PEGylation 2024

PEG ylation

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Empowering Peptide Innovation

With this guiding theme in mind, Iris Biotech’s mission is to support researchers by supplying

• innovative technologies, rare compounds, as well as a broad portfolio on standard consumables, available in flexible quantities from small scale to bulk quantities. To fulfill our dedication “Empowering Peptide Innovation”, we are attending various conferences, symposia, and exhibitions each year. This allows us to remain in direct contact with scientists all over the world, both from academia and industry, to exchange knowledge, and to gather new ideas to tackle your current challenges.

Guided by our dedication to provide competent service, as well as novel substances and latest technologies,

Iris Biotech is your trusted partner for the world of peptides, while having strong expertise in associated disciplines. Thus, our portfolio comprises reagents and tools for the synthesis and modification of peptides, e.g. amino acids, resins and solvents but also for related technologies such as Drug Delivery, Linkerology® and Life Sciences.

Acids Building Blocks Life Sciences Drug Delivery Reagents Resins Linkerology® Click Chemistry

Owed to the growing demand for tailor-made compounds, our portfolio is fine-tuned by our Custom Synthesis Service at Iris Biotech Laboratories. Our skilled scientists offer profound expertise in

• de novo route development,

• upscaling towards larger scale production,

• as well as synthesis optimization for increased efficiency.

Examples are the synthesis of rare chiral building blocks, unnatural amino acid derivatives, sophisticated orthogonal protecting groups, heterocycles, building blocks for nucleotides, PEGs and PEG-analogues as well as specific linkers for controlled drug delivery and release.

Amino

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Portfolio Overview

Peptide Synthesis and Modification

(Protected) Amino Acids

Standards such as Fmoc-D/L-AAA and Boc-D/L-AAA, Smoc amino acids for peptide synthesis in water, variety of protecting groups (e.g. Pbf, Trt, tBu, Bzl, Acm, Mob, SIT, Phacm, Allocam, Mmt), unusual amino acids, fluorinated derivatives, substituted prolines, arginine analogues

Building Blocks

Amino alcohols, amino aldehydes, diamines and hydrazines, (pseudoproline) dipeptides, polyamines and spermines, fatty acid derivatives

Reagents

Coupling reagents, solvents and scavengers, protecting groups

Resins

Preloaded resins (e.g. based on Trityl, TCP, TentaGel, Methoxybenzhydryl, Merrifield, PAM, Rink, Wang), scavenger resins, hydrazone resins

Linkerology® and Drug Delivery Life Sciences

Linkers for Solid Phase Peptide Synthesis

Cleavable Linkers

Val-Ala based, Val-Cit based, disulfide-based, Dde-helping hands

Photo-Activatable Linkers

Functionalized Linkers

Clickable linkers, trifunctional linkers, linkers with maleimide function, cross-linkers, selective N-term acylation and biotinylation

PROTACs

Ligands, linkers & modules

Fullerenes, Poly(2-oxazolines) & Dextrans

Poly-Amino Acids

Poly-Arg, Poly-Glu, Poly-Lys, Poly-Orn, Poly-Sar

PEGylation

Branched PEGylating reagents, (amino-)PEG-acids, PEG-amines & hydrazides & guanidines, reagents for Click-conjugation, Biotin-PEG-reagents, PEG-thiols, PEG-maleimides, other PEGylating reagents

Biotinylation Reagents

Carbohydrates

Galactose, Glucose, Maltose, Mannose, Xylose and others

Drug Metabolites

Peptides

Substrates & Inhibitors

E.g. protein kinase inhibitors, substrates for fusion (Halo/ Snap/Clip)-tagged proteins

Natural Products

Dyes and Fluorescent Labels

E.g. ICG, AMC, DAPI

Maillard & Amadori Reaction Products

Large portfolio of derivatives useful as standards for food, pharma and cosmetics industry

Vitamins

Custom Synthesis

Your project requires a compound not listed in our portfolio? Get in contact and inquire about our custom synthesis capabilities.

Our experienced scientists are excited to accept your synthetic challenge! In such cases, your request undergoes the following stages:

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Step-by-Step Analysis

• Customer’s demands

Process Evaluation

Detailed literature review

• Synthetic possibilities

Our Service Promise

Strategy Development

Protocol development

• Method development and validation

• Customized synthesis

Quality Consistency

Identity confirmation

• Purity verification

All our services are based on high standards, transparency & documentation, trust, honesty & confidentiality, as well as the required know-how.

High Standards

• Values: sustainability & responsibility

• State-of-the-art equipment & latest technologies

High quality standards

• Qualified suppliers & regular audits

Trust, Honesty & Confidentiality

Intergenerational business valuing partnerships

• Meeting the customer‘s expectations

Integrity towards our customers

Transparency & Documentation

• Talk to our specialists – customer care

• Certificates of analysis & impurity profiling

Analytical and process reports

Our Know-How

One-step reactions & complex multi-step synthesis

• Scalability from mg to kg quantities

Route scouting

. 1. Poly(ethylene glycol) –the Pioneer in Polymer Therapeutics

1.1. Background

PEGylated proteins were the first polymer therapeutic drugs reaching market approval around 1990. PEGs show a spectrum of unique physical and chemical properties which have been described in literature extensively. Here are summarized the most common ones:

PEG fragments can be attached to many different positions in a protein. Amino groups of any solvent accessible lysines as well as the N-termini are the most prominent candidates for conjugation together with thiol functions of cysteines. The C-terminus or carboxylic groups from aspartic acid and glutamic acid are also possible for conjugation, however, are less frequently used.

• PEG can serve as spacer or cross linker between two moieties.

• PEG provides high solubility and does not contain charged side chains.

PEG is FDA-approved for internal application, is non-toxic, lacks T-cell epitopes, and shows no signs of immunogenicity in most animal experiments.

• PEG derivatives are available from uniform molecules with short chain lengths (down to two ethylene oxide units only), to long disperse constructs, allowing regio-specific chemical conjugation with small molecules, proteins, peptides, and biopharmaceuticals through their broad variety of available terminal chemical groups.

Summary of chemical and physical properties of PEGs:

• Good solubility in BOTH hydrophilic AND hydrophobic solvents as water, toluene, methylene chloride, and many other organic solvents.

Insoluble in diethyl ether, hexane, ethylene glycol.

• Insoluble in water at elevated temperature.

• The solubility is influenced by formed derivatives.

• Highly mobile in water with high exclusion volume; large hydrodynamic radius.

• Complex formation with metal cations is possible. Can be used to precipitate proteins and nucleic acids.

Form two-phase systems with aqueous solutions of other polymers. Non-toxic and FDA-approved for use in drug products.

PEGylation of biopharmaceuticals or small molecules brings the following effects:

• Improves solubility of conjugated molecules.

Renders proteins non-immunogenic and tolerogenic.

Reduces the rate of renal clearance through the kidney and alters pharmacokinetics. Alters electroosmotic flow.

Increases cell permeability.

The increasing use of PEG and PEGylated products in pharmaceutical research and on the market provides new insights into the underlying mechanism of their properties. PEGs are e.g. not biodegradable in the human body, so it can lead to certain accumulation in cytoplasmic vacuoles, particularly at high doses and especially in kidneys:

Despite all sporadic drawbacks as mentioned above, PEG, nevertheless, is still the most widely applied polymer in drug delivery.

This brochure displays a portfolio of a thousand different PEG derivatives with a length ranging from only 2 ethylene glycol units (with a molecular weight around 100 g/mol) up to long chain PEGs of molecular weights beyond 20,000 g/mol. Further to this standard portfolio, we can produce also customized PEG variants according to your personal needs.

References:

→ Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice; M. R. Battista, A. Grigoletto, T. Tedeschini, A. Cellucci, F. Colaceci, R. Laufer, G. Pasut, A. Di Marco; PLOS ONE 2022; 17: e0265749. https://doi.org/10.1371/journal.pone.0265749

→ Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy; A. Dodd, A. A. Natfji, A. Evangelinos, A. Grigoletto, G. Pasut, F. Beards, L. Renshall, H. M. I. Osborn, F. Greco, L. K. Harris; Molecular pharmaceutics 2022; 19: 345-353. https://doi.org/10.1021/acs.molpharmaceut.1c00498

→ Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNAbased SARS-CoV-2 vaccines; J. Szebeni, G. Storm, J. Y. Ljubimova, M. Castells, E. J. Phillips, K. Turjeman, Y. Barenholz, D. J. A. Crommelin, M. A. Dobrovolskaia; Nature Nanotechnology 2022; 17: 337-346. https://doi.org/10.1038/s41565-022-01071-x

→ The role and impact of polyethylene glycol on anaphylactic reactions to COVID-19 nano-vaccines; P. Bigini, M. Gobbi, M. Bonati, A. Clavenna, M. Zucchetti, S. Garattini, G. Pasut; Nature Nanotechnology 2021; 16: 1169-1171. https://doi.org/10.1038/s41565-021-01001-3

→ Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines; S. M. Moghimi; Molecular Therapy 2021; 29: 898-900. https://doi.org/10.1016/j.ymthe.2021.01.030

→ Polyethylene glycol-based linkers as hydrophilicity reservoir for antibody-drug conjugates; T. Tedeschini, B. Campara, A. Grigoletto, M. Bellini, M. Salvalaio, Y. Matsuno, A. Suzuki, H. Yoshioka, G. Pasut; Journal of Controlled Release 2021; 337: 431-447. https://doi.org/10.1016/j.jconrel.2021.07.041

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Fig. 1: (Left) PEG immunoreactivity in kidney from rats given 100 mg/kg 10kPEG IV. There is variable but diffuse PEG staining in tubular epithelial cells throughout the renal cortex. PEG staining is not associated with epithelial cell vacuolation (Magnification 230x).

(Right) Cytoplasmic vacuoles (arrows) are associated with variable levels of PEG immunoreactivity in the kidney (300x) in rats given 100 mg/kg 40kPEG. The cortical tubule and choroid plexus had both darkly stained and clear vacuoles (pictures adapted from Rudman et al . 2013).

PEGylation

→ PEG hydration and conformation in aqueous solution: Hints to macromolecular crowding; S. Di Fonzo, B. Bellich, A. Gamini, N. Quadri, A. Cesàro; Polymer 2019; 175: 57-64. https://doi.org/10.1016/j.polymer.2019.05.004

→ A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers; D. Huesmann, A. Sevenich, B. Weber, M. Barz; Polymer 2015; 67: 240-248. https://doi.org/10.1016/j.polymer.2015.04.070

→ On the biodegradability of polyethylene glycol, polypeptoids and poly(2-oxazoline)s; J. Ulbricht, R. Jordan, R. Luxenhofer; Biomaterials 2014; 35: 4848-61. https://doi.org/10.1016/j.biomaterials.2014.02.029

→ Bioconjugate Techniques (Third Edition); G. T. Hermanson; G. T. Hermanson 2013: 1146. https://doi.org/10.1016/C2009-0-64240-9

→ Chapter 6 - Heterobifunctional Crosslinkers; G. T. Hermanson; Bioconjugate Techniques (Third Edition) G. T. Hermanson 2013: 299-339. https://doi.org/10.1016/B978-0-12-382239-0.00006-6

→ High molecular weight polyethylene glycol cellular distribution and PEG-associated cytoplasmic vacuolation is molecular weight dependent and does not require conjugation to proteins; D. G. Rudmann, J. T. Alston, J. C. Hanson, S. Heidel; Toxicol Pathol 2013; 41: 970-83. https://doi.org/10.1177/0192623312474726

→ Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications; S. S. Banerjee, N. Aher, R. Patil, J. Khandare; J Drug Deliv 2012; 103973 . https://doi.org/10.1155/2012/103973

→ Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics; M. Barz, R. Luxenhofer, R. Zentel, M. J. Vicent; Polymer Chemistry 2011; 2: 1900-1918. https://doi.org/10.1039/c0py00406e

→ Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives; K. Knop, R. Hoogenboom, D. Fischer, U. S. Schubert; Angew Chem Int Ed Engl 2010; 49: 6288-308. https://doi.org/10.1002/anie.200902672

→ Peptide and Protein PEGylation III: Advances in Chemistry and Clinical Applications; F. M. Veronese, J. M. Harris; Advanced Drug Delivery Reviews 2008; 60: 1-88.

→ PEGylation - The Magic Wand. Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters; T. Bruckdorfer; PharManufacturing 2007; 1: 34-41.

→ PEGylation, successful approach to drug delivery; F. M. Veronese, G. Pasut; Drug Discov Today 2005; 10: 1451-8.

https://doi.org/10.1016/S1359-6446(05)03575-0

→ PEGylated antibodies and antibody fragments for improved therapy: a review; A. P. Chapman; Adv Drug Deliv Rev 2002; 54: 531-45.

https://doi.org/10.1016/S0169-409X(02)00026-1

→ Chemistry for peptide and protein PEGylation; M. J. Roberts, M. D. Bentley, J. M. Harris; Adv Drug Deliv Rev 2002; 54: 459-76.

https://doi.org/10.1016/S0169-409X(02)00022-4

→ Peptide and protein PEGylation: a review of problems and solutions; F. M. Veronese; Biomaterials 2001; 22: 405-17.

https://doi.org/10.1016/S0142-9612(00)00193-9

→ Synthesis and characterization of poly(ethylene glycol) derivatives; J. M. Harris, E. C. Struck, M. G. Case, M. S. Paley, M. Yalpani, J. M. Van Alstine, D. E. Brooks; Journal of Polymer Science: Polymer Chemistry Edition 1984; 22: 341-352.

https://doi.org/10.1002/pol.1984.170220207

→ Functionalization of poly(ethylene glycol) and monomethoxy-poly(ethylene glycol); A. F. Bückmann, M. Morr, G. Johansson; Die Makromolekulare Chemie 1981; 182: 1379-1384. https://doi.org/10.1002/macp.1981.021820509

1.2. Principles of Polymer Therapeutics and Drug Delivery Systems

Modern drug development technologies such as combinatorial chemistry and automated high-throughput screening have led to the identification of numerous potential new active pharmaceutical ingredients (APls). However, many of those promising new molecules never reach market approval because they are not sufficiently soluble, cannot reach the desired target, are attacked by the immune system, are degraded by endogenous enzymes, or suffer from rapid renal clearance. To overcome these restrictions, first attempts with polymers were made already in the 1960s - either by attaching the therapeutic agent covalently to a polymer or by entrapping it non-covalently in a polymer nanoparticle.

The first polymer-drug conjugates that showed promising results contained poly(ethylene glycol) “PEG”, and until today, PEG is the most widely used gold standard for stealth polymers in the continuously emerging field of polymer-based drug delivery. The pharmacological effects of PEG and many other first generation polymer attachments are mainly of physical nature:

Solubilizing

PEG and many other polymers are very hygroscopic and hydrophilic and thus improve the plasma solubility of hydrophobic pharmaceuticals. By this, higher therapeutic concentrations in plasma and tissues are accessible.

Preventing Degradation and Reducing lmmunogenicity

Polymer chains are covering the surface of a pharmaceutical, thus efficiently shielding it against attacks by the immune system or degrading enzymes such as proteases. The polymeric shield has characteristics rather like a solvent than like a protein. This prevents uptake by the macrophage system. Recognition by the immune system (antibodies, proteases, and other degradation enzymes etc.) is significantly reduced. The drug stays intact and is not destroyed (degraded or metabolized) during its presence in the body and journey through the physiological system.

Preventing Excretion

Hygroscopic polymers are surrounded by a large solvating sphere of water molecules. The hydrodynamic radius of the polymer-drug conjugate can be increased to a size larger than the diameter of the kidney’s glomerular capillaries (6 to 12 nm). Retarded renal filtration prolongs plasma half-life of the biological drug by means of a purely biophysical size effect, without any receptor interactions that may influence pharmacodynamics or lead to side effects.

Fig. 2: PEGylation increases the hydrodynamic radius and aqueous solubility of proteins. Hence, the pharmacokinetic properties of a PEGylated drug in contrast to a non-PEGylated one are significantly different. The half-time in plasma is, therefore, significantly longer.

PEGylation

References:

→ Drug delivery systems for RNA therapeutics; K. Paunovska, D. Loughrey, J. E. Dahlman; Nat. Rev. Genetics 2022; 23: 265-280.

https://doi.org/10.1038/s41576-021-00439-4

→ Drug delivery systems in cancer therapy; B. Qorri, A. DeCarlo, M. Mellon, M. R. Szewczuk; Drug Delivery Devices and Therapeutic Systems 2021; 423-454 . https://doi.org/10.1016/b978-0-12-819838-4.00016-x

→ Chapter One - Molecular platforms for targeted drug delivery; K. Maso, A. Grigoletto, M. J. Vicent, G. Pasut; International Review of Cell and Molecular Biology L. Galluzzi 2019; 346: 1-50.

https://doi.org/10.1016/bs.ircmb.2019.03.001

→ Polymer-drug conjugate therapeutics: advances, insights and prospects; I. Ekladious, Y. L. Colson, M. W. Grinstaff; Nat. Rev. Drug discovery 2019; 18: 273-294. https://doi.org/10.1038/s41573-018-0005-0

→ Polymer Therapeutics: Design, Application, and Pharmacokinetics; B. A. Aderibigbe, H. E. Mukaya; Nano- and Microscale Drug Delivery Systems A. M. Grumezescu 2017: 33-48.

https://doi.org/10.1016/b978-0-323-52727-9.00003-0

→ Structure of a PEGylated protein reveals a highly porous double-helical assembly; G. Cattani, L. Vogeley, P. B. Crowley; Nat Chem 2015; 7: 823-8. https://doi.org/10.1038/nchem.2342

→ An Overview Of Polymer Therapeutics; G. Srinivasan, M. Vaishnavi; World Journal of Pharmaceutical Research 2014; 3: 1446-1467.

→ Polymer therapeutics: Top 10 selling pharmaceuticals — What next?; R. Duncan; Journal of Controlled Release 2014; 190: 371-380. https://doi.org/10.1016/j.jconrel.2014.05.001

→ Polymer therapeutics-prospects for 21st century: The end of the beginning; R. Duncan, M. J. Vicent; Advanced Drug Delivery Reviews 2013; 65: 60-70. https://doi.org/10.1016/j.addr.2012.08.012

→ Bioconjugate Techniques (Third Edition); G. T. Hermanson; G. T. Hermanson 2013: 1146.

https://doi.org/10.1016/C2009-0-64240-9

→ Polymer-Based Therapeutics; S. Liu, R. Maheshwari, K. L. Kiick; Macromolecules 2009; 42: 3-13. https://doi.org/10.1021/ma801782q

→ The dawning era of polymer therapeutics; R. Duncan; Nat. Rev. Drug discovery 2003; 2: 347-60. https://doi.org/10.1038/nrd1088

1.3. Chemical and Physical Properties of PEG Polymers

The most important parameter describing a polymer is the degree of polymerization “DP”. DP describes the number of monomeric units in a polymer molecule. If a polymer consists of only one single molecular weight species (a defined number n of repeating units), the polymer is called “homopolymer” or “uniform”. A common term previously used is “monodisperse”. Most polymers consist of a range of species with an average mass and a distribution of n around a mean value. These polymers are referred to as “polydisperse”, “disperse”, or “non-uniform”. If the polymer is polydisperse, its mass spectrum will show a range of different molecular weights as shown in a typical mass spectrum Fig. 4:

Fig. 3: Structure example of a PEG with DP = n.

Fig. 4: Mass spectrum of a PEG showing the typical signals with a difference of m/z = 44.

A measure of the distribution of molecular weights in a polymer is given by the Polydispersity or simply Dispersity Đ, which is defined as the ratio between the weight average molecular weight M°w and the number average molecular weight M°n :

The weight average M°w does not “count” species just by their number but considers the total weight of each species and is therefore a much more realistic indicator of the gross mechanical properties of a polymer. In case of a homopolymer with a defined chain length, M°w is equal to M°n , thus the dispersity Đ equals 1.00 and the compound is referred to as uniform. Whenever there is a distribution of molecular weights, the weight average M°w is always higher than the number average M°n , and consequently the dispersity Đ is greater than 1.00. The dispersity of polymers typically used in polymer therapeutics ranges between 1.01 and 1.20.

Generally, a rather low Đ value close to 1.00 is aspired as it is an indication for a well-controlled and mastered polymerization process. However, such a narrow weight distribution is not always of advantage in practice. For the formation of some nanostructures, it may be necessary to have a rather broad distribution of molecule sizes, resulting in a rather high dispersity Đ. For example, some polymers can form spheric nanoparticles when used at high dispersity but will form fibrils if used in a dispersity close to 1.00. In other applications, it may be necessary to have material with very low dispersity. In order to reach reproducible results, it is crucial to work with highly pure polymers of good batchtobatch reproducibility.

References:

→ Polymer-drug conjugate therapeutics: advances, insights and prospects; I. Ekladious, Y. L. Colson, M. W. Grinstaff; Nat. Rev. Drug discovery 2019; 18: 273-294. https://doi.org/10.1038/s41573-018-0005-0

→ Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications; A. Birke, J. Ling, M. Barz; Progress in Polymer Science 2018; 81: 163-208. https://doi.org/10.1016/j.progpolymsci.2018.01.002

→ Fundamentals of Polymer Science: An Introductory Text; P. C. Painter, M. M. Coleman; 1997: 22. https://doi.org/10.1201/9780203755211

1.4. Quality Parameters of PEG Polymers

For a small molecule, typically a rather limited set of analytical parameters (for example: purity by HPLC, identity by NMR or mass spectroscopy, and residual solvents content) is sufficient to describe the quality of each material batch.

For a polymer, a much more sophisticated analysis is necessary to describe the quality of the material comprehensively. Depending on the application’s needs and on authorities’ demand, the certificate of analysis for a therapeutic polymer may contain dozens of different analytical parameters.

The development of analytical methods and processes requires an extensive understanding of the polymer itself and about the expressiveness of the various analytical parameters.

For our therapeutic polymers, the analytical laboratory is staffed by highly-qualified personnel who use equipment specially focused, but not limited, to the quality control of polymers. All instruments are qualified, and the validated analysis conforms to international and European standards.

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PEGylation

1.5. Modes of Polymer Application

During the last decades, PEG and several other polymers have entered the field of drug delivery: natural and nonnatural ones, biodegradable and non-degradable ones, such as: proteins, poly(amino acids), peptides, peptoids, polysaccharides, modified cellulose derivatives, polyesters, polyamides, polyanhydrides, polyphosphonates, polyacrylates, and many more. Independent of their chemical nature, polymer therapeutics can be classified by their mode of application:

Polymeric Drugs

The polymer itself is the active pharmaceutical ingredient. One market approved example is Copaxone®, a random copolymer of Alanine, Glutamate, Lysine, and Tyrosine for the treatment of multiple sclerosis.

