AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com Whatisletrozolepowder(Femara)usedfor? 1.HistoryofLetrozole/Femara? Letrozoleisahormonetherapydrugusedtotreatbreastcancerinwomenwhohave gonethroughanaturalmenopause(whenperiodsstop).Itcanalsobeusedin premenopausalwomenhavingovariansuppression(treatmenttostoptheovaries working).Menwithbreastcancermaybegivenletrozole,althoughanotherdrug calledtamoxifenismorecommonlyused.
YoumayalsohearitcalledFemara,whichisitsbest-knownbrandnameTherearea numberofotherbrandsofletrozole,allofwhichcontainthesamedoseofthe LetrozolePowder
Legally,letrozoleisonlyavailablewithadoctor’sprescriptionHowever,thereare websitesthatsellLetrozolePowderonlineandotherperformance-enhancingdrugs. ItisveryconvenientnowtobuyLetrozolePowderonline.Itwillbeimportantto choosethereliablesuppliersuchasAASRAWfactory.
2.WhatisLetrozole(Femara)Powder?
LetrozolePowderisanantiestrogenandoneofthemostpotentAromataseInhibitor. ItiscommonlysoldunderthebrandnameFemaraamongothers.NowItisusedby manybodybuildersduringpostcycletherapy(PCT)andcomplementsotheranabolic steroidsorprohormones.LetrozolePowderhelpsthebodygetbacktoitsnormal stageandstabilizethehormonallevels
3.LetrozolePowdermechanismofaction:Howdoesitwork?
Letrozoleisanaromataseinhibitor,meaningthatitblocksanenzymeresponsiblefor akeystepintheformationofestrogens.Morespecifically,theenzymearomataseis responsiblefortheconversionofandrogens(e.g.,testosterone)intoestrogens.
Letrozoleinhibitsthisprocess,whichreducestheamountofestrogeninthebody.
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com
king@aasraw.com
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com Letrozoleisinmedicationsusedtofightestrogen-dependentbreastcancerinwomen
4.WhatisLetrozolePowderusedfor? LetrozolePowderisusedfortreatingcertaintypeofbreastcanceramong
LetrozolePowderasacrucialPCTsubstance. ①LetrozolePowderisusedfortreatingbreastcancer LetrozolePowderisamedicineusedfortreatingbreastcancerItcanalsohelp preventbreastcancercomingback Itismainlyprescribedforwomenwhohavebeenthroughthemenopauseandhavea typeofcancercalled"hormone-dependent"breastcancer MostpeoplewhotakeLetrozolePowderwillhavehadsurgery,radiotherapyor
LetrozolelowersthelevelsofestrogeninthebodyEstrogensstimulatessome breastcancerstogrowThesebreastcancersarecalledhormonesensitiveor hormonereceptorpositiveBydecreasingtheamountofestrogeninthebody, letrozolecansloworstopthegrowthofsometypesofbreastcancercellsthatneed estrogentogrow.Letrozoleonlyworksinwomenwhohavehadtheirmenopause.
postmenstrualwomen.ItcanbecombinedwithTamoxifen.Itisalsousedtotreat aromatizationissuesintheanabolicsteroidusers.Mostly,anabolicusersconsider
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com sometimeschemotherapytotreattheirbreastcancerfirst LetrozolePowdercomesastabletsMostly,itisavailableonprescriptiononlyDueto
②LetrozoleHelpImproveFertility? AASrawLetrozolePowderhelpstoimprovefertilityintwomainways, (1)inducingovulationand (2)increasingthenumberofeggsreleasedeachcycle. ③FemaraPowdertoInduceandIncreaseOvulation LetrozolePowderencouragestheovariestoovulatebyproducingmorenatural stimulation.FemaraPowderimprovesovulationbyblockingestrogenproduction, whichcausesthebodytoreleasehigherthannormallevelsoffollicle-stimulating hormone(FSH)TheadditionallevelsofFSHstimulateovarianfollicle(s)todevelop andmatureintheovaryForwomenwhodon’tovulateregularlyorwhohave PolycysticOvarianSyndrome(PCOS),theincreasedamountsofFSHcanhelpto producematurefollicle(s)andegg(s),soovulationcanoccur
thepopularityofsteroidpowder,BuyLegalFemaraPowderonlinebecomepossible YoucanselectthereliablesteroidpowdermanfauctureryoulikeJustneedtoensure theysupplythehighqualityproduct.AASRAWisoneofthetopsupplieryoudon’t wanttomiss.StartyourLetrozolepowderPCTcyclefromherewithus.
