Decellularized Fish Skin Technology

Kerecis

® Omega3

What Types of Wounds Are Suitable? Contraindications

■ Diabetic ulcers

■ Chronic vascular ulcers

■ Venous ulcers

■ Trauma wounds (including abrasions, lacerations and skin tears)

■ Acute surgical wounds (including debridement, amputation and donor sites)

■ Surgical wounds (dehiscence or failed healing after surgery)

■ Imminent failure of split thickness skin graft

■ Post-injection necrosis

■ Contraindicated in patients with a known allergy or other sensitivity to fish

Points to Consider

■ Remove necrotic tissue under the graft prior to product application

■ Remove exudate and control bleeding before application

■ Do not reuse or re-sterilize

■ Discard unused portions of the product

■ Do not use after printed expiration date

■ Product is sterile if package is unopened and undamaged

■ Do not use device if package seal has been broken or if handling has caused damage or contamination

Decellularized Fish Skin Technology

Kerecis® Omega3

What Is the Evidence?

Kerecis® Omega3 has had numerous trials supporting its efficacy in healing rates. A study regarding the use of Kerecis® Omega3 on diabetic foot ulcers (DFU) showed significantly higher healing rates compared to DFUs treated by fibrocol, a collagen-alginate dressing.

Efficacy Quality of Wound Healing

■ Other tissue transplant products that are based on tissues of human and porcine origin are not ideal substitutes because of the heavy processing needed to eliminate the risk of disease transmission. This harsh, anti-viral treatment removes most of the material’s natural components, making it too dissimilar to human skin.

Kerecis® Omega3 is not subject to this treatment, leaving a more naturally intact product

■ Kerecis® has demonstrated its proficiency in creating lipidcontaining tissue matrices from fish skin, and it has been shown that the material is safe, non-toxic and structurally sound

■ A recent publication of an RCT by Lullove et. al (2022) shows 106% more healed wounds at 12 weeks compared to Collagen-Algenate dressing, a statistically significant finding

■ Compared to mammalian-based skin substitutes, Kerecis® Omega3 offers improved economics and clinical performance, as well as reduced disease transfer risk

■ Mammalian tissue carries the risk of disease transmission to humans. This is not a risk with Kerecis® Omega3

■ Kerecis® Omega3 fish skin contains lipids and proteins that, in a concentrated form, help the body regenerate damaged tissue

Costs

■ Kerecis® is focused on developing medical device applications with a predicated high return on investment and a low to medium cost of development. The company focuses exclusively on tissue regeneration and maintenance, utilizing its core Omega3 fish skin technology.

“These results will help guide clinicians to make decisions that positively impact both their patients’ outcomes and treatment costs.”

“The standard of care for treating DFUs is constantly improving... We compared the fish skin to an advanced collagen-alginate dressing to represent current alternatives. We wanted to compare it to more than just a simple wet-to-dry gauze or other, older methods.”

"The Kerecis™ Omega3 Wound matrix is a decellularized skin matrix derived from fish skin and represents an innovative concept to achieve wound healing... in this study (it) represented an effective treatment option in 25 complicated wounds."