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PEG

Empowering Peptide Innovation

With this guiding theme in mind, Iris Biotech’s mission is to support researchers by supplying

• innovative technologies,

• rare compounds,

• as well as a broad portfolio on standard consumables, available in flexible quantities from small scale to bulk quantities. To fulfill our dedication “Empowering Peptide Innovation”, we are attending various conferences, symposia, and exhibitions each year. This allows us to remain in direct contact with scientists all over the world, both from academia and industry, to exchange knowledge, and to gather new ideas to tackle your current challenges.

Guided by our dedication to provide

• competent service,

• as well as novel substances and latest technologies,

Iris Biotech is your trusted partner for the world of peptides, while having strong expertise in associated disciplines. Thus, our portfolio comprises reagents and tools for the synthesis and modification of peptides, e.g., amino acids, resins and solvents but also for related technologies such as drug delivery, linkerology® and life sciences.

Owed to the growing demand for tailor-made compounds, our portfolio is fine-tuned by our custom synthesis service at Iris Biotech Laboratories. Our skilled scientists offer profound expertise in de novo route development,

• upscaling towards larger scale production,

• as well as synthesis optimization for increased efficiency.

Examples are the synthesis of rare chiral building blocks, unnatural amino acid derivatives, sophisticated orthogonal protecting groups, heterocycles, building blocks for nucleotides, PEGs and PEG-analogs as well as specific linkers for controlled drug delivery and release.

Portfolio Overview

Peptide Synthesis and Modification

(Protected) Amino Acids

Standards such as Fmoc-D/L-AAA and Boc-D/L-AAA, Smoc amino acids for peptide synthesis in water, variety of protecting groups (e.g., Pbf, Trt, tBu, Bzl, Acm, Mob, SIT, Phacm, Allocam, Mmt), unusual amino acids, fluorinated derivatives, substituted prolines, arginine analogs

Building Blocks

Amino alcohols, amino aldehydes, diamines and hydrazines, (pseudoproline) dipeptides, polyamines and spermines, fatty acid derivatives, peptide nucleic acids (PNAs)

Reagents

Coupling reagents, solvents and scavengers, protecting groups

Resins

Preloaded resins (e.g., based on Trityl, TCP, TentaGel, Methoxybenzhydryl, Merrifield, PAM, Rink, Wang), scavenger resins, hydrazone resins, poly(acrylamide) resins, Cyclover

Linkerology® and Drug Delivery Life Sciences

Linkers for Solid Phase Peptide Synthesis

Cleavable Linkers

Val-Ala-based, Val-Cit-based, disulfide-based, Dde-helping hands, pH-sensitive linkers

Photo-Activatable Linkers

Functionalized Linkers

Clickable linkers, trifunctional linkers, linkers with maleimide function, cross-linkers, selective N-term acylation and biotinylation, 5HP2O

PROTACs

Ligands, linkers & modules

Fullerenes, Poly(2-oxazolines), Dextrans & Plant-Derived Cholesterol

Superparamagnetic Iron Oxide Nanoparticles

Poly-Amino Acids

Poly-Arg, Poly-Glu, Poly-Lys, Poly-Orn, Poly-Sar

PEGylation

Branched PEGylating reagents, (amino-)PEG-acids, PEG-amines & hydrazides & guanidines, reagents for Click-conjugation, Biotin-PEG-reagents, PEG-thiols, PEG-maleimides, other PEGylating reagents

Biotinylation Reagents

Carbohydrates

Galactose, Glucose, Mannose, Xylose and others

Drug Metabolites

Peptides

Substrates & Inhibitors

E.g., protein kinase inhibitors, substrates for fusion (Halo/ Snap/Clip)-tagged proteins

Natural Products

Dyes and Fluorescent Labels

E.g., ICG, AMC, DAPI

Maillard & Amadori Reaction Products

Large portfolio of derivatives useful as standards for food, pharma and cosmetics industry

Vitamins

Custom Synthesis

Your project requires a compound not listed in our portfolio? Get in contact and inquire about our custom synthesis capabilities.

Our experienced scientists are excited to accept your synthetic challenge! In such cases, your request undergoes the following stages:

Step-by-Step Analysis

Customer’s demands

Process Evaluation

Det ailed literature review

Synthetic possibilities

Strategy Development

Protocol development

Method development and validation

• Customized synthesis

Our Service Promise

Quality Consistency

• Identity confirmation Purity verification

All our services are based on high standards, transparency & documentation, trust, honesty & confidentiality, as well as the required know-how.

High Standards

Values: sustainability & responsibility

State-of-the-art equipment & latest technologies

High quality standards

Qualified suppliers & regular audits

Trust, Honesty & Confidentiality

Intergenerational business valuing partnerships

• Meeting the customer‘s expectations

• Integrity towards our customers

Transparency & Documentation

Talk to our specialists – customer care

Certificates of analysis & origin

Impurity profiling

Safety data sheets

• Analytical and process reports

Our Know-How

One-step reactions & complex multi-step synthesis

• Scalability from mg to kg quantities

• Route scouting

2.4.

7.1. (Protected)

7.2. (Protected) Mercapto-PEG-Amines

7.3. (Protected)

7.4. Bismercapto-PEG

7.5.

7.7. Methoxy-PEG-Maleimides

7.8. Bismaleimido-PEG

1. Poly(ethylene glycol) –the Pioneer in Polymer Therapeutics

1.1. Background

PEGylated proteins were the first polymer therapeutic drugs reaching market approval around 1990. PEGs show a spectrum of unique physical and chemical properties which have been described in literature extensively. Here are summarized the most common ones:

PEG fragments can be attached to many different positions in a protein. Amino groups of any solvent accessible lysines as well as the N-termini are the most prominent candidates for conjugation together with thiol functions of cysteines. The C-terminus or carboxylic groups from aspartic acid and glutamic acid are also possible for conjugation, however, are less frequently used.

• PEG can serve as spacer or cross linker between two moieties.

• PEG provides high solubility and does not contain charged side-chains. PEG is FDA-approved for internal application, is non-toxic, lacks T-cell epitopes, and shows no signs of immunogenicity in most animal experiments.

• PEG derivatives are available from uniform molecules with short chain lengths (down to two ethylene oxide units only), to long disperse constructs, allowing regio-specific chemical conjugation with small molecules, proteins, peptides, and biopharmaceuticals through their broad variety of available terminal chemical groups.

Summary of chemical and physical properties of PEGs:

Good solubility in BOTH hydrophilic AND hydrophobic solvents as water, toluene, methylene chloride, and many other organic solvents.

• Insoluble in diethyl ether, hexane, ethylene glycol.

• Insoluble in water at elevated temperature.

• The solubility is influenced by formed derivatives. Highly mobile in water with high exclusion volume; large hydrodynamic radius. Complex formation with metal cations is possible. Can be used to precipitate proteins and nucleic acids. Form two-phase systems with aqueous solutions of other polymers.

• Non-toxic and FDA-approved for use in drug products.

PEGylation of biopharmaceuticals or small molecules brings the following effects:

• Improves solubility of conjugated molecules. Renders proteins non-immunogenic and tolerogenic.

Reduces the rate of renal clearance through the kidney and alters pharmacokinetics. Alters electroosmotic flow. Increases cell permeability.

The increasing use of PEG and PEGylated products in pharmaceutical research and on the market provides new insights into the underlying mechanism of their properties. PEGs are e.g., not biodegradable in the human body, so it can lead to certain accumulation in cytoplasmic vacuoles, particularly at high doses and especially in kidneys:

Fig. 1: (Left) PEG immunoreactivity in kidney from rats given 100 mg/kg 10kPEG IV. There is variable but diffuse PEG staining in tubular epithelial cells throughout the renal cortex. PEG staining is not associated with epithelial cell vacuolation (magnification 230x).

(Right) Cytoplasmic vacuoles (arrows) are associated with variable levels of PEG immunoreactivity in the kidney (300x) in rats given 100 mg/kg 40kPEG. The cortical tubule and choroid plexus had both darkly stained and clear vacuoles. (pictures adapted from Rudman et al. 2013).

Despite all sporadic drawbacks as mentioned above, PEG, nevertheless, is still the most widely applied polymer in drug delivery.

This brochure displays a portfolio of a thousand different PEG derivatives with a length ranging from only 2 ethylene glycol units (with a molecular weight around 100 g/mol) up to long chain PEGs of molecular weights beyond 20,000 g/mol. Further to this standard portfolio, we can produce also customized PEG variants according to your personal needs.

References:

→ Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice; M. R. Battista, A. Grigoletto, T. Tedeschini, A. Cellucci, F. Colaceci, R. Laufer, G. Pasut, A. Di Marco; PLOS ONE 2022; 17: e0265749. arrow-up-right-from-square https://doi.org/10.1371/journal.pone.0265749

→ Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy; A. Dodd, A. A. Natfji, A. Evangelinos, A. Grigoletto, G. Pasut, F. Beards, L. Renshall, H. M. I. Osborn, F. Greco, L. K. Harris; Molecular pharmaceutics 2022; 19: 345-353. arrow-up-right-from-square https://doi.org/10.1021/acs.molpharmaceut.1c00498

→ Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines; J. Szebeni, G. Storm, J. Y. Ljubimova, M. Castells, E. J. Phillips, K. Turjeman, Y. Barenholz, D. J. A. Crommelin, M. A. Dobrovolskaia; Nature Nanotechnology 2022; 17: 337-346. arrow-up-right-from-square https://doi.org/10.1038/s41565-022-01071-x

→ The role and impact of polyethylene glycol on anaphylactic reactions to COVID-19 nano-vaccines; P. Bigini, M. Gobbi, M. Bonati, A. Clavenna, M. Zucchetti, S. Garattini, G. Pasut; Nature Nanotechnology 2021; 16: 1169-1171. arrow-up-right-from-square https://doi.org/10.1038/s41565-021-01001-3

→ Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines; S. M. Moghimi; Molecular Therapy 2021; 29: 898-900. arrow-up-right-from-square https://doi.org/10.1016/j.ymthe.2021.01.030

→ Polyethylene glycol-based linkers as hydrophilicity reservoir for antibody-drug conjugates; T. Tedeschini, B. Campara, A. Grigoletto, M. Bellini, M. Salvalaio, Y. Matsuno, A. Suzuki, H. Yoshioka, G. Pasut; Journal of Controlled Release 2021; 337: 431-447. arrow-up-right-from-square https://doi.org/10.1016/j.jconrel.2021.07.041

PEGylation

→ PEG hydration and conformation in aqueous solution: Hints to macromolecular crowding; S. Di Fonzo,B. Bellich, A. Gamini, N. Quadri, A. Cesàro; Polymer 2019; 175: 57-64. arrow-up-right-from-square https://doi.org/10.1016/j.polymer.2019.05.004

→ A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers; D. Huesmann, A. Sevenich, B. Weber, M. Barz; Polymer 2015; 67: 240-248. arrow-up-right-from-square https://doi.org/10.1016/j.polymer.2015.04.070

→ On the biodegradability of polyethylene glycol, polypeptoids and poly(2-oxazoline)s; J. Ulbricht, R. Jordan, R. Luxenhofer; Biomaterials 2014; 35: 4848-61. arrow-up-right-from-square https://doi.org/10.1016/j.biomaterials.2014.02.029

→ Bioconjugate Techniques (Third Edition); G. T. Hermanson; G. T. Hermanson 2013: 1146. arrow-up-right-from-square https://doi.org/10.1016/C2009-0-64240-9

→ Chapter 6 - Heterobifunctional Crosslinkers; G. T. Hermanson; Bioconjugate Techniques (Third Edition) G. T. Hermanson 2013: 299-339. arrow-up-right-from-square https://doi.org/10.1016/B978-0-12-382239-0.00006-6

→ High molecular weight polyethylene glycol cellular distribution and PEG-associated cytoplasmic vacuolation is molecular weight dependent and does not require conjugation to proteins; D. G. Rudmann, J. T. Alston, J. C. Hanson, S. Heidel; Toxicol Pathol 2013; 41: 970-83. arrow-up-right-from-square https://doi.org/10.1177/0192623312474726

→ Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications; S. S. Banerjee, N. Aher, R. Patil, J. Khandare; J Drug Deliv 2012; 103973. arrow-up-right-from-square https://doi.org/10.1155/2012/103973

→ Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics; M. Barz, R. Luxenhofer, R. Zentel, M. J. Vicent; Polymer Chemistry 2011; 2: 1900-1918. arrow-up-right-from-square https://doi.org/10.1039/c0py00406e

→ Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives; K. Knop, R. Hoogenboom, D. Fischer, U. S. Schubert; Angew Chem Int Ed Engl 2010; 49: 6288-308. arrow-up-right-from-square https://doi.org/10.1002/anie.200902672

→ Peptide and Protein PEGylation III: Advances in Chemistry and Clinical Applications; F. M. Veronese, J. M. Harris; Advanced Drug Delivery Reviews 2008; 60: 1-88.

→ PEGylation - The Magic Wand. Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters; T. Bruckdorfer; PharManufacturing 2007; 1: 34-41.

→ PEGylation, successful approach to drug delivery; F. M. Veronese, G. Pasut; Drug Discov Today 2005; 10: 1451-8. arrow-up-right-from-square https://doi.org/10.1016/S1359-6446(05)03575-0

→ PEGylated antibodies and antibody fragments for improved therapy: a review; A. P. Chapman; Adv Drug Deliv Rev 2002; 54: 531-45. arrow-up-right-from-square https://doi.org/10.1016/S0169-409X(02)00026-1

→ Chemistry for peptide and protein PEGylation; M. J. Roberts, M. D. Bentley, J. M. Harris; Adv Drug Deliv Rev 2002; 54: 459-76. arrow-up-right-from-square https://doi.org/10.1016/S0169-409X(02)00022-4

→ Peptide and protein PEGylation: a review of problems and solutions; F. M. Veronese; Biomaterials 2001; 22: 405-17. arrow-up-right-from-square https://doi.org/10.1016/S0142-9612(00)00193-9

→ Synthesis and characterization of poly(ethylene glycol) derivatives; J. M. Harris, E. C. Struck, M. G. Case, M. S. Paley, M. Yalpani, J. M. Van Alstine, D. E. Brooks; Journal of Polymer Science: Polymer Chemistry Edition 1984; 22: 341-352. arrow-up-right-from-square https://doi.org/10.1002/pol.1984.170220207

→ Functionalization of poly(ethylene glycol) and monomethoxy-poly(ethylene glycol); A. F. Bückmann, M. Morr, G. Johansson; Die Makromolekulare Chemie 1981; 182: 1379-1384. arrow-up-right-from-square https://doi.org/10.1002/macp.1981.021820509

1.2. Principles of Polymer Therapeutics and Drug Delivery Systems

Modern drug development technologies such as combinatorial chemistry and automated high-throughput screening have led to the identification of numerous potential new active pharmaceutical ingredients (APls). However, many of those promising new molecules never reach market approval because they are not sufficiently soluble, cannot reach the desired target, are attacked by the immune system, are degraded by endogenous enzymes, or suffer from rapid renal clearance. To overcome these restrictions, first attempts with polymers were made already in the 1960s - either by attaching the therapeutic agent covalently to a polymer or by entrapping it non-covalently in a polymer nanoparticle.

The first polymer-drug conjugates that showed promising results contained poly(ethylene glycol) “PEG”, and until today, PEG is the most widely used gold standard for stealth polymers in the continuously emerging field of polymer-based drug delivery. The pharmacological effects of PEG and many other first generation polymer attachments are mainly of physical nature:

Solubilizing

PEG and many other polymers are very hygroscopic and hydrophilic and thus improve the plasma solubility of hydrophobic pharmaceuticals. By this, higher therapeutic concentrations in plasma and tissues are accessible.

Preventing Degradation and Reducing lmmunogenicity

Polymer chains are covering the surface of a pharmaceutical, thus efficiently shielding it against attacks by the immune system or degrading enzymes such as proteases. The polymeric shield has characteristics rather like a solvent than like a protein. This prevents uptake by the macrophage system. Recognition by the immune system (antibodies, proteases, and other degradation enzymes etc.) is significantly reduced. The drug stays intact and is not destroyed (degraded or metabolized) during its presence in the body and journey through the physiological system.

Preventing Excretion

Hygroscopic polymers are surrounded by a large solvating sphere of water molecules. The hydrodynamic radius of the polymer-drug conjugate can be increased to a size larger than the diameter of the kidney’s glomerular capillaries (6 to 12 nm). Retarded renal filtration prolongs plasma half-life of the biological drug by means of a purely biophysical size effect, without any receptor interactions that may influence pharmacodynamics or lead to side effects.

Fig. 2: PEGylation increases the hydrodynamic radius and aqueous solubility of proteins. Hence, the pharmacokinetic properties of a PEGylated drug in contrast to a non-PEGylated one are significantly different. The half-time in plasma is, therefore, significantly longer.

References:

→ Drug delivery systems for RNA therapeutics; K. Paunovska, D. Loughrey, J. E. Dahlman; Nat. Rev. Genetics 2022; 23: 265-280. arrow-up-right-from-square https://doi.org/10.1038/s41576-021-00439-4

→ Drug delivery systems in cancer therapy; B. Qorri, A. DeCarlo, M. Mellon, M. R. Szewczuk; Drug Delivery Devices and Therapeutic Systems 2021; 423-454. arrow-up-right-from-square https://doi.org/10.1016/b978-0-12-819838-4.00016-x

→ Chapter One - Molecular platforms for targeted drug delivery; K. Maso, A. Grigoletto, M. J. Vicent, G. Pasut; International Review of Cell and Molecular Biology L. Galluzzi 2019; 346: 1-50. arrow-up-right-from-square https://doi.org/10.1016/bs.ircmb.2019.03.001

PEGylation

→ Polymer-drug conjugate therapeutics: advances, insights and prospects; I. Ekladious, Y. L. Colson, M. W. Grinstaff; Nat. Rev. Drug discovery 2019; 18: 273-294. arrow-up-right-from-square https://doi.org/10.1038/s41573-018-0005-0

→ Polymer Therapeutics: Design, Application, and Pharmacokinetics; B. A. Aderibigbe, H. E. Mukaya; Nano- and Microscale Drug Delivery Systems A. M. Grumezescu 2017: 33-48. arrow-up-right-from-square https://doi.org/10.1016/b978-0-323-52727-9.00003-0

→ Structure of a PEGylated protein reveals a highly porous double-helical assembly; G. Cattani, L. Vogeley, P. B. Crowley; Nat Chem 2015; 7: 823-8. arrow-up-right-from-square https://doi.org/10.1038/nchem.2342

→ An Overview Of Polymer Therapeutics; G. Srinivasan, M. Vaishnavi; World Journal of Pharmaceutical Research 2014; 3: 1446-1467.

→ Polymer therapeutics: Top 10 selling pharmaceuticals — What next?; R. Duncan; Journal of Controlled Release 2014; 190: 371-380. arrow-up-right-from-square https://doi.org/10.1016/j.jconrel.2014.05.001

→ Polymer therapeutics-prospects for 21st century: The end of the beginning; R. Duncan, M. J. Vicent; Advanced Drug Delivery Reviews 2013; 65: 60-70. arrow-up-right-from-square https://doi.org/10.1016/j.addr.2012.08.012

→ Bioconjugate Techniques (Third Edition); G. T. Hermanson; G. T. Hermanson 2013: 1146. arrow-up-right-from-square https://doi.org/10.1016/C2009-0-64240-9

→ Polymer-Based Therapeutics; S. Liu, R. Maheshwari, K. L. Kiick; Macromolecules 2009; 42: 3-13. arrow-up-right-from-square https://doi.org/10.1021/ma801782q

→ The dawning era of polymer therapeutics; R. Duncan; Nat. Rev. Drug discovery 2003; 2: 347-60. arrow-up-right-from-square https://doi.org/10.1038/nrd1088

1.3. Chemical and Physical Properties of PEG Polymers

The most important parameter describing a polymer is the degree of polymerization “DP”. DP describes the number of monomeric units in a polymer molecule. If a polymer consists of only one single molecular weight species (a defined number n of repeating units), the polymer is called “homopolymer” or “uniform”. A common term previously used is “monodisperse”. Most polymers consist of a range of species with an average mass and a distribution of n around a mean value. These polymers are referred to as “polydisperse”, “disperse”, or “non-uniform”. If the polymer is polydisperse, its mass spectrum will show a range of different molecular weights as shown in a typical mass spectrum Fig. 4:

Fig. 3: Structure example of a PEG with DP = n.

Fig. 4: Mass spectrum of a PEG showing the typical signals with a difference of m/z = 44.

A measure of the distribution of molecular weights in a polymer is given by the Polydispersity or simply dispersity Đ, which is defined as the ratio between the weight average molecular weight M°w and the number average molecular weight M°n :

The weight average M°w does not “count” species just by their number but considers the total weight of each species and is therefore a much more realistic indicator of the gross mechanical properties of a polymer. In case of a homopolymer with a defined chain length, M°w is equal to M°n , thus the dispersity Đ equals 1.00 and the compound is referred to as uniform. Whenever there is a distribution of molecular weights, the weight average M°w is always higher than the number average M°n , and consequently the dispersity Đ is greater than 1.00. The dispersity of polymers typically used in polymer therapeutics ranges between 1.01 and 1.20.

Generally, a rather low Đ value close to 1.00 is aspired as it is an indication for a well-controlled and mastered polymerization process. However, such a narrow weight distribution is not always of advantage in practice. For the formation of some nanostructures, it may be necessary to have a rather broad distribution of molecule sizes, resulting in a rather high dispersity Đ. For example, some polymers can form spheric nanoparticles when used at high dispersity but will form fibrils if used in a dispersity close to 1.00. In other applications, it may be necessary to have material with very low dispersity. In order to reach reproducible results, it is crucial to work with highly pure polymers of good batch-tobatch reproducibility.

References:

→ Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications; A. Birke, J. Ling, M. Barz; Progress in Polymer Science 2018; 81: 163-208. arrow-up-right-from-square https://doi.org/10.1016/j.progpolymsci.2018.01.002

→ Fundamentals of Polymer Science: An Introductory Text; P. C. Painter, M. M. Coleman; 1997: 22. arrow-up-right-from-square https://doi.org/10.1201/9780203755211

1.4. Quality Parameters of PEG Polymers

For a small molecule, typically a rather limited set of analytical parameters (for example: purity by HPLC, identity by NMR or mass spectroscopy, and residual solvents content) is sufficient to describe the quality of each material batch.

For a polymer, a much more sophisticated analysis is necessary to describe the quality of the material comprehensively. Depending on the application’s needs and on authorities’ demand, the certificate of analysis for a therapeutic polymer may contain dozens of different analytical parameters.

The development of analytical methods and processes requires an extensive understanding of the polymer itself and about the expressiveness of the various analytical parameters.

For our therapeutic polymers, the analytical laboratory is staffed by highly-qualified personnel who use equipment specially focused, but not limited, to the quality control of polymers. All instruments are qualified, and the validated analysis conforms to international and European standards.

PEGylation

1.5.

