Iris
Biotech
ÎÎ They have proven to be outstandingly useful for the synthesis of primary, secondary, and tertiary amides, of depsipeptides and oligoesters, and in particular of difficult peptide sequences. ÎÎ Chemical ligation and other difficult conjugates can be synthesized with high yield and purity. ÎÎ Benzotriazoles (Bt) are a superior alternative to formerly used NHS (N-hydroxysuccinimide) and Pfp (pentafluorophenol) esters. ÎÎ Benzotriazoles (Bt) have a significant difference to N-hydroxybenzotriazoles (HOBt)! The latter ones are being prepared with potentially explosive HOBt and are rather instable, while Benzotriazole (Bt) compounds are very stable and not hazardous, at all.
Custom Synthesis Service
Boc
OH
H N
(S)
(S)
O
O
H2N
N N
N
drug Synthesis of Sophisticated Benzotriazole Activated Compounds for Conjugation at Client’s Lab
R'' O
R'
link
OH O
Synthesis of Protein and
Synthesis of Difficult Peptide Sequences
Antibody Drug Conjugates
or Depsipeptides
With our know-how we can carry out custom synthesis of difficult compounds. Send us your inquiry! References: ff Synthesis and antibacterial evaluation of amino acid–antibiotic conjugates; Mohamed A. Ibrahim, Siva S. Panda, Antoinette S. Birs, Juan C. Serrano, Claudio F. Gonzalez, Khalid A. Alamry, Alan R. Katritzky; Bioorganic & Medicinal Chemistry Letters 2014; 24: 1856-1861. ff N-Acylbenzotriazoles: neutral acylating reagents for the preparation of primary, secondary, and tertiary amides; Alan R. Katritzky, Hai-Ying He, Kazuyuki Suzuki; J. Org. Chem. 2000; 65(24): 8210-3. ff Total synthesis of cyclic heptapeptide Rolloamide; Mirna El Khatib, Mohamed Elagawany, Eray Çalis-kan, Emily Faith Davis, Hassan M. Faidallah, Said A. El-feky, Alan R. Katritzky; Chem. Commun. 2013; 49: 2631. ff Microwave-Assisted Solid-Phase Peptide Synthesis Utilizing N-Fmoc-Protected (alpha-aminoacyl)benzotriazoles; Alan R. Katritzky, Niveen M. Khashab, Megumi Yoshioka, Danniebelle N. Haase, Krista R. Wilson, Jodie V. Johnson, Alfred Chung, Carrie Haskell-Luevano; Chem. Biol Drug. Des. 2007; 70: 465468.
ff Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters; Ilker Avan, Srinivasa R. Tala, Peter J. Steel, Alan R. Katritzky; J. Org. Chem. 2011; 76: 4884–4893. dx.doi.org/10.1021/jo200174j. ff Chemical Ligation of S-Acylated Cysteine Peptides to Form Native Peptides via 5-, 11-, and 14-Membered Cyclic Transition States; Alan R. Katritzky, Srinivasa R. Tala, Nader E. Abo-Dya, Tarek S. Ibrahim, Said A. El-Feky, Kapil Gyanda, Keyur M. Pandya; J. Org. Chem. 2011; 76: 85-96; DOI: 10.1021/jo1015757. ff Benzotriazole-Assisted Solid-Phase Assembly of Leu-Enkephalin, Amyloid segment 34-42, and other “Difficult” Peptide Sequences; Alan R. Katritzky, Danniebelle N. Haase, Jodie V. Johnson, Alfred Chung; J. Org. Chem. 2009; 74: 2028-2032; DOI: 10.1021/jo8026214. ff The Efficient Preparation of Di- and Tripeptides by Coupling N-(Cbz- or Fmoc-alpha-aminoacyl)benzotriazoles with Unprotected Amino Acids; Alan R. Katritzky, Parul Angrish, Kazuyuki Suzuki; Synthesis 2006; 3: 411–424; DOI: 10.1055/s-2006-926287.
ff N-Tfa- and N-Fmoc-(alpha-aminoacyl)benzotriazoles as Chiral C-Acylating Reagents under Friedel-Crafts Reaction Conditions; Alan R. Katritzky, Rong Jiang, Kazuyuki Suzuki; J. Org. Chem. 2005; 70: 4993-5000.
Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
From Grams to Multi-Ton Lots
Available N-alpha-Protected Amino Acids: Boc-Protected Amino Acids Article No.
BAAX001 Boc-L-Ala-Bt N-alpha-t-Butyloxycarbonyl-L-alanine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C14H18N4O3 MOLECULAR WEIGHT: 290,32 g/mole SYNONYMS: (S)-t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxopropan-2-ylcarbamate
BAAX016 Boc-L-Arg(Tos)-Bt
O
N
O
N
O
HN
Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
€ 300,00
5g
€ 1200,00
BAAX016.0001
1g
€ 450,00
BAAX016.0005
5g
€ 1750,00
BAAX007.0001
1g
€ 300,00
BAAX007.0005
5g
€ 1200,00
BAAX015.0001
1g
€ 375,00
BAAX015.0005
5g
€ 1450,00
O
O N N
O
N
O NH2 O
H N
O
N
(S)
N
O
N
O O
O
H N
O
N
S
H N
O
please inquire! N
(R)
O
N
(S)
N
O
1g
€ 375,00
BAAX014.0005
5g
€ 1450,00
BAAX008.0001
1g
€ 300,00
BAAX008.0005
5g
€ 1200,00
N
O (S)
N N
O
O
BAAX014.0001
O
H N
O
N
O
O
BAAX008 Boc-L-Gln-Bt N-alpha-t-Butyloxycarbonyl-L-glutamine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C16H21N5O4 MOLECULAR WEIGHT: 347,37 g/mole SYNONYMS: (S)-t-butyl 4-amino-1-(1H-benzo[d][1,2,3]triazol-1-yl)1,5-dioxopentan-2-ylcarbamate
1g
BAAX001.0005
S
(S)
N-alpha-t-Butyloxycarbonyl-L-aspartic acid-alpha-(1H-benzo[d][1,2,3]triazol1-yl), beta-benzyl diester FORMULA: C22H24N4O5 MOLECULAR WEIGHT: 424,45 g/mole SYNONYMS: (S)-benzyl 4-(1H-benzo[d][1,2,3]triazol-1-yl)3-(tert-butoxycarbonylamino)-4-oxobutanoate
N-alpha-t-Butyloxycarbonyl-L-glutamic acid-alpha-(1H-benzo[d][1,2,3]triazol1-yl), gamma-benzyl diester FORMULA: C23H26N4O5 MOLECULAR WEIGHT: 438,48 g/mole SYNONYMS: (S)-benzyl 5-(1H-benzo[d][1,2,3]triazol-1-yl)4-(tert-butoxycarbonylamino)-5-oxopentanoate
O N H
H N
O
BAAX015 Boc-L-Asp(Bzl)-Bt
BAAX014 Boc-L-Glu(Bzl)-Bt
N
NH
BAAX007 Boc-L-Asn-Bt
N-alpha-t-Butyloxycarbonyl-S-benzyl-L-cysteine (1H-benzo[d][1,2,3]triazol1-yl) ester FORMULA: C21H24N4O3S MOLECULAR WEIGHT: 412,51 g/mole SYNONYMS: (R)-tert-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-(benzylthio)1-oxopropan-2-ylcarbamate
N
(S)
BAAX001.0001
N
O
H N
N-alpha-t-Butyloxycarbonyl-N-gamma-4-toluolsulfonyl-L-arginine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C24H31N7O5S MOLECULAR WEIGHT: 529,61 g/mole SYNONYMS: (S)-tert-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo5-(3-tosylguanidino)pentan-2-ylcarbamate
BAAX019 Boc-L-Cys(Bzl)-Bt
N
(S)
O
N-alpha-t-Butyloxycarbonyl-L-asparagine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C15H19N5O4 MOLECULAR WEIGHT: 333,34 g/mole SYNONYMS: (S)-t-butyl 4-amino-1-(1H-benzo[d][1,2,3]triazol-1-yl)-1,4-dioxobutan2-ylcarbamate
O
H N
Quantity Price
N
NH2
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
Iris
Biotech Article No.
