Paediatrics annualreport 2013

Department of Paediatrics

Annual Report Serving Today and Building Foundations for the Future

February 2014 This reports includes data and events from the calendar year 2013, and academic year July 2012 â&#x20AC;&#x201C; June 2013 Respectfully submitted by: James D. Kellner MD, FRCPC Professor and Head, Department of Paediatrics, University of Calgary and Alberta Health Services â&#x20AC;&#x201C; Calgary Zone

Table of Contents

2 5

Introduction

Vission, Mission, Values

Rheumatology

verview of O Clinical Sections and Divisions and Research Units

Research Methods Team Sleep-Epilepsy Research Project

SECTIONS

Paediatric Update Conference Cardiology Community Peadiatrics Critical Care

9 10

escription D of Department Members

Zone Paediatric Executive Committee 2013 Admin, Support and Research Staff

Endocrinology Gastroenterology

Paediatric Clinical Activity in Calgary Zone Facilities

Overview

Hospital Pediatrics

Undergraduate Medical Education (UME)

KidSIMâ&#x201E;˘ Pediatric Simulation Infectious Diseases Medical Genetics Neonatology ACH Neonatal Intensive Care Unit (NICU) update | November 2013 Nephrology Transition Symposium Neurology

Post Graduate MEdical Education (PGME) P GME Programs and Trainees G eneral Paediatrics

Awards and Recognitions Mission Possible App

99 103

New Department Faculty Members Research Funding

Medical Genetics Neurology Developmental Paediatrics Emergency Medicine

Oncology

Endocrinology

Palliative Medicine

Gastroenterology

Respiratory

Hematology

Asthma Program

Mentorship Program

Education and Training Programs

Hematology

Calgary Childhood Traumatic Brain Injury Program

Annual Report 2013 | Department of Paediatrics

P aediatric Simulation Education

Emergency Medicine Paediatric Emergency Medicine at the South Health Campus

CME U ndergraduate Health Sciences

Dr. Suzanne Tough

Developmental Peadiatrics

Respiratory Medicine Continuing Medical Education (CME)

Global Child Health Unit

PROGUT

epartment D Organization and Leadership

Nephrology

Behavioural Research Unit

Adolescent Medicine

Neonatal/Perinatial

RESEARCH UNITS

119

eer-Reviewed P Research Publications

Infectious Diseases

Introduction

Welcome to the combined academic and clinical Department of Paediatrics for the University of Calgary and Alberta Health Services â&#x20AC;&#x201C; Calgary Zone.

ucalgary.ca/paed/

Department of Paediatrics | Annual Report 2013

The Department has four fundamental activities: 1. Provision of all levels of clinical services to infants, children and adolescents in Calgary, throughout Alberta and other provinces; 2. Training the next generation of healthcare professionals caring for children and their families, and continued training for current healthcare professionals; 3. Knowledge generation and innovation in clinical care and education through the conduct, dissemination and translation of research; 4. Provision of leadership throughout clinical and academic health systems. We have grown to over 300 clinical and academic faculty members in 20 clinical sections and divisions, and 2 academic units. The hub of our clinical services is the 135 bed Alberta Children’s Hospital (www.albertahealthservices.ca/ facilities.asp?pid=facility&rid=1010904) which last year (2012-13) received over 296,000 outpatient clinic visits, nearly 73,000 emergency department visits and nearly 7900 admissions. We provide neonatal intensive care unit (NICU) care at the Alberta Children’s Hospital, Foothills Medical Centre, Peter Lougheed Centre, Rockyview General Hospital and, since the autumn of 2013, the new South Health Campus. Last year, over 3000 babies were admitted

Annual Report 2013 | Department of Paediatrics

to our NICUs. We also provide paediatric inpatient service at the Peter Lougheed Centre (with over 1200 admissions in 2012-13), as well as general paediatric and subspecialty ambulatory clinical services throughout Calgary. We provide palliative and respite care at the Rotary Flames House, located beside ACH. Our physicians travel to provide hundreds of outreach clinics throughout southern Alberta. The population we serve continues to grow. Last year there were nearly 18,500 births in the Calgary zone. The Government of Alberta estimates that the number of births will continue to increase to nearly 20,000 per year by 2021 and that the number of infants, children and youth aged 19 and under will increase by 20% from 2012 to 2021 (“Alberta Population Projection 2012-2041”). In 2012, there were 356,588 persons aged 19 years and under in the Calgary zone. While we do not have a count of all children cared for by members of the Department of Paediatrics in all facilities and offices across Calgary and southern Alberta, we know that 87,066 children were cared for at the Alberta Children’s Hospital in 2012-13, which represents a 17% increase over the last 4 years. The proportion of admitted children coming from the Calgary zone, other zones in Alberta and outside Alberta was 83%, 14% and 3%, respectively. We teach health professionals at all levels throughout the University of Calgary, as well as the Southern Alberta

Institute for Technology (SAIT) and Mount Royal University. There are 12 Royal College of Physicians and Surgeons of Canada Paediatric Residency Training Programs in Calgary (http://medicine.ucalgary.ca/postgrad). In 2012-13, 93 medical residents and fellows were being trained. Department members initiate or participate in biomedical, clinical, health services and population/public health research. Our main research partner is the ACH Research Institute for Child and Maternal Health (ACHRI, www.ucalgary.ca/research4kids/). The Alberta Children’s Hospital Foundation provides generous support to services in the hospital and to research (www.childrenshospital.ab.ca). James D. Kellner MD, FRCPC Professor and Head

Funding of faculty in the Department of Paediatrics is complex. Fee-for-service funding remains the main source of funding. The Paediatric Academic Alternate Relationship Plan (Academic ARP, AARP) supports about 100 FTEs. There are separate Clinical ARPs for each of Neonatology and the Paediatric Intensive Care Unit. The Sections of Hospital Paediatrics and Medical Genetics each have an Alternate Payment Plan (APP). Several PhD members of the Department are supported by the ACH Research Institute (ACHRI) and several department members have salary awards from external research agencies. In 2013, I completed a five year term as Department Head and, after a rigorous internal and external review, have now been re-appointed for a second term. The first term from 2008 to 2013 was marked by considerable increases in the population served, clinical services and teaching provided and research productivity. During this time, we had a large

growth in both clinical and academic faculty, with 92 new members (37% net increase). This growth occurred during a time of disruptive changes particularly in the health delivery system (dissolution of Calgary Health Region and formation of Alberta Health Services in 2008-09), provincial research institutions (dissolution of Alberta Heritage Foundation for Medical Research and formation of Alberta Innovates-Health Services in 2010) and academic faculty funding systems (elimination of Department-specific AARPs and currently stalled development of a province-wide AARP). There have also been increasing budgetary restrictions with annual reductions in all sources of funding since 2010. Finally, the large growth in the population of children that we serve has put considerable strain on the limited capacity of available hospital and community facilities. Despite these serious challenges, the Department of Paediatrics has continued its growth and development as a clinical and academic department with numerous established and emerging areas of excellence. As described throughout this annual report our dynamic, expert and committed Department members, working with their colleagues and partners throughout Alberta Health Services, the University of Calgary and beyond, continue to make notable achievements and advances that are improving the care of children and their families. It is a privilege to serve in this Department and I am thankful for the opportunity to continue to provide leadership. James D. Kellner MD, FRCPC Professor and Head

Department of Paediatrics | Annual Report 2013

Vision, Mission, Values

The University of Calgary's Department of Paediatrics and AHS, Calgary Zone, provides care at all levels to infants, children and adolescents from Calgary and throughout Alberta, as well as our extended referral areas in British Columbia and Saskatchewan. We are defined by our vision, mission and guiding values. These statements define who we are, how we conduct ourselves, and our purpose as a Department and as individuals.

VISION Excellence in Clinical Service, Advocacy & Leadership, Research & Education (C.A.R.E.)

MISSION To promote, maintain and restore health in children by: • Delivering high quality evidence-based clinical care • Training care givers at all levels • Innovation and Dissemination of new knowledge

VALUES

Annual Report 2013 | Department of Paediatrics

• Compassion • Integrity • Leadership

• Respect • Collaboration • Innovation

Department Organization and Leadership

Dean Faculty of Medicine UNIVERSITY OF CALGARY Department head Paediatrics Dr. Jim Kellner

deputy head clinical & Strategic Affairs Dr. Mike Leaker

deputy head Professional affairs Dr. Val Kirk

Deputy head Education Dr. Ron Anderson

Safety Leader Dr. Sharron Spicer

Department Manager Wes Schreiber

AARP Controller Marco Romanzin

Physician Affairs Coordinator Kellie McKeil Coordinator Physician Remuneration and Contracts Karen Rudd Manager of Administrative Services Alanise Featherstone Neonatology ARP Financial Analyst Vacant Billing Coordinator Tammy Bouchard

Sections, Divisions, Units

• • • • • • • • • • • • • • • • • • • •

Behavioral Research Unit – Dr. Deb Dewey Cardiology – Dr. Frank Dicke Critical Care – Dr. Simon Parsons Community Paediatrics – Dr. Stephen Wainer • Child Abuse – Dr. Neil Cooper Developmental Paediatrics – Dr. JF LeMay • Adolescent – Dr. April Elliot Emergency Medicine – Dr. Angelo Mikrogianakis Endocrinology – Dr. Daniele Pacaud Gastroenterology – Dr. Steve Martin Genetics – Dr. Francois Bernier Hematology – Dr. Michael Leaker Hospital Paediatrics – Dr. Michelle Bailey Infectious Diseases – Dr. Susan Kuhn Neonatology – Co-Chiefs Dr. Albert Akierman and Dr. Anne Tierney Nephrology – Dr. Julian Midgley Neurology – Dr. Jong Rho Oncology/Bone Marrow Transplant – Dr. Doug Strother Palliative Care – Dr. Marli Robertson Respirology – Dr. Mark Anselmo • Sleep Medicine – Dr. Valerie Kirk Rheumatology – Dr. Susanne Benseler Research Methods Team – Dr. Gillian Currie

Department of Paediatrics | Annual Report 2013

Zone Medical Director Calgary ALBERTA HEALTH SERVICES

ume, pgme, cme programs and directors

• Undergraduate Medical Education – Dr. Susan Bannister • Post-Graduate Medical Education • General Paediatrics – Dr. Kathy Tobler • General Paediatrics – Dr. Deb Fruitman • Developmental Paediatrics – Dr. Ben Gibbard • Emergency Medicine – Dr. Izabella Sztukowski • Endocrinology – Dr. Jonathan Dawrant • Gastroenterology – Dr. Leanna McKenzie • Hematology/Bone Marrow Transplant – Dr. MacGregor Steele • Infectious Diseases – Dr. Rupesh Chawla • Medical Genetics – Dr. Mary Ann Thomas • Neonatology/Perinatology – Dr. Majeeda Kamaluddeen • Nephrology – Dr. Lorraine Hamiwka • Neurology – Dr. Michael Esser • Respirology – Dr. Marielena DiBartolo

Site Chiefs

• Paediatrics • FMC – Dr. Chris Lever • PLC – Dr. Kelleigh Klym • RGH – Dr. Darryl Palmer • SHC – Dr. Harish Amin • Neonatology • ACH – Dr. Alixe Howlett • FMC – Dr. Anne Tierney • PLC – Dr. Essa El Awad • RGH – Dr. Deborah Clark • SHC – Dr. Harish Amin

• Continuing Medical Education – Dr. Julian Midgley

Annual Report 2013 | Department of Paediatrics

Description of Department Members

Within the 18 Clinical Sections, 3 Clinical Divisions and 3 Academic Units, there were 285 members as of September 2013. Of these, 242 had primary academic appointments to Paediatrics and 43 had cross-appointments. This slightly reduced number from 2012 reflects a more precise count and the interim status of several new members. Most members are MDs (or equivalent), while 25 members are PhDs. The median age in the Department is 46 years and the range is 29 to 81 years. The female/male ratio in the Department is now approximately 50%/50%. Amongst members less than 50 years old, 65% are female, while amongst members 50 years or older, 35% are female.

Members of the Clinical Section of Genetics are also primary Academic members of the Faculty of Medicine Department of Medical Genetics. Members of the Clinical Section of Oncology are also primary Academic members of the Faculty of Medicine Department of Oncology.

Academic Status

Status

Primary Appointments (242)

Cross Appointments (51)

Clinical Faculty

Adjunct/ Research Faculty

GFT Faculty

Clinical Faculty

Adjunct/ Research Faculty

GFT Faculty

Lecturer

The largest 4 sections, comprising 56% of all members, include:

Assistant Professor

107

• Community Paediatrics (55 members)

Associate Professor

• Emergency Medicine (52 members) • Hospital Pediatrics (30 members)

Full Totals

161

• Neonatology (24 members) The other sections, divisions and units have 3 to 15 members.

Department of Paediatrics | Annual Report 2013

Zone Paediatric Executive Committee 2013

Â&#x2021; Front row, seated: Drs. Susan Kuhn (Infectious Diseases), Sharron Spicer (Safety), Marli Robertson (Palliative Care), Val Kirk (Deputy Head, Professional Affairs), Jim Kellner (Department Head), April Elliott (Adolescent Medicine), Frank Dicke (Cardiology) Middle row: Drs. Bill Hyndman (Surgery, guest), Angelo Mikrogianakis (Emergency), Jong Rho (Neurology), Deb Dewey (Behavioural Research Unit), Deb Fruitman (General Paediatrics PGME Program), Albert Akierman (Neonatology), Abdul Rahman (Child Psychiatry, guest), David Chaulk (Facility Medical Director, guest), Daniele Pacaud (Endocrinology), Gillian Currie (Research Methods Team), Julian Midgely (Nephrology and Continuing Medical Education), Jean-Francois Lemay (Developmental Paediatrics) Back row: Mr. Wes Schreiber (Department Manager), Drs. Stephen Wainer (Community Paediatrics), Simon Parsons (Critical Care), Michelle Bailey (Hospital Paediatrics), Susa Benseler (Rheumatology), Mike Leaker (Deputy Head, Clinical and Strategic Affairs, and Hematology), Steven Martin (Gastroenterology), Mark Anselmo (Respirology), Ron Anderson (Deputy Head, Education), Susan Bannister (Undergraduate Medical Eduction), Doug Strother (Oncology) Missing: Ms. Margaret Fullerton (ACH VP, guest), Drs. Harish Amin (Site Leader, South Health Campus), Francois Bernier (Medical Genetics, Jeremy Luntley (Anaesthesia, guest).

Annual Report 2013 | Department of Paediatrics

Administrative, Support and Research Staff

DEPARTMENT ADMINISTRATIVE OFFICES Wes Schreiber - Department Manager Alanise Featherstone - Office Manager Marco Romanzin - AARP Controller Karen Rudd - Physician Contracts and Remuneration Coordinator Kellie McKeil – Physician Affairs Coordinator Tracey Boyle - Administrative Assistant Karen Croucher - Administrative Assistant (Drs. Kellner and Leaker) Claire Trojan - Administrative Assistant (Drs. Anderson and Kirk) Shahin Hassam – Administrative Assistant Kari Spencer – Administrative Assistant Tammy Bouchard - Billing Coordinator Kelly Craig - Billing Clerk Patricia Royle - Billing Clerk Nick Heazell – Website and Design Admin There are over 75 administrative assistants, other support and research staff who support the department at all Alberta Health Services and University of Calagary sites.

Department of Paediatrics | Annual Report 2013

Overview of Clinical Sections and Divisions, and Research Units

SECTIONS & Divisions Adolescent Medicine Cardiology Community Peadiatrics Critical Care Developmental Peadiatrics Emergency Medicine Endocrinology Gastroenterology Hematology Hospital Pediatrics Infectious Diseases Medical Genetics Neonatology Nephrology Neurology Oncology Palliative Medicine Respiratory Rheumatology

Annual Report 2013 | Department of Paediatrics

RESEARCH UNITS Behavioural Research Unit Research Methods Team Maternal and Child Team: Dr. Suzanne Tough

Section of Adolescent Medicine

Highlights Physician/Faculty Listing: Dr. April Elliott – Division Chief Dr. Jorge Pinzon Dr. Ellie Vyver

In 2012 Community Outreach of Pediatrics and Psychiatry in Education (COPE) expanded to include junior and high school youth, continuing with the same underlying principles that marked the success of the original COPE service: school based identification of youth struggling with medical or emotional issues impacting success at school, comprehensive pediatric or psychiatric consultation, medical treatment, case management by COPE family liaisons, family therapy as appropriate by the COPE therapist, and referral to appropriate resources. Photo courtesy of Bill Longstaff via Flickr’s Creative Commons-licensed content

Ms R. Wadman (CNS) and Dr Pinzon, adolescent medicine specialist, joined the COPE physician team in the 2012-2013 school year to provide services to the referred adolescents. The youth presented with multiple complex issues including learning difficulties, mental health issues, drug use, family system problems, social issues, and behaviour problems. Through COPE 43 youth received physician consultation in a variety of schools in Calgary and area. Due to the complex nature of their issues, many youth needed to be seen on multiple occasions. Youth, families, and school personnel have reported successes as a result of the adolescent COPE initiative, for example, medication management of mental health concerns, improved school attendance, referrals for counselling, and increased motivation to engage with school.

One of the challenges that both families and youth face is that they are not connected to family physicians. This is one of the critical roles that schools play; they are able to connect families to physicians through their partnership with COPE. One role of the family liaisons is to then help the family to access a family physician. COPE is a partnership between Alberta Health Services, school jurisdictions in Calgary and area, and Child and Family Services. COPE is a true example of an interasectoral collaboration that benefits youth and their families across the multiple systems they are in contact with.

Department of Paediatrics | Annual Report 2013

special feature

PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment)

every year over 6000 children present to the alberta Children’s Hospital emergency department because of vomiting or diarrhea (usually referred to as gastroenteritis). Typical treatment involves ensuring the children maintain adequate hydration; however, physicians have little to offer to help symptoms resolve sooner. Times are changing - a team of researchers, led by Dr. Freedman, from the Alberta Children’s Hospital Emergency Department, are conducting a national study (PROGUT – Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) evaluating the use of a novel therapy – probiotics – in children with diarrhea and vomiting. With funding provided by the Canadian Institutes of Health Research, nearly 900 children will be enrolled over the next 3 years in 5 Canadian Paediatric emergency departments to determine if probiotics should be used to help affected children feel better sooner.

Together these landmark studies will clarify the role of probiotics in children with gastroenteritis. These endeavours build on Dr. Freedman’s prior innovations in the field of gastroenteritis which includes the introduction into routine use of a medication which helps expedite the resolution of vomiting and the development of a severity of disease score which is being used as a standardized outcome in gastroenteritis research. Additionally, his research program has expanded to include developing countries such as Pakistan, where he is now evaluating the use of anti-vomiting medications with funding provided by the Bill & Melinda Gates Foundation and the Thrasher Research Fund.

Interest in this work is not limited to Canada; the National Institutes of Health in the United States is funding a similar probiotic study (using a different product), which is being coled by Dr. Freedman and will include 8 Paediatric emergency departments. The latter study is being conducted concurrently and will also include nearly 900 children.

ANNUAL REPORT 2013 | DEPARTMENT OF PAEDIATRICS

special feature

Paediatric Update Conference

The inaugural ACH Paediatric Update Conference took place in the Kinsmen Learning Centre of the Alberta Children's Hospital on the 10th and 11th of May 2013. The main objective of the conference was to gain new knowledge to improve management of patients and optimise referrals to tertiary care. The conference attracted over 100 physicians and health care workers from Alberta, British Columbia and Saskatchewan who had a mix of plenary and breakout sessions on a wide variety of medical and surgical topics relevant to presented by faculty from the Alberta Children's Hospital. The key note speaker was Dr Harriet MacMillan from the Offord Centre for Child Studies at McMaster University who gave a stimulating address on "Responding to Child Maltreatment: Lessons Learned and Where from Here?" The conference ended with a lively and interactive Provocative Panel that debated “Is childhood obesity a social problem or a medical problem?”. A post conference Simulation Course took place with a hands on experience for "Paediatric Acute Care in the Office: The first few minutes". The conference received excellent evaluations from the attendees and a second Paediatric Update Conference is planned for 2014. Further details on the Conference can be seen by visiting this URL: http://medicine.ucalgary.ca/files/med/FINAL_ ACHPaedUpdate_13.pdf

Department of Paediatrics | Annual Report 2013

Section of Cardiology

Highlights Physician/Faculty Listing:

Our latest staff additions include:

Dr. Frank Dicke - Section Chief

Dr. Steven Greenway - Sept 2012 - expertise in heart failure, heart transplant and cardiac genomics

Dr. Robin Clegg

Dr. Erika Vorhies - Sept 2013 - expertise in pulmonary hypertension and cardiac critical care

Dr. Deb Fruitman Dr. Michael Giuffre Dr. Steven Greenway Dr. Joyce Harder Dr. Kim Myers Dr. David Patton Dr. Erika Vorhies

The section of Cardiology continues with its excellence in cardiac imaging including cardiac MRI, CT, and echocardiography performance, teaching, and research, driven by Drs. Patton and Myers. Over the past year we have also instituted a home defibrillator program for at risk arrhythmia patients spearheaded by Dr. Robin Clegg.

Dr. Robin Clegg and Clinic Nurse Patty Knox of the Home Defibrillator Program with their home defibrillator.

Dr. Joyce Harder in association with Dr. Pam Veale have initiated a developmental screening protocol in clinic. Dr. Greenway has initiated a home and ward milrinone protocol to keep patients out of the ICU. Dr. Giuffre has served as AMA president and Dr. Fruitman has been fully active as paediatric program director while continuing her expertise in fetal echocardiography.

Annual Report 2013 | Department of Paediatrics

Drs. Dicke and Myers are also involved with global health and the initiation of projects to help improve paediatric cardiac care in Georgetown Guyana in association with the Libin Cardiovascular Institute.

Section of Community Paediatrics

Highlights The Section of Community Paediatrics (SCP) continues to focus on enhancing the quality of medical care being provided in the community. This is being achieved through programs that improve communication and collaboration with primary care providers, enable easier access to community paediatric consultation services, promote and support shared-care models for complex patients and address the lack of resources that community paediatricians face in office practice. Examples of these initiatives include: Paedlink Telephone Consultation Service: provides family physicians with easy and immediate access to telephone consultations from community paediatricians. This service enhances paediatric care in the community, reduces the need for emergency room visits and specialist referral, and promotes collegiality and communication between community paediatricians and family physicians. Community Paediatric Resource Website (calgarypaeds.org): the myriad and ever-changing landscape of community agencies, websites and other resources is a constant challenge for paediatricians and families and this growing website focuses on providing up to date and relevant information for a very wide range of conditions and services.

Dr. Kristin Evashuk from the Paedlink Telephone Consultation Service.

Primary Care Network (PCN) affiliations: in order to provide a greater range of services a number of clinics have joined PCNs. These novel partnerships have facilitated dietitian, resource navigation and other resources and have greatly improved the ability of community paediatricians to provide comprehensive and quality care.

Department of Paediatrics | Annual Report 2013

Central Consultation Service: will allow “one-stop” access to community paediatrician consultation. This service will ensure that family physicians, in-patient units, emergency rooms and other referring agencies are able to obtain the “first available” paediatrician appointment at a clinic convenient to the parent. It is anticipated that this will substantially reduce the frustration and complexity of connecting a child with a paediatrician, greater parent satisfaction and timelier access to specialist medical care. Neurology Shared-Care Project: a collaboration with the Section of Paediatric Neurology to support community paediatric care of children with seizures and other neurologic concerns. This project aims to ensure greater communication and collaboration between neurologists and community paediatricians. An immediate goal is the development of share-care models for epilepsy management. This year Dr. Starr Cardwell, Dr. Kathleen Mitchell, Dr. Cheri Stanzeleit and Dr. Vicki Kendrick retired from clinical practice. These physicians have provided exemplary service over many years in practice and their commitment, advocacy, expertise and service to Community Paediatrics will be sorely missed. We wish them all the best for the future.

Annual Report 2013 | Department of Paediatrics

Physician/Faculty Listing:

Dr. Natalie Forbes

Dr. Jane Ng

Dr. Frank Friesen

Dr. Peter Nieman

Dr. Cara Gilman

Dr. Steven Olliver

Dr. Roxanne Goldade

Dr. Lane Racher

Dr. Sivalingum Govender

Dr. Swait Rastogi

Dr. Janice Heard

Dr. Swoti Rastogi

Dr. Hardally Hegde

Dr. Lauren Redgate

Dr. Darrell Palmer - RGH Site Chief

Dr. Della Ho

Dr. Lioba Redel

Dr. Jennifer Macpherson Medical Lead, Child Abuse Program

Dr. Keith Jorgenson

Dr. Novak Michele

Dr. Michele Kalny

Dr. Daniel Ross

Dr. Cham-Pion Kao

Dr. Heidemarie Schroter

Dr. Susan Aitken

Dr. Lori Kardal

Dr. Elizabeth Shyleyko

Dr. Hilda Angeles

Dr. Suba Karthikeyan

Dr. Cheri Stanzeleit

Dr. Rachel Bond

Dr. Brian Kelly

Dr. Pamela Stone

Dr. Starr Cardwell

Dr. Victoria Kendrick

Dr. Tracy Taylor

Dr. Nathaniel Chan

Dr. Alexander Leung

Dr. Byron Wong

Dr. Neil Cooper

Dr. Linda Loovere

Dr. Monique Wright

Dr. Kate Culman

Dr. Roderick Mackenzie

Dr. John Wu

Dr. Alfred Dei-Baning

Dr. Kathleen Mitchell

Dr. Douglas Yeung

Dr. Amanda Evans

Dr. Danielle Nelson

Dr. Desiree Yow

Dr. Stephen Wainer - Section Chief Dr. Kelleigh Klym - PLC Site Chief Dr. Christopher Lever - FMC Site Chief

Dr. Kristin Evashuk

Section of Critical Care

Highlights Physician/Faculty Listing: Dr. Simon Parsons – Section Chief Dr. Kathleen Tobler – General Paediatric PGME Program Director Dr. Jaime Blackwood Dr. Shauna Burkholder Dr. Robin Cox Dr. Tanya Drews Dr. Jonathan Gamble Dr. Elyahu Gilad Dr. Elaine Gilfoyle Dr. Jeremy Luntley Dr. Meagan Mahoney Dr. Barbara Catherine Ross Dr. Terry Stewart

The Paediatric Intensive Care Extra Corporeal Life Support (ECLS) Program What is ECLS? ECLS is a temporary lung and/or heart support system which can be used on newborns, children and adults. This treatment is used in our Paediatric Intensive Care Unit for children with acute life-threatening reversible respiratory or cardiac failure who are not responding to maximal ventilator, medical and surgical treatment. Our new ECLS program provides these infants and children another chance at survival. Why we are unique?

Starting the Program Our extensive training process included the General Surgeons, Cardiologists, OR nurses, Paediatric Intensivists, Nurses and Respiratory Therapists. In addition we needed to train a perfusionist and an ECLS specialist. Thanks to support from the Alberta Children’s Hospital Foundation, we were also able to secure the specialized equipment needed for the ECLS program. How many children have needed ECLS? he ECLS team has been activated for potential initiation T of therapy a total of 39 times to date. In 18 of these cases, ECLS has been initiated with an overall survival rate of 83%

Unlike other paediatric hospitals with ECLS programs, the Alberta Children’s hospital does not have a Paediatric Cardiac Surgery program. There are no cardiac surgeons or perfusionists located in our hospital to provide support in the initiation of ECLS therapy and/or care after therapy is started. In addition, we currently do not have 24 hour access to in-house general surgeons to respond to emergency issues related to ECLS therapy.

• 14 of these children are currently healthy and back in their homes

How did this impact our new program?

• The survival rate for children to be discharged home who have received ECLS is between 41% and 57% according to ELSO.

In order to launch this important new treatment program

for our critically ill population, we had to train all our team members for a brand new program.

How are we doing compared with other centers? • The Extra Corporeal Life Support Organization (ELSO) has a database that tracks children put on ECLS internationally.

Department of Paediatrics | Annual Report 2013

Logan Borthwick was the first ECLS cannulation patient. Logan is now happy and healty.

• ACH has a current survival rate for children to be discharged home of 83% with full neurological recovery in all by one. • It is certainly our belief that all fifteen survivors would have died without ECLS. • In some cases (4) the heart had actually stopped beating effectively or completely – half of children in this group survived. • Most children we have treated with ECLS at the Alberta Children’s Hospital had serious infections including septic shock. • Most ECLS centers do not treat septic shock with ECLS, believing it will not be successful. • Death from infection remains one of the most significant challenges of Intensive Care Medicine today but our ACH PICU mortality rate for severe infections (non-neurological) is now approaching zero. We Are Very Proud of • The efforts of our community that helped to fund this program. • Our hard work to implement the program. • A success rate that is second to none. • A reduction in our overall PICU mortality by 20-30% • We are saving the lives of an additional 6-10 children per year. Annual Report 2013 | Department of Paediatrics

Section of Developmental Paediatrics

Physician/Faculty Listing: Dr. Dr. Jean-François Lemay – Section Chief Dr. Ben Gibbard – PGME Program Director Dr. Jennifer Fisher Dr. John McLennan Dr. Alison Moore Dr. Ted Prince Dr. Heidi Schroter Dr. Pamela Veale

Highlights

Innovative Project Highlights

The Developmental Paediatric Section is a group of developmental pediatricians, child psychiatrists and child neurologist. We are a service of excellence for Neurodevelopmental Disorders. Our section members offer expertise in Autism, ADHD, developmental disabilities, paediatric rehabilitation, child psychiatry and abuse, and paediatric neurology.

Following two major donations made to Alberta Children’s Hospital Foundation, 2 members of our section are significantly involved in the following:

The section of Developmental Paediatrics and the ACH/Child Development Service, located at the Child Development Centre, is working closely in an ongoing significant service model with changes to meet the growing demand, change in demographics and complexity of the paediatric population we serve.

1. Expanding assessment services to develop meaningful, motivating goals with families and the rehabilitative team.

Two key areas under development include:

2. Creating additional programming that fosters independence and meaningful participation by disabled children and youth.

• Emphasis on the early recognition of social risk factors associated with complex neurobehavioral disorders that contribute to secondary and tertiary prevention initiatives.

3. Fostering a support network for disabled children and youth, and their families.

• Development of an effective testing modality for Autism Spectrum Disorder which would support Level I screening in partnership with community providers and referral of the more ‘difficult to diagnose’ children to our tertiary service.

• Dr. Ted Prince is the Interim Medical Lead for Rehabilitation in the Vi Riddell Pain and Rehabilitation Center (work in collaboration with the ACH Foundation and AHS). The goals of this rehabilitation program include:

4. Expanding opportunities for care providers to develop advanced skills related to pediatric rehabilitation. • Dr. Jean-François Lemay was the Chair of the Brain Health, Neurodevelopmental Disorders Working Group who worked on the vision and roadmap of the future

Department of Paediatrics | Annual Report 2013

Dr. Jean-Francois Lemay at the Child Development Centre

Alberta Children’s Hospital Centre of Excellence in Neurodevelopmental Disorders (work in collaboration with the ACH Foundation and AHS). Clinical Services Provided • Ambulatory Clinics and Services offered at the ACH/ Child Development Services include: a. Developmental Paediatric Clinics b. Developmental Psychiatry Clinics c. Consultative Clinics (Phone) for Community Pediatricians d. Developmental Neurology Clinics e. Child Development Medication Assessment Services f. Fetal Alcohol Spectrum Disorder Clinics • Our section does not offer 24/7 Inpatient or Admitting Services. However, we are offering on-call and emergency outpatient consultation services if required and consultation to Child Abuse Services is provided when needed.

Annual Report 2013 | Department of Paediatrics

Section of emergency medicine

HIGHLIGHTS – CLINICAL CARE, EDUCATION AND RESEARCH

85% of all paediatric eD visits in calgary are seen at the alberta children’s hospital

Delivering high quality evidence-based clinical care • Annual census of 72,000 ED visits (increase of 10% over previous year) • 85% of all paediatric ED visits in Calgary are seen at ACH • Highest percent of ED patients discharged within 4 hours (Calgary Zone target time interval) • Continuous innovation in patient care strategies for efficient clinical flow • january 2013 began 12 hr/day PEM coverage at the South Health Campus • Leaders in regional/provincial/national clinical care pathway development • Asthma, Gastroenteritis, Appendicitis, Status Epilepticus, Sepsis • New initiatives in quality improvement and patient safety

•

• • •

Training caregivers at all levels • Paediatric Emergency Medicine Training Program (2012/13): • PEM Residency: 7 PEM subspecialty trainees • 186 Mandatory rotations for residents from other programs

•

• 67 Clinical Clerks UofC • 54 Visiting Learners • 81 first year Family Medicine Residents at the SHC • 4 Nurse Practitioner trainees PEACH - Hosted 2nd Paediatric Emergency Medicine CME Conference • 120 community physicians and nurses attended from across Alberta, western Canada and internationally PALS (Paediatric Advanced Life Support) Training and certification courses Paediatric Resident Quality Improvement Curriculum Paediatric Simulation • Interprofessional team training with allied health professionals (RN and RRT) and all levels of medical trainees (UME, PGME, Fellowship, Attending Physicians) • Simulation leaders at ACH, U of C, provincially, nationally and internationally • Mobile (Outreach) Simulation educating around acute care paediatrics to community partners in their local settings across Southern Alberta and Southeastern British Columbia 20-24 rural and regional centres per year

• Over 500 health care professionals per year

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

Highest percent of ED patients discharged within

4 hours

(Calgary Zone target time interval)

Innovation, Research and Dissemination of new knowledge ACH clinician scientists and educators are national and international leaders at: 1. Generating best evidence for the care of severely ill and injured children, • PROGUT: Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment study • Concussion 2. Determining the best ways to teach health care professionals to incorporate new knowledge into their practice, • National Centre of Excellence - Knowledge Mobilization: TRanslating Emergency Knowledge for Kids (TREKK) 3. Developing collaborative educational and research programs using Simulation: • Providing clinicians the skills and confidence to care for sick children • Assessing and improving the quality of CardioPulmonary Resuscitation (CPR) • Examining Paediatric Resuscitation Education using Simulation and Scripted Debriefing (EXPRESS) • International Network for Simulation-based Innovation, Research and Education (INSPIRE network) • Trauma Resuscitation in Kids (TRIK) national trauma course 4. Developing clinical indicators for determining if severely ill and injured children receive optimal care. • The Development of Quality Indicators for High Acuity Paediatric Conditions Requiring Emergency Care.

