ADVERTISEMENT FOR A JRF POSITION AT DR. REDDY’S INSTITUTE OF LIFE SCIENCES, HYDERABAD PROJECT TITLE Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma models. FUNDING AGENCY : DBT POSITION: Junior Research Fellow with any one of the following:
Post Graduate Degree in Basic Science with NET qualification Graduate Degree in Professional Course with NET qualification Post Graduate Degree in Professional Course
NETs accepted: CSIR-NET including LS; GATE, JAM, GPAT, BET, JEST, JGEEBILS, ICMR-JRF and ICAR- AICE. Candidates with a keen interest in basic science research and prior hands-on experience with molecular biology and zebrafish are preferred. Experience with CRISPR would be an additional advantage. A possibility of Ph.D. enrolment exists, but is not guaranteed. EMOLUMENTS AND DURATION Rs. 25000+HRA per month Project duration: Until April 9, 2020 Appointment will be renewed yearly contingent on performance. DEADLINE: 25th June, 2018 PROJECT SUMMARY The zebrafish Danio rerio can be a useful model to study human biology and disease. Tyrosine kinases are a family of proteins with significant roles in cell growth and proliferation, and are major molecular targets for cancer therapy. We have shown that human tyrosine kinases are well-conserved in zebrafish. This Indo-Spanish collaborative project aims to explore the effects of tyrosine kinase inhibition using small molecules, and tyrosine kinase gene deletion or overexpression in zebrafish. i. Identification of phenotypic and molecular endpoints of tyrosine kinase inhibition (using approved TKIs or CRISPR-mediated gene deletion) in wild type zebrafish. ii. Evaluation of the effect of tyrosine kinase inhibition in transgenic zebrafish overexpressing selected human tyrosine kinases with glioma phenotypes. iii. Genomic profiling of wild type and transgenic zebrafish. Qualified and interested candidates may send their curriculum vitae by e-mail to hr@drils.org on or before deadline. mention in the subject line of the mail the following code: Zebrafish - Biology. Selected candidates will be called for a personal interview to Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad. Candidates will not be reimbursed for Travel for the Interview, if short listed.