Modes of Polymer Application

During the last decades, PEG and several other polymers have entered the field of drug delivery: natural and nonnatural ones, biodegradable and non-degradable ones, such as: proteins, poly(amino acids), peptides, peptoids, polysaccharides, modified cellulose derivatives, polyesters, polyamides, polyanhydrides, polyphosphonates, polyacrylates, and many more. Independent of their chemical nature, polymer therapeutics can be classified by their mode of application:

Polymeric Drugs

The polymer itself is the active pharmaceutical ingredient. One market approved example is Copaxone®, a random copolymer of alanine, Glutamate, lysine, and tyrosine for the treatment of multiple sclerosis.

Polymer-Drug Conjugates

Here, a polymer backbone carries one or several active moieties, as for example in Opaxio®, a poly (glutamic acid)-Paclitaxel conjugate for cancer treatment.

Polymer-Protein Conjugates

One or several polymer chains are attached to a protein, peptide, or antibody, as for example in Pegasys®, a PEGylated Interferon α 2a for the treatment of Hepatitis C.

Polymer-Based Hydrogels

Some polymers can be used to form hydrogels of defined pore size, water content, life-time and many more properties. Such hydrogels can be used to cage active ingredients, keep them perfectly hydrated, regulate their skin or tissue permeation, dose their release, and thus optimize their function. Often, such hydrogels are used in cosmetic applications.

Polymer-Based Nanoparticles

These nanoparticles are typically formed by a mixture of different lipid and polymer types and can form - among others - micelles (consisting of a monolayer), liposomes (consisting of a bilayer), or lipid nanoparticles “LNPs” (composed of multiple lipid layers as well as microdomains of lipid and nucleic acid). Examples for such nanoparticles are the latest mRNA-based SARS-CoV2 vaccines from Moderna, BioNTech/Pfizer or CureVac.

Fig. 5: Schematic representation of nanoparticles: micelle, liposome and lipid nanoparticle (from left to right).

These different application modes already point out that polymer therapeutics offer far more possibilities than the simple shielding and enlarging effects previously mentioned.

Concentration Effect

A large polyvalent polymeric carrier can enable the attachment of several active moieties on one macromolecule. If, for example, the pharmaceutical role of the active ingredient is to bind and block a surface receptor, the presence of several binding ligands will significantly increase the binding energy and thus lead to a more efficient receptor binding. As non-covalent receptor binding is a dynamic equilibrium of association and dissociation, a released single small molecule can easily be departed by the bloodstream and thus be prevented from re-binding. However, if it is part of a polymer which binds to the cell surface by several other of its binding moieties, it will not diffuse away, but will re-bind quickly to any free receptor on the surface.

Targeting Effect

A polymer carrier can be equipped both with a targeting moiety and with active molecules. For example, an RGD peptide can guide the polymer to cancer cells. After internalization, several bound cytotoxic molecules such as Paclitaxel can be released to kill the abnormal cell.

Shuttle Effect

An intelligent design of the drug delivery system can help transporting a payload to destinations where it could not go without the polymer’s help. There are systems that help crossing the skin barrier, some poly(amino acids) can help small molecules to cross cell membranes, LNPs as nonviral vectors can even transport DNA and RNA into living cells, and other polymers help crossing the blood-brain-barrier.

Combination Effect

Some cells develop resistance to a pharmaceutical treatment. If this happens, the treatment must be changed to a new strategy and cells may subsequently also develop resistance to the altered therapy. However, in polymer therapeutics, the two different active ingredients can be attached to one polymer. The simultaneous delivery of two different active cargos strongly suppresses the formation of resistances, because cells would have to develop both resistances at the same time, which is almost impossible.

PEGylation

References:

→ Drug delivery systems for RNA therapeutics; K. Paunovska, D. Loughrey, J. E. Dahlman; Nat. Rev. Genetics 2022; 23: 265-280. arrow-up-right-from-square https://doi.org/10.1038/s41576-021-00439-4

→ Polymer-based non-viral vectors for gene therapy in the skin; L. Tortajada, C. Felip-León, M. J. Vicent; Polymer Chemistry 2022; 13: 718-735. arrow-up-right-from-square https://doi.org/10.1039/D1PY01485D

→ Polyamide/Poly(Amino Acid) Polymers for Drug Delivery; S. H. S. Boddu, P. Bhagav, P. K. Karla, S. Jacob, M. D. Adatiya, T. M. Dhameliya, K. M. Ranch, A. K. Tiwari; Journal of Functional Biomaterials 2021; 12: 58. arrow-up-right-from-square https://doi.org/10.3390/jfb12040058

→ Polypeptides as building blocks for image-guided nanotherapies; I. Conejos-Sánchez, S. Đorđević, M. Medel, M. J. Vicent; Current Opinion in Biomedical Engineering 2021; 20: 100323. arrow-up-right-from-square https://doi.org/10.1016/j.cobme.2021.100323

→ Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery; T. Holmstrom, M. Galsgaard Malle, S. Wu, K. J. Jensen, N. S. Hatzakis, C. M. Pedersen; Chemistry 2021. arrow-up-right-from-square https://doi.org/10.1002/chem.202005332

→ From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases; E. H. Pilkington, E. J. A. Suys, N. L. Trevaskis, A. K. Wheatley, D. Zukancic, A. Algarni, H. Al-Wassiti, T. P. Davis, C. W. Pouton, S. J. Kent, N. P. Truong; Acta Biomater 2021; 131. arrow-up-right-from-square https://doi.org/10.1016/j.actbio.2021.06.023

→ Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2; T. A. Tummino, V. V. Rezelj, B. Fischer, A. Fischer, M. J. O’Meara, B. Monel, T. Vallet, K. M. White, Z. Zhang, A. Alon, H. Schadt, H. R. O’Donnell, J. Lyu, R. Rosales, B. L. McGovern, R. Rathnasinghe, S. Jangra, M. Schotsaert, J.-R. Galarneau, N. J. Krogan, L. Urban, K. M. Shokat, A. C. Kruse, A. García-Sastre, O. Schwartz, F. Moretti, M. Vignuzzi, F. Pognan, B. K. Shoichet; Science 2021; 373: 541-547. arrow-up-right-from-square https://doi.org/10.1126/science.abi4708

→ The evolution of commercial drug delivery technologies; A. M. Vargason, A. C. Anselmo, S. Mitragotri; Nature Biomedical Engineering 2021; 5: 951-967. arrow-up-right-from-square https://doi.org/10.1038/s41551-021-00698-w

→ A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy; W. Mu, Q. Chu, Y. Liu, N. Zhang; Nano-Micro Letters 2020; 12. arrow-up-right-from-square https://doi.org/10.1007/s40820-020-00482-6

→ Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery; S. S. Nogueira, A. Schlegel, K. Maxeiner, B. Weber, M. Barz, M. A. Schroer, C. E. Blanchet, D. I. Svergun, S. Ramishetti, D. Peer, P. Langguth, U. Sahin, H. Haas; ACS Applied Nano Materials 2020; 3: 10634-10645. arrow-up-right-from-square https://doi.org/10.1021/acsanm.0c01834

→ Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment; S. P. Atkinson, Z. Andreu, M. J. Vicent; J Pers Med 2018; 8: 6. arrow-up-right-from-square https://doi.org/10.3390/jpm8010006

→ A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules; S. M. Barros, S. K. Whitaker, P. Sukthankar, L. A. Avila, S. Gudlur, M. Warner, E. I. Beltrao, J. M. Tomich; Archives of biochemistry and biophysics 2016; 596: 22-42. arrow-up-right-from-square https://doi.org/10.1016/j.abb.2016.02.027

→ Peptide-Based Polymer Therapeutics; A. Duro-Castano, I. Conejos-Sánchez, M. Vicent; Polymers 2014; 6: 515-551. arrow-up-right-from-square https://doi.org/10.3390/polym6020515

→ Factors influencing in vivo disposition of polymeric micelles on multiple administrations; E. Hara, M. Ueda, A. Makino, I. Hara, E. Ozeki, S. Kimura; ACS Med Chem Lett 2014; 5: 873-7. arrow-up-right-from-square https://doi.org/10.1021/ml500112u

→ An Overview Of Polymer Therapeutics; G. Srinivasan, M. Vaishnavi; World Journal of Pharmaceutical Research 2014; 3: 1446-1467.

→ Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities; R. Duncan, M. J. Vicent; Adv Drug Deliv Rev 2010; 62: 272-82. arrow-up-right-from-square https://doi.org/10.1016/j.addr.2009.12.005

2. Amino-PEG-Acids, -Esters, & -Ethers

2.1. Unprotected Amino-PEG-Acids & -Esters

PEG1365 H2 N-PEG(2)-CO-Ot Bu

3-(2-(2-Aminoethoxy)ethoxy)propanoic acid t-butyl ester

CAS-No. 756525-95-8

Formula C11H23 NO4 Mol. weight 233,3 g/mol

PEG2420 H-O2Oc-OH

[2-(2-aminoethoxy)ethoxy]acetic acid

CAS-No. 134978-97-5

Formula C 6 H13 NO4 Mol. weight 163,17 g/mol

PEG7940 H-O2Oc-OH*HCl

8-amino-3,6-dioxaoctanoic acid hydrochloride

CAS-No. 134979-01-4

Formula C 6 H13 NO4*HCl Mol. weight 163,17*36,45 g/mol

PEG2430 H-O2Oc-Ot Bu*HCI

[2-(2-aminoethoxy)ethoxy]acetic acid tert-butyl ester*HCl

CAS-No. 2098500-69-5

Formula C10 H21NO4*HCI Mol. weight 219,28*36,45 g/mol

PEG1370 H2 N-PEG(4)-COOH

15-Amino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 663921-15-1

Formula C11H23 NO 6 Mol. weight 265,3 g/mol

PEGylation

PEG1375 H2 N-PEG(4)-CO-Ot Bu

15-Amino-4,7,10,13-tetraoxa-pentadecanoic acid t-butyl ester

CAS-No. 581065-95-4

Formula C15H31NO 6 Mol. weight 321,41 g/mol

PEG1221 H-O2Oc-O2Oc-OH

17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan1-oic acid

CAS-No. 1143516-05-5

Formula C12H24N2O 7 Mol. weight 308,33 g/mol

PEG1300 H2 N-PEG(6)-COOH

1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 905954-28-1

Formula C15H31NO 8 Mol. weight 353,41 g/mol

PEG1305 H2 N-PEG(6)-CO-Ot Bu

1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid t-butyl ester

CAS-No. 1286281-32-0

Formula C19 H39 NO 8 Mol. weight 409,51 g/mol

PEG2770 H-O2Oc-O2Oc-O2Oc-OH

26-amino-10,19-dioxo-3,6,12,15,21,24-hexaoxa-9,18-diazahexacosan-1-oic acid

CAS-No. 2773558-06-6

Formula C18 H35N3 O 10 Mol. weight 453,48 g/mol

PEG8060 H-O2Oc-O2Oc-O2Oc-O2Oc-OH

8-amino-3,6-dioxaoctanoic acid tetramer

CAS-No. 2773558-66-8

Formula C 24H46 N4O 13 Mol. weight 598,64 g/mol

PEG1380 H2 N-PEG(8)-COOH

1-Amino-3,6,9,12,15,18,21,24-octaoxaheptaeicosane-27-oic acid

CAS-No. 756526-04-2

Formula C19 H39 NO 10 Mol. weight 441,51 g/mol

PEG1385 H2 N-PEG(8)-CO-Ot Bu

1-Amino-3,6,9,12,15,18,21,24-octaoxaheptaeicosane-27-oic acid t-butyl ester

CAS-No. 756526-06-4

Formula C 23 H47NO 10 Mol. weight 497,62 g/mol

PEG1345 H2 N-PEG(12)-COOH

1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid

CAS-No. 1415408-69-3

Formula C 27H 55NO 14 Mol. weight 617,72 g/mol

PEG1350 H2 N-PEG(12)-CO-Ot Bu

1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid t-butyl ester

CAS-No. 872340-65-3

Formula C 31H 63 NO 14 Mol. weight 673,83 g/mol

PEG1355 H2 N-PEG(24)-COOH

alpha-Amino-24(ethylene glycol)-omega-propionic acid

CAS-No. 196936-04-6

Formula C 51H103 NO 26 Mol. weight 1146,38 g/mol

PEG1360 H2 N-PEG(24)-CO-Ot Bu

alpha-Amino-24(ethylene glycol)-omega-propionic acid t-butyl ester

CAS-No. 872340-65-3

Formula C 55H111NO 26 Mol. weight 1202,49 g/mol

PEGylation

PEG3340 H2 N-PEG(36)-COOH

alpha-Amino-omega-propionic acid-36(ethylen glycol)

CAS-No. 196936-04-6

Formula C 75H151NO 38 Mol. weight 1674,99 g/mol

PEG3710 H2 N-PEG(36)-CO-Ot Bu

alpha-Amino-omega-(t-butyl propionate) 36(ethylene glycol)

CAS-No. 872340-65-3

Formula C 79 H159 NO 38 Mol. weight 1731,09 g/mol

PEG7055 H2 N-PEG(24)-amido-PEG(24)-COOH

1-amino-75-oxo- 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,4 8,51,54,57,60,63,66,69,72,79,82,85,88,91,94,97,100,103,106 ,109,112,115,118,121,124,127,130,133,136,139,142,145,148-octatetracontaoxa-76-azah enpentacontahectan-151-oic acid

Formula C102H204N2O 51 Mol. weight 2274,72 g/mol

PEG1096 H2 N-PEG-COOH*HCl (3 kDa)

alpha-Amino-omega-carboxy poly(ethylene glycol) hydrochloride

CAS-No. 757186-20-2 net Mol. weight 3000 Da

PEG1097 H2 N-PEG-COOH*HCl (5 kDa)

alpha-Amino-omega-carboxy poly(ethylene glycol) hydrochloride

CAS-No. 757186-20-2 net Mol. weight 5000 Da

PEG1095 H2 N-PEG-COOH*HCl (10 kDa)

alpha-Amino-omega-carboxy poly(ethylene glycol) hydrochloride

CAS-No. 757186-20-2 net Mol. weight 10000 Da

2.2. Aloc-Amino-PEG-Acids

AAA1905 Aloc-O2Oc-OH*DCHA

8-(Allyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylamine

CAS-No. 560088-74-6

Formula C10 H17NO 6*C12H23 N Mol. weight 247,11*181,32 g/mol

2.3. Boc-Amino-PEG-Acids & -Esters

BAA5240 Boc-O1Pen-OH*DCHA

5-(t-Butyloxycarbonyl-amino)-3-oxapentanoic acid DCHA

CAS-No. 142929-49-5

Formula C9 H17NO 5*C12H23 N Mol. weight 219,24*181,32 g/mol

BAA6070 Boc,Pbf-amidino-O1Pen-OH

5-[N-t-Butyloxycarbonyl-N‘-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]amidino-3-oxapentanoic acid

CAS-No. 1263049-05-3

Formula C 23 H35N3 O 8 S Mol. weight 513,61 g/mol

PEG8080 Boc-O2Oc-OH

(2-(2-(t-Butyloxycarbonylamino)ethoxy)ethoxy)acetic acid

CAS-No. 108466-89-3

Formula C11H21NO 6 Mol. weight 263,29 g/mol

Product details

PEGylation

BAA1466 Boc-O2Oc-OH*DCHA

8-(t-Butyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylammonium salt

CAS-No. 560088-79-1

Formula C11H21NO 6*C12H23 N Mol. weight 263,29*181,32 g/mol

BAA6080 Boc,Pbf-amidino-O2Oc-OH

8-[N-t-Butyloxycarbonyl-N‘-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]amidino-3,6-dioxaoctanoic acid

CAS-No. 1263049-06-4

Formula C 25H39 N3 O 9 S Mol. weight 557,66 g/mol

PEG4930 Boc-NH-PEG(3)-COOH

1-(t-Butyloxycarbonyl)amino-3,6,9-trioxadodecan-12oic acid

CAS-No. 1347750-75-7

Formula C14H27NO 7 Mol. weight 321,37 g/mol

PEG1920

Boc-NH-PEG(4)-COOH

15-t-Butyloxycarbonylamino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 756525-91-4

Formula C16 H31NO 8 Mol. weight 365,42 g/mol

BAA1485

Boc-O2Oc-O2Oc-OH

17-(t-Butyloxycarbonyl-amino)-9-aza-3,6,12,15-tetraoxa-10-on-heptadecanoic acid

CAS-No. 1069067-08-8

Formula C17H32N2O 9 Mol. weight 408,45 g/mol

BAA4910

Boc-O2Oc-O2Oc-O2Oc-OH

2,2-dimethyl-6,13,22-trioxo-3,8,11,17,20,26,29-heptaoxa-5,14,23-triazahentriacontan-31-oic acid

Formula C 23 H43 N3 O 12 Mol. weight 553,61 g/mol

PEG4920

Boc-NH-PEG(5)-COOH

1-(t-Butyloxycarbonyl)amino-3,6,9,12,15-pentaoxaoctadecan-18-oic acid

CAS-No. 1347750-78-0

Formula C18 H35NO 9 Mol. weight 409,47 g/mol

PEG4910

Boc-NH-PEG(6)-COOH

1-(t-Butyloxycarbonyl)amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 882847-13-4

Formula C 20 H39 NO 10 Mol. weight 453,52 g/mol

PEG2410

Boc-NH-PEG(8)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy octa(ethylene glycol)

CAS-No. 1334169-93-5

Formula C 24H47NO 12 Mol. weight 541,63 g/mol

PEG1071

Boc-NH-PEG(8)-COOH

alpha-t-Butyloxycarbonylamino-omega-diglycolic acid octa(ethylene glycol)

CAS-No. 600141-83-1

Formula C 25H48 N2O 13 Mol. weight 584,67 g/mol

PEG1070

Boc-NH-PEG(12)-COOH

alpha-t-Butyloxycarbonylamino-omega-[(aminocarboxymethoxy)acetic acid] dodecae(ethylene glycol)

Formula C 33 H 64N2O 17

Mol. weight 760,88 g/mol

PEG2415

Boc-NH-PEG(12)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy dodeca(ethylene glycol)

CAS-No. 187848-68-6

Formula C 32H 63 NO 16 Mol. weight 717,84 g/mol

PEGylation

PEG4480

Boc-NH-PEG(24)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy 24(ethylene glycol)

CAS-No. 187848-68-6

Formula C 56 H111NO 28 Mol. weight 1246,47 g/mol

PEG1995

Boc-NH-PEG(27)-COOH

alpha-t-Butyloxycarbonylamino-27(ethylene glycol)-omega-propionic acid

CAS-No. 2941512-89-4

Formula C 64H127NO 32 Mol. weight 1422,71 g/mol

PEG4490

Boc-NH-PEG(36)-COOH

alpha-t-Butyloxycarbonylamino-omega-carboxy 36(ethylene glycol)

CAS-No. 187848-68-6

Formula C 80 H159 NO40 Mol. weight 1775,1 g/mol

PEG1073

Boc-NH-PEG-COOH (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy poly(ethylene glycol)

CAS-No. 1626344-87-3 Mol. weight 3000 Da

PEG1074

Boc-NH-PEG-COOH (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1072

Boc-NH-PEG-COOH (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy poly(ethylene glycol)

CAS-No. 1626344-87-3 Mol. weight 10000 Da

PEG1111

Boc-NH-PEG-NHS (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1310917-19-1

Mol. weight 3000 Da

PEG1112

Boc-NH-PEG-NHS (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1310917-19-1

Mol. weight 5000 Da

PEG1110

Boc-NH-PEG-NHS (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1310917-19-1

Mol. weight 10000 Da

2.4. Dde-Amino-PEG-Acids

8-[(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl-amino]-3,6-dioxaoctanoic acid, {2-[2-(Dde-amino) ethoxy]ethoxy}acetic acid

CAS-No. 1263045-93-7

Formula C16 H25NO 6 Mol. weight 327,37 g/mol

2.5. Dnp-Amino-PEG-Acids & -Esters

PEG2145 Dnp-NH-PEG(4)-COOH

1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid

CAS-No. 858126-76-8

Formula C17H25N3 O 10 Mol. weight 431,39 g/mol

PEG2150 Dnp-NH-PEG(4)-NHS

1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester

CAS-No. 858126-78-0

Formula C 21H28 N4O 12 Mol. weight 528,47 g/mol

PEG2285 Dnp-NH-PEG(12)-COOH

alpha-(2,4-Dinitrophenyl)amino-omega-carboxy dodeca(ethylene glycol)

CAS-No. 1334178-00-5

Formula C 33 H 57N3 O 18 Mol. weight 783,81 g/mol

PEG2290 Dnp-NH-PEG(12)-NHS

alpha-(2,4-Dinitrophenyl)amino-omega-succinimidyl ester dodeca(ethylene glycol)

CAS-No. 1334178-01-6

Formula C 34H 60 N4O 20 Mol. weight 880,89 g/mol

2.6.