Annual Report 2013 | Department of Paediatrics

Physician/Faculty Listing:

Dr. Seen Chung

Dr. Gordon Mcneil

Dr. Shawn Dowling

Dr. Andre Michalchuk

Dr. Jenn D’Mello

Dr. Sarah McPherson

Dr. Marc Francis

Dr. Patrick Milhalicz

Dr. Stephen Freedman

Dr. Cheri Nijssen-Jordan

Dr. Roger Galbraith

Dr. Lisa Odendal

Dr. Jennifer Graham

Dr. Adam Oster

Dr. Jeffrey Grant

Dr. Naminder Sandhu

Dr. Vince Grant

Dr. Katharine Smart

Dr. Jonathan Guilfoyle

Dr. Derrick Smith

Dr. Carey Johnson

Dr. Antonia Stang

Dr. David Johnson

Dr. Izabela Sztukowski

Dr. Francois Belanger

Dr. Kevin Johnson

Dr. Margaret Thomson

Dr. Donald Bethune

Dr. Kristen Johnson

Dr. Jennifer Thull-Freedman

Dr. Michele Bjornson

Dr. Christine Kennedy

Dr. Hussein Unwala

Dr. Andrea Boone

Dr. Tanuja Kodeeswaran

Dr. Philip Ukrainetz

Dr. Mark Bromley

Dr. Verna Krisik

Dr. Ping Wei Chen

Dr. Gavin Burgess

Dr. Russell Lam

Dr. Ian Wishart

Dr. David Chaulk

Dr. Kerri Landry

Dr. Bryan Young

Dr. Adam Cheng

Dr. Lorraine Mabon

Dr. Angelo Mikrogianakis – Section Chief Dr. Kelly Millar – PGME Program Director Dr. Graham Thompson – Acting PGME Program Director Dr. Ed Les – ACH Clinical Lead (to Sept 2012) Dr. Mary-Louise O’Byrne – ACH Clinical Lead (from Sept 2012)

special feature

Paediatric Emergency Medicine at the South Health Campus

On January 13, 2013 the pediatric emergency physicians of the Alberta Children’s Hospital (ACH) embarked on a new initiative to better serve the children and families of Calgary and the surrounding area. Pediatric Emergency Medicine physicians would provide twelve hours of pediatric coverage per day at the new South Health Campus Emergency Department. This model of a satellite Pediatric Emergency Department was a first in Calgary, as well as in all of Canada. It made sense for the following reasons: • The Alberta Children’s Hospital was very busy seeing over 200 patients per day, for a total of 72,000 visits per year; • Many young families live in the southeast; • Calgary’s growth would justify two sites for families to receive high level pediatric emergency care.

Dr. Cheri Nijssen-Jordan in action with a family at the SHC Paediatric Emergency Department

The South Health Campus Emergency Department provides options and convenience for families and their children. Approximately 1,200 pediatric patients are cared for at the South Health Campus Emergency Department each month. Both the South Health Campus Emergency Department and the Alberta Children’s Hospital Pediatric Emergency Medicine physicians should be commended for this new partnership that benefits the children and families of Calgary by ensuring highlevel pediatric care across the city.

Department of Paediatrics | Annual Report 2013

Section of Endocrinology

Highlights Physician/Faculty Listing: Dr. Danièle Pacaud - Section Chief Dr. Jonathan Dawrant - PGME Program Director Dr. Paola Luca Dr. Josephine Ho Dr. Carol Huang Dr. Rebecca Perry Dr. David Stephure

For the Section of Paediatric Endocrinology, this past year has been mark by the launch of two new programs: 1) Implementation of the Provincial Insulin Pump Therapy Program at the ACH diabetes clinic and 2) the Paediatric centre for Weight and Health: Calgary Site. Implementation of the Provincial Insulin Pump Therapy Program at the ACH Diabetes clinic: Management of type 1 diabetes involves subcutaneous delivery of insulin either through multiple daily injections or through a continuous insulin infusion pump. Use of a pump requires special knowledge and significant extra costs to the families choosing this mode of treatment. However, it is the most physiologic way to deliver insulin providing better diabetes control and more flexibility with daily routines. In June of 2013, the Provincial Insulin Pump Program was launched. Our clinic has been a key player in setting up the eligibility criteria and standard of care for the paediatric part of this program. Further, our clinic has continued to provide education and support for those already using this therapy and for those wishing to start using it. Currently in our clinic, ~60 children are switch to this therapy each year and about 20% of children affected by type 1 diabetes are managed with an insulin pump.

Visit the webpage to keep up to date on services and hours: http://ow.ly/rcIjY The new Provincial Program has significantly lessened the financial burden of this form of therapy for individuals with type 1 diabetes as illustrated by this mother’s testimony: “The insulin pump significantly improved our quality of life by giving back to us some sense of normalcy and it also gave us the ability to achieve significantly better glycemic control. We paid out-of-pocket for 10 years to continue using it. We calculated that by the time the insulin pump program came into effect, that we had sacrificed close to $85,000 on three insulin pumps and all the monthly supplies.Having the Alberta Pump Program provide coverage for insulin pumps and supplies was a very positive turning point in our lives. We could now use this amazing medical device that had been responsible for increasing our quality of life and achieving excellent glycemic control without having to make huge financial sacrifices in return.” The Paediatric Centre for Weight and Health: Calgary Site Childhood obesity is major health concern since it is increasing in prevalence and has significant associated comorbidities which can have a large impact on quality of life and future health. The goal of the Alberta Health Services pediatric provincial weight management initiative was

Department of Paediatrics | Annual Report 2013

to develop a coordinated and comprehensive approach to preventing and managing childhood obesity and an expansion of services for children and families in order to reduce the burden of disease in Alberta. As a part of this, a specialty care clinic for pediatric obesity was started at the Alberta Children’s Hospital (ACH) and has been operating fully for approximately one year.

From Left to right: Dr. Rebecca Perry, Dr. Paola Luca, Dr. Jonathan Dawrant, Dr. Danièle Pacaud, Dr. Josephine Ho, Dr. Carol Huang

The ACH specialty clinic is comprised of paediatric endocrinologists, pediatricians, registered dietitians, nurses, exercise physiologist, social worker and psychologist. The goal of this clinic is to help overweight and obese children and their families by focusing on achieving healthy lifestyle changes. The first clinicians at PCWH started in May 2012 with a few patients seen and the clinic was officially launched in October 2012. Currently, there are approximately 138 active patients in the clinic and we will be expanding services to include the South Health Campus with clinics starting November 27, 2013. In addition, we hope to continue expanding services to include group teaching sessions such as healthy cooking classes in the near future. Visit the webpage to keep up to date on services and hours: http://ow.ly/rcGt6

Annual Report 2013 | Department of Paediatrics

Section of Gastroenterology

Highlights Physician/Faculty Listing: Dr. Steven Martin – Section Chief Dr. Dana Boctor Dr. J. Decker Butzner Dr. Jennifer deBruyn Dr. Helen Machida Dr. Leanna McKenzie – Program Director Dr. Brent Scott Dr. Chris Waterhouse Dr. Iwona Wrobel Dr. Alfred Yeung

Alberta Children’s Hospital re-establishes a state-of-theart gastrointestinal motility laboratory. The recruitment of Dr Alfred Yeung to the section of Gastroenterology, Hepatology and Nutrition has re-established Alberta Children’s Hospital as a national leader in the evaluation and management of children with gastrointestinal motility disorders. With the generous support of the Alberta Children’s Hospital Foundation, the purchase of technologically advanced manometry and pH/MII equipment now enables us to provide specialty GI motility services including high resolution esophageal and ano-rectal manometry, waterperfused small intestinal and colonic manometry, and comprehensive motility testing for children. Dr Yeung completed a sub-specialty fellowship in Paediatric Gastrointestinal Motility at Nationwide Children’s Hospital in Columbus Ohio and together with his team has been working hard since his arrival in August of 2012 to establish the operating procedures for the Motility Laboratory. With the recent approval to begin operations, ACH will evolve into the paediatric GI motility referral centre for Western Canada as this expertise is currently available in only two centres in Canada and in only a dozen centres across the United States.

Pictured are Dr. Alfred Yeung, along with Kristine Thannhauser and Doreen Reid.

Department of Paediatrics | Annual Report 2013

Section of Hematology

Highlights Physician/Faculty Listing: Dr. Doan Le Dr. Michael Leaker - Section Chief, Deputy Department Head Dr. MacGregor Steele – Hermatology and Oncology PGME Program Director Dr. Nicola Wright

The Section of Hematology provides care for children with a wide variety of diseases of the blood and bone marrow, bleeding and thrombotic disorders and immune deficiency syndromes, both congenital and acquired. A new initiative for the Section over the past year has been the establishment of a formal, multidisciplinary clinic for children with hemoglobinopathies such as sickle cell disease and various thalassemia syndromes. Migration into our referral area over the past several years has resulted in a rapid expansion of this population from approximately 20 in 2009 to more than 80 in 2013.

Establishment of the formal multidisciplinary hemoglobinopathies clinic

Migration into our referral area has resulted in a rapid expansion of this population from approximately

in 2009

Annual Report 2013 | Department of Paediatrics

80+ in 2013

These patients learn to manage a lifelong condition and many will develop multisystem involvement during their years in the pediatric clinic. By focusing on providing multiple services in a single visit, we hope to optimize the care for these patients and decrease the number of visits their families must make. At present, as part of each clinic visit, we are able to offer assessment and treatment by: • Specialized primary nursing • Advanced practice nursing • Dietician • Neuropsychology • Specialized diagnostic services (eg, transcranial Doppler, pulmonary function testing) • Social work • Hematologist • Respirology In an ongoing effort to reduce the burden of care for these families, we are working to add additional services such as a dedicated pain management physician to our team. We also hope to increase the resources available to our patients through the creation of a patient and family support group. This clinic is an example of how social factors such as migration can, in a very short timeframe, move a group of disorders from relatively rare to a major focus for our Section.

Section of Hospital Paediatrics

Highlights Simulation Education Programs: The Human Patient Simulation (HPS) Program Paediatricians in the Section of Hospital Paediatrics (SHP) at the Alberta Children’s Hospital have a unique responsibility to provide acute and complex care to 85% of the medical in-patients as well as provide leadership to the ACH “Code Blue” team (responding to a patient experiencing a respiratory or cardiac arrest) on a 24/7 basis. In response to the need to maintain, practice and acquire new knowledge and skills needed to provide these front-line medical in-patient services, a professional development initiative called the Human Patient Simulation (HPS) program was created and launched in 2005. HPS sessions are 3.5 hours in duration and sessions are conducted twice per month. Each hospital pediatrician participates in 2 half-day sessions per year. Sessions are multi-disciplinary in nature and include hospital paediatricians, unit nurses, respiratory therapists and the STEP team. Each session consists of an orientation followed by three in-patient case scenarios with dedicated time for debriefing. The HPS curriculum for any given year is based on an annual “needs assessment”

conducted by collecting feedback from all participating multi-disciplinary groups and consultation with clinical leaders in the Section. Scenarios are designed to simulate the types of patients (both acute and complex) and common urgent/emergent situations (i;e: respiratory distress or arrest, sepsis, anaphylaxis, seizure, etc) that may be typically experienced on the in-patient units. Specific curricular emphasis is placed on code team roles, quality improvement initiatives, patient safety issues, technical skills, introduction and practice of “institution specific” clinical care guidelines and protocols, orientation to new medical equipment, response to communication challenges (including disclosure of adverse events) and inter-disciplinary team building. The HPS program was created and is directed by Dr. Suzette Cooke. HPS session leaders, Drs. Sarah Hall, Lindsay Long and Suzette Cooke are all certified simulation instructors. Nursing educators from Units 2, 3 and 4 co-lead these sessions and support debriefing of the nursing staff. The HPS program at ACH is the only known multidisciplinary staff pediatric simulation continuing professional development program in North America. The HPS program is one of the many unique and innovative programs found under the ACH KidSim umbrella!

Department of Paediatrics | Annual Report 2013

Group shot of several members of the Section of Hospital Paediatrics

Here are some examples of what our participants have to say about HPS:

Physician/Faculty Listing: Full AARP Positions

Dr. Sarah Hall (Section Resident Lead/ Staff Education)

Dr. Michelle Bailey (Section Chief)

Dr. Aaliya Sabir (Quality Improvement)

Dr. Suzette Cooke (Section HPS Lead, U of C Faculty Education)

Dr. Hani Hadi (IT and Informatics/ Scheduling)

Dr. Gemma Vomiero (Deputy Section Chief)

Dr. Jenn Brenner (International Health)

“Excellent hands-on experience! This helps me maintain my readiness for the real thing.” M.D

Dr. Susan Bannister (Clerkship Lead for Paediatrics)

Clinical/Education Positions

The “Just in Time” (JIT) Program

Dr. Preet Sandhu (Section Clerkship Lead/ Educational Research)

“Real – life scenario’s practiced in a safe learning environment” RN “I love that these sessions are multi-disciplinary – this helps make it real!” R.T/ STEP Team “The scenarios were very representative of what we see on our unit. Practicing both the medicine and the teamwork and communication was awesome! Learned a lot in the debriefing too!” - RN

Just In Time (JIT) training is a high fidelity simulation program designed to efficiently teach and evaluate acute care skills and teamwork. The Section of Hospital Paediatrics initiated the JIT program in 2012 with support from the KidSim program. JIT sessions are designed and led by the CTU teaching fellow with mentorship from a hospital pediatrician. Sessions are especially brief and dynamic consisting of a 5 minute orientation, 10 minute

Annual Report 2013 | Department of Paediatrics

Dr. Chantelle Barnard (Family Centered Care/ Clinical Lead/Research)

Dr. Lisa Lemieux Dr. Catherine Macneil Dr. Cristina Stoian Dr. Sidd Thakore (Followup Clinic Lead) Dr. Mike Vila Dr. Chris Andrews Dr. Michelle Jackman Dr. Lori Walker Dr. Theresa Wu Dr. Mary Fras (locum)

Dr. Lindsay Long (JIT lead)

Part Time

Dr. Gary Chow

Dr. Melissa Gross

Dr. Laura Davies

Dr. Kevin Levere

Dr. Dominique Eustace Dr. Barbara Grueger

Partial AARP Positions

Dr. Renee Jackson

Dr. Julie Fisher (Complex Care Lead)

Dr. Quyen Lam

Dr. Lindsay Long – Intubating a simulation subject. The team from the JIT (Just in Time) program

Group shot of several members of the Section of Hospital Paediatrics

scenario and 15 minute debriefing period. JIT scenarios are based on current in-patients who are at highest risk for deterioration. The patient’s very own inter-disciplinary healthcare team (including the senior resident, junior residents, medical students and the patient’s nurse) form the participants for the session. JIT gives the multi-disciplinary team the opportunity to simulate the anticipated pattern of deterioration (i.e.: respiratory distress, decreased LOC, hypovolemic shock, septic shock, seizure, etc) of a high-risk current in-patient. The team is therefore able to rehearse targeted assessment and specific management strategies for the real in-patient thus bringing simulation education to the point of care!

Here are some examples of what JIT participants say about the sessions …

“Our learning was so relevant because the scenario was based on one of our real patients.” CTU Resident “It is helpful to practice as a multidisciplinary team because this is how we perform in real life. I also like that the sessions are very brief – this makes it possible to integrate this valuable learning into our regular work day.” RN

Department of Paediatrics | Annual Report 2013

special feature

KidSIM™ Pediatric Simulation Program at Alberta Children’s Hospital

The KidSIM Pediatric Simulation Program has been training health care professionals both as individuals and as part of interprofessional teams since October of 2005. Since that time, the KidSIM Program has grown significantly and is responsible for the training of approximately 3,500 learners per year. These learners come from all levels of training, from undergraduate learners all the way through to practicing health professionals. They come from diverse backgrounds, everything from rural EMS providers to operating room nurses to attending pediatric intensivists, among many others. The KidSIM program works to provide learners surrogate clinical experience with pediatric patients in as close to a ‘real-life’ situation as possible through the use of high-fidelity mannequins as well as teaching space that mimics the clinical setting as closely as possible. In doing so, it is hoped that the learners experience the pressure and stressors of the real situation, as they work as individuals and in teams, in order to learn more about the assessment and management of these cases. This realism is further enhanced by moulage of the patients, providing the real results of tests and adding personnel to the case to act in various roles (parent, consultant, etc). Evaluation of the scenarios and of the program as a whole are overwhelmingly positive, with a common theme being the request for more and more sessions. In the first 6 years of the program, there has been incredible growth in the number and diversity of learners, as well as growth in the number of areas incorporating simulation into their overall education plan.

Annual Report 2013 | Department of Paediatrics

The mission of the KidSIM Program is to support interprofessional education by working together with physicians, nurses and allied health care providers to ensure optimal accessibility, innovation, leadership and excellence in pediatric experiential learning and simulation education. Simulation is an essential component to meet current and future demands related to healthcare education, experiential learning, team crisis resource management, patient safety, workforce utilization, and clinical research. Since 2005, the program has grown from one mannequin, one basement laboratory at the former ACH site, and a handful of trained educators to one of the broadest and busiest pediatric simulation programs in the world. Through on-going support from the Department of Pediatrics and the ACHF, the program now boasts greater than 80 trained simulation education facilitators, 10 high-fidelity mannequins spanning infancy to adolescence, two simulation laboratories in the new ACH, and very soon a 3,600 square foot simulation centre on the 4th floor of the new ACH. The KidSIM Program has been involved in the delivery of high quality interprofessional pediatric simulation education to over 3,500 learners per year, from undergraduate learners to practicing health care professionals, both at the Alberta Children’s Hospital site, as well as via mobile education to providers in the broader Calgary community, and regional and rural healthcare providers in Southern Alberta and Southeastern British Columbia.

Section of infectious Diseases

HIGHLIGHTS PHySICIaN/FaCulTy lISTINg: Dr. Susan Kuhn* - Section Chief Dr. Rupesh Chawla* - PGME Program Director Dr. Taj Jadavji Dr. James Kellner - Department Head Dr. Mireille LeMay Dr. Otto Vanderkooi

The highlight of the past year for the Section of ID is the expansion and increased profile of our research and clinical activities related to vaccine preventable diseases. The Alberta Children’s Hospital Infectious Diseases, Epidemiology and Vaccine Evaluation Research Team (ACHIEVE; http://www.ucalgary.ca/achieve/), has added a multicentre clinical trial of pertussis vaccine in pregnant women, a Canadian study of HPV vaccine efficacy in young women, in addition to its ongoing projects in pneumococcus (CASPER), influenza (PCIRN), meningococcus, and the work of section members studying hospitalized patients with various vaccinepreventable diseases through IMPACT .

Dr. Joseph Vayalumkal

As a result, ACHIEVE is increasingly recognized as an important contributor to knowledge in vaccine preventable diseases both nationally and internationally. The research team is also steadily building partnerships with colleagues in specialties such as emergency medicine, gastroenterology, and rheumatology in order to address common concerns in vaccine-preventable diseases.

was recruited specifically for its strength in centralized tertiary care of children with tropical diseases as a result of immigration and travel. Currently there is only one other GeoSentinel site in the global network with a pediatric specialist as director. One of the most notable related clinical highlights was something that didn’t make the news: the successful prevention of a measles outbreak through the quick recognition of an imported case, rapid organization and implementation of screening of over 500 exposed persons (patients, staff, healthcare workers, and others), and appropriate intervention strategies for those determined susceptible. The latter highlight illustrates how the biggest success stories are the ones no one knows about!

A new component of the research portfolio in 2012 was the addition of imported infectious diseases, when Calgary became the newest site of GeoSentinel Global Surveillance Network (www.istm.org/geosentinel/main.html). As the sixth site in Canada (one of 57 around the world), Calgary

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

The faculty of Infectious Diseases left to right: Dr. Rupesh Chawla, Dr. Mireille LeMay, Dr. Jim Kellner, Dr. Taj Jadavji, Dr. Joseph Vayalumkal, Dr. Susan Kuhn, Dr. Otto Vanderkooi

Section of Medical Genetics Department of Paediatrics, Faculty of Medicine, Department of Genetics

Section of Medical Genetics ca. 1992 and now December 2013.

Highlights Physician/Faculty Listing: Dr. Francois Bernier – Section Chief Department of Paediatrics, Faculty of Medicine, Department of Genetics Dr. Mary Ann Thomas – PGME Program Director Dr. Aneal Khan – Medical Director, Metabolic Clinic Dr. Robin Casey Dr. Patrick Ferreira Dr. Michael Innes Dr. Julie Lauzon Dr. Brian Lowry Dr. Ross Mcleod Dr. Renee Perrier Dr. Rebecca Sparkes

35 years of genetics at ACH, and over 55,000 families seen. The Genetics Clinic was started in 1977 by Dr. R. B. Lowry as an integral part of the Alberta Hereditary Diseases Program (AHDP). The staff consisted of himself, a nurse and a medical secretary. The clinic was originally housed in the Kinsmen Research Building at the old Alberta Children’s Hospital site. In an era where genetic testing consisted of a mere karyotype and molecular analysis had yet to be developed, patient charts were tracked using rolodex cards. These cards are now archived although still require occasional consultation as subsequent generations seek our services. The rapid rate of gene discovery and the development of new genomic technologies are being accompanied by an increasing number of referrals. Our clinic now has a comprehensive scope of genetics services from prenatal genetics, pediatric genetics and metabolic genetics to adult clinics including neurogenetic, oncogenetic and cardiogenetic patients. A key component of the original AHDP was the outreach service, which has provided uninterrupted clinics to Lethbridge, Medicine Hat and Red Deer for over 30 years. Our clinics are now staffed by over 60 individuals including physicians, genetic counsellors, nurses, dieticians, psychologists and administrative support personnel. In 2013 we saw our 59, 000th family from Southern Alberta!

Annual Report 2013 | Department of Paediatrics

Dr. Brian Lowry ca. 1980 and now December 2013.

We are now on the brink of a revolutionary change in genetics as whole genome sequencing begins to be implemented into clinic care, ushering in the era of genomic medicine. None of us can predict what the next 35 years will bring.

Section of Neonatology

Highlights Select Clinical Services stats • Mean length of stay (LOS) for NICU’s = 10.7. • Total admission to Calgary NICU’s = 3157. • Responsible for 34 Level III beds at the Alberta Children’s Hospital (ACH) and Foothills Medical Center (FMC), and 89 Level II beds at the FMC, Peter Lougheed Center (PLC), South Health Campus (SHC), and Rockyview General Hospital (RGH). • Total transports and transfers within the Southern Alberta Network = 708. Clinical Care • Construction for the new 14 bed Edwards Family NICU continues to progress. You can see the full update on this in the feature on page XX. • The functional program for the PLC Women’s Health Redevelopment Project which includes a new Family Centered 30 room Level II NICU with a capacity for 36 babies was completed; our thanks to Maciej Burzynski, Senior Project Manager, Alberta Infrastructure, Capital Projects, Health Facilities Branch.

• Dr. Deborah Clark, Chair, Neonatal Coordinating Committee: this committee has expanded its membership in the last year to ensure a more multidisciplinary review of all items brought forward for discussion. Membership now includes: 7 neonatologists each of whom chairs a Clinical Working Group; 1 neonatologist who chairs the Quality Improvement Committee; 1 Quality Improvement nurse; 1 webmaster (RN); 1 clinical nurse manager; 1 clinical nurse educator; 2 Neonatal Nurse Practitioners (both are representatives on Provincial Working Groups); One NNP is responsible for monitoring/guiding the development of suitable parent handouts where required; 1 Registered Respiratory Therapist  Clinical Working Groups: The number of these has also expanded and the chair of each provides a report of current activities to the Coordinating Committee. Original Clinical Working Groups struck were for CNS, CVS, Respiratory, Surgery and GI issues. This year, we have added an Infection Prevention Group, a Palliative Care Group, a Discharge Planning/Parent Education Group and an Oral Feeding Group  Clinical Practice Guidelines Reviewed and Approved = 13.  Educational Handouts Reviewed and Approved = 5

Department of Paediatrics | Annual Report 2013

Group photograph of several members of the Section of Neonatology

Quality Improvement: The Neonatal Quality Improvement Committee (NQIC) meets monthly, co-chaired by Stacey Dalgleish BN NNP and Wendy Yee MD. Quality improvement initiatives have continued in the areas of infection prevention, respiratory management of VLBW infants, supporting breast milk/human milk feeding in NICU infants, supporting skin-to-skin care for NICU infants, developmentally appropriate feeding advancement, age-appropriate developmental care of NICU infants and discharge planning. A multidisciplinary delegation of providers from the regional NICUs attended a Quality Improvement Conference (Evidence-based Practice for Improving Quality – EPIQ Conference) in Toronto, Ontario in February 2013, with funding support from the Section of Neonatology. The group presented several invited talks.

Physician/Faculty Listing: Dr. Ayman Abou Mehrem Dr. Albert Akierman – Interim Section Chief Dr. Essa Al Awad – PLC NICU Site Leader/ Under-Grad. Education Dr. Belal Alshaikh – Locum Neonatologist Dr. Harish Amin – SHC NICU Site Leader and Paediatric Medical Site Lead Dr. Jill Boulton – Quality Assurance Lead Dr. Deborah Clark – RGH NICU Site Leader Dr. Carlos Fajardo - Data Coordinator Dr. Andrei Harabor – Functional Echo Lead

Annual Report 2013 | Department of Paediatrics

Dr. Shabih Hasan Dr. Leonora Hendson Dr. Alixe Howlett – ACH NICU Site Leader Dr. Majeeda Kamaluddeen – Program Director, Neonatal Perinatal Medicine Dr. Abhay Lodha – Chairman, Continuing Medical Education Dr. Jack Rabi – Chair, Finance Committee/SCM Dr. Nadira Rashid – Locum Neonatologist

Coordinator, Post -Graduate Education (Paediatric Residents) Dr. Amelie Stritzke Dr. Sumesh Thomas – Medical Director, Neonatal Transport Team Dr. Anne Tierney – FMC NICU Site Leader/ Interim Deputy Chief Dr. Wendy Yee – Quality Assurance Coordinator Dr. Kamran Yusuf – Director, Neonatal Research

Dr. Reg Sauve – Director, Neonatal Follow Up Clinic Dr. Nalini Singhal Dr. Amuchou Soraisham –

special feature

ACH Neonatal Intensive Care Unit (NICU) update November 2013

Construction for the new 14 bed Edwards Family NICU continues to progress. After a design process which involved all the stakeholders, including the Edwards family, past families of NICU babies, ACH and FMC staff and AHS, construction began in January 2013. As the construction progressed, a mock up NICU room was made to allow for patient care simulations to occur with the help of KidSim and Human Factors. These simulations provided valuable information about the function of the new space and small modifications were made as construction progressed. Portions of the administrative space have been completed and have opened. Construction completion and operational commissioning of the clinical space will occur simultaneously in the beginning of 2014, followed by staff orientation. The NICU is expected to be open for patient care at the end of February 2014.

NICU Mock Up Room and main corridor.

Department of Paediatrics | Annual Report 2013

Section of Nephrology From left to right: Staff: Dr. Wade, Dr. Samuel, Dr. Midgley, Dr. Hamiwka, Dr. Grisaru (back row) Nephrology Residents: Dr. Alsaidi, Dr. Banks, Dr. Alghamdi (front row)

Highlights Physician/Faculty Listing: Dr. Julian Midgley - Section Chief, CME director and UME Deputy Program Director Dr. Lorraine Hamwika - PGME Program Director Dr. Silviu Grisaru Dr. Susan Samuel Dr. James Tee Dr. Andrew Wade

Dr. Susan Samuel

The Section of Nephrology has undergone some workforce challenges this past year with the start of Dr Silviu Grisaru's sabbaticals coinciding with the departure of Dr Tee to Halifax at the end of June. However the section has still been able to continue providing important clinical care to children and their families. Like many of the clinical sub-specialities at the Alberta Children’s Hospital, the vast majority of clinical work is provided in the nephrology outpatient clinic. This clinic attends to approximately 1500 families per year with over 3000 clinic visits. Of highest complexity are the 200+ children in Southern Alberta from families coping with moderate or severe kidney insufficiency, those on dialysis or those who have received kidney transplants. Although this is only about 15% of the children seen it reflects well over 35% of the physician and clinic resources. Monitoring progress with regular clinic visits, blood pressure control and blood chemistry analyses together with attention to growth helps to delay or even prevent dialysis or transplantation. In 2013 four children received a kidney transplant, the youngest being just 2 years of age, bringing the total transplanted at the Alberta Children's

Annual Report 2013 | Department of Paediatrics

Hospital over several years to 56 with the majority receiving living donor kidneys (most from a parent). The care of these patients now extends into adulthood as the section actively participates in the Young Adult Transplant Clinic at the Foothills Hospital. This represents a significant improvement in transition to adult medical care which has been championed by the section with the organisation of the Transition Symposium. The nephrology team are proud of the work they do and the difference they make to children and families with kidney disease.

Children with moderate to severe kidney disease or those on dialysis or with renal insufficiency

200+

85% 15%

children in Southern Alberta coping with moderate or severe kidney insufficiency, those on dialysis or those who have received kidney transplants. Although this is only about 15% of the children seen it reflects well over 35% of the physician and clinic resources.

special feature

Transition Symposium

Increasing numbers of youth with special health care needs are transferred from pediatric health care to adult oriented health care settings each year. It is well recognized that the process of transitioning and transferring to adult-centered care is challenging for adolescents, young adults and their families. While some patients transition well, too many cope poorly and fail to access quality care - leading to devastating consequences.

2. Youth with special health care needs should have individualized transition plans which incorporate elements of successful intervention strategies (improved education and self-management skills, access to transition coordinator in pediatric care, transition clinics, system navigator support in adult care).

Provision of uninterrupted, developmentally appropriate and coordinated care is necessary to ensure best health outcomes in transitioning youth. We convened a one-day symposium to discuss challenges and opportunities to improve transitional care within the Calgary zone in November 2012. A wide range of clinical groups caring for youth and young adults with special health care needs participated in the symposium and registrants totalled over 170 clinicians, researchers and administrators. We prepared and distributed a report summarizing the outcomes of the symposium and recommendations for improving transitional care for youth with special health care needs in Alberta. Visit this page for the entire Transition Symposium report: http://issuu. com/ach_paediatric_department/docs/transition_symposium_ report_oct_29_

3. A method for evaluating the outcomes of patients transferring from pediatric care should be developed.

The most significant recommendations in the symposium report are as follows: 1. Youth with special health care needs should have a family physician identified well before transfer of care.