BAAX009 Boc-Gly-Bt N-alpha-t-Butyloxycarbonyl-glycine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C13H16N4O3 MOLECULAR WEIGHT: 276,29 g/mole SYNONYMS: t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxoethylcarbamate
O
H N
O
N
N-alpha-t-Butyloxycarbonyl-N-im-benzyl-L-histidine (1H-benzo[d][1,2,3] triazol-1-yl) ester FORMULA: C24H26N6O3 MOLECULAR WEIGHT: 446,5 g/mole SYNONYMS: (S)-tert-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-(1-benzyl-1Himidazol-4-yl)-1-oxopropan-2-ylcarbamate
N
N
O
H N
O O
(S)
N
(S)
N
N
(S)
N
O
N
(S)
N
O
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
€ 1200,00
BAAX004.0001
1g
€ 300,00
BAAX004.0005
5g
€ 1200,00
BAAX013.0001
1g
€ 375,00
BAAX013.0005
5g
€ 1450,00
BAAX005.0001
1g
€ 300,00
BAAX005.0005
5g
€ 1200,00
BAAX006.0001
1g
€ 300,00
BAAX006.0005
5g
€ 1200,00
BAAX010.0001
1g
€ 300,00
BAAX010.0005
5g
€ 1200,00
N
O
O
H N
O
N
(S)
N
O
N
SMe
O
H N
O
(S)
N N
O
N
BAAX010 Boc-L-Pro-Bt
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
€ 300,00
5g
O
HN
BAAX006 Boc-L-Phe-Bt
Internet: www.iris-biotech.de Email: info@iris-biotech.de
1g
BAAX003.0005
N
O
H N
O
BAAX003.0001
N
O
H N
O
BAAX005 Boc-L-Met-Bt
N-alpha-t-Butyloxycarbonyl-L-proline (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C16H20N4O3 MOLECULAR WEIGHT: 316,36 g/mole SYNONYMS: (S)-t-butyl 2-(1H-benzo[d][1,2,3]triazole-1-carbonyl)pyrrolidine1-carboxylate
€ 1200,00
N
N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C25H31N5O5 MOLECULAR WEIGHT: 481,54 g/mole SYNONYMS: (S)-tert-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)6-(benzyloxycarbonylamino)-1-oxohexan-2-ylcarbamate
N-alpha-t-Butyloxycarbonyl-L-phenylalanine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C20H22N4O3 MOLECULAR WEIGHT: 366,41 g/mole SYNONYMS: (S)-t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan2-ylcarbamate
5g
N
BAAX013 Boc-L-Lys(Z)-Bt
N-alpha-t-Butyloxycarbonyl-L-methionine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C16H22N4O3S MOLECULAR WEIGHT: 350,44 g/mole SYNONYMS: (S)-t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-4-(methylthio)1-oxobutan-2-ylcarbamate
BAAX009.0005
please inquire!
O
BAAX004 Boc-L-Leu-Bt N-alpha-t-Butyloxycarbonyl-L-leucine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C17H24N4O3 MOLECULAR WEIGHT: 332,4 g/mole SYNONYMS: (S)-t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-4-methyl-1-oxopentan2-ylcarbamate
€ 300,00
N
(S)
BAAX003 Boc-L-Ile-Bt N-alpha-t-Butyloxycarbonyl-L-isoleucine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C17H24N4O3 MOLECULAR WEIGHT: 332,4 g/mole SYNONYMS: t-butyl (2S,3S)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl1-oxopentan-2-ylcarbamate
1g
N
O
H N
O
BAAX009.0001 N
O
BAAX018 Boc-L-His(Bzl)-Bt
Quantity Price
O
N O
O
(S)
N N
N
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
From Grams to Multi-Ton Lots Article No.
