Genomics

Topological Data Analysis for Genomics and Evolution Topology in Biology

Raul Rabadan

Columbia University, New York

and Andrew J. Blumberg

University of Texas, Austin Algebraic topology is particularly suited for the analysis of high dimensional large data sets, including those in modern biology. The book introduces geometric and topological methods, including statistics, as well as applications to biology – including cancer genetics, single cell studies and reconstructing evolutionary relationships from genomic data. Contents: Part I. Topological Data Analysis; Part II. Biological Applications.

‘The time is right to bring new approaches to the analysis of biological data. Topological data analysis reveals the structure of data. This book shows how algebraic topology opens new doors, presenting ideas and directions that make testable predictions and explore life processes.’

Arnold J. Levine, Institute for Advanced Study, New Jersey

‘This fascinating book describes how advances in mathematics, especially in fields such as topology, are transforming our understanding of biology. Rabadan, one of the founders of the field, shows us how the evolution of cancer, and of viruses and bacteria, can be deeply understood through these novel mathematical techniques. Rabadan’s capacity to create a synthesis of many threads, and lay out future challenges, makes this an intriguing and compelling read.’

Siddhartha Mukherjee, Columbia University Medical Center, New York and author of The Gene: An Intimate History and The Emperor of All Maladies: A Biography of Cancer

2019 247 x 174 mm 324pp 277 colour illus. 978-1-107-15954-9 Hardback £39.99 / US$49.99 For all formats available, see www.cambridge.org/9781107159549

Genome Editing and Engineering From TALENs, ZFNs and CRISPRs to Molecular Surgery

Edited by Krishnarao Appasani

GeneExpression Systems, Inc.

Foreword by George M. Church

Endonuclease-based genomic engineering is a field with broad potential applications for the treatment of human disease. This complete reference covers the discovery, basic science and application, making it invaluable for researchers and graduate students across the biomedical sciences, and those in the biotechnology and pharmaceutical industries. Contents: Part I. Biology of Endonucleases (Zinc-Finger Nuclease, TALENs and CRISPRs) and Regulatory Networks; Part II. Genome Editing in Model Organisms; Part III. Technology Development and Screening; Part IV. Genome Editing in Stem Cells and Regenerative Biology; Part V. Genome Editing in Disease Biology; Part VI. Legal (Intelluctual Property) and Bioethical Issues of Genome Editing.

‘This comprehensive book is welcome at this point of rapid growth in new technologies and discoveries such that keeping up with applications of genome engineering is challenging. Here we have both a general introduction to the field and to deep mechanisms and glimpses of future applications and ethical considerations – with gems for newcomers and experts alike.’

George M. Church, Harvard University, Massachusetts and Massachusetts Institute of Technology

‘Krishnarao Appasani has assembled a comprehensive series of up-to-date chapters on endonuclease-based genomic engineering by experts and practitioners. The book presents a wide range of topics from basic science, applications to genetic screens and diseases, and legal and ethical issues. The many potential applications across a wide range of organisms are well illustrated. The book will become a must have for any researchers in academia and industry trying to keep up with this fast-moving field.’

Norbert Perrimon, Harvard Medical School, Boston

2018 247 x 174 mm 498pp 122 b/w illus. 32 colour illus. 9 tables 978-1-107-17037-7 Hardback £130.00 / US$170.00 For all formats available, see www.cambridge.org/9781107170377

Genome-Wide Association Studies From Polymorphism to Personalized Medicine

Edited by Krishnarao Appasani

GeneExpression Systems, Inc., Massachusetts

Foreword by Stephen W. Scherer

University of Toronto

and Peter M. Visscher

University of Queensland Genome-wide association studies (GWAS) will have increasing importance in the post-genomic era. This timely publication, written by leading experts from academia and industry, provides an essential overview for both established scientists and students, focusing on the use of GWAS in the context of disease biology and personalized medicine. Contents: Part I. Genome-Wide Association Studies; Part II. Genome-Wide Studies in Disease Biology; Part III. Single Nucleotide Polymorphisms, Copy Number Variants, Haplotypes and eQTLs; Part IV. Next-Generation Sequencing Technology and Pharmacogenomics; Part V. Population Genetics and Personalized Medicine.

‘Genome-Wide Association Studies: From Polymorphism to Personalized Medicine, edited by Krishnarao Appasani, summarizes most elegantly the contributions of GWAS as a major discovery tool linking complex disease phenotypes to genetic variants and associated biological pathways and gene networks that were previously unknown. GWAS has transformed the genetic landscape in complex disease and has informed us more about the genetic underpinnings of common diseases and pharmacogenomics traits than any other tool to date. The present book captures this development elegantly and is a pleasure to read.’

Hakon Hakonarson, University of Pennsylvania

‘From genotype to phenotype: this biological paradigm is now elucidated and extended to the vision of genomic medicine. This highly informative book combines the current knowledge of genome wide association studies with the pathophysiology, epidemiology of human disease, and health condition, especially, implicating in the development of personalized and precision medicine. The combination of technical, scientific, medical, and pharmaco-economic aspects supports the high value of this book for scientists and medical specialists working in the field.’

Christine Günther, Chief Executive Officer, apceth GmbH and Co. KG, Munich, Germany

2016 247 x 174 mm 432pp 67 b/w illus. 26 colour illus. 24 tables 978-1-107-04276-6 Hardback £127.00 / US$204.00 For all formats available, see www.cambridge.org/9781107042766