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Alpha GPC
Alpha GPC powder in enhance brain function and an extra boost cycle Names Raw Alpha GPC powder, L-Alpha glycerylphosphorylcholine, choline alfoscerate Raw Alpha GPC powder An intermediate in phospholipid metabolism, Raw Alpha GPC powder works rapidly and reliably, primarily by delivering essential choline to the brain. Alpha GPC powder has significant nootropic properties, including memory enhancement and protection against brain aging. Extensive clinical trials involving thousands of participants have shown it to be an effective treatment for age-related memory loss associated with a variety of disorders, including Alzheimer’s disease, vascular dementia, and stroke. It also has neuroprotective anti-aging capabilities and studies suggest it may also be useful in the treatment of anxiety. It has non-nootropic benefits as well, including the ability to enhance cell membrane health and promote rapid recovery after physical exertion. Preliminary studies suggest that it may also act as a dopaminergic, promoting the release of the hormone dopamine, meaning it may serve as a potential treatment for neurodegenerative 1
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conditions such as Parkinson’s disease and may also be a mood enhancer. But for many nootropic users, the real strength of Alpha GPC powder is in its potentiating properties when taken in combination with other supplements. The additional choline that Raw Alpha GPC powder makes available to the brain can significantly amplify the cognitive enhancement effects of racetams. It can also prevent the minor but annoying headaches that are one of the few side effects associated with racetam nootropics. Alpha GPC powder is regulated in Europe, where it is prescribed for the treatment of Alzheimer’s disease and sold under the brand names Gliatilin and Delecit. In the US it is considered a dietary supplement and is available without a prescription. A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes. For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg. It is unsure how lower doses would benefit cognition, but the 1,200 mg appears to be consistently associated with benefit. Rat studies suggest that the effects of alpha-GPC oral ingestion peak at 300-600 mg/kg, which is an estimated human dose of 48-96 mg/kg (and for a 150lb human, 3,272-6,545 mg daily). Warning on Alpha GPC powder Despite being a natural source of the nutrient choline, supplementing in concentrated form can cause Alpha GPC powder side effects. One of the common Alpha GPC powder side effects is a headache or dizziness, which is often from producing too much choline in the brain. Some people, such as popular “biohacker” Dave Asprey, mention that they are high in choline and thus get headaches when dosing more. Other side effects of Raw Alpha GPC powder include things like confusion, erythema, and insomnia (from the stimulation). However, despite the possibilities of side effects, there is evidence that this 2
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nootropic is well tolerated at high doses. The LD50 (a measurement used to see what dosage kills 50% of a population) shows a dose of 10k mg / kg (equivalent of 6800 grams for 150 lb person) for rats. A more sensible study showed “no observed adverse effect level” with a dosage the equivalent of 1636 mg in a 150 lb person. Although traditionally known as being nonstimulatory, some persons do report cognitive stimulation with supplemental alpha-GPC. It may be prudent to take alpha-GPC alongside dietary fatty acids for absorption (due to it being a phospholipid), although this does not appear to be an absolute requirement. Further instructions L-alpha-glycerylphosphorylcholine (shortened to Alpha-GPC usually, also known as choline alphoscerate or glycerophosphocholine) is a choline containing phospholipid and an intermediate of lecithin metabolism or simply a lecithin molecule with two less fatty acids.It is a choline pro-drug, and is known to be a precursor to acetylcholine and phosphatidylcholine in the body following ingestion. Alpha-GPC is found as a naturally occurring constituent of red meat products and organ tissue but for the most part is scarce in appreciable amounts in naturally occurring sources.Most supplements containing Alpha-GPC are made synthetically, where it can be enzymatically created from egg or soy lecithin.Due to this synthesis and the source, it is sometimes referred to as a semisynthetic derivative of lecithin. Alpha GPC powder can quickly increase the synthesis of acetylcholine and neurotransmission in the brain, which is typically 20-30 minutes after oral consumption. Users can expect to experience an increase in mental alertness, concentration and mental focus within this timeframe. Consistent use in conjunction with a sensible diet and workout regime will experience the full performance and cognitive enhancing effects of Raw Alpha GPC powder within the first 2 weeks of use.
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