BAAX012 Boc-L-Ser(Bzl)-Bt N-alpha-t-Butyloxycarbonyl-O-benzyl-L-serine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C21H24N4O4 MOLECULAR WEIGHT: 396,44 g/mole SYNONYMS: (S)-t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-benzyloxy-1-oxopropan2-ylcarbamate
O
N
O
N
(S) (R)
O
BAAX017 Boc-L-Trp(For)-Bt
N
O
O
O
N
O
H N
O
N-alpha-t-Butyloxycarbonyl-O-benzyl-L-threonine (1H-benzo[d][1,2,3]triazol1-yl) ester FORMULA: C22H26N4O4 MOLECULAR WEIGHT: 410,47 g/mole SYNONYMS: t-butyl (2S,3R)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-benzyloxy1-oxobutan-2-ylcarbamate
HN
N
(S)
1g
€ 375,00
BAAX012.0005
5g
€ 1450,00
BAAX020.0001
1g
€ 375,00
BAAX020.0005
5g
€ 1450,00
BAAX017.0001
1g
€ 450,00
BAAX017.0005
5g
€ 1750,00
BAAX011.0001
1g
€ 375,00
BAAX011.0005
5g
€ 1450,00
BAAX002.0001
1g
€ 300,00
BAAX002.0005
5g
€ 1200,00
N
N H
O O
H N
O
N
(S)
N
O
N
O
BAAX002 Boc-L-Val-Bt N-alpha-t-Butyloxycarbonyl-L-valine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C16H22N4O3 MOLECULAR WEIGHT: 318,37 g/mole SYNONYMS: (S)-t-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan2-ylcarbamate
BAAX012.0001
N
O
N
BAAX011 Boc-L-Tyr(Bzl)-Bt N-alpha-t-Butyloxycarbonyl-O-benzyl-L-tyrosine (1H-benzo[d][1,2,3]triazol1-yl) ester FORMULA: C27H28N4O4 MOLECULAR WEIGHT: 472,54 g/mole SYNONYMS: (S)-tert-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-(4-(benzyloxy) phenyl)-1-oxopropan-2-ylcarbamate
N
(S)
BAAX020 Boc-L-Thr(Bzl)-Bt
N-alpha-t-Butyloxycarbonyl-N‘-formyl-L-tryptophane (1H-benzo[d][1,2,3] triazol-1-yl) ester FORMULA: C23H23N5O4 MOLECULAR WEIGHT: 433,46 g/mole SYNONYMS: (S)-tert-butyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-(1-formyl-1H-indol3-yl)-1-oxopropan-2-ylcarbamate
O
H N
O
Quantity Price
O
H N
O
N
(S)
N
O
N
Fmoc-Protected Amino Acids Article No.
FAAX020 Fmoc-L-Ala-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-alanine (1H-benzo[d][1,2,3] triazol-1-yl) ester FORMULA: C24H20N4O3 MOLECULAR WEIGHT: 412,44 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)1-oxopropan-2-ylcarbamate
O
H N
O
Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
H N
O
N
O
1g
€ 300,00
FAAX020.0005
5g
€ 1200,00
FAAX035.0001
1g
€ 450,00
FAAX035.0005
5g
€ 1750,00
N
O (S)
FAAX020.0001
N
(S)
O
FAAX035 Fmoc-L-Arg(Pbf)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-N‘-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C40H43N7O6S MOLECULAR WEIGHT: 749,88 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino) pentan-2-ylcarbamate
Quantity Price
N N
N NH
N H
N H
O
O
S O
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
Iris
Biotech Article No.
