Of related interest

Single-Molecule Science From Super-Resolution Microscopy to DNA Mapping and Diagnostics

Edited by Krishnarao Appasani

GeneExpression Systems, Inc.

and Raghu Kiran Appasani

University of Southern California Keck School of Medicine Bridging biophysics and molecular imaging, this authoritative text guides readers through the use of single molecule approaches in the study of molecular nanomachines, protein folding, biological assemblies, gene expression, and DNA mapping for diagnostic purposes. A must-have for researchers, graduate students, and those working in the industry. 2020 247 x 174 mm c.550pp 34 b/w illus. 1 table 978-1-108-42336-6 Hardback c. £125.00 / c. US$159.99

Publication August 2020

For all formats available, see www.cambridge.org/9781108423366 Optogenetics From Neuronal Function to Mapping and Disease Biology

Edited by Krishnarao Appasani

GeneExpression Systems, Inc., Massachusetts Optogenetics – a revolutionary technique combining genetic and optical methods to observe and control the function of neurons – has huge potential, with applications from brain circuits and sleep to neurodegenerative and neuropsychiatric diseases. This book is a reference for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries. Contents: Part I. Optogenetics in Model Organisms; Part II. Opsin Biology, Tools and Technology Platform; Part III. Optogenetics in Neurobiology, Brain Circuits and Plasticity; Part IV. Optogenetics in Learning, Neuro-psychiatric Diseases and Behavior; Part V. Optogenetics in Vision Restoration and Memory; Part VI. Optogenetics in Sleep, Prosthetics and Epigenetics of Neurodegenerative Diseases.

‘Optogenetics has transformed neuroscience and has become a key element of the toolkit used by thousands of labs worldwide. If anyone needs convincing that the field of optogenetics has come of age, this book provides compelling evidence. Written by leading experts in the field and covering the gamut of optogenetics research from tool development and use in basic research through to translational applications, Optogenetics exemplifies how this technique now illuminates all areas of neuroscience research.’

Michael Hausser, University College London,

‘’Let there be light’. Or more precisely, deliver the needed wavelength at appropriate power, with high temporal and spatial resolution if you want to figure out how brain circuits work. This volume has many excellent chapters and the right toolbox for the job.’

György Buzsáki, Neuroscience Institute and Langone Medical Center, New York University

2017 247 x 174 mm 502pp 65 b/w illus. 37 colour illus. 6 tables 978-1-107-05301-4 Hardback £131.00 / US$184.00 For all formats available, see www.cambridge.org/9781107053014

HIGHLIGHT

Understanding Coronavirus

Raul Rabadan

Columbia University, New York Why is the information available about the coronavirus/COVID-19 so confusing? Written by a leading researcher, Understanding Coronavirus is a concise and accessible introduction to all the science and facts you need to understand how the virus works, how it spreads and how it compares to other respiratory viruses.

‘With all the technology and medical knowledge of the 21st century a pandemic virus has defeated us. This book tells us why and how that could happen and what we can do about it. And as a bonus we get a comparison with the 1918 pandemic Flu. All this wrapped up in a clear, understandable and interesting way. We learn what is happening to us now and how to better prepare for the future.’

Arnold J. Levine, Institute for Advanced Study, Princeton, New Jersey

‘An extremely concise and important book that everyone should read to understand the dynamics of the COVID-19 pandemic.’

Siddhartha Mukherjee, Columbia University, New York, and author of The Gene and The Emperor of All Maladies

‘Raul Rabadan has written an essential book for the first pandemic of the 21st century, COVID19 caused by SARS-CoV-2. It’s a wonderfully concise and accessible explanation of everything you want to know about the virus, the disease, and the outbreak. If you want to learn what is a coronavirus, how the outbreak started, what are the therapeutic options, and much more, I highly recommend this book. Professor Rabadan explains viruses in a way that is accessible to all.’

Vincent Racaniello, Columbia University, New York

Understanding Life

2020 178 x 127 mm c.120pp 978-1-108-82671-6 Paperback £9.99 / US$11.99 For all formats available, see www.cambridge.org/9781108826716

Understanding Evolution Second edition

Kostas Kampourakis

University of Geneva What is evolution and why do so many people find it difficult to understand? Understanding Evolution is a concise and accessible introduction to the core concepts of evolutionary theory, presented in the light of common conceptual obstacles. It shows that there is more than religious resistance to accepting evolution.