Polymer-Drug Conjugates

Here, a polymer backbone carries one or several active moieties, as for example in Opaxio®, a poly(glutamic acid)-Paclitaxel conjugate for cancer treatment.

Polymer-Protein Conjugates

One or several polymer chains are attached to a protein, peptide, or antibody, as for example in Pegasys®, a PEGylated Interferon alpha 2a for the treatment of Hepatitis C.

Polymer-Based Hydrogels

Some polymers can be used to form hydrogels of defined pore size, water content, life-time and many more properties. Such hydrogels can be used to cage active ingredients, keep them perfectly hydrated, regulate their skin or tissue permeation, dose their release, and thus optimize their function. Often, such hydrogels are used in cosmetic applications.

Polymer-Based Nanoparticles

These nanoparticles are typically formed by a mixture of different lipid and polymer types and can form - among others - micelles (consisting of a monolayer), liposomes (consisting of a bilayer), or lipid nanoparticles “LNPs” (composed of multiple lipid layers as well as microdomains of lipid and nucleic acid). Examples for such nanoparticles are the latest mRNA-based SARS-CoV2 vaccines from Moderna, BioNTech/Pfizer or CureVac.

These different application modes already point out that polymer therapeutics offer far more possibilities than the simple shielding and enlarging effects previously mentioned.

Concentration Effect

A large polyvalent polymeric carrier can enable the attachment of several active moieties on one macromolecule. If, for example, the pharmaceutical role of the active ingredient is to bind and block a surface receptor, the presence of several binding ligands will significantly increase the binding energy and thus lead to a more efficient receptor binding. As non-covalent receptor binding is a dynamic equilibrium of association and dissociation, a released single small molecule can easily be departed by the bloodstream and thus be prevented from re-binding. However, if it is part of a polymer which binds to the cell surface by several other of its binding moieties, it will not diffuse away, but will re-bind quickly to any free receptor on the surface.

Targeting Effect

A polymer carrier can be equipped both with a targeting moiety and with active molecules. For example, an RGD peptide can guide the polymer to cancer cells. After internalization, several bound cytotoxic molecules such as Paclitaxel can be released to kill the abnormal cell.

Shuttle Effect

An intelligent design of the drug delivery system can help transporting a payload to destinations where it could not go without the polymer’s help. There are systems that help crossing the skin barrier, some poly(amino acids) can help small molecules to cross cell membranes, LNPs as nonviral vectors can even transport DNA and RNA into living cells, and other polymers help crossing the blood-brain-barrier. back to content arrow-up

Fig. 5: Schematic representation of nanoparticles: micelle, liposome and lipid nanoparticle (from left to right).

PEGylation

Combination Effect

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Some cells develop resistance to a pharmaceutical treatment. If this happens, the treatment must be changed to a new strategy and cells may subsequently also develop resistance to the altered therapy. However, in polymer therapeutics, the two different active ingredients can be attached to one polymer. The simultaneous delivery of two different active cargos strongly suppresses the formation of resistances, because cells would have to develop both resistances at the same time, which is almost impossible. .

Interested in poly(amino acids) for polymeric support of small molecule drug formulation, lipidated nanoparticels, e.g. for encapsulation of mRNA, and other biodegradable polymers like poly(2-oxazolines) and polysarcosines?

Please investigate our brochure “Polymer Therapeutics“.

References:

→ Drug delivery systems for RNA therapeutics; K. Paunovska, D. Loughrey, J. E. Dahlman; Nat. Rev. Genetics 2022; 23: 265-280.

https://doi.org/10.1038/s41576-021-00439-4

→ Polymer-based non-viral vectors for gene therapy in the skin; L. Tortajada, C. Felip-León, M. J. Vicent; Polymer Chemistry 2022; 13: 718-735. https://doi.org/10.1039/D1PY01485D

→ Polyamide/Poly(Amino Acid) Polymers for Drug Delivery; S. H. S. Boddu, P. Bhagav, P. K. Karla, S. Jacob, M. D. Adatiya, T. M. Dhameliya, K. M. Ranch, A. K. Tiwari; Journal of Functional Biomaterials 2021; 12: 58. https://doi.org/10.3390/jfb12040058

→ Polypeptides as building blocks for image-guided nanotherapies; I. Conejos-Sánchez, S. Đorđević, M. Medel, M. J. Vicent; Current Opinion in Biomedical Engineering 2021; 20: 100323. https://doi.org/10.1016/j.cobme.2021.100323

→ Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery; T. Holmstrom, M. Galsgaard Malle, S. Wu, K. J. Jensen, N. S. Hatzakis, C. M. Pedersen; Chemistry 2021. https://doi.org/10.1002/chem.202005332

→ From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases; E. H. Pilkington, E. J. A. Suys, N. L. Trevaskis, A. K. Wheatley, D. Zukancic, A. Algarni, H. Al-Wassiti, T. P. Davis, C. W. Pouton, S. J. Kent, N. P. Truong; Acta Biomater 2021; 131. https://doi.org/10.1016/j.actbio.2021.06.023

→ Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2; T. A. Tummino, V. V. Rezelj, B. Fischer, A. Fischer, M. J. O’Meara, B. Monel, T. Vallet, K. M. White, Z. Zhang, A. Alon, H. Schadt, H. R. O’Donnell, J. Lyu, R. Rosales, B. L. McGovern, R. Rathnasinghe, S. Jangra, M. Schotsaert, J.-R. Galarneau, N. J. Krogan, L. Urban, K. M. Shokat, A. C. Kruse, A. García-Sastre, O. Schwartz, F. Moretti, M. Vignuzzi, F. Pognan, B. K. Shoichet; Science 2021; 373: 541-547. https://doi.org/10.1126/science.abi4708

→ The evolution of commercial drug delivery technologies; A. M. Vargason, A. C. Anselmo, S. Mitragotri; Nature Biomedical Engineering 2021; 5: 951-967. https://doi.org/10.1038/s41551-021-00698-w

→ A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy; W. Mu, Q. Chu, Y. Liu, N. Zhang; Nano-Micro Letters 2020; 12. https://doi.org/10.1007/s40820-020-00482-6

→ Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery; S. S. Nogueira, A. Schlegel, K. Maxeiner, B. Weber, M. Barz, M. A. Schroer, C. E. Blanchet, D. I. Svergun, S. Ramishetti, D. Peer, P. Langguth, U. Sahin, H. Haas; ACS Applied Nano Materials 2020; 3: 10634-10645. https://doi.org/10.1021/acsanm.0c01834

→ Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment; S. P. Atkinson, Z. Andreu, M. J. Vicent; J Pers Med 2018; 8: 6. https://doi.org/10.3390/jpm8010006

→ Polymer Therapeutics: Design, Application, and Pharmacokinetics; B. A. Aderibigbe, H. E. Mukaya; Nano- and Microscale Drug Delivery Systems A. M. Grumezescu 2017: 33-48. https://doi.org/10.1016/b978-0-323-52727-9.00003-0

→ A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules; S. M. Barros, S. K. Whitaker, P. Sukthankar, L. A. Avila, S. Gudlur, M. Warner, E. I. Beltrao, J. M. Tomich; Archives of biochemistry and biophysics 2016; 596: 22-42.

https://doi.org/10.1016/j.abb.2016.02.027

→ Peptide-Based Polymer Therapeutics; A. Duro-Castano, I. Conejos-Sánchez, M. Vicent; Polymers 2014; 6: 515-551. https://doi.org/10.3390/polym6020515

→ Factors influencing in vivo disposition of polymeric micelles on multiple administrations; E. Hara, M. Ueda, A. Makino, I. Hara, E. Ozeki, S. Kimura; ACS Med Chem Lett 2014; 5: 873-7. https://doi.org/10.1021/ml500112u

→ An Overview Of Polymer Therapeutics; G. Srinivasan, M. Vaishnavi; World Journal of Pharmaceutical Research 2014; 3: 1446-1467.

→ Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities; R. Duncan, M. J. Vicent; Adv Drug Deliv Rev 2010; 62: 272-82. https://doi.org/10.1016/j.addr.2009.12.005

PEGylation

2. Amino-PEG-Acids, -Esters, & -Ethers

.

2.1. Unprotected Amino-PEG-Acids & -Esters

PEG1365 H2 N-PEG(2)-CO-Ot Bu

3-(2-(2-Aminoethoxy)ethoxy)propanoic acid t-butyl ester

CAS-No. 756525-95-8

Formula C11H23 NO4 Mol. weight 233,3 g/mol

PEG2420 H-O2Oc-OH

[2-(2-aminoethoxy)ethoxy]acetic acid

CAS-No. 134978-97-5

Formula C 6 H13 NO4 Mol. weight 163,17 g/mol

PEG7940

H-O2Oc-OH*HCl

8-amino-3,6-dioxaoctanoic acid hydrochloride

CAS-No. 134979-01-4

Formula C 6 H13 NO4*HCl Mol. weight 163,17*36,45 g/mol

PEG2430 H-O2Oc-Ot Bu*HCI

[2-(2-aminoethoxy)ethoxy]acetic acid tert-butyl ester*HCl

CAS-No. 2098500-69-5

Formula C10 H21NO4*HCI

Mol. weight 219,28*36,45 g/mol

PEG1370 H2 N-dPEG(4)-COOH

15-Amino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 663921-15-1

Formula C11H23 NO 6

Mol. weight 265,3 g/mol

PEG1375 H2 N-dPEG(4)-CO-Ot Bu

15-Amino-4,7,10,13-tetraoxa-pentadecanoic acid t-butyl ester

CAS-No. 581065-95-4

Formula C15H31NO 6

Mol. weight 321,41 g/mol

PEG1221

H-O2Oc-O2Oc-OH

17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan1-oic acid

CAS-No. 1143516-05-5

Formula C12H24N2O 7

Mol. weight 308,33 g/mol

PEG1300

H2 N-PEG(6)-COOH

1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 905954-28-1

Formula C15H31NO 8

Mol. weight 353,41 g/mol

PEG1305

H2 N-dPEG(6)-CO-Ot Bu

1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid t-butyl ester

CAS-No. 1286281-32-0

Formula C19 H39 NO 8

Mol. weight 409,51 g/mol

PEG2770 H-O2Oc-O2Oc-O2Oc-OH

26-amino-10,19-dioxo-3,6,12,15,21,24-hexaoxa-9,18-diazahexacosan-1-oic acid

CAS-No. 2773558-06-6

Formula C18 H35N3 O 10

Mol. weight 453,48 g/mol

PEG8060 H-O2Oc-O2Oc-O2Oc-O2Oc-OH

8-amino-3,6-dioxaoctanoic acid tetramer

CAS-No. 2773558-66-8

Formula C 24H46 N4O 13

Mol. weight 598,64 g/mol

PEG1380 H2 N-PEG(8)-COOH

1-Amino-3,6,9,12,15,18,21,24-octaoxaheptaeicosane-27-oic acid

CAS-No. 756526-04-2

Formula C19 H39 NO

Mol. weight 441,51 g/mol

PEG1385 H2 N-PEG(8)-CO-Ot Bu

1-Amino-3,6,9,12,15,18,21,24-octaoxaheptaeicosane-27-oic acid t-butyl ester

CAS-No. 756526-06-4

Formula C 23 H47NO

Mol. weight 497,62 g/mol

PEG1345 H2 N-PEG(12)-COOH

1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid

CAS-No. 1415408-69-3

Formula C 27H 55NO 14 Mol. weight 617,72 g/mol

PEG1350 H2 N-dPEG(12)-CO-Ot Bu

1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid t-butyl ester

CAS-No. 872340-65-3

Formula C 31H 63 NO 14 Mol. weight 673,83 g/mol

PEG1355 H2 N-PEG(24)-COOH

alpha-Amino-24(ethylene glycol)-omega-propionic acid

CAS-No. 196936-04-6

Formula C 51H103 NO

PEG1360 H2 N-dPEG(24)-CO-Ot Bu

alpha-Amino-24(ethylene glycol)-omega-propionic acid t-butyl ester

CAS-No. 872340-65-3

Formula C 55H111NO 26 Mol. weight 1202,49 g/mol

PEG3340 H2

N-dPEG™(36)-COOH

alpha-Amino-omega-propionic acid-36(ethylen glycol)

CAS-No. 196936-04-6

Formula C 75H151NO 38

Mol. weight 1674,99 g/mol

PEG3710

H2 N-dPEG™(36)-CO-Ot Bu

alpha-Amino-omega-(t-butyl propionate) 36(ethylene glycol)

CAS-No. 872340-65-3

Formula C 79 H159 NO 38 Mol. weight 1731,09 g/mol

PEG1096

H2 N-PEG-COOH*HCl (3 kDa)

alpha-Amino-omega-carboxy poly(ethylene glycol)

PEG1097

H2 N-PEG-COOH*HCl (5 kDa)

alpha-Amino-omega-carboxy poly(ethylene glycol)

PEG1095

H2 N-PEG-COOH*HCl (10 kDa)

alpha-Amino-omega-carboxy poly(ethylene glycol)

10000 Da

PEG7390 H2 N-PEG(12)-[PEG(24)-CO-Ot Bu] 3

Amino-PEG(12)-[PEG(24)-propionic acid t-butyl ester] 3

Formula C 205H403 N 5 O 97

Mol.

PEG7310 H2 N-PEG(4)-Glu-PEG(24)-OMe N-alpha-(amino-tetra(ethylene glycol))-L-glutamic acid alpha-(mPEG(24)) ester

PEG7330 H2 N-[PEG(4)-Glu] 3 -PEG(24)-OMe tris[amino-tetra(ethylene glycol))-L-glutamyl]-(mPEG(24)) ester

PEG7320 H2 N-PEG(4)-Glu-PEG(4)-Glu-PEG(24)-OMe bis[amino-tetra(ethylene glycol))-L-glutamyl]-(mPEG(24)) ester

PEG6880 DOTA-PEG(4)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-tetra(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

2.2. Aloc-Amino-PEG-Acids

AAA1905 Aloc-O2Oc-OH*DCHA

8-(Allyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylamine

CAS-No. 560088-74-6

Formula C10 H17NO 6*C12H23 N

Mol. weight 247,11*181,32 g/mol

2.3. Boc-Amino-PEG-Acids

BAA5240 Boc-O1Pen-OH*DCHA

5-(t-Butyloxycarbonyl-amino)-3-oxapentanoic acid

CAS-No. 142929-49-5 net

Formula C9 H17NO 5*C12H23 N Mol. weight 219,24*181,32 g/mol

BAA6070

Boc,Pbf-amidino-O1Pen-OH

5-[N-t-Butyloxycarbonyl-N‘-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]amidino-3-oxapentanoic acid

CAS-No. 1263049-05-3

Formula C 23 H35N3 O 8 S Mol. weight 513,61 g/mol

PEG8080 Boc-O2Oc-OH

(2-(2-(t-Butyloxycarbonylamino)ethoxy)ethoxy)acetic acid

CAS-No. 108466-89-3

Formula C11H21NO 6

Mol. weight 263,29 g/mol

BAA1466 Boc-O2Oc-OH*DCHA

8-(t-Butyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylammonium salt

CAS-No. 560088-79-1

Formula C11H21NO 6*C12H23 N

Mol. weight 263,29*181,32 g/mol

BAA6080 Boc,Pbf-amidino-O2Oc-OH

8-[N-t-Butyloxycarbonyl-N‘-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]amidino-3,6-dioxaoctanoic acid

CAS-No. 1263049-06-4

Formula C 25H39 N3 O 9 S

Mol. weight 557,66 g/mol

PEG4930 Boc-NH-PEG(3)-COOH

1-(t-Butyloxycarbonyl)amino-3,6,9-trioxadodecan-12oic acid

CAS-No. 1347750-75-7

Formula C14H27NO 7

Mol. weight 321,37 g/mol

PEG1920 Boc-NH-PEG(4)-COOH

15-t-Butyloxycarbonylamino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 756525-91-4

Formula C16 H31NO 8

Mol. weight 365,42 g/mol

BAA1485 Boc-O2Oc-O2Oc-OH

17-(t-Butyloxycarbonyl-amino)-9-aza-3,6,12,15-tetraoxa-10-on-heptadecanoic acid

CAS-No. 1069067-08-8

Formula C17H32N2O 9

Mol. weight 408,45 g/mol

BAA4910 Boc-O2Oc-O2Oc-O2Oc-OH

2,2-dimethyl-6,13,22-trioxo-3,8,11,17,20,26,29-heptaoxa-5,14,23-triazahentriacontan-31-oic acid

Formula C 23 H43 N3 O 12 Mol. weight 553,61 g/mol

PEG4920 Boc-NH-PEG(5)-COOH

1-(t-Butyloxycarbonyl)amino-3,6,9,12,15-pentaoxaoctadecan-18-oic acid

CAS-No. 1347750-78-0

Formula C18 H35NO 9 Mol. weight 409,47 g/mol

PEG4910 Boc-NH-PEG(6)-COOH

1-(t-Butyloxycarbonyl)amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 882847-13-4

Formula C 20 H39 NO 10 Mol. weight 453,52 g/mol

PEG2410

Boc-NH-PEG(8)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy octa(ethylene glycol)

CAS-No.

NO

PEG1071

Boc-NH-PEG(8)-COOH

alpha-t-Butyloxycarbonylamino-omega-diglycolic acid octa(ethylene glycol)

PEG1070

Boc-NH-PEG(12)-COOH

alpha-t-Butyloxycarbonylamino-omega-[(aminocarboxymethoxy)acetic acid] dodecae(ethylene glycol)

PEG2415

Boc-NH-PEG(12)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy dodeca(ethylene glycol)

PEG4480

Boc-NH-dPEG™(24)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy 24(ethylene

PEG1995 Boc-NH-PEG(27)-COOH

alpha-t-Butyloxycarbonylamino-27(ethylene glycol)-omega-propionic acid

PEG4490

Boc-NH-dPEG™(36)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy 36(ethylene glycol)

CAS-No. 187848-68-6

Formula C 80 H159 NO40

Mol. weight 1775,1 g/mol

PEG1073

Boc-NH-PEG-COOH (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy poly(ethylene glycol)

weight 3000 Da

PEG1074

Boc-NH-PEG-COOH (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy po-

PEG1072

Boc-NH-PEG-COOH (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy po-

CAS-No. 1626344-87-3

Mol. weight 10000 Da

PEG1111

Boc-NH-PEG-NHS (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1112

Boc-NH-PEG-NHS (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1110

Boc-NH-PEG-NHS

(10 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 10000 Da

2.4. Dde-Amino-PEG-Acids

DAA1016 Dde-O2Oc-OH

8-[(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl-amino]-3,6-dioxaoctanoic acid, {2-[2-(Dde-amino) ethoxy]ethoxy}acetic acid

CAS-No. 1263045-93-7

Formula C16 H25NO 6

Mol. weight 327,37 g/mol

2.5. Dnp-Amino-PEG-Acids

PEG2145

Dnp-NH-PEG(4)-COOH

1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid

CAS-No. 858126-76-8

Formula C17H25N3 O 10

Mol. weight 431,39 g/mol

PEG2150

Dnp-NH-PEG(4)-NHS

1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester

CAS-No. 858126-78-0

Formula C 21H28 N4O 12

Mol. weight 528,47 g/mol

Product details

Product details

Product details

PEG2285

Dnp-NH-PEG(12)-COOH

alpha-(2,4-Dinitrophenyl)amino-omega-carboxy dodeca(ethylene glycol)

CAS-No. 1334178-00-5

Formula

PEG2290

Dnp-NH-PEG(12)-NHS

alpha-(2,4-Dinitrophenyl)amino-omega-succinimidyl ester dodeca(ethylene glycol)

CAS-No. 1334178-01-6

Formula C 34H 60 N4O

2.6. DOTA-Amino-PEG-Acids

PEG6880

DOTA-PEG(4)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-tetra(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

PEG6890

DOTA-PEG(12)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-dodeca(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

PEG6860

DOTA(t Bu3)-PEG(12)-TFP

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-dodeca(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate)

Product details

PEG6900

DOTA-PEG(24)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-24(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

weight 1680,81*228,05 g/mol

PEG6870

DOTA(t Bu3)-PEG(24)-TFP

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-24(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate)

Formula C 85H153 F4N 5 O 33

2.7. Fmoc-Amino-PEG-Acids

FAA1565

Fmoc-O1Pen-OH

5-(9-Fluorenylmethyloxycarbonyl-amino)-3-oxapentanoic acid

CAS-No. 260367-12-2

Formula C19 H19 NO 5

Product details

FAA1435

Fmoc-O2Oc-OH

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

CAS-No. 166108-71-0

Formula C 21H23 NO 6 Mol. weight 385,42 g/mol

FAA6020

Fmoc-O2Oc-PFP

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid pentafluorophenyl ester

CAS-No. 1263044-39-8

Formula C 27H22F5NO 6 Mol. weight 551,5 g/mol

PEG1810 Fmoc-AEEP

3-(2-(2-(9-Fluorenylmethyloxycarbonyl)aminoethoxy) ethoxy)propanoic acid

CAS-No. 872679-70-4

Formula C 22H25NO 6

Mol. weight 399,44 g/mol

PEG4970 Fmoc-Ebes

N-[8-(9-Fluorenylmethyloxycarbonyl)amino-3,6-dioxaoctyl]succinamic acid

CAS-No. 613245-91-3

Formula C 25H30 N2O 7

Mol. weight 470,51 g/mol

PEG5180 Fmoc-DOOA-DIG-OH

2-(2-(2-(2-((9-Fluorenylmethyloxycarbonyl)amino) ethoxy)ethoxy)ethylamino)-diglycolic acid

CAS-No. 669073-64-7

Formula C 25H30 N2O 8

Mol. weight 486,51 g/mol

PEG4370 Fmoc-NH-PEG(3)-COOH

12-(9-Fluorenylmethyloxycarbonylamino)-4,7,10-trioxa-dodecanoic acid

CAS-No. 867062-95-1

Formula C 24H29 NO 7

Mol. weight 443,49 g/mol

PEG8200 Fmoc-NMe-PEG(3)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9-trioxydodecan-12-oic acid

CAS-No. 1807518-77-9

Formula C 25H31NO 7

Mol. weight 457,52 g/mol

RL-4400 Fmoc-NH-PEG(3)-NH-Suc-OH

1-(9H-fluoren-9-yl)-3,17-dioxo-2,7,10,13-tetraoxa-4,16diazaicosan-20-oic acid

CAS-No. 1653992-32-5

Formula C 27H34N2O 8

Mol. weight 514,57 g/mol

RL-4410

Fmoc-NH-PEG(3)-DIG-OH

1-(9H-fluoren-9-yl)-3,17-dioxo-2,7,10,13,19-pentaoxa-4,16-diazahenicosan-21-oic acid