DOTA-Amino-PEG-Acids

& -Esters

PEG6880 DOTA-PEG(4)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-tetra(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

CAS-No. 2389064-50-8 net

Formula C 33 H49 F4N 5 O 13*2CF 3 CO 2H Mol. weight 799,76*228,05 g/mol

PEG6890 DOTA-PEG(12)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-dodeca(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

Formula C 49 H 81F4N 5 O 21*2CF 3 CO 2H Mol. weight 1152,18*228,05 g/mol

PEG6860 DOTA(t Bu3)-PEG(12)-TFP

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-dodeca(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate)

Formula C 61H105F4N 5 O 21 Mol. weight 1320,5 g/mol

PEG6900 DOTA-PEG(24)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-24(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

Formula C 73 H129 F4N 5 O 33*2CF 3 CO 2H Mol. weight 1680,81*228,05 g/mol

PEG6870 DOTA(t Bu3)-PEG(24)-TFP

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-24(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate)

Formula C 85H153 F4N 5 O 33

Mol. weight 1849,13 g/mol

2.7. Fmoc-Amino-PEG-Acids & -Esters

FAA1565 Fmoc-O1Pen-OH

5-(9-Fluorenylmethyloxycarbonyl-amino)-3-oxapentanoic acid

CAS-No. 260367-12-2

Formula C19 H19 NO 5 Mol. weight 341,37 g/mol

FAA1435 Fmoc-O2Oc-OH

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

CAS-No. 166108-71-0

Formula C 21H23 NO 6 Mol. weight 385,42 g/mol

PEG1810 Fmoc-AEEP

3-(2-(2-(9-Fluorenylmethyloxycarbonyl)aminoethoxy) ethoxy)propanoic acid

CAS-No. 872679-70-4

Formula C 22H25NO 6 Mol. weight 399,44 g/mol

PEG4970 Fmoc-Ebes

N-[8-(9-Fluorenylmethyloxycarbonyl)amino-3,6-dioxaoctyl]succinamic acid

CAS-No. 613245-91-3

Formula C 25H30 N2O 7 Mol. weight 470,51 g/mol

PEG5180 Fmoc-DOOA-DIG-OH

2-(2-(2-(2-((9-Fluorenylmethyloxycarbonyl)amino) ethoxy)ethoxy)ethylamino)-diglycolic acid

CAS-No. 669073-64-7

Formula C 25H30 N2O 8 Mol. weight 486,51 g/mol

PEG4370 Fmoc-NH-PEG(3)-COOH

12-(9-Fluorenylmethyloxycarbonylamino)-4,7,10-trioxa-dodecanoic acid

CAS-No. 867062-95-1

Formula C 24H29 NO 7 Mol. weight 443,49 g/mol

PEG8200 Fmoc-NMe-PEG(3)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9-trioxydodecan-12-oic acid

CAS-No. 1807518-77-9

Formula C 25H31NO 7 Mol. weight 457,52 g/mol

RL-4400

Fmoc-NH-PEG(3)-NH-Suc-OH

1-(9H-fluoren-9-yl)-3,17-dioxo-2,7,10,13-tetraoxa-4,16diazaicosan-20-oic acid

CAS-No. 1653992-32-5

Formula C 27H34N2O 8 Mol. weight 514,57 g/mol

RL-4410 Fmoc-NH-PEG(3)-DIG-OH

1-(9H-fluoren-9-yl)-3,17-dioxo-2,7,10,13,19-pentaoxa-4,16-diazahenicosan-21-oic acid

CAS-No. 489427-26-1

Formula C 27H34N2O 9 Mol. weight 530,57 g/mol

FAA1568 Fmoc-TTDS-OH

[N1-(9-Fluorenylmethoxycarbonyl)-1,13-diamino-4,7,10-trioxatridecan-succinamic acid

CAS-No. 172089-14-4

Formula C 29 H38 N2O 8 Mol. weight 542,63 g/mol

PEG1820 Fmoc-NH-PEG(4)-COOH

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 557756-85-1

Formula C 26 H33 NO 8 Mol. weight 487,54 g/mol

PEGylation

PEG8210

Fmoc-NMe-PEG(4)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12-tetraoxypentadecan-15-oic acid

CAS-No. 2170240-98-7

Formula C 27H35NO 8 Mol. weight 501,58 g/mol

PEG4410 Fmoc-NH-PEG(4)-NHS

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 1314378-14-7

Formula C 30 H36 N2O 10 Mol. weight 584,24 g/mol

PEG7810 Fmoc-NH-PEG(4)-TFP

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoic acid (2,3,5,6-tetrafluorophenyl) ester

CAS-No. 2247993-77-5

Formula C 32H33 F4NO 8 Mol. weight 635,6 g/mol

FAA1787 Fmoc-O2Oc-O2Oc-OH

17-(9-Fluorenylmethyloxycarbonyl-amino)-9-aza-3,6,12,15-tetraoxa-10-on-heptadecanoic acid

CAS-No. 560088-89-3

Formula C 27H34N2O 9 Mol. weight 530,58 g/mol

PEG6825 Fmoc-O2Oc-O2Oc-O2Oc-OH

Fmoc-8-amino-3,6-dioxaoctanoic acid trimer

CAS-No. 2379531-43-6

Formula C 33 H45N3 O 12 Mol. weight 675,73 g/mol

PEG4380 Fmoc-NH-PEG(5)-COOH

18-(9-Fluorenylmethyloxycarbonylamino)-4,7,10, 13-tetraoxa-octadecanoic acid

CAS-No. 882847-32-7

Formula C 28 H37NO 9 Mol. weight 531,59 g/mol

PEG8220 Fmoc-NMe-PEG(5)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15-pentaoxyoctadecan-18-oic acid

CAS-No. 2990879-77-9

Formula C 29 H39 NO 9 Mol. weight 545,63 g/mol

PEG1825 Fmoc-NH-PEG(6)-COOH

1-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 882847-34-9

Formula C 30 H41NO 10 Mol. weight 575,65 g/mol

PEG8230 Fmoc-NMe-PEG(6)-COOH

N-methyl-(9-Fluorenylmethyloxycarbonyl)amino3,6,9,12,15,18-henicosan-21-oic acid

Formula C 31H43 NO 10 Mol. weight 589,68 g/mol

PEG1830 Fmoc-NH-PEG(8)-COOH

1-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid

CAS-No. 756526-02-0

Formula C 34H49 NO 12

Mol. weight 663,75 g/mol

PEG4420 Fmoc-NH-PEG(8)-NHS

alpha-(Fmoc-amino)-omega-(succinimidyl propionate) octa(ethylene glycol)

CAS-No. 1334170-03-4

Formula C 38 H 52N2O 14 Mol. weight 760,82 g/mol

PEG7820 Fmoc-NH-PEG(8)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) octa(ethylene glycol)

CAS-No. 2569294-35-3

Formula C 40 H49 F4NO 12 Mol. weight 811,81 g/mol

PEGylation

PEG1080 Fmoc-NH-PEG(12)-COOH

1-(9-Fluorenylmethyloxycarbonyl)amino-3,6,9,12,15,18,2 1,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid

CAS-No. 1952360-91-6

Formula C 42H 65NO 16 Mol. weight 839,98 g/mol

PEG4430 Fmoc-NH-PEG(12)-NHS

alpha-(Fmoc-amino)-omega-(succinimidyl propionate) dodeca(ethylene glycol)

CAS-No. 488085-18-3

Formula C 46 H 68 N2O 18 Mol. weight 937,03 g/mol

PEG7830 Fmoc-NH-PEG(12)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) dodeca(ethylene glycol)

Formula C 48 H 65F4NO 16 Mol. weight 988,02 g/mol

PEG1210 Fmoc-NH-PEG(27)-COOH

alpha-(9-Fluorenylmethyloxycarbonyl)amino-27(ethylene glycol)-omega-propionic acid

CAS-No. 2101605-02-9

Formula C 74H129 NO 32 Mol. weight 1544,8 g/mol

PEG1815 Fmoc-NH-PEG(24)-COOH

alpha-Fmoc-amino-24(ethylene glycol)-omega-carboxylic acid

CAS-No. 2170484-59-8

Formula C 66 H113 NO 28 Mol. weight 1368,63 g/mol

PEG7840 Fmoc-NH-PEG(24)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) 24(ethylene glycol)

Formula C 72H113 F4NO 28 Mol. weight 1516,65 g/mol

PEG4400 Fmoc-NH-PEG(36)-COOH

alpha-Fmoc-amino-36(ethylene glycol)-omega-carboxylic acid

CAS-No. 850312-72-0

Formula C90 H161NO40 Mol. weight 1897,22 g/mol

PEG7850 Fmoc-NH-PEG(36)-TFP

alpha-(Fmoc-amino)-omega-(2,3,5,6-tetrafluorophenyl propionate) 36(ethylene glycol)

Formula C96 H161F4NO40 Mol. weight 2045,28 g/mol

PEG7035 Fmoc-amido-PEG(24)-amido-PEG(24)-COOH

1-(9H-fluoren-9-yl)-3,79-dioxo- 2,7,10,13,16,19,22,25,28,3 1,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,83,86,89,9 2,95,98,101,104,107,110,113,116,119,122,125,128,131,134,137, 140,143,146,149,152-nona tetracontaoxa-4,80-diazapentapentacontahectan-155-oic aci

CAS-No. 2978678-76-9

Formula C117H214N2O 53 Mol. weight 2496,96 g/mol

PEG1108

Fmoc-NH-PEG-COOH (3 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy poly(ethylene glycol)

CAS-No. 1432477-83-2

Mol. weight 3000 Da

PEG1109

Fmoc-NH-PEG-COOH (5 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy poly(ethylene glycol)

CAS-No. 1432477-83-2

Mol. weight 5000 Da

PEGylation

PEG1117

Fmoc-NH-PEG-NHS (3 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1300707-12-3 Mol. weight 3000 Da

PEG1118 Fmoc-NH-PEG-NHS (5 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1300707-12-3 Mol. weight 5000 Da

PEG1116 Fmoc-NH-PEG-NHS (10 kDa)

alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1300707-12-3 Mol. weight 10000 Da

2.8. Mtt-Amino-PEG-Acids

PEG4650 Mtt-O2Oc-OH*DEA

N-(4-Methyltrity)-8-amino-3,6-dioxaoctanoic acid diethylamine

CAS-No. 2098500-66-2

Formula C 26 H29 NO4*C 4H11N Mol. weight 419,51*73,14 g/mol

PEG2161 Mtt-NH-PEG(4)-COOH*TEA

1-( p-Methytritylamino)-3,6,9,12-tetraoxapentadecanoic acid triethylamionium salt

CAS-No. 1310680-33-1 (net)

Formula C 31H39 NO 6*C 6 H15N

Mol. weight C31H39NO6*C6H15N g/mol

2.9. Z-Amino-PEG-Acids

PEG4710 Z-O1Pen-OH

5-(Benzyloxycarbonyl-amino)-3-oxa-pentanoic acid

CAS-No. 1260092-43-0

Formula C12H 5NO 5 Mol. weight 253,25 g/mol

ZAA1186 Z-O2Oc-OH*DCHA

8-(Benzyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylamine

CAS-No. 560088-84-8

Formula C14H19 NO 6*C12H23 N Mol. weight 297,31*181,32 g/mol

PEG1495 Z-NH-PEG(4)-COOH

15-Benzyloxycarbonylamino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 756526-00-8

Formula C19 H29 NO 8 Mol. weight 399,44 g/mol

PEG1795 Z-NH-PEG(6)-COOH

1-Benzyloxycarbonylamino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

CAS-No. 1334177-80-8

Formula C 23 H37NO 10 Mol. weight 487,54 g/mol

PEG1800 Z-NH-PEG(8)-COOH

1-Benzyloxycarbonylamino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid

CAS-No. 1334177-87-5

Formula C 27H45NO 12 Mol. weight 575,65 g/mol

PEGylation

PEG1785 Z-NH-PEG(12)-COOH

1-Benzyloxycarbonylamino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid

CAS-No. 1334177-88-6

Formula C 35H 61NO 16 Mol. weight 751,86 g/mol

PEG1790 Z-NH-PEG(24)-COOH

alpha-Benzyloxycarbonylamino-24(ethylene glycol)-omega-propionic acid

CAS-No. 1334177-88-6

Formula C 59 H109 NO 28 Mol. weight 1280,52 g/mol

PEG4590 Z-NH-PEG(36)-COOH

alpha-Benzyloxycarbonylamino-amino-36(ethylene glycol)-omega-carboxylic acid

CAS-No. 1334177-88-6

Formula C 83 H157NO40 Mol. weight 1809,12 g/mol

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3. PEG-Acids & -Esters

3.1. Unprotected Hydroxy-PEG-Acids & -Esters

PEG1535

HO-PEG(4)-CO-Ot Bu

15-Hydroxy-4,7,10,13-tetraoxa-pentadecanoic acid t-butyl ester

CAS-No. 518044-32-1

Formula C15H30 O 7 Mol. weight 322,39 g/mol

PEG7220 HO-PEG(4)-TFP

Hydroxy-tetra(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenyl ester

CAS-No. 2130036-53-0

Formula C17H22F4O 7 Mol. weight 414,35 g/mol

PEG2355

HO-PEG(6)-CO-Ot Bu

alpha-Hydroxy-omega-carboxy t-butyl ester hexa(ethylene glycol)

CAS-No. 361189-64-2

Formula C19 H38 O 9 Mol. weight 410,5 g/mol

PEG1540

HO-PEG(8)-CO-Ot Bu

t-Butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

CAS-No. 1334177-84-2

Formula C 23 H46 O 11 Mol. weight 498,6 g/mol

PEG1090 HO-PEG(12)-CO-Ot Bu

alpha-Hydroxy-omega-t-butyl propionat dodecae(ethylene glycol)

CAS-No. 1186025-29-5

Formula C 31H 62O 15 Mol. weight 674,81 g/mol

PEGylation

PEG2360

HO-PEG(12)-COO-t Bu

alpha-Hydroxy-omega-carboxy t-butyl ester dodeca(ethylene glycol)

CAS-No. 1186025-29-5

Formula C 31H 62O 15 Mol. weight 674,81 g/mol

PEG7230

HO-PEG(12)-TFP

Hydroxy-dodeca(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenyl ester

Formula C 33 H 54F4O 15 Mol. weight 766,77 g/mol

PEG2365

HO-PEG(24)-CO-t Bu

alpha-Hydroxy-omega-carboxy t-butyl ester 24(ethylene glycol)

CAS-No. 1186025-29-5

Formula C 55H110 O 27 Mol. weight 1203,45 g/mol

PEG7240 HO-PEG(24)-TFP

Hydroxy-24(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenyl ester

Formula C 57H102F4O 27 Mol. weight 1295,4 g/mol

PEG1093

HO-PEG-COOH (3 kDa)

alpha-Hydroxy-omega-carboxy poly(ethylene glycol)

CAS-No. 943222-05-7 Mol. weight 3000 Da

PEG1094

HO-PEG-COOH (5 kDa)

alpha-Hydroxy-omega-carboxy poly(ethylene glycol)

CAS-No. 943222-05-7 Mol. weight 5000 Da

PEG1092 HO-PEG-COOH (10 kDa)

alpha-Hydroxy-omega-carboxy poly(ethylene glycol)

CAS-No. 943222-05-7 Mol. weight 10000 Da

PEG6610 HO-PEG-SQA (3 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1421319-95-0 Mol. weight 3000 Da

PEG6615 HO-PEG-SQA (5 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1421319-95-0 Mol. weight 5000 Da

PEG6600 HO-PEG-SQA (10 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1421319-95-0 Mol. weight 10000 Da

PEG6605 HO-PEG-SQA (20 kDa)

alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1421319-95-0 Mol. weight 20000 Da

3.2. PEG-Dicarboxylic Acids & -Esters

PEG1985 DIG(Pfp)2

2,2‘-Oxydiacetic acid bis-pentafluorophenyl ester

CAS-No. 158573-58-1

Formula C16 H4F 10 O 5

Mol. weight 466,18 g/mol

PEG1990 DIG(NHS)2

2,2‘-Oxydiacetic acid bis-N-succinimidyl ester

CAS-No. 373614-12-1

Formula C12H12N2O 9 Mol. weight 328,23 g/mol

PEG4120 NHS-PEG(2)-NHS

3,6-Dioxaoctandioic acid bissuccinimidyl ester

CAS-No. 65869-63-8

Formula C16 H20 N2O 10 Mol. weight 400,34 g/mol

PEG4130 NHS-PEG(3)-NHS

3,6,9-Trioxaundecandioic acid bissuccinimidyl ester

CAS-No. 1314378-16-9

Formula C18 H24N2O 11 Mol. weight 444,39 g/mol

PEG4041 Tfp-PEG(4)-Tfp

alpha,omega-Bis(tertrafluorphenyl propionate) tri(ethylene glycol)

CAS-No. 1446282-42-3

Formula C 24H22F8 O 8 Mol. weight 590,41 g/mol

PEG5090

NHS-PEG(5)-COOH

Succinimidyl-4,7,10,13,16-pentaoxanonadecane-1,19-dicarboxylic acid

CAS-No. 1343476-41-4

Formula C18 H29 NO 11

Mol. weight 435,42 g/mol

PEG1435

NHS-PEG(5)-NHS

Bis-succinimidyl-4,7,10,13,16-pentaoxanonadecane-1,19-dioate

CAS-No. 756526-03-1

Formula C 22H32N2O 13 Mol. weight 532,51 g/mol

PEG2115

NHS-PEG(5)-CO-OBzl

alpha-succinimidyl ester-omega-carboxy benzyl ester penta(ethylene glycol)

CAS-No. 1263044-84-3

Formula C 25H35NO 11 Mol. weight 525,55 g/mol

PEG3970

NHS-PEG(7)-NHS

Bis-succinimidyl-4,7,10,13,16,19,22-heptaoxa pentacosane-1,25-dioate

CAS-No. 1334170-02-3

Formula C 26 H40 N2O 15 Mol. weight 620,6 g/mol

PEG7710

NHS-PEG(9)-COOH

alpha-succinimidyl nona(ethylen glycol)-alpha,omega-bispropionic acid

CAS-No. 1895916-27-4

Formula C 26 H45NO 15 Mol. weight 611,63 g/mol

PEG1460

NHS-PEG(9)-NHS

Bis-succinimidyl-4,7,10,13,16,19,22,25,28-nonaoxahentriacontane-1,31-dioate

CAS-No. 1008402-79-6

Formula C 30 H48 N2O 17 Mol. weight 708,71 g/mol

PEGylation

PEG1091 HOOC-PEG(13)-COOH

alpha,omega-Bis(propionic acid) tridecae(ethylene glycol)

CAS-No. 51178-68-8

Formula C 30 H 58 O 17 Mol. weight 690,77 g/mol

PEG5100 NHS-PEG(13)-COOH

alpha-succinimidyl trideca(ethylene glycol)-alpha,omega-bispropionic acid

CAS-No. 2152679-62-2

Formula C 34H 61NO 19 Mol. weight 787,84 g/mol

PEG3980 NHS-PEG(13)-NHS

alpha,omega-bis(succinimidyl propionate) dodeca(ethylene glycol)

CAS-No. 1008402-79-6

Formula C 38 H 64N2O 21 Mol. weight 884,92 g/mol

PEG3990 NHS-PEG(17)-NHS

alpha,omega-bis(succinimidyl propionate) hexadeca(ethylene glycol)

CAS-No. 1008402-79-6

Formula C 46 H 80 N2O 25 Mol. weight 1061,13 g/mol

PEG4000 NHS-PEG(21)-NHS

alpha,omega-bis(succinimidyl propionate) 20(ethylene glycol)

CAS-No. 1008402-79-6

Formula C 54H96 N2O 29 Mol. weight 1237,34 g/mol

PEG7720 NHS-PEG(25)-COOH

alpha-succinimidyl 25(ethylen glycol)-alpha,omega-bispropionic acid

CAS-No. 2563872-17-1

Formula C 58 H109 NO 31 Mol. weight 1316,47 g/mol

PEG4010 NHS-PEG(25)-NHS

alpha,omega-bis(succinimidyl propionate) 24(ethylene glycol)

CAS-No. 1008402-79-6

Formula C 62H112N2O 33

Mol. weight 1413,55 g/mol

PEG4110

Tfp-PEG(25)-Tfp

alpha,omega-Bis(2,3,4,5-tetrafluorphenyl propionate) 25(ethylene glycol)

Formula C 66 H106 F8 O 29 Mol. weight 1515,52 g/mol

PEG1083

HOOC-PEG-COOH (2 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

Mol. weight 2000 Da

PEG1085

HOOC-PEG-COOH (3 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

Mol. weight 3000 Da

PEG1086

HOOC-PEG-COOH (6 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

Mol. weight 6000 Da

PEG1082

HOOC-PEG-COOH (10 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

Mol. weight 10000 Da

PEGylation

PEG1084

HOOC-PEG-COOH (20 kDa)

alpha,omega-Bis-carboxy poly(ethylene glycol)

Mol. weight 20000 Da

PEG1184

NHS-PEG-NHS (2 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

CAS-No. 186020-53-1 Mol. weight 2000 Da

PEG1186

NHS-PEG-NHS (3 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

CAS-No. 186020-53-1 Mol. weight 3000 Da

PEG1187

NHS-PEG-NHS (6 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

CAS-No. 186020-53-1 Mol. weight 6000 Da

PEG1183

NHS-PEG-NHS (10 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

CAS-No. 186020-53-1 Mol. weight 10000 Da

PEG1185

NHS-PEG-NHS (20 kDa)

alpha,omega-Di-succinimidyl ester poly(ethylene glycol)

CAS-No. 186020-53-1 Mol. weight 20000 Da

3.3. Methoxy-PEG and other Alkyl-PEG-Acids & -Esters

PEG1630 MeO-EPr-COOH

3-(2-Methoxyethoxy)propanoic acid, 4,7-Dioxa-octanoic acid

CAS-No. 149577-05-9

Formula C 6 H12O4 Mol. weight 148,16 g/mol

PEG1905 MeO-EPr-NHS

3-(2-Methoxyethoxy)propanoic acid succinimidyl ester

CAS-No. 1127247-34-0

Formula C10 H15NO 6 Mol. weight 245,23 g/mol

PEG4990 Palm-AEEA

{2-[2-(Palmitoyl-amino)ethoxy]ethoxy}acetic acid

CAS-No. 1570043-00-3

Formula C 22H43 NO 5 Mol. weight 401,58 g/mol

PEG1203 Stea-O2Oc-OH

8-(Stearoylamido)-3,6-dioxaoctanoic acid

CAS-No. 1006054-22-3

Formula C 24H47NO 5

Mol. weight 429,65 g/mol

PEG1620 MeO-PEG(3)-COOH

2,5,8,11-Tetraoxatetradecan-14-oic acid

CAS-No. 67319-28-2

Formula C10 H20 O 6

Mol. weight 236,26 g/mol

PEGylation

PEG1880

MeO-PEG(3)-NHS

2,5,8,11-Tetraoxatetradecan-14-oic acid succinimidyl ester

CAS-No. 174569-25-6

Formula C14H23 NO 8 Mol. weight 333,33 g/mol

PEG1625

MeO-PEG(8)-COOH

2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid

CAS-No. 1093647-41-6

Formula C18 H36 O 10 Mol. weight 412,47 g/mol

PEG1885

MeO-PEG(8)-NHS

2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid succinimidyl ester

CAS-No. 756525-90-3

Formula C 22H39 NO 12 Mol. weight 509,54 g/mol

PEG1156

MeO-PEG(12)-COOH

2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaoctatriacontan-38-oic acid

CAS-No. 2135793-73-4

Formula C 26 H 52O 14 Mol. weight 588,68 g/mol

PEG6875

MeO-PEG(12)-Amido-PEG(12)-COOH

38-oxo-2,5,8,11,14,17,20,23,26,29,32,35,42,45,48,51,54,57,60,63,66,69,72,75-tetracosaoxa-39-azaoctaheptacontan-78-oic acid

Formula C 53 H105NO 27 Mol. weight 1188,40 g/mol

PEG1890

MeO-PEG(12)-NHS

2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaoctatriacontan-38-oic acid succinimidyl ester

CAS-No. 2207596-93-6

Formula C 30 H 55NO 16 Mol. weight 685,75 g/mol

PEG7420

MeO-PEG(12)-TFP

2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaoctatriacontan-38-oic acid 2,3,5,6-tetrafluorophenyl ester

Formula C 224H422N10 O 109 Mol. weight 736,74 g/mol

PEG6885

MeO-PEG(12)-amido-PEG(12)-TFP

2,3,5,6-tetrafluorophenyl 38-oxo-2,5,8,11,14,17,20,23,26,29,32,35,42,45,48,51,54,57,60,63,66,69,72,75-tetracosaoxa-39-azaoctaheptacontan-78-oate

Formula C 59 H105F4NO 27 Mol. weight 1336,46 g/mol

PEG6945

MeO-PEG(13)-COOH

2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxahentetracontan-41-oic acid