4. Ensure consistency of transitional care across disciplines and, in particular, provide support for programs which are in desperate need of better transitional care (e.g. mental health services for youth and young adults with special health care needs). Alberta Health Services needs a coordinated strategy to improve transitional care. A smooth coordinated transition will ensure that all children have the best opportunity to achieve their full potential in adulthood. Best transition practice encourages graded medical independence and self-management skills. A well planned and executed transition strategy will reduce health systems costs by decreasing complications and improving health outcomes. Implementing recommendations in the symposium report will require commitment from Alberta Health Services, Alberta Health and all front line clinical programs. Â&#x2DC; Â&#x2DC; Â&#x2DC;

Department of Paediatrics | Annual Report 2013

Section of Neurology FromFaculty from left-to-right: Jeffrey Buchhalter, Morris Scantlebury, Harvey Sarnat, Karen Barlow, Adam Kirton, Laura Flores-Sarnat, Luis Bello-Espinosa, Alice Ho, Michael Esser, Jong Rho; not pictured: Jean Mah, Alison Moore

Physician/Faculty Listing: Dr. Jong M. Rho - Section Chief Dr. Karen Barlow Dr. Luis Bello-Espinosa Dr. Anita Datta Dr. Michael Esser - PGME Program Director” Dr. Laura Flores-Sarnat Dr. Heather Graham Dr. Robert Haslam Dr. Alice Ho Dr. Adam Kirton Dr. Jean Mah Dr. Aleksandra Mineyko Dr. Alison Moore Dr. Harvey Sarnat Dr. Morris Scantlebury Dr. Kim Smyth

Overview: The Section of Pediatric Neurology based at the Alberta Children’s Hospital (ACH) provides neurological care to the children of southern Alberta and neighbouring Saskatchewan/British Columbia. Dr. Jong Rho leads a dozen faculty child neurologists and an extensive team of trainees and allied health professionals. Excellence in clinical care and research spans all elements of child neurology including: Epilepsy, Neurotrauma and Stroke, Headache, Demyelinating & other Neuro-immune Conditions, Neonatal Neurology & Brain Malformations, Neuromuscular & Movement Disorders, as well as Developmental & Cognitive, Neurogenetic & Metabolic Disorders. Clinical Care: Round-the-clock urgent care is provided through inpatient on-call service and outpatient urgent neurology clinics. Integrated collaborations across multiple paediatric specialities provide comprehensive, cross-disciplinary care. ACH Pediatric Neurology cares for over 700 inpatient consults annually. Outpatient clinics have increased to nearly 5,000 family visits per year including general neurology and numerous subspecialty clinics. Multiple clinical innovation projects and quality improvement/assurance initiatives have been regularly implemented. Education: Our RCPSC Residency Training Program remains fully accredited, has grown to 7 residents (among the largest in Canada) and continues to maintain a

Annual Report 2013 | Department of Paediatrics

100% success rate on the Royal College exam. All section members are actively engaged in teaching through undergraduate, medical school, residency, graduate student, and post-doctoral fellowship levels. A rich educational environment now includes >10 academic rounds and conferences per week. Research: Supported by the Alberta Children’s Hospital Research Institute (ACHRI) for Child and Maternal Health and the Hotchkiss Brain Institute (HBI), our Section continues to experience significant academic growth. Major operating and program grants are held from agencies including CIHR, NIH/NINDS, AIHS, HSFC, NeuroDevNet, CPIRF, and ACHRI. Further, multiple knowledge translation initiatives have directly impacted the clinical care of families.

Highlights include: • >$1.5million in active external funding (brain metabolism, neurotrauma & stroke programs) • >40 peer-reviewed original papers, >12 book chapters, and >80 scientific abstracts • >30 invited presentations at major national / international meetings • >200% growth in research trainees across diverse levels and disciplines

special feature

Calgary Childhood Traumatic Brain Injury Program

HIGHLIGHTS The Calgary Childhood Traumatic Brain Injury Program is a comprehensive clinical assessment, treatment and rehabilitation program. Our mission is to provide exceptional care for children with Traumatic Brain Injury and Complex Concussion. Our goals are to facilitate access to health care, enhance community and educational integration and ultimately improve long-term outcomes. Traumatic Brain Injury is the commonest cause of neurological disability and affects as many as one in five children before the age of 16. Every year the Alberta Children’s Hospital treats over 1500 children with TBI. Many of these children have a mild TBI, often called concussion. A brain injury is often called a “silent” injury, as usually there are few external signs of an injury or trauma and motor recovery is relatively good. This means that they look the same as everyone else. However, many children have severe and frequent headaches, mood and personality changes, difficulties at school (often with an odd mix of abilities and disabilities) and perhaps most importantly they have great difficulty making and sustaining friendships. Our program spans from the Emergency Room, Inpatient Unit, Gordon Townsend Rehabilitation School, to the Traumatic Brain

Injury and Calgary Complex Concussion Clinic (TBI and 4C clinic). We also have an outreach component that extends to schools and the community. We are a multidisciplinary inpatient and outpatient team of health care professionals, clinicians, educational consultants and researchers. This allows us to provide the necessary complex care to this highly variable group of children and their families. As with many programs, the bulk of our work is in the outpatient clinic and we run 3-4 outpatient clinics and one neuropsychological diagnostic clinic per week. Our outpatient team includes neurologists Dr. Karen Barlow and Dr. Mike Esser, Dr. Vithya Gnanakumar (physiatry), Lisette Lockyer and Sarah Shantz (nurse practitioners), Lisa Bodell (TBI clinic nurse), Carol Johnson (school liaison) and Brian Brooks (neuropsychology). We collaborate with schools, university sport medicine clinics, mental health services and community professionals so that over time children can integrate into society to their fullest potential. In addition to an extensive clinical program, we believe that research is crucial to improve outcomes for children and families. At the very heart of this program lies clinically meaningful translational research and education. Dr. Karen Barlow is the operations and research director of the clinical program at the Alberta Children’s Hospital. Our

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

research focuses on several areas including the assessment and management of complex concussions and TBI, including social functioning, the exploration of novel biomarkers, as well as outcomes from pharmaceutical and non-pharmaceutical treatment trials. In this regard, Dr. Barlow has recently been awarded a CIHR team grant to perform a randomized placebo-controlled treatment trial for children who have persistent post-concussion symptoms at one month post-injury called the Play Game Trial (Post Concussion Syndrome in Youth: the GABAergic effects of Melatonin).

Dr. Karen Barlow, photo courtesy of Riley Brandtl

Computerized and novel assessment methods are also being explored in the TBI 4C clinic. These assessments include rapid neuropsychological testing (especially for children complaining of memory impairment), and vestibular and balance testing with a view to providing easy and rapid assessment tools for community practitioners. With the recent appointment of Dr. Michael Esser as a clinicianresearcher in Neurotrauma we not only enhanced clinical capacity for the TBI program but also now have an established translational TBI laboratory in ACHRI. This laboratory is focused on gaining a better understanding of the fundamental factors that affects outcomes in pediatric brain injury using the principle of basic science modeling linked to clinical biodiagnostics. This is

Annual Report 2013 | Department of Paediatrics

an exciting expansion of our program as the laboratory is the first of its kind in Western Canada and one of only a few in Canada, which allows us to bring true bedside-bench-bedside research to pediatric TBI in Calgary.

Section of Oncology

Highlights Physician/Faculty Listing: Dr. Doug Strother – Section Chief Dr. Ron Anderson Dr. Greg Guilcher Dr. Lucie Lafay-Cousin Dr. Victor Lewis Dr. Aru Narendran Dr. Kathy Reynolds – Long-term/Follow up clinic Dr. Tony Truong

The Division provides compassionate and comprehensive care to general- and neuro-oncology patients, to children undergoing hematopoietic stem cell transplant (SCT), and to long-term survivors of childhood cancer and SCT therapy. In the academic year 2012-2013 we were well staffed, and advanced our clinical, education and research programs. All of our work is in partnership with the multidisciplinary, multiprofessional Hematology, Oncology and Blood and Marrow Transplant Program of Alberta Children’s Hospital. We are generously supported by the Alberta Children’s Hospital Foundation, the Childhood Cancer Collaborative and Kids Cancer Care Foundation of Alberta. The research lab or Dr Aru Narendran was officially designated as the POETIC Lab for Pre-Clinical and Drug Discovery at the University of Calgary. It plays a fundamental role in most of the POETIC clinical trials of new agents. Members of the Division hold several leadership roles in national and international consortia: Drs Lafay-Cousin, Guilcher, Strother and Lewis in the Children’s Oncology Group; Drs Strother and Lewis in C17; Dr Narendran in POETIC. As well, within administration, Dr Anderson

holds the position as Deputy Director, Education, Department of Pediatrics. We welcomed Dr Gurpreet Singh as a Paediatric oncology clinical associate. Dr Singh completed Paediatric heme/onc training with us in June 2012. An pilot initiative with Alberta Health Services called Hospital at Home was initiated to provide selected outpatient clinic care in patients’ homes. This program was funded through the Childhood Cancer Collaborative (CCC). Hospital at Home is meant to reduce the costs of care that families accumulate during months’ long cancer care, and to reduce the burden of care within our limited clinic space. Evaluation of the pilot project is underway. Current Issues Challenges for the year included 1) our limited outpatient clinic and day-treatment area spaces within the clinic space that we share with Paediatric hematology, immunology and allergy; 2) evaluation of programs newly instituted or augmented through the Childhood Cancer Collaborative; and 3) transition of support of CCC initiatives to Alberta Health Services in an environment of limited resources.

Department of Paediatrics | Annual Report 2013

Research Highlights Division members contributed to a record number of peer-reviewed publications. The number of research studies onto which we accrue patients is also at an all-time high. The 3rd Annual Paediatric Oncology Research Day was held in November in at Hotel Alma. This year the day incorporated oral presentations of research proposals that competed for funding by the Kids Cancer Care Research Chair. Dr Narendran is a member of the Conjoint Health Research Ethics Board, a duty that involves considerable time for scientific and ethical review of research proposals. Program We provide care to patients in four broad areas: general oncology, neuro-oncology, blood and marrow transplant and long-term survivorship. University of Calgary Endowed Chair Under the Kids Cancer Care/ Alberta Children’s Hospital Foundation Chair in Paediatric Oncology, a competition was held for research grant funding. Drs. Carol Schuurmans, Kathy Reynolds, Nancy Moules

Annual Report 2013 | Department of Paediatrics

and Nicole Culos-Reed were awarded funding for their respective proposals. Education Programs All of the physicians in the Division provide teaching to medical students and Paediatric residents in the in- and outpatient oncology settings. Undergraduate honours students and candidates for Master’s and Doctoral degrees are supervised by members of the Division. Dr Narendran supervises postdoctoral students in his laboratory. As well, all members contribute to the education and evaluation of subspecialty residents in the Paediatric Hematology Oncology Training Program at Alberta Children’s Hospital. Drs Ravi Shah and Anjali Kamra commenced training on July 1, 2012.

From left to right: Dr. Tony Truong, Dr. Ron Anderson, Dr. Lucie Lafay-Cousin, Dr. Greg Guilcher, Dr. Doug Strother, Dr. Victor Lewis

Section of Palliative Care

Highlights Physician/Faculty Listing: Dr. Marli Robertson - Section Chief Dr. Mala Arasu Dr. Leonie Herx Dr. Kevin Levere Dr. Sharron Spicer

The Children’s Hospice and Palliative Care Service (CHaPS) continues to provide comprehensive palliative care to children with serious illnesses and their families, at all the acute care sites in Calgary Zone, in the community and at Rotary Flames House. We also provide respite stays at Rotary Flames House to give parents short breaks from the intensive medical care they need to provide to their children 24/7 in their own homes. A new initiative has been the development of day programming specifically designed for children with progressive life threatening conditions. This includes pet visits, music groups, day trips and many other recreational opportunities. Such activities are readily available for healthy children and their siblings but much less accessible to children who are medically fragile. We have continued to care for many dying children and their families. Our grief support coordination and bereavement service has been particularly active this year with the development of new bereaved parent groups as well as continuing to provide one on one counselling for many. The bereavement service is offered to all parents who have suffered the death of a child who has in any way been connected with ACH during their life time. Section Members provided service on many committees at ACH and have been increasingly involved in providing

leadership to increase awareness and understanding of palliative care for children and to improve the care of children with life threatening medical complexity at a Provincial and National level. • Department of Paediatrics Residency Training Committee ( Member) • ACH Ethics Committee ( Member) • ACH Safety committee ( Member) • ACH Quality Committee (Chair) • AHS Provincial Steering Committee for Palliative and End of Life Care • AHS Advanced Care Planning Policy and Process Committee • Canadian Network of Palliative Care for Children ( Executive member) • Canadian Network of Pediatric Hospices (Executive Member) • CAPH-C Community of Practice for Children with Medical complexity – Member • Canadian Society of Palliative Care Physicians ( Executive) • Royal College Conjoint Advisory Committee for Palliative Medicine ( Members).

Department of Paediatrics | Annual Report 2013

Section of Respirology

Highlights Physician/Faculty Listing: Dr. Mark Anselmo – Section Chief

The Section of Respiratory Medicine had a great 2013 with major changes either completed or newly implemented in almost all of our clinics.

Dr. Marielena DiBartolo – PGME Program Director

The Asthma team continues to roll through 2013 with a new clinic at the South Health Campus.

Dr. Michelle Bailey (Primary appointment in Hospital Paediatrics)

The Sleep team has developed internally an innovative model in clinic to allow the allied health professionals, (nurses, respiratory therapists and sleep technologists) direct interaction with patients under supervision of the Sleep Physician. This model has had a tremendous effect on our clinic waiting list.

Dr. Candice Bjornson Dr. Glenda Bendiak Dr. Valarie Kirk – Deputy Department Head Dr. Ian Mitchell Dr. Mary Noseworthy

Pulmonary Function Tests

3452

per year in the areas of Spirometry, Lung Volumes etc.

The Pulmonary clinic is now re-booking patients in “real-time” decreasing missed return appointments and increasing clerical efficiency. The Cystic Fibrosis clinic underwent successful accreditation from CF Canada. The Respiratory Home Care Clinic has continued to provide excellent care to the most complex and fragile patients. The Section has initiated a joint venture in having a respirologist attend Sickle Cell Clinic to minimize the number of visits for those families.

Annual Report 2013 | Department of Paediatrics

Mahir Ahmed Abdulla undergoing spirometry testing, a type of pulmonary function testing that is particularly useful for diagnosing asthma.

Our own Dr. Ian Mitchell accepted both the Calgary Medical Students’ Association Gold Star Award for Exceptional Classroom Instruction in Ethics as well as the prestigious William Marsden Award from the Canadian Medical Association for his legacy in medical ethics. The Section continues to provide comprehensive Sleep testing and Pulmonary Function Testing to most of the Southern Sector.

Polysomnography

500+

overnight studies, in children, in one of 4 bed laboratories

special feature

Asthma Program

Pediatric asthma in the Calgary Zone (with >45,000 affected) is a collaboration between the Community Pediatric Asthma Service (CPAS), Asthma Specialty Clinic (ASC), Pulmonary Function Testing Lab at Alberta Children’s Hospital (ACH), the Department of Family Medicine (DFM), Community Pediatrics and the Respiratory Clinical Network (RCN) (“the TEAM”). Asthma is the most common chronic disease of childhood.

• RCN asthma pathway Implementation resulted in a 90% increase at ACH and 60% in all other facilities in MDI/ Spacer use – a best practice implementation

TEAM Improvements:

• ASC appointments booked in real time (at end of current visit), enchancing clinic efficiency and family satisfaction

• Online development/implementation of RCN provincial pediatric asthma pathways

TEAM Achievements - Provincially, Nationally and Internationally:

• New referral form for the Zone (triage, transfer and discharge guidelines)

• RCN received the Alberta Health Services Presidents Excellence Award in Research 2013

• DFM resident asthma education with CPAS partnership (2012-2013)

• Six oral presentations at the 21st World Congress of Asthma in Quebec City

• Pediatric Asthma website with education information/ tools/demos in 13 languages and 100,000 hits in 2010

• Zone pediatric asthma pathways (RCN) development led to the first provincial pediatric pathway for ER implemented online across pilot Alberta Emergency Departments in 2013 – the first in Canada

• Asthma database capacity for real time delivery of personlaized action plans and prescriptions TEAM Outcomes: • Reduction to #9th reason for emergency visit and #7th reason for admission (Annual Child Heath Report

2011/2012) despite a 13% increase in the Zone pediatric population since 2005

• CPAS coordinator, Shirley van de Wetering BSc MBA, was one of only 2 recipients of the Alberta Medical Association’s 2012 Medal of Honor, its highest honor for non-physicians.

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

Section of Rheumatology

Highlights Physician/Faculty Listing: Dr. Susa Benseler Dr. Nicole Johnson Dr. Heinrike Schmeling Dr. Tommy Gerschman (locum tenens) Dr. Nadia Luca Dr. Paivi Miettunen

The Section of Rheumatology had an outstanding academic year. We are very proud to report that we increased our (wo)man power and have grown to five physicians. Early this fall, we had a very successful retreat resulting in an innovative care model for in and outpatients in Rheumatology, which we are aiming to implement along with the nursing team in January 2014. Furthermore, we successfully completed the first important step of University of Calgary approval for our urgently needed Paediatric Rheumatology Residency Program. A huge thanks to all of you in the different sections, to Pam and Allison our fearless admin team and the leadership at ACH for guidance and support. We have and will continue to reach out to the many brilliant clinicians, educators and researchers at ACH for joint care models, cross-disciplinary educational events and collaborative research endeavors. Our

Annual Report 2013 | Department of Paediatrics

Dr. Nadia Luca, Dr. Paivi Miettunen, Dr. Heinrike Schmeling, Dr. Nicole Johnson, Dr. Susa Benseler

clinical and translational research programs including neuroinflammation, morphea, systemic vasculitis and lupus, transition, early arthritis and autoinflammation are a tremendous source of learning hopefully resulting in patient outcomes. We are also closely aligned with our fantastic adult rheumatology colleagues led by Dianne Mosher. For years, we have worked together with young adults who have rheumatic diseases at the (YARD) clinic. More recently seed for new joint initiatives have been laid. Together, we hold superb educational rounds and are engaged in important research in rheumatic disease.

Research Unit - Behavioural Research Unit

Highlights Faculty Listing: Dr. Deborah Dewey – Unit Chief Dr. Gerald Giesbrecht Dr. Bonnie Kaplan

Dr. Gerald Giesbrecht - Alberta Pregnancy Outcomes and Nutrition (APrON) What a pregnant woman eats and drinks and the chemicals she is exposed to have direct effects on her baby’s development. That much seems obvious. But what about the impact of her psychological and social experiences? Do feelings of depression and anxiety or the secure feeling of being loved and supported somehow become incorporated into a baby’s biology? If so, how are these ‘stress signals’ transduced from a woman’s experiences into her baby’s development and why are not all babies affected equally? These are the kinds of questions that Dr. Gerry Giesbrecht is investigating in a series of studies based on the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort. So far the results have provided crucial evidence linking pregnancy stress to increases in cortisol which then seems to put baby’s stress systems into overdrive. It has been widely reported that pregnant women become less reactive to stress as pregnancy progresses and that this reduction in stress reactivity is a protective mechanism that shields the baby from maternal cortisol. Dr. Giesbrecht’s recent work shows that this is not the case: stress-related increases in cortisol are maintained throughout pregnancy. Fortunately, however, there are

ways to help shield the baby from maternal stress. We know, for example, that social relationships can buffer the effects of stress on child development. Indeed, a recent study conducted in Dr. Giesbrecht’s lab found that women who have highly supportive partners have smaller increases in cortisol when they experience a stressor compared to women with less supportive partners. These changes in maternal stress physiology have implications for the development of her baby. The ultimate aim of this research is to determine both the mechanisms by which maternal stress during pregnancy gets ‘under the skin of babies’ and the ways that we can interrupt or buffer these effects.

Department of Paediatrics | Annual Report 2013

special feature

Global Child Health Unit

VISION: A World Where Children Can Survive And Thrive MISSION: Collaborating To Promote Global Child Health Through Innovative Clinical, Educational And Research Activities

The creation of the Global Child Health Unit (GCHU) is a new addition within the Department of Paediatrics under the current leadership of co-directors Drs. Jean-Francois Lemay and Dr. Nalini Singhal. Approximately 65-70 members of the Department have joined the Unit. The first meeting of the GCHU was all about getting the Unit off the ground and as such one of the first orders of business was to resolve the unit’s Mission and Vision. The goal of the GCHU is to discuss and share ideas about current and future international projects. Provide a venue for likeminded individuals to work together to support clinical, education and research activities.. In addition, the GCHU increase knowledge dissemination in the area of international health. And assist in training the future leaders in global child health. There is a lot of interest within the Department of Paediatrics amongst GFT, as well as clinical members including Community Paediatricians and Residents. Currently short and long-term objectives are being developed with input from all interested individuals and there is support to develop some new programs that would involve a cross section of members. A mechanism to support ongoing programs will be developed. The GCHU will work closely with Global Health & International Partners at the Faculty of Medicine and University of Calgary.

Annual Report 2013 | Department of Paediatrics

Physician/Faculty Listing: Dr. Susa Benseler Dr. Dana Boctor Dr. Carrah Bouma Dr. Jenn Brenner Dr. Adeline Brimacombe Dr. Jeffrey Buchhalter Dr. Decker Butzner Dr. Ciara Chamberlain Dr. David Chaulk Dr. Caroline Chee Dr. Adam Cheng Dr. Amy Chow Dr. Suzette Cooke Dr. Deborah Dewey Dr. Frank Dicke Dr. Meagan Doyle Dr. Julie Fisher Dr. Charlotte Foulston

Dr. Janis Friesen

Dr. Cheri Nijssen-Jordan

Dr. Ben Gibbard

Dr. David Patton

Dr. Vithya Gnanakumar

Dr. Bev Prieur

Dr. Roxanne Goldade

Dr. Ted Prince

Dr. Jennifer Graham Wedel

Dr. Jack Rabi

Dr. Barbara Grueger

Dr. Nipunie Rajapakse

Dr. Anne Hicks

Dr. Dan Ross

Dr. Matt Hicks

Dr. Amonpreet (Preet) Sandhu

Dr. Sara Jassemi Dr. Kristen Johnson Dr. Majeeda Kamaluddeen Dr. Gurpreet Khaira Dr. Susan Kuhn Dr. Linda Loovere Dr. Paola Luca Dr. Jennifer MacPherson Dr. Jean K. Mah Dr. Danielle Nelson Dr. Polya Ninova Dr. Alberto Nettel-Aguirre

Dr. Reg Sauve Dr. Anna Serebrin Dr. Gurpreet Singh Dr. Nalini Singhal Dr. Amuchou Soraisham Dr. Amelie Stritzke Dr. Heather Thompson Dr. Joseph Vayalumkal Dr. Andrew Wade John Wu Dr. Melanie Willimann Dr. Karin Winston

Research Team - Research Methods Team

Highlights Faculty Listing: Dr. Gillian Currie – Unit Chief Dr. Brent Hagel Dr. Alberto NettelAguirre

A key accomplishment for the Research Methods Team this year is the successful funding in April 2013 of the “Alberta Program in Youth Sport and Recreational Injury Program” through the highly competitive Alberta Innovates Health Solutions (AIHS) Collaborative Research Opportunity (CRIO) Program grant competition. We have selected this as a highlight because it is an effort involving all members of the Research Methods Team in collaboration with researchers in other Faculties at the University of Calgary, as well as across Canada. This program is co-led by Dr. Hagel from the Research Methods Team, and Dr. Carolyn Emery (Kinesiology and cross appointed in Paediatrics as well). Drs. Currie and NettelAguirre are also collaborative members of the team. Dr. Hagel’s former trainees also are playing important roles in this CRIO - Former PhD student Dr. Kelly Russell from University of Manitoba is a team member and former MSc student, and RMT research assistant, Nicole Romanow is playing a critical role as Research Coordinator. About the research program: In children and adolescents, participation in sport and recreational activity is a key part of maintaining a healthy lifestyle. Childhood physical activity promotes healthy growth and development and prevents chronic disease.

On the other hand, sport and recreation is the leading cause of injury in youth, and many of these injuries require medical attention. The ultimate goal of the Alberta Program in Youth Sport and Recreational Injury Program is to reduce the burden of sport and recreational injuries in youth in Alberta. The specific objectives of the research program are: 1. to develop and evaluate programs and policies in injury prevention in youth sports and recreation focusing on activities with high participation and high burden of injury in Alberta a. evaluate body checking policy changes in youth ice hockey b. evaluate age-related participation policies in school ski and snowboard programs and develop and evaluate an injury prevention component to accompany these programs c. evaluat the effectiveness of a curriculum-based injury prevention program in the junior high school setting. 2. To build research and KT capacity in youth sports and recreational injury prevention.

Department of Paediatrics | Annual Report 2013

special feature

Sleep-Epilepsy Research Project

The sleep epilepsy program team: Dr.Alice Ho, Silvia Kozlik, Leah Schmalz, Elizabeth Bourque, Dr. Glenda Bendiak, Adetayo Adeleye, Dr. Valerie Kirk and Jeff Buchhalter (not shown).

The Sleep-Epilepsy Integration Pilot Project was created to test the feasibility of combining the Pediatric Sleep Diagnostic Service and the Epilepsy Seizure Monitoring Unit into an integrated effort for selected children. Our hope is to demonstrate more effective and efficient patient care delivery through an innovative approach to the clinical/biological overlap between sleep and epilepsy disorders.

As part of the overall project, we felt it was essential to include a research component by which knowledge would be created regarding the interactions of sleep and epilepsy. To this end, two studies are proposed. ¡ How frequently is epileptiform activity found in small children w ho are referred for a routine sleep study, polysomnogram (PSG)? Does abnormal brain electrical activity or seizures contribute to sleep problems? ¡ How does the sleep cycle relate to abnormal electroencephalographic (EEG) activity and seizures in children that are admitted to the Pediatric Epilepsy Monitoring Unit (PEMU) with regard to respiratory and cardiac function? What are the implications of these relationships to Sudden Unexplained Death In Epilepsy Patients (SUDEP) – an uncommon but devastating complication of epilepsy? First Steps: We are systematically reviewing all the polysomnogram studies that we have performed in infants in the

Annual Report 2013 | Department of Paediatrics

past few years and taking special attention to quantify what sort of sleep problems they were found to have, as well as looking for evidence of EEG abnormalities. Very little is known about sleep physiology in infants and we plan to build on this knowledge. Impact: Our collaborative work will provide further training to both sleep and EEG laboratory physicians and technicians. It will allow for a more systematic process of identifying epileptiform discharge that may prompt referral to the neurology department for further evaluation. It will help us to identify children who may benefit from a combined sleep/EEG diagnostic study from those who need only one of these investigations. The information acquired during these projects could have a direct and immediate effect on the children of Alberta as the rate of SUDEP in those with intractable epilepsy is approximately 1 in 100. Our results could serve as the basis for a trans-Canadian study funded by a CIHR and establish ACH as a world leader in pediatric SUDEP research.

Maternal and Child Team - Dr. Suzanne Tough

Highlights Faculty Listing: Dr. Suzanne Tough

Education, Research and Service to Society • Principal Investigator of the All Our Babies Study, a multidisciplinary, collaborative longitudinal cohort of 3,200 maternal child pairs investigating the causes and implications of preterm birth and the early influences of child health and family well-being. • Completed data collection for AOB participants at age 24 months and completed extensive collaborations and preparation of a new questionnaire for follow-up at 5 years of age, as well as a follow-up questionnaire to investigate the impact of the June floods in southern Alberta. • Supervised the successful defence of one PhD and one Master’s students, in addition to continued supervision of 5 post-doctoral fellows as well as one new PhD and one new Master’s students, contributing to the training of the next generation of innovative researchers in maternal and child health. • Continuing as the Scientific Director of the Alberta Centre for Child, Family and Community Research to

oversee the development of research and knowledge dissemination activities, ensuring scientific excellence and community relevance, as well as facilitating dialog and partnerships between researchers, policy makers and service providers to promote relevant research and evidence informed decision making. • Published the Preterm Birth and Healthy Outcomes Team (PreHOT) supplement in BMC Pregnancy and Childbirth featuring 5 articles from the All Our Babies team and an additional 8 articles from other members of the PreHOT tem, representing the culmination of 5 years of team research. Services Provided: Dr. Tough has provided service to the University of Calgary, Alberta Health Services, the academic community and the broader community in several significant ways. She participated in a variety of committees that contribute to the knowledge and operations of the Alberta Children's Hospital (n=1), the University of Calgary (n=1) and Alberta Health Services (n=3), including the Alberta Health Services' Women's Reproductive/ Preconception Health Committee.

Department of Paediatrics | Annual Report 2013

Further, Suzanne serves on a variety of international, national and local committees, including: PREBIC (World Health Organization), the Institute Advisory Board for the Institute of Aboriginal Peoples' Health (Canadian Institutes of Health Research, Frontiers of Innovation (a crosssector, cross-disciplinary collaboration with the Alberta Family Wellness Initiative and the Harvard Center on the Developing Child), the Canadian Child Health Clinician Scientist Program, the Upstart Council of Champions (United Way of Calgary), and the Scientific Advisory Panel for Assisted Human Reproduction Canada Board. She participated as a peer reviewer for professional and salary applications, and for both external and internal grant applications, including the Alberta Innovates Health Solutions Post-Graduate Fellowship Review Committee. Suzanne also serves the health community through ongoing peer reviews of manuscripts submitted to a variety of journals in relevant areas. Further, Suzanne contributed to the continuing education of investigators, policy makers and the public via invited addresses and workshops (n=5), book chapters (n=3), and peer-reviewed publications (n=19).

Annual Report 2013 | Department of Paediatrics

Paediatric Clinical Activity in Calgary Zone Facilities ACH Inpatient Discharges 8,000 7,800

7,872

7,600

Discharges

Excerpts from Child Health Annual Report 2012/13

53%

7,400 7,200 7,000 6,800

7,344

7,341 7,075

of the ACH Inpatients Activity by Most Responsible Physician were under the Department of Paediatrics

6,909

6,600 6,400 6,200 12/13

11/12

10/11

09/10

08/09

6,000

Child Health Annual Report 2012/13 ACH Activity Activity - -5 5Year ACH yearTrends Trends Fiscal Yr Discharges Total Days Stay (LOS) PICU Cases ED Visits Day Surgery Ambulatory face to face Unique Patients (Inpt & Outpt)*

08/09 7,075 38,424 791 55,954 7,050 225,037 74,172

09/10 6,909 36,897 733 59,170 6,832 228,531 76,821

10/11 7,341 38,981 780 59,639 6,760 223,840 79,863

11/12 12/13 7,344 7,872 40,680 43,902 760 855 65,016 72,719 6,960 6,902 238,172 303,610 216,146 82,512 87,066

Unique patients based on ULI.

8,000- March 31, 2013 April 1, 2012 7,800- March 31, 2011 April 1, 2010 arges

ACH Inpatient Discharges

7,600 7,400 7,200 7,000

Department of Paediatrics | Annual Report 2013 7,872 7,341

7,344

Department of Paediatrics Inpatient Activity at ACH by Most Responsible Physician Section

Medical Divisions

08/09 1 49 35 54 4 141 2,305 15 249 12

Total Days 4 663 36 115 133 845 14,237 52 1,940 59

119 93 517 355 91 5 4,045

589 291 4,776 3,684 740 9 28,173

Discharges Anesthesiology Cardiology Diagnostic Radiology Endocrinology Family Medicine Gastroenterology Hospitalist/Pediatrics Infectious Disease Intensivist Medical Genetics Neonatology Nephrology Neurology Oncology/Hematology Psychiatry Respirology Rheumatology Total - Medical

09/10 ALOS

Discharges

4.0 13.5 1.0 2.1 33.3 6.0 6.2 3.5 7.8 4.9

1 41 21 43 3 136 2,237 5 230 1

Total Days 9 310 31 100 8 1,014 14,340 25 1,635 1

4.9 3.1 9.2 10.4 8.1 1.8 7.0

109 122 436 423 74 11 3,893

522 418 4,230 4,455 754 25 27,877

Annual Report 2013 | Department of Paediatrics

10/11 ALOS

Discharges

9.0 7.6 1.5 2.3 2.7 7.5 6.4 5.0 7.1 1.0

8 34 14 52 3 145 2,489 4 237 8

4.8 3.4 9.7 10.5 10.2 2.3 7.2

80 177 480 483 64 0 4,278

Total Days 25 345 14 118 4 1,010 16,479 26 2,992 12

11/12 ALOS

Discharges

3.1 10.1 1.0 2.3 1.3 7.0 6.6 6.5 12.6 1.5

6 44 16 88 1 155 2,353 8 184 1 69 70 223 526 433 48 0 4,225

375 473 4,039 4,203 669

4.7 2.7 8.4 8.7 10.5

30,784

7.2

Total Days 20 306 17 243 3 973 15,221 22 2,180 1 1,380 378 665 4,314 4,754 515 30,992

12/13 ALOS

Discharges

3.3 7.0 1.1 2.8 3.0 6.3 6.5 2.8 11.8 1.0 20.0 5.4 3.0 8.2 11.0 10.7

2 59 26 103 5 140 2,502 2 259 5 93 133 260 487 528 70 4 4,678

7.3

Total Days 5 532 27 287 15 1,090 15,244 26 2,911 29 2,324 720 767 4,023 6,008 745 5 34,758

ALOS 2.5 9.0 1.0 2.8 3.0 7.8 6.1 13.0 11.2 5.8 25.0 5.4 3.0 8.3 11.4 10.6 1.3 7.4

Total Paediatric Admissions in Calgary Zone

10,000 8,000 ACH-Total (Peds, Sx, MH)

6,000

ACH-Pediatrics PLC-Pediatrics

4,000

NICU-Total Calgary Total Pediatric & NICU

12/13

11/12

10/11

09/10

08/09

2,000

Department of Paediatrics | Annual Report 2013

Total Length of Stay (LOS) Days fo Paediatric Admissions in Calgary Zone

80,000 70,000 ACH-Total (Peds, Sx, MH)

60,000

ACH-Pediatrics PLC-Pediatrics

50,000

Calgary-NICU-Total Calgary Total Pediatric & NICU

40,000 20,000

Annual Report 2013 | Department of Paediatrics

12/13

11/12

10/11

09/10

08/09

10,000

acH inpatient Length of stay trends 2,500

ACH Inpatient Length of Stay Trends

Discharges

2,000

1,500

1,000

500

< 12 Hr

1 Day (12+ Hr)

2 Days

3 Days

4 Days

5 Days

08/09

477

1,931

1,258

819

651

431

286

190

09/10

452

1,921

1,200

869

560

362

265

229

10/11

477

2,157

1,284

856

577

400

268

212

171

11/12

520

2,110

1,201

857

538

416

287

234

164

109

12/13

520

2,285

1,336

864

600

468

285

254

167

142

6 Days

7 Days

9 Days

10 - 14 Days

15 - 19 Days

20 - 24 Days

25 - 29 Days

30 - 34 Days

35 - 39 Days

40 - 49 Days

50 - 99 Days

100+ Days

116

307

165

152

123

338

134

125

351

174

388

174

103

403

174

111

8 Days

Length of Stay Days stay is total number of accumulated inpatient days for patients discharged (including deaths) . The day of admission is counted but not the day of discharge. in and out the same day or the next calender day.