CAS-No. 489427-26-1

Formula C 27H34N2O 9

Mol. weight 530,57 g/mol

FAA1568

Fmoc-TTDS-OH

[N1-(9-Fluorenylmethoxycarbonyl)-1,13-diamino-4,7,10-trioxatridecan-succinamic acid

CAS-No. 172089-14-4

Formula C 29 H38 N2O 8

Mol. weight 542,63 g/mol

PEG1820

Fmoc-NH-PEG(4)-COOH

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 557756-85-1

Formula C 26 H33 NO 8

Mol. weight 487,54 g/mol

PEG8210

Fmoc-NMe-PEG(4)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12-tetraoxypentadecan-15-oic acid

CAS-No. 2170240-98-7

Formula C 27H35NO 8

Mol. weight 501,58 g/mol

PEG4410 Fmoc-NH-dPEG™(4)-NHS

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 1314378-14-7

Formula C 30 H36 N2O 10

Mol. weight 584,24 g/mol

PEG7810 Fmoc-NH-dPEG™(4)-TFP

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoic acid (2,3,5,6-tetrafluorophenyl) ester

Formula C 32H33 F4NO 8

Mol. weight 635,6

FAA1787 Fmoc-O2Oc-O2Oc-OH

17-(9-Fluorenylmethyloxycarbonyl-amino)-9-aza-3,6,12,15-tetraoxa-10-on-heptadecanoic acid

CAS-No. 560088-89-3

Formula

PEG6825 Fmoc-O2Oc-O2Oc-O2Oc-OH

Fmoc-8-amino-3,6-dioxaoctanoic acid trimer

CAS-No. 2379531-43-6

Formula C 33 H45N3 O 12 Mol. weight 675,73

FAA6790 Fmoc-O2Oc-O2Oc-PFP

17-(9-Fluorenylmethyloxycarbonyl-amino)-9-aza-3,6,12,15-tetraoxa-10-on-heptadecanoic acid pentafluorophenyl ester

Formula C 33 H33 F5N2O 9

Mol. weight 696,61 g/mol

PEG4380 Fmoc-NH-PEG(5)-COOH

18-(9-Fluorenylmethyloxycarbonylamino)-4,7,10, 13-tetraoxa-octadecanoic acid

CAS-No. 882847-32-7

Formula C 28 H37NO 9

Mol. weight 531,59 g/mol

PEG8220 Fmoc-NMe-PEG(5)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15-pentaoxyoctadecan-18-oic acid

Formula C 29 H39 NO 9

Mol. weight 545,63 g/mol

PEG1825 Fmoc-NH-PEG(6)-COOH

1-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 882847-34-9

Formula C 30 H41NO 10

Mol. weight 575,65 g/mol

PEG8230

Fmoc-NMe-PEG(6)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino3,6,9,12,15,18-henicosan-21-oic acid

Formula C

NO

PEG1830

Fmoc-NH-PEG(8)-COOH

1-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid

CAS-No. 756526-02-0

Formula C 34H49 NO 12

weight 663,75 g/mol

PEG4420

Fmoc-NH-dPEG™(8)-NHS

alpha-(Fmoc-amino)-omega-(succinimidyl propionate) octa(ethylene glycol)

CAS-No. 1334170-03-4

Formula C 38 H 52N2O 14

PEG7820 Fmoc-NH-dPEG™(8)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) octa(ethylene glycol)

PEG1080

Fmoc-NH-PEG(12)-COOH

1-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15,18,2 1,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid

CAS-No. 1952360-91-6

Formula C 42H 65NO

PEG4430 Fmoc-NH-dPEG™(12)-NHS

alpha-(Fmoc-amino)-omega-(succinimidyl propionate) dodeca(ethylene glycol)

CAS-No. 488085-18-3

Formula

PEG7830 Fmoc-NH-dPEG™(12)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) dodeca(ethylene glycol)

PEG1210

Fmoc-NH-PEG(27)-COOH

alpha-(9-Fluorenylmethyloxycarbonyl)amino-27(ethylene glycol)-omega-propionic acid

CAS-No. 2101605-02-9

Formula C 74H129 NO 32

PEG1815

Fmoc-NH-dPEG(24)-COOH

alpha-Fmoc-amino-24(ethylene glycol)-omega-carboxylic acid

CAS-No. 2170484-59-8

Formula C 66 H113 NO

PEG7840 Fmoc-NH-dPEG™(24)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) 24(ethylene glycol)

PEG4400 Fmoc-NH-dPEG™(36)-COOH

alpha-Fmoc-amino-36(ethylene glycol)-omega-carboxylic acid

CAS-No. 850312-72-0

Formula C90 H161NO40

PEG7850 Fmoc-NH-dPEG™(36)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) 36(ethylene glycol)

PEG1108

Fmoc-NH-PEG-COOH (3 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy poly(ethylene glycol)

Mol. weight 3000 Da

PEG1109

Fmoc-NH-PEG-COOH (5 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1107

Fmoc-NH-PEG-COOH (10 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy poly(ethylene glycol)

weight 10000 Da

PEG1117

Fmoc-NH-PEG-NHS (3 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1118

Fmoc-NH-PEG-NHS (5 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1116

Fmoc-NH-PEG-NHS (10 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEGylation

2.8. Mtt-Amino-PEG-Acids

PEG4650 Mtt-O2Oc-OH*DEA

N-(4-Methyltrity)-8-amino-3,6-dioxaoctanoic acid diethylamine

CAS-No. 2098500-66-2

Formula C 26 H29 NO4*C 4H11N

Mol. weight 419,51*73,14 g/mol

PEG2161 Mtt-NH-PEG(4)-COOH*TEA

1-( p-Methytritylamino)-3,6,9,12-tetraoxapentadecanoic acid triethylamionium salt

CAS-No. 1310680-33-1 (net)

Formula C 31H39 NO 6*C 6 H15N

Mol. weight C31H39NO6*C6H15N g/mol

2.9. Z-Amino-PEG-Acids

PEG4710 Z-O1Pen-OH

5-(Benzyloxycarbonyl-amino)-3-oxa-pentanoic acid

CAS-No. 1260092-43-0

Formula C12H 5NO 5

Mol. weight 253,25 g/mol

Product details

Product details

ZAA1186 Z-O2Oc-OH*DCHA

8-(Benzyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylamine

CAS-No. 560088-84-8

Formula C14H19 NO 6*C12H23 N

Mol. weight 297,31*181,32 g/mol

PEG1495 Z-NH-dPEG(4)-COOH

15-Benzyloxycarbonylamino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 756526-00-8

Formula C19 H29 NO 8

Mol. weight 399,44 g/mol

PEG1795

Z-NH-dPEG(6)-COOH

1-Benzyloxycarbonylamino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 1334177-80-8

Formula C 23 H37NO 10 Mol. weight 487,54 g/mol

PEG1800

Z-NH-dPEG(8)-COOH

1-Benzyloxycarbonylamino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid

CAS-No. 1334177-87-5

Formula C 27H45NO 12 Mol. weight 575,65 g/mol

PEG1785

Z-NH-dPEG(12)-COOH

1-Benzyloxycarbonylamino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid

CAS-No. 1334177-88-6

Formula C 35H 61NO 16 Mol. weight 751,86 g/mol

PEG1790

Z-NH-dPEG(24)-COOH

alpha-Benzyloxycarbonylamino-24(ethylene glycol)-omega-propionic acid

CAS-No. 1334177-88-6

Formula C 59 H109 NO 28 Mol. weight 1280,52 g/mol

PEG4590

Z-NH-dPEG™(36)-COOH

alpha-Benzyloxycarbonylamino-amino-36(ethylene glycol)-omega-carboxylic acid

CAS-No. 1334177-88-6

Formula C 83 H157NO40 Mol. weight 1809,12 g/mol

PEGylation

3. PEG-Acids & -Esters

.

3.1. Unprotected Hydroxy-PEG-Acids & -Esters

PEG1535

HO-dPEG(4)-CO-Ot Bu

15-Hydroxy-4,7,10,13-tetraoxa-pentadecanoic acid

t-butyl ester

CAS-No. 518044-32-1

Formula C15H30 O 7 Mol.

PEG7220

HO-PEG(4)-TFP

Hydroxy-tetra(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenyl ester

Formula C17H22F4O 7 Mol.

PEG2355

HO-PEG(6)-CO-Ot Bu

alpha-Hydroxy-omega-carboxy t-butyl ester hexa(ethylene glycol)

CAS-No. 361189-64-2

Formula C19 H38 O 9 Mol. weight 410,5 g/mol

PEG1540

HO-dPEG(8)-CO-Ot Bu

t-Butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

CAS-No. 1334177-84-2

Formula C 23 H46 O 11 Mol.

PEG1090

HO-PEG(12)-CO-Ot Bu

alpha-Hydroxy-omega-t-butyl propionat dodecae(ethylene glycol)

CAS-No. 1186025-29-5

Formula C 31H 62O 15 Mol.

PEG2360

HO-PEG(12)-COO-t Bu

alpha-Hydroxy-omega-carboxy t-butyl ester dodeca(ethylene glycol)

CAS-No. 1186025-29-5

Formula C 31H 62O 15

Mol. weight 674,81 g/mol

PEG7230

HO-PEG(12)-TFP

Hydroxy-dodeca(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenyl ester

Formula C 33 H 54F4O 15 Mol. weight 766,77 g/mol

PEG2365

HO-PEG(24)-CO-t Bu

alpha-Hydroxy-omega-carboxy t-butyl ester 24(ethylene glycol)

CAS-No. 1186025-29-5

Formula C 55H110 O 27 Mol. weight 1203,45 g/mol

PEG7240

HO-PEG(24)-TFP

Hydroxy-24(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenyl ester

Formula C 57H102F4O 27

PEG1093

HO-PEG-COOH (3 kDa)

alpha-Hydroxy-omega-carboxy poly(ethylene glycol)

PEG1094 HO-PEG-COOH (5 kDa)

alpha-Hydroxy-omega-carboxy poly(ethylene glycol)

PEG1092 HO-PEG-COOH (10 kDa)

alpha-Hydroxy-omega-carboxy poly(ethylene glycol)

Mol. weight 10000 Da

3.2. PEG-Dicarboxylic Acids & -Esters

PEG1985 DIG(Pfp)2

CAS-No. 158573-58-1

Formula C16 H4F 10 O

PEG1990 DIG(NHS)2

2,2‘-Oxydiacetic acid bis-N-succinimidyl ester

CAS-No. 373614-12-1

Formula

PEG2035 DOODA

3,6-Dioxaoctanedioic acid

CAS-No. 23243-68-7

Formula C 6 H10 O 6

PEG2030 TUDA

3,6,9-Trioxaundecandioic acid

CAS-No. 13887-98-4

Formula C 8 H14O 7

Mol.

222,19 g/mol

PEG4120

NHS-PEG(2)-NHS

3,6-Dioxaoctandioic acid bissuccinimidyl ester

CAS-No. 65869-63-8

Formula C16 H20 N2O 10

Mol. weight 400,34 g/mol

PEG4875

HOOC-dPEG™(3)-COOH

Diethyleneglycol-bis(propionic acid)

CAS-No. 96517-92-9

Formula C10 H18 O 7 Mol. weight 250,25 g/mol

PEG4130

NHS-PEG(3)-NHS

3,6,9-Trioxaundecandioic acid bissuccinimidyl ester

CAS-No. 1314378-16-9

Formula C18 H24N

Mol. weight 444,39 g/mol

PEG4880

HOOC-dPEG™(4)-COOH

Tetraethyleneglycol-bis(propionic acid)

CAS-No. 31127-85-2

Formula C12H22O 8 Mol. weight 294,30 g/mol

PEG3960

NHS-dPEG™(4)-NHS

Bis-succinimidyl-4,7,10,13-tetraoxahexadecane-1,16-dioate

CAS-No. 1314378-11-4

Formula C 20 H28 N2O

PEG4041 Tfp-dPEG™(4)-Tfp

alpha,omega-Bis(tertrafluorphenyl propionate) tri(ethylene glycol)

Formula C 24H22F8 O 8

PEG5090

NHS-dPEG™(5)-COOH

Succinimidyl-4,7,10,13,16-pentaoxanonadecane-1,19-dicarboxylic acid

CAS-No. 1343476-41-4

Formula C18 H

NO

PEG1435

NHS-dPEG(5)-NHS

Bis-succinimidyl-4,7,10,13,16-pentaoxanonadecane-1,19-dioate

CAS-No. 756526-03-1

Formula C 22H32N

PEG2115

NHS-PEG(5)-CO-OBzl

alpha-succinimidyl ester-omega-carboxy benzyl ester penta(ethylene

CAS-No. 1263044-84-3

Formula C 25H35NO 11

PEG3970

NHS-dPEG™(7)-NHS

Bis-succinimidyl-4,7,10,13,16,19,22-heptaoxa pentacosane-1,25-dioate

CAS-No. 1334170-02-3

PEG7710

NHS-dPEG™(9)-COOH

alpha-succinimidyl nona(ethylen glycol)-alpha,omega-bispropionic acid

PEG1460

NHS-dPEG(9)-NHS

Bis-succinimidyl-4,7,10,13,16,19,22,25,28-nonaoxahentriacontane-1,31-dioate

CAS-No. 1008402-79-6

Formula C 30 H48 N2O

PEG1091

HOOC-PEG(13)-COOH

alpha,omega-Bis(propionic acid) tridecae(ethylene glycol)

PEG5100

NHS-dPEG™(13)-COOH

alpha-succinimidyl trideca(ethylene glycol)-alpha,omega-bispropionic

PEG3980 NHS-dPEG™(13)-NHS

alpha,omega-bis(succinimidyl propionate) do -

PEG3990 NHS-dPEG™(17)-NHS

alpha,omega-bis(succinimidyl propionate) hexadeca(ethylene

PEG4000 NHS-dPEG™(21)-NHS

alpha,omega-bis(succinimidyl propionate) 20(ethylene glycol)

PEG7720 NHS-dPEG™(25)-COOH

alpha-succinimidyl 25(ethylen glycol)-alpha,omega-bispropionic acid

PEG4010

NHS-dPEG™(25)-NHS

alpha,omega-bis(succinimidyl propionate) 24(ethylene glycol)

CAS-No. 1008402-79-6

Formula C 62H112N

PEG4110

Tfp-dPEG™(25)-Tfp

alpha,omega-Bis(2,3,4,5-tetrafluorphenyl propionate) 25(ethylene glycol)

PEG1083

HOOC-PEG-COOH (2 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

PEG1085

HOOC-PEG-COOH (3 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

PEG1086

HOOC-PEG-COOH (6 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

PEG1082

HOOC-PEG-COOH (10 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

PEG1084

HOOC-PEG-COOH (20 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

PEG1184

NHS-PEG-NHS (2 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

PEG1186

NHS-PEG-NHS (3 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

PEG1187

NHS-PEG-NHS (6 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

PEG1183

NHS-PEG-NHS (10 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

PEG1185

NHS-PEG-NHS (20 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

PEGylation

3.3. Methoxy-PEG and other Alkyl-PEG-Acids & -Esters

PEG2020 DOHA

3,6-Dioxaheptaneoic acid

CAS-No. 16024-56-9

Formula C 5H10 O4

Mol. weight 134,13 g/mol

PEG1630 MeO-EPr-COOH

3-(2-Methoxyethoxy)propanoic acid, 4,7-Dioxa-octanoic acid

CAS-No. 149577-05-9

Formula C 6 H12O4

Mol. weight 148,16 g/mol

PEG1905 MeO-EPr-NHS

3-(2-Methoxyethoxy)propanoic acid succinimidyl ester

CAS-No. 1127247-34-0

Formula C10 H15NO 6

Mol. weight 245,23 g/mol

PEG5240 t BuO-Ethoxyacetic acid

2-(2-t-butoxyethoxy)acetic acid

CAS-No. 1566691-57-3

Formula C 8 H16 O4

Mol. weight 176,21 g/mol

PEG5250 t BuO-EEA

2-(2-(2-t-butoxyethoxy)ethoxy)acetic acid

CAS-No. 1993217-96-1

Formula C10 H20 O 5

Mol. weight 220,26 g/mol

PEG4990 Palm-AEEA

{2-[2-(Palmitoyl-amino)ethoxy]ethoxy}acetic acid

CAS-No. 1570043-00-3

Formula C 22H43 NO 5

Mol. weight 401,58 g/mol

PEG1203

Stea-O2Oc-OH

8-(Stearoylamido)-3,6-dioxaoctanoic acid

CAS-No. 1006054-22-3

Formula C 24H47NO 5

Mol. weight 429,65 g/mol

PEG1620

MeO-dPEG(3)-COOH

2,5,8,11-Tetraoxatetradecan-14-oic acid

CAS-No. 67319-28-2

Formula C10 H20 O 6

Mol. weight 236,26 g/mol

PEG1880

MeO-dPEG(3)-NHS

2,5,8,11-Tetraoxatetradecan-14-oic acid succinimidyl ester

CAS-No. 174569-25-6

Formula C14H23 NO 8

Mol. weight 333,33 g/mol

PEG1625

MeO-dPEG(8)-COOH

2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid

CAS-No. 1093647-41-6

Formula C18 H36 O 10

Mol. weight 412,47 g/mol

PEG1885

MeO-dPEG(8)-NHS

2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid succinimidyl ester

CAS-No. 756525-90-3

Formula C 22H39 NO 12

Mol. weight 509,54 g/mol

PEG1156

MeO-PEG(12)-COOH

2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaoctatriacontan-38-oic acid

CAS-No. 2135793-73-4

Formula C 26 H 52O 14

Mol. weight 588,68 g/mol

PEG1890

MeO-dPEG(12)-NHS

2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaoctatriacontan-38-oic acid succinimidyl ester

CAS-No. 2207596-93-6

Formula C 30 H 55NO 16 Mol. weight 685,75 g/mol

PEG7420

MeO-dPEG™(12)-TFP

2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaoctatriacontan-38-oic acid 2,3,5,6-tetrafluorophenyl ester

Formula C 224H422N10 O

PEG7430

MeO-dPEG™(24)-TFP

alpha-Methoxy-23(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG1640

MeO-PEG(25)-COOH

alpha-Methoxy-24(ethylen glycol)-omega-propionic acid

CAS-No. 125220-94-2

Formula C 52H104O 27

PEG1902

MeO-PEG(25)-NHS

alpha-Methoxy-24(ethylene glycol)-omega-propionic acid succinimidyl ester

CAS-No. 174569-25-6

Formula C 56 H107NO 29

PEG7440

MeO-dPEG™(25)-TFP

alpha-Methoxy-24(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG2320

NHS-PEG(4)-[PEG(8)-OMe] 3

Succinimidyl-PEG(4)-[PEG(8)-OMe] 3

CAS-No. 1333154-74-7

Formula C 84H158 N 6 O

PEG5030

TFP-PEG(4)-[mPEG(11)] 3

Tetrafluorphenyl carboxylate-PEG(4)-[PEG(10)-OMe] 3

PEG3210

MeO-dPEG™(37)-COOH

alpha-Methoxy-37(ethylene glycol)-omega-propionic acid

PEG3190

MeO-dPEG™(37)-NHS

alpha-Methoxy-37(ethylene glycol)-omega-propionic acid succinimidyl ester

CAS-No. 174569-25-6

Formula C 80 H155NO41

PEG3221 MeO-dPEG™(48)-COOH

alpha-Methoxy-48(ethylene glycol)-omega-propionic acid

PEG7450

MeO-dPEG™(48)-TFP

alpha-Methoxy-47(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

Formula C108 H203 F4NO

Mol. weight 2407,74 g/mol

PEG1161

MeO-PEG-COOH (750 Da)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2

Mol. weight 750 Da

PEG1158

MeO-PEG-COOH (2 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2

Mol. weight 2000 Da

PEG1160

MeO-PEG-COOH (5 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2

Mol. weight 5000 Da

PEG1157

MeO-PEG-COOH (10 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2

Mol. weight 10000 Da

PEG1159

MeO-PEG-COOH (20 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2

Mol. weight 20000 Da

PEG1166

MeO-PEG-NHS (750 Da)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

Mol. weight 750 Da

PEG1163

MeO-PEG-NHS (2 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

Mol. weight 2000 Da

PEG1165

MeO-PEG-NHS (5 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG1162

MeO-PEG-NHS (10 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

PEG1164

MeO-PEG-NHS (20 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG6610

HO-PEG-SQA (3 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

PEGylation

PEG6615 HO-PEG-SQA (5 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG6600 HO-PEG-SQA (10 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6605 HO-PEG-SQA (20 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG6640 MeO-PEG-SQA (750 Da)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 750 Da

PEG6625 MeO-PEG-SQA (2 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 2000 Da

PEG6635 MeO-PEG-SQA (5 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

Product details

PEG6620

MeO-PEG-SQA (10 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6630

MeO-PEG-SQA (20 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

3.4. PEG-Acids & -Esters with other Terminal Functionalities

Product details

PEG7610

Bromoacetamido-PEG(4)-TFP

Bromoacetamido-tetra(ethylene glycol)-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG7620

Bromoacetamido-PEG(12)-TFP

Bromoacetamido-dodeca(ethylene glycol)-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG7630

Bromoacetamido-PEG(24)-TFP

Bromoacetamido-24(ethylene glycol)-propionic acid 2,3,5,6-tetrafluorophenyl ester

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PEG6980

DOTA-PEG(3)-bromoacetamide*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-tri(ethylene glycol)-omega-maleimido bistrifluo-

PEG6990

DOTA-PEG(11)-bromoacetamide*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-undeca(ethylene glycol)-omega-maleimido bistrifluoroacetate

PEG7000

DOTA-PEG(23)-bromoacetamide*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-23(ethylene glycol)-omega-maleimido bistrifluoroacetate

PEG5080 Phth-NO-dPEG™(4)-NHS

1-Phthalimidoxy-3,6,9,12-tetraoxapentadecan-15-oic acid succinimdyl ester

PEG4630

Phth-NO-dPEG™(12)-NHS

alpha-Pthaloylaminoxy-omega-(succinimidyl propionate)-dodeca(ethylene glycol)

PEG4690

FB-dPEG(12)™-TFP

alpha-( p-Formylbenzoylamido)-omega-[(2,3,5,6-tetrafluorophenyl)propionate]-dodeca(ethylene glycol)

PEG4700

FB-dPEG(24)™-TFP

alpha-( p-Formylbenzoylamido)-omega-[(2,3,5,6-tetrafluorophenyl)propionate]-24(ethylene glycol)

PEG1223

ACA-PEG-NHS

(3 kDa)

alpha-Acryloyl-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG1224

ACA-PEG-NHS

(5 kDa)

alpha-Acryloyl-omega-carboxy succinimidyl ester poly(ethylene

PEG1222

ACA-PEG-NHS

(10 kDa)

alpha-Acryloyl-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1208

Epoxy-PEG-COOH (3 kDa)

alpha-Epoxy-omega-carboxy poly(ethylene glycol)

weight 3000 Da

RL-4040

PFB-mercaptopropionyl-AEEA

Perfluorobiphenyl-mercaptopropionyl-AEEA

RL-4050

PFB-mercaptopropionyl-TOTA-Biotin

Perfluorobiphenyl-mercaptopropionyl-TOTA-Biotin

RL-4030

PFB-mercaptopropionyl-PEG3-N3

Perfluorobiphenyl-mercaptopropionyl-PEG(3)-N

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4. PEG-Amines, -Hydrazines and -Guanidines

.

