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What is Nicotinamide Mononucleotide(NMN)?
Nicotinamide Mononucleotide (CAS:1094-61-7), also called NMN, which is a naturally occurring compound that is in small amounts in the human body as well as some foods. NMN is orally bioavailable, and when taken orally can support NAD+ levels within liver and muscle tissue. Recent research has suggested that NMN may support cardiovascular health, energy production, cognitive health, and well as retinal and bone health. One especially interesting finding of NMN research is that it may promote DNA repair and support the activation of the SIRTUIN genes which are thought to play a role in healthy aging.
※ How is NMN Synthesized In the Body? NMN is produced from B vitamins in the body. The enzyme responsible for making NMN in the body is called nicotinamide phosphoribosyltransferase (NAMPT). NAMPT attaches nicotinamide (a vitamin B3) to a sugar phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate). NMN can also be made from ‘nicotinamide riboside’ (NR) through the addition of a phosphate group. ‘NAMPT’ is the rate-limiting enzyme in the production of NAD+. This means lower levels of NAMPT cause decreased NMN production, resulting in decreased NAD+ levels. Adding precursor molecules like NMN can also speed up NAD+ production.
Potential Benefits of NMN Once inside an animal’s cells, NMN feeds into the production of NAD+, which provides cells with needed energy and is thought to be critical for healthy aging. NAD+ also plays a key role in activating proteins that maintain the integrity of our DNA. Given its central role in so many cellular processes, the potential benefits of NMN extend to nearly all body systems. Below are some of the better-known examples. 1
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❶ Promotes Vascular Health and Blood Flow We rely on our skeletal muscles for movement, stability and strength. To remain strong and in good condition, these muscles must consume significant amounts of key energy molecules, like glucose and fatty acids. Because NAD+ is required to metabolize these molecules, our muscles need a steady supply of its building blocks, such as NMN. Studies in mice have shown that NMN protects against numerous aging-related declines in health, such as the stiffening of blood vessels, oxidative stress, our cells’ ability to keep dividing, and even changes in how active our genes are, what scientists call gene expression.
❷ Improves Muscle Endurance and Strength Studies have shown that mice fed NMN for extended periods of time had better energy metabolism with no obvious side effects. The health of our muscles grows ever more important as we age and our own supply of NAD+ declines.
❸ Protects Against Heart Disease At least your skeletal muscles get to take breaks. Not only can your heart not take a rest, it can’t even slow its pace much without causing serious problems. The heart’s energy requirement, therefore, is tremendous. And to keep it ticking, it needs to make all the NAD+ it can. This is why cardiac cells need a steady supply of NMN.
❹ Lowers Risk of Obesity Obesity is linked to a wide array of unhealthy conditions and can be very challenging to treat. There is no easy remedy for obesity and related conditions such as diabetes and metabolic syndrome. While lifestyle adjustments like consistent exercise and a healthy diet are of paramount importance, every little bit helps. In mouse studies, NMN displays an effect that mimics aspects of calorie restriction (CR). Although CR has been shown to provide numerous benefits to aging and health, it is a 2
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difficult regime to maintain over a long period of time. Mimicking its benefits without adhering to such an extreme diet would be undeniably beneficial.
AASraw is the professional manufacturer of NAD+ & NMN as Supplement. ❺ Enhances Maintenance of DNA Repair The NAD+ made from NMN activates a group of proteins called sirtuins. Sirtuins, sometimes thought of as the guardians of our healthspan, play a key role in maintaining DNA integrity. Each time our cells divide, the DNA at the very ends of our chromosomes grows a tiny bit shorter. At a certain point, this begins to damage our genes. Sirtuins slow this process by stabilizing those end bits, known scientifically as telomeres. In order to function, however, sirtuins rely upon NAD+. Recent studies have shown that feeding mice NMN activated sirtuins and led to more stable telomeres.
❻ Increases Mitochondrial Function Simply put, we couldn’t live without our mitochondria. These unique cellular structures are known as the powerhouses of the cell. They convert molecules from the food we eat into the energy that our cells use. NAD+ is central to this process. In fact, mitochondrial anomalies caused by the loss of NAD+ may even impact neurological disorders such as Alzheimer’s. Studies done in mice have shown that NMN supplementation has rescued some mitochondrial dysfunctions.
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