Forwomenwithoutovulatoryissues,LetrozolePowdercancausethemtodevelop multiplematurefollicles,whichreleasemorethanoneeggsforovulation ResearchhasshownthatAASrawLetrozolePowdercanalsobebeneficialtoinduce ovulationforwomenwhohavepreviouslyfailedwithClomidorareconsidered “ClomidResistant.”Inonestudy,LetrozolePowdersignificantlyhelpedtoimprove ovulationratesandlivebirthratesforwomenwhohavefailedtoovulatewithClomid. ④
LetrozolePowderusesfor(Multiple)EggDevelopment
FemaraPowdercanincreasethenumberofeggsreleasedeachcyclebyincreasing thenumberoffolliclesthatdevelop.Inanormalovulatorycycle,onefollicledevelops, andoneeggisreleased.InaFemaraPowdermedicatedcycle,theamountofFSHa womanproducesincreaseswhichmaycausemultiplefolliclestodevelopand multipleeggstobereleased,especiallyforwomenwhoovulateregularly.The releaseofmultipleeggsgivesabetterchanceforfertilizationtooccur.Medicated cyclesthatresultinthedevelopmentofmultiplefolliclesandeggsarereferredtoas controlledovarianstimulationcycles
AASrawBiochemicalTechnologyCo.,ltd
www.aasraw.com king@aasraw.com
⑤LetrozolePowderusesasPCTinbodybuilding
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com AthleteswhotakeanabolicsteroidsmightuseanaromataseinhibitorlikeLetrozole Powdertopreventtheformationofestrogens,andthereforereduceorpreventthe unwantedandfeminizingeffectsofanabolicsteroiduseTheseFemaraPowderside effectsincludemalebreastdevelopment(gynecomastia),waterretention,andbelly fatInaddition,maleathletesmayuseabusearomataseinhibitorslikeLetrozole Powdertoboosttheirownnaturallevelsoftestosteronebypreventingitsbreakdown. 5.BenefitsOfLetrozolePowderForMen Forsomeuser,LetrozolePowder,Clomid,andNolvadexareacaseofcomparing applesandoranges.Althoughroughlythesamething,thathasdifferenteffects, durations,andoutcomes. lfyou'reconcernedaboutgynospecifically,thenLetrozolePowderwillworkbest.Its nuclearfuelforsteroiduserswhoaresufferingfromgyno,anditcanactuallyreverse thesymptoms SERMsarealsoagreatchoiceforbouncingtestosteronelevelsbackClomidor Nolvadexwillbounceyourlevelsbackbyaround60%frombaselineinaslittleasa monthForgeneralbounceback,thesearebetterthanLetrozolePowder Asabodybuilder,LetrozolePowderbenefitscanbeattractivebecausenotonlydoes
itblockthisconversionandthereforereduceestrogenlevelswhileallowingthe testosteronetorise,butitcanalsopreventwaterretentionwhichwillleadtoaharder, drierlooktoyourmuscletissueRemember,alwaysbuyhighqualityLetrozole Powder,thatisthepreconditiontogetpromisedLetrozolePowderbenefitsithas AASrawLetrozolePowdersupplier,contactusnow Overall,lhadagreatexperienceusingLetrozolePowderusesforPCT,andonline, there'salotofpositivetalkaboutLetrozolePowderbenefitsusingitaswell. Thereisabitofacontradictionthatconfusespeople,inthataromataseinhibitors generallystopconversion,whileSERMsarebetterattargetingestrogenreceptorsin certaintissues,especiallythebreast.Andyet,amongstbodybuilders,AASraw LetrozolePowderisseenasbestforgyno,whenyouwouldthinktheoppositewas trueandthatNolvadex/Clomidwouldbe. lthinkwhatthisismostlyaboutisthatit'ssopotentathigherdoses,thatthegeneral effectsaresostrongtheyshutdownthatgynoprogress,andcanevenreverseit.On theotherhand,NolvadexandClomidcanbepotent,buttheydon'tkickinso aggressivelyandmaintainatthestart,givingtimeforthegynotoprogress 6.WhatarethesideeffectstousingLetrozolePowder?