LOS < 12 hours includes patients

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

ACH Inpatient Most Responsible Diagnoses

Code K35 J21 Z51 J35 G40 J45 F32 Z54 J18 S42 R10 E10 G47 T81 F43 S82 R56 Z53 F90 S52 A09 D70 K56 N39 A08 M41

Most Responsible Diagnosis Acute Appendicitis Acute Bronchiolitis Other Medical Care Chronic Diseases Of Tonsils And Adenoids Epilepsy Asthma Depressive Episode Convalescence Pneumonia, Organism Unspecified Fracture Of Shoulder And Upper Arm Abdominal And Pelvic Pain Type 1 Diabetes Mellitus Other Sleep Disorders Complications Of Procedures, Not Elsewhere Classified Reaction To Severe Stress, And Adjustment Disorders Fracture Of Lower Leg, Including Ankle Convulsions, Not Elsewhere Classified Persons Encountering Health Services For Specific Procedures, Not Carried Out Hyperkinetic Disorders Fracture Of Forearm Other Gastroenteritis And Colitis Of Infectious And Unspecified Origin Agranulocytosis Paralytic Ileus And Intestinal Obstruction Without Hernia Other Disorders Of Urinary System Viral And Other Specified Intestinal Infections Scoliosis

S72

Fracture Of Femur

R50 Q54 T18 S06 J05 E84 A41 R62 J06

Fever Of Other And Unknown Origin Hypospadias Foreign Body In Alimentary Tract Intracranial Injury Acute Obstructive Laryngitis [Croup] And Epiglottitis Cystic Fibrosis Other Sepsis Lack Of Expected Normal Physiological Development Acute Upper Respiratory Infections Of Multiple And Unspecified Sites Top 50% Diagnoses

Annual Report 2013 | Department of Paediatrics

Discharges 339 309 296 248 211 208 190 177 149 138 131 106 98 89 87 74 71 71 69 66 62 61 59 57 56 54

Total Days 908 1479 1200 253 932 545 2066 535 582 175 227 277 106 400 595 137 181 74 960 89 145 311 453 335 215 329

ALOS 2.7 4.8 4.1 1.0 4.4 2.6 10.9 3.0 3.9 1.3 1.7 2.6 1.1 4.5 6.8 1.9 2.5 1.0 13.9 1.3 2.3 5.1 7.7 5.9 3.8 6.1

126

2.3

52 51 50 50 49 49 49 47 46 3973

181 78 78 237 119 744 420 457 170 16119

3.5 1.5 1.6 4.7 2.4 15.2 8.6 9.7 3.7 4.1

PLC Inpatient Most Responsible Diagnoses - Top 10 Diagnoses

Code

Most Responsible Diagnosis

Discharges

Total Days

ALOS

P59

Neonatal Jaundice From Other And Unspecified Causes

277

326

1.2

J21

Acute Bronchiolitis

160

478

3.0

P07

Disorders Related To Short Gestation And Low Birth Weight, NEC

1862

19.6

J18

Pneumonia, Organism Unspecified

211

2.4

Top 10 Diagnoses

620

2877

4.6

Department of Paediatrics | Annual Report 2013

annual paediatric Unit occupancy at acH and pLc (excluding nicUs)

Unit NICU

ACH

PLC

PICU

Total

Unit 31

Fiscal Year

Unit 1

Unit 2

24HR

Unit 3

Unit 4

MHINPAT

200809

86.0%

93.6%

72.8%

92.7%

89.5%

86.5%

65.8%

89.5%

73.9%

200910

71.4%

93.7%

61.5%

91.8%

89.4%

94.9%

59.1%

87.1%

73.1%

201011

73.8%

94.1%

57.1%

92.7%

91.8%

89.1%

62.1%

84.0%

72.4%

201112

83.5%

94.2%

63.8%

96.1%

94.7%

92.9%

84.7%

67.3%

88.1%

75.5%

201213

85.2%

93.7%

69.7%

95.8%

92.4%

95.6%

82.4%

75.5%

90.0%

74.0%

ACH Unit Occupancy Fiscal 2012/13 PICU

75.5%

NICU

82.4%

MHINPAT

95.6%

Unit 4

92.4%

Unit 3

95.8%

24HR

69.7%

Unit 2

93.7%

Unit 1 0.0%

85.2% 20.0%

ANNUAL REPORT 2013 | DEPARTMENT OF PAEDIATRICS

40.0%

60.0%

80.0%

100.0%

120.0%

acH picU activity 08/09

09/10

10/11

11/12

PICU Cases

Fiscal Yr

791

733

780

760

12/13 855

Admissions to PICU*

493

465

445

397

435

Transfers Into PICU from Units*

249

235

248

279

294

Transfers Into PICU from ADOP/PACU*

125

138

161

150

156

Discharge from PICU

198

161

150

115

119

Transfers Out of PICU to Units*

609

580

643

664

715

PICU Unit LOS Hospital LOS - PICU Cases Extra-Corporal Life Support cases*

3326

2856

3831

3038

3771

11,681

11,088

12,989

11,554

13,423

n/a

* fiscal year based on hospital admission date, others based on hospital discharge date. Patients may have more than 1 admission, transfer into PICU, and transfers out of PICU on a hospital stay Extra-Corporal Life Support cases* are collected if the the following CIHI criteria are met, effective Apr 2012: - performance in an operating/intervention room (e.g. endoscopy room, cardiac catheterization room) or; - performance in the presence of an anesthetist (i.e. anesthetic record on the chart) or; - performance using the following approaches: open, endoscopic, percutaneous transluminal/transarterial or."

Cases

ACH PICU Cases

1000 900 800 700 600 500 400 300 200 100 0

791

08/09

733

09/10

855

780

760

10/11

11/12

12/13

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

NICU Activity at all Hospitals NICU Indicators

ACH

FMC

PLC*

RGH

Total

11/12

12/13

08/09

09/10

10/11

11/12

12/13

08/09

09/10

10/11

11/12

12/13

08/09

09/10

10/11

11/12

12/13

08/09

09/10

10/11

11/12

12/13

122

1091

1184

1175

1132

1173

782

790

798

809

778

990

1007

1010

1000

1046

2863

2981

2983

3027

3119

Total Days Stay

2317

3913

11573

13356

13678

12789

12620

8833

9209

9505

10009

9736

10349

10814

11047

10306

30755

33379

34230

35421

36575

Average Length of Stay (ALOS)

26.9

32.1

10.6

11.3

11.6

11.3

10.8

11.3

11.7

11.9

12.4

12.5

10.5

10.7

10.9

10.3

9.9

10.7

11.2

11.5

11.7

529

586

647

689

671

662

712

750

808

809

Total Days in NICU Unit

1442

2365

10750

12427

13369

11889

11780

7639

8099

8525

8738

8760

9740

10150

10679

9562

9494

28129

30676

32573

31631

32399

Average Case Weight (ARIW)

9.82

10.59

3.43

3.62

3.66

3.41

3.39

2.22

2.28

2.30

2.36

2.32

2.08

2.03

2.13

2.02

1.91

2.63

2.73

2.78

2.86

2.91

2300

2358

2360

2315

2390

13.4

14.2

14.5

15.3

Discharges

Intracity Transfer

Unique Patients Average Neonatal Length of Stay per Patient (Days)

Annual Report 2013 | Department of Paediatrics

Excerpts from Canadian Neonatal Network (CNN) Annual Report 2012

CNN Sites

We have the highest number of admissions amongst 30 sites and we have the 3rd highest acuity scores (SNAPPE II). With adjustment, our standardized mortality is 1.4% (3.3% mean), our standardized morbidity rate is 33.9% (32.8% mean). Using adjusted odds ratios we are at the mean for ROP, to the left of centre for other outcomes, except for BPD (AOR 1.8) and IVH with an AOR of 1.2. We are reviewing all the cases of IVH from 2012, however in a preliminary review of the first 6 months of 2013, it looks like the IVH rates are coming back to our previous baseline. Our AOR for BPD is 1.8, we are no longer the site at the extreme right. Overall, we are at 21.8% compared to the CNN mean of 15.4%.

Admissions to Canadian Neonatal Network participating centers

²Data collected on selected cohort of eligible admissions only.

Canadian Neonatal Network

¢ ¢

Inborn Outborn

Readmission

Foothills Medical Centre (#30) with highest number of admission among centre in Canadian Neonatal Network (CNN) 2012 Number of admissions  Data collected on selected cohort of eligible admissions only.

Department of Paediatrics | Annual Report 2013

Admissions illness severity scores (SNAP-II and SNAP-IIPE) by site

SNAP-IIPE sandardized site mortality rates

(only for sites that contributed data on all eligible admissions) (n=25 sites, 14 247 admissions, 363 missing data on SNAPP score)

A B

D

SNAPPEII Score SNAPII Score

¢ ¢

L M

R

Foothills Medical Centre (site X), comparison of crude and adjusted mortality in CNN 2012

W X Y Z AA AB AD

U V W X Y Z

Mean Scores

AA AB AC

Per 100 admitted infants ‡ Site R has a crude mortality rate of 18.9% and site AC has a crude mortality rate of 17.5%, but they are not shown completely in the graph. Please refer to table on page 42 for actual persentages for sites R and AC.

Annual Report 2013 | Department of Paediatrics

AD 1

Site

Foothills Medical Centre (site X) with 3rd highest severity of illness scores among centres in CNN 2012

Crude mortality rate SNAPIIPE standarized

mortality rate

Site

¢ ¢

Necrotizing enterocolitis â&#x2030;Ľ stage 2) among neonates with GA, 33 weeks among centres in CNN 2012

Oxygen use at 36 weeks post-menstrual age in neonates with GA, 33 weeks at birth in CNN 2012

Number of neonates: 3 846

Number of neonates: 3 742

Reference site: M

Reference site: Q

Inclusion criteria: GA<33 weeks Age at admission less than 4 days

Inclusion criteria: GA<33 weeks Age at admission less than 4 days Survival to 36 week post-menstrual age or discharee

Significant predictors identified by multivariate analysis and adjusted for: GA Maternal diabetes *Sites significantly different from reference site (P<0.05)

Significant predictors identified by multivariate analysis and adjusted for: GA Male Apgar at 5 minutes SNAP-II Score SGA (BW <10* percentile for GA) *Sites significantly different from reference site (P<0.05)

Department of Paediatrics | Annual Report 2013

Retinopathy of prematurity stage 3 and higher among centres in CNN 2012

Number of neonates: 1 562 Reference site: X Inclusion criteria: GA<33 weeks Screende for ROP Age at admission less than 4 days Site Z was not included in thes analysis due to the small number of neonate who meet the includion criteria Significant predictors identified by multivariate analysis and adjusted for: GA SGA(BW<10* centile for GA) *Sites significantly different from reference site (P<0.05) Outcome is attributed to the network site of first admission

Annual Report 2013 | Department of Paediatrics

ACH Emergency Department Visits 80,000 75,000

ED Visits

70,000

72,719

65,000

65,016

60,000 55,000

Child Health Annual Report 2012/13

59,639

59,170

55.954

ACH Emergency 50,000 Department Visits 11/12

12/13

65,016

72,719

ACH Emergency Department Visits

11/12

10/11 59,639

12/13

80,000

09/10 59,170

08/09

40,000

08/09 55,954

10/11

ED Visits

09/10

Fiscal Yr45,000

75,000

Visits

70,000

72,719

65,000

Child Health Annual65,016 Report 2012/13

60,000 55,000 50,000

59,639

59,170 55,954

ACH Emergency Department Visits Visits ACH Emergency Demartment 45,000

Fiscal40,000 Yr ED Visits

08/09

08/09 55,954

09/10

10/11

11/12

59,170

59,639

65,016

09/10

10/11

11/12

12/13 72,719

12/13

ACH ED Tier 1 Measures - Fisical 2012/13 ACH ED Tier 1 Measures - Fiscal 2012/13: ACH

Emergency Department Visits

80,000

# Met Target

ED Visits (Den)

% Met Target

Avg Time

Median Time

3128

4839

64.6% 72,719

8.5 hours

6.5 hours

Discharged 65,000 (target: within 4 hours)

64699

65695

98.5%

2.8 hours

2.3 hours

Triage to Physician for CTAS 2 patients (target: 30 minutes) 60,000

4264 65,016

7038

60.6%

33 min.

25 min.

12930

32452

39.8%

90 min.

74 min.

Admission 50,000Request to Admission (target: 90 minutes)

2059

4587

44.9%

218 min.

99 min.

Bed Allocation to ED Departure (target: 30 minutes) 45,000

1445

4838

29.9%

58 min.

45 min.

Tier 175,000 Measures

Visits

70,000 Admitted (target: within 8 hours)

59,170 60 minutes) Triage to Physician for CTAS 3 patients (target: 55,000

59,639

55,954

40,000

08/09

09/10

10/11

11/12

Department of Paediatrics | Annual Report 2013

ACH ED Tier 1 Measures - Fiscal 2012/13: Tier 1 Measures Admitted (target: within 8 hours)

12/13

# Met Target

ED Visits (Den)

% Met Target

Avg Time

Median Time

3128

4839

64.6%

8.5 hours

6.5 hours

acH eD Visits by ctas score

Resusc

10%

Emergent Urgent

39%

Semi-Urgent Non-Urgent

48%

Unknown

Resusc

Emergent

Urgent

Semi-‐Urgent

Non-‐Urgent

Unknown

Child Health Annual Report 2012/13 acH emergency Demartment Visits by ctas score

ACH ED Visits by CTAS Score

CTAS Triage Level 1 - Resusc 2 - Emergent 3 - Urgent 4 - Semi-Urgent 5 - Non-Urgent 9 - Unknown Total

ED Visits 349 7548 34574 28556 1673 19 72719

% Total 0.5% 10.4% 47.5% 39.3% 2.3% 0.0% 100.0%

ED Visits by CTAS Score 2%

1% 10%

ANNUAL REPORT 2013 | DEPARTMENT OF PAEDIATRICS

39%

1 ‐ Resusc 2 ‐ Emergent 3 ‐ Urgent 4 ‐ Semi‐Urgent

ACH Paediatric Ambulatory Care Visits ACH Paediatric Ambulatory Care Visits #

Program Supported Description

218

(Ach) Youth Health Program Adolescents

994

Aboriginal Liaison

178

Acets Program

Ambulatory Services On Tcluster

Asthma Clinic

Unique Patients

F1213

577

173

884

178

6277

1553

933

Bereavement And Palliative Care

551

163

126

Brain Injury

671

277

Cardiology Clinic

6881

4323

Cardiology Clinic (by program_no)

2823

2286 401

103

Child Abuse Program (Ach)

1985

138

Cope Program

202

Cystic Fibrosis Clinic

3778

156

Diabetes Clinic (Ach)

8236

974

139

Eating Disorders Program

22936

374

Endocrinology Clinic

3685

1064

171

Fetal Alcohol Syndrome

178

12896

2809

Gastroenterology

Gastroenterology (by program_no)

118

112

Genetics

3571

2804

117

Hematology Clinic

1373

461

Hemophilia Clinic

269

Infectious Disease Clinic

299

235

110

Medical Day Treatment (Ach)

190

Metabolic Disease Clinic Ach

2289

472

10156

4672

Nephrology Clinic

821

Neuro Oncology Clinic

427

Neurology Clinic

6642

2412

Neuromotor Clinic

4506

716

Neuromuscular Clinic

1148

185

Oncology

9611

677

939

Parenteral Therapy Program

205

127

156

Pediatric Centre For Weight And Health (Ach)

1093

163

Pediatric Neuro Developmental Clinic

2974

1207

1895

844

818

Pediatric Sleep Lab

134

Peds Behavioral And Development Clinic

Perinatal Clinic

4547

772

1634

560

Pulmonary Clinic

204

Renal Ach Hemodialysis

204

Renal Ach Hemodialysis (by program_no)

416

Respiratory Home Care

4339

526

Respiratory Services

2610

901

Rheumatology Clinic Total

All Visits

1028

351

133711

52666

Department of Paediatrics | Annual Report 2013

Annual Report 2013 | Department of Paediatrics

Department of Paediatrics | Annual Report 2013

Education and Training Programs

Overview

OVERVIEW

Undergraduate Medical Education (UME)

Education at all levels is a fundamental priority for the Department of Paediatrics and all members are expected to participate in direct teaching and/or education leadership throughout the Department, within the Faculty of Medicine, AHS and in the broader community. The Department of Paediatrics is very proud of the accomplishments of its members in paediatric education. Many educational innovations are occurring and being recognized locally as well as nationally and internationally.

Post Graduate Medical Education (PGME) Continuing Medical Education (CME)

Paediatric undergraduate medical education is woven throughout the three years of the University of Calgary medical school curriculum, with a combination of didactic and clinical teaching. Post Graduate Medical Education is delivered primarily through the General Paediatrics Residency Training Program, as well as through eleven other Royal College affiliated Residency Training Programs. All programs received full Royal College accreditation at the last RCPSC external review in 2009.

Some faculty members participate in undergraduate education though the O’Brien Bachelor of Health Science program at the University of Calgary. Numerous faculty members participate as supervisors and committee members for MSc, PhD and postdoctoral programs throughout the Faculty of Medicine. In recent years, Paediatric Simulation education has been especially important in providing hands-on learning to all levels of learners as well as practicing health care professionals. A new simulation centre is opening January 8th 2014 at ACH (KidSIM, Pediatric Patient Simulation Program) to further assist in this area of paediatric education.

Continuing Medical Education is a vital part of paediatric education and contributes to paediatric learning not only within Calgary, but also to physicians via telehealth throughout southern Alberta and southeastern British Columbia.

Annual Report 2013 | Department of Paediatrics

Undergraduate Medical Education (UME)

UME Director and Clerkship Director: Dr. Susan Bannister UME Deputy Director and Clerkship Deputy Director: Dr. Julian Midgley Clerkship Evaluation Coordinator: Dr. Nicole Johnson

Paediatrics is taught throughout Years 1 and 2 of the University of Calgary medical school curriculum (which is three years in duration). The largest amount of paediatric teaching occurs in the Women’s and Child Health course. This course, co-chaired by Dr. Marielena DiBartolo, introduced paediatric clinical skill training for all students since 2012. This Course allows students early exposure to paediatric clinical skills for patients of all ages.

The other three weeks will be a combination of (usually) two of the following:

In Year 3, the clerkship year, students rotate through different rotations and spend six weeks learning paediatrics. Our curriculum, based on the national undergraduate paediatrics curriculum, is highly regarded by most students. Most students will complete a threeweek rotation in general paediatrics in one of the three locations:

• The ACH subspecialties available are

• Community Paediatrics • ACH Emergency Department • Neonatology • ACH subspecialties

 Cardiology  Developmental / Adolescent Medicine  Endocrinology  Gastroenterology  Infectious Disease

• Outreach sites in Lethbridge, Medicine Hat, or Red Deer (inpatients, outpatients, emergency department, neonatology)

 Nephrology

• Peter Lougheed Hospital (inpatients, outpatients, emergency department, neonatology)

 Oncology

• Alberta Children’s Hospital (inpatients)

 Rheumatology

 Neurology

 Respiratory

Department of Paediatrics | Annual Report 2013

Post Graduate Medical Education

2012-13

2011-12

2010-11

PGME Programs and Trainees

89 trainees

There are three paediatric-affiliated PGME programs that being in the PGY1 year: • General Paediatrics

93 trainees

• Paediatric Neurology • Medical Genetics

117 trainees

(Note that Medical Genetics is a Section of the AHS Department of Paediatrics but is a Department in the Faculty of Medicine.) In addition, there are nine subspecialty paediatric programs that start at the PGY4 level or later: • Developmental Paediatrics • Emergency Medicine • Endocrinology and Metabolism • Gastroenterology • Hematology/Oncology • Infectious Diseases • Neonatology/Perinatology • Nephrology • Respiratory Medicine

Annual Report 2013 | Department of Paediatrics

General Paediatrics

Medical Genetics

Program Co-Directors: Dr. Deborah Fruitman & Dr. Kathy Tobler

Program Director: Dr. Mary Ann Thomas

Like all paediatric training programs in Canada, ours is of four years duration. The first three years cover core training in general paediatrics. The first year provides a breadth of exposure to general paediatrics.

The first two years of the program involve training in paediatrics, internal medicine, high risk obstetrics, and crisis counselling, with on-going communication with the Medical Genetics program director. The third year of the program is devoted to clinical metabolic service and laboratory experience with rotations in cytogenetics, molecular genetics and biochemical genetics. It is possible to begin some clinical genetics rotations in the third year and participation in genetics outreach clinics and resident clinic starts in this year.

The second year facilitates career options by exposing residents to subspecialties in greater depth. The third year is designed to consolidate the education acquired in core rotations and to provide opportunities for more elective rotations to deepen knowledge and experience in selected areas. The final year is flexible, with residents able to pursue subspecialty training, or spend more time training as a community or hospital based general paediatrician. Trainees: 2012/2013: 45

Attendance at clinical genetic reviews and weekly genetics seminars is recommended. A core month of genetics occurs each year for all residents (R1-R5). The clinical component during the 4th and 5th years of training is based at the Alberta Children's Hospital. There is an active consulting service in clinical genetics for both in-patients and out-patients through the Alberta Children's Hospital. In addition, there is an extensive outreach program with clinics in Lethbridge, Medicine Hat, and Red Deer. Trainees: 2013/2014: 5

Department of Paediatrics | Annual Report 2013

Neurology

Developmental Paediatrics

Program Director: Dr. Michael Esser

Program Director: Dr. Ben Gibbard

The Paediatric Neurology Program at the University of Calgary is education driven.

The University of Calgary offers a two-year training program in Developmental Paediatrics accredited by the Royal College of Physicians and Surgeons of Canada. The program is designed for 1-2 residents per year. The training program's goal is the development of trainees with excellent clinical skills in an atmosphere of academic inquiry.

During the first year of the program, Residents attend the weekly Paediatric Grand Rounds, and participate in other General Paediatric teaching rounds and Paediatric academic half day seminars one half day per week. During the first year, the Residents also take part in a 4-week Research Methods Course, which enables them to prepare a clinical or basic science research project to be completed within the next two to three years of their training.

Trainees:2012/2013: 1

Most of the 5-year Paediatric Neurology Residency Training Program is spent at the Alberta Children's Hospital with the exception of the rotations in Neonatal Intensive Care, which take place at the Foothills Medical Centre, and rotations in Adult Neurology, which occur at the Foothills Medical Centre, the Peter Lougheed Centre, the Rockyview General Hospital, and the newly constructed South Health Campus Hospital in Calgary. Trainees: 2012/2013: 9

Annual Report 2013 | Department of Paediatrics

Emergency Medicine

Endocrinology and Metabolism

Program Director: Dr. Izabela Sztukowski

Program Director: Dr. Jonathan Dawrant

The Paediatric Emergency Medicine Program is of two years duration. In the first year, there is an emphasis on significant exposure to the paediatric emergency department experience, as well as exposure to critical care and anaesthesia subspecialties for residents coming from both the Paediatric and Emergency Medicine tracks. Additional training ensures exposure to surgical and emergency subspecialties or paediatric subspecialties, depending on where the resident's core training was. There is also an emphasis on the initiation of research and this is carried through in both first and second years with dedicated blocks. The second year of fellowship continues to provide varied clinical experiences, as well as exposure to administrative and leadership responsibilities.

The Residency Program in Paediatric Endocrinology and Metabolism was established in November 2002. It is a two-year subspecialty post-graduate program located at the Alberta Childrenâ&#x20AC;&#x2122;s Hospital and University of Calgary Faculty of Medicine. Residents receive clinical and academic training in the principles of endocrine and metabolic disease as they apply to children and adolescents and acquire the knowledge and skills necessary to fulfill the essential roles and key competencies of an Endocrinologist as defined by the Royal College of Physicians and Surgeons of Canada. Usually only one or two Residents are enrolled in the program per year and accordingly, individualized teaching and training is provided by our faculty. Upon completion of the program, trainees are equipped to function as consultants in Paediatric Endocrinology either in an independent private practice or in an academic teaching or research program within a university setting.

In the junior year of fellowship, the resident would participate in the Paediatric or Emergency Medicine preparation program for the Royal College examination, i.e., OSCE, written examination, oral examination, and observation of clinical skills, to help ensure successful outcome in the core specialty.

Trainees: 2011/2012: 2

Trainees: 2012/2013: 7

Department of Paediatrics | Annual Report 2013

Gastroenterology Program Director: Dr. Leanna McKenzie

The Section of Paediatric Gastroenterology and Nutrition offers two types of subspecialty residency training: • A two-year fellowship for trainees wishing to develop clinical skills in paediatric clinical gastroenterology and nutrition; and • A three-year fellowship combined with Master’s degree or research project for those interested i n pursuing a career in academic paediatric gastroenterology and nutrition. The first year of training is primarily clinical, and residents spend approximately half the year on clinical inpatient service performing supervised consultations at the inpatient units and emergency department of Alberta Children’s Hospital. When not performing inpatient service, trainees participate in outpatient clinics, endoscopy, research, electives and education sessions. The second and third years are similar to the first, but with less inpatient service. Clinical electives are encouraged, and residents are encouraged to arrange electives in nutrition, hepatology (within Canada or international), and pathology. Electives in motility, metabolics, radiology,

Annual Report 2013 | Department of Paediatrics

and research may also be arranged. Trainees pursuing an academic career with a three year residency may enter a basic or clinical science research fellowship, or may pursue a Master’s degree in Clinical Epidemiology, Public Health or Medical Education, with a focus on Gastroenterology. Education time is protected, and residents participate and contribute to the weekly paediatric gastroenterology academic half-day as well as other scheduled teaching sessions. Residents are expected to submit a small research project in their first year, and develop a more substantial research project during their second and third year (if applicable). The ten faculty members at Alberta Children’s Hospital demonstrate a commitment to education and have a wide variety of clinical and research interests including Mucosal Immunology, Inflammatory Bowel Disease, Celiac disease, Hepatology, Intestinal Failure, Cystic Fibrosis, Medical Education and Motility. Trainees: 2012/2013: 4

Infectious DiseaseS

Neonatology

Program Director: Dr. Rupesh Chawla

Program Director: Dr. Majeeda Kamaluddeen

Training incorporates the principle of increasing responsibility. It includes one year of clinical residency in the entire spectrum of acute, chronic and recurrent infectious diseases in hospitalized and ambulatory patients, with opportunities to participate in epidemiologic studies of infections in the hospital and community. Two months of the one-year experience is spent in adult infectious diseases.

Neonatal/Perinatal Medicine residency program is a twoyear program with an optional third year for research. The curriculum includes a minimum of 12 months of clinical rotation. Six months of this is at the Level 3 NICU at Foothills Medical Centre, a tertiary care centre with high risk obstetric and perinatology services and, three months is at the Alberta Childrenâ&#x20AC;&#x2122;s Hospital NICU which provides care for surgical, cardiac and complex care neonates. Rotations in Level 2 nursery and paediatric critical care may be counted towards these 12 months. Participation in research is strongly recommended with time and mentorship allocated for research activity. Research pursuits of the mentors encompass clinical, epidemiological and medical education. Other academic activities include rotations in Maternal-Fetal Medicine, Perinatal follow-up clinic and, participation in academic half-day sessions, clinical rounds, grand rounds and journal club etc.

Trainees will receive six months of full time laboratory residency in medical microbiology including virology, bacteriology, mycology and parasitology. At least one of these six months is committed to virology. One month is spent in Infection Prevention and Control. Five months of approved residency in infectious diseases, or microbiology, or in research is offered, relevant to the goals of the trainee, the objectives of infectious diseases, and acceptable to the program director. Elective experiences outside of Calgary are possible. The Infectious Diseases clinical service at Alberta Childrenâ&#x20AC;&#x2122;s Hospital consists of daily ambulatory clinics and inpatient consultations. The program includes academic rounds with the paediatric infectious disease group as well as city-wide combined adult and paediatric infectious diseases. An academic half-day is organized for ID trainees in both the paediatric and adult programs with a two year cycle of seminar topics.

Trainees: 2012/2013: 12

Trainees: 2012/2013: 2 Department of Paediatrics | Annual Report 2013

Respiratory Medicine

Paediatric Nephrology

Program Director: Dr. Marielena DiBartolo

Program Director: Dr. Lorraine Hamiwka

We have a 2-year, RCPSC-accredited subspecialty residency program, which can be extended towards a research career or further clinical training if desired. There is space for 2 fellows per program year. Most of the core Pediatric Respiratory Medicine clinical work is accomplished in the first year, although there is an expectation that the primary research project will be developed and initiated during this time as well. The main focus of the second year of training is broadening of expertise through clinical electives, and completion of the scholarly project. There are components of the program that can be tailored to each individual interest.

The University of Calgary offers a two to three-year training program in Paediatric nephrology approved by the Royal College of Physicians and Surgeons of Canada. The program is designed for 1-2 trainees per year.

Rotations are on a 4 weekly basis (13/year). One month in Adult Respirology and 2 months in intensive care (PICU and/or NICU) are mandatory. Electives are chosen from disciplines relevant to Respiratory Medicine including Radiology, Otolaryngology, Infectious Disease, and Allergy/immunology. These months are planned according to the objectives of the fellow in conjunction with the respiratory residency training director and in collaboration with other associated programs. Trainees: 2012/2013: 3

During the first clinical year, the trainee will perform supervised inpatient, outpatient, and emergency department clinical consultations at the Alberta Children's Hospital. The trainee will develop skills in all aspects of chronic and acute care in paediatric nephrology including the management of general nephrology, chronic kidney disease, dialysis and transplant patients. Trainees participate in and contribute to the nephrology academic half day, literature reviews/journal clubs, and nephrology teaching rounds. The development of a research proposal will be initiated in the first year, the majority of which will be carried out during the second and/or third year of training. Three blocks are available for either research or elective time during the first year of training. During the second and third year, trainees continue to attend outpatient clinics and perform call duties. Up to eight months of research or elective rotations are available. Trainees intending to focus on a clinical paediatric nephrology residency will continue to enhance their clinical experience but at a more advanced and specialized level. Trainees pursuing an academic career may complete basic or clinical science research training including entering into a graduate program (M.Sc. or Ph.D) or a medical education fellowship, all with an emphasis on paediatric nephrology.

Annual Report 2013 | Department of Paediatrics

Trainees: 2012/2013: 3

Continuing Medical Education (CME)

Director: Dr. Julian Midgely

The Department conducts weekly Paediatric Grand Rounds from September to June of each academic year. These rounds are held in the Auditorium at ACH but are also broadcast via telehealth to other hospitals and offices throughout Calgary, Alberta and south-eastern British Columbia. The audience comes from all the disciplines involved in the care of children. Throughout the year, several special named rounds are held including the Dr. Donald Clogg Lecture in Paediatric Emergency Medicine and the Dr. Sam Darwish Lecture in Paediatric Neurology. Of the 40 Grand Rounds in 2013 speakers from outside ACH, including 8 from various cities in the US, presented on 15 occasions. Most sections conduct regular continuing education rounds, often in conjunction with adult specialty colleagues. These include evening rounds organized by Community Paediatricians often with speakers from ACH paediatric subspecialty sections.

The Department of Paediatrics contributes to various Faculty of Medicine CME courses including the Practical Pediatrics Course (held in June), the Evening Course Program for family physicians and the Calgary Therapeutics Course. In February 2013, the 22nd International Paediatric Infectious Diseases Course was held in Banff. Dr. Taj Jadavji founded and still directs this longstanding and successful course. In March 2012, the second “PEACH” (Pediatrics Emergencies ACH) conference was held at ACH. Dr. Angelo Mikrogianakis is the director of this exciting new course. In May 2013 the first “Paediatric Update Conference” for family physicians, paediatricians and other paediatric health care workers was held with good attendance and excellent reviews.