FAAX036 Fmoc-L-Asn(Trt)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-beta-trityl-L-asparagine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C44H35NO4 MOLECULAR WEIGHT: 697,78 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)1,4-dioxo-4-(tritylamino)butan-2-ylcarbamate
N
(S)
N
O NH
O
H N
O
N
O
Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
€ 1450,00
N
(R)
O
N
S
N
(S)
N
O
O
€ 375,00
FAAX033.0005
5g
€ 1450,00
please inquire! N N
O
O
N
NH
O
H N
N
H N
FAAX026.0001
1g
€ 300,00
FAAX026.0005
5g
€ 1200,00
N
O
O
1g
N
O (S)
O
FAAX033.0001
O
H N
O
N
O
H N
O
FAAX040 Fmoc-L-His(Boc)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-im-(t-butyloxycarbonyl)L-histidine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C32H30N6O5 MOLECULAR WEIGHT: 578,62 g/mole SYNONYMS: (S)-tert-butyl 4-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)3-(1H-benzo[d][1,2,3]triazol-1-yl)-3-oxopropyl)-1H-imidazole-1-carboxylate
€ 375,00
5g
please inquire!
O
H N
O
FAAX026 Fmoc-Gly-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-glycine (1H-benzo[d][1,2,3]triazol1-yl) ester CAS-NO: 1082989-49-8 FORMULA: C23H18N4O3 MOLECULAR WEIGHT: 398,41 g/mole SYNONYMS: (9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxoethylcarbamate
1g
FAAX032.0005
O
FAAX037 Fmoc-L-Gln(Trt)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-gamma-trityl-L-glutamine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C45H37N5O4 MOLECULAR WEIGHT: 711,81 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)1,5-dioxo-5-(tritylamino)pentan-2-ylcarbamate
FAAX032.0001
N
O
FAAX033 Fmoc-L-Glu(tBu)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic acid-gamma-t-butyl ester (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C30H30N4O5 MOLECULAR WEIGHT: 526,58 g/mole SYNONYMS: (S)-tert-butyl 4-(((9H-fluoren-9-yl)methoxy)carbonylamino)5-(1H-benzo[d][1,2,3]triazol-1-yl)-5-oxopentanoate
N
(S)
FAAX038 Fmoc-L-Cys(Trt)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-trityl-L-cysteine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C43H34N4O3S MOLECULAR WEIGHT: 686,82 g/mole SYNONYMS: (R)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo3-(tritylthio)propan-2-ylcarbamate
N
O
FAAX032 Fmoc-L-Asp(tBu)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid-alpha(1H-benzo[d][1,2,3]triazol-1-yl), beta-t-butyl diester FORMULA: C29H28N4O5 MOLECULAR WEIGHT: 512,56 g/mole SYNONYMS: (S)-tert-butyl 3-(((9H-fluoren-9-yl)methoxy)carbonylamino)4-(1H-benzo[d][1,2,3]triazol-1-yl)-4-oxobutanoate
please inquire!
O
H N
O
Quantity Price
N
please inquire!
O (S)
N N
O
N
N N O
O
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
From Grams to Multi-Ton Lots Article No.