CAS-No. 2170098-33-4

Formula C 28 H 56 O 15 Mol. weight 632,74 g/mol

PEG6955

MeO-PEG(13)-NHS

2,5-dioxopyrrolidin-1-yl

2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxahentetracontan-41-oate

Formula C 32H 59 NO 17 Mol. weight 729,81 g/mol

PEG6965 MeO-PEG(13)-TFP

2,3,5,6-tetrafluorophenyl

2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxahentetracontan-41-oate

Formula C 34H 56 F4O 15

Mol. weight 780,80 g/mol

PEG7430 MeO-PEG(24)-TFP

alpha-Methoxy-23(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

Formula C 56 H100 F4O 26

Mol. weight 1265,37 g/mol

PEGylation

PEG1640

MeO-PEG(25)-COOH

alpha-Methoxy-24(ethylen glycol)-omega-propionic acid

CAS-No. 125220-94-2

Formula C 52H104O 27 Mol. weight 1161,38 g/mol

PEG1902

MeO-PEG(25)-NHS

alpha-Methoxy-24(ethylene glycol)-omega-propionic acid succinimidyl ester

CAS-No. 174569-25-6

Formula C 56 H107NO 29 Mol. weight 1258,44 g/mol

PEG7440

MeO-PEG(25)-TFP

alpha-Methoxy-24(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

Formula C 58 H104F4O 27 Mol. weight 1309,42 g/mol

PEG5030 TFP-PEG(4)-[mPEG(11)] 3

Tetrafluorphenyl carboxylate-PEG(4)-[PEG(10)-OMe] 3

Formula C104H191F4N 5 O47 Mol. weight 2339,63 g/mol

PEG3210 MeO-PEG(37)-COOH

alpha-Methoxy-37(ethylene glycol)-omega-propionic acid

CAS-No. 2924199-92-6

Formula C 76 H152O 39 Mol. weight 1690 g/mol

PEG3190

MeO-PEG(37)-NHS

alpha-Methoxy-37(ethylene glycol)-omega-propionic acid succinimidyl ester

CAS-No. 174569-25-6

Formula C 80 H155NO41 Mol. weight 1786,07 g/mol

PEG3221

MeO-PEG(48)-COOH

alpha-Methoxy-48(ethylene glycol)-omega-propionic acid

Formula C102H203 NO 51 Mol. weight 2259,68 g/mol

PEG6865

MeO-PEG(48)-NH-CO(CH2)3CO-TFP

2,3,5,6-tetrafluorophenyl148-oxo- 2,5,8,11,14,17,20,23,26, 29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,8 6,89,92,95,98,101,104,107,110,113,116,119,122,125,128,131,134 ,137,140,143-octatetra contaoxa-146-azahenpentacontahectan-151-oate

Formula C108 H203 F4NO 51 Mol. weight 2407,76 g/mol

PEG7015

MeO-PEG(25)-amido-PEG(24)-COOH

77-oxo- 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53, 56,59,62,65,68,71,74,81,84,87,90,93,96,99,102,105,108,111,1 14,117,120,123,126,129,132,135,138,141,144,147,150-nonatetracontaoxa-78-azatripen tacontahectan-153-oic acid

Formula C103 H205NO 52 Mol. weight 2289,73 g/mol

PEG7005

MeO-PEG(25)-amido-PEG(24)-TFP

2,3,5,6-tetrafluorophenyl77-oxo- 2,5,8,11,14,17,20,23,26,2 9,32,35,38,41,44,47,50,53,56,59,62,6568,71,74,81,84,87,90, 93,96,99,102,105,108,111,114,117,120,123,126,129,132,135,138 ,141,144,147,150-nonate tracontaoxa-78-azatripentacontahectan-153-oate

Formula C109 H205F4NO 52 Mol. weight 2437,79 g/mol

PEG1161

MeO-PEG-COOH (750 Da)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2 Mol. weight 750 Da

PEGylation

PEG1158

MeO-PEG-COOH (2 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2 Mol. weight 2000 Da

PEG1160

MeO-PEG-COOH (5 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2 Mol. weight 5000 Da

PEG1157

MeO-PEG-COOH (10 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2 Mol. weight 10000 Da

PEG1159

MeO-PEG-COOH (20 kDa)

alpha-Methoxy-omega-carboxylic acid poly(ethylene glycol)

CAS-No. 92450-99-2 Mol. weight 20000 Da

PEG1166

MeO-PEG-NHS (750 Da)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

CAS-No. 92451-00-8 Mol. weight 750 Da

PEG1163

MeO-PEG-NHS (2 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

CAS-No. 92451-00-8 Mol. weight 2000 Da

PEG1165

MeO-PEG-NHS (5 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

CAS-No. 92451-00-8

Mol. weight 5000 Da

PEG1162

MeO-PEG-NHS (10 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

CAS-No. 92451-00-8 Mol. weight 10000 Da

PEG1164

MeO-PEG-NHS (20 kDa)

alpha-Methoxy-omega-carboxylic acid succinimidyl ester poly(ethylene glycol)

CAS-No. 92451-00-8 Mol. weight 20000 Da

PEG6640

MeO-PEG-SQA (750 Da)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1334217-01-4 Mol. weight 750 Da

PEG6625

MeO-PEG-SQA (2 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1334217-01-4 Mol. weight 2000 Da

PEG6635

MeO-PEG-SQA (5 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1334217-01-4 Mol. weight 5000 Da

PEGylation

PEG6620

MeO-PEG-SQA (10 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1334217-01-4 Mol. weight 10000 Da

PEG6630

MeO-PEG-SQA (20 kDa)

alpha-Methoxy-omega-squaric acid ethyl ester poly(ethylene glycol)

CAS-No. 1334217-01-4 Mol. weight 20000 Da

3.4. PEG-Acids & -Esters with other Terminal Functionalities

PEG7610

Bromoacetamido-PEG(4)-TFP

Bromoacetamido-tetra(ethylene glycol)-propionic acid

2,3,5,6-tetrafluorophenyl ester

CAS-No. 2247993-78-6

Formula C19 H24BrF4NO 7 Mol. weight 534,29 g/mol

PEG7620

Bromoacetamido-PEG(12)-TFP

Bromoacetamido-dodeca(ethylene glycol)-propionic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 2854365-65-2

Formula C 35H 56 BrF4NO 15 Mol. weight 886,71 g/mol

PEG7630

Bromoacetamido-PEG(24)-TFP

Bromoacetamido-24(ethylene glycol)-propionic acid

2,3,5,6-tetrafluorophenyl ester

Formula C 59 H104BrF4NO 27 Mol. weight 1415,35 g/mol

Product details

PEG6980 DOTA-PEG(3)-bromoacetamide*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-tri(ethylene glycol)-omega-maleimido bistrifluoroacetate

CAS-No. 2389064-48-4 net

Formula C 26 H47BrN 6 O 11*2CF 3 CO 2H Mol. weight 699,59*228,05 g/mol

PEG6990 DOTA-PEG(11)-bromoacetamide*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-undeca(ethylene glycol)-omega-maleimido bistrifluoroacetate

Formula C 42H79 BrN 6 O 19*2CF 3 CO 2H Mol. weight 1052,01*228,05 g/mol

PEG7025 DOTA tris(TBE)-amido-PEG(23)-bromoacetamide

Formula C 78 H151BrN 6 O 31 Mol. weight 1748,98 g/mol

PEG5080 Phth-NO-PEG(4)-NHS

1-Phthalimidoxy-3,6,9,12-tetraoxapentadecan-15-oic acid succinimdyl ester

CAS-No. 1415328-95-8

Formula C 23 H28 N2O 11 Mol. weight 508,48 g/mol

PEG4630 Phth-NO-PEG(12)-NHS

alpha-Pthaloylaminoxy-omega-(succinimidyl propionate)-dodeca(ethylene glycol)

Formula C 39 H 60 N2O 19 Mol. weight 860,90 g/mol

PEG4690 FB-PEG(12)-TFP

alpha-( p-Formylbenzoylamido)-omega-[(2,3,5,6-tetrafluorophenyl)propionate]-dodeca(ethylene glycol)

Formula C 41H 59 F4NO 16 Mol. weight 897,90 g/mol

PEGylation

RL-4040 PFB-mercaptopropionyl-AEEA

Perfluorobiphenyl-mercaptopropionyl-AEEA

Formula C 21H16 F9 NO 5 S Mol. weight 565,41 g/mol

PEG6845 NHS-PEG(13)-DSPE

(2R)-3-((((46-((2,5-dioxopyrrolidin-1-yl)oxy)-4,46-dioxo -7,10,13,16,19,22,25,28,31,34,37,40,43-tridecaoxa-3-azahexatetracontyl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyldistearate

Formula C 75H141N2O 26 P Mol. weight 1517,91 g/mol

PEG7045 Cbz-amido-PEG(24)-amido-PEG(24)-COOH

3,79-dioxo-1-phenyl- 2,7,10,13,16,19,22,25,28,31,34,37 ,40,43,46,49,52,55,58,61,64,67,70,73,76,83,86,89,92,9 5,98,101,104,107,110,113,116,119,122,125,128,131,134,137, 140,143,146,149,152-nonatetracontao xa-4-80-diazapentapentacontahectan-155-oic acid

Formula C110 H210 N2O 53 Mol. weight 2408,85 g/mol

PEG6880 DOTA-PEG(4)-TFP*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-tetra(ethylene glycol)-omega-(2,3,5,6-tetrafluorophenyl propionate) bistrifluoroacetate

CAS-No. 2389064-50-8 net

Formula C 33 H49 F4N 5 O 13*2CF 3 CO 2H Mol. weight 799,76*228,05 g/mol

4. PEG-Amines, -Hydrazines and -Guanidines

4.1. Mono-Protected PEG-Diamines

BNN1016 Boc-DOOA

1-(t-Butyloxycarbonyl-amino)-3,6-dioxa-8-octaneamine, liq.

CAS-No. 153086-78-3

Formula C11H24N2O4 Mol. weight 248,32 g/mol

BNN1015 Boc-DODA

1-(t-Butyloxycarbonyl-amino)-4,9-dioxa-12-dodecanamine, liq.

CAS-No. 101187-29-5

Formula C15H32N2O4 Mol. weight 304,43 g/mol

BNN1028 Boc-TOTA

1-(t-Butyloxycarbonyl-amino)-4,7,10-trioxa-13-tridecanamine, liq.

CAS-No. 194920-62-2

Formula C15H32N2O 5 Mol. weight 320,43 g/mol

PEG7870 Boc-NH-PEG(3)-NH2

1-(t-Butyloxycarbonyl)amino-3,6,9-trioxa-undecan-11amine

CAS-No. 101187-40-0

Formula C13 H28 N2O 5 Mol. weight 292,37 g/mol

PEG6835 Boc-NH-PEG(3)-NH2*HCl

tert-butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy) ethyl)carbamate

CAS-No. 101187-40-0 net

Formula C13 H28 N2O 5*HCl Mol. weight 292,38*36,46 g/mol

PEGylation

PEG7880 Boc-NH-PEG(4)-NH2

1-(t-Butyloxycarbonyl)amino-3,6,9,12-tetraoxatetradecan-14-amine

CAS-No. 811442-84-9

Formula C15H32N2O 6 Mol. weight 336,42 g/mol

PEG7890 Boc-NH-PEG(5)-NH2

1-(t-Butyloxycarbonyl)amino-3,6,9,12,15-pentaoxaheptadecan-17-amine

CAS-No. 189209-27-6

Formula C17H36 N2O 7 Mol. weight 380,48 g/mol

PEG1066 Boc-NH-PEG(7)-NH2

alpha-Amino-omega-Boc-amino-hepta(ethylene glycol)

CAS-No. 206265-98-7

Formula C 21H44N2O 9 Mol. weight 468,59 g/mol

PEG1065 Boc-NH-PEG(11)-NH2

alpha-Amino-omega-Boc-amino-undecae(ethylene glycol)

CAS-No. 198227-38-2

Formula C 29 H 60 N2O 13 Mol. weight 644,81 g/mol

PEG4660 Amino-PEG(11)-aminoxy-Boc

alpha-Amino-omega-(t-butyloxycarbonyl-aminoxy)-undeca(ethylene glycol)

Formula C 29 H 60 N2O 14 Mol. weight 660,79 g/mol

PEG7690 Boc-NH-PEG(23)-NH2

alpha-Amino-omega-Boc-amino-23(ethylene glycol)

Formula C 53 H108 N2O 25 Mol. weight 1173,42 g/mol

PEG1068

Boc-NH-PEG-NH2 (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol)

Mol. weight 3000 Da

PEG1069

Boc-NH-PEG-NH2 (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol)

Mol. weight 5000 Da

PEG1067

Boc-NH-PEG-NH2 (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol)

Mol. weight 10000 Da

PEG1335 H2 N-PEG(4)-NHNH-Boc

15-Amino-4,7,10,13-tetraoxa-pentadecanoyl-N‘-(t-butyloxycarbonyl)-hydrazid

CAS-No. 1263047-17-1

Formula C16 H33 N3 O 7

Mol. weight 379,45 g/mol

PEG4230 H2 N-PEG(8)-NHNH-Boc

alpha-Amino-omega-(N‘-(t-butyloxycarbonyl)hydrazido propionate) octa(ethylene glycol)

CAS-No. 1334169-96-8

Formula C 24H49 N3 O 11 Mol. weight 555,66 g/mol

PEG4240 H2 N-PEG(12)-NHNH-Boc

alpha-Amino-omega-(N‘-(t-butyloxycarbonyl)hydrazido propionate) dodeca(ethylene glycol)

CAS-No. 1334169-97-9

Formula C 32H 65N3 O 15

Mol. weight 731,87 g/mol

PEGylation

PEG1805 Fmoc-NH-PEG(4)-NHNH-Boc

15-(9-Fluorenylmethyloxycarbonyl)amino-4,7,10,13-tetraoxa-pentadecanoyl-N‘-(t-butyloxycarbonyl)hydrazid

CAS-No. 1263044-77-4

Formula C 31H43 N3 O 9 Mol. weight 601,69 g/mol

FNN1008 Fmoc-EDA*HCl

N1-(9-Fluorenylmethyloxycarbonyl)-ethylenediamine hydrochloride

CAS-No. 391624-46-7

Formula C17H18 N2O 2*HCl Mol. weight 318,8 g/mol

FNN1007 Fmoc-DOOA*HCl

1-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxa-8-octaneamine hydrochloride

CAS-No. 868599-73-9

Formula C 21H26 N2O4*HCl Mol. weight 370,45*36,45 g/mol

FNN1006 Fmoc-DODA*HCl

1-(9-Fluorenylmethyloxycarbonyl-amino)-4,9-dioxa-12-dodecanamine hydrochloride

CAS-No. 1274891-99-4

Formula C 25H34N2O4*HCl Mol. weight 426,56*36,45 g/mol

FNN1011 Fmoc-TOTA*HCl

1-(9-Fluorenylmethyloxycarbonyl-amino)-4,7,10-trioxa-13-tridecanamine hydrochloride

CAS-No. 868599-75-1

Formula C 25H34N2O 5*HCl Mol. weight 442,56*36,45 g/mol

RL-4390 Fmoc-NH-PEG(3)-NH2*HCl

(9H-fluoren-9-yl)methyl (2-(2-(2-(2-aminoethoxy) ethoxy)ethoxy)ethyl)carbamate hydrochloride H2N

CAS-No. 906079-91-2

Formula C 23 H30 N2O 5*HCl Mol. weight 414,50*36,45 g/mol

ZNN1120 Z-TOTA

1-Benzyloxycarbonyl-4,7,10-trioxa-13-tridecaneamine

CAS-No. 220156-99-0

Formula C18 H30 N2O 5 Mol. weight 354,45 g/mol

4.2. Unprotected PEG-Diamines

PEG1204 H2 N-PEG(7)-NH2

alpha,omega-Bis-amino octa(ethylene glycol)

CAS-No. 332941-25-0

Formula C16 H36 N2O 7 Mol. weight 368,47 g/mol

PEG1500 H2 N-PEG(11)-NH2

N1,N19-bis(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy) propyl)-4,7,10,13,16-pentaoxanonadecane-1,19-diamide

CAS-No. 1224728-09-9

Formula C 34H70 N4O 13 Mol. weight 742,94 g/mol

PEG2001 H2 N-PEG(27)-NH2

alpha,omega-Bis-amino 27(ethylene glycol)

CAS-No. 24991-53-5

Formula C 56 H116 N2O 27 Mol. weight 1249,52 g/mol

PEG1002 H2 N-PEG-NH2 (2 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5 Mol. weight 2000 Da

PEGylation

Product details

PEG1004 H2 N-PEG-NH2 (3 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 3000 Da

PEG1005 H2 N-PEG-NH2 (6 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 6000 Da

PEG1001 H2 N-PEG-NH2 (10 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5 Mol. weight 10000 Da

PEG1003 H2 N-PEG-NH2 (20 kDa)

alpha,omega-Bis-amino poly(ethylene glycol)

CAS-No. 24991-53-5

Mol. weight 20000 Da

4.3. (Protected) Amino-PEG-Alcohols

PEG1320 H2 N-PEG(4)-OH

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol

CAS-No. 86770-74-3

Formula C 8 H19 NO4

Mol. weight 193,24 g/mol

Product details

PEG1340 H2 N-PEG(8)-OH

23-Amino-3,6,9,12,15,18,21-heptaoxatrieicosane-1-ol

CAS-No. 352439-37-3

Formula C16 H35NO 8 Mol. weight 369,45 g/mol

PEG1310 H2 N-PEG(12)-OH

35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol

CAS-No. 933789-97-0

Formula C 24H 51NO 12 Mol. weight 545,66 g/mol

PEG3740 H2 N-PEG(24)-OH

alpha-Amino-omega-hydroxy 24(ethylene glycol) H2N O

CAS-No. 933789-97-0

Formula C 48 H99 NO 24 Mol. weight 1074,29 g/mol

PEG3750 H2 N-PEG(36)-OH

alpha-Amino-omega-hydroxy 36(ethylene glycol)

CAS-No. 933789-97-0

Formula C 72H147NO 36 Mol. weight 1602,92 g/mol

PEG1007 H2 N-PEG-OH (3 kDa)

alpha-Amino-omega-hydroxy poly(ethylene glycol)

CAS-No. 32130-27-1 Mol. weight 3000 Da

PEG1008 H2 N-PEG-OH (5 kDa)

alpha-Amino-omega-hydroxy poly(ethylene glycol)

CAS-No. 32130-27-1 Mol. weight 5000 Da

PEGylation

PEG1006 H2 N-PEG-OH (10 kDa)

alpha-Amino-omega-hydroxy poly(ethylene glycol)

CAS-No. 32130-27-1 Mol. weight 10000 Da

PEG1915 Boc-NH-PEG(4)-OH

2-(2-(2-(2-(t-Butyloxycarbonylamino)ethoxy)ethoxy) ethoxy)ethanol

CAS-No. 106984-09-2

Formula C13 H27NO 6 Mol. weight 293,36 g/mol

PEG7860 Boc2-AEEEE

2-(2-(2-(2-(Di-(t-butylmethyloxycarbonyl))aminoethoxy) ethoxy)ethoxy)ethanol

CAS-No. 2389064-37-1

Formula C18 H35NO 8 Mol. weight 393,47 g/mol

PEG5385 Boc,Z-AEEEE

2-(2-(2-(2-(Benzyloxycarbonyl-tert-Butylmethyloxycarbonyl)aminoethoxy)ethoxy)ethoxy)ethanol

CAS-No. 2389064-46-2

Formula C 21H33 NO 8 Mol. weight 427,49 g/mol

PEG1960 Boc-NH-PEG(12)-OH

35-(t-Butyloxycarbonylamino)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol

CAS-No. 159156-95-3

Formula C 29 H 59 NO 14 Mol. weight 645,78 g/mol

PEG1021 Boc-NH-PEG-OH (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-hydroxy poly(ethylene glycol)

CAS-No. 159156-95-3 Mol. weight 3000 Da

PEG1022

Boc-NH-PEG-OH (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-hydroxy poly(ethylene glycol)

CAS-No. 159156-95-3

Mol. weight 5000 Da

PEG1020

Boc-NH-PEG-OH (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-hydroxy poly(ethylene glycol)

CAS-No. 159156-95-3 Mol. weight 10000 Da

PEG1030 HO-PEG-CONH-NH-Boc (3 kDa)

alpha-Hydroxy-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 3000 Da

PEG1031

HO-PEG-CONH-NH-Boc (5 kDa)

alpha-Hydroxy-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 5000 Da

PEG1029 HO-PEG-CONH-NH-Boc (10 kDa)

alpha-Hydroxy-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 10000 Da

FAL3010 Fmoc-O1Pen-ol

5-(9-Fluorenylmethyloxycarbonyl-amino)-3-oxa-1-pentanol

CAS-No. 299430-87-8

Formula C19 H21NO4

Mol. weight 327,37 g/mol

PEGylation

PEG5370 Fmoc-AEEE

2-(2-(2-(9-Fluorenylmethyloxycarbonyl)aminoethoxy) ethoxy)ethanol

CAS-No. 560088-66-6

Formula C 21H25NO 5 Mol. weight 371,43 g/mol

PEG5380 Fmoc-AEEEE

2-(2-(2-(2-(9-Fluorenylmethyloxycarbonyl)aminoethoxy)ethoxy)ethoxy)ethanol

CAS-No. 868594-41-6

Formula C 23 H29 NO 6 Mol. weight 415,48 g/mol

4.4. Methoxy-PEG-Amines

PEG1685 MeO-PEG(4)-NH2

2,5,8,11-Tetraoxatridecan-13-amine

CAS-No. 85030-56-4

Formula C9 H21NO4

Mol. weight 207,27 g/mol

Product details

PEG1730

MeO-PEG(7)-NH2

2,5,8,11,14,17,20-heptaoxadocosan-22-amine

CAS-No. 170572-38-0

Formula C15H33 NO 7 Mol. weight 339,43 g/mol

PEG1700

MeO-PEG(8)-NH2

2,5,8,11,14,17,20,23-Octaoxapentacosan-25-amine

CAS-No. 869718-81-0

Formula C17H37NO 8

Mol. weight 383,48 g/mol

PEG1655

MeO-PEG(12)-NH2

2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatriacontan-37-amine

CAS-No. 32130-27-1

Formula C 25H 53 NO 12

Mol. weight 559,69 g/mol

PEG3290 MeO-PEG(15)-NH2

alpha-Methoxy-omega-amino-15(ethylene glycol)

CAS-No. 32130-27-1

Formula C 31H 65NO 15 Mol. weight 691,85 g/mol

PEG1670

MeO-PEG(24)-NH2

alpha-Methoxy-omega-amino-24(ethylene glycol)

CAS-No. 32130-27-1

Formula C 49 H101NO 24 Mol. weight 1088,34 g/mol

PEG3300 MeO-PEG(36)-NH2

alpha-Methoxy-omega-amino-36(ethylene glycol)

CAS-No. 32130-27-1

Formula C 73 H149 NO 36 Mol. weight 1616,95 g/mol

PEG3310

MeO-PEG(48)-NH2

alpha-Methoxy-omega-amino-48(ethylene glycol)

CAS-No. 32130-27-1

Formula C97H197NO48 Mol. weight 2145,58 g/mol

PEG1155 MeO-PEG-NH2 (750 Da)

alpha-Methoxy-omega-amino poly(ethylene glycol)