Department of Paediatrics | Annual Report 2013

HUMAN Simulation Education Program Director: Dr. Vincent Grant An internationally-recognized simulation-based education program is located at the ACH, with medical leadership through the Department of Paediatrics. The ACH KidSIM™ Program (www.kidsim.ca) provides hands-on learning in paediatric acute care to undergraduate and postgraduate learners, as well as to practicing healthcare professionals, with a focus on team training, interprofessional education and patient safety. Novel programs include a Family Centred Care initiative to use simulation to teach families via simulation, a mobile outreach program that provides interprofessional education to the rural and regional centres in Southern Alberta and South-eastern British Columbia, and a Just-in-time Education Program aimed at preparing care providers in real time for patients most likely to deteriorate during their care, among many others. The KidSIM™ Program has also developed a reputation for high quality faculty development through its’ leadership of the nationally-recognized WISE (Workshops In Simulation Education) curriculum and invitations to present faculty development workshops at both national and international meetings. The KidSIM™-ASPIRE (Assessing Simulation in Paediatrics:

Annual Report 2013 | Department of Paediatrics

Improving Resuscitation Education) Paediatric Research Program has become an emerging international leader in simulation-based research, with a significant number of competitive grants, publications, and abstracts accepted at national and international conferences. KidSIM™ Faculty Members are also in significant leadership roles in the Faculty of Medicine at the University of Calgary, the eSIM Provincial Simulation Program, the Canadian Paediatric Simulation Network, the Canadian Network for Simulation in Healthcare, the Society for Simulation in Healthcare and the International Paediatric Simulation Society. The program, currently in its’ 9th year of existence, held approximately 400 sessions (60% of which were interprofessional in nature) and taught 3,500 learners in 2012/13, adding up to almost 1,000 hours of simulationbased education. A total of 85 educators provide training using simulators from neonatal to adolescent mannequins. A new $2.4 million dollar simulation suite is officially opening in January 2014.

Children who rely on care from the Alberta Children’s Hospital PATIENT ORIGINS

NUMBER OF PATIENTS

Airdrie ......................................................................2,699 Banff ............................................................................. 121 Bragg Creek................................................................ 107 Brooks ......................................................................... 295 Calgary................................................................... 63,332 Canmore ..................................................................... 296 Carstairs ...................................................................... 200 Chestermere .............................................................. 940 Cochrane .................................................................1,164 Drumheller ................................................................. 176 Edmonton ................................................................... 151 Fort McMurray............................................................. 63 Grande Prairie ............................................................. 45 High River ................................................................... 453 Innisfail ......................................................................... 121 Irricana........................................................................... 68 Lethbridge ................................................................... 742 Medicine Hat .............................................................. 626 Morley.......................................................................... 339 Nanton .......................................................................... 98 Okotoks ...................................................................1,258 Olds .............................................................................. 239 Red Deer .................................................................... 612 Rocky Mountain House ........................................... 120 Siksika .......................................................................... 155 Strathmore ................................................................. 699 Sundre.......................................................................... 119 Other Alberta Locations ......................................5,566 ALBERTA TOTAL 80,804

C lih o rd n r ne ac at w er C oh orf dlih r er yl t m ’ne eh H s

tip

British Columbia........................................................ 732 Saskatchewan ............................................................. 374 Manitoba ....................................................................... 16 Ontario .......................................................................... 20 Quebec .............................................................................5 Atlantic Canada ..............................................................8 Canadian Territories ................................................... 26 TOTAL OTHER PROVINCES & TERRITORIES 1,181 OUTSIDE CANADA

*OVERALL PATIENT TOTAL

35 82,020

*represents the number of individual patients who visited the Alberta Children’s Hospital in 2011-2012

.... .... N .... . U .... .... BM P ..... ..... RE ITA ...... ...... ..... . . E . FO N ..... ..... ..... ST 6,2 ...... ...... ...... 99 ... ...... ...... 1 12 1 ... ....... ....... 70 2 .. 6 ... ... 59 3,3 ....... 23 2 .. ..... 69 2 .. 00 9 .. 04 46

DEPARTMENT OF PAEDIATRICS | ANNUAL REPORT 2013

special feature

Mentorship Program

A committee was struck in 2011 to design a mentorship program, and it was launched in Fall 2012 with its first intake of participants. The mentorship begins with coaching mentee participants to define a project that they are passionate about, is part of their usual job activities in one of the clinical, education, service or research domains, is achievable within the program time-frame and will result in a defined scholarly output.

Dr. Steven Martin – Mentor and Dr. Joseph Vayalumkal – Mentee

There are two components to the program: a structured curriculum and a formal mentee-mentor pairing to facilitate the project completion. The curriculum in 2012-2013 consisted of 8 monthly half-day sessions on a wide variety of topics presented by speakers both external and internal to the department. Mentees and mentors also met regularly throughout the program to ensure support and progress on the projects.

Communicating Infection Control Data Effectively - Are We Meeting the Needs of ACH Staff? A Quality Improvement Initiative Dr. Joseph Vayalumkal (Infectious Diseases) was paired with Dr. Steven Martin (Gastroenterology) for the inaugural Department of Pediatrics mentorship program. The team embarked on a quality improvement project related to effective communication of data. The project revolved around the recognition that Infection Prevention and Control programs generate data that can be useful to front-line healthcare workers. However, these data are usually not easily accessible and their format may not be considered user-friendly to most healthcare workers. The objective of this project was to survey healthcare workers about the types of data they would find useful and how it should be shared. The pair met regularly to plan and discuss the implementation of the project. Although there were a few delays in meeting proposed deadlines, the survey was successfully completed. In total, 418 ACH staff took part in the survey. The project is now in the data analysis stage. ACH staff can look forward to easier access to infection prevention and control data which should hopefully lead to improved staff engagement/education regarding infection prevention practice and ultimately safer care for patients.

Annual Report 2013 | Department of Paediatrics

The list of Mentees and Mentors last year and their subjects: Mentor

Mentee

Dr. Suzette Cooke Dr. Leonie Herx Developing & validating a set of entrustable professional activities for palliative medicine: Phase One in designing a summative postgraduate learner assessment Dr. Pam Veale Dr. Doan Le Mission Possible: Teaching students CanMEDS using missions sent from website or iPhone App Dr. Karen Barlow Dr. Rebecca Sparkes Development of a proposal & business case for a newborn metabolic screening follow-up clinic at ACH Dr. Karen Barlow Dr. Ellie Vyver Planning and development of a proposal for a new Sexual Health Clinic for ACH Dr. Doug Strother Dr. Adam Spencer Validation of sonographic assessment of gastric volume in the paediatric patient by gastroscopic examination Dr. Deb Dewey Dr. Tony Truong Predictive factors for Stem Cell Infusion Reactions in Paediatric Patients Undergoing Stem Cell Transplantation Dr. Steve Martin Dr. Joseph Vayalumkal Communicating Infection Control Data Effectively. Are We Meeting the Needs of ACH Staff?

Awards and Recognitions

Dr. Frank Dicke

Department of Paediatrics Academic Leadership Award

Department of Paediatrics Clinical/ Educator Award

Dr. Jong Rho

Dr. Suzette Cooke

CCPE (Canadian Certified Physician Executive)

Dr. Vince Grant University of Calgary, Faculty of Medicine Full Time Faculty McLeod Award for Distinguished Achievement in Education

Dr. Nicola Wright Top 40 Under 40 Avenue Magazine

Dr. Ian Mitchell Canadian Medical Association William Marsden Award in Medical Ethics

Department of Paediatrics Humanitarian Award Dr. Nalini Singhal

Department of Paediatrics Community Paediatrics Award

Dr. Roxanne Goldade University of Calgary, Faculty of Medicine Alumnus of Distinction Award

Dr. Jean-Francois Lemay University of Calgary, Faculty of Medicine Full Time Faculty Guenter Award for Distinguished Achievement in International Health

Dr. Thiru Govender Dr. Julian Midgley Queen Elizabeth II Diamond Jubilee Medal and Harold W. Ashenmil Award The Kidney Foundation of Canada

Dr. Albert Akieme Queen Elizabeth II Diamond Jubilee Medal

Dr. David Stephure The Alberta Childrenâ&#x20AC;&#x2122;s Hospital Medical Staff Association Annual Award of Excellence

Annual Report 2013 | Department of Paediatrics

UME Awards GENERAL Paediatrics PGME PROGRAM Teaching Awards Dr. Linda Bakovic Dr. George Prieur Paediatric Scholarship

Dr. Kathy Tobler

Dr. Anke Banks

Dr. Ian Mitchell

Dr. Husam Zaki (Sam) Darwish Clinical Teacher of the Year Award — S ubspecialty Paediatrics

Dr. Jonathan Darwant

Dr. Danièle Pacaud

Dr. Deborah Dewe

Dr. Doan Le

Dr. Jonathan Darwant

Dr. Lisa Lemieux

Dr. Marielena DiBartolo

Dr. Amonpreet Sandhu

Dr. Estee Grant

Dr. Kim Smyth

Dr. Husam Zaki (Sam) Darwish Clinical Teacher of the Year Award — Hospital Paediatrics

Dr. Josephine Ho

Dr. David Stephure

Dr. Nicole Johnson

Dr. Pamela Veale

Dr. Jason Silverman

Dr. Charlene Kennedy

Dr. Andrew Wade

Clinical Teacher of the Year Awarded to Subspecialty Fellows In Recognition of Outstanding and Dedicated

Dr. Leanna McKenzie

Teaching to the Paediatric Residents

Dr. Julian Midgley

Dr. Heidi Angeles Dr. Husam Zaki (Sam) Darwish Clinical Teacher of the Year Award —Community Paediatrics

Dr. Dominique Eustace

Associate Dean’s Letter of Excellence Award

Department of Paediatrics | Annual Report 2013

Letters of Excellence Awards

Gold Star Award

Bronze Star Awards

Staff Award

Dr. Lisa B. Lemieux

Dr. Essa Al-Awad

Dr. Hani Had

Dr. Mark Anselmo

Dr. Candice Bjornson

Dr. Marielena DiBartolo Dr. Estee Grant Dr. Doan Le Dr. Amonpreet Sandhu

Silver Star Awards Dr. Deborah Dewey Dr. Doan Le Dr. Lisa Lemieux

Gold Awards

Dr. Julian Midgley Dr. Andrew Wade

Dr. Jonathan Darwant Dr. Marielena DiBartolo Dr. Jennifer D’Mello Dr. Estee Grant Dr. Charlene Kennedy Dr. Doan Le Dr. Jean Mah Dr. Leanna McKenzie

Dr. Estee Grant

Dr. Ian Mitchell

Dr. Doan Le

Dr. Danièle Pacaude

Dr. Lisa Lemieux

Dr. Rebecca Perry

Dr. Marielena DiBartolo

Dr. Amonpreet Sandhu

Dr. Nicole Johnson

Dr. Kim Smyth Dr. David Stephure Dr. Pamela Veale

Annual Report 2013 | Department of Paediatrics

Teaching 80+ Hours Dr. Adam Kirton Dr. Lucie Lafay-Cousin Dr. Victor Lewis Dr. Jean Mah Dr. Julian Midgley Dr. Peter Nieman Dr. Cheri Nijssen-Jordan Dr. Izabela Sztukowski Dr. Graham Thompson Dr. Pamela Veale Dr. Christopher Waterhouse

The Department of Paediatrics Innovation Award

This year, the Department of Paediatrics introduced a new funding initiative to support an individual or group engaged in innovative projects related to provision of clinical care, education or research within the Department of Pediatrics.

Successful projects for 2012 • Dr. Susan Bannister and colleagues: “Strengthening Paediatric Undergraduate Education at the University of Calgary by Contributing to the National Undergraduate Paediatric Curriculum” (Education) • Dr. Stephen Freedman and colleagues: “Assessing Dehydration at Triage Employing End Tidal CO2 Monitoring in Children with Gastroenteritis” (Research) • Dr. Adam Kirton and colleagues: “Healthy Infants and Children Clinical Research Program (HICCUP)” (Research) • Dr. Antonia Stang and colleagues: “Traditional Research Nurses versus an Innovative Undergraduate Research Assistant Program: the Parent Perspective (the TRAIN study)” (Research)

Annual Report 2013 | Department of Paediatrics

• Dr. Graham Thompson and colleagues: “Heal Education and Literacy (Project HEAL); a Multi-Modal Educational Platform for Parents” (Education) • Dr. Alfred Yeung and colleagues: “The Effects of Cognitive Behavioural Therapy with Adjunctive Hypnotherapy on the Neurobiology of Adolescent Irritable Bowel Syndrome: A Pilot Study” (Clinical) • Dr. Doan Le, Mike Paget, Pamela Veale. Hematology/ Oncology Section Members: Mike Leaker, Nicola Wright, MacGregor Steele, Douglas Strother, Victor Lewis, Ronald Anderson, Lucie Lafay-Cousin, Tony Truong, Greg Guilcher: “The Mission Possible CanMEDS team”

special feature

Mission Possible App

Highlighted from this year’s recipients is Dr. Doan Le and colleagues who have collaborated on an App in an innovative way to engage preceptors to teach roles and medical trainees to learn them.

During the Paediatric Hematology/Oncology Elective, agents will: • Complete each and every Mission safely • Review each and every Mission with a Preceptor

The Mission Possible CanMEDS team Doan Le, Mike Paget, Pamela Veale. Hematology/Oncology Section Members: Mike Leaker, Nicola Wright, MacGregor Steele, Douglas Strother, Victor Lewis, Ronald Anderson, Lucie Lafay-Cousin, Tony Truong, Greg Guilcher Background It is the expectation from the Royal College that trainees be taught and evaluated based on all CanMEDS roles: Medical Expert, Communicator, Collaborator, Manager, Health Advocate, Professional, and Scholar. Explicit teaching of all CanMEDS roles during a clinical rotation can be challenging. Methods Trainees are tasked with completing “missions” based on CanMEDS roles and then review with preceptors.

• Claim prize • Initial pilot of the Missions on paper based format during student electives • Collect feedback from faculty and trainees • Develop an app for portability and ease of use “in the moment” Mission Samples • Medical Expert: Observe bone marrow aspirate • Communicator: Take a history on how chronic disease has a effected child’s life • Collaborator: Meet the members of multidisciplinary team • Professional: Reflect back on a circumstance that caused you distress or you felt unprepared to handle including what you would do differently or who can help next time

Department of Paediatrics | Annual Report 2013

• SCHOLAR: Describe a case in which the management plan was unclear and how you would look in the literature

The CanMEDS app was presented as a poster at ICRE (International Residency Conference); this is an image element from the poster.

• HEALTH ADVOCATE: List how you could advocate for resources for a patient seen in the clinic • MANAGER: How would you plan your day if you have two consults in the ward, one in ER, a drop-in clinic patient, and presentation Results A total of 7 trainees (clerks or residents) were included in the pilot project. Trainees completed 4-7 missions during their rotation and made the following comments: • “Refl ection is especially important for diffi cult cases. Good to debrief with others.” • “Online access might make it easier to remember.” • “I really enjoyed the missions because it forced me to push myself to look for opportunities to practice or watch others practice these roles.” • “Emphasized CanMeds Roles that we don’t always get teaching on.” • “Staff enthusiastic to engage in the “Missions.”

ANNUAL REPORT 2013 | DEPARTMENT OF PAEDIATRICS

The Future Mission Possible can be used by other sections within the Alberta Children’s Hospital to connect with one another and to engage multiple trainees simultaneously. In development is a website and iPhone App that would permit Missions to be distributed. The website or App will also be capable of tracking CanMEDS teaching in a variety of rotations. For more information on the Innovation Award Program or the CanMEDS app visit this address link. http://www.ucalgary.ca/paed/Special_Feature-CanMEDS_App

Department of Paediatrics | Annual Report 2013

New Department Faculty Members

Annual Report 2013 | Department of Paediatrics

Dr. Susanne Benseler Section of Rheumatology

Dr. Natalie Forbes Section of Community Paediatrics

r. Ping Wei Chen D Section of Emergency Medicine

Dr. Cara Gilman Section of Community Paediatrics

Dr. Seen Chung Section of Emergency Medicine

r. Leonora Hendson D Section of Neonatology

Dr. Kristin Evashuk Section of Community Paediatrics

r. Russell Lam D Section of Emergency Medicine

100

Dr. Linda Loovere Section of Community Paediatrics

r. Aleksandra Mineyko D Section of Neurology

r. Nadia Luca D Section of Rheumatology

r. Jane Ng D Section of Community Paediatrics

r. Paola Luca D Section of Endocrinology

r. Laine Racher D Section of Community Paediatrics

r. Ayman Abou Mehrem D Section of Neonatology

r. Swati Rastogi D Section of Community Paediatrics

Department of Paediatrics | Annual Report 2013

Dr. Lioba Redel Section of Community Paediatrics

r. Sumesh Thomas D Section of Neonatology

r. Lauren Redgate D Section of Community Paediatrics

r. Erika Vorhies D Section of Cardiology

r. Naminder Sandhu D Section of Emergency Medicine

r. Theresa Wu D Section of Hospital Paediatrics

r. Amelie Stritzke D Section of Section of Neonatology

r. Desiree Yow D Section of Community Paediatrics

Annual Report 2013 | Department of Paediatrics

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Research Funding

External Peer-Reviewed Research Grants

* Existing funding in 2012-13 ** New funding in 2012-13 All grant funding data shown below is based on submissions from Department of Paediatrics members. Grant funding obtained after June 30, 2013 is not included in this report.

1. *2011-13 Impact of simulation-based skill acquisition instruction (SSAI) on competence in performing effective manual mask ventilation (MMV) in a randomized group of Neonatal Resuscitation Program (NRP) providers Amount: (Total): $ 25,000.00 Sponsor: Neonatal Resuscitation Program, Canadian Paediatric Society Role: Primary Investigator Harish Amin 2. *2012-2014 An Internet-based Psychoeducational Game for Children with Juvenile Idiopathic Arthritis (JIA) and their Parents: A Randomized Controlled Trial Amount: $692,988 Source: Canadian Institutes of Health Research Role: Co-Applicants Stinson J, Benseler S, Berard R, Campillo S, Dancey P, Duffy C, Feldman B, Huber A, Johnson N, Luca N, McGrath P, Shiff N, Spiegel L, Tse S, Tucker L, Victor C.

Annual Report 2013 | Department of Paediatrics

3. **2012-2017 Chronic Childhood Vasculitis: Characterizing The Individual Rare Diseases To Improve Patient Outcome. Amount: $2,500,000 Source: Canadian Institutes of Health Role: Co-Primary Investigator Benseler SM. Co Investigators: Cabral D, Foell D, Hancock R, Ross C. 4. **2010-2015 Team in Linking Exercise, Physical Activity and Pathophysiology in Childhood Arthritis a Canadian Collaborative Team (LEAP) Amount: $3,500,000 Source: C anadian Institutes of Health Research Role: Local Co-Investigator Benseler SM. Co Investigators: C. Duffy, L. Tucker, R. Yeung, H. Mackay, A Baxter-Jones 5. *2012-2014 Canadian Malnutrition Task Force Amount: $40,050

Source: Funding through Canadian Nutrition Society Role: Primary Investigator: Dr. Dana Boctor 6. *2012-2013 Development of a Patient Education Prototype in Intestinal Failure NAPSGHAN I Amount: $2,000 Source: In-Office Member Grant for Development of Patient Education Prototypes Primary Investigator: Dr. Dana Boctor 7. *2010-2013 AHSI can Village health volunteers trained in integrated case management of childhood illness improve access to care for Africa’s most valuable children Funding (Total): $ 350,000.00 Sponsor: Canadian International Development Agency Primary-Investigator: Jen Brenner, Co Investigator N Singhal

8. *2012-2013 Prognosticators of persistent concussion symptoms following paediatric minor traumatic head injury Amount: $17,700 Source: The Canadian Institutes of Health Research Role: Primary Investigator: R. Zemek RL , Freedman SB (Co-Investigators), Osmond M, Vassilyadi M. 9. *2012-2013 Management of Acute Gastroenteritis: Synthesizing Evidence to Inform North American Practice Amount: $100,000 Source: The Canadian Institutes of Health Research (CIHR; funding reference #: 119808) Role: Primary Investigator: R. Freedman SB Co-Primary investigators, Hartling L, Johnson D, Gouin S, Black K, Fitzpatrick E, Bialy L, Klassen T, Belanger F, Hilliard B, Jabbour M. 10. *2012-2013 Abdominal X-Ray Use and

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the Misdiagnosis Rate in Children with Constipation. Amount: $7,298 Source: The Hospital for Sick Children, Paediatric Emergency Medicine, Research Fund Role: Primary Investigator: R. Freedman SB, ThullFreedman J, Manson D, Schuh S, Rumantir M. 11. *2011-2015 Translating Emergency Knowledge for Kids (TREKK) Amount: $1,200,000 Source: Networks of Centres of Excellence (NCE) Program - Knowledge Mobilization Role: Co-Investigators: R. Klassen T, Hartling L, Jabbour M, Johnson D, Scott S, Sinclair D, Lang E, Freedman SB, Black B, Gouin S, Stang A. 12. *2011-2013 Children with Acute Gastroenteritis: Predictors of increased length of stay in the emergency department Amount: $2,000 Source: IWK Health Centre Role: Primary-Investigator: R Schindler N, Freedman SB (Co-SRA), Black, K 13. *2011-2013 Population Based Cohort to Determine Effect of ED Paediatric Gastroenteritis Strategies on Admission and Return Visit Rates Amount: $20,000 Source: Physicians Services Incorporated

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Role: Primary-Investigator: R Bahm A, CO-SRA: Freedman SB, Co-SRA: Guttmann A 14. *2011-2013 Inhaled Magnesium in Refractory Paediatric Acute Asthma Amount: $500,920 Source: Thrasher Research Fund Role: Primary Investigator: R Schuh S, Co- Investigator Freedman SB, CoInvestigator Ducharme F, Co- Investigator Black K, Co- Investigator Johnson D, Co- Investigator Beer D, Co- Investigator Plint A, Co- Investigator Zemek R, Co- Investigator Guimont C, Co-Investigator Willan A, Co-Investigator Thompson G, Co-Investigator Coates A 15. *2010-2012 Isotonic versus hypotonic IV maintenance fluids in children: a randomized controlled trial Amount: $46,742 Source: Physicians' Services Incorporated Role: CoInvestigator R Geary D, Co- Primary Investigator, Co-Investigator Freedman SB, Co-Investigator Beck C, Co-Primary-Investigator Freidman JN 16. *2010-2012 Electrolyte Maintenance Solution Administration Required in LowRisk Children with Gastroenteritis?

Amount: $169,200 Source: Physicians' Services Incorporated Role: Primary- Investigator: R. Freedman SB, Co- Investigator Boutis K, Co- Investigator Parkin P, Co-Investigator Goia C, Co- Investigator Atchison D, Co-Investigator Schuh S 17. *2012-2014 Ondansetron Use in Children with Dehydration in a Developing Country Amount: $100,000 Source: Bill and Melinda Gates Foundation Grand Challenges Explorations Grant Role: Primary Investigator: R. Freedman SB, Bhutta Z. 18. **2013-2018 Ondansetron administration to children with gastroenteritis associated vomiting in EDs in Pakistan Amount: $446,956 Source: Thrasher Research Foundation Role: Freedman SB (PI), Willan A, Razzak J, Siddiqui E, Bhutta Z. 19. *2010-07 to 2013-07 Perioperative Ischemic Evaluation-2 (POISE-2) Amount: $7,800,000 Total: $3,600,000.00 Source: Canadian Institutes of Health Research Role: Site Investigator (University of Saskatchewan): Gamble J

20. *2012-05 to 2012-08. Endotracheal Tube Palpation To Assess Endotracheal Depth In Paediatric Patients Amount Total: $4,250.00 Source: Deans Summer Research Project College of Medicine - University of Saskatchewan. Role: Principal Investigator: Gamble J 21. *2008-2013 Early Life Experience and Child Development at 8 Years. Source: Calgary Children’s Imitative Amount: $40,000.00 (January 1, 2008 - December 31, 2013) Co-Investigators Gibbard WB 22. *2008- 2013 Developmental Coordination Disorder: From Genes to Behaviour Amount: $1,135,866.00 Source: Canadian Institutes of Health Research Role: Co-Investigators Lemay J-F; Collaborator: Gibbard WB 23. *2010-2012 Little Movements - Lots To Learn: Validation Of A Parent Questionnaire To Screen For Developmental Coordination Disorder In Preschool Children Amount: $40,000.00 Source: Alberta Centre for Child, Family and Community Research Role: Co-Investigator: Gibbard WB

24. *2010-2013 Can Adherence to PALS Guidelines be Improved by Team Training of Paediatric Resuscitation Team Members? Amount: $474 000 Source: Funding obtained from Heart and Stroke Foundation of Canada and Canadian Institutes of Health Research, 3 years, Principal-Investigator: Gilfoyle, E 25. *2012 Canadian Hospital Injury Reporting and Prevention Program Source (CHIRPP) Amount: $398,077.87 Source: Public Health Agency of Canada Primary Investigator: Dr. Jonathan Guilfoyle 26. *2010-2014 Assessing and Improving the Quality of Cardiopulmonary Resuscitation (CPR) Delivered During Simulated Paediatric Cardiac Arrest using a Novel CPR Feedback Device Amount: $450,000 CAD Source: Heart and Stroke Foundation of Canada and Canadian Institutes of Health Research Role: Primary Investigators: Dr. Vincent Grant, A Cheng Alberta Children’s Hospital, Dr. Jonathan Duff, Stollery Chldren’s Hospital, Dr. Farhan Bhanji, Dr. Ronald Gottesman, Montreal Children’s Hospital, Dr. Vinay

Department of Paediatrics | Annual Report 2013

Nadkarni, Children’s Hospital of Philadelphia and Dr. Betsy Hunt, Johns Hopkins Children’s Hospital and the EXPRESS Investigators. 27. *1994-2013 Adverse Event Study, Laboratory of Diseases Control Amount: $10,0000 Source: Canadian Pediatric Society, IMPACT (Immunization Monitoring Program, Active) Role: Local-PrimaryInvestigator T Jadavji 28. *2009-2014 Stemming the epidemic of liver related morbidity and mortality in HIV-HCV coinfection: Is ART enough? Amount: $1,924,155.00 Source: Canadian Institutes for Health Research Role: Co-Investigator T Jadavji 29. *2011-2014 The Implementation and Evaluation of an Alberta Childhood Asthma Clinical Pathway Amount: $149,980.00 Source: AIHS Primary Investigator: Dr. David Johnson Co-Investigator G Currie, Co-Investigator A NettelAguirre, Co-Investigator S Spier 30. *2011-2014 Combined Glucocorticoid Adrenergic Therapy

Amount: $150,000.00 Source: Husky Energy Chair in Child & Maternal Health Primary-Investigator: Dr. David Johnson 31. *2012-2016 The Alberta Perinatal Stroke Project Amount: $750,000, Direct (during 2012-2013): $20,000 Source: Alberta Innovates Health Solutions Collaborative Research and Innovation Opportunities Project Role: Primary Investigator: Kirton A; Co-leads: Yager J, Andersen J, Collaborators: Brooks B, Dukelow S, Kosior J, Hagel B, Buchhalter J, Nettel-Aguirre A, O’Grady K, Hill MD. 32. *2011-2014 Pathophysiology of Perinatal Stroke Amount Total: $150,000 Source: NeuroDev Net Role: Principal Investigator A Kirton, Co-Investigator K Yusuf 33. *2008-2015 Natural History Study Of The Development Of Type 1 Diabetes; Sub-Study: Oral Insulin For Prevention Of Diabetes In Relatives At Risk For Type 1 Diabetes Mellitus Source: NIH, NIDDK Role: Site PrimaryInvestigators C Huang, Co-Investigator D Pacaud, Co-Investigator D Stephure, Co-Investigator J Ho

Annual Report 2013 | Department of Paediatrics

34. **2013-2016 Enhanced Care for Rare Genetic Diseases in Canada Amount: $11,853,890 Source: Genome Canada Role: Co-Applicant: M Innes 35. *2009-2014 Vascular effects of infection in paediatric stroke (VIPS) Amount: Direct (during 2012-2013): $18,000 Source: NIH Co-Investigators: A Kirton, Primary Investigator: H Fullerton, University of California at San Francisco 36. *2011-2015 Thrombolysis in paediatric stroke (TIPS) A safety study of tPA in acute childhood stroke Amount: Direct (during 2012-2013): $11,000 Source: NIH Role: Co-Investigator A Kirton, Primary Investigator: G deVeber, University of Toronto 37. *2011-2013 Diffusion tensor imaging of corticospinal tract integrity in perinatal stroke Amount: Direct (during 2012-2013): $10,000 Total: $40,000 Source: Canadian Institutes of Health Research Training Program in Genetics, Child Health, and Development. Graduate studentship (Ms. Jacquie Hodge) Primary-Investigator: A Kirton

38. *2011-2013 Expansion of a Canadian Multi-Regional PopulationBased Cerebral Palsy Registry Amount: Direct (during 2012-2013): $20,000 Source: Public Health Agency of Canada Co-Investigators: A Kirton, M Shevell McGill University Z 39. *2010-2013 Pathophysiology of perinatal stroke Amount: Direct (during 2012-2013): $36,000 Total: $150,000 Source: NeuroDevNet Role: Principal Investigator A Kirton, Co-Principal Investigator A NettelAguirre 40. *2006/06-Present AML Risk of Infection Study Amount: $1,700 Source: Hospital for Sick Children, Toronto, ON Local Primary-Investigator: Lewis, V 41. *2009-2013 Corneal Confocal Microscopy to detect Diabetic Neuropathy in Children Amount: Direct (during 2012-13): $45,000 Source: Juvenile Diabetes Research Foundation Total: $362,358 Co-Investigators: JK Mah, Daniele Pacaud

42. *2009-2014 Phase 2 Study on the Clinical-Demographic, Epidemiology, Pathobiology, Neuroimaging Features And Outcome Of Acute Demyelination In Canadian Children Amount: Total: $460,000, Direct (during 2012-13): $125,000 Source: US FSH Society and Muscular Dystrophy Canada Local Primary Investigator: J K Mah, Primary Investigator: B Banwell , Hospital for Sick Children 43. *2009-2017 Longitudinal Study of the Relationship between Impairment, Activity, Limitation, Participation and Quality of Life in Persons with Confirmed Duchenne Muscular Dystrophy Amount: Direct (during 2012-13): $25,000 Total: $125,000 Source: US Department of Defense and Cooperative International Neuromuscular Research Group Primary Investigator: JK Mah Site, C MacDonald, University of California at Davis 44. *2011-2014 A Multicenter Collaborative Study on the , Expression Profiling, and Quality of Life in Paediatric Fascioscapulchumeral Muscular Dystrophy Amount: Direct (during

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2012-13): $ 65,000 Total: $96,669 Source: US FSH Society and Muscular Dystrophy Canada Local Primary Investigator: JK Mah 45. *2011-2016 Duchenne Muscular Dystrophy: Double –blinded, Randomized Trial to find Optimum Steroid Regimen Amount: Direct (during 2012-13): $2,500 Total: $50,000 Source US NIH Site Primary Investigator: JK Mah, R Griggs CoPrimary Investigators University of Rochester and Kate Busby, Newcastle upon Tyne 46. *2011-2012 Partners with Schools (COMPASS) – A Collaborative Mental Health Services Model Source: Funded by Canadian Institutes of Health Research Amount: $15,000.00 (September 1, 2011 - August 31, 2012) Co-Investigators: McLennan J 47. *2006-2014 Steroid-associated Osteoporosis in the Paediatric Population Details: This is a multisite study, run from Ottawa with Dr Leanne Ward as the Principal investigator. It is CIHR funded for 5 years. I am a principal

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site collaborator for Rheumatology Amount: Total Award Nationally: $3,733,300.00— with portion to ACH Source: Canadian Institutes of Health Research Role: Site collaborator for Rheumatology PM Miettunen 48. *2008-12 AHFMR Interdisciplinary Team Grant in Vaccine Design and Implementation Amount: $5,000,000.00 Source: Alberta Heritage Foundation for Medical Research Interdisciplinary Team Grant Competition. Role: Co-Investigator JD Kellner, Collaborator OG Vanderkooi 49. *2009-2014 Evaluation of Meningococcal C Conjugate Vaccine Programs in Canadian Children Amount: $699,655.00 Source: Canadian Institutes of Health Research Institute of Population and Public Health Operating Grant Role: Co-Investigator JD Kellner, Co- Investigator OG Vanderkooi 50. *2010-2015 Canadian Microbiome Initiative Amount: $2,484,542.00 Source: Canadian Institutes Of Health Research Emerging Team Grant Canadian Institutes for

Health Research. Role: Co- Investigator JD Kellner 51. *2009-2012 PHAC/ Canadian Institutes of Health Research Influenza Research Network Amount: $10,800,000.00 Source: Canadian Institutes of Health Research Institute of Infection and Immunity & Public Health Agency of Canada. Role: Co-Investigator: S Kuhn, Co- Investigator O Vanderkooi Co-Investigator JD Kellner 52. *2008-present Hospital for Sick Children, Toronto, On Weekly Vinblastine for Chemotherapy Native Children with Progressive Low Grade Glioma Amount: $1,230 Role: Co-Investigators: Lafay-Cousin L, Narendran A 53. *2011-13 Metformin in women with type 2 diabetes in pregnancy trial Amount: (Total): $1.78 million Source: Canadian Institutes of Health Research Role: Local-Co-Investigator A Lodha, Site Primary Investigator L Donovan Primary Investigator: Denice S. Feig, University of Toronto