FAAX022 Fmoc-L-Ile-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-isoleucine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C27H26N4O3 MOLECULAR WEIGHT: 454,52 g/mole SYNONYMS: (9H-fluoren-9-yl)methyl (2S,3S)-1-(1H-benzo[d][1,2,3]triazol-1-yl)3-methyl-1-oxopentan-2-ylcarbamate
O
H N
O O
(S)
N
(S)
N
O
H N
O
N
O
O N
(S)
N
O
HN
O
H N
O
N
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
1g
€ 300,00
FAAX023.0005
5g
€ 1200,00
FAAX031.0001
1g
€ 375,00
FAAX031.0005
5g
€ 1450
FAAX024.0001
1g
€ 300,00
FAAX024.0005
5g
€ 1200,00
FAAX025.0001
1g
€ 300,00
FAAX025.0005
5g
€ 1200,00
FAAX027.0001
1g
€ 300,00
FAAX027.0005
5g
€ 1200,00
FAAX029.0001
1g
€ 375,00
FAAX029.0005
5g
€ 1450,00
N
SMe
O
H N
O
N
(S)
N
O
N
O
N O
(S)
N
O
N
N
FAAX029 Fmoc-L-Ser(tBu)-Bt
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
FAAX023.0001
N
(S)
O
N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-proline (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 1155875-68-5 FORMULA: C26H22N4O3 MOLECULAR WEIGHT: 438,48 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 2-(1H-benzo[d][1,2,3]triazole-1-carbonyl) pyrrolidine-1-carboxylate
Internet: www.iris-biotech.de Email: info@iris-biotech.de
€ 1200,00
O
FAAX027 Fmoc-L-Pro-Bt
N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-serine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C28H28N4O4 MOLECULAR WEIGHT: 484,55 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)3-tert-butoxy-1-oxopropan-2-ylcarbamate
5g
O
FAAX025 Fmoc-L-Phe-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-phenylalanine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C30H24N4O3 MOLECULAR WEIGHT: 488,54 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo3-phenylpropan-2-ylcarbamate
FAAX022.0005
N
FAAX024 Fmoc-L-Met-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-methionine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C26H24N4O3S MOLECULAR WEIGHT: 472,56 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)4-(methylthio)-1-oxobutan-2-ylcarbamate
€ 300,00
N
FAAX031 Fmoc-L-Lys(Boc)-Bt H N
1g
N
(S)
O
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyloxycarbonylL-lysine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C32H35N5O5 MOLECULAR WEIGHT: 569,65 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)6-(t-butyloxycarbonylamino)-1-oxohexan-2-ylcarbamate
FAAX022.0001
N
FAAX023 Fmoc-L-Leu-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-leucine (1H-benzo[d][1,2,3]triazol1-yl) ester CAS-NO: 1072840-99-3 FORMULA: C27H26N4O3 MOLECULAR WEIGHT: 454,52 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)4-methyl-1-oxopentan-2-ylcarbamate
Quantity Price
O
H N
O
(S)
O
O
N N
N
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
Iris
Biotech Article No.
FAAX030 Fmoc-L-Thr(tBu)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-threonine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C29H30N4O4 MOLECULAR WEIGHT: 498,57 g/mole SYNONYMS: (9H-fluoren-9-yl)methyl (2S,3R)-1-(1H-benzo[d][1,2,3]triazol-1-yl)3-tert-butoxy-1-oxobutan-2-ylcarbamate
H N
O
(R)
O
N
O
H N
O
1g
€ 375,00
FAAX030.0005
5g
€ 1450,00
FAAX034.0001
1g
€ 450,00
FAAX034.0005
5g
€ 1750,00
FAAX028.0001
1g
€ 375,00
FAAX028.0005
5g
€ 1450,00
FAAX021.0001
1g
€ 300,00
FAAX021.0005
5g
€ 1200,00
N
O N
(S)
N
O O
FAAX030.0001 N
(S)
FAAX034 Fmoc-L-Trp(Boc)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-in-t-butyloxycarbonylL-tryptophane (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C37H33N5O5 MOLECULAR WEIGHT: 627,69 g/mole SYNONYMS: (S)-tert-butyl 3-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)3-(1H-benzo[d][1,2,3]triazol-1-yl)-3-oxopropyl)-1H-indole-1-carboxylate
O
Quantity Price
N
N O
FAAX028 Fmoc-L-Tyr(tBu)-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosine (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 1126433-42-8 FORMULA: C34H32N4O4 MOLECULAR WEIGHT: 560,64 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)3-(4-tert-butoxyphenyl)-1-oxopropan-2-ylcarbamate
O
H N
O
N
(S)
N
O
N
O
FAAX021 Fmoc-L-Val-Bt N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-valine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C26H24N4O3 MOLECULAR WEIGHT: 440,49 g/mole SYNONYMS: (S)-(9H-fluoren-9-yl)methyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)3-methyl-1-oxobutan-2-ylcarbamate
O
H N
O
N
(S)
N
O
N
Z-Protected Amino Acids Article No.
