                              

                                                                          

                                                                          

                                                                          

                                                                           

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                                                                           

                                                                          

                                                                          

                                                                          

                                                                          

                                                                           

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                                                                            

                                                                          

                                                                           

                                                                            

                                                                             

                                                                           

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                                                                           

                                                                          

                                                                              

                                                                           

                                                                            

                                                                          

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                                                                           

                                                                           

                                                                           

                                                                            

                                                                            

                                                                           

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                           

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                                                        

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                

                                                                          

                                                                               

                                                                                

                                                                          

                                                                             

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                                                                           

                                                                           

                                                                             

                                                                          

                                                                           

                                                                            

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                                

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                                        

                                                                           

                                                                           

                                                                          

                                                                          

                                                                             

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                           

                                                                            

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                                                                          

                                                                           

                                                                           

                                                                             

                                                                            

                                                                          

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                                                                          

                                                                          

                                                                           

                                                                            

                                                                           

                                                                          

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                                                                          

                                                                           

                                                                          

                                                                           

                                                                           

                                                                             

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                            

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                                                                           

                                                                           

                                                                           

                                                                           

                                                                            

                                                                           

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                                                                          

                                                                            

                                                                             

                                                                          

                                                                           

                                                                          

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                                                                            

                                                                               

                                                                           

                                                                           

                                                                                 

                                                                             

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                                                                          

                                                                          

                                                                          

                                                                             

                                                                         

                                                                          

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                                                                          

                                                                          

                                                                           

                                                                           

                                                                            

                                                                          

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                   

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                                                     

                                                                           

                                                                          

                                                                            

                                                                           

                                                                          

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

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                                                                          

                                                                           

                                                                           

                                                                          

                                                                           

                                                                           

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                                                                           

                                                                          

                                                                            

                                                                             

                                                                           

                                                                          

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                                                                             

                                                                          

                                                                           

                                                                          

                                                                           

                                                                          

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                                                                          

                                                                             

                                                                          

                                                                           

                                                                          

                                                                           

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                                                                            

                                                                          

                                                                            

                                                                            

                                                                          

                                                                          

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                                                                          

                                                                           

                                                                           

                                                                           

                                                                          

                                                                          

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                                                                            

                                                                           

                                                                           

                                                                           

                                                                          

                                                                          

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                                                                               

                                                                          

                                                                             

                                                                           

                                                                             

                                                                          

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                            

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                                     

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                                   

                                                                          

                                                                             

                                                                            

                                                                          

                                                                          

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                                                                             

                                                                           

                                                                           

                                                                            

                                                                            

                                                                          

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                                                                          

                                                                           

                                                                           

                                                                          

                                                                          

                                                                           

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                                                                          

                                                                           

                                                                          

                                                                          

                                                                          

                                                                           

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                                                                          

                                                                           

                                                                          

                                                                            

                                                                           

                                                                          

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                                                                          

                                                                            

                                                                          

                                                                           

                                                                           

                                                                           

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                                                                            

                                                                           

                                                                          

                                                                           

                                                                          

                                                                           

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                                                                          

                                                                           

                                                                           

                                                                         

                                                                          

                                                                            

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                                                                           

                                                                          

                                                                           

                                                                           

                                                                          

                                                                              

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                                                                            

                                                                           

                                                                           

                                                                          

                                                                          

                                                                              

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                                                                          

                                                                           

                                                                                 

                                                                          

                                                                          

                                                                            

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                                                                            

                                                                          

                                                                          

                                                                            

                                                                          

                                                                          

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                                                                          

                                                                            

                                                                          

                                                                          

                                                                           

                                                                          

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                                                                            

                                                                          

                                                                           

                                                                           

                                                                          

                                                                          

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                                                                            

                                                                             

                                                                           

                                                                          

                                                                         

                                                                           

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                                                                           

                                                                          

                                                                          

                                                                           

                                                                          

                                                                          

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                                                                             

                                                                          

                                                                           

                                                                          

                                                                             

                                                                            

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                                                                          

                                                                          

                                                                          

                                                                          

                                                                          

                                                                                  

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                                                                              

                                                                           

                                                                          

                                                                          

                                                                           

                                                                          

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                                                                          

                                                                          

                                                                         

                                                                          

                                                                             

                                                                            

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

                                                                              

                                                                          

                                                                            

                                                                            

                                                                          

                                                                         

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                                                                            

                                                                          

                                                                          

                                                                          

                                                                         

                                                                          

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                                                           

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                                                          

                                                          