‘While other books explain what is wrong with the popular attacks on evolution – e.g. creationism, or Intelligent Design – this concise book addresses the fundamental question: why do people fail to accept evolution? This is like going deep to the causes of the illness, while others just try to lower the fever.’

Alessandro Minelli, University of Padova, Italy, and author of Plant Evolutionary Developmental Biology

‘A well-known philosopher of biology once wrote that evolutionary theory seems so simple that almost anyone can misunderstand it. In this heartfelt yet thoughtful book, Kostas Kampourakis essentially turns that sentiment on its head.’

John C. Avise, Distinguished Professor of Ecology and Evolution, University of California–Irvine, and author of Evolutionary Pathways in Nature: A Phylogenetic Approach.

Understanding Life

2020 178 x 127 mm c.300pp 7 tables 978-1-108-74608-3 Paperback £12.00 / US$14.95

Publication August 2020

For all formats available, see www.cambridge.org/9781108746083 Philosophy of Science for Biologists

Edited by Kostas Kampourakis

Université de Genève

and Tobias Uller

Lunds Universitet, Sweden Written for students and researchers in the life sciences, this is the first book to provide an accessible introduction to philosophy of science with a focus on biology. It draws on contemporary examples to enable biologists to become more philosophically minded and informed, facilitating all aspects of research and communication.

‘As a philosopher and a biologist I have been waiting for a long time for a book like this to come out. My students will learn a lot from it.’

Massimo Pigliucci, K.D. Irani Professor of Philosophy, City College of New York

‘ Philosophy of Science for Biologists is a muchawaited book written for biologists, mainly for curious and open-minded biology students. Presenting a broad spectrum of perspectives and many fascinating examples from all areas of biology, the fifteen essays in this book offer a broad and exciting vista of biological ideas, their scope, their ambitions and their potential prejudices. The essays illustrate how a multiplicity of perspectives and methodologies can be combined to answer difficult questions, encouraging cooperation, healthy skepticism and necessary optimism. It should be the basis of an obligatory course for all biology students.’

Eva Jablonka, Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv University

2020 244 x 170 mm c.275pp 1 b/w illus. 2 tables 978-1-108-74070-8 Paperback £26.99 / US$34.99

Publication July 2020

For all formats available, see www.cambridge.org/9781108740708

Prokaryotic Metabolism and Physiology Second edition

Byung Hong Kim

Korea Institute of Science and Technology, Seoul

and Geoffrey Michael Gadd

University of Dundee Our biosphere is shaped by vast numbers of different prokaryotic microorganisms which show extremely diverse metabolic capabilities. This book provides an up-to-date overview of the metabolic processes that occur in bacteria and archaea, and the key processes that determine their roles in the environment, biotechnology and human health.

‘Overall this is an excellent text for researchers to refer to and for more advanced students to understand the complexities that are presented by prokaryotic organisms.’

Ellis O’Neill, The Biologist

2019 246 x 189 mm 504pp 373 b/w illus. 60 tables 978-1-107-17173-2 Hardback £130.00 / US$175.00 978-1-316-62291-9 Paperback £49.99 / US$69.99 For all formats available, see www.cambridge.org/9781107171732

NEW IN PAPERBACK

Fred Sanger – Double Nobel Laureate A Biography

George G. Brownlee

University of Oxford

Foreword by Edwin Southern

University of Oxford Drawing, in part, on a rare interview by the author, this is the first full biography of Fred Sanger to be published. Brownlee highlights the remarkable extent of Sanger’s scientific achievements, providing a real portrait of the man behind them and considering his continuing legacy as ‘the father of genomics’.

‘Fred Sanger’s innovation and achievements enabled us to read the code of life. His breakthroughs transformed science, medicine, industry and society, and continue to open our eyes to a new knowledge and understanding of how life works … This book provides a rare opportunity to see a glimpse of a remarkable man who changed the world.’