Mol. weight 750 Da

PEGylation

PEG1152

MeO-PEG-NH2 (2 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

Mol. weight 2000 Da

PEG1154

MeO-PEG-NH2 (5 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

Mol. weight 5000 Da

PEG1151

MeO-PEG-NH2 (10 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

Mol. weight 10000 Da

PEG1153

MeO-PEG-NH2 (20 kDa)

alpha-Methoxy-omega-amino poly(ethylene glycol)

Mol. weight 20000 Da

5. PEGs Functionalized for Click Chemistry

5.1. PEG-Alkynes

PEG5430 Alkyne-PEG(4)-NH2

Alkyne-PEG(4)-amine

CAS-No. 1013921-36-2

Formula C11H21NO4

Mol. weight 231,29 g/mol

PEG2960 H2 N-PEG-alkyne (3 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 3000 Da

PEG2980 H2 N-PEG-alkyne (5 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 5000 Da

PEG2950 H2 N-PEG-alkyne (10 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 10000 Da

PEG2970 H2 N-PEG-alkyne (20 kDa)

alpha-Amino-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 20000 Da

PEGylation

PAA1050 Poc-O2Oc-OH*DCHA

8-(Popargylyloxycarbonyl-amino)-3,6-dioxaoctanoic acid dicyclohexylamine

CAS-No. 2988660-57-5

Formula C10 H15NO 6*C12H23 N

Mol. weight 245,23*181,32 g/mol

PEG5410 Alkyne-PEG(4)-NHS

Alkyne-PEG(4)-succinimidyl ester

CAS-No. 1393330-40-9

Formula C18 H27NO 9 Mol. weight 401,41 g/mol

PEG5440 Alkyne-PEG(4)-mal

Alkyne-PEG(4)-maleimide

CAS-No. 1609651-90-2

Formula C18 H26 N2O 7 Mol. weight 382,41 g/mol

RL-8630 Alkyne-PEG(4)-CINA

2-cyano-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl) isonicotinamide

Formula C18 H23 N3 O 5 Mol. weight 361,40 g/mol

PEG6815 Alkyne-O2Oc-OH

Pentynoyl-8-amino-3,6-dioxaoctanoic acid

CAS-No. 2134622-80-1

Formula C11H17NO 5 Mol. weight 243,26 g/mol

PEG8170 Propargyl-PEG(5)-COOH

4,7,10,13,16-pentaoxanonadec-18-ynoic acid

CAS-No. 1245823-51-1

Formula C14H24O 7 Mol. weight 304,34 g/mol

PEG2860 NHS-PEG-alkyne (3 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 3000 Da

PEG2880 NHS-PEG-alkyne (5 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 5000 Da

PEG2850 NHS-PEG-alkyne (10 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 10000 Da

PEG2870 NHS-PEG-alkyne (20 kDa)

alpha-Succinimidyl ester-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 20000 Da

PEG6570 Alkynyl-PEG-SQA (3 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG6575

Alkynyl-PEG-SQA (5 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEGylation

PEG6560 Alkynyl-PEG-SQA (10 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6565

Alkynyl-PEG-SQA (20 kDa)

alpha-Pentynyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG4950

Biotin-PEG(4)-alkyne

15-[D(+)-Biotinylamino]-4,7,10,13-tetraoxapentadec-1-yne

CAS-No. 1262681-31-1

Formula C 21H35N3 O 6 S Mol. weight 457,58 g/mol

PEG6805

Biotin-PEG3-NH-Pentynoyl

alpha-Biotin-omega-pentynoyl 3(ethylene glycol)

CAS-No. 869082-82-6

Formula C 23 H38 N4O 6 S Mol. weight 498,64 g/mol

PEG8010

Biotin-PEG(4)-Alkyne

(3aS,4S,6aR)-4-(5,21-dioxo-8,11,14,17-tetraoxa-4,20diazapentacos-1-yn-25-yl)tetrahydro-1H-thieno[3,4-d] imidazol-2(3H)-one

CAS-No. 1006592-45-5

Formula C 24H40 N4O 7S Mol. weight 528,66 g/mol

PEG8110

Biotin-PEG(4)-SS-Alkyne

N-(2-((3-oxo-3-(prop-2-ynylamino)propyl)disulfanyl)ethyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide

CAS-No. 1260247-54-8

Formula C 29 H49 N 5 O 8 S 3 Mol. weight 691,92 g/mol

PEG7980 Biotin-PEG(4)-Dde-Alkyne

N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12tetraoxa-16-azanonadec-18-ynyl)-5-((3aS,4S,6aR)-2oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1802908-00-4

Formula C 32H 50 N4O 8 S

Mol. weight 650,83 g/mol

PEG3110 I-PEG-alkyne (3 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 3000 Da

PEG3120 I-PEG-alkyne (5 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 5000 Da

PEG3090 I-PEG-alkyne (10 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 10000 Da

PEG3100 I-PEG-alkyne (20 kDa)

alpha-Iodo-omega-propargylacetamido poly(ethylene glycol)

Mol. weight 20000 Da

PEG2840 MeO-PEG-alkyne (750 Da)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

CAS-No. 1993176-75-2

Mol. weight 750 Da

PEGylation

PEG2810

MeO-PEG-alkyne (2 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

CAS-No. 850180-69-7

Mol. weight 2000 Da

PEG2830

MeO-PEG-alkyne (5 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

CAS-No. 850180-69-7 Mol. weight 5000 Da

PEG2800

MeO-PEG-alkyne (10 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

CAS-No. 850180-69-7 Mol. weight 10000 Da

PEG2820

MeO-PEG-alkyne (20 kDa)

alpha-Methoxy-omega-propargylacetamido poly(ethylene glycol)

CAS-No. 850180-69-7 Mol. weight 20000 Da

PEG4810

Alkyne-PEG-Si(OMe)3 (3 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 3000 Da

PEG4815

Alkyne-PEG-Si(OMe)3 (5 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 5000 Da

PEG4820 Alkyne-PEG-Si(OMe)3 (10 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 10000 Da

PEG4825 Alkyne-PEG-Si(OMe)3 (20 kDa)

alpha-Propargylacetamido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 20000 Da

RL-3940 Alkyne-PEG(5)-SNAP

N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide

Formula C 27H36 N 6 O 7

Mol. weight 556,62 g/mol

5.2. PEG-DBCO

RL-2480 DBCO-PEG(3)-BisSulfonThiol-Linker

Dibenzoazacyclooctyne-PEG(3)-BisSulfon-Thiol-Linker

Formula C 59 H 69 N3 O 14 S 3

Mol. weight 1140,39 g/mol

PEG6740 DBCO-PEG(4)-TFP

Dibenzoazacyclooctyne-tetra(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

CAS-No. 2247993-79-7

Formula C 37H38 F4N2O 8

Mol. weight 714,7 g/mol

PEGylation

PEG6765

DBCO-PEG(36)-TFP

Dibenzoazacyclooctyne-36(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

CAS-No. 2924873-16-3

Formula C101H166 F4N2O40 Mol. weight 2124,41 g/mol

RL-2420

DBCO-PEG(4)-NH2*TFA

Dibenzoazacyclooctyne-tetra(ethylene glycol)-amine trifluoro acetic acid salt

CAS-No. 1255942-08-5

Formula C 29 H37N3 O 6*C 2F 3 HO 2 Mol. weight 523,62*114,02 g/mol

RL-2421

DBCO-Sulfo-PEG(4)-NH2

Dibenzoazacyclooctyne-tetra(ethylene glycol)amine

CAS-No. 2055198-05-3

Formula C 32H42N4O 10 S Mol. weight 674,76 g/mol

PEG6790

Bromoacetamido-PEG(4)-DBCO

Bromoacetamido-tetra(ethylene glycol)-amido-dibenzoazacyclooctyne

CAS-No. 2735663-70-2

Formula C 31H38 BrN3 O 7 Mol. weight 644,55 g/mol

RL-2520 Biotin-PEG(4)-DBCO

Dibenzoazacyclooctyne-tetra(ethylene glycol)-biotin

CAS-No. 1255942-07-4

Formula C 39 H 51N 5 O 8 S Mol. weight 749,92 g/mol

PEG8140

Biotin-PEG(4)-Dde-DBCO

N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo19-(azadibenzocyclooctyn-1-yl)-3,6,9,12-tetraoxa-16azanonadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1807512-43-1

Formula C 47H 61N 5 O 9 S Mol. weight 872,08 g/mol

PEG8120 Biotin-PEG(4)-SS-DBCO

N-(2-((3-(3-(azadibenzocyclooctyn-1-yl)-3-oxopropylamino)-3-oxopropyl)disulfanyl)ethyl)-1-(5-((3aS,4S,6aR)2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-am ide

Formula C 44H 60 N 6 O 9 S 3 Mol. weight 913,18 g/mol

RL-2500 DBCO-PEG(4)-mal

Dibenzoazacyclooctyne-tetra(ethylene glycol)-maleimide

CAS-No. 1480516-75-3

Formula C 36 H42N4O 9 Mol. weight 674,74 g/mol

RL-2510 DBCO-PEG(4)-OH

Dibenzoazacyclooctyne-tetra(ethylene glycol)

CAS-No. 1416711-60-8

Formula C 29 H36 N2O 6 Mol. weight 508,61 g/mol

RL-2450 DBCO-PEG(5)-COOH

Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid

CAS-No. 1870899-46-9

Formula C 32H40 N2O 9 Mol. weight 596,67 g/mol

RL-2460

DBCO-PEG(5)-NHS

Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid succinimidyl ester

CAS-No. 1378531-80-6

Formula C 36 H43 N3 O 11 Mol. weight 693,74 g/mol

PEG6800

Bromoacetamido-PEG(12)-DBCO

Bromoacetamido-dodeca(ethylene glycol)-amido-dibenzoazacyclooctyne

CAS-No. 2852742-40-4

Formula C 47H70 BrN3 O 17 Mol. weight 996,97 g/mol

PEGylation

PEG7465 Me-PEG(12)-DBCO

Methyl-12(ethylene glycol)-amido-dibenzoazacyclooctyne

Formula C 45H 68 N2O 14 Mol. weight 861,04 g/mol

PEG6770 DBCO-PEG(12)-MAL

Dibenzoazacyclooctyne-dodeca(ethylene glycol)-maleimide

CAS-No. 2011777-01-6

Formula C 52H74N4O 17 Mol. weight 1027,16 g/mol

PEG6750 DBCO-PEG(12)-TFP

Dibenzoazacyclooctyne-dodeca(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

CAS-No. 3038549-18-4

Formula C 53 H70 F4N2O 16 Mol. weight 1067,12 g/mol

PEG6810 Bromoacetamido-PEG(24)-DBCO

Bromoacetamido-24(ethylene glycol)-amido-dibenzoazacyclooctyne

CAS-No. 2852742-74-4

Formula C 71H118 BrN3 O 27 Mol. weight 1525,6 g/mol

PEG6780 DBCO-PEG(24)-MAL

Dibenzoazacyclooctyne-24(ethylene glycol)-maleimide

CAS-No. 2924872-84-2

Formula C 76 H122N4O 29 Mol. weight 1555,79 g/mol

PEG6760 DBCO-PEG(24)-TFP

Dibenzoazacyclooctyne-24(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

CAS-No. 2754372-40-0

Formula C 77H118 F4N2O 28 Mol. weight 1595,75 g/mol

PEG6765 DBCO-PEG(36)-TFP

Dibenzoazacyclooctyne-36(ethylene glycol)-propionyl 2,3,5,6-tetrafluorophenol ester

CAS-No. 2924873-16-3

Formula C101H166 F4N2O40 Mol. weight 2124,41 g/mol

PEG6830 DBCO-PEG(12)-(5)6-carboxyfluorescein

Dibenzoazacyclooctyne-dodeca(ethylene glycol)-(5)6-carboxyfluorescein

Formula C 46 H39 N3 O 10 Mol. weight 1234,34 g/mol

PEG7460 DBCO-PEG(24)-OMe

alpha-Methoxy-24(ethylene glycol)-amido-dibenzoazacyclooctyne

CAS-No. 3023098-71-4

Formula C 68 H114N2O 26 Mol. weight 1375,63 g/mol

RL-2530 DBCO-mPEG (5kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5

Mol. weight 5000 Da

RL-2540 DBCO-mPEG (10kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5 Mol. weight 10000 Da

RL-2550 DBCO-mPEG (20kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5 Mol. weight 20000 Da

PEGylation

RL-2560 DBCO-mPEG (30kDa)

alpha-Dibenzoazacyclooctyne-omega-methoxy-poly(ethylene glycol)

CAS-No. 2262541-53-5

Mol. weight 30000 Da

PEG7070 Tetra(-PEG(11)-DBCO)pentaerythritol

Formula C193 H288 N12O 60 Mol. weight 3736,45 g/mol

PEG7075 Bis-PEG(11)-DBCO

Formula C 64H 82N4O 15 Mol. weight 1147,37 g/mol

PEG7095 DBCO-PEG(24)-amido-PEG(24)-DSPE

Formula C163 H299 N4O 60 P Mol. weight 3306,13 g/mol

RL-8640 DBCO-PEG(4)-CINA

Dibenzoazacyclooctyne-tetra(ethylene glycol)-cyanoisonicotinamide

Formula C 36 H39 N 5 O 7 Mol. weight 653,74 g/mol

5.3. PEG-Azides

PEG4980 H2 N-PEG(2)-N3*TosOH

2-[2-(2-Azidoethoxy)ethoxy]ethanaminium tosylat

CAS-No. 166388-57-4

Formula C 7H14N4O 2*C 7H 8 O 3 S Mol. weight 174,20*172,20 g/mol

PEG4960 Boc-NH-PEG(2)-N3

1-(t-Butyloxycarbonyl-amino)-3,6-dioxa-8-octaneazide

CAS-No. 950683-55-3

Formula C11H22N4O4 Mol. weight 274,32 g/mol

BAA4920 Boc-Aoa-NH-PEG3-N3

tert-butyl ((14-azido-2-oxo-6,9,12-trioxa-3-azatetradecyl)oxy)carbamate

CAS-No. 1803191-52-7

Formula C15H29 N 5 O 7 Mol. weight 391,43 g/mol

BNN1150 N3 -TOTA

1-Azido-4,7,10-trioxa-13-tridecanamine

CAS-No. 1162336-72-2

Formula C10 H22N4O 3

Mol. weight 246,31 g/mol

PEG3060 H2 N-PEG(3)-N3

1-Amino-11-azido-3,6,9-trioxaundecane

CAS-No. 134179-38-7

Formula C 8 H18 N4O 3

Mol. weight 218,25 g/mol

PEGylation

PEG8160 N3 -PEG(3)-NH-Boc

t-Butyl N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl) carbamate

CAS-No. 642091-68-7

Formula C13 H26 N4O 5 Mol. weight 318,37 g/mol

RL-4380 Fmoc-NH-PEG(3)-N3

(9H-fluoren-9-yl)methyl (2-(2-(2-(2-azidoethoxy)ethoxy) ethoxy)ethyl)carbamate

CAS-No. 1172605-58-1

Formula C 23 H28 N4O 5 Mol. weight 440,50 g/mol

PEG5320 N3 -PEG(4)-NH2

14-Azido-3,6,9,12-tetraoxatetradecan-1-amine

CAS-No. 951671-92-4

Formula C10 H22N4O4 Mol. weight 262,31 g/mol

RL-8625 N3 -PEG(4)-CINA

N-(14-azido-3,6,9,12-tetraoxatetradecyl)-2-cyanoisonicotinamide

Formula C17H24N 6 O 5 Mol. weight 392,42 g/mol

PEG1087 H2 N-PEG(6)-N3

alpha-Amino-omega-azido hexa(ethylene glycol)

CAS-No. 957486-82-7

Formula C14H30 N4O 6 Mol. weight 350,42 g/mol

PEG2350 H2 N-PEG(7)-N3

alpha-Amino-omega-azido hepta(ethylene glycol)

CAS-No. 1333154-77-0

Formula C16 H34N4O 7 Mol. weight 394,46 g/mol

PEG3050 H2 N-PEG(8)-N3

alpha-Amino-omega-azido octa(ethylene glycol)

CAS-No. 857891-82-8

Formula C18 H38 N4O 8 Mol. weight 438,52 g/mol

PEG1081 H2 N-PEG(11)-N3

alpha-Amino-omega-azido undecae(ethylene glycol)

CAS-No. 1800414-71-4

Formula C 24H 50 N4O 11 Mol. weight 570,69 g/mol

PEG6895 Aminooxy-PEG(11)-N3*HCl

O-(35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)hydroxylamine hydrochloride H2NO

CAS-No. 2560602-21-1 net

Formula C 24H 50 N4O 12*HCl Mol. weight 586,68*36,45 g/mol

PEG3070 H2 N-PEG(23)-N3

alpha-Azido-omega-amino 23(ethylene glycol)

CAS-No. 2172677-19-7

Formula C 48 H98 N4O 23

Mol. weight 1099,3 g/mol

PEG3080 H2 N-PEG(35)-N3

alpha-Azido-omega-amino 35(ethylene glycol)

CAS-No. 749244-38-0

Formula C 72H146 N4O 35

Mol. weight 1627,94 g/mol

PEG3010 H2 N-PEG-N3 (3 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

Mol. weight 3000 Da

PEGylation

PEG3030 H2 N-PEG-N3 (5 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

Mol. weight 5000 Da

PEG3000 H2 N-PEG-N3 (10 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

Mol. weight 10000 Da

PEG3020 H2 N-PEG-N3 (20 kDa)

alpha-Amino-omega-azido poly(ethylene glycol)

Mol. weight 20000 Da

PEG2780 N3 -O2Oc-OH*CHA

[2-(2-azidoethoxy)ethoxy]acetic acid cyclohexylamine salt

CAS-No. 2098500-94-6

Formula C 6 H11N3 O4*C 6 H13 N Mol. weight 189,17*99,17 g/mol

PEG7950 N3 -AEEA-OK

Potassium 8-azido-3,6-dioxaoctanoate

CAS-No. 882518-90-3

Formula C 6 H10 KN3 O4 Mol. weight 39,10*188,16 g/mol

PEG5390 N3 -O2Oc-Ot Bu

8-Azido-3,6-dioxaoctanoic acid t-butyl ester

CAS-No. 251564-45-1

Formula C10 H19 N3 O4 Mol. weight 245,28 g/mol

PEG5000 N3 -TFBA-O2Oc

{2-[2-(4-Azido-2,3,5,6-tetrafluorobenzoyl-amino)ethoxy] ethoxy}acetic acid

CAS-No. 1993119-45-1

Formula C13 H12F4N4O 5 Mol. weight 380,25 g/mol

PEG5400 N3 -AEEEA*CHA

11-Azido-3,6,9-trioxaundecanoic acid cyclohexylamine

CAS-No. 172531-37-2

Formula C 8 H15N3 O 5*C 6 H13 N Mol. weight 233,22*99,17 g/mol

RL-4320 N3 -PEG(3)-NH-Suc

1-azido-13-oxo-3,6,9-trioxa-12-azahexadecan-16-oic acid

CAS-No. 1202400-17-6

Formula C12H22N4O 6 Mol. weight 318,33 g/mol

PEG5170 N3 -TOTA-Suc

1-Azido-4,7,10-trioxa-13-tridecaneamine succinamic acid

CAS-No. 1993176-74-1

Formula C14H26 N4O 6 Mol. weight 346,38 g/mol

RL-4370 N3 -PEG(3)-NH-DIG-OH

Diglycolic acid PEG3 azide

CAS-No. 239081-53-9

Formula C12H22N4O 7 Mol. weight 334,33 g/mol

PEG2345 N3 -PEG(4)-COOH

15-Azido-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 1257063-35-6

Formula C11H21N3 O 6 Mol. weight 291,3 g/mol

PEGylation

PEG1400 N3 -PEG(4)-NHS

15-Azido-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 944251-24-5

Formula C15H24N4O 8 Mol. weight 388,37 g/mol

PEG6915 N3 -PEG(4)-TFP

2,3,5,6-tetrafluorophenyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate

CAS-No. 1807505-33-4

Formula C17H21F4N3 O 6 Mol. weight 439,36 g/mol

PEG2790 N3 -O2Oc-O2Oc-OH

8-(8-Azido-3,6-dioxaoctanoylamido)-3,6-dioxaoctanoic acid

CAS-No. 1254054-60-8

Formula C12H22N4O 7 Mol. weight 334,33 g/mol

PEG4170 N3 -PEG(8)-COOH

alpha-Azido-omega-(propionic acid) octa(ethylene glycol)

CAS-No. 1214319-92-2

Formula C19 H37N3 O 10 Mol. weight 467,51 g/mol

PEG1405 N3 -PEG(8)-NHS

1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester

CAS-No. 1204834-00-3

Formula C 23 H40 N4O 12 Mol. weight 564,58 g/mol

PEG2015 N3 -PEG(9)-COOH

O-(2-Azidoethyl)-O-[2-(diglycolyl-amino)ethyl]heptaethylene glycol

CAS-No. 846549-37-9

Formula C 22H42N4O 12 Mol. weight 554,59 g/mol

PEG4180 N3 -PEG(12)-COOH

alpha-Azido-omega-(propionic acid) dodeca(ethylene glycol)

CAS-No. 1167575-20-3

Formula C 27H 53 N3 O 14 Mol. weight 643,72 g/mol

PEG1395 N3 -PEG(12)-NHS

1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid succinimidyl ester

CAS-No. 1108750-59-9

Formula C 31H 56 N4O 16 Mol. weight 740,79 g/mol

PEG6925 N3 -PEG(12)-TFP

2,3,5,6-tetrafluorophenyl 1-azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate

CAS-No. 2735663-71-3

Formula C 33 H 53 F4N3 O 14 Mol. weight 791,79 g/mol

PEG4190 N3 -PEG(24)-COOH

alpha-Azido-omega-(propionic acid) 24(ethylene glycol)

CAS-No. 1167575-20-3

Formula C 51H101N3 O 26 Mol. weight 1172,35 g/mol

PEG7650 N3 -PEG(24)-TFP

alpha-Azido-omega-(2,3,5,6-tetrafluorophenyl propionate) 24(ethylene glycol)

Formula C 57H101F4N3 O 26 Mol. weight 1320,41 g/mol

PEG7660 N3 -PEG(36)-TFP

alpha-Azido-omega-(2,3,5,6-tetrafluorophenyl propionate) 36(ethylene glycol)

CAS-No. 3017961-70-2

Formula C 81H149 F4N3 O 38 Mol. weight 1849,04 g/mol

PEGylation

PEG6655 N3 -PEG-SQA (3 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG6660 N3 -PEG-SQA (5 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG6645 N3 -PEG-SQA (10 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6650 N3 -PEG-SQA (20 kDa)

alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

PEG4900 N3 -EEEt-OH

2-[2-(2-Azidoethoxy)ethoxy]ethanol

CAS-No. 86520-52-7

Formula C 6 H13 N3 O 3

Mol. weight 175,19 g/mol

PEG3760 N3 -PEG(3)-OH

alpha-Azido-omega-hydroxy tetra(ethylene glycol)