ZAAX040 Z-L-Ala-Bt N-alpha-Benzyloxycarbonyl-L-alanine (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 820239-42-7 FORMULA: C17H16N4O3 MOLECULAR WEIGHT: 324,33 g/mole SYNONYMS: (S)-benzyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxopropan2-ylcarbamate
O
H N
O
N-alpha-Benzyloxycarbonyl-L-asparagine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C18H17N5O4 MOLECULAR WEIGHT: 367,36 g/mole SYNONYMS: (S)-benzyl 4-amino-1-(1H-benzo[d][1,2,3]triazol-1-yl)-1,4-dioxobutan2-ylcarbamate
N
Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
(S)
N N
O O
1g
€ 300,00
ZAAX040.0005
5g
€ 1200,00
ZAAX048.0001
1g
€ 300,00
ZAAX048.0005
5g
€ 1200,00
N
O
H N
O
ZAAX040.0001
N
(S)
O
ZAAX048 Z-L-Asn-Bt
Quantity Price
N
NH2
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
From Grams to Multi-Ton Lots Article No.
ZAAX049 Z-L-Gln-Bt N-alpha-Benzyloxycarbonyl-L-glutamine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C19H19N5O4 MOLECULAR WEIGHT: 381,39 g/mole SYNONYMS: (S)-benzyl 4-amino-1-(1H-benzo[d][1,2,3]triazol-1-yl)-1,5-dioxopentan2-ylcarbamate
O
H N
O
N
(S)
N
O
O
O
N
O
O
(S)
N
(S)
N
ZAAX043 Z-L-Leu-Bt N-alpha-Benzyloxycarbonyl-L-leucine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C20H22N4O3 MOLECULAR WEIGHT: 366,41 g/mole SYNONYMS: (S)-benzyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-4-methyl1-oxopentan-2-ylcarbamate
N
O
O
N
(S)
N
O
Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
1g
€ 300,00
ZAAX046.0005
5g
€ 1200,00
ZAAX042.0001
1g
€ 300,00
ZAAX042.0005
5g
€ 1200,00
ZAAX043.0001
1g
€ 300,00
ZAAX043.0005
5g
€ 1200,00
ZAAX044.0001
1g
€ 300,00
ZAAX044.0005
5g
€ 1200,00
ZAAX045.0001
1g
€ 300,00
ZAAX045.0005
5g
€ 1200,00
ZAAX047.0001
1g
€ 300,00
ZAAX047.0005
5g
€ 1200,00
ZAAX041.0001
1g
€ 300,00
ZAAX041.0005
5g
€ 1200,00
N
O
H N
O
N
(S)
N
O
N
O
N O
(S)
N
O
N
N
ZAAX041 Z-L-Val-Bt N-alpha-Benzyloxycarbonyl-L-valine (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 820239-44-9 FORMULA: C19H20N4O3 MOLECULAR WEIGHT: 352,39 g/mole SYNONYMS: (S)-benzyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan2-ylcarbamate
ZAAX046.0001
SMe
ZAAX047 Z-L-Pro-Bt N-alpha-Benzyloxycarbonyl-L-proline (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C19H18N4O3 MOLECULAR WEIGHT: 350,37 g/mole SYNONYMS: (S)-benzyl 2-(1H-benzo[d][1,2,3]triazole-1-carbonyl)pyrrolidine1-carboxylate
€ 1200,00
N
O
H N
ZAAX045 Z-L-Phe-Bt N-alpha-Benzyloxycarbonyl-L-phenylalanine (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 769922-77-2 FORMULA: C23H20N4O3 MOLECULAR WEIGHT: 400,43 g/mole SYNONYMS: (S)-benzyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan2-ylcarbamate
N
(S)
ZAAX044 Z-L-Met-Bt N-alpha-Benzyloxycarbonyl-L-methionine (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C19H20N4O3S MOLECULAR WEIGHT: 384,45 g/mole SYNONYMS: (S)-benzyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-4-(methylthio)1-oxobutan-2-ylcarbamate
5g
N
O
H N
O
ZAAX049.0005
N
O
H N
O
€ 300,00
N
ZAAX042 Z-L-Ile-Bt N-alpha-Benzyloxycarbonyl-L-isoleucine (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 1072442-07-9 FORMULA: C20H22N4O3 MOLECULAR WEIGHT: 366,41 g/mole SYNONYMS: benzyl (2S,3S)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl1-oxopentan-2-ylcarbamate
1g
NH2
H N
O
ZAAX049.0001
N
ZAAX046 Z-Gly-Bt N-alpha-Benzyloxycarbonyl-glycine (1H-benzo[d][1,2,3]triazol-1-yl) ester CAS-NO: 173459-80-8 FORMULA: C16H14N4O3 MOLECULAR WEIGHT: 310,31 g/mole SYNONYMS: benzyl 1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxoethylcarbamate
Quantity Price
O
H N
O
(S)
O
N N
N
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany
Iris
Biotech
Available Biotinylating Reagent Superior to Biotin-NHS: Article No.
