Iris
Substrates for Life Sciences From Grams to Multi-Ton Lots
B i o t e c h G m bH
New: Preloaded Resins for Synthesis of Peptide Amides Used for efficient and economic synthesis of bulk peptide APIs The Technology:
The Advantages:
Side chain attachment of amino acids and peptides on highly acid sensitive resins. ÎÎ NO amide linker is involved and therefore no linker typical side reactions and contamination thereof. ÎÎ Protected peptide acids & amides can be obtained in high yield and purity, because cleavage from the resins can be carried out in the presence of TFA sensitive protecting groups of the t-butyl type. ÎÎ Any intermediate can be cleaved as protected peptide fragment, enabling a very easy in process control through HPLC. ÎÎ This is especially useful during the optimization of any large scale synthesis!
This concept can be extended to any peptide acid&amide with side chain functions. References: ff K. Barlos et al. WO 2013/098802 A2. ff K. Barlos, D. Gatos et al., Int. J. Peptide and Protein Res. 1991; 38: 555-561. ff K. Barlos and D. Gatos, in Fmoc solid phase peptide synthesis, edit. W.C. Chan and P. D. White, Oxford University Press, 2000. ff Attachment of Histidine, Histamine and Urocanic acid to Resins of the Trityl-Type. Eleftheriou, S.; Gatos, D.; Panagopoulos, A.; Stathopoulos, S.; Barlos, K.; Tetrahedron Letters 1999; 40(14): 2825- 2828. ff G. Sabatino et al. Tetrahedron Letters 1999; 40: 809-812. ff E. Atherton et al. US 7,691,968 B2.
3763 / 0314
ff F. Albericio et al. WO 2008/040536 A1.
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