Nicotinamide riboside chloride

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Nicotinamide riboside chloride

Product Description

Basic Characteristics Product Nicotinamide riboside chloride Name CAS 23111-00-4 Number Molecul ar C11H15ClN2O5 Formula Formula 290.7 Weight 23111-00-4 Nicotinamide riboside chloride Nicotinamide riboside (chloride) Synony ms 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahy drofuran-2-yl)pyridin-1-ium chloride Nicotinamide ribose chloride Appeara White powder nce Storage and 0 – 4 C for short term (days to weeks), or -20 C for long term Handlin (months). g

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Nicotinamide riboside chloride Description Nicotinamide Riboside Chloride (NIAGEN) is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ .NIAGEN is generally recognized as safe (GRAS) in the United States for use in food products. Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride powder is used in dietary supplements.

Nicotinamide riboside chloride Mechanism of Action Nicotinamide Riboside Chloride (NIAGEN) is the chloride salt form of nicotinamide riboside(NR). NR is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NR blocks degeneration of surgically severed dorsal root ganglion neurons ex vivo and protects against noise-induced hearing loss in living mice. Nicotinamide riboside powder prevents muscle, neural and melanocyte stem cell senescence. Increased muscular regeneration in mice has been observed after treatment with nicotinamide riboside, leading to speculation that it might improve regeneration of organs such as the liver, kidney, and heart. Nicotinamide riboside also lowers blood glucose and fatty liver in prediabetic and type 2 diabetic models while preventing the development of diabetic peripheral neuropathy. Note: Nicotinamide Riboside chloride is a α/β mixture.

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Nicotinamide riboside chloride Application Nicotinamide riboside chloride powder is registered with CAS number 23111‐00‐4 and EC number 807‐820‐5. Its IUPAC name is 1‐[(2R,3R,4S,5R)‐3,4‐dihydroxy‐5‐(hydroxymethyl)oxolan‐2 ‐yl]pyridin‐1‐ium‐3‐carboxamide;chloride. The molecular formula of nicotinamide riboside chloride is C11H15N2O5Cl, and its molecular weight 290.7 g/mol. Nicotinamide Riboside Chloride (NIAGEN) is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . The body needs NAD+ to work normally. Low levels of NAD+ can cause medical problems. Taking nicotinamide riboside can help raise these low NAD+ levels.

Benefits of Nicotinamide riboside chloride Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride powder is a source of vitamin B3 (niacin) and use Nicotinamide riboside Chloride powder can enhance oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

Reference 3

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[1] Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.

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[8] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and 4

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Mitochondrial Gene Expression in Alzheimer’s Mouse Models.

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[9] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.

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