Urolithin A Powder(2)

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Urolithin A Powder(2)

Urolithin A Side Effects In the aforementioned human clinical trial, no adverse side effects were reported. In investigations over a series of preclinical and clinical studies, there seems to be evidence of support to the safety of Urolithin A use.

No toxicological effects have been reported, even in studies that involved the highest dose given to rats in such studies.

Urolithin A is set to transform the anti-aging industry. Clinical studies are still in their early stages but most trials reveal positive results with no adverse side effects. From food to supplements, Urolithin A is bound to be the next new superfood discovery that everyone should be taking.

Urolithin A Food Sources As mentioned, Urolithin A in its end form does not appear naturally. It is not known to be found in any food sources. However, the precursor to the compound can be found in certain fruits and nuts. Food sources that contain ellagitannins such as pomegranate, raspberries, strawberries, cloudberries, and walnuts are some examples.

The ellagitannins in these fruits and nuts are hydrolyzed in the gut to produce ellagic acid, which is then further processed in the gut and metabolized with gut microflora into Urolithin A. 1

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It is important to note that Urolithin A does not always occur when ingested. Some people’s guts do not have a healthy mix of microflora needed to convert ellagic acid into Urolithin A. This means that not everyone will produce Urolithin A in their gut if they eat pomegranate, walnuts, or berries. It all depends on the gut bacteria present in your body.

Urolithin A Manufacturing Process Urolithin A is manufactured via chemical syntheses using one of the two processes described below. Both processes involve an Ullmann coupling reaction, followed by a Lewis acid treatment to yield a highly purified urolithin A product.

The final product is purified by standard means of treatment in solvents, filtered, washed, and dried to obtain pure urolithin A. The product is later subjected to a particle size reduction.

According to well-established processes, Urolithin A powder is synthetically manufactured and purified in several main steps to a highly pure specification of 99%. Raw Materials and processing steps involved in the synthesis of urolithin A include 2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminum chloride, Toluene, DMSO, Methanol, Acetic Acid, and TBME (tert-butyl-methyl ether).

Synthetic Urolithin A VS Natural Urolithin A As mentioned above, Urolithin A is a gut‐derived bacterial metabolite of ellagitannins(ET) or ellagic acid (EA). If you want to obtain a large quantity of Urolithin A, you have to first eat bulky fruits, and then wait for them to transfer from ellagitannins and ellagic acid to Urolithin A. This process is long, and its purity is low, and most importantly, it will be extremely expensive to do so.

Not everyone has the right microflora that can make the metabolite. In addition, this process can never be applied to mass production in a GMP-compliant manufacturing facility.

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The good news is that, as a novel ingredient, Urolithin A is finally commercially available in 2019 from Cima Science. It now can be synthesized in the lab and factory. The synthetic urolithin A is identical in structure to natural urolithin A. The manufacturing capability is up to 3000 kgs or 2.5 tons/month.

Urolithin A Safety Urolithin A is approved by the European Union as a novel food ingredient.

The US Food and Drug Administration (FDA) in 2018 has granted urolithin A its GRAS status used in dietary supplement formula. GRAS means that Urolithin A is generally regarded as safe with a dosage of 500mg to 1 gram per serving.

Urolithin A safety was researched at a series of preclinical and clinical trials, which encourage its health safety for its intended uses.

Repeated dosage 28-day and 90-day studies of urolithin A in rats didn’t demonstrate any toxicological impact in some of the parameters measured in any way doses tested.

Supplementation for up to 90 days with urolithin A didn’t lead to any signs of neurological or reproductive toxicities in improved screening periods of repeated-dose studies such as evaluation of spermatogenesis or oestrus cycles, ophthalmoscopic examinations, operational observatory battery display, and motor activity assessments.

Welcome To Buy Urolithin A/Urolithin A 8-Methyl Ether Bulk Powder from AASraw!

The discovery of urolithin A, that results from the punicalagins and ellagitannins compounds found in pomegranates, provides new opportunities to fight age-related decline of mitochondrial function and the resulting frailty and loss of muscle.

By helping cells renew themselves and optimizing muscle performance, pomegranate extract and its newly identified metabolite, 3

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urolithin A—could prove successful.

Along with these findings, there is supportive evidence of the powerful effects that urolithin A has against Alzheimer’s disease and cancer, offering yet another tool to fight against these devastating conditions that affect many aging individuals.

This nutritional approach opens up possibilities that traditional pharmaceutical approaches have never explored. If you want buy Urolithin A powder/Urolithin A 8-Methyl Ether powder, AASraw maybe good choice.

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