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com
Headaches HighBloodPressure HotFlashes JointPain Depression LetrozolePowderhasalsobeenshowntohavetheabilitytonotablydecreasebone
ThesideeffectsofLetrozolePowderwillcoverawidebreadthandwillbeverysimilar toArimidexBothweaknessandfatiguearetwoofthemostcommonsideeffectsof LetrozolePowderuseHowever,fortheanabolicsteroiduserthiswillnormallynotbe anissueTheuseofanabolicsteroidsshouldpreventsuchstatessoaslongas estrogensuppressionisn’ttakentoofarTheexceptionwouldbeitsuseduringa hardbodybuildingcontestprepcycle.Duringaharshbodybuildingdiet,theindividual willnormallybeveryweakandfatigueattheendofhisdietduetotremendously intensetrainingandverylowcaloricintake.Beyondpossibleenergyissues,themost commonLetrozolePowderusesideeffectsinclude:
mineralcontent,whichcouldincreasetheriskofosteoporosisThisshould,however, notbeabigriskfortheanabolicsteroidasmoststeroidshavetheabilitytopromote bonemineralcontenttoadegree,especiallyNandrolonepowderAswithall medicationsandanythingweputintoourbody,theLetrozolePowdersideeffectswill largelysurroundpossibleandnotguaranteedWearealldifferentandrespondto
varyingsubstancesdifferentlyThisissomethingyouneedtokeepinmind,andifthe sideeffectsofLetrozolePowderprovetobetoomuchtohandle,alternative medicationsshouldbelookedatBuyhigh-qualityLetrozolePowderwhenever possibletoavoidunwantedLetrozolePowdersideeffects
ThefinalFemaraPowdersideeffectssurroundscholesterol,specificallyareduction inHDLcholesterol.Aloneitdoesnotappeartohaveastrong,statisticalimpact,but fortheanabolicsteroiduserthiscanbeaconcern.Manyanabolicsteroidsalready havetheabilitytonegativelyaffectcholesterol,andwhenconjoinedwithan aromataseInhibitoritappearstobegreatlyexasperated.Studieshaveshownthat therapeuticdosesoftestosteronehaveverylittlenegativeeffectoncholesterolbut thesamedosescansuppressHDLcholesterolbyasmuchas25%whencombined withanaromataseInhibitor.Whentestosteroneisadministeredatasupra physiologicallevel,aminimallevelofHDLsuppressionisnormallyexpected.When thesamedosinglevelisconjoinedwithanaromataseInhibitordatashowsthata 20%orgreatersuppressionofHDLcholesterolisaveryrealpossibility.
Duetothepossibleadverseeffectsoncholesterol,especiallyfortheanabolicsteroid user,acholesterolfriendlylifestylebecomesimperativeAhealthylifestylewillgreatly revolvearoundyourdietSimplesugarsandsaturatedfatsshouldbelimitedand omegafattyacidsshouldbealargepartofyourdietDailyfishoilsupplementationis
AASrawBiochemicalTechnologyCo.,ltd
www.aasraw.com king@aasraw.com
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com recommendedManymayalsofindacholesterolantioxidantsupplementtobeuseful Further,implementingplentyofcardiovascularactivityintoyourroutineisvery importantSometypeofdailycardiovascularactivityisadvised
useSERM’stocombatestrogenicsideeffectswhenpossible.SERM’swon’talways
7.LetrozolePowderDosage TherecommendeddosageforLetrozolePowderdependsonthereasonyou’re takingthisdrugforForinstance,thesuggesteddosageforwomenthattake LetrozolePowderforbreastcanceriscompletelydifferentfromthosewhotakeit purelyasabodybuildingsupplement ①LetrozoleDosageDuringAnabolicSteroidUse MakingthemistakeoftakingtoomuchLetrozolePowderduringsteroidusewillhave nobenefitandbringaboutnegativeeffects,likefatigue,ofcoursebuyhighquality Letrozole(Femara)Powderalsoimportant.Soit’scriticaltomaintainasensible
Becauseofthepotentialcholesterolissues,manybodybuildinguserswillneedto
getthejobdone,buttheycanworkandwillworkalotbetterthanmanysteroidusers believe.IfanaromataseInhibitorisneeded,somehavesuggestedthatadailydose ofNolvadexat10mgperdaywithyouraromataseInhibitorcouldhelpprotect cholesterollevelsduetoSERM’sactivelypromotinghealthiercholesterollevels.