4.1. Mono-Protected PEG-Diamines

BNN1017 Boc-EDA*HCl

N-t-Butyloxycarbonyl-ethylenediamine hydrochloride

CAS-No. 79513-35-2

Formula C 7H16 N2O 2*HCl

PEG7920

Boc-NH-ethoxy-ethylamine

1-(Boc-amino)-3-oxa-5-pentaneamine

CAS-No. 127828-22-2

Formula C9 H20 N2O 3 Mol. weight 204,27 g/mol

BNN1016 Boc-DOOA

1-(t-Butyloxycarbonyl-amino)-3,6-dioxa-8-octaneamine, liq.

CAS-No. 153086-78-3

Formula C11H24N2O4

BNN1058 Boc-DSOA*HCl

1-(t-Butyloxycarbonyl-amino)-3,6-dithio-8-octaneamine hydrochloride

CAS-No. 1301739-93-4

Formula C11H24N2O 2 S 2*HCl

280,45*36,45 g/mol

BNN1015 Boc-DODA

1-(t-Butyloxycarbonyl-amino)-4,9-dioxa-12-dodecanamine, liq.

CAS-No. 101187-29-5

Formula C15H32N2O4 Mol. weight 304,43 g/mol

BNN1028 Boc-TOTA

1-(t-Butyloxycarbonyl-amino)-4,7,10-trioxa-13-tridecanamine, liq.

CAS-No. 194920-62-2

Formula C15H32N2O 5

Mol. weight 320,43 g/mol

PEG7870

Boc-NH-PEG(3)-NH2

1-(t-Butyloxycarbonyl)amino-3,6,9-trioxa-undecan-11amine

CAS-No. 101187-40-0

Formula C13 H28 N2O 5

Mol. weight 292,37 g/mol

PEG6835

Boc-NH-PEG(3)-NH2*HCl

tert-butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy) ethyl)carbamate

CAS-No. 101187-40-0 net

Formula C13 H28 N2O 5*HCl

Mol. weight 292,38*36,46 g/mol

PEG7880 Boc-NH-PEG(4)-NH2

1-(t-Butyloxycarbonyl)amino-3,6,9,12-tetraoxatetradecan-14-amine

CAS-No. 811442-84-9

Formula C15H32N2O 6 Mol. weight 336,42 g/mol

PEG7890

Boc-NH-PEG(5)-NH2

1-(t-Butyloxycarbonyl)amino-3,6,9,12,15-pentaoxaheptadecan-17-amine

CAS-No. 189209-27-6

Formula C17H36 N2O 7 Mol. weight 380,48 g/mol

PEG1066 Boc-NH-PEG(7)-NH2

alpha-Amino-omega-Boc-amino-hepta(ethylene glycol)

CAS-No. 206265-98-7

Formula C 21H44N2O 9 Mol. weight 468,59 g/mol

PEG1065

Boc-NH-PEG(11)-NH2

alpha-Amino-omega-Boc-amino-undecae(ethylene glycol)

CAS-No. 198227-38-2

PEG4660

Amino-dPEG™(11)-aminoxy-Boc

alpha-Amino-omega-(t-butyloxycarbonyl-aminoxy)-undeca(ethylene glycol)

PEG7690

Boc-NH-PEG(23)-NH2

alpha-Amino-omega-Boc-amino-23(ethylene glycol)

PEG1068

Boc-NH-PEG-NH2 (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol)

PEG1069

Boc-NH-PEG-NH2 (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol)

PEG1067

Boc-NH-PEG-NH2 (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol)

PEG1335 H2 N-dPEG(4)-NHNH-Boc

15-Amino-4,7,10,13-tetraoxa-pentadecanoyl-N‘-(t-butyloxycarbonyl)-hydrazid

CAS-No. 1263047-17-1

Formula C16 H33 N3 O 7

Mol. weight 379,45 g/mol

PEG4230 H2 N-dPEG™(8)-NHNH-Boc

alpha-Amino-omega-(N‘-(t-butyloxycarbonyl)hydrazido propionate) octa(ethylene glycol)

CAS-No. 1334169-96-8

Formula C 24H49 N3 O 11

Mol. weight 555,66 g/mol

PEG4240 H2 N-dPEG™(12)-NHNH-Boc

alpha-Amino-omega-(N‘-(t-butyloxycarbonyl)hydrazido propionate) dodeca(ethylene glycol)

CAS-No. 1334169-97-9

Formula C 32H 65N3 O 15

PEG7340 H2 N-PEG(4)-Lys(Boc)-NH-PEG(24)-OMe

N-alpha-(amino-tetra(ethylene glycol))-epsilon-(t-butyloxycarbonyl)-L-lysine alpha-(mPEG(24)) ester

Formula C 71H142N4O 32 Mol. weight 1563,89 g/mol

PEG1805 Fmoc-NH-dPEG(4)-NHNH-Boc

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoyl-N‘-(t-butyloxycarbonyl)hydrazid

CAS-No. 1263044-77-4

Formula C 31H43 N3 O 9

Mol. weight 601,69 g/mol

FNN1008 Fmoc-EDA*HCl

N1-(9-Fluorenylmethyloxycarbonyl)-ethylenediamine hydrochloride

CAS-No. 391624-46-7

Formula C17H18 N2O 2*HCl

Mol. weight 318,8 g/mol

FNN1007 Fmoc-DOOA*HCl

1-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxa-8-octaneamine hydrochloride

CAS-No. 868599-73-9

Formula C 21H26 N2O4*HCl

Mol. weight 370,45*36,45 g/mol

FNN1006

Fmoc-DODA*HCl

1-(9-Fluorenylmethyloxycarbonyl-amino)-4,9-dioxa-12-dodecanamine hydrochloride

CAS-No. 1274891-99-4

Formula C 25H34N2O4*HCl

Mol. weight 426,56*36,45 g/mol

FNN1011

Fmoc-TOTA*HCl

1-(9-Fluorenylmethyloxycarbonyl-amino)-4,7,10-trioxa-13-tridecanamine hydrochloride

CAS-No. 868599-75-1

Formula C 25H34N2O 5*HCl

Mol. weight 442,56*36,45 g/mol

RL-4390 Fmoc-NH-PEG(3)-NH2*HCl

(9H-fluoren-9-yl)methyl (2-(2-(2-(2-aminoethoxy) ethoxy)ethoxy)ethyl)carbamate hydrochloride

CAS-No. 906079-91-2

Formula C 23 H30 N2O 5*HCl

Mol. weight 414,50*36,45 g/mol

PEG1745 Z-TOTA

1-Benzyloxycarbonyl-4,7,10-trioxa-13-tridecaneamine

CAS-No. 220156-99-0

Formula C18 H30 N2O 5

Mol. weight 354,44 g/mol

PEG7910 Z-NH-dPEG(11)-NH2

1-Benzyloxycarbonylamino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-35-amine

Formula C 32H 58 N2O 13

Mol. weight 678,81 g/mol

PEGylation

4.2. Unprotected PEG-Diamines

PEG1204 H2 N-PEG(7)-NH2

alpha,omega-Bis-amino octa(ethylene glycol)

CAS-No. 332941-25-0

Formula C16 H36 N2O 7

Mol. weight 368,47 g/mol

PEG1500 H2 N-dPEG(11)-NH2

N1,N19-bis(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy) propyl)-4,7,10,13,16-pentaoxanonadecane-1,19-diamide

CAS-No. 1224728-09-9

Formula C 34H70 N4O 13 Mol. weight 742,94 g/mol

PEG2001 H2 N-PEG(27)-NH2

alpha,omega-Bis-amino 27(ethylene glycol)

CAS-No. 24991-53-5

Formula C 56 H116 N2O 27 Mol. weight 1249,52 g/mol

PEG1002 H2 N-PEG-NH2 (2 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 2000 Da

PEG1004 H2 N-PEG-NH2 (3 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 3000 Da

PEG1005 H2

N-PEG-NH2 (6 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 6000 Da

PEG1001 H2

N-PEG-NH2 (10 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 10000 Da

PEG1003

H2 N-PEG-NH2 (20 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 20000 Da

4.3. Amino-PEG-Alcohols

PEG1320 H2 N-PEG(4)-OH

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol

CAS-No. 86770-74-3

Formula C 8 H19 NO4

Mol. weight 193,24 g/mol

PEG1340 H2

N-dPEG(8)-OH

23-Amino-3,6,9,12,15,18,21-heptaoxatrieicosane-1-ol

CAS-No. 352439-37-3

Formula C16 H35NO 8

Mol. weight 369,45 g/mol

PEG1310 H2 N-dPEG(12)-OH

35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol H2N

CAS-No. 933789-97-0

Formula C 24H 51NO 12

Mol. weight 545,66 g/mol

PEG1315 H2 N-dPEG(12)-O-DMT

35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-(4,4‘-dimethoxytrityl)ether

CAS-No. 879571-23-0

Formula C 45H 69 NO 14

Mol. weight 848,03 g/mol

PEG3740 H2 N-dPEG™(24)-OH

alpha-Amino-omega-hydroxy 24(ethylene glycol) H2N

CAS-No. 933789-97-0

Formula C 48 H99 NO 24 Mol. weight 1074,29 g/mol

PEG3750 H2 N-dPEG™(36)-OH

alpha-Amino-omega-hydroxy 36(ethylene glycol) H2N

CAS-No. 933789-97-0

Formula C 72H147NO 36 Mol. weight 1602,92

PEG1007 H2 N-PEG-OH (3 kDa)

alpha-Amino-omega-hydroxy poly(ethylene glycol)

CAS-No. 32130-27-1

Mol. weight 3000 Da

PEG1008 H2 N-PEG-OH (5 kDa)

alpha-Amino-omega-hydroxy poly(ethylene glycol)

CAS-No. 32130-27-1

Mol. weight 5000 Da

PEG1006 H2 N-PEG-OH (10 kDa) alpha-Amino-omega-hydroxy poly(ethylene glycol)

CAS-No. 32130-27-1

Mol. weight 10000 Da

BAL1048 Boc,Pbf-amidino-EtOH

2-[N-t-Butyloxycarbonyl-N‘-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)amidino]ethanol

CAS-No. 1263048-99-2

Formula C 21H33 N3 O 6 S

Mol. weight 455,57 g/mol

BAL1047 Boc,Pbf-amidino-EEtOH

2-{2-[N-t-Butyloxycarbonyl-N‘-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)amidino]ethoxy}ethanol

CAS-No. 1263049-12-2

Formula C 23 H37N3 O 7S

Mol. weight 499,61 g/mol

PEG1915 Boc-NH-PEG(4)-OH

2-(2-(2-(2-(t-Butyloxycarbonylamino)ethoxy)ethoxy) ethoxy)ethanol

CAS-No. 106984-09-2

Formula C13 H27NO 6

Mol. weight 293,36 g/mol

PEG7860 Boc2-AEEEE

2-(2-(2-(2-(Di-(t-butylmethyloxycarbonyl))aminoethoxy) ethoxy)ethoxy)ethanol

CAS-No. 2389064-37-1

Formula C18 H35NO 8

Mol. weight 393,47 g/mol

PEG5385 Boc,Z-AEEEE

2-(2-(2-(2-(Benzyloxycarbonyl-tert-Butylmethyloxycarbonyl)aminoethoxy)ethoxy)ethoxy)ethanol

CAS-No. 2389064-46-2

Formula C 21H33 NO 8

Mol. weight 427,49 g/mol

PEGylation

PEG1960 Boc-NH-dPEG(12)-OH

35-(t-Butyloxycarbonylamino)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol

CAS-No. 159156-95-3

Formula C 29 H 59 NO 14

Mol. weight 645,78 g/mol

PEG1021 Boc-NH-PEG-OH (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-hydroxy poly(ethylene glycol)

Mol. weight 3000 Da

PEG1022 Boc-NH-PEG-OH (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-hydroxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1020 Boc-NH-PEG-OH (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-hydroxy poly(ethylene glycol)

Mol. weight 10000 Da

PEG1030 HO-PEG-CONH-NH-Boc (3 kDa)

alpha-Hydroxy-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 3000 Da

PEG1031 HO-PEG-CONH-NH-Boc (5 kDa)

alpha-Hydroxy-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 5000 Da

Product details

PEG1029 HO-PEG-CONH-NH-Boc (10 kDa) alpha-Hydroxy-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 10000 Da

FAL3010 Fmoc-O1Pen-ol

5-(9-Fluorenylmethyloxycarbonyl-amino)-3-oxa-1-pentanol

CAS-No. 299430-87-8

Formula C19 H21NO4

Mol. weight 327,37 g/mol

PEG5370 Fmoc-AEEE

2-(2-(2-(9-Fluorenylmethyloxycarbonyl)aminoethoxy) ethoxy)ethanol

CAS-No. 560088-66-6

Formula C 21H25NO 5

Mol. weight 371,43 g/mol

PEG5380 Fmoc-AEEEE

2-(2-(2-(2-(9-Fluorenylmethyloxycarbonyl)aminoethoxy)ethoxy)ethoxy)ethanol

CAS-No. 868594-41-6

Formula C 23 H29 NO 6

Mol. weight 415,48 g/mol

4.4. Methoxy-PEG-Amines

PEG1685

MeO-PEG(4)-NH2

2,5,8,11-Tetraoxatridecan-13-amine

CAS-No. 85030-56-4

Formula C9 H21NO4

Mol. weight 207,27 g/mol

Product details

PEG1730

MeO-PEG(7)-NH2

2,5,8,11,14,17,20-heptaoxadocosan-22-amine

Formula C15H33 NO 7

Mol. weight 339,43 g/mol

PEG1700

MeO-PEG(8)-NH2

2,5,8,11,14,17,20,23-Octaoxapentacosan-25-amine

CAS-No. 869718-81-0

Formula C17H37NO 8

Mol. weight 383,48 g/mol

PEG1655

MeO-PEG(12)-NH2

2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatriacontan-37-amine

CAS-No. 32130-27-1

Formula C 25H 53 NO 12 Mol. weight 559,69 g/mol

PEG3290

MeO-dPEG™(15)-NH2

alpha-Methoxy-omega-amino-15(ethylene glycol)

CAS-No. 32130-27-1

Formula C 31H 65NO 15 Mol. weight 691,85

PEG1670

MeO-dPEG(24)-NH2

alpha-Methoxy-omega-amino-24(ethylene glycol)

CAS-No. 32130-27-1

Formula C 49 H101NO 24

PEG3300

MeO-dPEG™(36)-NH2

alpha-Methoxy-omega-amino-36(ethylene glycol)

CAS-No. 32130-27-1

Formula C 73 H149 NO 36 Mol.

PEG3310

MeO-dPEG™(48)-NH2

alpha-Methoxy-omega-amino-48(ethylene glycol)

CAS-No. 32130-27-1

Formula C97H197NO48

Mol. weight 2145,58 g/mol

PEG7380

H2 N-PEG(12)-[PEG(24)-OMe]

Amino-PEG(12)-[PEG(24)-OMe] 3

Formula C187H373 N 5 O 91

Mol. weight 4147,94 g/mol

PEG1155

MeO-PEG-NH2 (750 Da)

alpha-Methoxy-omega-amino poly(ethylene glycol)

PEG1152

MeO-PEG-NH2 (2 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

PEG1154

MeO-PEG-NH2 (5 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

PEG1151

MeO-PEG-NH2 (10 kDa)

alpha-Methoxy-omega-amino

PEG1153 MeO-PEG-NH2 (20 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

Mol. weight 20000 Da

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. 5. PEGs Functionalized for Click-Chemistry

5.1. PEG-Alkynes

PEG1935 Propargyl-NHS

3-(Prop-2-ynyloxy)propanoic acid succinimidyl ester

CAS-No. 1174157-65-3

PEG5430 Alkyne-PEG(4)-NH2

PEG2960

H2 N-PEG-alkyne (3 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

PEG2980

H2 N-PEG-alkyne (5 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

PEG2950

H2 N-PEG-alkyne (10 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

PEG2970 H2 N-PEG-alkyne (20 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 20000 Da

PAA1050 Poc-O2Oc-OH*DCHA

8-(Popargylyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylamine

Formula C10 H15NO 6*C12H23 N

Mol. weight 245,23*181,32 g/mol

PEG5410 Alkyne-PEG(4)-NHS

Alkyne-PEG(4)-succinimidyl ester

CAS-No. 1393330-40-9

Formula C18 H27NO 9

Mol. weight 401,41 g/mol

PEG5440 Alkyne-PEG(4)-mal

Alkyne-PEG(4)-maleimide

CAS-No. 1609651-90-2

Formula C18 H26 N2O 7

Mol. weight 382,41 g/mol

PEG6815 Alkyne-O2Oc-OH

Pentynoyl-8-amino-3,6-dioxaoctanoic acid

CAS-No. 2134622-80-1

Formula C11H17NO 5

Mol. weight 243,26 g/mol

PEG8170 Propargyl-PEG(5)-COOH

4,7,10,13,16-pentaoxanonadec-18-ynoic acid

CAS-No. 1245823-51-1

Formula C14H24O 7

Mol. weight 304,34 g/mol

PEG2860

NHS-PEG-alkyne (3 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene glycol)

PEG2880

NHS-PEG-alkyne (5 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene glycol)

PEG2850

NHS-PEG-alkyne (10 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene

PEG2870

NHS-PEG-alkyne (20 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido

PEG6570

Alkynyl-PEG-SQA (3 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

PEG6575

Alkynyl-PEG-SQA (5 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

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PEG6560 Alkynyl-PEG-SQA (10 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6565 Alkynyl-PEG-SQA (20 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG4950

Biotin-PEG(4)-alkyne

15-[D(+)-Biotinylamino]-4,7,10,13-tetraoxapentadec-1-yne

CAS-No. 1262681-31-1

Formula C 21H35N3 O 6 S

Mol. weight 457,58

PEG6805 Biotin-PEG3-NH-Pentynoyl

alpha-Biotin-omega-pentynoyl 3(ethylene glycol)

CAS-No. 869082-82-6

Formula C 23 H38 N4O 6 S

Mol. weight 498,64 g/mol

PEG8010 Biotin-PEG(4)-Alkyne

(3aS,4S,6aR)-4-(5,21-dioxo-8,11,14,17-tetraoxa-4,20diazapentacos-1-yn-25-yl)tetrahydro-1H-thieno[3,4-d] imidazol-2(3H)-one

CAS-No. 1006592-45-5

Formula C 24H40 N4O 7S

Mol. weight 528,66 g/mol

PEG8110 Biotin-PEG(4)-SS-Alkyne

N-(2-((3-oxo-3-(prop-2-ynylamino)propyl)disulfanyl)ethyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide

CAS-No. 1260247-54-8

Formula C 29 H49 N 5 O 8 S 3

Mol. weight 691,92 g/mol

PEG7980 Biotin-PEG(4)-Dde-Alkyne

N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12tetraoxa-16-azanonadec-18-ynyl)-5-((3aS,4S,6aR)-2oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1802908-00-4

Formula C 32H 50 N4O 8 S

Mol. weight 650,83 g/mol

PEG3110 I-PEG-alkyne (3 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

PEG3120 I-PEG-alkyne (5 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 5000 Da

PEG3090 I-PEG-alkyne (10 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 10000 Da

PEG3100 I-PEG-alkyne (20 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

PEG2840 MeO-PEG-alkyne (750 Da)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

CAS-No. 1993176-75-2

Mol. weight 750 Da

PEG2810 MeO-PEG-alkyne (2 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 2000 Da

PEG2830

MeO-PEG-alkyne (5 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

PEG2800

MeO-PEG-alkyne (10 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 10000 Da

PEG2820

MeO-PEG-alkyne (20 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

PEG4810 Alkyne-PEG-Si(OMe)3 (3 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

PEG4815 Alkyne-PEG-Si(OMe)3 (5 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 5000 Da

Product details

PEG4820 Alkyne-PEG-Si(OMe)3 (10 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 10000 Da

PEG4825 Alkyne-PEG-Si(OMe)3 (20 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 20000 Da

RL-3940 Alkyne-PEG(5)-SNAP

N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide

5.2. PEG-DBCO

RL-2480

DBCO-PEG(3)-BisSulfonThiol-Linker

Dibenzoazacyclooctyne-PEG(3)-BisSulfon-Thiol-Linker

Product details

PEG6740 DBCO-PEG(4)-TFP

Dibenzoazacyclooctyne-tetra(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

O

PEG6765

DBCO-PEG(36)-TFP

Dibenzoazacyclooctyne-36(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

Formula

RL-2420

DBCO-PEG(4)-NH2*TFA

Dibenzoazacyclooctyne-tetra(ethylene glycol)-amine trifluoro acetic acid salt

CAS-No. 1255942-08-5 net

Formula C 29 H37N3 O 6*C 2F 3 HO 2

RL-2421

DBCO-Sulfo-PEG(4)-NH2

Dibenzoazacyclooctyne-tetra(ethylene glycol)amine

CAS-No. 2055198-05-3

PEG6790

Bromoacetamido-PEG(4)-DBCO

Bromoacetamido-tetra(ethylene glycol)-amido-dibenzoazacyclooctyne

RL-2520

Biotin-PEG(4)-DBCO

Dibenzoazacyclooctyne-tetra(ethylene glycol)-biotin

CAS-No. 1255942-07-4

Formula C 39 H 51N 5 O

Mol.