CAS-No. 86770-67-4

Formula C 8 H17N3 O4

Mol. weight 219,24 g/mol

PEG5300 N3 -PEG(4)-OH

2-(2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethoxy) ethanol

CAS-No. 86770-68-5

Formula C10 H21N3 O 5

Mol. weight 263,29 g/mol

PEG6720 N3 -PEG(5)-OH

17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-ol

CAS-No. 86770-69-6

Formula C12H25N3 O 6 Mol. weight 307,34 g/mol

PEG1088 N3 -PEG(8)-OH

alpha-Azido-omega-hydroxy octa(ethylene glycol)

CAS-No. 352439-36-2

Formula C16 H33 N3 O 8 Mol. weight 395,45 g/mol

PEG1390 N3 -PEG(12)-OH

35-Azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol

CAS-No. 73342-16-2

Formula C 24H49 N3 O 12 Mol. weight 571,66 g/mol

PEG3770 N3 -PEG(24)-OH

alpha-Azido-omega-hydroxy 24(ethylene glycol)

CAS-No. 73342-16-2

Formula C 48 H97N3 O 24 Mol. weight 1100,29 g/mol

PEG3780 N3 -PEG(36)-OH

alpha-Azido-omega-hydroxy 36(ethylene glycol)

CAS-No. 73342-16-2

Formula C 72H145N3 O 36 Mol. weight 1628,92 g/mol

PEGylation

PEG4940

Biotin-PEG(3)-N3

11-[D(+)-Biotinylamino]-1-azido-3,6,9-trioxaundecane

CAS-No. 875770-34-6

Formula C18 H32N 6 O 5 S Mol. weight 444,55 g/mol

PEG6795

Biotin-PEG3-Ph(4-N3)

Biotin-PEG3-phenyl azide

CAS-No. 2088238-77-9

Formula C 25H37N7 O 6 S Mol. weight 563,67 g/mol

LS-4680

Biotin-PEG(3)-PyAz

6-(azidomethyl)-N-(13-oxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)nicotinamide

Formula C 25H38 N 8 O 6 S Mol. weight 578,69 g/mol

PEG7990

Biotin-PEG(4)-N3

(3aS,4S,6aR)-4-(28-azido-5,21-dioxo-9,12,15,18-tetraoxa-6,22-diazaoctacosyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one

CAS-No. 1006592-62-6

Formula C 27H49 N7 O 7S Mol. weight 615,79 g/mol

PEG8000

Biotin-PEG(4)-Picolyl-N3

(3aS,4S,6aR)-4-(1-(6-(azidomethyl)pyridin-3-ylamino)1,17-dioxo-4,7,10,13-tetraoxa-16-azahenicosan-21-yl) tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one

CAS-No. 2222687-71-8

Formula C 27H42N 8 O 7S Mol. weight 622,74 g/mol

PEG8100

Biotin-PEG(4)-SS-Azide

N-(2-((3-((3-azidopropyl)amino)-3-oxopropyl)disulfaneyl)ethyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide

CAS-No. 1260247-52-6

Formula C 29 H 52N 8 O 8 S 3 Mol. weight 736,96 g/mol

PEG7960

Biotin-PEG(4)-Dde-N3

N-(19-azido-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12-tetraoxa-16-azanonadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1802907-93-2

Formula C 32H 53 N7 O 8 S Mol. weight 695,87 g/mol

PEG7970

Biotin-PEG(4)-Dde-Picolyl-N3

N-(6-(azidomethyl)pyridin-3-yl)-15-(4,4-dimethyl-2,6dioxocyclohexylidene)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxa-16-azanonadecan-19-amide

CAS-No. 2055048-42-3

Formula C 38 H 57N9 O 9 S Mol. weight 815,98 g/mol

PEG4330

Biotin-PEG(7)-N3

alpha-Biotin-omega-azido hepta(ethylene glycol)

CAS-No. 1334172-75-6

Formula C 26 H48 N 6 O 9 S Mol. weight 620,76 g/mol

PEG4340

Biotin-PEG(11)-N3

[2-(2-aminoethoxy)ethoxy]acetic acid tert-butyl ester*HCl

CAS-No. 956494-20-5

Formula C 34H 64N 6 O 13 S Mol. weight 796,97 g/mol

PEG4350

Biotin-PEG(23)-N3

alpha-Biotin-omega-azido 23(ethylene glycol)

CAS-No. 956494-20-5

Formula C 58 H112N 6 O 25 S Mol. weight 1325,6 g/mol

PEGylation

PEG7190

Bromoacetamido-PEG(3)-N3

Bromoacetamido-tri(ethylene glycol)-azide

CAS-No. 940005-81-2

Formula C10 H19 BrN4O4 Mol. weight 339,19 g/mol

PEG7200

Bromoacetamido-PEG(11)-N3

Bromoacetamido-undeca(ethylene glycol)-azide

CAS-No. 2172677-17-5

Formula C 26 H 51BrN4O 12 Mol. weight 691,61 g/mol

PEG7210

Bromoacetamido-PEG(23)-N3

Bromoacetamido-23(ethylene glycol)-azide

CAS-No. 2735663-83-7

Formula C 50 H99 BrN4O 24 Mol. weight 1220,24 g/mol

RL-3700 Halo-PEG(2)-Azide

1-Azido-12-chloro-3,6-dioxadodecane

CAS-No. 2568146-55-2

Formula C10 H20 ClN3 O 2 Mol. weight 249,74 g/mol

PEG3150 I-PEG-N3 (3 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

Mol. weight 3000 Da

PEG3160 I-PEG-N3 (5 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

Mol. weight 5000 Da

PEG3130 I-PEG-N3 (10 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

Mol. weight 10000 Da

PEG3140 I-PEG-N3 (20 kDa)

alpha-Iodo-omega-azido poly(ethylene glycol)

Mol. weight 20000 Da

PEG1690 MeO-PEG(4)-N3

13-Azido-2,5,8,11-tetraoxa-tridecane

CAS-No. 606130-90-9

Formula C9 H19 N3 O4 Mol. weight 233,26 g/mol

PEG1705 MeO-PEG(8)-N3

25-Azido-2,5,8,11,14,17,20,23-octaoxapentacosane

CAS-No. 869718-80-9

Formula C17H35N3 O 8 Mol. weight 409,48 g/mol

PEG1660 MeO-PEG(12)-N3

37-Azido-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontane

CAS-No. 2170098-29-8

Formula C 25H 51N3 O 12 Mol. weight 585,69 g/mol

PEG1710 MeO-PEG(24)-N3

alpha-Methoxy-omega-azido-24(ethylene glycol)

CAS-No. 89485-61-0

Formula C 49 H99 N3 O 24

Mol. weight 1114,34 g/mol

PEGylation

PEG5350 HO-PEG-N3 (3 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

CAS-No. 73342-16-2

Mol. weight 3000 Da

PEG5360 HO-PEG-N3 (5 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

CAS-No. 73342-16-2

Mol. weight 5000 Da

PEG5330 HO-PEG-N3 (10 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

CAS-No. 73342-16-2 Mol. weight 10000 Da

PEG5340 HO-PEG-N3 (20 kDa)

alpha-Hydroxy-omega-azido poly(ethylene glycol)

CAS-No. 73342-16-2

Mol. weight 20000 Da

PEG3430 MeO-PEG(36)-N3

alpha-Methoxy-omega-azido-36(ethylene glycol)

CAS-No. 89485-61-0

Formula C 73 H147N3 O 36

Mol. weight 1642,95 g/mol

PEG1219 MeO-PEG-N3 (750 Da)

alpha-Methoxy-omega-azido poly(ethylene glycol)

Mol. weight 750 Da

PEG1225 MeO-PEG-N3 (2 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

Mol. weight 2000 Da

PEG2040 MeO-PEG-N3 (5 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

Mol. weight 5000 Da

PEG2045 MeO-PEG-N3 (10 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

Mol. weight 10000 Da

PEG2050 MeO-PEG-N3 (20 kDa)

alpha-Methoxy-omega-azido poly(ethylene glycol)

Mol. weight 20000 Da

PEG4830

Azido-PEG-Si(OMe)3 (3 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 3000 Da

PEG4835 Azido-PEG-Si(OMe)3 (5 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 5000 Da

PEGylation

PEG4840 Azido-PEG-Si(OMe)3 (10 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 10000 Da

PEG4845 Azido-PEG-Si(OMe)3 (20 kDa)

alpha-Azido-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 20000 Da

RL-3960 Azide-PEG(4)-SNAP

N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-1-azido-3,5,7,9-tetraoxadodecan-12-amide

Formula C 24H33 N9 O 6 Mol. weight 543,59 g/mol

RL-4030 PFB-mercaptopropionyl-PEG3-N3

Perfluorobiphenyl-mercaptopropionyl-PEG(3)-N3

Formula C 23 H21F9 N4O4 S

Mol. weight 620,49 g/mol

RL-3935 Mal-PEG(3)-N3

N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3-(2,5dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide

CAS-No. 1858264-36-4

Formula C15H23 N 5 O 6 Mol. weight 369,38 g/mol

PEG7215 N3 -PEG2-NMe3 mesylate

2-(2-(2-azidoethoxy)ethoxy)-N,N,N-trimethylethan-1-aminium

CAS-No. 1447915-25-4 net

Formula C10 H24N4O 5 S Mol. weight 312,39 g/mol

PEG2065 Biotin-TEG-ATFBA

Biotin-triethylenglycol-( p-azido-tetrafluorobenzamide)

CAS-No. 1264662-85-2

Formula C 27H37F4N7 O 6 S Mol. weight 663,68 g/mol

5.4. PEG-TCO

TCO1070 TCO-PEG(3)-NH2*HCl

trans-Cyclooctene-PEG(3)-amine

CAS-No. 2028288-77-7

Formula C19 H36 N2O 5*HCl Mol. weight 372,51*36,46 g/mol

TCO1040 TCO-PEG(4)-COOH

trans-Cyclooctene-PEG(4)-Acid

CAS-No. 1802913-21-8

Formula C 20 H35NO 8 Mol. weight 417,49 g/mol

TCO1010 TCO-PEG(4)-NHS

trans-Cyclooctene-PEG(4)-carboxy succinimidyl ester

CAS-No. 1621096-79-4

Formula C 24H38 N2O 10 Mol. weight 514,57 g/mol

TCO1020 TCO-PEG(12)-NHS

trans-Cyclooctene-PEG(12)-carboxy succinimidyl ester

CAS-No. 2185016-39-9

Formula C 40 H70 N2O 18 Mol. weight 866,99 g/mol

PEGylation

TCO1050 TCO-PEG(3)-mal trans-Cyclooctene-PEG(3)-maleimide

CAS-No. 1809356-72-6

Formula C 26 H41N3 O 8 Mol. weight 523,62 g/mol

5.5. PEG-Tetrazines

RL-2310 MeTz-PEG(4)-COOH

Methyltetrazine-PEG(4)-acid

CAS-No. 1802907-91-0

Formula C 20 H28 N4O 7 Mol. weight 436,56 g/mol

RL-2330 MeTz-PEG(4)-NHS

Methyltetrazine-PEG(4)-propanoyl succinimidyl ester

CAS-No. 1802907-92-1

Formula C 24H31N 5 O 9 Mol. weight 533,53 g/mol

RL-3905 MeTz-PEG(4)-STP

sodium 2,3,5,6-tetrafluoro-4-((1-(4-(6-methyl-1,2,4,5tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oyl)oxy)benzenesulfonate

Formula C 26 H27F4N4NaO 10 S Mol. weight 686,56 g/mol

RL-2370 MeTz-PEG(4)-NH2*HCl

Methyltetrazine-PEG(4)-amine HCL salt

CAS-No. 1802908-05-9 net

Formula C17H25N 5 O4*HCl Mol. weight 363,41*HCl g/mol

RL-2340 MeTz-PEG(4)-mal

Methyltetrazine-PEG(4)-maleimide

CAS-No. 1802908-02-6

Formula C 24H30 N 6 O 7

Mol. weight 514,53 g/mol

5.6. Tri-Functional PEG Cross-Linkers with Click Reactivity

PEG2910

NHS-PEG(NH-Boc)-alkyne (3 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 3000 Da

PEG2930

NHS-PEG(NH-Boc)-alkyne (5 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 5000 Da

PEG2900

NHS-PEG(NH-Boc)-alkyne (10 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 10000 Da

PEG2920

NHS-PEG(NH-Boc)-alkyne (20 kDa)

alpha-Succinimidyl ester-omega-(N-t-Butyloxycarbonyl-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 20000 Da

PEGylation

PEG2915

NHS-PEG(NH-Fmoc)-alkyne (3 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 3000 Da

PEG2935

NHS-PEG(NH-Fmoc)-alkyne (5 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 5000 Da

PEG2905

NHS-PEG(NH-Fmoc)-alkyne (10 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 10000 Da

PEG2925

NHS-PEG(NH-Fmoc)-alkyne (20 kDa)

alpha-Succinimidyl ester-omega-(N-(9-Fluorenylmethyloxycarbonyl)-L-propargyl-glycinyl) poly(ethylene glycol)

Mol. weight 20000 Da

6. Biotin-PEG Reagents

Interested in biotin reagents with click functionality? See chapter 5 PEGs Functionalized for Click-Chemistry

6.1. Biotin-PEG-Acids & -Esters

PEG2560 Biotin-O2Oc-OH

8-Biotinylamido-3,6-dioxaoctanoic acid

CAS-No. 1238575-77-3

Formula C16 H27N3 O 6 S Mol. weight 389,47 g/mol

Product details

PEG5280 Biotin-TOTA-glutaramic acid*DIPEA

5,21-dioxo-25-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)-10,13,16-trioxa-6,20-diazapentacosan-1-oic acid diisopropylethylamine salt

CAS-No. 1205744-09-7

Formula C 25H44N4O 8 S*C 8 H19 N Mol. weight 560,70*129,30 g/mol

PEG2565

Biotin-O2Oc-O2Oc-OH

8-Biotinylamido-3,6-dioxaoctanoic acid dimer

CAS-No. 1301706-65-9

Formula C 22H38 N4O 9 S Mol. weight 534,62 g/mol

PEG1515

Biotin-PEG(4)-COOH

15-Biotinamino-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 721431-18-1

Formula C 21H37N3 O 8 S Mol. weight 491,6 g/mol

PEG1870

Biotin-PEG(4)-NHS

15-Biotinamino-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 459426-22-3

Formula C 25H40 N4O 10 S Mol. weight 588,67 g/mol

PEGylation

PEG8090

Biotin-PEG(4)-SS-COOH

9,25-dioxo-29-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosan-1-oic acid

CAS-No. 1380166-80-2

Formula C 26 H46 N4O 9 S 3 Mol. weight 654,86 g/mol

PEG4440

Fmoc-L-Lys(PEG(4)-Biotin)-OH

N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[15-(biotinamido)-4,7,10,13-tetraoxa-pentadecanoyl]-L-lysine

CAS-No. 1334172-64-3

Formula C 42H 59 N 5 O 11 S Mol. weight 842,01 g/mol

PEG2071

Biotin-TEG-TFP

Biotin-tetra(ethylene glycol)-2,3,5,6-tetrafluorphenyl ester

CAS-No. 2985664-57-9

Formula C 27H37F4N3 O 8 S Mol. weight 639,66 g/mol

PEG1845

Biotin-PEG(4)-NHS-(Biotinidase resistant)

18-Biotinamino-17-oxo-4,7,10,13-tetraoxa-16-azaicosan1-oic acid succinimidyl ester

CAS-No. 1334172-61-0

Formula C 29 H47N 5 O 11 S Mol. weight 673,78 g/mol

PEG7760

Biotin-PEG(4)-TFP-(Biotinidase resistant)

18-Biotinamino-17-oxo-4,7,10,13-tetraoxa-16-azaicosan1-oic acid (2,3,5,6-tetrafluorophenyl) ester

Formula C 31H44F4N4O 9 S Mol. weight 724,76 g/mol

PEG1910

Biotin-PEG(4)-S-S-NHS

1-Biotinamino-15-oxo-3,6,9,12-tetraoxa-19,20-dithia-16-azatricosan-23-oic acid succinimidyl ester

CAS-No. 1260247-51-5

Formula C 30 H49 N 5 O 11 S 3 Mol. weight 751,93 g/mol

PEG6690

Biotin-PEG(6)-COOH

21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid

CAS-No. 1352814-10-8

Formula C 25H45N3 O 10 S Mol. weight 579,7 g/mol

PEG1051

Biotin-PEG(12)-COOH

alpha-Biotin-omega-(propionic acid)-dodecae(ethylene glycol)

CAS-No. 948595-11-7

Formula C 37H 69 N3 O 16 S Mol. weight 844,04 g/mol

PEG1860

Biotin-PEG(12)-NHS

alpha-Biotin-omega-carboxy succinimidyl ester dodeca(ethylene glycol)

CAS-No. 365441-71-0

Formula C 41H72N4O 18 S Mol. weight 941,09 g/mol

PEG5130 Biotin-PEG(12)-TFP

alpha-Biotin-omega-propionic acid (2,3,5,6-tetrafluorophenyl) ester dodeca(ethylene glycol)

CAS-No. 3017961-69-9

Formula C 43 H 69 F4N3 O 16 S Mol. weight 992,08 g/mol

PEG7770

Biotin-PEG(12)-TFP-(Biotinidase resistant)

alpha-Biotinyl-(2-aminobutyryl)-omega-(2,3,5,6-tetrafluorophenyl propionate) dodeca(ethylene glycol)

Formula C 47H76 F4N4O 17S Mol. weight 1077,18 g/mol

PEG4450 Fmoc-L-Lys(PEG(12)-Biotin)-OH

N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[alpha-Biotin-omega-propionyl dodeca(ethylene glycol)]-L-lysine

CAS-No. 1334172-65-4

Formula C 58 H91N 5 O 19 S Mol. weight 1194,43 g/mol

PEGylation

PEG4260

Biotin-PEG(24)-COOH

alpha-Biotin-omega-(propionic acid) 24(ethylene glycol)

CAS-No. 721431-18-1

Formula C 61H117N3 O 28 S Mol. weight 1372,65 g/mol

PEG4250

Biotin-PEG(24)-NHS

alpha-Biotin-omega-(succinimidyl propionate) 24(ethylene glycol)

CAS-No. 365441-71-0

Formula C 65H120 N4O 30 S Mol. weight 1469,72 g/mol

PEG7750

Biotin-PEG(24)-TFP

alpha-Biotin-omega-(2,3,5,6-tetrafluorophenyl propionate) 24(ethylene glycol)

Formula C 67H117F4N3 O 28 S Mol. weight 1520,71 g/mol

PEG4270

Biotin-PEG(48)-COOH

alpha-Biotin-omega-(propionic acid) 48(ethylene glycol)

CAS-No. 721431-18-1

Formula C112H218 N4O 53 S Mol. weight 2500,99 g/mol

PEG1053

Biotin-PEG-COOH (3 kDa)

alpha-Biotin-omega-carboxy poly(ethylene glycol)

Mol. weight 3000 Da

PEG1054

Biotin-PEG-COOH (5 kDa)

alpha-Biotin-omega-carboxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1052

Biotin-PEG-COOH (10 kDa)

alpha-Biotin-omega-carboxy poly(ethylene glycol)

Mol. weight 10000 Da

PEG1056

Biotin-PEG-NHS (3 kDa)

alpha-Biotin-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG1057

Biotin-PEG-NHS (5 kDa)

alpha-Biotin-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG1055

Biotin-PEG-NHS (10 kDa)

alpha-Biotin-omega-carboxy succinimidyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6590

Biotin-PEG-SQA (3 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG6595

Biotin-PEG-SQA (5 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEGylation

Product details

PEG6580

Biotin-PEG-SQA (10 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6585

Biotin-PEG-SQA (20 kDa)

alpha-Biotin-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

6.2. Biotin-PEG-Amines & -Hydrazines

PEG2760

Biotin-DOOA*HCl

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride

CAS-No. 862373-14-6

Formula C16 H30 N4O4 S*HCl Mol. weight 374,50*36,45 g/mol

Product details

RL-4060

Biotin-DOOA

Biotinyl-1-amino-3,6-dioxa-8-octanamine

CAS-No. 138529-46-1

Formula C16 H30 N4O4 S Mol. weight 374,50 g/mol

RL-4210

Biotin-PEG(3)-NH2

N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]biotinamide

CAS-No. 359860-27-8

Formula C18 H34N4O 5 S Mol. weight 418,22 g/mol

PEG8050 Biotin-TOTA

N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide

CAS-No. 183896-00-6

Formula C 20 H38 N4O 5 S Mol. weight 446,6 g/mol

PEG2110

Biotin-PEG(3)-NH2*TFA

N-Biotin-3,3‘-(2,2‘-oxybis(ethane-2,1-diyl)bis(oxy)) dipropan-1-amine trifluoroacetate

CAS-No. 1334172-59-6

Formula C 20 H38 N4O 5 S*CF 2CO 2H Mol. weight 446,60*114,01 g/mol

PEG5140 Biotin-TEG-O-NH2*HCl

N-(2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy) ethyl)-5-biotinamide hydrochloride

CAS-No. 1951424-88-6

Formula C18 H34N4O 6 S*HCl Mol. weight 434,55*36,45 g/mol

PEG1425

Biotin-PEG(4)-NHNH2

15-Biotinamino-4,7,10,13-tetraoxa-pentadecanoyl hydrazide

CAS-No. 756525-97-0

Formula C 21H39 N 5 O 7S Mol. weight 505,63 g/mol

PEG4290

Biotin-PEG(7)-NH2

alpha-Biotin-omega-amino hepta(ethylene glycol)

CAS-No. 1334172-76-7

Formula C 26 H 50 N4O 9 S Mol. weight 594,76 g/mol

PEG1044

Biotin-PEG(9)-NH2

alpha-Biotin-omega-amino-nona(ethylene glycol)

CAS-No. 960132-48-3

Formula C 30 H 58 N4O 11 S Mol. weight 682,88 g/mol

PEGylation

PEG4300

Biotin-PEG(11)-NH2

alpha-Biotin-omega-amino undeca(ethylene glycol)

CAS-No. 604786-74-5

Formula C 34H 66 N4O 13 S Mol. weight 770,97 g/mol

PEG4680

Biotin-PEG(11)-O-NH2*HCl

alpha-Biotinyl-omega-oxyamine-undeca(ethylene glycol) hydrochloride

Formula C 34H 66 N4O 14 S Mol. weight 786,97*36,45 g/mol

PEG4310

Biotin-PEG(23)-NH2

alpha-Biotin-omega-amino 23(ethylene glycol)

CAS-No. 604786-74-5

Formula C 58 H114N4O 25 S Mol. weight 1299,6 g/mol

PEG1046

Biotin-PEG-NH2 (3 kDa)

alpha-Biotin-omega-amino poly(ethylene glycol)

CAS-No. 604786-74-5

Mol. weight 3000 Da

PEG1047

Biotin-PEG-NH2 (5 kDa)

alpha-Biotin-omega-amino poly(ethylene glycol)