54. **2012 MiTy Kids: Metformin in Women with Type 2 Diabetes in Pregnancy Kids Trial Amount: $650 per patient) -2012 Source: Canadian Institutes of Health Role: Principal Investigator: Feig, D. (University of Toronto) Site collaborator: J Ho 55. *2010-2014 Metabolic Mechanisms of Functional Neuroprotection in Epileptic Brain Amount: Direct (during 2012-2013):$56,500 Total $300,000 Source: NINDS, NIH Co-Primary-Investigators: JM Rho, DY Kim Barrow Neurological Institute, Phoenix, Arizona 56. *2006-12 Efficacy and safety of targeting lower arterial oxygen saturations to reduce oxygen toxicity and oxidative stress in very preterm infants: Canadian Oxygen Trial Amount: $3,691,500 Source: Canadian Institutes of Health Research Role: Schmidt, B.K., Roberts, R.S., Whyte, R.K., Asztalos, E.V., Shah, P., Solimano, A.J., Bairam, A., Seshia, M., Moddeman, D.M., Chiu, A., Roukema, H.W., Sauve, R.S., Rabi, Y., Harrold, J.E., Clarke, M.C.W., Kumar, M., Peliowski

57. *2008-13 CIHR Team in MaternalInfant Care – Translating knowledge into improved care Amount (Total): $4,902,135.00 Source: Canadian Institutes Of Health Research Role: SitePrimary Investigator R Sauve, Project Lead) Primary Investigator: S. Lee, University of Toronto 58. *2010-15 CAP 11 years outcomes Amount (Total): $407,627.00 Source: Canadian Institutes Of Health Research Role: Site Primary Investigator R Sauve, Primary Investigator: B Schmidt, McMaster University 59. *2009-14 Alberta Sepsis Network Amount: $5,000,000.00 Sponsor: AHFMR Role: Co-Investigator R Sauve, Primary Investigator P Kubes, Site Lead Thomson GC (Team Members): Gilfoyle, E and Blackwood, J 60. *2011 – 2014 The Canadian Kidney Knowledge Translation and Generation Network (CANN-NET) Amount: $543,542 Source: Canadian Institutes of Health Research

Department of Paediatrics | Annual Report 2013

Co-Investigator– S Samuel, Principal Investigator: B Manns 61. *2011 – 2014 A Health Services Research Program for Paediatric Nephrology Amount: $50,000 (Infrastructure amount with matching funds from the Department of Pediatrics) Source: Kidney Foundation of Canada/ Canadian Institutes of Health Research /Canadian Society of Nephrology Role: Primary Investigator: S Samuel 62. *04/2010-03/2013 Pharmacogenetics of juvenile idiopathic arthritis – A genome wide association study on the efficacy and toxicity of methotrexate therapy Amount: $240,000 Source: Canadian Arthritis Network Role: Principal-Investigator H Schmeling, Co-Investigator P Miettunen 63. *2008-2013 Impact of (ACoRN) Acute Care of at Risk Newborn Education Program in Rural China Amount (Total): $180,000.00 Source: China joint Canadian Institutes of Health Research Role: Primary Investigator N Singhal

64. *2008-2014 The Impact of Maternal Nutrient Status during Pregnancy on Maternal Mental Health and Child Development Funding (Total): $4,999,998.00 Sponsor: AFHMR Role: Co-Investigator N Singhal

Freedman SB, Co-Investigator Stang A

Association Role: Primary Investigator K Yusuf

68. *2011-2013 Different Corticosteroid Dosing Strategies At Discharge For Acute Asthma Primary Amount: $5,000.00 Source: CAEP Investigator: Dr. Antonia Stang

72. *2011-2014 Pathophysiology of Perinatal Stroke Amount Total: $150,000 Sponsor: NeuroDev Net Role: Primary Investigator A Kirton, Co-Investigator K Yusuf

65. *2013 Charting the Territory – Determining and Documenting Trajectories For Families Where A Child Has a Life-threatening Condition Amount: funded for $23,000 per year, ending in 2013 Source: Canadian Institutes Of Health Research Role: Site Principal Investigator: Sharron Spicer

69. *2011-2014 A randomized control trial to evaluate the efficacy of a social skills intervention group for childhood survivors of brain tumours Amount: $44,164 Source: Canadian Cancer Society Research Institute Co-Investigator: Barrera M, Strother D

73. *2011-2013 Umbilical cord blood levels of angiogenic and anti-angiogenic factors and risk of retinopathy of prematurity Amount: (Total): $20, 259 Source: The Lions Sight Center Fund Role: Primary Investigator K Yusuf

66. *2011-2021 Quality Indicators of ED Overcrowding Amount: $18,000.00 Source: NSERC Primary Investigator: Dr. Antonia Stang

70. *2010 Evaluating Processes of Care & the Outcomes of Children in Hospital (EPOCH) Amount: $3,266,764. Source: Grant awarded by Canadian Institutes Of Health Research, 4 years, Site Investigator Tobler, K

74. **2013-14 Paediatric Procedural Skills – Re-evaluating the Competencies Co-Investigator H Amin Amount Total: $ 4,085.00 Source: Paediatric Consultants Education Grants, University of Toronto

71. *2011–2013 Umbilical cord blood levels of angiogenic and antiangiogenic factors and risk of bronchopulmonary dysplasia in preterm neonates Amount: (Total): $25,000 Source: Angela Jone Memorial Clinical Research Award – The Lung

75. **2012-2017 Predicting Persistent Postconcussive Problems in Pediatrics (5P) Amount: $1,273,705 Source: The Canadian Institute for Health Research (CIHR) Role: Primary Investigators: Zemek R, Osmond M, Anderson P, Barlow K,

67. *2011-2015 Translating Emergency Knowledge for Kids TREKK Amount: $86,801.89 Source: University of Manitoba Role: Principal-Investigator: Dr. Antonia Stang Co-Director Johnson D, Co-Investigator Currie G, Co-Investigator

Annual Report 2013 | Department of Paediatrics

Barrowman N, Boutis K, DeMatteo C, Farion K, Freedman SB, Gagnon I, Gravel J, Hoshizaki B, Keightley M, Klassen T, Meeuwisse W, Meehan W, Mikrogianakis A, Vassilyadi M, Johnson D, Plint A 76. ** 2013 –2018 Post-concussion syndrome affecting Youth: GABAergic effects of melatonin Amount: $875,392 Source: Canadian Institutes of Health Research Role: Primary Investigator Barlow, KM, Co-Primary Investigator Dewey, D. Co-Investigators: Brooks, B., Crawford, S., Esser, M., Johnson, D.W., Kirk, V., Kirton, A. MacMaster F, Mikrogianakis, A. Nettel A 77. ** Development of a uniform histology scoring systems for Small Vessel CNS Vasculitis in adulthood and childhood. Amount: $40,128.10 US Source: Vasculitis foundation. Role: Primary Investigator: Benseler SM, Twilt M, Hawkins C. 78. **2012-2015 An internet-based psychoeducational program for children with juvenile idiopathic arthritis (JIA) and their parents: A randomized controlled trial Amount: $614,303

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Source: Canadian Institutes of Health Research Role: Co-Investigator. Benseler SM. Principal Investigator: Stinson J. Collaborators: Campillo S, Duffy C, Feldman B, Hetherington R, Huber A, McGrath P, Palermo T, Spiegel L, Tse S, Tucker L, Victor C, Shiff N, Johnson N, Dancy P, Berard R. 79. ** 2012-2013 Towards developing MR imaging guidelines and outcome measures in juvenile idiopathic arthritis: a special interest pediatric research group. Amount: $24,954 Source: Canadian Institutes of Health Research (CIHR). Role: Co-Primary Investigator Benseler SM, Principal Investigator: Doria A. Collaborators: Van Rossum M, Miller E, Rosenberg A, Roth J, Stinson J, Tse S, Yeung R. 80. **2012â&#x20AC;&#x201C;2013 Diagnostic accuracy of peripheral quantitative computed tomography (pQCT) in pediatric osteoporosis Amount: $199,000 CAD. Source: Canadian Institutes of Health Research (CIHR). Role: Principal Investigators: Doria AS, Cheung A, Gordon C, Beyene J. Co-I. Benseler SM CoInvestigators: Feldman B, Laxer R, Silverman E,

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Yeung R, Harvey E, Paresh R, Tomlinson C, Sochett E, Howard A, Sung L, Stinson J, Furlan A, Grynpas M, Gahunia H. 81. **2012 What matters the most for parents, patients and clinicians in predicting the course of juvenile idiopathic arthritis? Amount: $54,366 Source: Canadian Initiative for Outcomes in Rheumatology Care Awareness/Advocacy/ Education Grant. Role: Co-Primary Investigator: Benseler SM. Co-Investigators: Guzman J, Berard R, Duffy C, Jurencak R, Oen K), Petty R, Shiff N, Tucker L. 82. **2009-2014 Linking Exercise, Physical Activity and pathophysiology in Juvenile Arthritis Source: A Canadian Collaborative Team grant CHIR funded grant Amount: $2,448,419 Role: Local Investigator: Benseler S, Principal Investigator: Duffy C, Ottawa 83. **2013-2016 Treatment of cholesteroldependent pulmonary surfactant dysfunction Amount total: $700,000 over 3 years 2013: $233,333

Source: Alberta Innovates Health Solutions Role: Collaborating scientist Bjornson, C Primary Investigator: M. Amrein 84. **2012-2013 The Evolution of a Pulmonary Exacerbation: A Preliminary Analysis of Bacterial Population Dynamics Culminating in Acute Respiratory Perturbations Amount: Recruitment phase. $30,000 Source: Cystic Fibrosis Canada Role: Primary Investigator: M. Parkins, Co-investigator C. Bjornson 85. **2013-2016 Learning and reinforcement in adolescents with Autism Spectrum Disorders Source: SickKids Foundation Amount: New Investigator Award, 2013-2016, Amount: $100k/annum, Role: Primary Investigator: Signe Bray

improvements in rural Uganda through a new Institute for Maternal, Newborn and Child Health Amount: $28 250 Source: CIDA/University Partnerships in Cooperation and Development Program Role: Primary Investigator Jennifer Brenner 88. **2012 - 2014 Healthy Child Uganda (HCU); Scaling up comprehensive MNCH Programming to create a model District in Bushenyi, Uganda Amount Total: $4,666,574.00 Source: Canadian Institutes of Health Research Role: Primary Investigators Jen Brenner Co-Investigator N Singhal

86. **2013 Structure-function relationships in healthy brain development Amount: 2017, $29k/annum Source: NSERC Discovery Grant, 2013 Role: Primary Investigator: Signe Bray

89. **2013-Present Canadian Children Inflammatory Bowel Disease Network: A Joint Partnership of CIHR and CH.I.L.D. Foundation $5,000,000.00 Source: Foundation for Children with Intestinal and Liver Disorders (CH.I.L.D.) and the CIHR Institute of Nutrition, Metabolism and Diabetes (INMD) Co-applicant, site director: Dr. Jennifer deBruyn

87. **2013 Sustaining child health

90. **2012-2013 General Operating Grant

Amount: $8083.00 Source: IDRU Primary Investigator: JD Butzner 91. **2009-2014 EXPRESS Paediatric Simulation Research Amount: $450,000 USD Source: Laerdal Foundation for Acute Medicine, Infrastructure Grant Role: A. Cheng, With: Dr. Elizabeth Hunt, Division of Critical Care Medicine, Johns Hopkins University and Dr. Vinay Nadkarni, Division of Critical Care Medicine, Childrenâ&#x20AC;&#x2122;s Hospital of Philadelphia 92. **2012 Research Fellowship Amount: $45 000 Source: Royal College of Physicians and Surgeons of Canada Role: Primary Investigator: Suzette Cooke 93. **2013-2018 Mild Traumatic Brain Injury in Children and Youth: Best Practices in Early Diagnosis and Treatment Amount: Amount: $2,148,468 Source: Canadian Institutes of Health Research & Hotchkiss Brain Institute Team Grant Role: Principal Investigator: Emery CA Co-investigators: Meeuwisse WH, Dukelow S, Debert C, Brooks B,

Department of Paediatrics | Annual Report 2013

Shneider K, Benson B, McKay C, Kang J, Barlow K, Babul S, Macpherson A, Hagel BE, Iverson GL, Scott Iry CA 94. ** 2012-2013 Improving Patient Safety During Anesthesia: Inserting the Catheter Directly into the Lumbar Space Amount Total: $6,245.00 for 2012 to 2013-06-28 Source: Research Trust Fund Role: Primary Investigator: Gamble J 95. **2013-2015 A Prospective Randomized Double Blinded Control Trial using Ketamine or Propofol for Electroconvulsive Therapy: Improving Treatment-Resistant Depression Amount: Total: $25,000.00 for 2013-09-02 to 2015-12-31 Source: Schulman Medical Research Fund Foundation Amount Total: $25,000.00 for 2013-03 to 2015-03 Source: Royal University Hospital Role: Primary Investigator Gamble J 96. **2012 An Assessment of Prevalence and Clinical Care of Type 2 Diabetes in Albertan Children Amount: $50,000 Source: Women & Children’s Health Research Institute Role: Primary Investigator Toth, E. (University of

Alberta) Co-investigators: Ho, J. and Jetha, M. 97. **2012 Cerebral diaschisis in neonatal arterial ischemic stroke Amount Total: $7000, Direct (during 2012-2013): $7000 Source: Canadian Stroke Network Role: Primary Investigator: A Kirton 98. **2012 Impact of perinatal stroke on parents and families Amount Total: $12,000, Direct (during 2012-2013): $12,000 Source: AIHS and HBI Role: Primary Investigator: A Kirton

101. **2012-2014 Understanding the neurophysiology of paediatric migraine with TMS Amount Total: $136,000, Direct (during 2012-2013): $68,000 Source: CIHR Training Program in Genetics, Child Health, and Development. Clinical Research Fellowship (Dr. Thilinie Rajapakse) Primary Investigator: A Kirton, Co-Investigator K Barlow

99. **2012 Quantification of gliosis in perinatal stroke and relationship to outcome Source: Alberta InnovatesHealth Solutions Amount Total: $5200, Direct (during 2012-2013): $5200 Role: Primary Investigator: A Kirton

102. **2012-2015 Enhancement of developmental motor plasticity in perinatal stroke with Transcranial Direct Current Stimulation Amount Total: $270,000, Direct (during 2012-2013): $90,000 Source: Heart and Stroke Foundation Role: Primary Investigator: A Kirton, Co-Investigator: D Dewey

100. **2012 Time course of cerebral diaschisis in childhood arterial ischemic stroke Amount Total: $5200, Direct (during 2012-2013): $5200 Source: AIHS Role: Primary Investigator: A Kirton

103. **2013 Cerebrovascular complications of bacterial meningitis in children Total: $5200, Direct (during 2012-2013): $5200 Source: Alberta InnovatesHealth Solutions Role: Primary Investigator: A Kirton

Annual Report 2013 | Department of Paediatrics

104. **2013 Resting state fMRI motor network analysis in perinatal stroke Role: Primary Investigator: A Kirton Source: NSERC Create IT3 Graduate Studentship Direct (during 2012-2013): $12,000 Total $12,000. 105. **2013-2015 Robotic assessment of proprioceptive dysfunction in children with perinatal stroke Role: Primary Investigator: A Kirton Source: Cerebral Palsy International Research Foundation Direct (during 2012-2013): $50,000 Total: $100,000 106. **2013 BDNF genetics of neuroplasticity in cerebral palsy Source: Robertson Fund for Cerebral Palsy, Hotchkiss Brain Institute Amount: 1 year, $30000 CDN (July 2013 – June 2014) Role: Primary Investigator: Kirton A, Hill M 107. *2012 International Maternal Newborn Stroke Registry Amount: 2 years, $40000 Source: World Federation of Neurology Role: Primary Investigators:

Bushnell C, deVeber G, Kirton A 108. **2013 GeoSentinel Surveillance program Amount: $6600 estimate based on enrolment projections Source: PHAC provided a grant to the CDC/ISTM Role: Local Primary Investigator S Kuhn 109. **2013-2014 Travellers Who Visit Friends and Relatives and Their Acceptance of Specific Preventive Measures Substudy. Amount: $1,200.00 Source: Substudy of PHAC Grant Role: Local Primary Investigator S Kuhn 110. **2013-2014 Travellers Who Visit Friends and Relatives and Their Acceptance of Specific Preventive Measures Amount: $10,000.00 Source: PHAC Role: Local Primary Investigator S Kuhn 111. **2012-2013 Programme Intégré de formation clinique chirurgicale de base (CCB) aux étudiants de médecine en stage de chirurgie de la FSSA pour répondre aux besoins sanitaires haïtiens de première ligne. Amount: $24,750.00

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Source: CBIE Govt Canada Role: Primary Investigator Lemay J-F 112. **2012-2013 Programme Intégré de formation neurologique de base pour les étudiants de médecine de la FSSA afin de répondre aux besoins sanitaires haïtiens de première ligne. Amount: $24,780.00 Source: CBIE Govt Canada Role: Primary Investigator Lemay J-F 113. **2012-2013 Education médicale pour les professeurs d’Haïti: nouvelle approche Source: CBIE Govt Canada Amount: $24,650.00 Role: Primary Investigator Lemay J-F 114. **2012-14 Seminal Canadian Recommendations for Evidence–Based Examination of Neonates for Retinopathy of Prematurity (SCREEN– ROP) Study Amount Total: $455,000.000 Source: Canadian Institutes of Health Research Role: Site Primary investigator: A Lodha, Site Co investigator: A Ells Primary Investigators: Kourosh Sabri, McMaster University

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115. **2012-13 Caring for late preterm infants: public health nurses’ and Parents’ experiences Premji Amount Total: $40,000.00 Source: Alberta Centre for Child, Family and Community Research Role: Co Investigators: A Lodha, Shahirose 116. **2012-17 Enhancing Breast Milk Production Domperidone in Mothers of Preterm Neonates (EMPOWER Study) Amount Total: $999,454.00 Source: CIHR Role: Site Primary investigator: A Lodha, Co Investigator: J Boulton Primary Investigators: Elizabeth Asztalos, University of Toronto 117. **2014-2015 Trends in Oxygen Saturation in Healthy Term Infants in the First Few Days of Life: The “TOST” study Amount: $10,000 Source: Sandra Schmirler Foundation Grant Role: Loganathan P, Al Awad E, Fajardo C, Lefebvre C, Lodha A, Nair V, Nettel-Aguirre, Ratslaf K, Wainer S, Young M, Rabi Y

118. **2012-2013 Validation of The Standardized Universal Pain Evaluations For Rheumatology Providers For Children And Youth (Super-Kidz) Amount: $49,992 Source : Canadian Arthritis Network, Discovery Advancement Program Role: Principal Investigator: Stinson J Co-Investigators: Luca N, Feldman B, Benseler S, Bayoumi A, Beaton D, Campillo S, Leblanc C

Team (APPETITE): Moving into the Future Epidemiology, Emerging Organisms, and Economics Amount: $24,783 Source: Alberta Innovates – Health Solutions Role: Primary Investigators Freedman SB, Chuck A, Lee B, Johnson D, Currie G, Talbot J, Jiang J, Dickinson J, Kellner J, MacDonald J, Svenson L, Chui L, Louie M, Lavoie M, Eltorki M, Vanderkooi O, Tarr P, Tellier R, Ali S, Drews S, Graham T, Pang X.

119. **2013–2018 Alberta Program in Youth Sport and Recreational Injury Prevention Amount: $2,425,000 Source: Alberta Innovates Health Solutions Collaborative Research and Innovation Program Role: Collaborative Co-Leads: Emery CA, Hagel BE Collaborative Members: Meeuwisse WH, McCormack G, Rowe BH, Nettel-Aguirre A, Voaklander D, Finch C, Verhagen E, Macpherson A, Groff P, Goulet C, Kang J, McKay C, Richmond SA, Schneider K, Russell K, Doyle-Baker PK, Babul S, Marshall D, Currie GR, Ferber R.

121. **2013-2018 Magnesium Nebulization in Management of Paediatric Asthma – MagNUM PA Trial Amount: $2,137,058 Source: The Canadian Institute for Health Research Role: Primary Investigator: Schuh S, CoInvestigators: Freedman SB, Zemek R, Plint A, Johnson D, Thompson G, Ducharme F, Gravel J, Klassen T, Curtis S, Beer D, Black K, Coates A, Willan A.

120. **2013 Collaborative Team - Letter of Intent, Alberta Provincial Paediatric EnTeric Infection

122. **2013-2014 Prenatal Cigarette Smoke Exposure and Neonatal Control Amount: PER YEAR: $30,000 Source: The Lung Association, Alberta and NW Territories Role: Primary Investigator SU Hasan

123. **2013-2014 Infant Car Safety Seats and Cardiorespiratory Events in Preterm Infants Amount: PER YEAR: $30,000 Source: The Lung Association, Alberta and NW Territories Role: Primary Investigator SU Hasan 124. **2013-2014 Virtual Peer-to-Peer (VP2P) Support Mentoring for Adolescents with Juvenile Idiopathic Arthritis: A Feasibility Pilot Randomized Controlled Trial Amount: $99,987 Source: Canadian Institutes of Health Research Role: Principal Investigators: Stinson J & Bell M, Co-investigators: Ahola Kohut S, Junkin L, Spiegel L, Amaria K, Kaufman M, Victor J, Cooper D, Luca N, Forgeron P, Marcinko 125. ** 2013-2016 Paediatric obesity program evaluation Amount: $300, 000 Source: BMO Research Prize in Healthy Living Role: Principal Investigator: Reimer, R. Co-investigators: Elliott, C., MacMaster, F., Ho, J., Jelinski, S., Edwards, A. 126. **2013 The Canadian Neuromuscular Disease

Department of Paediatrics | Annual Report 2013

Registry Amount Total: $30,000, Direct (during 20122013):$6000 Role: Primary local Investigator: JK Mah, Primary Investigator L Korngut 127. **2013-2014 STEADFAST: A pilot randomized clinical trial on Stacking Exercises Attenuate the Decline in Forced Vital Capacity and Sick Time. Amount: $30,000, Direct (during 2012-13): $3000 Source: Children’s Hospital of Eastern Ontario Role: Site Primary Investigator: JK Mah, Primary Investigator: Sheeri Katz 128. **2013-2017 Ontario Child Health Study Sequel. Amount: $5,312,446.00 Source: Canadian Institutes of Health Research Role: Co-Investigator McLennan J 129. **2012-2013 Ontario Child Health Study Sequel preparation grant Amount: $100,000.00 Source: Canadian Institutes of Health Research Role: Co-Investigator McLennan J 130. **2012-2013 Suicide Prevention in Canada Youth: Options and

Evidence. Amount: $100,000.00 Source: Canadian Institutes of Health Research Role: Co-Investigator McLennan J 131. **2012-2013 Improving the mental health of Canadian children and adolescents: A research synthesis Amount: $100,000.00 Source: Canadian Institutes of Health Research Knowledge Synthesis Grant Role: Co-Investigator McLennan J 132. **2012-2013 Canadian Pediatric Society’s Surveillance Program on Periodic Fevers Amount: $ 5000 Source: Canadian Pediatric Society Role: Principal investigator Paul Dancey, Co-investigators Marco Gattorno, Anne Junker, Ronald Laxer, Paivi Miettunen 133. **2012-2017 Neurodevelopment of preschoolers exposed perinatally to bisphenol A and phthalates: Interactions with diet and neurotoxicant co-exposures. Amount: $1,271,880 Source: Canadian Institutes of Health Research Role: Primary Investigator Martin JW, CoInvestigators: Dewey D,

Annual Report 2013 | Department of Paediatrics

Dinu I, Field C, Giesbrecht GF, Kaplan B, Kinniburgh D, Letourneau L., Yasui Y 134. **2012-2013 Clinical Trials Support Amount: $1,823.19 (USD) Source: 2NCI (US), Children’s Oncology Group Chair Grant Primary Site Investigator: Strother, D 135. **2013-present Children’s Oncology Group, Chair Amount: $11,100 Source: NIH / COG Role: Lafay-Cousin, L 136. **2012-2020 POETIC A Phase I Study Using Plerixafor as a Chemosensitizing agent for Relapsed Acute Leukemia and MDS in Pediatric Patients Amount: $4,074.80 Role: Primary Investigator Narendran, A 137. **2012-2017 Modulation of BrainSpecific ATP-Sensitive Potassium Channels by Physiological Stereoisomers of the Primary Ketone Body BetaHydroxybutyrate Amount Total: $712,613, Direct (during 2012-2013): $109,832 Source: Canadian Institutes for Health Research Role: Primary Investigator: JM Rho

138. **2013 – 2018 Canadian National Transplant Research Program: Increasing Donation and Improving Transplantation Outcomes Amount: $14,270,000 Source: Canadian Institutes of Health Research Role: Co-Applicant– Susan Samuel 139. **2012-13 Optimizing Outcomes of Children who Require Live-saving Complex Interventions Amount Total: $10,000.00 Source: Alberta InnovatesHealth Solutions Role: Site Primary investigator: R Sauve PI: CMT Robertson, University of Alberta 140. **2013 Preclinical validation and optimization of the ketogenic diet in the treatment of infantile spasms. Amount Total: $5000, Direct (during 2012-13): $5000 Source: University of Alberta studentshipPatricia Baccus Role: Primary Investigator: MH Scantlebury 141. **2013 Preclinical validation and optimization of the ketogenic diet in the treatment of infantile spasms.

Amount: Total: $7250, Direct (during 201213):$7250 Source: Branch Out Neurological FoundationPatricia Baccus Role: Primary Investigator: MH Scantlebury 142. **2012 - 2014 Identification of Barriers and Facilitators for Education of Nurses in Care of Sick and At-Risk Newborn Babies in India Amount Total: $ 16,000.00 Source: Indo-Canadian Shashtri Institute and WHO Role: Co Investigator N Singhal 143. **2013 - 2014 Beta Testing of Helping Babies Survive Program Amount Total: $20,000.00 Source: American Academy of Pediatrics/ Laerdal Foundation Role: Co Investigator: N Singhal **2012-14 A family integrated care model for neonatal intensive care units Amount Total: $349,982.00 Source: Canadian Institute of Health Role: Co Investigator: A Soraisham Primary Investigator: S Lee, University of Toronto

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INternal Research Grants

* Existing funding in 2012-13 ** New funding in 2012-13 ll grant funding data A shown below is based on submissions from Department of Paediatrics members. Grant funding obtained after June 30, 2013 is not included in this report.

1. *2011–2013 Oxidant And Anti-Oxidant Levels In Preterm Infants Before And After A Blood Transfusion Amount (Total): $43,554 Source: Alberta Children’s Hospital Research Institute Role: Co-Investigator: Albert Akierman, Richard Krause 2. *2011-2015 Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis on Daycare Attendance: Randomized Controlled Trial and Economic Analysis. Amount: $46,673 Source: Alberta Children’s Hospital Foundation Role: Co- PrimaryInvestigator Johnson D, Co- Investigator Sherman P, Co-Investigator Willan A, Co-Investigator Mittmann N, Co- Investigator Schuh S, Co-Primary- Investigator Freedman SB 3. *2012 Simulation for Family Centered Care: Improving Caregiver Skills, SelfEfficacy and Quality of Life using a Practice-UntilPerfect Intervention for Seizure Management in the Home Environment Amount: $91,337 Source: Alberta Children’s Hospital Foundation 4. Role: Site Investigator with:

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Primary Investigator Dr. Vincent Grant, Dr. Elaine Sigalet, Dr. Tyrone Donnon, University of Calgary. 5. *2009-2012 Can Umbilical Cord Blood Levels Of Angiogenic Factors And Endothelial Progenitor Cells (Epcs) Predict Risk Of Bronchopulmonary Dysplasia In Preterm Neonates? Amount (Total): $9958 Source: 2008 CLS (Calgary Laboratory Services) Health Services Research Funding Competition Role: Co-Investigator: Noureddine Berka and Faisal Khan, Immunogenetics and Histocomapatibility Lab, Calgary Laboratory 6. *2010-2013 A Study Of Endothelial Progenitor Cells And Factors Affecting Their Levels In Pregnant Women Who Smoke And Preeclampsia Amount (Total): $30,000 Source: Alberta Children’s Hospital Research Institute Role: Co-Investigator: Sue Ross, Noureddine Berka, Faisal Khan 7. *2011-2015 Non-HLA Immunogenetic Biomarkers Important for Pathogenesis and Therapy of Complications of Paediatric Hematopoietic

Cell Transplantation Amount: $19,440 Source: Alberta Children’s Hospital Foundation, Childhood Cancer Collaborative Role: Co-Investigator: Khan F, Lewis, V 8. *2009-2013 Transcranial Magnetic Stimulation: Study and treatment of Childhood Neurological disorders Amount: $500,000 Direct (during 2012-2013): $100,000 Source: Alberta Children’s Hospital Foundation Role: Principal-Investigator A Kirton 9. *2011-2014 Biological Markers of Perinatal Stroke Amount (Total): $50,000 Source: ACHRI/Alberta Children’s Hospital Foundation Role: Primary Investigator A Kirton, Co-Investigator K Yusuf 10. *2011-2013 Clinical Review and Cost Evaluation of a Paediatric Home Parenteral Therapy Program Amount: $25,000.00 Source: Department of Paediatrics Emerging Needs Fund 11. Role: Principal-Investigator: S Kuhn (Co-PrincipalInvestigator)

12. *2011-2013 Immunity and History to Routine Childhood Vaccinations in Children with Inflammatory Bowel Disease Amount: $49,026.00 Source: Alberta Children's Hospital Foundation Role: Co- PrimaryInvestigator S Kuhn, Co- PrimaryInvestigator J DeBruyn 13. *2011-2014 Biological Markers Of Paediatric Cerebrovascular Inflammation And Stroke Amount: $36,095 Source: Alberta’s Children’s Hospital Research Institute Principal Investigator: Kirton A. Collaborators: Mineyko A. DeVeber G, Narendran A, Schmeling H. Collaborator. Benseler SM 14. *2006-13 Long-Term Outcomes Of Infants With Chronic Lung Disease Amount: (total) $ 20,000.00 Source: Alberta Children’s Hospital Foundation Role: PRINCIPALINVESTIGATOR: A Lodha, Co-Investigator: R Sauve 15. *2011-13 Meta Analysis: Metformin Exposure and Immediate Neonatal Outcomes Amount: (Total): $ 3,000.00 Source: Alberta Children’s Hospital Research Institute Role: Principal-Investigator: A Lodha

Department of Paediatrics | Annual Report 2013

16. *2011-13 Overcoming Surfactant Inhabitation In Neonates And Infants – A Clinical Prospective Cohort Study With An Animal Model Correlate Role: Principal-Investigator: A Lodha Amount: $49,200.00 Source: Alberta Children’s Hospital Research Institute 17. *2012-2013 Peak Serum Bilirubin As An Indicator Of Hypoxic Ischemic Amount: $3000 Source: Alberta Children’s Hospital Research Institute Investigators: Loganathan P, Al Awad E, Fajardo C, Lefebvre C, Lodha A, Nair V, Nettel-Aguirre, Ratslaf K, Wainer S, Young M, Rabi Y

Concussion Symptoms? A Pilot Study To Refine A Clinical Prediction Rule, The 4C Tool Amount: $47,780 Source: Alberta Children’s Hospital Research Institute Co-Primary Investigator: A Mikrogianakis, Co Primary-Investigator K Barlow 20. ** 2012 –2013 Determining the Effect of a Targeted Video on Satisfaction with Transition from Paediatric to Adult Endocrine Care for Patients with Type 1 Diabetes Mellitus Amount: $2,199.00 Funding source: Alberta Children’s Hospital Research Institute Role: Principal Investigator D Pacaud, Co-Investigator J Ho, K Winston

18. *2009-2013 Paediatric Neurology Residents and Faculty Professional Development Grant Amount: Direct (during 2012-13): $15,600 Total: $60,000 Source: University of Calgary Local sub-Investigator: JK Mah

21. *2011 – 2014 Screening for Markers of Kidney Disease among Aboriginal Children and Youth: A Pilot Project Amount: $18,800 Source: University of Calgary, Petro Canada Community Innovator Award Role: Co-Investigator: S Samuel

19. *2011-12 Can We Foresee Which Children Will Have A Favourable Recovery Following A Mild Traumatic Brain Injury And Which Will Go On To Have Post-

22. *06/2009-03/2013 Pharmacogenetics of Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis – The Influence Of Polymorphisms In Genes Of Enzymes

Annual Report 2013 | Department of Paediatrics

Involved In Metabolism On The Efficacy And Toxicity Of Methotrexate Source: Alberta Children’s Hospital Research Institute Amount: $45,217 Role: Primary Investigator H Schmeling, Co-Investigator P Miettunen, Co-Investigator N Johnson 23. *2009-2012 Effect of Fluid Boluses on Cardiac Output and Heart Rate Variability in Newborns. A prospective Observational Study Amount (Total): $16,240.00 Source: Alberta Children's Hospital Foundation Role: Co-Investigator: N Singhal 24. *2011-13 Impact Of Central Line Bundle (A Quality Improvement Initiative) On The Incidence Of Central Line Associated Blood Stream Infection (CLA-BSI) In The Neonates Admitted To Neonatal Intensive Care Unit (NICU) Amount: (Total): $3,000.00 Source: Alberta Children’s Hospital Research Institute Role: Principal-Investigator: A Soraisham 25. *2011-2021 Quality Indicators of ED Overcrowding Amount: $15,000.00

