Urolithin A Powder

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Urolithin A Powder

Urolithin A Backgroud Pomegranate’s heart benefits have led researchers to investigate in what ways this red fruit can keep us healthy. In a recent finding, Swiss researchers have identified a new molecule that results from digesting two compounds found in pomegranates: punicalagins and ellagitannins. This unique molecule, known as urolithin A, helps rejuvenate mitochondria, our cellular powerhouses. Urolithin A opens the door to potential new therapeutic treatments against age-related disorders, including frailty, which is a risk factor for disability, hospitalizations, and mortality.

Urolithin A Overview Urolithin A is a metabolite compound, which belongs to the class of organic compounds known as benzo-coumarins. It is the end product produced from the consumption of food that contains ellagitannins (polyphenols) and is metabolized by the body’s gut bacteria. In other words, Urolithin A is produced when an individual ingests food sources containing ellagitannins.

Urolithin A does not occur naturally in its end form. Ellagitannin food sources, like certain types of berries and pomegranate, must be metabolized with gut bacteria to be created. In order for the 1

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compound to have viable applications, it has to be manufactured in a lab, or in other words, artificial Urolithin A must be produced so that it can be utilized.

Scientific studies have shown that Urolithin A possesses anti-ageing properties. It is said to aid in muscle mass formation, features anti-inflammatory properties, and has even shown potential in improving cognitive health in ageing individuals.

Urolithin A Mechanism of Action How does Urolithin A work? Ellagic acids and Ellagitannins are Urolithin A precursors.

Ellagitannins are hydrolyzed from the intestine into release Ellagic acid, and this is processed from the gut microflora to urolithins through the increasing loss in 1 of its two lactones successive removal of hydroxyl groups. Once It’s consumed in the intestines, then Urolithin A powder enters the flow System of this intestine.

Mitophagy, according to Wikipedia definition, is the selective degradation of your mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. However, as we age, Mitophagy function becomes less efficient. Luckily, Urolithin A is approved to stimulate mitophagy in a conserved manner across different species.

Benefits/Effects of Urolithin A ❶ Urolithin A Helps Fight Cancer Despite aggressive surgical care and chemotherapy, nearly 50% of people with colorectal cancers develop recurrent tumors. This may be due in part to the survival of dangerous colon-cancer stem cells that resist conventional chemotherapy and act as ‘’seeds’’ for subsequent cancers.6

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In an interesting finding, researchers exposed colon-cancer stem cells from a patient with colorectal cancer to either a mixture containing 85% urolithin A or 30% urolithin A. The results were impressive. The higher urolithin A concentration mixture was most effective at inhibiting the number and size of colon-cancer stem cells and inhibiting the activity of aldehyde dehydrogenase, a marker of chemoresistance.

This therapeutic approach is exciting because traditional therapies against cancer lack the ability to kill or stop the proliferation of cancerous stem cells. These new findings support the notion that a nutrient approach may prove valuable as an alternative treatment or preventive intervention for targeting these harmful cells. ❷ Urolithin A -- Neuroprotective Effects The connection between pomegranate and its neuroprotective effects against Alzheimer’s disease has been well established in animal studies.8 However, the bioactive constituents for this action were unknown until now.

Alzheimer’s disease is expected to affect over 115 million people worldwide by the year 2050.A group of researchers looked at a previous animal study that reported on the anti-Alzheimer’s effects of pomegranate extract constituents.

The team evaluated the ability of these components to cross the blood-brain barrier and found that a methylated form of urolithin A (mUA), derived from pomegranate, along with other urolithins were capable of doing so.

And, although more research is needed, the authors concluded that urolithins are the possible compounds responsible for the anti-Alzheimer’s effects that include protection against neurotoxicity and b-amyloid fibrillation. These results are promising, and suggest the need for exploring other naturally-based dietary intervention strategies for preventing or slowing down the progression of Alzheimer’s.

The results and data from these various studies further support the importance of polyphenol metabolite compounds like urolithin A from pomegranate and their role in the fight against colon cancer and 3

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neurodegenerative diseases.

Studies also have shown that Urolithin A can improve muscle strength and endurance in ageing individuals. Recent research shows that preliminary evidence presents promising other benefits of Urolithin A, which include the following: -Anti-inflammatory -Anticarcinogenic -Antioxidant -Antiglycative -Antimicrobial Urolithin A is also strongly seen as a supplement to protein products to enhance the effects of exercise, as well as to reduce obesity.

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