PEG8140 Biotin-PEG(4)-Dde-DBCO

N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo19-(azadibenzocyclooctyn-1-yl)-3,6,9,12-tetraoxa-16azanonadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1807512-43-1

Formula C 47H 61N 5 O 9 S

Mol. weight 872,08 g/mol

PEG8120

Biotin-PEG(4)-SS-DBCO N-(2-((3-(3-(azadibenzocyclooctyn-1-yl)-3-oxopropylamino)-3-oxopropyl)disulfanyl)ethyl)-1-(5-((3aS,4S,6aR)2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-am ide

Formula C 44H 60 N 6 O 9 S 3

RL-2500

DBCO-PEG(4)-mal

Dibenzoazacyclooctyne-tetra(ethylene glycol)-maleimide

CAS-No. 1480516-75-3

Formula C 36 H42N4O 9

weight 674,74 g/mol

PEG6785

DBCO-PEG(36)-MAL

Dibenzoazacyclooctyne-36(ethylene glycol)-maleimide

RL-2510

DBCO-PEG(4)-OH

Dibenzoazacyclooctyne-tetra(ethylene glycol)

CAS-No. 1416711-60-8 Formula

RL-2450

DBCO-PEG(5)-COOH

Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid

RL-2460

DBCO-PEG(5)-NHS

Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid succinimidyl ester

CAS-No. 1378531-80-6

Formula C 36 H43 N3 O 11

PEG6800

Bromoacetamido-PEG(12)-DBCO

Bromoacetamido-dodeca(ethylene glycol)-amido-dibenzoazacyclooctyne

PEG7465

Me-PEG(12)-DBCO

Methyl-12(ethylene glycol)-amido-dibenzoazacyclooctyne

PEG6770

DBCO-PEG(12)-MAL

Dibenzoazacyclooctyne-dodeca(ethylene glycol)-maleimide

PEG6750

DBCO-PEG(12)-TFP

Dibenzoazacyclooctyne-dodeca(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

PEG6810

Bromoacetamido-PEG(24)-DBCO

Bromoacetamido-24(ethylene glycol)-amido-dibenzoazacyclooctyne

PEG6780 DBCO-PEG(24)-MAL

Dibenzoazacyclooctyne-24(ethylene glycol)-maleimide

PEG6760

DBCO-PEG(24)-TFP

Dibenzoazacyclooctyne-24(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

CAS-No. 2754372-40-0

Formula C 77H118 F4N

PEG6785

DBCO-PEG(36)-MAL

Dibenzoazacyclooctyne-36(ethylene glycol)-maleimide

PEG6765

DBCO-PEG(36)-TFP

Dibenzoazacyclooctyne-36(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

PEG6830

DBCO-dPEG(12)-(5)6-carboxyfluorescein

Dibenzoazacyclooctyne-dodeca(ethylene glycol)-(5)6-carboxyfluorescein

PEG7460

DBCO-PEG(24)-OMe

alpha-Methoxy-24(ethylene glycol)-amido-dibenzoazacyclooctyne

RL-2530 DBCO-mPEG (5kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5

Mol. weight 5000 Da

PEGylation

RL-2540

DBCO-mPEG (10kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5

Mol. weight 10000 Da

Product details

RL-2550

DBCO-mPEG (20kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5

Mol. weight 20000 Da

RL-2560

DBCO-mPEG (30kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5

Mol. weight 30000 Da

5.3. PEG-Azides

PEG4980 H2 N-PEG(2)-N3*TosOH

2-[2-(2-Azidoethoxy)ethoxy]ethanaminium tosylat

CAS-No. 2173092-98-1

Formula C 7H14N4O 2*C 7H 8 O 3 S

Mol. weight 174,20*172,20 g/mol

Product details

PEG4960 Boc-NH-PEG(2)-N3

1-(t-Butyloxycarbonyl-amino)-3,6-dioxa-8-octaneazide

CAS-No. 950683-55-3

Formula C11H22N4O4

Mol. weight 274,32 g/mol

BAA4920 Boc-Aoa-NH-PEG3-N3

tert-butyl ((14-azido-2-oxo-6,9,12-trioxa-3-azatetradecyl)oxy)carbamate

CAS-No. 1803191-52-7

Formula C15H29 N

Mol. weight 391,43 g/mol

BNN1150 N3 -TOTA

1-Azido-4,7,10-trioxa-13-tridecanamine

CAS-No. 1162336-72-2

Formula C10 H22N4O 3

Mol. weight 246,31 g/mol

PEG3060

H2 N-PEG(3)-N3

1-Amino-11-azido-3,6,9-trioxaundecane

CAS-No. 134179-38-7

Formula C 8 H18 N4O 3 Mol. weight 218,25 g/mol

PEG8160

N3 -PEG(3)-NH-Boc

t-Butyl N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl) carbamate

CAS-No. 642091-68-7

Formula C13 H26 N4O

Mol. weight 318,37 g/mol

RL-4380 Fmoc-NH-PEG(3)-N3 (9H-fluoren-9-yl)methyl (2-(2-(2-(2-azidoethoxy)ethoxy) ethoxy)ethyl)carbamate

CAS-No. 1172605-58-1

Formula C 23 H28 N4O 5

Mol. weight 440,50 g/mol

PEG5320 N3 -PEG(4)-NH2

14-Azido-3,6,9,12-tetraoxatetradecan-1-amine

CAS-No. 951671-92-4

Formula C10 H22N4O4

PEG1087 H2 N-PEG(6)-N3

alpha-Amino-omega-azido hexa(ethylene glycol)

CAS-No. 957486-82-7

Formula C14H30 N4O 6

Mol. weight 350,42 g/mol

PEG2350 H2 N-PEG(7)-N3

alpha-Amino-omega-azido hepta(ethylene glycol)

CAS-No. 1333154-77-0

Formula C16 H34N4O 7

Mol. weight 394,46 g/mol

PEG3050 H2 N-PEG(8)-N3

alpha-Amino-omega-azido octa(ethylene glycol)

CAS-No. 857891-82-8

Formula C18 H38 N4O 8

PEG1081 H2 N-PEG(11)-N3

alpha-Amino-omega-azido undecae(ethylene glycol)

CAS-No. 1800414-71-4

Formula C 24H 50 N4O 11

PEG3070 H2 N-PEG(23)-N3

alpha-Azido-omega-amino 23(ethylene glycol)

CAS-No. 2172677-19-7

Formula C 48 H98 N4O 23 Mol.

PEG3080 H2 N-PEG(35)-N3

alpha-Azido-omega-amino 35(ethylene glycol)

CAS-No. 749244-38-0

Formula C 72H146 N4O 35

Mol.

PEG3010 H2 N-PEG-N3 (3 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

Mol. weight 3000 Da

PEG3030 H2 N-PEG-N3 (5 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

PEG3000 H2 N-PEG-N3 (10 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

PEG3020 H2 N-PEG-N3 (20 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

Mol. weight 20000 Da

PEG2780 N3 -O2Oc-OH*CHA [2-(2-azidoethoxy)ethoxy]acetic acid cyclohexylamine

CAS-No. 2098500-94-6

Formula C 6 H11N3 O4*C 6 H13 N

weight 189,17*99,17 g/mol

PEG7950 N3 -AEEA-OK

Potassium 8-azido-3,6-dioxaoctanoate

CAS-No. 882518-90-3 net

Formula C 6 H10 KN3 O4

PEG5390 N3 -O2Oc-Ot Bu

8-Azido-3,6-dioxaoctanoic acid t-butyl ester

CAS-No. 251564-45-1

Formula C10 H19 N3 O4

Mol. weight 245,28 g/mol

PEG5000 N3 -TFBA-O2Oc

{2-[2-(4-Azido-2,3,5,6-tetrafluorobenzoyl-amino)ethoxy] ethoxy}acetic acid

CAS-No. 1993119-45-1

Formula C13 H12F4N4O 5

Mol. weight 380,25 g/mol

PEG5400 N3 -AEEEA*CHA

11-Azido-3,6,9-trioxaundecanoic acid cyclohexylamine

CAS-No. 172531-37-2 net

Formula C 8 H15N3 O 5*C 6 H13 N

Mol. weight 233,22*99,17 g/mol

RL-4320 N3 -PEG(3)-NH-Suc

1-azido-13-oxo-3,6,9-trioxa-12-azahexadecan-16-oic acid

CAS-No. 1202400-17-6

Formula C12H22N

Mol. weight 318,33 g/mol

PEG5170 N3 -TOTA-Suc

1-Azido-4,7,10-trioxa-13-tridecaneamine succinamic acid

CAS-No. 1993176-74-1

Formula C14H26 N4O 6 Mol. weight 346,38 g/mol

RL-4370 N3 -PEG(3)-NH-DIG-OH

Diglycolic acid PEG3 azide

CAS-No. 239081-53-9

Formula C12H22N4O 7

Mol. weight 334,33 g/mol

PEG2345

N3 -PEG(4)-COOH

15-Azido-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 1257063-35-6

Formula C11H21N3 O 6

Mol. weight 291,3 g/mol

PEG1400

N3 -dPEG(4)-NHS

15-Azido-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 944251-24-5

Formula C15H24N4O 8

Mol. weight 388,37 g/mol

PEG2790

N3 -O2Oc-O2Oc-OH

8-(8-Azido-3,6-dioxaoctanoylamido)-3,6-dioxaoctanoic acid

CAS-No. 1254054-60-8

Formula C12H22N4O 7

Mol. weight 334,33 g/mol

PEG4170

N3 -PEG™(8)-COOH

alpha-Azido-omega-(propionic acid) octa(ethylene glycol)

CAS-No. 1214319-92-2

Formula C19 H37N3 O 10 Mol. weight 467,51 g/mol

PEG1405 N3 -dPEG(8)-NHS

1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester

CAS-No. 1204834-00-3

Formula C 23 H40 N4O 12 Mol.

PEG2015

N3 -PEG(9)-COOH

O-(2-Azidoethyl)-O-[2-(diglycolyl-amino)ethyl]heptaethylene glycol

CAS-No. 846549-37-9

Formula C 22H42N4O 12

PEG4180

N3 -PEG™(12)-COOH

alpha-Azido-omega-(propionic acid) dodeca(ethylene glycol)

CAS-No. 1167575-20-3 Formula C

PEG1395

N3 -dPEG(12)-NHS

1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid succinimidyl ester

CAS-No. 1108750-59-9

Formula C 31H 56 N4O 16

PEG4190

N3 -dPEG™(24)-COOH

alpha-Azido-omega-(propionic acid) 24(ethylene glycol)

CAS-No. 1167575-20-3

PEG7650 N3

-dPEG™(24)-TFP

alpha-Azido-omega-(2,3,5,6-tetrafluorophenyl propionate) 24(ethylene glycol)

PEG7660 N3

-dPEG™(36)-TFP

alpha-Azido-omega-(2,3,5,6-tetrafluorophenyl propionate) 36(ethylene glycol)

PEG6655 N3 -PEG-SQA (3 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

PEG6660 N3 -PEG-SQA (5 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG6645 N3 -PEG-SQA (10 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6650 N3 -PEG-SQA (20 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG4900 N3 -EEEt-OH

2-[2-(2-Azidoethoxy)ethoxy]ethanol

CAS-No. 86520-52-7

Formula C 6 H13 N

175,19 g/mol

PEG3760 N3 -PEG(3)-OH

alpha-Azido-omega-hydroxy tetra(ethylene glycol)

CAS-No. 86770-67-4

Formula C 8 H17N3 O4

Mol. weight 219,24 g/mol

PEG5300 N3 -PEG(4)-OH

2-(2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethoxy) ethanol

CAS-No. 86770-68-5

Formula C10 H21N3 O 5

Mol. weight 263,29 g/mol

PEG6720

N3 -PEG(5)-OH

17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-ol

CAS-No. 86770-69-6

Formula C12H25N3 O 6

Mol. weight 307,34 g/mol

PEG1088

N3 -PEG(8)-OH

alpha-Azido-omega-hydroxy octa(ethylene glycol)

CAS-No. 352439-36-2

Formula C16 H33 N3 O 8

Mol. weight 395,45 g/mol

PEG1390

N3 -dPEG(12)-OH

35-Azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol

CAS-No. 73342-16-2

Formula C 24H49 N3 O 12 Mol. weight 571,66 g/mol

PEG3770

N3 -dPEG™(24)-OH

alpha-Azido-omega-hydroxy 24(ethylene glycol)

CAS-No. 73342-16-2

Formula C 48 H97N3 O 24 Mol. weight 1100,29 g/mol

PEG3780

N3 -dPEG™(36)-OH

alpha-Azido-omega-hydroxy 36(ethylene glycol)

CAS-No. 73342-16-2

Formula C 72H145N3 O 36 Mol. weight 1628,92 g/mol

PEG4940 Biotin-PEG(3)-N3

11-[D(+)-Biotinylamino]-1-azido-3,6,9-trioxaundecane

CAS-No. 875770-34-6

Formula C18 H32N 6 O 5 S

Mol. weight 444,55 g/mol

PEG6795 Biotin-PEG3-Ph(4-N3)

Biotin-PEG3-phenyl azide

CAS-No. 2088238-77-9

Formula C 25H37N7 O 6 S

Mol. weight 563,67 g/mol

PEG7990 Biotin-PEG(4)-N3

(3aS,4S,6aR)-4-(28-azido-5,21-dioxo-9,12,15,18-tetraoxa-6,22-diazaoctacosyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one

CAS-No. 1006592-62-6

Formula C 27H49 N7 O 7S

Mol. weight 615,79 g/mol

PEG8000 Biotin-PEG(4)-Picolyl-N3

(3aS,4S,6aR)-4-(1-(6-(azidomethyl)pyridin-3-ylamino)1,17-dioxo-4,7,10,13-tetraoxa-16-azahenicosan-21-yl) tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one

CAS-No. 2222687-71-8

Formula C 27H42N 8 O 7S

Mol. weight 622,74 g/mol

PEG8100

Biotin-PEG(4)-SS-Azide N-(2-((3-((3-azidopropyl)amino)-3-oxopropyl)disulfaneyl)ethyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide

CAS-No. 1260247-52-6

Formula C 29 H 52N 8 O 8 S 3 Mol. weight 736,96 g/mol

PEG7960 Biotin-PEG(4)-Dde-N3

N-(19-azido-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12-tetraoxa-16-azanonadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1802907-93-2

Formula C 32H 53 N7 O 8 S Mol. weight 695,87 g/mol

PEG7970

Biotin-PEG(4)-Dde-Picolyl-N3

N-(6-(azidomethyl)pyridin-3-yl)-15-(4,4-dimethyl-2,6dioxocyclohexylidene)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxa-16-azanonadecan-19-amide

CAS-No. 2055048-42-3

Formula C 38 H 57N9 O 9 S Mol.

PEG4330

Biotin-dPEG™(7)-N3

alpha-Biotin-omega-azido hepta(ethylene glycol)

CAS-No. 1334172-75-6

Formula C 26 H48 N 6 O 9 S Mol. weight 620,76 g/mol

PEG4340

Biotin-dPEG™(11)-N3

[2-(2-aminoethoxy)ethoxy]acetic acid tert-butyl ester*HCl

CAS-No. 956494-20-5

Formula C 34H 64N 6 O 13 S Mol.

PEG4350

Biotin-dPEG™(23)-N3

alpha-Biotin-omega-azido 23(ethylene glycol)

CAS-No. 956494-20-5

Formula C 58 H112N 6 O

PEG7190

Bromoacetamido-PEG(3)-N3

Bromoacetamido-tri(ethylene glycol)-azide

CAS-No. 940005-81-2

Formula C10 H19 BrN4O4

PEG7200

Bromoacetamido-PEG(11)-N3

Bromoacetamido-undeca(ethylene glycol)-azide

Formula C 26 H 51BrN4O

PEG7210 Bromoacetamido-PEG(23)-N3

Bromoacetamido-23(ethylene glycol)-azide

1220,24

RL-3700

Halo-PEG(2)-Azide

CAS-No. 2568146-55-2

Formula C10 H20 ClN3 O 2

PEG3150 I-PEG-N3 (3 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

PEG3160 I-PEG-N3 (5 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

PEG3130 I-PEG-N3 (10 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

PEG3140 I-PEG-N3 (20 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

PEG1690

MeO-dPEG(4)-N3

13-Azido-2,5,8,11-tetraoxa-tridecane

CAS-No. 606130-90-9

Formula C9 H19 N3 O4

Mol. weight 233,26 g/mol

PEG1705

MeO-dPEG(8)-N3

25-Azido-2,5,8,11,14,17,20,23-octaoxapentacosane

Formula C17H35N3 O 8

PEG1660

MeO-dPEG(12)-N3

37-Azido-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontane

CAS-No. 2170098-29-8

Formula C 25H 51N3 O 12 Mol. weight 585,69 g/mol

PEG1710

MeO-dPEG(24)-N3

alpha-Methoxy-omega-azido-24(ethylene glycol)

CAS-No. 89485-61-0

Formula C 49 H99 N3 O

PEG5350

HO-PEG-N3 (3 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

PEG5360

alpha-Hydroxy-omega-azido poly(ethylene glycol)

PEG5330 HO-PEG-N3 (10 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

Mol. weight 10000 Da

PEG5340 HO-PEG-N3 (20 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

PEG3430 MeO-dPEG™(36)-N3

alpha-Methoxy-omega-azido-36(ethylene glycol)

CAS-No. 89485-61-0

Formula C 73 H147N3 O 36 Mol. weight 1642,95 g/mol

PEG1219 MeO-PEG-N3 (750 Da)

alpha-Methoxy-omega-azido poly(ethylene glycol)

PEG1225 MeO-PEG-N3 (2 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

PEG2040 MeO-PEG-N3 (5 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

PEG2045 MeO-PEG-N3 (10 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

PEG2050 MeO-PEG-N3 (20 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

PEG4830 Azido-PEG-Si(OMe)3 (3 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

PEG4835 Azido-PEG-Si(OMe)3 (5 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

PEG4840 Azido-PEG-Si(OMe)3 (10 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

PEG4845 Azido-PEG-Si(OMe)3 (20 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

RL-3960 Azide-PEG(4)-SNAP

N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-1-azido-3,5,7,9-tetraoxadodecan-12-amide

RL-4030 PFB-mercaptopropionyl-PEG3-N3

Perfluorobiphenyl-mercaptopropionyl-PEG(3)-N

RL-3935 Mal-PEG(3)-N3

N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3-(2,5dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide

CAS-No. 1858264-36-4

Formula C15H23 N 5 O 6

Mol. weight 369,38 g/mol

5.4. PEG-TCO

TCO1070 TCO-PEG(3)-NH2*HCl

trans-Cyclooctene-PEG(3)-amine

CAS-No. 2028288-77-7

Formula C19 H36 N2O 5*HCl Mol. weight 372,51*36,46 g/mol

TCO1040 TCO-PEG(4)-COOH

trans-Cyclooctene-PEG(4)-Acid

CAS-No. 1802913-21-8

Formula C 20 H35NO 8

PEGylation

TCO1010

TCO-PEG(4)-NHS

trans-Cyclooctene-PEG(4)-carboxy succinimidyl ester

CAS-No. 1621096-79-4

Formula C 24H38 N2O

PEG2065

Biotin-TEG-ATFBA

Biotin-triethylenglycol-( p-azido-tetrafluorobenzamide)

CAS-No. 1264662-85-2

Formula C 27H37F4N7 O

TCO1020

TCO-PEG(12)-NHS

trans-Cyclooctene-PEG(12)-carboxy succinimidyl ester

CAS-No. 2185016-39-9

Formula C 40 H70 N

Product details

TCO1050

TCO-PEG(3)-mal

trans-Cyclooctene-PEG(3)-maleimide

CAS-No. 1809356-72-6

Formula C 26 H41N3 O

5.5. PEG-Tetrazines

RL-2310

MeTz-PEG(4)-COOH

Methyltetrazine-PEG(4)-acid

CAS-No. 1802907-91-0

Formula C 20 H28 N4O 7 Mol.