CAS-No. 604786-74-5

Mol. weight 5000 Da

PEG1045

Biotin-PEG-NH2 (10 kDa)

alpha-Biotin-omega-amino poly(ethylene glycol)

CAS-No. 604786-74-5

Mol. weight 10000 Da

6.3. Biotin-PEG-Alcohols & -Thiols

LS-3490

Biotin-AEEA-Tyramide

N-(2-(2-(2-(4-hydroxyphenethylamino)-2-oxoethoxy) ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 2561473-92-3

Formula C 24H36 N4O 6 S Mol. weight 508,63 g/mol

PEG8130

Biotin-PEG(4)-Dde-Tyramide

N-(15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-18-(4hydroxyphenyl)-3,6,9,12-tetraoxa-16-azaoctadecyl)5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d] imidazol-4-yl)pentanamide

CAS-No. 2814457-48-0

Formula C 34H 56 N4O 9 S Mol. weight 732,93 g/mol

LS-4260

Biotin-PEG(3)-SH

N-(17-mercapto-15-oxo-4,7,10-trioxa-14-azaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

CAS-No. 1208242-09-4

Formula C 23 H42N4O 6 S 2 Mol. weight 534,73 g/mol

LS-4240

Biotin-PEG(3)-SS-Py

N-(15-oxo-17-(pyridin-2-yldisulfaneyl)-4,7,10-trioxa-14azaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1Hthieno[3,4-d]imidazol-4-yl)pentanamide

Formula C 28 H45N 5 O 6 S 3

Mol. weight 643,88 g/mol

PEG4705 Biotin-PEG(11)-SH

alpha-Biotin-omega-mercapto undeca(ethylene glycol)

CAS-No. 1650579-23-9

Formula C 34H 65N3 O 13 S 2

Mol. weight 788,02 g/mol

PEGylation

PEG1213

Biotin-PEG-SH (3 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

CAS-No. 1030917-83-9

Mol. weight 3000 Da

PEG1214

Biotin-PEG-SH (5 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

CAS-No. 1030917-83-9

Mol. weight 5000 Da

PEG1212

Biotin-PEG-SH (10 kDa)

alpha-Biotin-omega-mercapto poly(ethylene glycol)

CAS-No. 1030917-83-9

Mol. weight 10000 Da

PEG4770

Biotin-PEG-OPSS (3 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

CAS-No. 1776111-43-3 Mol. weight 3000 Da

PEG4775

Biotin-PEG-OPSS (5 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

CAS-No. 1776111-43-3 Mol. weight 5000 Da

PEG4780

Biotin-PEG-OPSS (10 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

CAS-No. 1776111-43-3 Mol. weight 10000 Da

PEG4785

Biotin-PEG-OPSS (20 kDa)

alpha-Biotin-omega-pyridyl-2-disulfid poly(ethylene glycol)

CAS-No. 1776111-43-3 Mol. weight 20000 Da

6.4. Biotin-PEG-Maleimides

PEG1605

Biotin-PEG(3)-mal

N-(3-(2-(2-(3-(Biotinamino)propoxy)ethoxy)ethoxy) propyl)-3-maleimidylpropanamide

CAS-No. 525573-22-2

Formula C 27H43 N 5 O 8 S Mol. weight 597,72 g/mol

PEG1595

Biotin-PEG(11)-mal

alpha-Biotin-omega-maleimido undeca(ethylene glycol)

CAS-No. 1334172-60-9

Formula C 41H71N 5 O 16 S Mol. weight 922,09 g/mol

PEG4320

Biotin-PEG(23)-mal

alpha-Biotin-omega-maleimido 23(ethylene glycol)

CAS-No. 1334172-60-9

Formula C 65H119 N 5 O 28 S Mol. weight 1450,72 g/mol

PEG1049

Biotin-PEG-mal (3 kDa)

alpha-Biotin-omega-maleimido poly(ethylene glycol)

Mol. weight 3000 Da

PEGylation

Product details

PEG1050

Biotin-PEG-mal (5 kDa)

alpha-Biotin-omega-maleimido poly(ethylene glycol)

Mol. weight 5000 Da

PEG1048

Biotin-PEG-mal (10 kDa)

alpha-Biotin-omega-maleimido poly(ethylene glycol)

Mol. weight 10000 Da

6.5. Other Biotin-PEG Reagents

PEG2080 Biotin-TEG-Biotin

N,N‘-Bisbiotin-tetra(ethylene glycol)-diamine

CAS-No. 1263044-47-8

Formula C 30 H 52N 6 O 7S 2 Mol. weight 672,9 g/mol

PEG4850

Biotin-PEG-Si(OMe)3 (3 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 3000 Da

Product details

PEG4855

Biotin-PEG-Si(OMe)3 (5 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 5000 Da

PEG4860

Biotin-PEG-Si(OMe)3 (10 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 10000 Da

PEG4865

Biotin-PEG-Si(OMe)3 (20 kDa)

alpha-Biotinyl-omega-trimethoxysilyl poly(ethylene glycol)

Mol. weight 20000 Da

RL-4050

PFB-mercaptopropionyl-TOTA-Biotin

Perfluorobiphenyl-mercaptopropionyl-TOTA-Biotin

Formula

Mol. weight 848,84 g/mol

PEG6805

Biotin-PEG3-NH-Pentynoyl

alpha-Biotin-omega-pentynoyl 3(ethylene glycol)

CAS-No. 869082-82-6

Formula C 23 H38 N4O 6 S Mol. weight 498,64 g/mol

RL-4250 Biotin-PEG(4)-Gly-CBT

15-Biotinylamino-4,7,10,13-tetraoxa-pentadecanoyl-glycinyl-N-2-cyano-benzothiazole

CAS-No. 1907639-46-6

Formula C 31H43 N7 O 8 S 2 Mol. weight 705,85 g/mol

PEG1315 H2 N-PEG(12)-O-DMT

35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-(4,4‘-dimethoxytrityl)ether

CAS-No. 879571-23-0

Formula C 45H 69 NO 14 Mol. weight 848,03 g/mol

PEGylation

RL-8635

Biotin-PEG(4)-CINA

2-cyano-N-(16-oxo-20-((3aS,4S,6aR)-2-oxohexahydro1H-thieno[3,4-d]imidazol-4-yl)-3,6,9,12-tetraoxa-15azaicosyl)isonicotinamide

Formula C 27H40 N 6 O 7S

Mol. weight 592,71 g/mol

PEG7125

Biotin-PEG(4)-amido-PEG(24)-amido-PEG(24)-DSPE

(2R)-3-((hydroxy((4,80,156,172-tetraoxo-176-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)- 7,10,13,16,19,22, 25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,83,8 6,89,92,95,98,101,104,107,110,11

Formula C164H319 N 6 O 65PS

Mol. weight 3478,37 g/mol . circle-arrow-right

Find many more Biotinylation Regents in our brochure!

7. PEG-Thiols & Thiol-Reactive PEG Reagents

7.1. (Protected) Mercapto-PEG-Acids & -Esters

PEG1970 HS-PEG(4)-COOH

15-Mercapto-4,7,10,13-tertaoxa-pentadecanoic acid

CAS-No. 749247-06-1

Formula C11H22O 6 S Mol. weight 282,35 g/mol

PEG6710 Trt-S-PEG(4)-COOH*H2O

15-Tritylmercapto-4,7,10,13-tetraoxapentadecanoic acid monohydrate

CAS-No. 882847-05-4 net

Formula C 30 H36 O 6 S*H2O Mol. weight 524,67*18,01 g/mol

PEG1945 Ac-S-PEG(4)-NHS

15-Acetylthio-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester

CAS-No. 937025-17-7

Formula C17H27NO 9 S Mol. weight 421,46 g/mol

PEG1740 Mmt-S-PEG(4)-COOH

15-(4-Methoxytrityl)thio-4,7,10,13-tertaoxa-pentadecanoic acid

CAS-No. 1263047-31-9

Formula C 31H38 O 7S Mol. weight 554,69 g/mol

PEG2230 OPSS-PEG(4)-NHS

N-[3-(o-Pyridyldisulfido)propanoyl]-15-amino-4,7,10,13-tetraoxa-pentadecanoyl succinimidyl ester

CAS-No. 1334177-95-5

Formula C 23 H33 N3 O 9 S 2 Mol. weight 559,65 g/mol

PEGylation

PEG1120 HS-PEG(8)-COOH

alpha-Thio-omega-(propionic acid) octa(ethylene glycol)

CAS-No. 866889-02-3

Formula C19 H38 O 10 S Mol. weight 458,57 g/mol

PEG1955 Ac-S-PEG(8)-NHS

1-Acetylthio-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester

CAS-No. 1070798-99-0

Formula C 25H43 NO 13 S Mol. weight 597,67 g/mol

PEG1735 Mmt-S-PEG(8)-COOH

alpha-(4-Methoxytrityl)thio-octa(ethylene glycol)-omega-propionic acid

CAS-No. 1334177-82-0

Formula C 39 H 54O 11 S Mol. weight 730,91 g/mol

PEG2240 OPSS-PEG(8)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester octa(ethylene glycol)

CAS-No. 1252257-56-9

Formula C 31H49 N3 O 13 S 2 Mol. weight 735,86 g/mol

PEG1119 HOOC-PEG(8)-SS-PEG(8)-COOH

Propionic acid octa(ethylene glycol)-disulfid

CAS-No. 873013-93-5

Formula C 38 H74O 20 S 2 Mol. weight 915,11 g/mol

PEG1188 NHS-PEG(8)-SS-PEG(8)-NHS

N-Hydroxy-succinimidy-propionate octa(ethylene glycol)-disulfid

CAS-No. 947601-98-1

Formula C 46 H 80 N2O 24 S 2 Mol. weight 1109,26 g/mol

PEG2000 HS-FA-PEG(12)-COOH

alpha-(11-Mercapto-undecanoylamido)-omega-carboxy dodeca(ethylene glycol)

CAS-No. 1233721-06-6

Formula C 38 H75NO 15 S Mol. weight 818,06 g/mol

PEG3440 HS-PEG(12)-COOH

alpha-Thio-omega-(propionic acid) dodeca(ethylene glycol)

CAS-No. 1032347-93-5

Formula C 27H 54O 14 S Mol. weight 634,77 g/mol

PEG3630 Ac-S-PEG(12)-NHS

alpha-Acethylthio-omega-(succinimidyl propionate) dodeca(ethylene glycol)

CAS-No. 1334169-95-7

Formula C 33 H 59 NO 17S Mol. weight 773,88 g/mol

PEG4600 Mmt-S-PEG(12)-COOH

alpha-(4-Methoxytrityl)thio-dodeca(ethylene glycol)-omega-propionic acid

CAS-No. 1334169-94-6

Formula C 47H70 O 15 S Mol. weight 907,11 g/mol

PEG2250 OPSS-PEG(12)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester dodeca(ethylene glycol)

CAS-No. 924280-65-9

Formula C 39 H 65N3 O 17S 2 Mol. weight 912,07 g/mol

PEG5060 Ac-S-PEG(24)-NHS

alpha-Acethylthio-omega-(succinimidyl propionate) 24(ethylene glycol)

Formula C 57H107NO 29 S Mol. weight 1302,51 g/mol

PEGylation

PEG2260 OPSS-PEG(24)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester 24(ethylene glycol)

CAS-No. 924280-65-9

Formula C 63 H113 N3 O 29 S 2 Mol. weight 1440,7 g/mol

PEG7900 OPSS-PEG(30)-NHS

alpha-(o-Pyridyldisulfido)-omega-succinimidyl propionate 30(ethylene glycol)

Formula C 72H132N2O 34 S 2 Mol. weight 1633,94 g/mol

PEG3920 OPSS-PEG(36)-NHS

alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-(succinimidyl propionate) 36(ethylene glycol)

CAS-No. 924280-65-9

Formula C 87H161N3 O41 S 2 Mol. weight 1969,33 g/mol

PEG1099

HS-PEG-COOH (3 kDa)

alpha-Thio-omega-carboxy poly(ethylene glycol)

CAS-No. 1220112-75-3 Mol. weight 3000 Da

PEG1100

HS-PEG-COOH (5 kDa)

alpha-Thio-omega-carboxy poly(ethylene glycol)

CAS-No. 1220112-75-3 Mol. weight 5000 Da

PEG1098

HS-PEG-COOH (10 kDa)

alpha-Thio-omega-carboxy poly(ethylene glycol)

CAS-No. 1220112-75-3 Mol. weight 10000 Da

PEG8235 OPSS-PEG-NHS (3 kDa)

alpha-Butyric Acid NHS Ester-omega-Pyridyldithiopropanamido PEG

CAS-No. 1209465-68-8

Mol. weight 3000 Da

PEG8240 OPSS-PEG-NHS (5 kDa)

alpha-Butyric Acid NHS Ester-omega-Pyridyldithiopropanamido PEG

CAS-No. 1209465-68-8

Mol. weight 5000 Da

PEG8245 OPSS-PEG-NHS (10 kDa)

alpha-Butyric Acid NHS Ester-omega-Pyridyldithiopropanamido PEG

CAS-No. 1209465-68-8

Mol. weight 10000 Da

PEG8250 OPSS-PEG-NHS (20 kDa)

alpha-Butyric Acid NHS Ester-omega-Pyridyldithiopropanamido PEG

CAS-No. 1209465-68-8 Mol. weight 20000 Da

PEG1200

Trt-S-PEG-NHS (3 kDa)

alpha-Tritylthio-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1268168-99-5

Mol. weight 3000 Da

PEG1201

Trt-S-PEG-NHS (5 kDa)

alpha-Tritylthio-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1268168-99-5

Mol. weight 5000 Da

PEGylation

PEG1199

Trt-S-PEG-NHS (10 kDa)

alpha-Tritylthio-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1268168-99-5 Mol. weight 10000 Da

PEG6675

Trt-S-PEG-SQA (3 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 3000 Da

PEG6680 Trt-S-PEG-SQA (5 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 5000 Da

PEG6665 Trt-S-PEG-SQA (10 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 10000 Da

PEG6670 Trt-S-PEG-SQA (20 kDa)

alpha-3-(Tritylmercapto)propionyl-omega-squaric acid ethyl ester poly(ethylene glycol)

Mol. weight 20000 Da

7.2. (Protected) Mercapto-PEG-Amines & -Hydrazines

PEG1197 H2 N-PEG-SH*HCl (3 kDa)

alpha-Amino-omega-mercapto poly(ethylene glycol) hydrochloride

CAS-No. 1094307-00-2

Mol. weight 3000 Da

PEG1198 H2 N-PEG-SH*HCl (5 kDa)

alpha-Amino-omega-mercapto poly(ethylene glycol) hydrochloride

CAS-No. 1094307-00-2

Mol. weight 5000 Da

PEG1196 H2 N-PEG-SH*HCl (10 kDa)

alpha-Amino-omega-mercapto poly(ethylene glycol) hydrochloride

CAS-No. 1094307-00-2

Mol. weight 10000 Da

PEG1027 H2 N-PEG-STrt (3 kDa)

alpha-Amino-omega-tritylthio poly(ethylene glycol)

Mol. weight 3000 Da

PEG1028 H2 N-PEG-STrt (5 kDa)

alpha-Amino-omega-tritylthio poly(ethylene glycol)

Mol. weight 5000 Da

PEGylation

PEG1026

H2 N-PEG-STrt (10 kDa)

alpha-Amino-omega-tritylthio poly(ethylene glycol)

Mol. weight 10000 Da

PEG1114

Boc-NH-PEG-SH (3 kDa)

alpha-t-Butyloxycarbonylamino-omega-mercapto poly(ethylene glycol)

CAS-No. 1340550-07-3 Mol. weight 3000 Da

PEG1115

Boc-NH-PEG-SH (5 kDa)

alpha-t-Butyloxycarbonylamino-omega-mercapto poly(ethylene glycol)

CAS-No. 1340550-07-3

Mol. weight 5000 Da

PEG1113

Boc-NH-PEG-SH (10 kDa)

alpha-t-Butyloxycarbonylamino-omega-mercapto poly(ethylene glycol)

CAS-No. 1340550-07-3 Mol. weight 10000 Da

PEG1102

HS-PEG-CONH-NH-Boc (3 kDa)

alpha-Thio-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 3000 Da

PEG1103

HS-PEG-CONH-NH-Boc (5 kDa)

alpha-Thio-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 5000 Da

Product details

PEG1101 HS-PEG-CONH-NH-Boc (10 kDa)

alpha-Thio-omega-t-butyloxycarbonyl-hydrazido poly(ethylene glycol)

Mol. weight 10000 Da

7.3. (Protected) Hydroxy- & Methoxy-PEG-Thiols

PEG7010 Trt-S-EEE

S-Trityl-2-(2-(2-mercaptoethoxy)ethoxy)ethanol

CAS-No. 728033-15-6

Formula C 25H28 O 3 S Mol. weight 408,55 g/mol

Product details

PEG6730 Trt-S-EEEE

S-Trityl-2-(2-(2-(2-mercaptoethoxy)ethoxy)ethoxy) ethanol

CAS-No. 125607-10-5

Formula C 27H32O4 S Mol. weight 452,61 g/mol

PEG2095 Ac-S-TEG-OH

S-Acetyl-mercapto-tetra(ethylene glycol)

CAS-No. 223611-42-5

Formula C10 H20 O 5 S Mol. weight 252,33 g/mol

PEG3470 MeO-PEG(4)-SH

alpha-Methoxy-omega-mercapto tetra(ethylene glycol)

CAS-No. 52190-55-3

Formula C9 H20 O4 S Mol. weight 224,32 g/mol

PEGylation

PEG2470 Ac-S-OEG-OH

S-Acetyl-mercapto-octa(ethylene glycol)

CAS-No. 223611-42-5

Formula C18 H36 O 9 S Mol. weight 428,54 g/mol

PEG1167 MeO-PEG(7)-SH

alpha-Methoxy-omega-mercapto hepta(ethylene glycol)

CAS-No. 651042-82-9

Formula C15H32O 7S Mol. weight 356,48 g/mol

PEG1195 MeO-PEG(7)-SS-PEG(7)-OMe

Methoxy-hepta(ethylen glycol)-disulfid

CAS-No. 1044281-79-9

Formula C 30 H 62O 14 S 2 Mol. weight 710,93 g/mol

PEG5310 HO-PEG(8)-SH

alpha-Hydroxy-omega-mercapto octa(ethylene glycol)

CAS-No. 791620-96-7

Formula C16 H34O 8 S Mol. weight 386,5 g/mol

PEG3480 MeO-PEG(8)-SH

alpha-Methoxy-omega-mercapto octa(ethylene glycol)

CAS-No. 651042-83-0

Formula C17H36 O 8 S Mol. weight 400,53 g/mol

PEG2010 HS-FA-PEG(8)-OH

alpha-(11-Mercapto-undecanoylamido)-omega-hydroxy octa(ethylene glycol)

CAS-No. 1353948-95-4

Formula C 27H 55NO 9 S Mol. weight 569,79 g/mol

PEG3790 Ac-S-PEG(12)-OH

CAS-No. 165729-83-9

alpha-Acethylthio-omega-hydroxy dodeca(ethylene glycol) S O OH O 11

Formula C 26 H 52O 13 S Mol. weight 604,75 g/mol

PEG3490 MeO-PEG(12)-SH

alpha-Methoxy-omega-mercapto dodeca(ethylene glycol) MeO O SH 11

CAS-No. 134874-49-0

Formula C 25H 52O 12 S Mol. weight 576,74 g/mol

PEG5460 HO-PEG-SH (5 kDa)

alpha-Hydroxy-omega-mercapto poly(ethylene glycol)

CAS-No. 51987-25-8

Formula HO-CH2 -CH2 -PEG-CH2 -CH2 -SH

Mol. weight 5000 Da

PEG5470 HO-PEG-SH (3 kDa)

alpha-Hydroxy-omega-mercapto poly(ethylene glycol)

CAS-No. 51987-25-8

Formula HO-CH2 -CH2 -PEG-CH2 -CH2 -SH Mol. weight 3000 Da

O SH n

PEG5450 HO-PEG-SH (10 kDa)

alpha-Hydroxy-omega-mercapto poly(ethylene glycol)

CAS-No. 51987-25-8

Formula HO-CH2 -CH2 -PEG-CH2 -CH2 -SH Mol. weight 10000 Da

PEG1025 HO-PEG-STrt (5 kDa)

alpha-Hydroxy-omega-tritylthio poly(ethylene glycol)

CAS-No. 1653992-41-6

Mol. weight 5000 Da

PEGylation

PEG1023

HO-PEG-STrt (10 kDa)

alpha-Hydroxy-omega-tritylthio poly(ethylene glycol)

CAS-No. 1653992-41-6

Mol. weight 10000 Da

PEG1172

MeO-PEG-SH (750 Da)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 750 Da

PEG1169

MeO-PEG-SH (2 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 2000 Da

PEG1171

MeO-PEG-SH (5 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 5000 Da

PEG1168

MeO-PEG-SH (10 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 10000 Da

PEG1170

MeO-PEG-SH (20 kDa)

alpha-Methoxy-omega-mercapto poly(ethylene glycol)

Mol. weight 20000 Da

PEG4745

MeO-PEG-OPSS (750 Da)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 750 Da

PEG4750

MeO-PEG-OPSS (2 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 2000 Da

PEG4755

MeO-PEG-OPSS (5 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 5000 Da

PEG4760

MeO-PEG-OPSS (10 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 10000 Da

PEG4765

MeO-PEG-OPSS (20 kDa)

alpha-Methoxy-omega-pyridyl-2-disulfid poly(ethylene glycol)

Mol. weight 20000 Da

PEGylation

7.4. Bismercapto-PEG Reagents

PEG1122

HS-PEG-SH (2 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol) HS

CAS-No. 68865-60-1

Mol. weight 2000 Da

PEG1124 HS-PEG-SH (3 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol) HS

CAS-No. 68865-60-1

Mol. weight 3000 Da

PEG1124 HS-PEG-SH (3 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol) HS

CAS-No. 68865-60-1

Mol. weight 3000 Da

PEG1121 HS-PEG-SH (10 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol)

CAS-No. 68865-60-1

Mol. weight 10000 Da

PEG1123 HS-PEG-SH (20 kDa)

alpha,omega-Bis-mercapto poly(ethylene glycol) HS

CAS-No. 68865-60-1

Mol. weight 20000 Da

PEG4715 OPSS-PEG-OPSS (2 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

CAS-No. 259674-06-1

Mol. weight 2000 Da

PEG4725 OPSS-PEG-OPSS (3 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

CAS-No. 259674-06-1 Mol. weight 3000 Da

PEG4730 OPSS-PEG-OPSS (6 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol) S

CAS-No. 259674-06-1 Mol. weight 6000 Da

PEG4735 OPSS-PEG-OPSS (10 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

CAS-No. 259674-06-1 Mol. weight 10000 Da

PEG4740 OPSS-PEG-OPSS (20 kDa)

alpha,omega-Bis(pyridyl-2-disulfid) poly(ethylene glycol)