Source: AHS Role: Principal-Investigator Dr. Antonia Stang 26. *2012-13 Establishing N-Telepeptide Reference Ranges in Health Children in Calgary Amount: $44 000 Source: Alberta Children’s Hospital Research Institute Role: Principal-Investigator Cristina Stoian 27. *2011-2012 Appendicitis in the Canadian Paediatric Population: An Analysis Using National Administrative Data Amount: $3,000.00 Source: Alberta Children’s Hospital Research Institute Principal-Investigator: Dr. Graham Thompson

Calgary Role: Physician mentor: Dr. J. Vayalumkal 30. *2012 IBD Research Support Amount Balance: ($5,484.55) Source: Department of Paediatrics Role: Principal-Investigator: Dr. Iwona Wrobel 31. *2011-2013 Can Changes In Pulmonary Function After A Loading Dose Of Caffeine Predict Extubation Outcome In Preterm Infants? Amount (Total): $3000 Source: Alberta Children’s Hospital Research Institute Role: Primary Investigator: K Yusuf

28. *2010-2013 Immunity and History to Routine Childhood Vaccinations in Children with Inflammatory Bowel Disease. Amount: $49,026.00 Source: Alberta Children’s Hospital Research Institute Role: Co-Investigator: OG Vanderkooi

32. **2012 – 2014 The Canadian Childhood Nephrotic Syndrome Project Amount: $20,000 Source: University of Calgary – Non-competitive funding Role: Principal Applicant: Roy Vi Baay Chair for Kidney Research

29. *2012 AMA's Emerging Leaders in Health Promotion grant provided to Jonathan Seto, Medical Student, University of Calgary Amount: $1000.00 Source: University of

33. **2012 Strengthening Paediatric Undergraduate Education at The University Of Calgary By Contributing To The National Undergraduate Paediatric Curriculum. Amount: $25 000

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Source: Department of Paediatrics Innovation Award, University of Calgary Role: Co-applicants: Primary Investigator - Susan Bannister, David Topps, Nicole Johnson, Glenda Bendiak, Julian Midgley 34. **2012-13 The Use Of Computerized Cognitive Testing In The ED To Predict Recovery Following A Mild Traumatic Brain Injury? A Study To Refine A Clinical Prediction Rule, The 4C Tool Amount: $43,500 Source: Alberta Children’s Hospital Foundation Role: Co-Principal-Investigator K Barlow 35. **2012-14 Optical Imaging in PostConcussion Syndrome In Children Amount: $63,500 Source: Alberta Children’s Hospital Foundation Role: Co-PrincipalInvestigator K Barlow 36. **2012-14 Novel Neuroimaging Strategies To Detect Biomarkers Of Recovery Following Treatment With Melatonin In PostConcussion Syndrome Amount: $33,500 Source: University of Calgary (U of C) Role: Principal-Investigator K Barlow

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37. **2012-14 Paediatric Brain Injury Catalyst Grant Amount: $100,000 Source: Alberta Children’s Hospital Foundation Role: Principal-Investigator K Barlow 38. **2013 Learning And Reinforcement in Adolescents with Autism Spectrum Disorders Amount: $18k Source: University of Calgary, University Research Grants Committee (URGC) seed grant Role: Principal-Investigator Signe Bray 39. **2012 In support of Serologic Protection to Routine Vaccinations in Children with Inflammatory Bowel Disease Amount: $10,000.00 Source: Alberta Children’s Hospital Department of Paediatrics Emerging Needs Fund Role: Principal-Investigator: JC DeBruyn 40. **2012 – Present An Evaluation of the Role of Paediatric Transient Elastography in Assessing Cystic Fibrosis Associated Liver Disease in Children with Cystic Fibrosis. Amount: $3,000 Source: Alberta Children’s Hospital Research Institute Small Research Grant

Role: Principal-Investigator: JC DeBruyn; CoInvestigators: Simon Lam, Helen Machida, Robert Myers, Clara Ortiz, S Martin. 41. **2012/2013 Assessing Dehydration at Triage Employing End Tidal CO2 Monitoring in Children with Gastroenteritis Source: Department of Paediatrics Innovation Award, University of Calgary Amount: $24,925 Co-Investigators: Dr. Stephen Freedman, David Johnson, Angelo Mikrogianakis 42. **2012-2013 Neurodevelopment Of Children Perinatally Exposed To Environmental Neurotoxicants: A Pilot Project In Support Of A CIHR Proposal. Amount: $3,000 Source: small grants competition, Alberta Children’s Hospital Research Institute Role: PRINCIPALINVESTIGATOR: Giesbrecht G, Co-Investigators: Dewey D, Martin J, Letourneau N, Kaplan BJ. 43. **June 2013 – June 2013 Psychological Distress and Cortisol Among Pregnant Women With Inflammatory Bowel Disease Amount: $17,883 Source: University of

Calgary Role: PI: Giesbrecht, G.F., Seow, C & Leung, Y 44. **2011-2014 Combined Glucocorticoid Andrenergic Therapy (Conjugate) Team Amount: $150,000.00 Source: U of C/AHS New Emerging Team grant Role: Principal-Investigators: D Johnson, A Stang 45. **2013-2014 HICCUP: Healthy infants and Children Clinical Research Program Amount: $25,000 Source: Dept of Paediatrics Innovation Award, Direct (during 2012-2013): $12,000 Role: Principal-Investigator: Kirton A; CI: Johnson D, Herpinger L, Denys J 46. **2012 – June 2013 Is Salivary Useful In Predicting Serum Cortisol for The Diagnosis Of Adrenal Insufficiency In Preterm Neonates Of 32 Weeks Of Gestation Or Less Amount: $49, 981.00 Source: Alberta Children’s Hospital Foundation Role: Principal-Investigator: D Pacaud, Co-Investigator H Amin 47. **10/2012-09/2014 Novel Diagnostic Approaches in Childhood Granulomatosis With

Polyangiitis Source: $20,000 Source: ACH Foundation/ Dawson Jarock Award Role: Principal-Investigator Co-Investigator: Marvin Fritzler, Susan Samuel, Paivi Miettunen, Aurora Fifi-Mah 48. **2012 Traditional Research Nurses versus an Innovative Undergraduate Research Assistant Program: the Parent Perspective (the TRAIN study) Amount: $24,662 Source: Department of Paediatrics Innovation Award, University of Calgary Role: Principal-Investigator R. Stang A, Thompson G, Johnson D, Freedman SB, Mikrogianakis A, Williamson J. 49. **2012 Teaching CanMEDS Roles Using Mission Impossible In Paediatric Hematology/ Oncology. Amount: $5470.00 Source: Department Of Paediatrics Innovation Award, University of Calgary Principal-Investigator: Veale PM 50. **Multimedia Educational Platform In The Paediatric Emergency Department Amount: $44,894.00 Source: ACHF

Department of Paediatrics | Annual Report 2013

Role: Principal-Investigator: Dr. Graham Thompson 51. **Chronic Abdominal Pain of Childhood: Evaluation in the Emergency Department Amount: $3,000.00 Source: Alberta Children’s Hospital Research Institute Role: Principal Investigator: Dr. Graham Thompson 52. **2011-Ongoing Test Characteristics of The Alvarado Score, The Paediatric Appendicitis Score And The Lintula Score Based Amount: $3,000.00 Source: Alberta Children’s Hospital Research Institute Role: Principal Investigator: Dr. Graham Thompson

Syndrome: A Pilot Study Amount: $25,000 Source: Department of Paediatrics Innovation Award Role: Alfred Yeung, Kathleen Schwartzenberger, Frank McMaster, Adam Kirton 55. *2009–2013 Profile Of Cytokines And Angiogenic Factors In Preeclampsia And Pregnant Women Who Smoke Amount: (Total): $45,000 Sponsor: Calgary Health Region (CHR) perinatal funding competition Role: Primary-Investigator: K Yusuf, Co-Investigator: Majeeda Kamaluddeen

53. **2013-2015 Hematological profile of appropriate for gestational age infants born to mothers with early onset preeclampsia Amount (Total): $2985 Source: Alberta Children’s Hospital Foundation, Alberta Children’s Hospital Research Institute. Co-Investigators: Mountasser Al-Mouqdad, Adnan Mansoor

56. **2012- 2013 Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome – A retrospective Cohort Study Using High Resolution Peripheral Quantitative Computed Tomography Amount: $12,481 Source: Alberta Children’s Hospital Research Institute Role: Primary Investigator D Stephure, Co-Investigator D Pacaud

54. **2012 The Effects of Cognitive Behavioural Therapy with Adjunctive Hypnotherapy on the Neurobiology of Adolescent Irritable Bowel

57. **2013-2015 Umbilical Cord Blood Levels Of Cortisol and Hemodynamic Status On Day 1 In Preterm Infants < 31 Weeks Gestation: A

Annual Report 2013 | Department of Paediatrics

Prospective Observational Study Amount (Total): $3000 Source: Alberta Children’s Hospital Research Institute Role: Co -Investigator: Saranya Manickaraj

**2013-2015 Neonatal Outcomes in preterm infants less than 34 weeks gestation born to preeclamptic mothers who smoke Amount (Total): $2962 Source: Alberta Children’s Hospital Research Institute. Co -Investigator: Vrinda Nair

Other external Research Grants

1. *2010-2014 Inhaled Nitric Oxide for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants Requiring Mechanical Ventilation or Positive Pressure Support on Day 5-14 after Birth Amount: Received todate (November 2013), $997,435.04 Currently (November 2013) available: $525,052.94 Excluding encumbrances: $435,382.10 Source: INO Therapeutics/ Ikari Role: Site PrincipalInvestigator SU Hasan 2. *2012-2013 Use of trio-based whole exome sequencing to identify the causes of sporadic syndromic intellectural disability: a pilot study with implications for the investigation for de novo Paediatric Disease Amount: $49,384.00 Source: Role: Principal Investigator M Innes 3. *2010-2013 CASPER-PCV (Calgary Area Streptococcus pneumoniae Epidemiology Research – Pneumococcal Conjugate Vaccine) Study: Continuation of Evaluation of Trends in Nasopharyngeal Colonization in Canada. Amount: $123,736.00 Source: Wyeth Pharmaceuticals (Grant-

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in-aid) Role: Primary Investigator JD Kellner, Co-Investigator O Vanderkooi *2011-2013 CASPER-PCV (Calgary Area Streptococcus pneumoniae Epidemiology ResearchPneumococcal Conjugate Vaccine) Study IV – Continuation of Surveillance and Analysis of Invasive Pneumococcal Disease (IPD) and Pneumococcal Related Disease (PRD) in Canada Amount: $649.146.00 Source: Pfizer Pharmaceuticals (Investigator Initiated Research) Role: Primary Investigator JD Kellner, Co-Investigator O Vanderkooi 4. *2011-2013 The Importance of International Travel in the Spread of ExtendedSpectrum beta-Lactamase Producing E.Coli Amount: $75,000.00 Source: Merck Canada (Grant in Aid) Role: Co-Investigators O Vanderkooi, S Kuhn 5. *2010-2015 PITT0908: Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies Amount Direct (during 201213): $4,500 Total: $25,000 Source: US Department of Defense and

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Cooperative International Neuromuscular Research Group Role: Local Primary Investigator JK Mah, Site Primary Investigator P Clemens, University of Pittsburgh 6. *2010-2012 An open-label study to assess the safety, tolerability and efficacy of canakinumab (ACZ885) in patients aged 4 years or older diagnosed with cryopyrin-associated periodic syndromes in Canada Amount: $13,299 Source: Novartis Role: Site Primary Investigator P Miettunen, Co Investigators H Schmeling, N Johnson 7. *2010-2012 A randomized, doubleblind, placebo controlled, withdrawal study of flare prevention of canakinumab (ACZ885) in patients with Systemic Juvenile Idiopathic Arthritis (SJIA) and active systemic manifestations Award: $ 6,310.00 Source: NovartisDetails: Protocol #CACZ885G2301 Role: Site Principal Investigator P Miettunen, Co-Investigators: H Schmeling, N Johnson 8. *2010-2012 An Open-Label Extension Study Of Canakinumab (ACZ885) In Patients With

Systemic Juvenile Idiopathic Arthritis (SJIA) And Active Systemic Manifestations. Amount total award: $4,450.00 Source: Novartis Details: Protocol # CACZ885G2301E1 Role: Site Principal Investigator P Miettunen, Co-Investigators: H Schmeling, N Johnson 9. *2010-2012 An Open-Label Study To Assess The Safety, Tolerability And Efficacy Of Canakinumab (ACZ885) In Patients Aged 4 Years Or Older Diagnosed With Cryopyrin-Associated Periodic Syndromes In Canada. Amount total: $13,299.00 Details: Protocol # CACZ885DCA01 Source: Novartis Role: Site Principal Investigator P Miettunen, Co-Investigators: H Schmeling, N Johnson 10. * 2010-2012 A Randomized, DoubleBlind, Placebo Controlled, Single-Dose Study To Assess The Initial Efficacy Of Canakinumab (ACZ885) With Respect To The Adapted ACR Pediatric 30 Criteria In Patients With Systemic Juvenile Idiopathic Arthritis (SJIA) And Active Systemic Manifestations. Amount total: $6,403.00 Details: Protocol

#CACZ885G2305 Source: Novartis Role: Site Principal Investigator P Miettunen, Co-Investigators: H Schmeling, N Johnson 11. *2012-2014 Canadian Pediatric Society Surveillance study: Periodic fever syndromes Co-investigator for Canadian Pediatric Society’s Surveillance Program on Periodic Fevers. Amount total: $40,000 Source: Novartis Role: Principal investigator P Dancey, Memorial University, Co-Investigators: P Miettunen, H Schmeling, N Johnson Co-investigators Susanne Benseler, MD, University of Toronto 12. *06/2009-06/2013 Pharmacogenetics Of Juvenile Idiopathic Arthritis – The Influence Of SingleNucleotide Polymorphisms In Candidate Genes On The Efficacy And Toxicity Of Etanercept. Amount: $72,000 Source: Pfitzer (Wyeth) Germany Role: Primary Investigator H Schmeling, CoInvestigator P Miettunen 13. *2012-2014 A phase I pharmacokinetic and safety study of tocilizumab in sJIA patients less than 2 years old Amount: $22,013

Source: Hoffman-la Roche Role: Site Primary Investigator H Schmeling, Co investigators: P Miettunen, N Johnson 14. *2012-2013 Parental Burden of RSV Amount: $15,975.67 Source: Abbott International Role: Principal Investigator I Mitchell 15. *2004-2013 Canadian Study of Palivizumab Amount: $6,275,0000 Source: AbbVie, Canada Role: Principal Investigator I Mitchell, Co Investigators B Paes, K Lanctot 16. *1999-Ongoing RSV Prevention in Calgary Amount: $ 639,175.00 Source: AbbVie Canada Role: Principal Investigator I Mitchell 17. *2009-2013 Randomized doubleblind, placebo controlled withdrawal trial to evaluate the efficacy and safety of tocilizumab in polyarticular juvenile idiopathic arthritis Amount: $137,442 Source: Hoffman-la Roche Role: Site Primary Investigator H Schmeling, Co investigators: P Miettunen, N Johnson

Department of Paediatrics | Annual Report 2013

18. *2011-2014 Pertussis Vaccine in Pregnancy Amount: $213,683.00 Source: Sanofi Pasteur Role: Site Primary Investigator O Vanderkooi, S Kuhn, JD Kellner Co- Investigator 19. *2007-2012 The Epidemiology of Pediatric Inflammatory Bowel Disease in the Western Region of North America (IBD Study) Amount balance: (3,667.44) General Classification: Grant General Operating Sponsor: Cedars-Sinai Medical Centre Role: Principal Investigator: Wrobel I 20. *2008-Ongoing Adalimumab in Pediatric Subjects with Moderate to Severe Crohn’s Disease General Classification: Contract Clinical Trials Amount balance: $11,875.54 Source: Abbott Laboratories Role: Primary Investigator Wrobel I 21. **2012-Present Infliximab IBD Influenza Vaccine Study: Effect of Influenza Vaccination Timing on Immune Response in Patients with Inflammatory Bowel Disease on Infliximab Amount: $107,006.40 Source: Janssen Inc.

Primary Investigator: deBruyn J 22. **2012-Present Serum infliximab levels and pharmacokinetics following first infliximab dose for induction of remission in children with moderate to severely-active ulcerative Source: Future Leaders in IBD (Janssen Inc) & Prometheus Amount: $375,000.00 Role: Primary Investigator deBruyn J 23. **2012-2013 Fetal Programming of Infant Stress Reactivity and Atopic Disease Amount: $35,000 Source: AllerGen Initiative Role: Primary Investigator Giesbrecht, GF, Co-Investigators: Letourneau, N., Kozyrskyj Kaplan B, Field C, Manhane P, Wynne-Edwards K, Campbell T, Soares C 24. ** 2012-present A Multicenter, Randomized, Double-blind, Placebocontrolled Study to Evaluate the Efficacy and Safety of Saxagliptin (BMS-477118) in Combination with Metformin IR or Metformin XR in Pediatric Patients with Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone Amount: $14 365.52 per patient Source: Bristol Myers

Annual Report 2013 | Department of Paediatrics

Squibb, Inc. Role: Site Primary Investigator J Ho, Co-Investigators D Pacaud, C. Huang, R. Perry 25. **2012-Present Human Heterologous Liver Cells for Infusion in Children with Urea Cycle Disorders (SELICA III) Amount: $166,000/patient Source: Cytonet Local Primary Investigator: Aneal Khan, Co-investigator S Martin 26. **2013 Strategies to enhance stem cell mediated mitochondrial transfer: potential for the treatment of mitochondrial disease. Amount: $50,000 Source: MitoCanada Role: Primary Investigator: Shearer J; Co-Investigators: Rho J, Martin S, Khan A 27. **2012-2015 An Open-Label Study for previously Treated Ataluren (PTC124) Patients with Nonsense Mutation Dystrophinopathy Amount: $2500 (during 2012-13): $2500 Total: $10,000 Source: PTC Therapeutics Role: Primary Local Investigator JK Mah 28. **2012-2013 RSV Prevention in Calgary Amount: $ 147,340

Source: AbbVie Canada Role: Principal investigator I Mitchell 29. **12/2012-03/201 A Phase IV study to evaluate decreased dose frequency in patients with systemic juvenile idiopathic arthritis (sJIA) who experience laboratory abnormalities during treatment with Tocilizumab Amount: $32,534 30. Source: Hoffman-la Roche Role: Site Primary Investigator H Schmeling 31. **2013-2015 A phase Ib, openlabel, multicenter study to investigate the pharmacokinetics, pharmacodynamics, and safety of tocilizumab following subcutaneous administration to patients with systemic juvenile idiopathic arthritis. Amount: $56,954 Source: Hoffman-la Roche Role: Site Primary Investigator H Schmeling 32. **2012-2023 A Multi-center, Randomized Parallel Group, PlaceboControlled Double-Blind Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of Belimumab, a Human Monoclonal Anti-BLyS

Antibody, Plus Standard Therapy in Pediatric Patients with Systemic Lupus Erythematosus (SLE) Amount: $335,870 Source: GlaxoSmithKline/ HGS Role: Site Co Investigator H Schmeling 33. **2013-2015 A phase Ib, openlabel, multi-center study to investigate the pharmacokinetics, pharmacodynamics, and safety of tocilizumab following subcutaneous administration to patients with polyarticular course juvenile idiopathic arthritis Amount: $49,194 Source: Hoffman-la Roche Role: Site Primary Investigator H Schmeling **2012-2015 A multi-center, openlabel study to assess the pharmacokinetics, safety, and efficacy of certolizumab pegol in children and adolescents with moderately to severely active polyarticular-course juvenile idiopathic arthritis Amount: $278,680 Source: UCB Biosciences Inc Role: Site Primary Investigator H Schmeling

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Peer-Reviewed Research Publications

1. Smyth D, Al Awad E, Akierman A, Remington T, Barber D, Vayalumkal J. Eosinophilic Pustular Folliculitis In A Premature Infant: Case Report And Literature Review. Journal Of NeonatalPerinatal Medicine 2012(5):179-182 2. Alshaikh B, Dersch Mills D, Taylor R, Akierman AR, Yusuf K. Extended Interval Dosing Of Gentamicin In Premature Neonates ≤ 28Week Gestation. Acta Paediatr 2012 Nov; 101(11):1134-9. 3. Dersch-Mills D, Alshaikh B, Akierman AR, Yusuf K. Validation Of A Dosage Individualization Table For Extended Interval Gentamicin In Neonates. 4. Annals of Pharmacotherapy 2012 Jul-Aug; 46(7-8): 935-42. 5. Amin HJ, Aziz K, Halamek L, Beran T. SimulationBased Learning Combined

Annual Report 2013 | Department of Paediatrics

with Debriefing: Trainers Satisfaction with a New Approach to Training the Trainers to Teach Neonatal Resuscitation. BMC Research Notes 2013; 6:251. 6. Li K, Thomas MA, Haber RM. Ulerythema Ophryogenes: A Rarely Reported Cutaneous Manifestation Of Noonan Syndrome. Case Report And Review Of The Literature. Journal of Cutaneous Medicine and Surgery Med Surg. 2013 MayJun;17(3):212-8 7. Myers KA, Thomas MA, Wei XC and Scantlebury MH. Case Report: Cleidocranial Dysplasia In A Neonate With Apneas And Tonsillar Herniation. Journal of Pediatrics 2013 Jul; (Accepted) 8. Zucker M, Clarke M, vanWylick R, Bernstein S, Au H, Talarico S, McKassey K, Grimmer J, Baron T, Moddemann D, Hyman J, McConnell A, Bannister S, Johnson N, Midgley J,

Lewis M, Forbes K, Lee J, Virji M, Aitkenson V et al. Canuc-paeds: Canadian Undergraduate Curriculum in Paediatrics developed by PUPDOC (thePaediatric Undergraduate Program Directors of Canada) http:// canucpaeds.pbworks. com/w/page/54470748/ canuc-paeds%20homepage 9. Barlow KM. Characteristics Of Post-Traumatic Headaches In Children Following Mild Traumatic Brain Injury And Their Response To Treatment: A Prospective Cohort. Dev Med Child Neurol. 2013 Jul;55(7):636-41. Epub 2013 Apr 5. 10. Hamilton M , Genge A, Johnston M, Lam D, Mobach T, Marriott J, Steeves T, Donner E, Wysocki J, Barlow K, Shevell M, Marrie RA, Casha S, Mackean G, Casselman L, Korngut L, Pringsheim , Jette N, "Patient Recruitment By Neurological Registries.", The Canadian Journal of

Neurological Sciences. 2013;40(4 Suppl 2) 11. Barlow K. Weight Gain After Childhood Traumatic Brain Injury. Dev Med Child Neurol. 2012;54(7):583. 12. Macciocchi S, Seel RT, Warshowsky A, Thompson N, Barlow K. Co-Occurring Traumatic Brain Injury And Acute Spinal Cord Injury Rehabilitation Outcomes. Arch Phys Med Rehabil. 2012;93(10):1788-94. 13. Girotto F, Scott L, Avchalumov Y, Harris J, Iannattone S, DrummondMain C, Tobias R, BelloEspinosa L, Rho JM, Davidsen J, Teskey GC, Colicos MA. High Dose Folic Acid Supplementation Of Rats Alters Synaptic Transmission And Seizure Susceptibility In Offspring. Sci Rep. 2013;3:1465. 14. Hrabok M, Sherman EM, Bello-Espinosa L, Hader W. Memory And

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Health-Related Quality Of Life In Severe Pediatric Epilepsy. Pediatrics. 2013Feb;131(2):e525-32. 15. Verhey LH, Branson HM, Laughlin S, Shroff MM, Benseler SM, Feldman BM, Streiner DL, Sled JG, Banwell B. Development of a Standardized MRI Scoring Tool for CNS Demyelination in Children. Am J Neuroradiol. 2013 Jun;34(6):1271-7. 16. Kuemmerle-Deschner JB, Wittkowski H, Tyrrell PN, Koetter I, Lohse P, Ummenhofer K, Rees F, Hansmann S, Koitschev A, Deuter C, Bialkowski A, Foell D, Benseler SM. Treatment Of Muckle-Wells Syndrome: Analysis Of Two Il-1-Blocking Regimens. Arthritis Res Ther. 2013 May 29;15(3):R64. 17. Jones KC, Benseler SM, Moharir M. Anti-NMDA Receptor Encephalitis. Neuroimaging Clin N Am. 2013 May;23(2):309-20.. 18. Moharir M, Shroff M, Benseler SM. Childhood Central Nervous System Vasculitis. Neuroimaging Clin N Am. 2013 May;23(2):293-308. 19. Lim LS, Lefebvre A, Benseler SM, Silverman ED. Longterm Outcomes And Damage Accrual In Patients With Childhood Systemic

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Lupus Erythematosus With Psychosis And Severe Cognitive Dysfunction. J Rheumatol. 2013 Apr;40(4):513-9. 20. Lim LSH, Lefebvre A, Benseler SM, Peralta M, Silverman ED. Psychiatric Illness Of Systemic Lupus Erythematosus In Childhood: Spectrum Of Clinically Important Manifestations. J Rheumatol. 2013 Apr;40(4):506-12. 21. Kuemmerle-Deschner J, Koitchev A, Gramlich K, Hansmann S, Plontke S, Koitchev C, Koetter I, Angermair E, Benseler SM. Hearing Loss In Muckle-Wells Syndrome. Arthritis Rheum. 2013 Mar;65(3):824-31. 22. Titulaer M, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig L, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld M, BaliceGordon R, Graus F, Dalmau J. Treatment And Prognostic Factors For Long-Term Outcome In Patients With Anti-N-Methyl-D-Aspartate (Nmda) Receptor Encephalitis: A Cohort Study. Lancet Neurol. Lancet Neurol. 2013 Feb;12(2):157-65. 23. Hugle B, Haas JP, Benseler SM. Treatment Preference In

Juvenile Idiopathic Arthritis – A Comparative Analysis In Two Health Care Systems. Pediatr Rheumatol Online J. 2013 Jan 15;11(1):3. 24. Moran CJ, Walters TD, Guo CH, Kugathasan S, Klein C, Turner D, Wolters VM, Bandsma RH, Mouzaki M, Zachos M; NEOPICS, Langer JC, Cutz E, Benseler SM, Roifman CM, Silverberg MS, Griffiths AM, Snapper SB, Muise AM.IL-10R Polymorphisms Are Associated With Very-EarlyOnset Ulcerative Colitis. Inflamm Bowel Dis. 2013 Jan;19(1):115-123. 25. Batthish M, Banwell B, Laughlin S, Halliday W, Peschken C, Paras E, Benseler SM. Refractory Primary CNS Vasculitis of Childhood: Successful Treatment with Infliximab. The Journal of Rheumatology 2012 Nov;39(11):2227-9. 26. Gowdie P, Twilt M, Benseler SM. Primary And Secondary Central Nervous System Vasculitis. Journal of Child Neurology 2012 Nov;27(11):1448-59. 27. Cellucci T, Tyrrell PN, Pullenayegum E, Benseler SM.von Willebrand Factor Antigen--A Possible Biomarker Of Disease Activity In Childhood Central Nervous System Vasculitis?

Rheumatology (Oxford). 2012 Oct;51(10):1838-45. 28. Morishita K, Guzman J, Chira P, Zeft AS, Klein-Gitelman M, Uribe AG, Abramson L, Ballinger S, Benseler SM, Campillo S, Eberhard A, Eichenfield A, Hashkes PJ, Hersh AO, Higgins G, Jerath R, Jung L, Kim S, Kingsbury DJ, Li SC, Lovell DJ, Mason T, McCurdy D, Muscal E, Nassi L, O’Neil KM, Onel K, Rabinovich E, Ramsey S, Reiff A, Rosenkranz M, Schikler K, Singer N, Spalding S, Stevens A, Wahezi D, Zemel L, Cabral DA. Do Adult Disease Severity Subclassifications Predict Use Of Cyclophosphamide In Children With AncaAssociated Vasculitis? An Analysis of ARChiVe Study Treatment Decisions. Journal of Rheumatology. 2012 Oct;39(10):2012-20. 29. Lim LS, Benseler SM, Tyrrell PN, Harvey E, Herbert D, Charron M, Silverman ED. Predicting Longitudinal Trajectory Of Bone Mineral Density In Paediatric Systemic Lupus Erythematosus Patients. Ann Rheum Dis. 2012 Oct;71(10):1686-91. 30. Soon GS, Rodan LH, Laughlin S, Laxer RM, Benseler SM, Silverman ED. reversible splenial lesion syndrome in

Pediatric Systemic Lupus Erythematosus. J Rheumatol. 2012 Aug;39(8): 1698-9. 31. Dolezalova P, Price-Kuehne FE, Ozen S, Benseler SM, Cabral DA, Anton J, Brunner J, Cimaz R, O'Neil KM, Wallace CA, Wilkinson N, Eleftheriou D, Demirkaya E, Böhm M, Krol P, Luqmani RA, Brogan PA. Disease Activity Assessment In Childhood Vasculitis: Development And Preliminary Validation Of The Paediatric Vasculitis Activity Score (Pvas). Ann Rheum Dis. 2012 Oct 25. 32. Uribe AG, Huber AM, Kim S, O'Neil KM, Wahezi DM, Abramson L, Baszis K, Benseler SM, Bowyer SL, Campillo S, Chira P, Hersh AO, Higgins GC, Eberhard A, Ede K, Imundo LF, Jung L, Kingsbury DJ, KleinGitelman M, Lawson EF, Li SC, Lovell DJ, Mason T, McCurdy D, Muscal E, Nassi L, Rabinovich E, Reiff A, Rosenkranz M, Schikler KN, Singer NG, Spalding S, Stevens AM, Cabral DA. Increased Sensitivity Of The European Medicines Agency Algorithm For Classification Of Childhood Granulomatosis With Polyangiitis.J Rheumatol. 2012 Aug:39(8):1687-97. 33. Koitschev A, Gramlich K,

Department of Paediatrics | Annual Report 2013

Hansmann S, Benseler S, Plontke SK, Koitschev C, Koetter I, KuemmerleDeschner JB. Progressive Familial Hearing Loss In Muckle-Wells Syndrome. Acta Otolaryngol. 2012 Jul;132(7):756-62. 34. Benseler S, Pohl D. Childhood Central Nervous System Vasculitis. Handb Clin Neurol. 2013;112:1065-78. 35. Pohl D, Benseler S. Systemic Inflammatory And Autoimmune Disorders. Handb Clin Neurol. 2013;112:1243-52. 36. Lynch DC, Dyment DA, Huang L, Nikkel SM, Lacombe D, Campeau PM, Lee B, Bacino CA, Michaud JL, Bernier FP. FORGE Canada Consortium, Parboosingh JS, Innes AM. Identification Of Novel Mutations Confirms Pde4d As A Major Gene Causing Acrodysostosis. Hum Mutat. 2012;34(4):667. 37. Letourneau N, Giesbrecht GF, Bernier FP, Joschko J. How Do Interactions Between Early Caregiving Environment and Genes Influence Health and Behavior? Biol Res Nurs. 2012 Oct 24. [Epub ahead of print] 38. Bouchard S, Bernier F, Boivin É, Dumoulin S, Laforest M, Guitard T,

Robillard Monthuy-Blanc J, Renaud P. Empathy Toward Virtual Humans Depicting A Known Or Unknown Person Expressing Pain. Cyberpsychol Behav Soc Netw. 2013 Jan;16(1):61-71. 39. Kaplan BJ, Leung BM, Giesbrecht GF, Field CJ, Bernier FP, Tough S, Cui X, Dewey D; APrON Study Team. Increasing The Quality Of Life From Womb To Grave: The Importance Of Pregnancy And Birth Cohorts. Appl Physiol Nutr Metab. 2013 Jan; 38(1):85-9. 40. Sawyer SL, Dicke F, Kirton A, Rajapkse T, Rebeyka IM, McInnes B, Parboosingh JS, Bernier FP. Longer Term Survival Of A Child With Autosomal Recessive Cutis Laxa Due To A Mutation In Fbln4. Am J Med Genet 2013 Mar 26. Epub ahead of print. 41. Sawyer S, Dickie F, Kirton A, Parboosingh J,Bernier FP. Longer Term Survival Of A Child With Autosomal Recessive Cutis Laxa Due To A Novel Fibulin 4 Mutation. Am J Med Genet 2013 May;161(5):1148-53. 42. MetcalfeA, Currie G, Johnson JA, Bernier F, Lix LM, Lyon AW, Tough SC. Impact Of Observed Versus Hypothesized Service Utilization On The Incremental Cost Of First

Annual Report 2013 | Department of Paediatrics

Trimester Screening And Prenatal Diagnosis For Trisomy 21 In A Canadian Province. Prenat Diagn 2013;33(5):429-35. 43. Metcalfe A, Lix LM, Johnson JA, Bernier F, Currie G, Lyon AW, Tough SC. Assessing the Impact of the Sogc Recommendations to Increase Access to Prenatal Screening on Overall Use of Health Resources in Pregnancy.. J Obstet Gynaecol Can 2013;35(5):444-53. 44. Bjornson CL, Johnson DW. Introduction to Clinical Answers: Croup. Evid.Based Child Health 2012; 7: 883-885. 45. Paes B, Mitchell I, Li A, Lanctôt KL, CARESS investigators (Allen U, Bacheyie G, Bayliss A, Bjornson C, Blayney M, Canakis AM, Canning R, Caouette G, Chang K, Chang L, Chiu A, DiGravio B, Doray JP, Dumas ME, Ho V, Hui C, Jagdis F, Lebel M, Lee D, Majaesic C, Margolis I, Mitchell M, O'Brien K, Ojah C, Papageorgiou A, Popovich J, Sankaran K, Simmons B, Stinson D, Bjornson C, Caouette G, Lebel M, Dumas ME, Hui C, Bayliss A, DiGravio B, Doray JP, Stinson D, Papageorgiou A, Mitchell M, Chiu A, Paes B, Canning R, Canakis AM, O'Brien

K, Chang K, Sankaran K, Ho V, Allen U, Chang L, Ojah C, Lee D, Majaesic C, Blayney M, Popovich J, Jagdis F, Margolis I, Osler W, Bacheyie G, Simmons B). A Comparative Study Of Respiratory Syncytial Virus (Rsv) Prophylaxis In Premature Infants Within The Canadian Registry Of Palivizumab (Caress). Eur J Clin Microbiol Infect Dis. 2012 Oct;31(10):2703-11. Epub 2012 May 1.