Product details

RL-2330

MeTz-PEG(4)-NHS

Methyltetrazine-PEG(4)-propanoyl succinimidyl ester

CAS-No. 1802907-92-1

Formula C 24H31N 5 O 9

Mol. weight 533,53 g/mol

RL-2590

Tz-benzoyl-TOTA*TFA

Tz-benzoyl-TOTA*TFA

RL-3905

MeTz-PEG(4)-STP

sodium 2,3,5,6-tetrafluoro-4-((1-(4-(6-methyl-1,2,4,5tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oyl)oxy)benzenesulfonate

Formula C 26 H27F4N4NaO

RL-2370 MeTz-PEG(4)-NH2*HCl

Methyltetrazine-PEG(4)-amine HCL salt

CAS-No. 1802908-05-9 net

RL-2380 MeTz-mPEG (5kDa)

alpha-Methyltetrazine-omega-methoxy-poly(ethylene glycol)

RL-2390 MeTz-mPEG (10kDa)

alpha-Methyltetrazine-omega-methoxy-poly(ethylene glycol)

PEGylation

RL-2400 MeTz-mPEG (20kDa)

alpha-Methyltetrazine-omega-methoxy-poly(ethylene glycol)

Mol. weight 20000 Da

Product details

RL-2340

MeTz-PEG(4)-mal

Methyltetrazine-PEG(4)-maleimide

CAS-No. 1802908-02-6

Formula C 24H30 N

Mol. weight 514,53 g/mol

5.6. Tri-functional PEG Cross-Linkers with Click Reactivity

PEG2910

NHS-PEG(NH-Boc)-alkyne (3 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 3000

Product details

PEG2930

NHS-PEG(NH-Boc)-alkyne (5 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 5000 Da

PEG2900

NHS-PEG(NH-Boc)-alkyne (10 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 10000 Da

PEG2920

NHS-PEG(NH-Boc)-alkyne (20 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 20000 Da

PEG2915

NHS-PEG(NH-Fmoc)-alkyne (3 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 3000 Da

PEG2935

NHS-PEG(NH-Fmoc)-alkyne (5 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 5000 Da

PEG2905

NHS-PEG(NH-Fmoc)-alkyne (10 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 10000 Da

PEG2925

NHS-PEG(NH-Fmoc)-alkyne (20 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 20000 Da

PEGylation

. 6. Biotin-PEG Reagents

Interested in biotin reagents with click functionality? Please browse through chapter 5 PEGs Functionalized for Click-Chemistry

6.1. Biotin-PEG-Acids & -Esters

PEG2560

Biotin-O2Oc-OH

8-Biotinylamido-3,6-dioxaoctanoic acid

CAS-No. 1238575-77-3

Formula C16 H27N

Product details

PEG5280

Biotin-TOTA-glutaramic acid*DIPEA

5,21-dioxo-25-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)-10,13,16-trioxa-6,20-diazapentacosan-1-oic acid diisopropylethylamine salt

CAS-No. 1205744-09-7

Formula C 25H44N4O 8 S*C 8 H19 N

Mol. weight 560,70*129,30 g/mol

PEG2565 Biotin-O2Oc-O2Oc-OH

8-Biotinylamido-3,6-dioxaoctanoic acid dimer

CAS-No. 1301706-65-9

Formula C 22H38 N4O 9 S

Mol. weight 534,62 g/mol

PEG1515 Biotin-PEG(4)-COOH

15-Biotinamino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 721431-18-1

Formula C 21H37N3 O 8 S

Mol. weight 491,6 g/mol

PEG1870

Biotin-dPEG(4)-NHS

15-Biotinamino-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 459426-22-3

Formula C 25H40 N

weight 588,67 g/mol

PEG8090 Biotin-PEG(4)-SS-COOH

9,25-dioxo-29-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosan-1-oic acid

CAS-No. 1380166-80-2

Formula C 26 H46 N4O 9 S 3 Mol. weight 654,86 g/mol

PEG4440

Fmoc-L-Lys(dPEG™(4)-Biotin)-OH

N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[15-(biotinamido)-4,7,10,13-tetraoxa-pentadecanoyl]-L-lysine

CAS-No. 1334172-64-3

Formula C 42H 59 N 5 O 11 S

Mol. weight 842,01 g/mol

PEG2071 Biotin-TEG-TFP

Biotin-tetra(ethylene glycol)-2,3,5,6-tetrafluorphenyl

PEG1845 Biotin-dPEG(4)-NHS-(Biotinidase resistant)

18-Biotinamino-17-oxo-4,7,10,13-tetraoxa-16-azaicosan1-oic acid succinimidyl ester

CAS-No. 1334172-61-0

Formula C 29 H47N 5 O 11 S Mol. weight 673,78 g/mol

PEG7760 Biotin-dPEG™(4)-TFP-(Biotinidase resistant)

18-Biotinamino-17-oxo-4,7,10,13-tetraoxa-16-azaicosan1-oic acid (2,3,5,6-tetrafluorophenyl) ester

PEG1910

Biotin-dPEG(4)-S-S-NHS

1-Biotinamino-15-oxo-3,6,9,12-tetraoxa-19,20-dithia-16-azatricosan-23-oic acid succinimidyl ester

CAS-No. 1260247-51-5

Formula C 30 H49 N

Mol. weight 751,93 g/mol

PEG6690

Biotin-PEG(6)-COOH

21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid

CAS-No. 1352814-10-8

Formula C 25H45N

Mol. weight 579,7 g/mol

PEG1051

Biotin-PEG(12)-COOH

alpha-Biotin-omega-(propionic acid)-dodecae(ethylene glycol)

CAS-No. 948595-11-7

Formula C 37H 69 N3 O

PEG1860

Biotin-dPEG(12)-NHS

alpha-Biotin-omega-carboxy succinimidyl ester dodeca(ethylene glycol)

CAS-No. 365441-71-0

Formula C 41H72N4O 18 S Mol. weight 941,09 g/mol

PEG5130

Biotin-PEG(12)-TFP

alpha-Biotin-omega-propionic acid (2,3,5,6-tetrafluorophenyl) ester dodeca(ethylene glycol)

PEG7770

Biotin-dPEG™(12)-TFP-(Biotinidase resistant)

alpha-Biotinyl-(2-aminobutyryl)-omega-(2,3,5,6-tetrafluorophenyl propionate) dodeca(ethylene glycol)

Formula C 47H76 F4N4O 17S Mol.

PEG4450 Fmoc-L-Lys(dPEG™(12)-Biotin)-OH N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[alpha-Biotin-omega-propionyl dodeca(ethylene glycol)]-L-lysine

CAS-No. 1334172-65-4

Formula C

weight 1194,43 g/mol

PEG4260

Biotin-dPEG™(24)-COOH

alpha-Biotin-omega-(propionic acid) 24(ethylene glycol)

CAS-No. 721431-18-1

Formula C 61H117N

PEG4250

Biotin-dPEG™(24)-NHS

alpha-Biotin-omega-(succinimidyl propionate) 24(ethylene glycol)

CAS-No. 365441-71-0

Formula C 65H120 N4O 30 S Mol.

PEG7750

Biotin-dPEG™(24)-TFP

alpha-Biotin-omega-(2,3,5,6-tetrafluorophenyl propionate) 24(ethylene glycol)

PEG4270

Biotin-dPEG™(48)-COOH

alpha-Biotin-omega-(propionic acid) 48(ethylene glycol)

CAS-No. 721431-18-1

Formula C112H218 N4O 53 S

PEG1053

Biotin-PEG-COOH (3 kDa)

alpha-Biotin-omega-carboxy poly(ethylene glycol)

PEG1054 Biotin-PEG-COOH (5 kDa)

alpha-Biotin-omega-carboxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1052

Biotin-PEG-COOH (10 kDa)

alpha-Biotin-omega-carboxy poly(ethylene glycol)

PEG1056 Biotin-PEG-NHS (3 kDa)

alpha-Biotin-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1057

Biotin-PEG-NHS (5 kDa)

alpha-Biotin-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG1055 Biotin-PEG-NHS (10 kDa)

alpha-Biotin-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6590 Biotin-PEG-SQA (3 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 3000 Da

Product details

PEG6595 Biotin-PEG-SQA (5 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG6580 Biotin-PEG-SQA (10 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6585 Biotin-PEG-SQA (20 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

6.2. Biotin-PEG-Amines & -Hydrazines

PEG2760 Biotin-DOOA*HCl

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride

CAS-No. 862373-14-6

Formula C16 H30 N4O4 S*HCl

Mol. weight 374,50*36,45 g/mol

Product details

RL-4060 Biotin-DOOA

Biotinyl-1-amino-3,6-dioxa-8-octanamine

CAS-No. 138529-46-1

Formula C16 H30 N4O4 S

Mol. weight 374,50 g/mol

RL-4210

Biotin-PEG(3)-NH2

N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]biotinamide

CAS-No. 359860-27-8

Formula C18 H34N4O

Mol. weight 418,22 g/mol

PEG8050 Biotin-TOTA

N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide

CAS-No. 183896-00-6

Formula C 20 H38 N4O 5 S

PEG2110 Biotin-dPEG™(3)-NH2*TFA

N-Biotin-3,3‘-(2,2‘-oxybis(ethane-2,1-diyl)bis(oxy)) dipropan-1-amine trifluoroacetate

CAS-No. 1334172-59-6

Formula C 20 H38 N4O 5 S*CF 2CO 2H Mol. weight 446,60*114,01 g/mol

PEG5140 Biotin-TEG-O-NH2*HCl

N-(2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy) ethyl)-5-biotinamide hydrochloride

Formula C18 H34N4O 6 S*HCl Mol. weight 434,55*36,45 g/mol

PEG1425 Biotin-dPEG(4)-NHNH2

15-Biotinamino-4,7,10,13-tetraoxa-pentadecanoyl hydrazide

CAS-No. 756525-97-0

Formula C 21H39 N 5 O 7S Mol. weight 505,63

PEG4290 Biotin-dPEG™(7)-NH2 alpha-Biotin-omega-amino hepta(ethylene glycol)

CAS-No. 1334172-76-7

Formula C 26 H 50 N4O 9 S

PEG1044

Biotin-PEG(9)-NH2

alpha-Biotin-omega-amino-nona(ethylene glycol)

CAS-No. 960132-48-3

Formula C 30 H 58 N4O 11 S

Mol. weight 682,88 g/mol

PEG4300

Biotin-dPEG™(11)-NH2

alpha-Biotin-omega-amino undeca(ethylene glycol)

CAS-No. 604786-74-5

Formula C 34H 66 N4O 13 S Mol. weight 770,97 g/mol

PEG4680

Biotin-dPEG™(11)-O-NH2*HCl

alpha-Biotinyl-omega-oxyamine-undeca(ethylene glycol)

PEG4310

Biotin-dPEG™(23)-NH2

alpha-Biotin-omega-amino 23(ethylene glycol)

CAS-No. 604786-74-5

Formula C 58 H114N

PEG1046

Biotin-PEG-NH2 (3 kDa)

alpha-Biotin-omega-amino poly(ethylene glycol)

PEG1047 Biotin-PEG-NH2 (5 kDa)

alpha-Biotin-omega-amino poly(ethylene glycol)

PEG1045 Biotin-PEG-NH2 (10 kDa)

alpha-Biotin-omega-amino poly(ethylene glycol)

Mol. weight 10000 Da

6.3. Biotin-PEG-Alcohols & -Thiols

LS-3490 Biotin-AEEA-Tyramide

N-(2-(2-(2-(4-hydroxyphenethylamino)-2-oxoethoxy) ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 2561473-92-3

Formula C

PEG8130 Biotin-PEG(4)-Dde-Tyramide

N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-18-(4hydroxyphenyl)-3,6,9,12-tetraoxa-16-azaoctadecyl)5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d] imidazol-4-yl)pentanamide

PEG1206 Biotin-PEG-OH (3 kDa)

alpha-Biotin-omega-hydroxy poly(ethylene glycol)

Mol. weight 3000 Da

PEG1207

Biotin-PEG-OH (5 kDa)

alpha-Biotin-omega-hydroxy poly(ethylene glycol)

LS-4260

Biotin-PEG(3)-SH

N-(17-mercapto-15-oxo-4,7,10-trioxa-14-azaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1208242-09-4

Formula C 23 H42N4O

2 Mol. weight 534,73 g/mol

LS-4240

Biotin-PEG(3)-SS-Py

N-(15-oxo-17-(pyridin-2-yldisulfaneyl)-4,7,10-trioxa-14azaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

Formula C 28 H45N 5 O 6 S 3 Mol. weight 643,88 g/mol

PEG4705 Biotin-PEG(11)-SH

alpha-Biotin-omega-mercapto undeca(ethylene glycol)

PEG1213 Biotin-PEG-SH (3 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

Mol. weight 3000 Da

PEG1214 Biotin-PEG-SH (5 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

Mol. weight 5000 Da

PEG1212 Biotin-PEG-SH (10 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

PEG1226 Biotin-PEG-SH (20 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

Mol. weight 20000 Da

PEG4770

Biotin-PEG-OPSS (3 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 3000 Da

PEG4775

Biotin-PEG-OPSS (5 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 5000 Da

PEG4780

Biotin-PEG-OPSS (10 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

PEG4785 Biotin-PEG-OPSS (20 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

6.4. Biotin-PEG-Maleimides

PEG1605

Biotin-PEG(3)-mal

N-(3-(2-(2-(3-(Biotinamino)propoxy)ethoxy)ethoxy) propyl)-3-maleimidylpropanamide

CAS-No. 525573-22-2

Formula C 27H43 N 5 O 8 S

Mol. weight 597,72 g/mol

PEG1595

Biotin-dPEG(11)-mal

alpha-Biotin-omega-maleimido undeca(ethylene glycol)

CAS-No. 1334172-60-9

Formula C 41H71N 5 O 16 S

Mol. weight 922,09 g/mol

PEG4320

Biotin-dPEG™(23)-mal

alpha-Biotin-omega-maleimido 23(ethylene glycol)

CAS-No. 1334172-60-9

Formula C 65H119 N 5 O 28 S

Mol. weight 1450,72 g/mol

PEG1049

Biotin-PEG-mal (3 kDa)

alpha-Biotin-omega-maleimido poly(ethylene glycol)

3000 Da

PEG1050

Biotin-PEG-mal (5 kDa)

alpha-Biotin-omega-maleimido poly(ethylene glycol)

PEG1048 Biotin-PEG-mal (10 kDa)

alpha-Biotin-omega-maleimido poly(ethylene glycol)

Mol.

10000 Da

PEGylation

6.5. Other Biotin-PEG Reagents

PEG2080 Biotin-TEG-Biotin

N,N‘-Bisbiotin-tetra(ethylene glycol)-diamine

CAS-No. 1263044-47-8

Formula C 30 H 52N 6 O

Mol. weight 672,9 g/mol

PEG4850 Biotin-PEG-Si(OMe)3 (3 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 3000 Da

PEG4855 Biotin-PEG-Si(OMe)3 (5 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 5000 Da

PEG4860 Biotin-PEG-Si(OMe)3 (10 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 10000 Da

PEG4865 Biotin-PEG-Si(OMe)3 (20 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

RL-4050 PFB-mercaptopropionyl-TOTA-Biotin

Perfluorobiphenyl-mercaptopropionyl-TOTA-Biotin

Formula C 35H41F9 N4O 6 S 2

Mol. weight 848,84 g/mol

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PEG2065

Biotin-TEG-ATFBA

Biotin-triethylenglycol-( p-azido-tetrafluorobenzamide)

CAS-No. 1264662-85-2

Formula C 27H37F4N7 O

S

Mol. weight 663,68 g/mol

PEG6805

Biotin-PEG3-NH-Pentynoyl

alpha-Biotin-omega-pentynoyl 3(ethylene glycol)

CAS-No. 869082-82-6

Formula C 23 H38 N4O 6 S Mol.

RL-4250

Biotin-PEG(4)-Gly-CBT

15-Biotinylamino-4,7,10,13-tetraoxa-pentadecanoyl-glycinyl-N-2-cyano-benzothiazole

CAS-No. 1907639-46-6

Formula C 31H43 N7 O 8 S 2 Mol.

PEG6795

Biotin-PEG3-Ph(4-N3)

Biotin-PEG3-phenyl azide

CAS-No. 2088238-77-9

.

Find many more Biotinylation Regents in our brochure

PEGylation

. 7. PEG Thiols & Thiol-Reactive PEG Reagents

7.1. Mercapto-PEG-Acids & -Esters

PEG1970 HS-dPEG(4)-COOH

15-Mercapto-4,7,10,13-tertaoxa-pentadecanoic acid

CAS-No. 749247-06-1

Formula C11H22O 6 S

PEG6710

Trt-S-PEG(4)-COOH*H2O

15-Tritylmercapto-4,7,10,13-tetraoxapentadecanoic acid monohydrate

CAS-No. 882847-05-4 net

Formula C 30 H36 O 6 S*H

PEG1945 Ac-S-dPEG(4)-NHS

15-Acetylthio-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 937025-17-7

Formula C17H27NO 9 S

Mol. weight 421,46 g/mol

PEG1740 Mmt-S-dPEG(4)-COOH

15-(4-Methoxytrityl)thio-4,7,10,13-tertaoxa-pentadecanoic acid

CAS-No. 1263047-31-9

Formula C 31H38 O 7S

Mol. weight 554,69 g/mol

PEG2230 OPSS-PEG(4)-NHS

N-[3-(o-Pyridyldisulfido)propanoyl]-15-amino-4,7,10,13-tetraoxa-pentadecanoyl succinimidyl ester

CAS-No. 1334177-95-5

Formula C 23 H33 N3 O 9 S 2

PEG1120

HS-PEG(8)-COOH

alpha-Thio-omega-(propionic acid) octa(ethylene glycol)

CAS-No. 866889-02-3

Formula C19 H38 O 10 S

Mol. weight 458,57 g/mol

PEG1955

Ac-S-dPEG(8)-NHS

1-Acetylthio-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester

CAS-No. 1070798-99-0

Formula C 25H43 NO 13 S

Mol. weight 597,67 g/mol

PEG1735

Mmt-S-dPEG(8)-COOH

alpha-(4-Methoxytrityl)thio-octa(ethylene glycol)-omega-propionic acid

CAS-No. 1334177-82-0

Formula C 39 H 54O 11 S

Mol. weight 730,91 g/mol

PEG2240

OPSS-PEG(8)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester octa(ethylene glycol)

CAS-No. 1252257-56-9

Formula C 31H49 N3 O 13 S

PEG1119

HOOC-PEG(8)-SS-PEG(8)-COOH

Propionic acid octa(ethylene glycol)-disulfid

CAS-No. 873013-93-5

Formula C 38 H74O 20 S 2 Mol. weight 915,11

PEG1188 NHS-PEG(8)-SS-PEG(8)-NHS

N-Hydroxy-succinimidy-propionate octa(ethylene glycol)-disulfid

CAS-No. 947601-98-1

Formula C 46 H 80 N2O 24 S 2 Mol.

PEG2000 HS-FA-PEG(12)-COOH

alpha-(11-Mercapto-undecanoylamido)-omega-carboxy dodeca(ethylene glycol)

Formula C 38 H75NO 15 S Mol.

PEG3440

HS-dPEG™(12)-COOH

alpha-Thio-omega-(propionic acid) dodeca(ethylene glycol)

CAS-No. 1032347-93-5

Formula C 27H 54O 14 S Mol. weight 634,77

PEG3630 Ac-S-dPEG™(12)-NHS

alpha-Acethylthio-omega-(succinimidyl propionate) dodeca(ethylene glycol)

CAS-No. 1334169-95-7

Formula C 33 H 59 NO 17S

PEG4600 Mmt-S-dPEG™(12)-COOH

alpha-(4-Methoxytrityl)thio-dodeca(ethylene glycol)-omega-propionic acid

CAS-No. 1334169-94-6

Formula C 47H70 O 15 S Mol.

PEG2250 OPSS-PEG(12)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester dodeca(ethylene glycol)

CAS-No. 924280-65-9

Formula C 39 H 65N3 O 17S 2 Mol.

PEG5060 Ac-S-dPEG™(24)-NHS

alpha-Acethylthio-omega-(succinimidyl propionate) 24(ethylene glycol)

Formula C 57H107NO 29 S Mol.

PEG2260 OPSS-PEG(24)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester 24(ethylene glycol)

CAS-No. 924280-65-9

Formula C 63 H113 N3 O 29 S 2

Mol. weight 1440,7 g/mol

PEG7900

OPSS-PEG(30)-NHS

alpha-(o-Pyridyldisulfido)-omega-succinimidyl propionate 30(ethylene glycol)

Formula C 72H132N2O 34 S 2 Mol. weight 1633,94 g/mol

PEG3920 OPSS-dPEG™(36)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-(succinimidyl propionate) 36(ethylene glycol)

CAS-No. 924280-65-9

Formula C 87H161N3 O41 S 2 Mol. weight 1969,33 g/mol

PEG1099 HS-PEG-COOH (3 kDa)

alpha-Thio-omega-carboxy poly(ethylene glycol)

PEG1100 HS-PEG-COOH (5 kDa)

alpha-Thio-omega-carboxy poly(ethylene glycol)

PEG1098 HS-PEG-COOH (10 kDa)

alpha-Thio-omega-carboxy poly(ethylene glycol)

PEG1216 OPSS-PEG-NHS (3 kDa)

alpha-Pyridyl-2-disulfid-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG1217 OPSS-PEG-NHS (5 kDa)

alpha-Pyridyl-2-disulfid-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG1215 OPSS-PEG-NHS (10 kDa)

alpha-Pyridyl-2-disulfid-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG4720 OPSS-PEG-NHS (20 kDa)

alpha-Pyridyl-2-disulfid-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG1200 Trt-S-PEG-NHS (3 kDa)

alpha-Tritylthio-omega-carboxy succinimidyl ester poly(ethylene glycol)

weight 3000 Da

PEG1201 Trt-S-PEG-NHS (5 kDa)

alpha-Tritylthio-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG1199 Trt-S-PEG-NHS (10 kDa)

alpha-Tritylthio-omega-carboxy succinimidyl ester poly(ethylene glycol)

PEG6675 Trt-S-PEG-SQA (3 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid

ethyl ester poly(ethylene glycol)

PEG6680 Trt-S-PEG-SQA (5 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid

ethyl ester poly(ethylene glycol)

PEG6665 Trt-S-PEG-SQA (10 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid

ethyl ester poly(ethylene glycol)

PEG6670 Trt-S-PEG-SQA (20 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid

ethyl ester poly(ethylene glycol)

PEGylation

7.2. Mercapto-PEG-Amines & -Hydrazines

PEG1197 H2 N-PEG-SH*HCl

(3 kDa)

alpha-Amino-omega-mercapto poly(ethylene glycol)

hydrochloride

Mol. weight 3000 Da

PEG1198 H2 N-PEG-SH*HCl (5

kDa)

alpha-Amino-omega-mercapto poly(ethylene glycol)

hydrochloride

Mol. weight 5000 Da

PEG1196 H2 N-PEG-SH*HCl

(10 kDa)

alpha-Amino-omega-mercapto poly(ethylene glycol)

Mol. weight 10000 Da

PEG1027 H2 N-PEG-Strt

(3 kDa)

alpha-Amino-omega-tritylthio poly(ethylene glycol)

Mol. weight 3000 Da

PEG1028 H2 N-PEG-Strt (5 kDa)

alpha-Amino-omega-tritylthio poly(ethylene glycol)

Mol. weight 5000 Da

PEG1026 H2 N-PEG-Strt (10 kDa)

alpha-Amino-omega-tritylthio poly(ethylene glycol)

Mol. weight 10000 Da

PEG1114

Boc-NH-PEG-SH (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-mercapto poly(ethylene glycol)

Mol. weight 3000 Da

PEG1115

Boc-NH-PEG-SH (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-mercapto poly(ethylene glycol)

Mol. weight 5000 Da

PEG1113

Boc-NH-PEG-SH (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-mercapto poly(ethylene glycol)

Mol. weight 10000 Da

PEG1102

HS-PEG-CONH-NH-Boc (3 kDa)

alpha-Thio-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

PEG1103

HS-PEG-CONH-NH-Boc (5 kDa)

alpha-Thio-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 5000 Da

PEG1101

HS-PEG-CONH-NH-Boc (10 kDa)

alpha-Thio-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 10000 Da

PEGylation

7.3. Hydroxy- & Methoxy-PEG-Thiols

PEG7010 Trt-S-EEE

S-Trityl-2-(2-(2-mercaptoethoxy)ethoxy)ethanol

CAS-No. 728033-15-6

Formula C 25H28 O 3 S

Mol. weight 408,55 g/mol

PEG6730 Trt-S-EEEE

S-Trityl-2-(2-(2-(2-mercaptoethoxy)ethoxy)ethoxy)

ethanol

CAS-No. 125607-10-5

Formula C 27H32O4 S Mol. weight 452,61 g/mol

PEG2095 Ac-S-TEG-OH

S-Acetyl-mercapto-tetra(ethylene glycol)

CAS-No. 223611-42-5

Formula C10 H20 O 5 S Mol.