David Bentley, Vice-President and chief scientist, Illumina Inc., Cambridge

‘Every student of molecular biology would profit greatly by lingering over Sanger’s own descriptions of the several strategies he attempted and the tools he had to invent to arrive at what is referred to today as Sanger DNA Sequencing … Sanger’s success transformed molecular biology in inestimable ways and his methodology is equally foundational in such varied fields as evolutionary biology, plant breeding, paleontology, anthropology, linguistics, forensics and computer science … Fred Sanger was motivated by the challenge of discovery and believed fervently that through art and science, in their broadest senses, it is possible to make a lasting contribution towards the improvement and enrichment of human life.’

Paul Berg, Stanford University, California

2020 229 x 152 mm c.224pp 94 b/w illus. 8 colour illus. 978-1-108-79453-4 Paperback £18.99 / US$24.99 For all formats available, see www.cambridge.org/9781108794534

Wilson and Walker’s Principles and Techniques of Biochemistry and Molecular Biology Eighth edition

Edited by Andreas Hofmann

Griffith University, Queensland

and Samuel Clokie

Birmingham Women’s and Children’s Hospital This best-selling undergraduate textbook introduces the key experimental techniques from across the biosciences. It uniquely integrates the theories and methods driving the fields of biology and medicine, comprehensively covering both the techniques that students will encounter in lab classes and those that underpin recent advances and discoveries.

‘After seven editions between 1975 and 2010 this essential textbook has undergone a major update. The new editors, Drs Hofmann and Clokie, recruited many experts to revise individual chapters and added a significant amount of new material, thus making the book even more valuable. This eighth edition is basically a new book that covers the techniques of biochemistry and molecular biology in a very comprehensive manner – it does not go into great detail, but gives the reader a good introduction to all of them. Each chapter contains suggestions for further reading for those in need of a follow-up. Excellent diagrams and illustrations provide help in comprehension of the presented material. Since this text is largely aimed at undergraduate students, it fulfils its role extremely well.’

Alexander Wlodawer, National Cancer Institute at Frederick

Review from previous edition: ‘This book deserves a place in any modern pathology department and brings together a body of information which is traditionally scattered across several texts … it also represents excellent value for money.’

Annals of Clinical Biochemistry

2018 247 x 174 mm 956pp 374 colour illus. 978-1-107-16227-3 Hardback £117.00 / US$152.99 978-1-316-61476-1 Paperback £39.99 / US$51.99 For all formats available, see www.cambridge.org/9781107162273 Leading your Research Team in Science

Ritsert C. Jansen

Rijksuniversiteit Groningen, The Netherlands This short and practical guide offers valuable recommendations, stories and exercises, to guide readers towards a really successful career as an independent investigator in science. A must-read for earlycareer researchers, as well as those advising them and anyone else serious about science. This title is available as Open Access via Cambridge Core. Contents: Part I. Team; Part II. Organization; Part III. Society. 2018 228 x 152 mm 230pp 21 b/w illus. 978-1-108-70186-0 Paperback £18.99 / US$24.99 For all formats available, see www.cambridge.org/9781108701860

Funding your Career in Science From Research Idea to Personal Grant

Ritsert C. Jansen

Rijksuniversiteit Groningen, The Netherlands How can you get the funding to establish or consolidate a career in science? This concise guide offers step-by-step advice, real-life stories and practical exercises to help you prepare effective career grant applications and optimise your funding opportunities. A must-read for students, postdocs, professors, and anyone else serious about science.

‘This is a well-written text for the purposes of enlightening the readership on proposal writing. I highly recommend it for use by those in the early stages of seeking funding for their careers in science and engineering.’

IEEE Pulse

‘… a practical guide aimed primarily at early career academics considering the major challenge of writing applications for project grant and fellowship funding. With success rates for proposals reduced to an all-time low, help on how to be competitive is precious … strongly recommended if you are a postgraduate biology student, postdoc or young group leader.’

Andrew Taylor-Robinson, The Biologist

2013 228 x 152 mm 215pp 15 b/w illus. 978-1-107-62417-7 Paperback £18.99 / US$28.99 For all formats available, see www.cambridge.org/9781107624177 Developing a Talent for Science

Ritsert C. Jansen

Rijksuniversiteit Groningen, The Netherlands How can you make the most of your talent for science? This practical guide offers valuable recommendations, real-life stories and practical exercises to enable students, postdoctorates and professors to develop their skills and succeed in academia, industry or elsewhere.

