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GW 501516/Cardarine Basic information(1)
GW 501516/Cardarine Basic information............................................................................................... 1 1.GW 501516/Cardarine Basic information................................................................. 2 2.What is Cardarine Used for?.......................................................................................2 3.Cardarine: The Cure for Obesity?.............................................................................. 3
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1.GW 501516/Cardarine Basic information
Cardarine (GW-501516) is drug that binds to the PPAR receptor. It was first created by Glaxo Smith Kline and Ligand Pharmaceuticals in 1992. It was discovered that Cardarine, when binding to the PPAR receptor, recruits what is called the coactivator PGC-1αenzyme, which then increases the expression of genes involved in the expenditure of energy. Rats treated with Cardarine were shown to have increased fatty acid metabolism and increased protection against obesity from eating a bad diet, as well as an increased protection from type-2 diabetes. In another study on Rhesus monkeys, cardarine was shown to increase HDL (good cholesterol) and decrease LDL (bad cholesterol). Reasons for this effect appeared to be caused by an increased expression of the cholesterol transporter ABCA1. In other words, cardarine activates the same genetic pathways that are involved in exercise. In addition, cardarine was studied for use in treating cardio disease before its development was halted in 2007.
2.What is Cardarine Used for?
Cardarine is great for pretty much everything! Incredible endurance benefits from it are probably the most prominent reason to use this product. Not only has it proven to increase endurance in scientific studies, but when you use it for yourself you’d see that the results are nothing short of amazing! If you’re a cardio junkie or just like getting lean, it increase your run times. Your weight lifting sessions will be extended further, you’ll feel energized longer and ultimately get a lot more work done before you walk out of the gym every day.
Of course, fat loss is at the top of the list of reasons why many people love Cardarine so much. Striations and veins get more noticeable and your journey to fat loss becomes a lot easier, without the catabolic effects that most fat burners and drugs can have while trimming down. Fat loss from cardarine is a 2
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result of increased glucose uptake in skeletal muscle. Essentially, you’re making better use of the nutrients you consume every day and decreasing the amount of carbohydrates or fat stored as adipose tissue. As a result, cardarine is not only fat burning and anti-catabolic, but it’s also a little bit anabolic as well.
How to use cardarine powder? Cardarine can be stacked with pretty much anything, and it will enhance the results of the cycle. For anabolic-androgenic steroid users who like the drug trenbolone, cardarine is fantastic at combating the negative side effects of “tren” and even enhancing the positive effects.
3.Cardarine: The Cure for Obesity?
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THE PRIMARY ROLE is GW’s ability to rid the body of unwanted fatty tissue and it has become almost LEGENDARY. The chemical compounds in this particular PPAR agonist functions in differentiation of adipocytes.
Much like growth hormone, sarms powders like GW 501516 generates proinflammatory markers in adipose tissue and decreasing the activity of genes involved in lipogenesis. This means that the body is able to block fatty acid chains from forming and being stored as fat.
A study from Scientific Reports published in 2015 stated
‘GW501516 acts on PPAR beta cells that exclusively use body fat as energy in the same way the body would when going through ‘starvation mode’.
The study is quoted stating: ‘physiological and pathophysiological functions of PPAR and generated novel strategies to treat metabolic diseases’.
The activation of these particular genes in the body have been seen to burn body fat at such an alarming rate that it is being coined ‘the cure to obesity’.
There were absolutely no adverse side effects detected in the last 20 years of study and it was extremely rare to see muscle wasting at any point during the research.
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