CAS-No. 259674-06-1 Mol. weight 20000 Da

PEGylation

7.5. Lipoamide-PEG Reagents

PEG3500

Lipoamide-PEG(4)-COOH

alpha-Lipoamide-omega-(propionic acid) tetra(ethylene glycol)

CAS-No. 1334172-69-8

Formula C19 H35NO 7S 2 Mol. weight 453,61 g/mol

PEG7480

Lipoamide-PEG(4)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) tetra(ethylene glycol)

Formula C 25H35F4NO 7S 2 Mol. weight 601,67 g/mol

PEG3510

Lipoamide-PEG(8)-COOH

alpha-Lipomide-omega-(propionic acid) octa(ethylene glycol)

CAS-No. 1334172-70-1

Formula C 27H 51NO 11 S 2 Mol. weight 629,82 g/mol

PEG7490

Lipoamide-PEG(8)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) octa(ethylene glycol)

CAS-No. 2767071-62-3

Formula C 33 H 51F4NO 11 S 2 Mol. weight 777,88 g/mol

PEG7500

Lipoamide-PEG(12)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) dodeca(ethylene glycol)

CAS-No. 2374870-92-3

Formula C 41H 67F4NO 15 S 2 Mol. weight 954,09 g/mol

PEG3540

Lipoamide-PEG(24)-COOH

alpha-Lipoamide-omega-(propionic acid) 24(ethylene glycol)

CAS-No. 1334172-71-2

Formula C 59 H115NO 27S 2 Mol. weight 1334,66 g/mol

PEG7510

Lipoamide-PEG(24)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) 24(ethylene glycol)

Formula C 65H115F4NO 27S 2 Mol. weight 1482,72 g/mol

PEG7520

Lipoamide-PEG(36)-TFP

alpha-Lipoamide-omega-(propionic acid 2,3,5,6-tetrafluorophenyl ester) 36(ethylene glycol)

Formula C 89 H163 F4NO 39 S 2 Mol. weight 2011,35 g/mol

PEG3570

Lipoamide-PEG(3)-biotin

alpha-Lipoamide-omega-biotinyl tri(ethylene glycol)

CAS-No. 1334172-74-5

Formula C 28 H 50 N4O 6 S 3 Mol. weight 634,91 g/mol

PEG3580

Lipoamide-PEG(11)-biotin

alpha-Lipoamide-omega-biotinyl undeca(ethylene glycol)

CAS-No. 960069-81-2

Formula C 42H78 N4O 14 S 3 Mol. weight 959,28 g/mol

PEG7530 Lipoamide-PEG(23)-biotin

alpha-Lipoamide-omega-biotinyl 23(ethylene glycol)

Formula C 66 H126 N4O 26 S 3 Mol. weight 1487,91 g/mol

PEGylation

PEG3550 Lipoamide-PEG(3)-mal

alpha-Lipoamide-omega-maleimido tri(ethylene glycol)

CAS-No. 1334172-72-3

Formula C 25H41N3 O 7S 2 Mol. weight 559,74 g/mol

PEG3560 Lipoamide-PEG(11)-mal

alpha-Lipoamide-omega-maleimido undeca(ethylene glycol)

CAS-No. 1334172-73-4

Formula C 39 H 69 N3 O 15 S 2 Mol. weight 884,11 g/mol

PEG3590

Lipoamide-PEG(4)-OMe

alpha-Lipoamide-omega-methoxy tetra(ethylene glycol)

CAS-No. 1334172-66-5

Formula C17H33 NO 5 S 2 Mol. weight 395,58 g/mol

PEG3600

Lipoamide-PEG(8)-OMe

alpha-Lipoamide-omega-methoxy octa(ethylene glycol)

CAS-No. 1334172-67-6

Formula C 25H49 NO 9 S 2 Mol. weight 571,79 g/mol

PEG3610

Lipoamide-PEG(12)-OMe

alpha-Lipoamide-omega-methoxy dodeca(ethylene glycol)

CAS-No. 1334172-68-7

Formula C 33 H 65NO 13 S 2 Mol. weight 748 g/mol

PEG3620 Lipoamide-PEG(24)-OMe

alpha-Lipoamide-omega-methoxy 20(ethylene glycol)

CAS-No. 1334172-68-7

Formula C 57H113 NO 25 S 2 Mol. weight 1276,63 g/mol

7.6. Maleimido-PEG-Acids & -Esters

PEG4870 Mal-O2Oc-OH

{2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy] ethoxy}acetic acid

CAS-No. 173323-23-4

Formula C10 H13 NO 6 Mol. weight 243,21 g/mol

PEG1555 mal-PEG(2)-COOH

3-(2-(2-(3-Maleimidopropanamido)ethoxy)ethoxy) propanoic acid

CAS-No. 756525-98-1

Formula C14H20 N2O 7 Mol. weight 328,32 g/mol

PEG1560 mal-PEG(2)-NHS

3-(2-(2-(3-Maleimidopropanamido)ethoxy)ethoxy) propanoic acid succinimidyl ester

CAS-No. 955094-26-5

Formula C18 H23 N3 O 9 Mol. weight 425,39 g/mol

PEG7540 mal-PEG(2)-TFP

3-(2-(2-(3-Maleinimidopropanamido)ethoxy)ethoxy) propanoic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 1431291-44-9

Formula C 20 H20 F4N2O 7

Mol. weight 476,38 g/mol

PEG1570 mal-PEG(4)-COOH

1-Maleimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid

CAS-No. 1263045-16-4

Formula C18 H28 N2O 9

Mol. weight 416,42 g/mol

PEGylation

PEG1575 mal-PEG(4)-NHS

15-[(3-Maleimid-1-yl)propanoylamido]-4,7,10,13-tetraoxa-pentadecanoyl succinimidyl ester

CAS-No. 756525-99-2

Formula C 22H31N3 O 11 Mol. weight 513,5 g/mol

PEG7550 mal-PEG(4)-TFP

1-Maleinimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 1807540-84-6

Formula C 24H28 F4N2O 9 Mol. weight 564,48 g/mol

PEG5110 Mal-L-Lys(Mal)-PEG(4)-COOH

15-(N-alpha,N-epsilon-Bis(3-(maleimido)propionyl)-L-lysinyl-amino)-4,7,10,13-tetraoxa-pentadecanoic acid

CAS-No. 1426164-52-4

Formula C 31H45N 5 O 13 Mol. weight 695,71 g/mol

PEG5120 Mal-L-Lys(Mal)-PEG(4)-TFP

2,3,5,6-Tetrafluorophenyl 15-(N-alpha,N-epsilon-bis(3-(maleimido)propionyl)-L-lysinyl-amino)-4,7,10,13-tetraoxa-pentadecanoate

CAS-No. 1426164-53-5

Formula C 37H45F4N 5 O 13 Mol. weight 843,77 g/mol

PEG3850 mal-PEG(6)-COOH

alpha-Maleimido-hexa(ethylene glycol)-omega-propionic acid

CAS-No. 1334177-79-5

Formula C 22H36 N2O 11 Mol. weight 504,53 g/mol

PEG1585 mal-PEG(6)-NHS

25-Maleimido-23-oxo-4,7,10,13,16,19-hexaoxa-22-azapentacosanoic acid succinimidyl ester

CAS-No. 1137109-21-7

Formula C 26 H39 N3 O 13 Mol. weight 601,6 g/mol

PEG6905 Mal-PEG(6)-TFP

2,3,5,6-tetrafluorophenyl 1-(2,5-dioxo-2,5-dihydro-1Hpyrrol-1-yl)-3-oxo-7,10,13,16,19,22-hexaoxa-4-azapentacosan-25-oate

Formula C 28 H36 F4N2O 11 Mol. weight 652,59 g/mol

PEG1615 mal-PEG(8)-COOH

1-Maleimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid

CAS-No. 1334177-86-4

Formula C 26 H44N2O 13 Mol. weight 592,63 g/mol

PEG1590 mal-PEG(8)-NHS

1-Maleimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid succinimidyl ester

CAS-No. 756525-93-6

Formula C 30 H47N3 O 15 Mol. weight 689,71 g/mol

PEG7560 mal-PEG(8)-TFP

1-Maleinimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 1924596-31-5

Formula C 32H44F4N2O 13 Mol. weight 740,69 g/mol

PEG2125 mal-PEG(12)-COOH

alpha-(3-(Maleinimido-1-yl)propanamido)-omega-(propionic acid)-dodecae(ethylene glycol)

CAS-No. 871133-36-7

Formula C 34H 60 N2O 17 Mol. weight 768,84 g/mol

PEG1550 mal-PEG(12)-NHS

1-Maleimido-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oic acid succinimidyl ester

CAS-No. 326003-46-7

Formula C 38 H 63 N3 O 19 Mol. weight 865,92 g/mol

PEGylation

PEG7570 mal-PEG(12)-TFP

alpha-Maleinimido-omega-(2,3,5,6-tetrafluorophenyl propionate) dodeca(ethylen glycol)

Formula C 40 H 60 F4N2O 17 Mol. weight 916,9 g/mol

PEG1600 mal-PEG(24)-COOH

alpha-Maleimido-24(ethylene glycol)-omega-propionic acid

CAS-No. 871133-36-7

Formula C 58 H108 N2O 29 Mol. weight 1297,47 g/mol

PEG1565 mal-PEG(24)-NHS

alpha-Maleimido-24(ethylene glycol)-omega-propionic acid succinimidyl ester

CAS-No. 326003-46-7

Formula C 62H111N3 O 31 Mol. weight 1394,55 g/mol

PEG7580 mal-PEG(24)-TFP

alpha-Maleinimido-24(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 2384191-62-0

Formula C 64H108 F4N2O 29 Mol. weight 1445,53 g/mol

PEG6935 Mal-PEG(36)-NHS

1-(3-maleimido-propionyl)-amido- 3,6,9,12,15,18,21,24,27, 30,33,36,39,42,45,48,51,54,57, 60,63,66,69,72,75,78,81,84, 87,90,93,96,99,102,105,108- hexatriacontaoxaundecahectan-111-oicacid N-hydroxysuccimid yl ester

CAS-No. 2136297-07-7

Formula C 86 H159 N3 O43 Mol. weight 1923,20 g/mol

PEG7590 mal-PEG(36)-TFP

alpha-Maleinimido-36(ethylen glycol)-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 3034327-58-4

Formula C 88 H156 F4N2O41 Mol. weight 1974,16 g/mol

PEG7600 mal-PEG(24)-PEG(24)-TFP

alpha-Maleinimido-bis[24(ethylen glycol)]-omega-propionic acid 2,3,5,6-tetrafluorophenyl ester

CAS-No. 3036983-56-6

Formula C115H209 F4N3 O 54

Mol. weight 2573,87 g/mol

PEG1059 mal-PEG-COOH (3 kDa)

alpha-Maleimido-omega-carboxy poly(ethylene glycol)

CAS-No. 948595-08-2

Mol. weight 3000 Da

PEG1060 mal-PEG-COOH (5 kDa)

alpha-Maleimido-omega-carboxy poly(ethylene glycol)

CAS-No. 948595-08-2

Mol. weight 5000 Da

PEG1058 mal-PEG-COOH (10 kDa)

alpha-Maleimido-omega-carboxy poly(ethylene glycol)

CAS-No. 948595-08-2 Mol. weight 10000 Da

PEG1062 mal-PEG-NHS (3 kDa)

alpha-Maleimido-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1073174-24-9

Mol. weight 3000 Da

PEG1063 mal-PEG-NHS (5 kDa)

alpha-Maleimido-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1073174-24-9

Mol. weight 5000 Da

PEGylation

PEG1061 mal-PEG-NHS (10 kDa)

alpha-Maleimido-omega-carboxy succinimidyl ester poly(ethylene glycol)

CAS-No. 1073174-24-9 Mol. weight 10000 Da

PEG6930 DOTA-PEG(11)-MAL*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-undeca(ethylene glycol)-omega-maleimido bistrifluoroacetate

CAS-No. 1325728-37-7

Formula C 47H 83 N7 O 21*2CF 3 CO 2H Mol. weight 1082,20*228,05 g/mol

PEG6910 DOTA(t Bu3)-PEG(11)-MAL

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate tri-t-butyl ester)-undeca(ethylene glycol)-omega-maleimido

Formula C 59 H107N7 O 21 Mol. weight 1250,52 g/mol

PEG6940 DOTA-PEG(23)-MAL*2TFA

alpha-(1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetate)-23(ethylene glycol)-omega-maleimido bistrifluoroacetate

Formula C 71H131N7 O 33*2CF 3 CO 2H Mol. weight 1610,83*228,05 g/mol

7.7. Methoxy-PEG-Maleimides

PEG2375 MeO-PEG(4)-mal

alpha-Methoxy-omega-maleimido tetra(ethylene glycol)

CAS-No. 1263044-81-0

Formula C16 H26 N2O 7 Mol. weight 358,39 g/mol

Product details

PEG2380

MeO-PEG(8)-mal

alpha-Methoxy-omega-maleimido octa(ethylene glycol)

CAS-No. 1334169-90-2

Formula C 24H42N2O 11 Mol. weight 534,6 g/mol

PEG1665

MeO-PEG(12)-mal

Maleimidyl-N-(2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-yl)propanamide

CAS-No. 88504-24-9

Formula C 32H 58 N2O 15 Mol. weight 710,81 g/mol

PEG1675

MeO-PEG(24)-mal

alpha-Methoxy-omega-maleimidyl-propanamide 24(ethylene glycol)

CAS-No. 88504-24-9

Formula C 56 H106 N2O 27 Mol. weight 1239,47 g/mol

PEG7350

Mal-PEG(4)-Lys(Fluorescein)-NH-PEG(24)-OMe

N-alpha-(maleinimido-tetra(ethylene glycol))-epsilon-(5(6)-carboxyfluorescein)-L-lysine alpha-(mPEG(24)) ester

Formula C94H149 N 5 O 39 Mol. weight 1973,2 g/mol

PEG3360 MeO-PEG(36)-mal

alpha-Methoxy-omega-maleimidyl-propanamide

36(ethylene glycol)

CAS-No. 88504-24-9

Formula C 80 H154N2O 39 Mol. weight 1768,07 g/mol

PEG3370 MeO-PEG(48)-mal

alpha-Methoxy-omega-maleimidyl-propanamide

48(ethylene glycol)

CAS-No. 88504-24-9

Formula C104H202N2O 51

Mol. weight 2296,7 g/mol

PEGylation

PEG2310 mal-PEG(4)-[PEG(4)-OMe] 3

Maleimido-PEG(4)-[PEG(4)-OMe] 3

CAS-No. 1333154-72-5

Formula C 58 H106 N 6 O 26

Mol. weight 1303,49 g/mol

PEG3420 mal-PEG(4)-[PEG(24)-OMe] 3

Maleimido-PEG(4)-[PEG(24)-OMe] 3 ester

CAS-No. 1334178-05-0

Formula C178 H346 N 6 O 86 Mol. weight 3946,64 g/mol

PEG7250 Mal-PEG(4)-Glu-PEG(24)-OMe

N-alpha-(maleinimido-tetra(ethylene glycol))-L-glutamic acid alpha-(mPEG(24)) ester

Formula C 72H134N4O 35 Mol. weight 1615,84 g/mol

PEG1150

MeO-PEG-mal (750 Da)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

CAS-No. 99126-64-4 Mol. weight 750 g/mol

PEG1147

MeO-PEG-mal (2 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

CAS-No. 99126-64-4 Mol. weight 2000 Da

PEG1149 MeO-PEG-mal (5 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

CAS-No. 99126-64-4 Mol. weight 5000 Da

PEG1146 MeO-PEG-mal (10 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

CAS-No. 99126-64-4 Mol. weight 10000 Da

PEG1148 MeO-PEG-mal (20 kDa)

alpha-Methoxy-omega-ethyl-maleimide poly(ethylene glycol)

CAS-No. 99126-64-4 Mol. weight 20000 Da

7.8. Bismaleimido-PEG Reagents

PEG1480 Mal-L-Lys(Mal)-hexylamine*TFA

N,N‘-(6-(6-aminohexylamino)-6-oxohexane-1,5-diyl) bis(3-maleinimido-propanamide)

CAS-No. 1301738-40-8

Formula C 26 H38 N 6 O 7 *CF 3 CO 2H Mol. weight 546,62*114,02 g/mol

PEG1485 mal-PEG(3)-mal

Bis-(1,13-(3-maleimidopropionyl)amido)-4,7,10-trioxatridecane

CAS-No. 756525-89-0

Formula C 24H34N4O 9 Mol. weight 522,55 g/mol

PEG2085 mal-PEG(11)-mal

alpha,omega-Bis-[(3-maleimid-1-yl)propanoylamido] undeca(ethylene glycol)

CAS-No. 854753-78-9

Formula C 38 H 62N4O 17 Mol. weight 846,92 g/mol

Product details

PEGylation

PEG1127 mal-PEG-mal (2 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

CAS-No. 146226-29-1 Mol. weight 2000 Da

PEG1129 mal-PEG-mal (3 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

CAS-No. 146226-29-1 Mol. weight 3000 Da

PEG1130 mal-PEG-mal (6 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

CAS-No. 146226-29-1 Mol. weight 6000 Da

PEG1126 mal-PEG-mal (10 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

CAS-No. 146226-29-1 Mol. weight 10000 Da

PEG1128 mal-PEG-mal (20 kDa)

alpha,omega-Bis-maleimido poly(ethylene glycol)

CAS-No. 146226-29-1 Mol. weight 20000 Da

PEG7670 Mal-PEG(12)-[PEG(11)-Mal] 3

Maleinimido-PEG(12)-[PEG(11)-amido-maleinimide] 3

Formula C140 H246 N12O 64

Mol. weight 3121,49 g/mol

PEG7155

Tetra[-amido-PEG(11)-mal]pentaerythritol

N,N‘-(42,42-bis(45-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,43-dioxo-2,9,12,15,18,21,24,27,30,33,36,39dodecaoxa-6,42-diazapentatetracontyl)-37,47-dioxo-3,6,9,12,15,18,21,24,27,30,33,40,44,51,54,57, 60,63,66,69,72,75,78,81-tetracosaoxa-36,48-diazatrioctaco

CAS-No. 2962831-27-0

Formula C141H248 N12O 64

Mol. weight 3135,56 g/mol

PEG7145 Tetra[-amido-PEG(23)-mal]pentaerythritol

N,N‘-(78,78-bis(81-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1yl)-5,79-dioxo-2,9,12,15,18,21,24,27,30,33,36,39,42,45,48, 51,54,57,60,63,66,69,72,75-tetracosaoxa-6,78-diazahenoctacontyl)-73,83-dioxo-3,6,9,12,

Formula C 237H440 N12O 112 Mol. weight 5250,10 g/mol . circle-arrow-right

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8. PEG Reagents with Hydroxy-, Methoxyand other Functionalities

PEG7065 Bis-Bromoacetamido-PEG(11)

N,N‘-(3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl)bis(2-bromoacetamide)

Formula C 28 H 54Br2N2O 13 Mol. weight 786,55 g/mol

PEG7680 Bromoacetamido-PEG(12)-[PEG(11)-bromoacetamide] 3

Bromoacetamido-PEG(12)-tris[PEG(11)-bromoacetamide]

Formula C120 H230 Br4N 8 O 56 Mol. weight 3000,75 g/mol

Product details

PEG1016 HO-PEG(8)-OH

Octa-ethylene glycol

CAS-No. 5117-19-1

Formula C16 H34O 9 Mol. weight 370,44 g/mol

PEG1015 HO-PEG(12)-OH

Dodeca-ethylene glycol

CAS-No. 25322-68-3

Formula C 24H 50 O 13 Mol. weight 546,65 g/mol

PEG1009 HO-PEG(28)-OH

alpha,omega-Bis-hydroxy 28(ethylene glycol)

CAS-No. 1053658-70-0

Formula C 56 H114O 29 Mol. weight 1251,49 g/mol

PEG1011 HO-PEG-OH (2 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 2000 Da

PEG1013 HO-PEG-OH (3 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 3000 Da

PEG1014 HO-PEG-OH (6 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 6000 Da

PEG1010 HO-PEG-OH (10 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 10000 Da

PEG1012 HO-PEG-OH (20 kDa)

alpha,omega-Bis-hydroxy poly(ethylene glycol)

CAS-No. 25322-68-3

Mol. weight 20000 Da

PEG1038 MeO-PEG(11)-OH

Undecae(ethylene glycol) methylether

CAS-No. 9004-74-4

Formula C 23 H48 O 12

Mol. weight 516,62 g/mol

PEGylation

PEG3270

MeO-PEG(23)-OH

alpha-Methoxy-omega-hydroxy-23(ethylene glycol)

CAS-No. 9004-74-4

Formula C 47H96 O 24

Mol. weight 1045,25 g/mol

PEG3280

MeO-PEG(36)-OH

alpha-Methoxy-omega-hydroxy-36(ethylene glycol)

CAS-No. 9004-74-4

Formula C 73 H148 O 37 Mol. weight 1617,93 g/mol

PEG1037

MeO-PEG-OH (750 Da)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 750 Da

O OH n

PEG1034

MeO-PEG-OH (2 kDa)

CAS-No. 9004-74-4

Mol. weight 2000 Da

alpha-Methoxy-omega-hydroxy poly(ethylene glycol) MeO O OH n

PEG1036

MeO-PEG-OH (5 kDa)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 5000 Da

PEG1033

MeO-PEG-OH (10 kDa)

alpha-Methoxy-omega-hydroxy poly(ethylene glycol)

CAS-No. 9004-74-4

Mol. weight 10000 Da

PEG1035

MeO-PEG-OH (20 kDa)

CAS-No. 9004-74-4

Mol. weight 20000 Da

alpha-Methoxy-omega-hydroxy poly(ethylene glycol) MeO O OH n

PEG5210

MeO-PEG(8)-DSPE

(2R)-3-((hydroxy(26-oxo-2,5,8,11,14,17,20,23-octaoxa27-azanonacosan-29-yl)oxy)phosphoryl)oxy)propane-1,2-diyl distearate

Formula C 59 H116 NO 17P

Mol. weight 1142,52 g/mol

PEG6855 MeO-PEG(13)-DSPE

(2R)-3-((hydroxy((41-oxo-2,5,8,11,14,17,20,23,26,29,32, 35,38-tridecaoxa-42-azatetratetracontan-44-yl)oxy) phosphoryl)oxy)propane-1,2-diyldistearate

Formula C 69 H136 NO 22P

Mol. weight 1362,81 g/mol

PEG0306 Palm3 -Cys-PEG-OH (3 kDa)

alpha-[(O,O‘-N-Trispalmitoyl)-2-amino-5,6-dihydroxy-4-thiahexanoylamido]-omega-hydroxy poly(ethylene glycol)

Mol. weight 3000 Da

PEG0506 Palm3 -Cys-PEG-OH (5 kDa)

alpha-[(O,O‘-N-Trispalmitoyl)-2-amino-5,6-dihydroxy-4-thiahexanoylamido]-omega-hydroxy poly(ethylene glycol)

Mol. weight 5000 Da

PEG1135 MeO-PEG-Br (750 Da)