‘This insightful book offers guidance toward an enhanced productive academic or professional scientific career … a must-read for any professional in the geophysical community and for those pursuing studies in this field.’

The Leading Edge

‘… if you had only one book to recommend to a student I would suggest this one. It is all there: the tips that, if applied, will make you a good presenter, an inspiring communicator, a soughtafter collaborator, and more.’

Elements

2011 228 x 152 mm 180pp 20 b/w illus. 978-0-521-14961-7 Paperback £18.99 / US$28.99 For all formats available, see www.cambridge.org/9780521149617

Modern Prometheus Editing the Human Genome with Crispr-Cas9

Jim Kozubek

Massachusetts Institute of Technology Would you change your genes if you could? Crispr-Cas9 technologies are now offering cheap and effective methods for editing the human genome. Telling the interwoven stories of the scientists involved, Kozubek traces events across a fifty-year period, demystifying how Crispr works and reflecting on the continuing ethical dilemmas it brings, detailing all the very latest in this updated paperback edition. 2018 228 x 152 mm 474pp 978-1-108-45462-9 Paperback £14.99 / US$19.95 For all formats available, see www.cambridge.org/9781108454629

The Cell as a Machine

Michael Sheetz

Columbia University, New York

and Hanry Yu

National University of Singapore Connecting underlying theory with real-world applications, this systematic and mathematically accessible textbook explains cell functions using the engineering principles of robust devices. It is ideal for undergraduate and graduate students taking singlesemester courses in cell mechanics, biophysics and cell biology. Contents: Part I. Principle of Complex Function in Robust Machines; Part II. Design and Operation of Complex Functions; Part III. Coordination of Complex Functions.

Cambridge Texts in Biomedical Engineering

2018 246 x 189 mm 434pp 2 b/w illus. 136 colour illus. 978-1-107-05273-4 Hardback £69.99 / US$91.99 For all formats available, see www.cambridge.org/9781107052734

Biophysics of DNA

Alexander Vologodskii

New York University Designed to enable students and researchers of molecular biology, biochemistry and physics to better understand the biophysics of DNA, this text surveys the very latest research. The author integrates theoretical and experimental approaches, emphasizing the importance of quantitative knowledge of physical properties in building and analyzing models of DNA functioning. 2015 247 x 174 mm 272pp 155 b/w illus. 16 colour illus. 9 tables 978-1-107-03493-8 Hardback £75.00 / US$99.99 For all formats available, see www.cambridge.org/9781107034938

Aaron Klug – A Long Way from Durban A Biography

Kenneth C. Holmes

Max-Planck-Institut für Medizinische Forschung, Heidelberg A Nobel prize winner and pioneer of structural molecular biology, Aaron Klug served as Director of the Laboratory of Molecular Biology and President of the Royal Society. Holmes draws on their long-term collaboration, interviews and unique access to Klug’s archives to illuminate both his personal life and significant scientific achievements. Contents: Part I. From Durban to Birkbeck College; Part II. Science at the Laboratory of Molecular Biology; Part III. Duties and Rewards.

‘This biography highlights both the sense in which Klug was self-made and driven, and the importance of his collaborations, mentors, peers and his own students in shaping the man he became and his intellectual achievements. The biography also offers a fascinating insight into macromolecular scientific discovery while keeping a very human touch throughout. A fitting tribute to a great scientist and role model.’

Max Price, University of Cape Town

‘Kenneth C. Holmes’ lively biography of Aaron Klug narrates the fascinating story of a man who had a central role in the transformation of modern biology into a molecular science. Holmes embeds Klug’s scientific innovations in the wider context of mid-to-late twentieth-century intellectual and social history; his descriptions of the left-wing Zionism of Klug’s youth in South Africa and of the machinations of reactionary dons in Peterhouse, Cambridge, have the same absorbing clarity as his explanations of how Klug and his co-workers created a science of quantitative image analysis in electron microscopy. At once a vade mecum to structural biology and a document of the postwar academic scene in Britain, this book is also quite simply a very good read.’

Stephen Harrison, Harvard University

2017 228 x 152 mm 378pp 60 b/w illus. 13 colour illus. 978-1-107-14737-9 Hardback £29.99 / US$44.99 For all formats available, see www.cambridge.org/9781107147379