LS-X050 Biotin-Bt Biotin (1H-benzo[d][1,2,3]triazol-1-yl) ester FORMULA: C16H19N5O2S MOLECULAR WEIGHT: 345,52 g/mole SYNONYMS: (3aS,4S,6aR)-4-(5-(1H-benzo[d][1,2,3]triazol-1-yl)-5-oxopentyl) tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
H N
O
O
H
N
S
H
RL-1006 Biotin-OSu H N
O
O
H N
O
N O
S
H
LS-X051 Biotin-NHNH2
RL-2030
O
H
HN
N H
S
H
NH2
Biotin cadaverine
5-(Biotinamido)pentylamine FORMULA: C15H28N4O2S MOLECULAR WEIGHT: 328,47 g/mole
1g
€ 200,00
LS-X050.0005
5g
€ 600,00
RL-1006.0001
1g
€ 85,00
RL-1006.0005
5g
€ 300,00
RL-1006.0025
25 g € 1200,00
N
O
O
H
HN
Biotin hydrazide FORMULA: C10H18N4O2S MOLECULAR WEIGHT: 258,34 g/mole SYNONYMS: 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl) pentanehydrazide
LS-X050.0001 N
HN
N-Hydroxysuccinimidobiotin CAS-NO: 35013-72-0 FORMULA: C14H19N3O5S MOLECULAR WEIGHT: 341,39 g/mole SYNONYMS: D-Biotin N-hydroxysuccinimide ester, (+)-Biotin-NHS, NHS-biotin
Quantity Price
H N
O
O
H
HN
S
H
N H
LS-X051.0001
1g
€ 250,00
LS-X051.0005
5g
€ 900,00
RL-2030.0001
1g
€ 350,00
RL-2030.0005
5g
€ 1400,00
NH2
Custom Synthesis Service of Iris Biotech: ÎÎ Save your own manpower and time.
ÎÎ Labeling compounds for specific analytical techniques (19F-NMR, ESR, Chelators for Radionuklides)
ÎÎ Use our experience and expertise.
ÎÎ Sophisticated heterocycles
ÎÎ Save your money on trials we already made and lessons we already learned.
ÎÎ Monodisperse polyamines and PEG derivatives
ÎÎ Bring your project faster to success by using our technical support.
ÎÎ Azides and alkynes for click conjugation O O
N
O N
O
O O
N H
H N
N
N O
O
O
N O
O
O
O
O
O
O
O
O N3
OH
N
O
NH
N
OH OH
O
Send your inquiry to info@iris-biotech.de Internet: www.iris-biotech.de Email: info@iris-biotech.de
Tel.: +49-9231-9619-73 Fax: +49-9231-9619-99
Belgium Office: Tel.: +32 56 31 52 00 Fax: +32 56 31 15 00
Iris Biotech GmbH Waldershofer Str. 49-51 D-95615 Marktredwitz, Germany