Urolithin B Powder

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Urolithin B Powder Urolithin B Description Urolithin B is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.

Urolithin B also is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates.

Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin B Mechanism of Action It decreases protein degradation and induces muscle hypertrophy.

Urolithin B inhibits the activity of aromatase, an enzyme that interconverts estrogen and testosterone.

Urolithin B is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects.

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Urolithin B Application While studying the anti-inflammatory and antioxidant properties of urolithins A and B, UCL researchers happened to discover that the latter had a protective effect on muscles. ‘Muscle cells in culture that were in contact with urolithin B became larger than those that were not. We wanted to know why.

First, they studied the substance in vitro and found urolithin B has a dual effect: it activates muscle protein synthesis and slows degradation.

Second, the researchers studied the effect of urolithin B in vivo, on mice. ‘It increased their muscle development’, Prof. Francaux says.

‘We also administered it to mice with a severed sciatic nerve resulting in leg paralysis, and the subsequent muscle loss occurred 20 to 30% less quickly and to a lesser extent.’

Effects of Urolithin B Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.

(1). Urolithin B reduces the loss of muscle weight induced by denervation (2). Urolithin B-induced skeletal muscle hypertrophy in mice (3). The anabolic effect of urolithin B is mediated by the androgen receptor (4). Urolithin B stimulates protein synthesis in C2C12 myotubes by activating mTORC1 signalling (5). Urolithin B inhibits protein degradation by downregulating the ubiquitin–proteasome pathway (6). Urolithin B enhances differentiation of C2C12 myotubes

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AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com