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Nootropic Coluracetam
Racetam Family of Nootropic– Coluracetam Coluracetam (BCI-540, or MKC-231) is a fat-soluble nootropic in the racetam-class of compounds. Coluracetam is much more potent than the original racetam, Piracetam. Coluracetam was patented by Mitsubishi Tanabe Pharma of Japan in 2005. Making it one of the newest racetam-based nootropics. The patent for Coluracetam was later sold to BrainCells, Inc. in San Diego, California. BrainCells is a small, privately-held biopharmaceutical company specializing in developing compounds for the treatment of major depressive disorder (MDD), treatment resistant depression (TRD), and Alzheimer’ s Disease. Coluracetam is similar in structure to Piracetam. And like all racetam nootropics, has a pyrrolidone nucleus at its core. The latest clinical research indicates potential for treating depressive disorders, and retinal and optic nerve damage. Coluracetam is a very strong choline targeting supplement. It boosts your brain’ s choline conversion to acetylcholine (ACh) through the high affinity choline uptake (HACU) process. Which increases alertness, attention to detail and memory. Some research, and personal experience shows Coluracetam may affect AMPA receptors. Making it a potential ampakine nootropic. Which could explain the stimulant-like effects without the side effects of traditional stimulants. Coluracetam also shows some anxiolytic (anti-anxiety) qualities helping improve mood and quieting anxiety.
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How Coluracetam Works(Mechanism of Action) Like most racetam compounds, coluracetam(CAS:135463-81-9) works mainly by increasing levels of the neurotransmitter acetylcholine, which is strongly associated with learning, memory, and cognition. However, the way that coluracetam modulates acetylcholine levels is unique. Typically, racetams trigger acetylcholine production by stimulating the appropriate receptors, but coluracetam does so by enhancing high-affinity choline uptake, or HACU. The HACU system determines the rate at which choline is drawn into neurons for conversion into acetylcholine. By increasing the rate at which choline is drawn into nerve cells, coluracetam promotes acetylcholine production and causes brain levels of this crucial neurotransmitter to rise. It has also been shown to create an increase in the high-affinity choline transporter molecule CHT1, which leads to the rapid availability of choline for uptake. Together these actions lead to higher levels of acetylcholine, which are associated with enhanced cognition and memory.
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