PEG3470 MeO-dPEG™(4)-SH

alpha-Methoxy-omega-mercapto tetra(ethylene glycol)

CAS-No. 52190-55-3

Formula C9 H20 O4 S Mol. weight 224,32 g/mol

PEG2470 Ac-S-OEG-OH

S-Acetyl-mercapto-octa(ethylene glycol)

CAS-No. 223611-42-5

Formula C18 H36 O 9 S

PEG1167

MeO-PEG(7)-SH

alpha-Methoxy-omega-mercapto hepta(ethylene glycol)

CAS-No. 651042-82-9

Formula C15H32O 7S

Mol. weight 356,48 g/mol

PEG1195

MeO-PEG(7)-SS-PEG(7)-OMe

Methoxy-hepta(ethylen glycol)-disulfid

PEG5310

HO-PEG(8)-SH

alpha-Hydroxy-omega-mercapto octa(ethylene glycol)

PEG3480

MeO-dPEG™(8)-SH

alpha-Methoxy-omega-mercapto octa(ethylene glycol)

CAS-No. 651042-83-0

Formula

PEG2010

HS-FA-PEG(8)-OH

alpha-(11-Mercapto-undecanoylamido)-omega-hydroxy octa(ethylene glycol)

PEG3790

Ac-S-dPEG™(12)-OH

alpha-Acethylthio-omega-hydroxy dodeca(ethylene glycol)

CAS-No. 165729-83-9

Formula C 26 H 52O 13 S

PEGylation

PEG3490

MeO-dPEG™(12)-SH

alpha-Methoxy-omega-mercapto dodeca(ethylene glycol) MeO O SH 11

CAS-No. 134874-49-0

Formula C 25H 52O 12 S

Mol. weight 576,74 g/mol

PEG5460

HO-PEG-SH (5 kDa)

alpha-Hydroxy-omega-mercapto poly(ethylene glycol)

Formula HO-CH2 -CH2 -PEG-CH2 -CH2 -SH

Mol. weight 5000 Da

HO O SH n

PEG5470

HO-PEG-SH (3 kDa)

alpha-Hydroxy-omega-mercapto poly(ethylene glycol)

Formula HO-CH2 -CH2 -PEG-CH2 -CH2 -SH

Mol. weight 3000 Da

HO O SH n

PEG5450

HO-PEG-SH (10 kDa)

alpha-Hydroxy-omega-mercapto poly(ethylene glycol)

Formula HO-CH2 -CH2 -PEG-CH2 -CH2 -SH

Mol. weight 10000 Da

HO O SH n

PEG1018

HO-PEG-NH-CO-CH2CH2 -SH (3 kDa)

alpha-Hydroxy-omega-(3-mercaptopropionyl)-poly(ethylene glycol)

Mol. weight 3000 Da

HO O N H n

O SH

PEG1019

HO-PEG-NH-CO-CH2CH2 -SH (5 kDa)

alpha-Hydroxy-omega-(3-mercaptopropionyl)-poly(ethylene glycol)

Mol. weight 5000 Da

HO O N H n

O SH

PEG1017 HO-PEG-NH-CO-CH2CH2 -SH (10 kDa)

alpha-Hydroxy-omega-(3-mercaptopropionyl)-poly(ethylene glycol)

Mol. weight 10000 Da

PEG1024 HO-PEG-STrt (3 kDa)

alpha-Hydroxy-omega-tritylthio poly(ethylene glycol)

Mol. weight 3000 Da

PEG1025 HO-PEG-STrt (5 kDa)

alpha-Hydroxy-omega-tritylthio poly(ethylene glycol)

Mol. weight 5000 Da

PEG1023 HO-PEG-STrt (10 kDa)

alpha-Hydroxy-omega-tritylthio poly(ethylene glycol)

Mol. weight 10000 Da

PEG1172 MeO-PEG-SH (750 Da)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 750 Da

PEG1169 MeO-PEG-SH (2 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 2000 Da

PEG1171 MeO-PEG-SH (5 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 5000 Da

MeO

PEG1168

MeO-PEG-SH (10 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol) MeO

Mol. weight 10000 Da

PEG1170 MeO-PEG-SH (20 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol) MeO

Mol. weight 20000 Da

PEG4745 MeO-PEG-OPSS (750 Da)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol) MeO

Mol. weight 750 Da

PEG4750

MeO-PEG-OPSS (2 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 2000 Da

PEG4755 MeO-PEG-OPSS (5 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 5000 Da

PEG4760 MeO-PEG-OPSS (10 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 10000 Da

PEG4765

MeO-PEG-OPSS (20 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 20000 Da

7.4. Bismercapto-PEG Reagents

PEG1122 HS-PEG-SH (2 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol)

Mol. weight 2000 Da

PEG1124 HS-PEG-SH (3 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol)

Mol. weight 3000 Da

PEG1125 HS-PEG-SH (6 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol)

Mol. weight 6000 Da

PEG1121 HS-PEG-SH (10 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol)

Mol. weight 10000 Da

HS O O SH n

PEG1123 HS-PEG-SH (20 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol)

Mol. weight 20000 Da

HS O O SH

PEG4715 OPSS-PEG-OPSS (2 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

Mol. weight 2000 Da

PEG4725 OPSS-PEG-OPSS (3 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

Mol. weight 3000 Da

PEG4730 OPSS-PEG-OPSS (6 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

Mol. weight 6000 Da

PEG4735 OPSS-PEG-OPSS (10 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

Mol. weight 10000 Da

PEG4740

OPSS-PEG-OPSS (20 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

Mol. weight 20000 Da

7.5. Lipoamide-PEG Reagents

PEG3500

Lipoamide-dPEG™(4)-COOH

alpha-Lipoamide-omega-(propionic acid) tetra(ethylene glycol)

PEG7480

Lipoamide-dPEG™(4)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) tetra(ethylene glycol)

PEG3510

Lipoamide-dPEG™(8)-COOH

alpha-Lipomide-omega-(propionic acid) octa(ethylene glycol)

CAS-No. 1334172-70-1 Formula

PEG7490

Lipoamide-dPEG™(8)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) octa(ethylene glycol)

PEG3520

Lipoamide-dPEG™(12)-COOH

alpha-Lipoamide-omega-(propionic acid) dodeca(ethylene glycol)

CAS-No. 1334172-71-2

Formula C 35H 67NO 15 S

PEG7500

Lipoamide-dPEG™(12)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) dodeca(ethylene glycol)

PEG3540

Lipoamide-dPEG™(24)-COOH

alpha-Lipoamide-omega-(propionic acid) 24(ethylene glycol)

CAS-No. 1334172-71-2

Formula C 59 H115NO 27S 2 Mol. weight 1334,66 g/mol

PEG7510

Lipoamide-dPEG™(24)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) 24(ethylene glycol)

PEG7520

Lipoamide-dPEG™(36)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) 36(ethylene glycol)

PEG3570

Lipoamide-dPEG™(3)-biotin

alpha-Lipoamide-omega-biotinyl tri(ethylene glycol)

CAS-No. 1334172-74-5

Formula C 28 H 50 N4O 6 S 3

PEG3580

Lipoamide-dPEG™(11)-biotin

alpha-Lipoamide-omega-biotinyl undeca(ethylene glycol)

CAS-No. 960069-81-2 Formula

PEG7530

Lipoamide-dPEG™(23)-biotin

alpha-Lipoamide-omega-biotinyl 23(ethylene glycol)

PEG3550

Lipoamide-dPEG™(3)-mal

alpha-Lipoamide-omega-maleimido tri(ethylene glycol)

PEG3560

Lipoamide-dPEG™(11)-mal

alpha-Lipoamide-omega-maleimido undeca(ethylene glycol)

PEG3590

Lipoamide-dPEG™(4)-OMe

alpha-Lipoamide-omega-methoxy tetra(ethylene glycol)

CAS-No. 1334172-66-5

Formula C17H33 NO 5 S 2

PEG3600

Lipoamide-dPEG™(8)-OMe

alpha-Lipoamide-omega-methoxy octa(ethylene glycol)

CAS-No. 1334172-67-6

Formula

back to content arrow-up

PEGylation

PEG3610

Lipoamide-dPEG™(12)-OMe

alpha-Lipoamide-omega-methoxy dodeca(ethylene glycol)

CAS-No. 1334172-68-7

Formula C 33 H 65NO

Mol. weight 748 g/mol

PEG3620

Lipoamide-dPEG™(24)-OMe

alpha-Lipoamide-omega-methoxy 20(ethylene glycol)

CAS-No. 1334172-68-7

Formula C 57H113 NO 25 S 2 Mol. weight 1276,63 g/mol

7.6. Maleimido-PEG-Acids & -Esters

PEG2135 mal-COOH

3-(Maleimido-1-yl)propanoic acid

CAS-No. 7423-55-4

Formula C 7H7NO4

Mol. weight 169,13 g/mol

Product details

Product details

PEG4870 Mal-O2Oc-OH

{2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy] ethoxy}acetic acid

CAS-No. 173323-23-4

Formula C10 H13 NO 6

Mol. weight 243,21 g/mol

PEG1555 mal-PEG(2)-COOH

3-(2-(2-(3-Maleimidopropanamido)ethoxy)ethoxy) propanoic acid

CAS-No. 756525-98-1

Formula C14H20 N2O 7

Mol. weight 328,32 g/mol

PEG1560 mal-PEG(2)-NHS

3-(2-(2-(3-Maleimidopropanamido)ethoxy)ethoxy) propanoic acid succinimidyl ester

CAS-No. 955094-26-5

Formula C18 H23 N3 O 9

Mol. weight 425,39 g/mol

PEG7540 mal-PEG(2)-TFP

3-(2-(2-(3-Maleinimidopropanamido)ethoxy)ethoxy) propanoic acid 2,3,5,6-tetrafluorophenyl ester

Formula C 20 H20 F4N2O 7 Mol. weight 476,38 g/mol

PEG1570 mal-dPEG(4)-COOH

1-Maleimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid

CAS-No. 1263045-16-4

Formula C18 H28 N2O 9

Mol. weight 416,42 g/mol

PEG1575 mal-dPEG(4)-NHS

15-[(3-Maleimid-1-yl)propanoylamido]-4,7,10,13-tetraoxa-pentadecanoyl succinimidyl ester

CAS-No. 756525-99-2

Formula C 22H31N3 O 11 Mol. weight 513,5 g/mol

PEG7550 mal-dPEG™(4)-TFP

1-Maleinimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid 2,3,5,6-tetrafluorophenyl ester

PEG5110 Mal-L-Lys(Mal)-dPEG™(4)-COOH

15-(N-alpha,N-epsilon-Bis(3-(maleimido)propionyl)-L-lysinyl-amino)-4,7,10,13-tetraoxa-pentadecanoic acid

PEG5120 Mal-L-Lys(Mal)-dPEG™(4)-TFP

2,3,5,6-Tetrafluorophenyl 15-(N-alpha,N-epsilon-bis(3-(maleimido)propionyl)-L-lysinyl-amino)-4,7,10,13-tetraoxa-pentadecanoate

PEG3850 mal-dPEG™(6)-COOH

alpha-Maleimido-hexa(ethylene glycol)-omega-propionic acid

CAS-No. 1334177-79-5

PEG1585 mal-dPEG(6)-NHS

25-Maleimido-23-oxo-4,7,10,13,16,19-hexaoxa-22-azapentacosanoic acid succinimidyl ester

CAS-No. 1137109-21-7

Formula C

H

PEG1615 mal-dPEG(8)-COOH

1-Maleimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid

CAS-No. 1334177-86-4

Formula C 26 H44N2O 13 Mol. weight 592,63 g/mol

PEG1590 mal-dPEG(8)-NHS

1-Maleimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid succinimidyl ester

CAS-No. 756525-93-6

Formula C 30 H47N3 O 15

Mol. weight 689,71 g/mol

PEG7560 mal-dPEG™(8)-TFP

1-Maleinimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 2,3,5,6-tetrafluorophenyl ester

Formula C 32H44F4N2O 13

PEG2125 mal-PEG(12)-COOH

alpha-(3-(Maleinimido-1-yl)propanamido)-omega-(propionic acid)-dodecae(ethylene glycol)

CAS-No. 871133-36-7

Formula

PEG1550 mal-dPEG(12)-NHS

1-Maleimido-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oic acid succinimidyl ester

CAS-No. 326003-46-7

PEG7570 mal-dPEG™(12)-TFP

alpha-Maleinimido-omega-(2,3,5,6-tetrafluorophenyl propionate) dodeca(ethylen glycol)

PEG1600 mal-dPEG(24)-COOH

alpha-Maleimido-24(ethylene glycol)-omega-propionic acid

CAS-No. 871133-36-7 Formula C 58 H108 N2O

PEG1565 mal-dPEG(24)-NHS

alpha-Maleimido-24(ethylene glycol)-omega-propionic acid succinimidyl ester

CAS-No. 326003-46-7

Formula C 62H111N3 O 31

1394,55

PEG7580 mal-dPEG™(24)-TFP

alpha-Maleinimido-24(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG1209 mal-PEG(27)-NHS

alpha-Maleimido-omega-carboxy succinimidyl ester 27(ethylene glycol)

PEG7590 mal-dPEG™(36)-TFP

alpha-Maleinimido-36(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG7600 mal-dPEG™(24)-dPEG™(24)-TFP

alpha-Maleinimido-bis[24(ethylen glycol)]-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

PEG1059 mal-PEG-COOH (3 kDa)

alpha-Maleimido-omega-carboxy poly(ethylene glycol)

3000 Da

PEG1060 mal-PEG-COOH (5 kDa)

alpha-Maleimido-omega-carboxy poly(ethylene glycol)

PEG1058 mal-PEG-COOH (10 kDa)

alpha-Maleimido-omega-carboxy poly(ethylene glycol)

PEG1062 mal-PEG-NHS (3 kDa)

alpha-Maleimido-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG1063 mal-PEG-NHS (5 kDa)

alpha-Maleimido-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG1061 mal-PEG-NHS (10 kDa)

alpha-Maleimido-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6930 DOTA-PEG(11)-MAL*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-undeca(ethylene glycol)-omega-maleimido bistrifluoroacetate

CAS-No. 1325728-37-7

PEG6910

DOTA(t Bu3)-PEG(11)-MAL

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-undeca(ethylene glycol)-omega-maleimido

PEG6940

DOTA-PEG(23)-MAL*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-23(ethylene glycol)-omega-maleimido bistrifluoroacetate

PEG6920

DOTA(t Bu3)-PEG(23)-MAL

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-23(ethylene glycol)-omega-maleimido

7.7. Methoxy-PEG-Maleimides

PEG2375

MeO-PEG(4)-mal

alpha-Methoxy-omega-maleimido tetra(ethylene glycol)

CAS-No. 1263044-81-0

PEG2380

MeO-PEG(8)-mal

alpha-Methoxy-omega-maleimido octa(ethylene glycol)

CAS-No. 1334169-90-2

PEG1665

MeO-dPEG(12)-mal

Maleimidyl-N-(2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-yl)propanamide

CAS-No. 88504-24-9

PEG1675

MeO-dPEG(24)-mal

alpha-Methoxy-omega-maleimidyl-propanamide 24(ethylene glycol)

CAS-No. 88504-24-9

Formula C 56 H106 N2O 27 Mol.

PEG7350

Mal-PEG(4)-Lys(Fluorescein)-NH-PEG(24)-OMe N-alpha-(maleinimido-tetra(ethylene glycol))-epsilon-(5(6)-carboxyfluorescein)-L-lysine alpha-(mPEG(24)) ester

PEG3360

MeO-dPEG™(36)-mal

alpha-Methoxy-omega-maleimidyl-propanamide

36(ethylene glycol)

CAS-No. 88504-24-9

Formula

PEG3370

MeO-dPEG™(48)-mal

alpha-Methoxy-omega-maleimidyl-propanamide 48(ethylene glycol)

CAS-No. 88504-24-9

Formula C104H202N2O 51

PEG7360

Maleinimido-PEG(12)-[PEG(24)-propionic

CAS-No.

Formula

PEG7470 Mal-PEG(4)-[mPEG(12)] 3

Maleinimidyl-PEG(4)-[PEG(11)-OMe] 3

Formula C106 H202N 6 O

PEG3420 mal-PEG(4)-[PEG(24)-OMe] 3

Maleimido-PEG(4)-[PEG(24)-OMe] 3 ester

CAS-No. 1334178-05-0

Formula C178 H346 N 6 O 86

weight 3946,64 g/mol

PEG7300 Mal-PEG(4)-Lys-NH-PEG(24)-OMe*TFA

N-alpha-(maleinimido-tetra(ethylene glycol))-L-lysine alpha-(mPEG(24)) ester trifluoroacetate

Formula C 73 H139

PEG7290

Mal-PEG(4)-Lys(Boc)-NH-PEG(24)-OMe

N-alpha-(maleinimido-tetra(ethylene glycol))-epsilon-(t-butyloxycarbonyl)-L-lysine alpha-(mPEG(24)) ester

PEG7250 Mal-PEG(4)-Glu-PEG(24)-OMe

N-alpha-(maleinimido-tetra(ethylene glycol))-L-glutamic acid alpha-(mPEG(24)) ester

PEG7260 Mal-PEG(4)-Glu(TFP)-PEG(24)-OMe

N-alpha-(maleinimido-tetra(ethylene glycol))-gamma-(2,3,5,6-tetrafluorophenyl)-L-glutamic acid alpha-(mPEG(24)) ester

PEG7270

Mal-PEG(4)-Glu(TFP)-PEG(4)-Glu(TFP)-PEG(24)OMe N-maleinimido-bis[tetra(ethylene glycol))-gamma-(2,3,5,6-tetrafluorophenyl)-L-glutamyl]-(mPEG(24))

Formula C100

Mol. weight 2288,36 g/mol

PEG1150

MeO-PEG-mal (750 Da)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

Mol. weight 750 g/mol

PEG1147

MeO-PEG-mal (2 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

Mol. weight 2000 Da

PEG1149

MeO-PEG-mal (5 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

Mol. weight 5000 Da

PEG1146

MeO-PEG-mal (10 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

PEG1148

MeO-PEG-mal (20 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

Mol. weight 20000 Da

PEGylation

7.8. Bismaleimido-PEG Reagents

PEG1480 Mal-L-Lys(Mal)-hexylamine*TFA

N,N‘-(6-(6-aminohexylamino)-6-oxohexane-1,5-diyl) bis(3-maleinimido-propanamide)

CAS-No. 1301738-40-8

Formula C 26 H38 N 6 O 7 *CF 3 CO 2H

Mol. weight 546,62*114,02 g/mol

PEG1485 mal-dPEG(3)-mal

Bis-(1,13-(3-maleimidopropionyl)amido)-4,7,10-trioxatridecane

CAS-No. 756525-89-0

Formula C 24H34N

Mol. weight 522,55 g/mol

PEG2085 mal-PEG(11)-mal

alpha,omega-Bis-[(3-maleimid-1-yl)propanoylamido] undeca(ethylene glycol)

CAS-No. 854753-78-9

Formula C 38 H 62N4O 17

Mol. weight 846,92 g/mol

PEG1127 mal-PEG-mal (2 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

Mol. weight 2000 Da

PEG1129 mal-PEG-mal (3 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

Mol. weight 3000 Da

PEG1130 mal-PEG-mal (6 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

Mol. weight 6000 Da

PEG1126 mal-PEG-mal (10 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

PEG1128 mal-PEG-mal (20 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

PEG7670 Mal-PEG(12)-[PEG(11)-Mal] 3

Maleinimido-PEG(12)-[PEG(11)-amido-maleinimide]

PEG7400

Mal-L-Lys(Mal)-PEG(4)-PEG(12)-[PEG(24)-OMe] 3

Bis-Mal-Lysine-PEG(4)-PEG(12)-tris(mPEG(24))

PEG7410 Mal-L-Lys(Mal)-PEG(4)-PEG(12)-[PEG(24)-COOH]

PEGylation

. 8. PEG Reagents with Hydroxy-, Methoxyand other Functionalities

PEG7680

Bromoacetamido-PEG(12)-[PEG(11)-bromoacetamide] 3

Bromoacetamido-PEG(12)-tris[PEG(11)-bromoacetamide]

PEG1016

HO-PEG(8)-OH

Octa-ethylene glycol

CAS-No. 5117-19-1

Formula

PEG1015

HO-PEG(12)-OH

Dodeca-ethylene glycol

CAS-No. 25322-68-3 Formula

PEG1009 HO-PEG(28)-OH

alpha,omega-Bis-hydroxy 28(ethylene glycol)

CAS-No. 1053658-70-0

Formula C 56 H114O 29 Mol.