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com
②
Increasedestrogenlevelsisnotanywherenearasgreataconcernforfemalesteroid
competitivebodybuildersorphysiqueathleteswherethisismostimportant
LetrozolePowderdosage Withamedicaldoseusuallyaround25mgdaily,wewouldlookatnohigherthanthat andmostofthetimeevenlowerToprotectfromestrogenrelatedsideeffectsduring steroiduseadoseofaslowas05mgto125mgeverytwodaysisoftenenoughfor excellentestrogenicrelatedprotectionformostmen. Onlyifyouareexperiencingearlysignsofgynecomastiawouldincreasingthedose atthistimeupto2.5mgperdaycanpotentiallyevenfullyreversethesymptoms;but bepreparedforanoticeablezapinenergyduringthistime.Oncegynosymptoms subsideit’simportanttoreduceyourLetrozolePowderdosagebackdowntoregular estrogenicprotectionlevels.
FemaleLetrozolePowderdosage
usersasitisformales.ThemainreasonforusinganaromataseInhibitorlike LetrozolePowderbyfemaleswouldbetomitigatewaterretention,especiallyfor
InfactLetrozolePowderisnotrecommendedasafirstchoiceforfemalesduetoits potencyinreducingestrogensomuch,hencewhyitisnotusedmedicallybyfemales whohavenotgonethroughmenopauseFemaleswhoaredeterminedtouse
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com LetrozolePowderareadvisedtodoseatjust05mgeveryotherdayandgauge resultsandeffectsfromthere 8.Whomightbeofferedletrozole(Femara)Powder?
9.LetrozolePowdervsArimidexforPCT
cost,andwantingtofollowinthepathofwhatfriendsandonlineacquaintances
LetrozolePowderissuitableforwomenwhohavebeenthroughthemenopauseand whosebreastcancerisoestrogenreceptorpositive. SometimesFemaraPowderisgivenalongsideovariansuppressiontowomenwho haven’tyetbeenthroughthemenopause. Ifyourcancerishormonereceptornegative,thenLetrozolePowderwillnotbeofany benefit.
LetrozolePowderandArimidexpowderareverysimilarcompoundsBothare nonsteroidalaromataseinhibitorsandbotharefavoredbyanabolicsteroidusersto preventestrogenicsideeffects.Bothdrugshaveasimilarsideeffectriskprofile.Out ofthethesetwoAIs,Arimidexgenerallytakestheleadasbeingmorewidelyusedby bodybuildersbutthiscancomedowntoanumberoffactorsincludingavailability,
mightrecommend
WhilebothoftheseAIscanhelpstimulatenaturaltestosteroneproduction,neither areconsideredbymostguystobetherightchoiceforPCTwhenusedalone;infact manypeoplewon’tuseapowerfulAIlikeArimidexorLetrozolePowderduringPCT atallandinsteadgoforaSERMdrugwithNolvadexbeingapopularchoice, alongsideClomidandoftenHCGaswell. ThemainreasonforthisisthatArimidexpowderisverygoodatloweringestrogen, andAASrawLetrozolePowderevenmoreso.Theyaresopowerfulatthistaskthat theycanresultinestrogenlevelsthataretoolowevenforthemalebody.Buy LetrozolePowderwholesalefromAASrawsupplier,enjoythebulkprice. Thiscausescomplicationsinthehormonalbalanceandwillhaveanegativeimpact inyournaturaltestosteronerecovery;malesstillneedasmallamountofestrogento keepthingsinbalanceandsincePCTisallaboutgettingyournaturalhormone functionbacktonormal,continuingwithahighestrogensuppressiondruglike LetrozolePowderorArimidexafterthesteroidcyclecanmakethisdifficult,ifnot impossible
AnotherissuewhenconsideringtheuseofLetrozolePowderduringPCTisthat whenitiscombinedwiththestaplePCTdrugofchoiceformostpeople,Nolvadex,a
AASrawBiochemicalTechnologyCo.,ltd
www.aasraw.com king@aasraw.com
negativeinteractionoccurswheretheconcentrationsofdrugscounteracteachother ThisisalsoanissuewhenArimidexiscombinedwithNolvadex ThisisanotherreasonwhycombiningeitheroftheseAIswithaSERMduringPCTis notadvisableatall–andsinceaSERMisbasicallyessentialforPCTitisgoingto takepriorityovereitherLetrozolePowderorArimidex.BothoftheseAIsofferfar moreadvantageswhentheiruseislimitedtoduringyoursteroidcyclewhereyoucan greatlybenefitfromtheirpowerfulantiestrogeneffectsduringthattime.
