How Sunitinib Malate works?

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How Sunitinib Malate works?

What Can We Used Sunitinib Malate For? Sunitinib Malate is used to treat adults with kidney cancer that has not spread (localized) and who are at high risk of RCC coming back again after having kidney surgery.

Sunitinib Malate is used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC).

Sunitinib Malate is used to treat a rare cancer of the stomach, bowel, or esophagus called gastrointestinal stromal tumor (GIST) and when you have taken the medicine imatinib mesylate and it did not stop the cancer from growing or you cannot take imatinib mesylate.

Gleevec is a registered trademark of Novartis Pharmaceuticals Corporation.

Sunitinib Malate is used to treat a type of pancreatic cancer known as pancreatic neuroendocrine tumors (pNET) that has progressed and cannot be treated with surgery.

How Sunitinib Malate Works?

Sunitinib Malate is a small-molecule inhibitor of multiple receptor tyrosine kinases, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. The agent inhibits platelet-derived growth factor receptors -(PDGFRα and 1

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PDGFRβ), vascular endothelial growth factor receptors (VEGFR1, VEGFR2, and VEGFR3), stem cell factor receptor (KIT), FMS-like tyrosine kinase 3, colony-stimulating factor receptor type 1, and the glial cell-line derived neurotrophic factor receptor (RET). Sunitinib Malate inhibition of the activity and function of these receptor tyrosine kinases has been demonstrated in biochemical and cellular assays and cell proliferation assays. The primary metabolite of Sunitinib Malate exhibits potency similar to the parent compound in biochemical and cellular assays.

Sunitinib Malate inhibits phosphorylation of multiple receptor tyrosine kinases (PDGFRβ, VEGFR2, KIT) in tumor xenografts expressing receptor tyrosine kinase targets in vivo and inhibits tumor growth and metastasis in some experimental models. The agent inhibits growth of tumor cells expressing dysregulated target receptor tyrosine kinases (PDGFR, RET, or KIT) in vitro and PDGFRβ-and VEGFR2-dependent tumor angiogenesis in vivo.

How To Take Sunitinib Malate?

The Sunitinib Malate dosage your doctor prescribes will depend on several factors. These include: 2

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❶ the type and severity of the condition you’re using Sunitinib Malate to treat ❷ other medical conditions you may have ❸ other medications you are taking Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

♦ Drug forms and strengths

Sunitinib Malate comes as a capsule that you swallow. It’s available in these strengths: 12.5 milligrams (mg), 25 mg, 37.5 mg, and 50 mg.

♦ Dosage for gastrointestinal cancer

The usual dosage of Sunitinib Malate for gastrointestinal stromal tumors (GISTs) is 50 mg once per day for 4 weeks. This is followed by 2 weeks without medication. Then, you’ll repeat the cycle.

You’ll likely continue taking Sunitinib Malate until your cancer worsens or your body can’t tolerate treatment with the drug. Your doctor will determine when you should stop taking Sunitinib Malate. For details on how Sunitinib Malate is used to treat GISTs, see the link as below.

♦ Dosage for kidney cancer

Sunitinib Malate is also used to treat a type of kidney cancer called advanced renal cell carcinoma (RCC). The usual dosage of Sunitinib Malate for advanced RCC is 50 mg once per day for 4 weeks. This is followed by 2 weeks without medication. Then, you’ll repeat the cycle.

You’ll likely continue taking Sunitinib Malate until your cancer worsens or your body can’t tolerate treatment with the drug. Your doctor will determine when you should stop taking Sunitinib Malate. For more 3

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information on how Sunitinib Malate is used to treat advanced RCC, see the link as below.

♦ Dosage for the adjuvant treatment of kidney cancer

Sunitinib Malate is also used as an adjuvant treatment for a type of kidney cancer called RCC after a nephrectomy (the surgical removal of a kidney). The usual dosage of Sunitinib Malate for this use is 50 mg once per day for 4 weeks. This is followed by 2 weeks without medication. You’ll typically repeat this cycle up to nine times. For details on how Sunitinib Malate is used as an adjuvant treatment for RCC, see the link as below.

♦ Dosage for pancreatic cancer

The usual dosage of Sunitinib Malate for advanced pancreatic neuroendocrine tumors (pNETs) is 37.5 mg once per day.

You’ll likely continue taking Sunitinib Malate until your cancer worsens or your body can’t tolerate treatment with the drug. Your doctor will determine when you should stop taking Sunitinib Malate.

Noted: the dosage was only reference, please help to check more details by this website:www.fda.gov .

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