NAD+ & NMN as Supplement

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NAD+ & NMN as Supplement

What Foods Contain NMN? NMN occurs naturally in food such as avocado, broccoli, cabbage, and tomatoes. Now, you might be thinking: “If NMN is found in food, can’t I increase my levels of NAD+ by eating more of those foods? “ That’s a good question and we do encourage you to eat a healthy diet. But, here’s the issue: Although NMN occurs in these foods, the concentrations are less than 1 mg per kg of food.

In other words, to get about 1mg of NMN, you’d have to eat about 1kg of broccoli!

It’s been found that to boost the levels of NAD+ in humans, the levels of NMN should be in the hundreds of milligrams per dose. This is way higher than what we can get from our diets, no matter how much broccoli we eat.

Why Supplement With NMN? As we have shown, NMN plays a crucial role in creating NAD+. When we have high levels of NAD+ in our bodies, cellular energy increases which becomes the fuel of life—powering every organ and cell in our bodies and protecting us from DNA damage. NAD+ also activates Sirtuins which are essential in increasing our life expectancy and slowing down the aging process.

Supplementing with NMN directly increases the levels of NAD+ in our bodies, which counteracts the natural decline that occurs as we age. Research has shown that by supplementing with NMN, the NAD+ levels in older people can be raised to that of a 20-year-old!

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AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

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(1) What is Nicotinamide Adenine Dinucleotide (NAD+) and its Works?

NAD+ is an essential coenzyme required for life and cellular functions. Enzymes are catalysts that make biochemical reactions possible. Coenzymes are “helper” molecules that enzymes need in order to function.

NAD+ is the most abundant molecule in the body besides water, and without it, an organism would die. NAD+ is used by many proteins throughout the body, such as the sirtuins, which repair damaged DNA. It is also important for mitochondria, which are the powerhouses of the cell and generate the chemical energy that our bodies use.

(2) Methods to Increase NAD+ levels Fasting or reducing calorie intake, better known as calorie restriction, has been shown to increase NAD+ levels and sirtuin activity. In mice, the increased NAD+ and sirtuin activity from calorie restriction has been shown to slow the aging process. Although NAD+ is present in some foods, the concentrations are too low to affect intracellular concentrations.

Taking certain supplements, such as NMN, has been shown to increase NAD+ levels.

(3) NAD+ Supplement as NMN Intracellular concentrations of NAD+ decrease from aging as normal cellular functions deplete NAD+ supplies over time. Healthy levels of NAD+ are thought to be restored by supplementation with NAD+ precursors. According to research, precursors such as NMN and nicotinamide riboside (NR) are viewed as supplements of NAD+ production, increasing concentrations of NAD+. David Sinclair, a NAD+ researcher from Harvard, says, “Feeding or administering NAD+ directly to organisms is not a practical option. The NAD+ molecule cannot readily cross cell membranes to enter cells, and therefore would be unavailable to positively affect metabolism. Instead, precursor molecules to NAD+ must be used to increase bioavailable levels of NAD+.” This means NAD+ cannot be used as a direct supplement, because it is not easily absorbed. NAD+ precursors are more easily absorbed than NAD+ and are more effective supplements.

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AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

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What is Nicotinamide Mononucleotide(NMN)?

Nicotinamide Mononucleotide (CAS:1094-61-7), also called NMN, which is a naturally occurring compound that is in small amounts in the human body as well as some foods.

NMN is orally bioavailable, and when taken orally can support NAD+ levels within liver and muscle tissue.

Recent research has suggested that NMN may support cardiovascular health, energy production, cognitive health, and well as retinal and bone health. One especially interesting finding of NMN research is that it may promote DNA repair and support the activation of the SIRTUIN genes which are thought to play a role in healthy aging.

※ How is NMN Synthesized In the Body?

NMN is produced from B vitamins in the body. The enzyme responsible for making NMN in the body is called nicotinamide phosphoribosyltransferase (NAMPT). NAMPT attaches nicotinamide (a vitamin B3) to a sugar phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate). NMN can also be made from ‘nicotinamide riboside’ (NR) through the addition of a phosphate group.

‘NAMPT’ is the rate-limiting enzyme in the production of NAD+. This means lower levels of NAMPT cause decreased NMN production, resulting in decreased NAD+ levels. Adding precursor molecules like NMN can also speed up NAD+ production.

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AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com