PEG1011 HO-PEG-OH (2 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 2000 Da

PEG1013 HO-PEG-OH (3 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 3000 Da

PEG1014 HO-PEG-OH (6 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 6000 Da

PEG1010 HO-PEG-OH (10 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 10000 Da

PEG1012 HO-PEG-OH (20 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 20000 Da

PEG1032 MeO-PEG(7)-OH

Hepta(ethylene glycol) methylether

CAS-No. 4437-01-8

Formula C15H32O 8

Mol. weight 340,41 g/mol

PEG1038 MeO-PEG(11)-OH

Undecae(ethylene glycol) methylether

CAS-No. 9004-74-4

Formula C 23 H48 O 12

Mol. weight 516,62

PEG3270 MeO-dPEG™(23)-OH

alpha-Methoxy-omega-hydroxy-23(ethylene glycol)

CAS-No. 9004-74-4

Formula C 47H96 O 24

Mol. weight 1045,25 g/mol

PEG3280

MeO-dPEG™(36)-OH

alpha-Methoxy-omega-hydroxy-36(ethylene glycol)

CAS-No. 9004-74-4

Formula C 73 H148 O 37

Mol. weight 1617,93 g/mol

PEG1037

MeO-PEG-OH (750 Da)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 750 Da

PEG1034

MeO-PEG-OH (2 kDa)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 2000 Da

PEG1036

MeO-PEG-OH (5 kDa)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 5000 Da

PEG1033 MeO-PEG-OH (10 kDa)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 10000 Da

PEG1035 MeO-PEG-OH (20 kDa)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol) MeO

CAS-No. 9004-74-4

Mol. weight 20000 Da

PEG1218

MeO-PEG-OMs (5 kDa)

alpha-Methoxy-omega-mesitylate poly(ethylene glycol)

Mol. weight 5000 Da

PEG5210 MeO-dPEG™(8)-DSPE (2R)-3-((hydroxy(26-oxo-2,5,8,11,14,17,20,23-octaoxa27-azanonacosan-29-yl)oxy)phosphoryl)oxy)propane-1,2-diyl distearate

Formula C 59 H116 NO 17P

Mol. weight 1142,52 g/mol

PEG0306 Palm3 -Cys-PEG-OH (3 kDa)

alpha-[(O,O‘-N-Trispalmitoyl)-2-amino-5,6-dihydroxy-4-thiahexanoylamido]-omega-hydroxy poly(ethylene glycol)

Mol. weight 3000

PEG0506 Palm3 -Cys-PEG-OH (5 kDa)

alpha-[(O,O‘-N-Trispalmitoyl)-2-amino-5,6-dihydroxy-4-thiahexanoylamido]-omega-hydroxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1135 MeO-PEG-Br (750 Da)

alpha-Methoxy-omega-bromo poly(ethylene glycol) MeO

Mol. weight 750 Da

PEG1132 MeO-PEG-Br (2 kDa)

alpha-Methoxy-omega-bromo poly(ethylene glycol)

Mol. weight 2000 Da

MeO O Br n

PEG1134 MeO-PEG-Br (5 kDa)

Mol. weight 5000 Da

alpha-Methoxy-omega-bromo poly(ethylene glycol) MeO O Br n

PEG1131 MeO-PEG-Br (10 kDa)

alpha-Methoxy-omega-bromo poly(ethylene glycol)

Mol. weight 10000 Da

MeO O Br n

PEG1133 MeO-PEG-Br (20 kDa)

alpha-Methoxy-omega-bromo poly(ethylene glycol)

Mol. weight 20000 Da

MeO

PEG1145 MeO-PEG-CHO (750 Da)

alpha-Methoxy-omega-formyl poly(ethylene glycol)

Mol. weight 750 g/mol

PEG1142 MeO-PEG-CHO (2 kDa)

alpha-Methoxy-omega-formyl poly(ethylene glycol)

Mol. weight 2000 Da

PEG1144

MeO-PEG-CHO (5 kDa)

alpha-Methoxy-omega-formyl poly(ethylene glycol)

PEG1141

MeO-PEG-CHO (10 kDa)

alpha-Methoxy-omega-formyl poly(ethylene glycol)

PEG1143

MeO-PEG-CHO (20 kDa)

alpha-Methoxy-omega-formyl poly(ethylene glycol)

PEG1179

OHC-PEG-CHO (2 kDa)

alpha,omega-Bis-formyl poly(ethylene glycol)

PEG1181

OHC-PEG-CHO (3 kDa)

alpha,omega-Bis-formyl poly(ethylene glycol)

PEG1182

OHC-PEG-CHO (6 kDa)

alpha,omega-Bis-formyl poly(ethylene glycol)

PEGylation

PEG1178

OHC-PEG-CHO (10 kDa)

alpha,omega-Bis-formyl poly(ethylene glycol)

PEG1180

OHC-PEG-CHO (20 kDa)

alpha,omega-Bis-formyl poly(ethylene glycol)

PEG4790

MeO-PEG-Si(OMe)3 (2 kDa)

alpha-Methoxy-omega-trimethoxysilyl poly(ethylene glycol)

PEG4795

MeO-PEG-Si(OMe)3 (5 kDa)

alpha-Methoxy-omega-trimethoxysilyl poly(ethylene glycol)

PEG4800

MeO-PEG-Si(OMe)3 (10 kDa)

alpha-Methoxy-omega-trimethoxysilyl poly(ethylene glycol)

PEG4805

MeO-PEG-Si(OMe)3 (20 kDa)

alpha-Methoxy-omega-trimethoxysilyl poly(ethylene glycol)

PEG1076 Br-PEG-Br (2 kDa)

alpha,omega-Bis-bromo poly(ethylene glycol)

Mol. weight 2000 Da

PEG1078 Br-PEG-Br (3 kDa)

alpha,omega-Bis-bromo poly(ethylene glycol)

PEG1079 Br-PEG-Br (6 kDa)

alpha,omega-Bis-bromo poly(ethylene glycol)

PEG1075 Br-PEG-Br (10 kDa)

alpha,omega-Bis-bromo poly(ethylene glycol)

PEG1077 Br-PEG-Br (20 kDa)

alpha,omega-Bis-bromo poly(ethylene glycol)

RL-3980 Mal-PEG(4)-SNAP N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-1(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-3,6,9,12-tetraoxapentadecan-15-amide

CAS-No. 1151762-31-0

Formula C 31H40 N 8 O 9

Mol. weight 668,71 g/mol

RL-4000 OPSS-PEG(4)-SNAP

N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-1-(3-(pyridin-2-yldisulfaneyl)propanamido)-3,6,9,12-tetraoxapentadecan-15-amide

CAS-No. 2278175-10-1

Formula C 32H42N 8 O 7S 2

Mol. weight 714,86 g/mol

RL-3680 Halo-PEG(2)-NH2*HCl

12-Chloro-3,6-dioxa-dodecan-1-amine hydrochloride H2N

CAS-No. 1035373-85-3

Formula C10 H22ClNO 2*HCl

Mol. weight 223,74*36,46 g/mol

RL-3690 Halo-PEG(4)-NH2*HCl

18-Chloro-3,6,9,12-tetraoxa-octadecan-1-amine hydrochloride

CAS-No. 1261238-20-3

Formula C14H30 ClNO4*HCl

Mol. weight 311,85*36,46 g/mol

RL-3470 Fmoc-AEEP-DMB

(9-Fluorenylmethyloxycarbonyl)amino-PEG(2)-Dtpp

PEG8150 Fmoc-PEG(4)-Dde

1-(9H-Fluorenylmethyloxycarbonylamino)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12-tetraoxapentadecyl-15-ol

CAS-No. 2093409-87-9

Formula C 34H43 NO 9 Mol. weight 609,71 g/mol

PEG7640 Formyl-PEG(12)-mal alpha-(4-formyl-benzamido)-omega-(ethylenediamino-maleinimido)-dodeca(ethylene glycol)

Formula C

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PEG5220 Mal-dPEG™(12)-DSPE (2R)-3-((((46-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)4,44-dioxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa3,43-diazahexatetracontyl)oxy)(hydroxy)phosphoryl) oxy)propane-1,2-diyldistearate

Formula C 75H140 N3 O 24P Mol. weight 1498,89 g/mol

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PEGylation

. 9. PEG-Containing Copolymers

PGA1125 N3 -PGA(20)

Azido-ethyltri(ethylene glycol)-poly(L-glutamic acid)

PGA1130 N3 -PGA(50)

Azido-ethyltri(ethylene glycol)-poly(L-glutamic acid)

PGA1135 N3 -PGA(100)

Azido-ethyltri(ethylene glycol)-poly(L-glutamic acid)

PGA1290 n Bu-PGA(20)[PEG2-N3 (10% mod)]

n-Butyl-poly(L-glutamic acid gamma-azido-ethyltri(ethylene glycol) amide) sodium salt (1020mol% azido substitution)

PGA1295 n Bu-PGA(50)[PEG2-N3 (10% mod)]

n-Butyl-poly(L-glutamic acid gamma-azido-ethyltri(ethylene glycol) amide) sodium salt (1020mol% azido substitution)

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PGA1300 n Bu-PGA(100)[PEG2-N3 (10% mod)]

n-Butyl-poly(L-glutamic acid gamma-azido-ethyltri(ethylene glycol) amide) sodium salt (1020mol% azido substitution)

Mol. weight 18300 Da

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PEGylation

Notes

PEGylation Code of Conduct

As business activity of Iris Biotech GmbH impacts people’s lives and health, it must be operated in ethical and correct manner and act with integrity and responsibility. To ensure high ethical standards and fair business practices, Iris Biotech GmbH applies an integrated policy known as its Code of Conduct.

In 2001 Iris Biotech GmbH was founded just at the beginning of the Biotech movement and the first remarkable breakthrough of biotech pharma products. Although the biotech field is rather young compared to other industries we believe on long-term business, a good partnership between our business partners and Iris Biotech GmbH and a good reputation. It is our duty as well as our responsibility to maintain and to extend this over the next generations – based on the principles of an honourable and prudent tradesman which based upon the concept of honourable entrepreneurship.

This Code of Conduct has been developed following the “Voluntary Guidelines for Manufacturers of Fine Chemical Intermediates and Active Ingredients” issued by AIME (Agrochemical & Intermediates Manufacturers in Europe) and the requirements of some of our business associates.

Iris Biotech GmbH commits to hold this Code of Conduct and to include and apply its principles in the management system and the company policies.

Ethics

Iris Biotech GmbH undertakes business in an ethical manner and acts with integrity. All corruption, extortion and embezzlement are prohibited. We do not pay or accept bribes or participate in other illegal inducements in business or government relationships. We conduct our business in compliance with all applicable anti-trust laws. Employees are encouraged to report concerns or illegal activities in the workplace, without threat of reprisal, intimidation or harassment.

Labour

Iris Biotech GmbH is committed to uphold the human rights of workers and to treat them with dignity and respect. Child labour, workplace harassment, discrimination, and harsh and inhumane treatment are prohibited. Iris Biotech GmbH respects the rights of the employees to associate freely, join or not join labour unions, seek representation and join workers’ councils. Employees are paid and their working timetable is established according to applicable wage and labour laws. Employees are able to communicate openly with management regarding working conditions without threat of reprisal, intimidation or harassment.

General Policies

Contracts and Secrecy Agreements are binding and the confidential information received is only used for intended purposes. Clear management and organizational structures exist to provide efficient normal working and to address problems quickly. Know-how is protected and intellectual property isrespected.

Health and Safety

Iris Biotech GmbH provides a safe and healthy working environment to the employees and protects them from overexposure to chemical and physical hazards. Products are produced, stored and shipped under the guidelines of the relevant chemical and safety legislation. Risks and emergency scenarios are identified and evaluated, and their possible impact is minimized by implementing emergency plans and written procedures. Safety information regarding hazardous materials is available to educate, train and protect workers from hazards. Preventive equipment and facilities maintenance is performed at suitable periods to reduce potential hazards. Employees are regularly trained in health and safety matters and are informed about product properties and risk classification when it is required.

Environment

Iris Biotech GmbH operates in an environmentally responsible and efficient manner, minimizing adverse impacts on the environment. Waste streams are managed to ensure a safe handling, movement, storage, recycling and reuse, before and after being generated. Systems to prevent and mitigate accidental spills and releases to the environment are in place. All required environmental permits and licenses are obtained and their operational and reporting requirements are complied with.

Production and Quality Management

A quality management system following the Good Distribution Practices (GDP rules) of Active Pharmaceutical Ingredients is established covering all the aspects of the worldwide distribution of products. Regular audits are performed to evaluate the efficiency and fulfilling of the quality system. Process controls to provide reproducible product quality are established. There are preventive maintenance procedures to ensure plant reliability and the lowest risk of failure. Staff is trained periodically about GMP and GDP rules. Procedures are established and installations are designed to avoid cross contamination. Batch and analytical records are kept for inspection and audit purposes for suitable periods according guidelines.

Research and Development

Research and development staff education is appropriate to their functional activity and they are trained to develop, optimize and scale-up the processes. Intellectual property is respected and knowhow protected. Development of manufacturing processes reflects the principles of the Green Chemistry according to the American Chemical Society Green Chemistry Institute. Animal testing is not used unless alternatives are not scientifically valid or accepted by regulators. If animal testing is carried out, animals are treated so that pain and stress are minimized.

PEGylation Terms and Conditions of Sales

All orders placed by a buyer are accepted and all contracts are made subject to the terms which shall prevail and be effective notwithstanding any variations or additions contained in any order or other document submitted by the buyer. No modification of these terms shall be binding upon Iris Biotech GmbH unless made in writing by an authorised representative of Iris Biotech GmbH.

Placing of Orders

Every order made by the buyer shall be deemed an offer by the buyer to purchase products from Iris Biotech GmbH and will not be binding on Iris Biotech GmbH until a duly authorised representative of Iris Biotech GmbH has accepted the offer made by the buyer. Iris Biotech GmbH may accept orders from commercial, educational or government organisations, but not from private individuals and Iris Biotech GmbH reserves the right to insist on a written order and/or references from the buyer before proceeding.

There is no minimum order value. At the time of acceptance of an order Iris Biotech GmbH will either arrange prompt despatch from stock or the manufacture/acquisition of material to satisfy the order. In the event of the latter Iris Biotech GmbH will indicate an estimated delivery date. In addition to all its other rights Iris Biotech GmbH reserves the right to refuse the subsequent cancellation of the order if Iris Biotech GmbH expects to deliver theproduct on or prior to the estimated delivery date. Time shall not be of the essence in respect of delivery of the products. If Iris Biotech GmbH is unable to deliver any products by reason of any circumstances beyond its reasonable control („Force Majeure“) then the period for delivery shall be extended by the time lost due to such Force Majeure. Details of Force Majeure will be forwarded by Iris Biotech GmbH to the buyer as soon as reasonably practicable.

Prices, Quotations and Payments

Prices are subject to change. For the avoidance of doubt, the price advised by Iris Biotech GmbH at the time of the buyer placing the order shall supersede any previous price indications. The buyer must contact the local office of Iris Biotech GmbH before ordering if further information is required. Unless otherwise agreed by the buyer and Iris Biotech GmbH, the price shall be for delivery ex-works. In the event that the buyer requires delivery of the products otherwise than ex-works the buyer should contact the local office of Iris Biotech GmbH in order to detail its requirements. Iris Biotech GmbH shall, at its discretion, arrange the buyer‘s delivery requirements including, without limitation, transit insurance, the mode of transit (Iris Biotech GmbH reserves the right to vary the mode of transit if any regulations or other relevant considerations so require) and any special packaging requirements (including cylinders). For the avoidance of doubt all costs of delivery and packaging in accordance with the buyer‘s requests over and above that of delivery in standard packaging ex-works shall be for the buyer‘s account unless otherwise agreed by both parties. Incoterms 2020 shall apply. Any tax, duty or charge imposed by governmental authority or otherwise and any other applicable taxes, duties or charges shall be for the buyer‘s account. Iris Biotech GmbH may, on request and where possible, provide quotations for multiple packs or bulk quantities, and non-listed items. Irrespective of the type of request or means of response all quotations must be accepted by the buyer without condition and in writing before an order will be accepted by Iris Biotech GmbH. Unless agreed in writing on different terms, quotations are valid for 30 days from the date thereof. Payment terms are net 30 days from invoice date unless otherwise agreed in writing. Iris Biotech GmbH reserves the right to request advance payment at its discretion. For overseas transactions the buyer shall pay all the banking charges of Iris Biotech GmbH. The buyer shall not be entitled to withhold or set-off payment for the products for any reason whatsoever. Government/

Corporate Visa and MasterCard (and other such credit cards) may be accepted on approved accounts for payment of the products. Personal credit cards are not acceptable. Failure to comply with the terms of payment of Iris Biotech GmbH shall constitute default without reminder. In these circumstances Iris Biotech GmbH may (without prejudice to any other of its rights under these terms) charge interest to accrue on a daily basis at the rate of 2% per month from the date upon which payment falls due to the actual date of payment (such interest shall be paid monthly). If the buyer shall fail to fulfil the payment terms in respect of any invoice of Iris Biotech GmbH Iris Biotech GmbH may demand payment of all outstanding balances from the buyer whether due or not and/or cancel all outstanding orders and/or decline to make further deliveries or provision of services except upon receipt of cash or satisfactory securities. Until payment by the buyer in full of the price and any other monies due to Iris Biotech GmbH in respect of all other products or services supplied or agreed to be supplied by Iris Biotech GmbH to the buyer (including but without limitation any costs of delivery) the property in the products shall remain vested in Iris Biotech GmbH.

Shipping, Packaging and Returns

The buyer shall inspect goods immediately on receipt and inform Iris Biotech GmbH of any shortage or damage within five days. Quality problems must be notified within ten days of receipt. Goods must not be returned without prior written authorisation of Iris Biotech GmbH. Iris Biotech GmbH shall at its sole discretion replace the defective products (or parts thereof) free of charge or refund the price (or proportionate price) to buyer. Opened or damaged containers cannot be returned by the buyer without the written prior agreement of Iris Biotech GmbH. In the case of agreed damaged containers which cannot be so returned, the buyer assumes responsibility for the safe disposal of such containers in accordance with all applicable laws.

Product Quality, Specifications and Technical Information

Products are analysed in the Quality Control laboratories of Iris Biotech GmbH’s production partners by methods and procedures which Iris Biotech GmbH considers appropriate. In the event of any dispute concerning reported discrepancies arising from the buyer’s analytical results, determined by the buyer’s own analytical procedures, Iris Biotech GmbH reserves the right to rely on the results of own analytical methods of Iris Biotech GmbH. Certificates of Analysis or Certificates of Conformity are available at the discretion of Iris Biotech GmbH for bulk orders but not normally for prepack orders. Iris Biotech GmbH reserves the right to make a charge for such certification. Specifications may change and reasonable variation from any value listed should not form the basis of a dispute. Any supply by Iris Biotech GmbH of bespoke or custom product for a buyer shall be to a specification agreed by both parties in writing. Technical information, provided orally, in writing, or by electronic means by or on behalf of Iris Biotech GmbH, including any descriptions, references, illustrations or diagrams in any catalogue or brochure, is provided for guidance purposes only and is subject to change.

Safety

All chemicals should be handled only by competent, suitably trained persons, familiar with laboratory procedures and potential chemical hazards. The burden of safe use of the products of Iris Biotech GmbH vests in the buyer. The buyer assumes all responsibility for warning his employees, and any persons who might reasonably be expected to come into contact with the products, of all risks to person and property in any way connected with the products and for instructing them in their safe handling and use. The buyer also assumes the responsibility for the safe disposal of all products in accordance with all applicable laws.

PEGylation

Uses, Warranties and Liabilities

All products of Iris Biotech GmbH are intended for laboratory research purposes and unless otherwise stated on product labels, in the catalogue and product information sheet of Iris Biotech GmbH or in other literature furnished to the buyer, are not to be used for any other purposes, including but not limited to use as or as components in drugs for human or animal use, medical devices, cosmetics, food additives, household chemicals, agricultural or horticultural products or pesticides. Iris Biotech GmbH offers no warranty regarding the fitness of any product for a particular purpose and shall not be responsible for any loss or damage whatsoever arising there from. No warranty or representation is given by Iris Biotech GmbH that the products do not infringe any letters patent, trademarks, registered designs or other industrial rights. The buyer further warrants to Iris Biotech GmbH that any use of the products in the United States of America shall not result in the products becoming adulterated or misbranded within the meaning of the Federal Food, Drug and Cosmetic Act (or such equivalent legislation in force in the buyer‘s jurisdiction) and shall not be materials which may not, under sections 404, 505 or 512 of the Act, be introduced into interstate commerce. The buyer acknowledges that, since the products of Iris Biotech GmbH are intended for research purposes, they may not be on the Toxic Substances Control Act 1976 („TSCA“) inventory. The buyer warrants that it shall ensure that the products are approved for use under the TSCA (or such other equivalent legislation in force in the buyer‘s jurisdiction), if applicable. The buyer shall be responsible for complying with any legislation or regulations governing the use of the products and their importation into the country of destination (for the avoidance of doubt to include, without limitation, the TSCA and all its amendments, all EINECS, ELINCS and NONS regulations). If any licence or consent of any government or other authority shall be required for the acquisition, carriage or use of the products by the buyer the buyer shall obtain the same at its own expense and if necessary produce evidence of the same to Iris Biotech GmbH on demand. Failure to do so shall not entitle the buyer to withhold or delay payment. Any additional expenses or charges incurred by Iris Biotech GmbH resulting from such failure shall be for the buyer‘s account. Save for death or personal injury caused by negligence of Iris Biotech GmbH, sole obligation of Iris Biotech GmbH and buyer‘s exclusive remedy with respect to the products proved to the satisfaction of Iris Biotech GmbH to be defective or products incorrectly supplied shall be to accept the return of said products to Iris Biotech GmbH for refund of the actual purchase price paid by the buyer (or proportionate part thereof), or replacement of the defective product (or part thereof) with alternative product. Iris Biotech GmbH shall have no liability to the buyer under or arising directly or indirectly out of or otherwise in connection with the supply of products by Iris Biotech GmbH to the buyer and/or their re-sale or use by the buyer or for any product, process or services of the buyer which in any way comprises the product in contract tort (including negligence or breach of statutory duty) or otherwise for pure economic loss, loss of profit, business, reputation, depletion of brand, contracts, revenues or anticipated savings or for any special indirect or consequential damage or loss of any nature except as may otherwise be expressly provided for in these terms. All implied warranties, terms and representations in respect of the products (whether implied by statute or otherwise) are excluded to the fullest extent permitted by law. The buyer shall indemnify Iris Biotech GmbH for and against any and all losses, damages and expenses, including legal fees and other costs of defending any action, that Iris Biotech GmbH may sustain or incur as a result of any act or omission by the buyer, its officers, agents or employees, its successors or assignees, its customers or all other third parties, whether direct or indirect, in connection with the use of any product. For the avoidance of doubt and in the event that Iris Biotech GmbH supplies bespoke or custom product to the buyer‘s design or specification, this indemnity shall extend to include any claim by a third party that the manufacture of the product for the buyer or the use of the product by the buyer infringes the intellectual property rights of any third party.

General

Iris Biotech GmbH shall be entitled to assign or sub-contract all or any of its rights and obligations hereunder. The buyer shall not be entitled to assign, transfer, sub-contract or otherwise delegate any of its rights or obligations hereunder. Any delay or forbearance by Iris Biotech GmbH in exercising any right or remedy under these terms shall not constitute a waiver of such right or remedy. If any provision of these terms is held by any competent authority to be invalid or unenforceable in whole or in part the validity of the other provisions of these terms and the remainder of the provision in question shall not be affected. These terms shall be governed by German Law and the German Courts shall have exclusive jurisdiction for the hearing of any dispute between the parties save in relation to enforcement where the jurisdiction of the German Courts shall be non-exclusive.

Notes

PEGylation Index

PEGylation

PEGylation

PEGylation

Get in Contact

Iris Biotech GmbH

Adalbert-Zoellner-Str. 1 95615 Marktredwitz Germany

+49 (0) 9231 97121-0 +49 (0) 9231 97121-99 info@iris-biotech.de www.iris-biotech.de

Distribution Partners

The list contains the current distributors of Iris Biotech in different regions of the world. The latest list of distribution partners and contact details is available at: www.iris-biotech.de/distribution-partner

China:

Chengdu Yoo Technology Co., Ltd.

Japan:

BizCom Japan, Inc.

Shigematsu & Co., Ltd

Cosmo Bio Co., Ltd.

USA & Canada: Peptide Solutions LLC

India, Bangladesh, Oman, Sri Lanka, United Arab Emirates: Sumit Biosciences Pvt Ltd.

Singapore, Thailand, Malaysia, Indonesia, Vietnam, Philippines, Brunei, Burma (Myanmar), Laos, Cambodia, Timor-Leste:

SciClix Pte. Ltd.

Empowering Peptide Innovation