10.LetrozoleVSclomid
Clomid(clomiphenecitrate)powderisanotherdrugoftenusedbysteroidusers. UnlikeLetrozolePowderwhichisanaromataseinhibitor,Clomidisaselective estrogenreceptormodulator(SERM).Bothdrugsareveryeffectivebuttheywork differently,soonecannotbesaidtobebetterthantheother Ifyouwantanaromataseinhibitor,LetrozolePowderispossiblythebestat controllingestrogensymptomswhileyou’reonasteroidcyclewhileClomidisa standardchoiceforPCTuseLetrozolePowderiseffectiveatloweringoverall estrogensoisexcellentforbothwaterretentioncontrolandgyno,whileClomid specificallytargetsthebreasttissue.
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com ForPCTusage,Clomidisconsideredabetterchoicebecauseitdoesnotsuppress overallestrogenlevelsthewaythatLetrozoledoeswhichprovidesabetterhormonal balanceforrestoringyournormaltestosteroneproductionafterasteroidcycleBy comparison,LetrozolePowderisgenerallyconsideredtoopowerfulasanestrogen reductiondrugtobeagoodchoiceforPCT 11.BuyingLetrozolePowdertouseasapctsupplement LetrozolePowdercanbeboughtonline,inthesamewayasSARMsandgeneric Nolvadex/Clomid. Theproblemisalwaysthesamethough.Youneedtofindanreliablesupplierthat sellsthesechemicalswithpurityguarantees. AASrawsuppliesgeniussteroidrawpowderandPCTsupplements,youcanget everythingyouneedatthesametimeinoneorderBuyLetrozolePowderbulkwill getwholesaleprice 12.References [1]LeeVC,GaoJ,LeeKF,etal.Theeffectofletrozolewithmisoprostolformedical terminationofpregnancyontheexpressionofsteroidreceptorsintheplacenta.Hum
Reprod2013Nov;28(11):2912-9PMID:23980056
[2]TomaoF,SpinelliG,ViciP,etalCurrentroleandsafetyprofileofaromatase inhibitorsinearlybreastcancerExpertRevAnticancerTher2011 Aug;11(8):1253-63PMID:21916579
[3]YapuraJ,MapletoftRJ,PiersonR,etal.Abovinemodelforexaminingtheeffects ofanaromataseinhibitoronovarianfunctioninwomen.FertilSteril.2011 Aug;96(2):434438.e3.PMID:21696721. [4]Pharmacologyandpharmacokineticsofthenewergenerationaromatase inhibitors.BuzdarAU.ClinCancerRes.2003Jan;9(1Pt2):468S72S. [5]Aromataseoverexpressiontransgenicmicemodel:celltypespecificexpression anduseofletrozoletoabrogatemammaryhyperplasiawithoutaffectingnormal physiology.MandavaU,KirmaN,TekmalRR.JSteroidBiochemMolBiol.2001 Dec;79(1-5):27-34.
AASrawBiochemicalTechnologyCo.,ltd
www.aasraw.com king@aasraw.com
[6]“DangersofExcessEstrogenIntheAgingMale”Faloon,WilliamLifeExtension Magazine,November2008 [7]Aromataseinhibition,testosterone,andseizuresHardenC,MacLuskyNJ
AASrawBiochemicalTechnologyCo.,ltd www.aasraw.com king@aasraw.com
EpilepsyBehav2004Apr;5(2):260-3 [8]Comparativeclinicalpharmacologyandpharmacokineticinteractionsof aromataseinhibitorsBoeddinghausIM,DowsettMJSteroidBiochemMolBiol 2001Dec;79(1-5):85-91 [9]Inhibitoryeffectofcombinedtreatmentwiththearomataseinhibitorexemestane andtamoxifenonDMBAinducedmammarytumorsinrats. [10]Pharmacologyandpharmacokineticsofthenewergenerationaromatase inhibitors.BuzdarAU.ClinCancerRes.2003Jan;9(1Pt2):468S72S.
