If You've Never Had COVID, Should You Relax or Worry?

BY MARCIA FRELLICK WEBMD HEALTH NEWS

If you're among those people in the United States who never had COVID-19, how should you think about your risk? According to the CDC, more than half the people in the U.S. are in the nevergot-COVID-19 category. The CDC estimates that by the end of January, 43.4% in the U.S. had antibodies to the coronavirus triggered by infection, not by vaccination -- suggesting that nearly 60% of people have never been infected. Now mask mandates are lifting, and daily case and death numbers are plunging. According to the New York Timestracker, new cases are down 51% for the past 2 weeks, and deaths have fallen 30% in that period. So as those who have so far escaped the virus venture out into reopened environments, should they worry more or less about risk than people who were infected before them? Some experts weigh in with caution against feeling invincible.

No ‘Suit of Armor’ William Schaffner, MD, an infectious disease expert at Vanderbilt University School of Medicine in Nashville, says science has not been able to determine why some people have been able to be stay COVID-19-free when the virus was raging and exposure was widespread. He says it's important to remember that though some people think they have never had COVID-19, they may have had the disease without symptoms or blamed mild symptoms on something else. "People may have conceivably -- but we can't define them yet — different capacities to ward off viruses or bacteria," Schaffner says. Could it be that some people have a better immune system or some set of genes, or a particular environmental reason they are less likely to be affected by an infectious disease? "We can't define that in 2022 medicine, but it could be," he says. More is known about why people get sicker than others with the same COVID19 exposure. "They're more likely to get seriously ill if they have a list of predisposing conditions — if they're older, if they're frail, if they have underlying illness or are obese. All of those things clearly impair the body's response to virus," Schaffner says. He warns those who have never been infected, though, not to assume they have "a suit of armor." All should continue to follow guidance on getting vaccinated, and those vaccinated should continue to get boosted, Schaffner says. "Clearly, the data show that if you are vaccinated and boosted, you're protected much more securely against severe disease," he says. If the “never-COVIDs” get a respiratory infection, they should still get tested for COVID-19, Schaffner says. He says that while both vaccines and previous infection offer protection, how long that protection lasts is not yet known. "We have to stay tuned," Schaffner says. "There may be a recommendation in the future to get a booster annually or something like that. We need to be open to those down the road." Amesh Adalja, MD, a senior scholar at the Johns Hopkins Center for Health Security in Baltimore, says it's unclear why some people have been able to avoid COVID-19 There are probably many reasons for this, he says, and they involve how each person’s immune system reacts differently. That itself is probably based in differences in our genes. He agrees, also, that many of us were likely infected and never knew it. Still, he says, this isn't the time to get overconfident with risk-taking where COVID-19 is concerned. "People who have not knowingly been infected with COVID should be vaccinated, and after that, be assured that they are protected against serious disease

continued on page 26

You may be eligible for COVID-19 Treatment

People who have tested positive for COVID-19 may be able to receive outpatient treatment to help symptoms and avoid hospitalization. Treatment works best if you begin it soon after you start feeling symptoms, so get tested right away. Monoclonal antibody treatment is a one-time IV or injection to help fight COVID-19 while your immune system produces its own antibodies. Oral antiviral pills are taken for five days and helps stop the virus and keeps it from replicating, which reduces the amount of virus in your body. There are currently two authorized pills - paxlovid and molunpiravir. Both monoclonal antibody and oral antiviral treatments can reduce your risk of becoming sick from COVID-19 and avoid hospitalization.

COVID-19 treatments are not a substitute for vaccination. COVID-19 vaccination and booster shots remain the best protection against getting severely sick due to COVID-19. If you have COVID-19 symptoms, or if you have tested positive, talk to your doctor, or call 212-COVID19 (212-268-4319).