Retention Does Not Have To Be The Rule: Retention Of Volunteer Community Health Workers In Uganda Health Policy Plan. 2013 May 6. Epub ahead of print 50. Buchhalter JR. The Relationship Between Nocturnal Discharges And Language Dysfunction In Rolandic Epilepsy: Treat The Child, Not The Adage. Epilepsy Curr. 2012 Sep;12(5):192-3.

46. Lynch DC, Dyment DA, Huang L, Nikkel SM, Lacombe D, Campeau PM, Lee B, Bacino CA, Michaud JL, Bernier FP; FORGE Canada Consortium, Parboosing JS, Innes AM. 2013. Identification Of Noel Mutations Confirms Pde4d As A Major Gene Causing Acrodysostosis. Hum Mutat. 34:97-102.

51. Buchhalter J. Diagnostic Coding For Epilepsy. Continuum (Minneap Minn). Epilepsy 2013;19(3):806-12.

47. Bray S, Arnold A, Iaria G, MacQueen G. Structural Connectivity Of Visuotopic Intra-Parietal Sulcus. NeuroImage 2013;82:137-45.

53. Buchhalter J, Stang A. Commentary On ‘Propofol Versus Thiopental Sodium For The Treatment Of Refractory Status Epilepticus-Still No Answer. Evid. Based Child Health 8: 1509-1510 (2013)

48. B ray S, Hoeft F, Hong DS, Dunkin B, Reiss A. Aberrant Functional Network Recruitment Of Parietal Cortex In Turner Syndrome. Human Brain Mapping 2013; 34(12):3117-28. 49. Ludwick T, Brenner JL, Kyomuhangi T, Wotton KA, Kabakyenga JK. Poor

52. Morgan LA, Dvorchik I, Williams KL, Jarrar RG, Buchhalter JR. Parental Ranking Of Terms Describing Nonepileptic Events. Pediatr Neurol. 2013;48(5):378-82.

54. Al-Hussaini A, Butzner D. Therapeutic Applications of Octreotide in Pediatric Gastroenterology. Saudi J Gastroenterol. 18: 87-94, 2012. 55. Soon IS, Butzner JD,

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Kaplan GG, deBruyn JC. Incidence and Prevalence of Eosinophilic Esophagitis in Children: Systemic Review and Meta-Analysis. J Pediatr Gastroenterol Nutr. 57: 7280, 2013. 56. Sigalet DL, Kravarusic D, Butzner D, Hartmann B, Holst JJ, Meddings J. A pilot study examining the relationship among Crohn disease activity, glucagonlike peptide-2 signalling and intestinal function in pediatric patients. Can J Gastroenterol. 27: 587-92, 2013.

health resource utilization in pregnancy. J Obstet Gynaecol Can 2013; 35(5): 444-453. 60. Metcalfe A, Currie G, Johnson J, Bernier F, Lix LM, Lyon AW, Tough SC. Impact of observed versus hypothesized service utilization on the incremental cost of first trimester screening and prenatal diagnosis in a Canadian province. Prenat Diagn 2013; 33(5): 429-35.

58. Lancsar E, Louviere J, Donaldson C, Currie G, Burgess L. Best worst discrete choice experiments in health: Methods and an application, Social Science & Medicine, Volume 76, January 2013, Pages 74-82.

61. Cheng A, Hunt EA, Donoghue A, NelsonMcMillan K, Nishisaki A, LeFlore J, Eppich W, Moyer M, Brett-Fleegler M, Kleinman M, Anderson J, Adler M, Braga M, Kost S, Stryjewski G, Min S, Podraza J, Lopreiato J, Fiedor Hamilton M, Stone K, Reid J, Hopkins J, Manos J, Duff J, Richard M, Nadkarni V, for the EXPRESS Investigators. Examining Pediatric Resuscitation Education Using Simulation and Scripting (EXPRESS): A Multicenter, RandomizedControlled Trial. JAMA Pediatrics, epub ahead of print, April 22, 2013. PI

59. Metcalfe A, Lix LM, Johnson J, Bernier F, Currie G, Lyon AW, Tough SC. Assessing the impact of the SOGC recommendations to increase access to prenatal screening on overall

62. Duff J, Cheng A, Bahry L, Hopkins J, Richard M, Schexnayder S, Carbonaro M. Development and Validation of a Multiple Choice Examination Assessing Cognitive and

57. Sigalet E, Donnon T, Cheng A, Cooke S, Robinson T, Bissett W, Grant V. Development of a team performance scale to assess undergraduate health professionals. Acad Med 2013;88(7):989-96.

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Behavioural Knowledge of Pediatric Resuscitation: A Report from the EXPRESS Pediatric Research Collaborative. Resuscitation, July 25, 2012 epub ahead of print. 63. Hung G, Bialy L, Cheng A. Pediatric Emergency Medicine Fellows Education Day: Addressing CanMEDS Objectives in a National Forum. Peds Child Health. 2012. 17(10):544-548. SI 64. Cheng A, Rodgers D, Van Der Jagt E, Eppich W, Oâ&#x20AC;&#x2122;Donnell J for the American Heart Association Pediatric Subcommittee. Evolution of the Pediatric Advanced Life Support Course: Enhanced Learning with a New Debriefing Tool and Webbased Module for Pedaitric Advanced Life Support Instructors. Pediatric Critical Care Medicine. 2012; 13(5): 589-595. PA 65. Grant E, Grant VJ, Bhanji F, Duff J, Cheng A, Lockyer J. The Development and Assessment of an Evaluation Tool for Pediatric Resident Competence in Leading Simulated Pediatric Resuscitations. Resuscitation. 2012; 83(7):887-893. C 66. Qayumi K, Donn S, Zheng B, Young L, Dutton J, Adamack M, Bowles R, Cheng A. British Columbia Interprofessional

Model for Simulation-Based Education in Healthcare â&#x20AC;&#x201C; A Network of Simulation Sites. Simulation in Healthcare. 2012; 7:295-307. SI 67. Brett-Fleegler M, Rudolph J, Eppich W, Fleegler E, Cheng A, Simon R. Debriefing Assessment for Simulation in Healthcare (DASH) : Development and Psychometric Properties. Simulation in Healthcare. 2012; 7:288-294. C 68. Bretholz A, Doan Q, Lauder G, Cheng A. A Pre and Post Survey of a Web and Simulation-Based Course of Ultrasound-Guided Nerve Blocks for Pediatric Emergency Medicine. Pediatric Emergency Care. 2012; 28:506-509. SI 69. Cheng A, Donoghue A, Gilfoyle E, Eppich W. Simulation-based crisis resource management training for pediatric critical care medicine: A review for instructors. Ped Crit Care Med. 2012. 13(2):197-203. PA 70. Ortiz-Alvarez O, Mikrogianakis M, Cheng A et al. Management of the Pediatric Patient with an Acute Asthma Exacerbation. Pediatr Child Health. 2012. 17(5):251-256. C (National Guideline) 71. Sam J, Pierse M, Al-

Qahtani Q, Cheng A. Implementation and Evaluation of a Simulation Curriculum for Pediatric Residency Programs including Just in Time In-Situ Mock Codes. Pediatrics and Child Health. Pediatr Child Health. 2012, 17(1):1-5. SI 72. Soon Is, deBruyn JC, Wrobel I. Immunization History of Children with Inflammatory Bowel Disease. Can J Gastroenterol. 2013 Apr; 27(4): 213-6 73. Debruyn JC, Hilsden R, Fonseca K, Russell ML, Kaplan GG, Vanderkooi O, Wrobel I. Immunogenicity and Safety of Influenza Vaccination in Children with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2012;18(1):25-33. 74. Charles, E., Thomas, D.S., Dewey D., Davey, M., Ngallaba, S.E., & Konje E. (January 2013). A cross-sectional survey on knowledge and perceptions of health risks associated with arsenic and mercury contamination from artisanal gold mining in Tanzania, BMC Public Health, 13, 74. 75. Ray, M., Dewey. D., Kooistra, L., & Welsh, T.N. (June 2013). The relationship between the motor system activation during action observation

Department of Paediatrics | Annual Report 2013

and adaptation in the motor system following repeated action observation. Human Movement Science, 32, 400-411. 76. Kuczynski A, Crawford S, Bodell L, Dewey D, Barlow KM. Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol. 2013;55(7):636-41. 77. Ouellette-Kuntz H, Coo H, Lam M, Breitenbach MM, Hennessey PE, Jackman PD, Lewis ME, Dewey D, Bernier FP, Chung AM."The Changing Prevalence of Autism in Three Regions of Canada." [In Eng]. J Autism Dev Disord (Jun 16 2013) 23771514. 78. SL, Dicke F, Kirton A, Rajapkse T, Rebeyka IM, McInnes B, Parboosingh JS, Bernier FP. llevterm survival of a child with autosomal recessive cutislaxa due to a mutation in FBLN4. Am J Med Genet A. 2013;161A(5):1148-53. 79. Meeting the Health Care Needs of Street Involved Youth. April S Elliott; Canadian Paediatric Society, Adolescent Health Committee . Paediatr Child Health 2013;18(6):317-21

80. Myers KA, Payne ET, Esser MJ, Kirton A, Howard JJ. Thoracic myelopathy secondary to seizure following scoliosis surgery. J Child Neurol. 2012;27(7):914-6. 81. Gamble C, Gamble J, Ali S, Wright B, Seal R. Bispectral Analysis During Procedural Sedation in the Pediatric Emergency Department. Pediatric Emergency Care. 2012 Oct;28(10):1003-1008. 82. Giesbrecht G, Letournaeau N, Campbell T, Kaplan B J & the APrON Study Team (Dec 2012). Affective experience in ecologically relevant contexts is dynamic, and not progressively attenuated. Archives of Women’s Mental Health. 15(6):481-485 83. Giesbrecht GF, Granger D, Campbell T, Kaplan BJ & the APrON Study Team (March 2013). Salivary alpha-amylase during pregnancy: Diurnal course and associations with obstetric history, maternal characteristics and mood. Developmental Psychobiology. 55, 156-167 84. Sigalet E, Donnon T, Grant V. Undergraduate students' perceptions of and attitudes toward a simulation-based interprofessional curriculum: The KidSIM ATTITUDES questionnaire. Simul Healthc 2012;7(6):353-8.

Annual Report 2013 | Department of Paediatrics

Epub 2012 Aug 16. 85. Grisaru S, Watson-Jarvis K, McKenna C, Ho J, Harder J, Trussell B. Development of a Simple Tool for Diagnosis and Initial Approach to Hypertension and Prehypertension in Children and Youth. Open Journal of Pediatrics. June 2012; 2(2):106-110 86. Decloe M, Emery CA, Hagel BE, Meeuwisse WH. Injury rates, types, mechanisms and risk factors of injury in female youth ice hockey. British Journal of Sports Medicine. 2014;48(1):51-6. Epub 2013 Feb 27. 87. Romanow NTR, Hagel BE, Nguyen M, Embree T, Rowe BH. Mountain bike terrain park injuries: an emerging cause of morbidity. International Journal of Injury Control and Safety Promotion. 2012 Dec 18. [Epub ahead of print] 88. Morrongiello BA, Sandomierski M, Hagel BE, Schwebel DC. Are parents just treading water? The impact of participation in swim lessons on parents’ judgments of children’s drowning risk, swimming ability, and supervision needs. Accident Analysis & Prevention 2013; 50:1169-75. 89. Blake T, Hagel BE, Emery

CA. Sport Medicine Journal Club: “Does Intentional or Unintentional Contact in Youth Ice Hockey Result in More Injuries?” [Commentary] Clinical Journal of Sport Medicine 2012;22(4): 377–378. 90. Davison K, Kaplan BJ . Nutrient- and non-nutrientbased natural health product (NHP) use in adults with mood disorders: prevalence, characteristics and potential for exposure to adverse events. BMC Complementary and Alternative Medicine 2013;13(1):80. 91. Kaplan BJ, Geisbrecht GF, Leung BMY, Field CJ, Dewey D, Bell RC, Manca DP, O’Beirne M, Johnston DW, Pop VJ, Singhal N, Gagnon L, Bernier FP, Eliasziw M, McCargar LJ, Kooistra L, Farmer A, Cantell M, Goonewardene L, Casey LM, Letourneau N, Martin JW. (July 17 2012). The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study: Rationale and Methods. Maternal and Child Nutrition Matern Child Nutr. 2014 Jan;10(1):44-60. Epub 2012 Jul 17. 92. Giesbrecht G, Campbell T, Letourneau N, Kaplan B, and the APrON Study Team (April 2013). Advancing gestation does not attenuate biobehavioural coherence

between psychological distress and cortisol. Biological Psychology 93: 45– 51. 93. Miller M, Giesbrecht GF, McInerney J, Kerns K, & Müller, U. (2012). A latent variable approach to determining the structure of executive function in preschool children. Journal of Cognition and Development, 13, 395-423. 94. Chamorro-Viña C, Guilcher GM, Khan FM, Mazil K, Schulte F, Wurz A, Williamson T, Reimer RA, Culos-Reed SN. EXERCISE in pediatric autologous stem cell transplant patients: a randomized controlled trial protocol. BMC Cancer Sep 10;12:401. 2012. 95. Sigalet E, Donnon T, Grant V. Undergraduate Students' Perceptions of and Attitudes Toward a SimulationBased Interprofessional Curriculum: The KidSIM ATTITUDES Questionnaire. Simulation in Healthcare 2012;7(6):353-8. 96. Grant EC, Grant VJ, Bhanji F, Duff JP, Cheng A, Lockyer JM. The development and assessment of an evaluation tool for pediatric resident competence in leading simulated pediatric resuscitations. Resuscitation 2012;83(7):887-93.

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97. Grueger B and Canadian Paediatric Society Community Paediatrics Committee. Weaning from the breast. 98. Pediatrics & Child Health 2013;18(4):210-11. 99. Gross ML, Tenenbein M, Sellers EAC. Severe vitamin D deficiency in 6 Canadian First Nation formula-fed infants. Int J Circumpolar Health 2013;72: 20244 100. Harabor A, Fruitman D. Comparison between a suprasternal or high parasternal approach and an abdominal approach for measuring superior vena cava Doppler velocity in neonates. J Ultrasound Med. 2012 Dec; 31(12):1901-7. 101. Hasan SU, Yusuf K. Rat homologues to the human post neonatal period: Modes for vulnerability to the sudden infant death syndrome. Pediatr Pulmonol 2012 July; 47:731. 102. Nair V, Hasan SU, Romanchuk K, Al Awad E, Mansoor A, Yusuf K. Bilateral Cataracts Associated with Glucose-6Phosphate Dehydrogenase Deficiency. J Perinatol, 2013 Jul; 33(7):574-575.

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103. M. van Manen, L. Hendson, M Wiley, M. Evans, S. Taghaddos, I. Dinu. Early childhood outcomes of infants born with gastroschisis. J Ped Surg 2013;48:1682-1687. 104. Pepper D, Rempel G, Austin W, Ceci C, Hendson L. More than Information: A Qualitative Study of Parents' Perspectives on Neonatal Intensive Care at the Extremes of Prematurity. Advances in Neonatal Care 2012;12: 303-309. 105. Carney JA, Ho J, Kitsuda K, Stratakis CA, Young, WF. Massive neonatal adrenal enlargement due to cytomegaly, persistence of the transient cortex, and hyperplasia of the permanent cortex: Findings in Cushing Syndrome associated with hemihypertrophy. American Journal of Surgical Pathology. 2012;36(10):1452-1463. 106. Akierman S, Skappak C, Girgis R, Ho J. Turner Syndrome and apparent absent uterus: case report and review of literature. Journal of Paediatric Endocrinology and Metabolism February 2013; 26(5-6):587-589. 107. Nelson D, Ho J., Pacaud D., Stephure D. Virilization in

Two Pre-pubertal Children Exposed to Topical Androgen. Journal of Paediatric Endocrinology and Metabolism 2013 May 24:1-5. [Epub ahead of print] 108. Mameli C, Scaramuzza AE, Ho J, Cardona-Hernandez R, Suarez-Ortega L, Zuccotti G. A 7-year follow-up retrospective, international, multicenter study of insulin pump therapy in children and adolescents with type 1 diabetes. Acta Diabetologica 2013 May 17. [Epub ahead of print] 109. Huang C. Wild type offspring of heterozygous prolactin receptor null female mice have maladaptive betacell responses during pregnancy. Journal of Physiology 2013; 591 (Pt5): 1325-38. 110. Wiltshire KM, Hegele RA, Innes AM, Brownell KW. Homozygous Lamin A/C familial lipodystrophy R482Q mutation in autosomal recessive Emery Dreifuss Muscular Dystrophy. Neuromuscul Disord. 2013;23(3):265-8. 111. Beaulieu CL, Huang L, Innes, AM, Akimenko MA, Puffenberger EG, Schwartz C, Jerry P, Ober C, Hegele RA, McLeod DR,

Schwartzentruber J, FORGE Canada Consortium, Majewski J, Bulman DE, Parboosingh JS, Boycott KM. 2013. Intellectual Disability Associated with a Homozygous Missense Mutation in THOC6. Orphanet J Rare Dis. 2013 Apr 26;8(1):62. [Epub ahead of print] 112. Bögershausen N, Shahrzad N, Chong JX, von KleistRetzow J-C, Stanga D, Li Y, Bernier FP, Loucks CM, Wirth R, Puffenberger EG, Hegele R, Schreml J, Lapointe G, Keupp K,, Brett CL, Anderson R, Hahn A,, Innes AM, Suchowersky O, Mets MB, Nürnberg G, McLeod DR, Thiele H, Waggoner D, Altmüller J, Boycott KM, Schoser B, Nürnberg P, Ober C, Heller R, Parboosingh JS, Wollnik B, Sacher M, Lamont RE 2013. Recessive TRAPPC11 mutations cause a disease spectrum of limb girdle muscular dystrophy and myopathy with infantile hyperkinetic movements and intellectual disability. Am. J. Hum. Genet. 93:18190. 113. Dyment DA, Smith AC, Alcantara D, Schwartzentruber J, Basel-Vanagaite L, Curry CJ, Temple IK, Reardon W, Mansour S, Haq MR, Gilbert R, Lehmann OJ, Vanstone MR, Beaulieu CL, FORGE

Canada Consortium, Majewski J, Bulman DE, O’Driscoll M, Boycott KM, Innes AM. 2013. Mutations in PIK3R1 Cause SHORT Syndrome. Am J Hum Genet 93: 158-66. 114. Doherty D, Chudley AE, Coghlan G, Ishak GE, Innes AM, Lemire EG, Rogers RC, Mhanni AA, Phelps IG, Jones SJ, Zhan SH, Fejes AP, Shahin H, Kanaan M, Akay H, Tekin M; FORGE Canada Consortium, Triggs-Raine B, Zelinski T. GPSM2 mutations cause the brain malformations and hearing loss in ChudleyMcCullough syndrome. Am J Hum Genet. 2012 Jun 8;90(6):1088-93. Epub 2012 May 10. Erratum in: Am J Hum Genet. 2012 Jul 13;91(1):209. PubMed PMID: 22578326; PubMed Central PMCID:PMC3370271. 115. Bettinger JA, Scheifele DW, Le Saux N, Halperin SA, Vaudry W, Tsang R; Members of Canadian Immunization Monitoring Program, Active (IMPACT). (Jadavji, T Member) The disease burden of invasive meningococcal serogroup B disease in Canada. Pediatr Infect Dis J. 2013 Jan;32(1):e20-5. 116. Bettinger JA, Scheifele DW, Halperin SA, Vaudry W, Findlow J, Borrow R, Medini D, Tsang R;

Department of Paediatrics | Annual Report 2013

For the members of the Canadian Immunization Monitoring Program, Active (IMPACT). (Jadavji, T Member). Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB). Vaccine. 12 April 2013. 117. Coyle D, Coyle K, Bettinger JA, Halperin SA, Vaudry W, Scheifele DW, Le Saux N. Members of Canadian Immunization Monitoring Program, Active (IMPACT) (Jadavji, T; Vanderkooi, OG - Members) Cost effectiveness of infant vaccination for rotavirus in Canada. Canadian Journal of Infectious Diseases & Medical Microbiology 2012; 23(2): 71-77 118. Forbes JC, Alimenti AM, Singer J, Brophy JC, Bitnun A, Samson LM, Money DM, Lee TC, Lapointe ND, Read SE; Canadian Pediatric AIDS Research Group (CPARG). Collaborators: A AM, B A, Bortolussi B, Boucher F, B JC, Bullard J, Cohen J, Cooper R, Ellis M, Embree J, Forbes J, Hanley B, Jadavji T, Karatzios C, Lamarre V, L ND, Moore D, Onyett H, R SE, S LM, Sandre R, Siegel S, Smaill F, Sobol I, Sweet L, Tan

B, Vaudry W, Young M. A national review of vertical HIV transmission. AIDS. 2012 Mar 27;26(6):757-63. 119. McDermid A, Le Saux N, Grudeski E, Bettinger JA, Manguiat K, Halperin SA, Macdonald L, Déry P, Embree J, Vaudry W, Booth TF; Members of the Canadian Immunization Monitoring Program, Active. Collaborators: Morris R, Halperin S, Déry P, Moore D, Lebel M, Le Saux N, Tran D, Embree J, Tan B, Jadavji T, Vaudry W, Sauvé L. Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals. BMC Infect Dis. 2012 Nov 15;12:306. 120. Top KA, Constantinescu CM, Lafleche J, Bettinger JA, Scheifele DW, Vaudry W, Halperin SA, Law BJ, (IMPACT). (Jadavji, T Member).. Applicability of the Brighton Collaboration Case Definition for seizure after immunization in active and passive surveillance in Canada. Vaccine. 2013;31(48):5700-5. 121. Tran D, Vaudry W, Moore DL, Bettinger JA, Halperin SA, Scheifele DW, Aziz S; IMPACT investigators. Collaborators: Morris R, Halperin S, Déry P, Moore D, Lebel M, Saux N, Tran D, Embree J, Tan B, Jadavji

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T, Vaudry W, Sauvé L. Comparison of children hospitalized with seasonal versus pandemic influenza A, 2004-2009. Pediatrics. 2012 Sep;130(3): 397-406. 122. Manca DP, O’Beirne M, Lightbody T, Johnston DW, Dymianiw D-L, Nastalska K, Anis L, Loehr S, Gilbert A, Kaplan BJ, and the APrON Study Team (March 2013). The most effective strategy for recruiting a pregnancy cohort: A tale of two cities. BMC Pregnancy and Childbirth, 13:75. 123. Cellot S, Johnston D, Dix D, Ethier MC, Gillmeister B, Mitchell D, Yanofsky R, Lewis V, Portwine C, Price V, Zelcer S, Silva M, Bowes L, Michon B, Stobart K, Brossard J, Beyene J, Sung L. Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group. BMC Cancer Jun 4;13(1):276. 2013. 124. Rodway M, Vance A, Watters A, Lee H, Bos E, Kaplan BJ (2012 Nov 9), Efficacy and cost of micronutrient treatment of childhood psychosis. BMJ Case Reports 2012 Nov 9; 2012.

125. Kaplan BJ, Leung BM, Giesbrecht GF, Field CJ, Bernier FP, Tough S, Cui X, Dewey D, and the APrON Study Team (Jan 2013). Increasing the quality of life from womb to grave: The importance of pregnancy and birth cohorts. Appl Physiol Nutr Metab, 38(1):85-89. 126. Rucklidge JJ, Kaplan BJ (Jan 2013). Broad-spectrum micronutrient formulas for the treatment of psychiatric symptoms: A systematic review. Expert Reviews in Neurotherapeutics, 13(1):49-73. 127. Leung BMY, Kaplan BJ, Field CJ, Tough S, Eliasziw M, Gomez MF, McCargar LJ, Gagnon L, and the APrON Study Team (Jan 2013). Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort. BMC Pregnancy and Childbirth,13:2. 128. Field LL, Shumansky K, Ryan J, Truong D, Swiergala E, Kaplan BJ. (Feb 2013). Dense-map genome scan for dyslexia confirms loci at 4q13, 16p12, 17q22; suggests novel locus at 7q36. Genes, Brain and Behavior. 12(1):56-69. 129. Tran C, Gagnon F, Wigg KG, Feng Y, Gomez L, CateCarter TD, Kerr EN, Field

LL, Kaplan BJ, Lovett MW, Barr CL (March 2013) A Family-Based Association Analysis and MetaAnalysis of the Reading Disabilities Candidate Gene DYX1C1. American Journal of Medical Genetics (Neuropsychiatric Genetics), 162B:146–156. 130. Leung BM, Kaplan BJ, Field CJ, Tough S, Eliasziw M, Gomez MF, McCargar LJ, Gagnon L, APrON Study Team. Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort. BMC Pregnancy Childbirth. 2013 Jan; 13:2. 131. Bettinger JA, Scheifele DW, Halperin SA, Kellner JD, Vanderkooi OG, Schryvers A, DeSerres G, Alcantara J. Evaluation of Meningococcal Serogroup C Conjugate Vaccine Programs in Canadian Children: Interim Analysis. Vaccine 2012 ;30: 4023-27. 132. Daneman D, Kellner JD. Navigating the Stages of an Academic Career for Pediatricians. Paediatrics & Child Health 2012 June/ July;17(6):301-3. 133. VanderPluym C, Tawfik G, Hervas-Malo M, Lacaze-Masmonteil T, Kellner JD, Robinson

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J. Empiric Therapy of Possible Neonatal Herpes Simplex Virus Infection. Journal of Maternal-Fetal and Neonatal Medicine 2012;25(8):1278-82. 134. Yam KK, Gupta J, Brewer A, Scheifele DW, Halperin S, Ward BJ; Public Health Agency of Canada/ Canadian Institute of Health Research, Influenza Research Network (PCIRN) Rapid Trial Study 3 (RT-03) Investigators (Kellner JD, member). Unusual Patterns of IgG Avidity in Some Young Children Following Two Doses of the Adjuvanted Pandemic H1N1 (2009) Influenza Virus Vaccine. Clinical and Vaccine Immunology. 2013;20(4):459-67. 135. Kirk VG, Currie G, Dewey D, Howlett A, Lemieux L, Prince T.Innovation in Physician Recruitment & Wellness: A Pilot Orientation Program.Â J Pediatr 2013 162(4) 664-5 (supplement 665e1665e2) 136. Kirton A, Crone M, Benseler S, Mineyko A, Armstrong D, Wade A, Sebire G, CrousTsanaclis AM, Deveber G. Fibromuscular dysplasia and childhood stroke. Brain. 2013 Jun;136(Pt 6):1846-56.

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137. Kirton A. Predicting developmental plasticity after perinatal stroke. Dev Med Child Neurol. 2013;55(8):681-2. 138. Kirton A. Modeling developmental plasticity after perinatal stroke: defining central therapeutic targets in cerebral palsy. Pediatr Neurol. 2013;48(2):81-94. 139. Kirton A. Can noninvasive brain stimulation measure and modulate developmental plasticity to improve function in strokeinduced cerebral palsy? Semin Pediatr Neurol. 2013;20(2):116-26. 140. Rajapakse T, Kirton A. Noninvasive brain stimulation in children: applications and future directions. . Transl Neurosci. 2013;4(2). 141. Tuor UI, Qiao M, Morgunov M, Fullerton E, Foniok T, Kirton A. Magnetization transfer and diffusion imaging of acute axonal damage in the cerebral peduncle following hypoxia-ischemia in neonatal rats. Pediatr Res. 2013;73(3):325-31. 142. Tan MA, Miller E, Shroff MM, Deveber GA, Kirton A. Alleviation of neonatal sinovenous compression to enhance cerebral venous blood flow. J Child Neurol. 2013;28(5):583-8.

143. Yang JF, Livingstone D, Brunton K, Kim D, Lopetinsky B, Roy F, Zewdie E, Patrick SK, Andersen J, Kirton A, Watt JM, Yager J, Gorassini M. Training to enhance walking in children with cerebral palsy: are we missing the window of opportunity? Semin Pediatr Neurol. 2013;20(2):106-15. 144. Kirton A, Holland M, Sebire G, Armstrong D, Hawkins C, Wade A, deVeber G. Childhood stroke and fibromuscular dysplasia. Brain 2013;136:1846-56. epub May 28. 145. Kirton A. Modeling developmental plasticity after perinatal stroke: Defining central therapeutic targets in cerebral palsy. Ped Neurol 2013;48(2):81-94. 146. Rajapakse T, Kirton A. Emerging applications of non-invasive brain stimulation in children. Translational Neurosci 2013;4(2):217-233. 147. Tuor UI, Qiao M, Morgunov M, Fullerton E, Kirton A. Magnetization transfer imaging of acute axonal degeneration following unilateral cerebral hypoxiaischemia in neonatal rats. Ped Res 2013; 73(3):325-31. Epub 2012 Nov 30. 148. Tan M, deVeber G, Miller E, Shroff M, Kirton A.

Alleviation of neonatal cerebral venous obstruction with a customdesigned pillow. J Child Neurol 2013; 28(5):583-8. epub 2012 July 17. 149. Schechter T, Kirton A, Laughlin S, Pontigon A, Finkelstein Y, MacGregor D, Chan A, deVeber G, Brandao L. Safety of anticoagulants in children with arterial ischemic stroke. Blood 2012; 119(4):949-56, epub Dec 7 150. Kirton A, Crone M, Benseler S, Mineyko A, Armstrong D, Wade A, Sebire G, CrousTsanaclis AM, deVeber G.Fibromuscular Dysplasia and Childhood Stroke. Brain. 2013 Jun;136(Pt 6):1846-56. 151. Picard D, Miller S, Hawkins CE, Bouffet E, Rogers HA, Chan TS, Kim SK, Ra YS, Fangusaro J, Korshunov A, Toledano H, Nakamura H, Hayden JT, Chan J, Lafay-Cousin L, Hu P, Fan X, Muraszko KM, Pomeroy SL, Lau CC, Ng HK, Jones C, Van Meter T, Clifford SC, Eberhart C, Gajjar A, Pfister SM, Grundy RG, Huang A. Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Lancet Oncol Aug;13(8):838-48. 2012.

152. Chaubey V, Davis J, Warren R, Parkins M, Louie M, Gregson D, Sabuda D, Kuhn S. Fever, headache, fatigue, and chancre in a traveler returning from Tanzania. Can J Infect Dis Med Microbiol 2012 Fall;23(3):108-9. 153. Johannes C, Kuhn S, Lemay M, Vanderkooi OG. A 5-year-old boy with fever after a trip to Venezuela (Salmonella Poona Case Report). Pediatrics and Child Health 2013;18(4):197-8. 154. Singh G, Wei XC, Hader W, Chan JA, Bouffet E, Lafay-Cousin L. Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome. J Pediatr Hematol Oncol Mar;35(2):e53-6. 2013. 155. Lafay-Cousin L, Purdy E, Huang A, Cushing SL, Papaioannou V, NettelAguirre A, Bouffet E. Early cisplatin induced ototoxicity profile may predict the need for hearing support in children with medulloblastoma. Pediatr Blood Cancer. 2013 Feb;60(2):287-92. 156. Lafay-Cousin L, Hader W, Wei X, Nordal R, Strother D, Hawkins C, Chan J. Post-chemotherapy

Department of Paediatrics | Annual Report 2013

maturation in supratentorial primitive neuroectodermal tumors. Brain Pathol. 2013 Aug 30. [Epub ahead of print] 157. Singh G, Wei XC, Hader W, Chan JA, Bouffet E, LafayCousin L. J Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome. Pediatr Hematol Oncol. 2013 Mar;35(2):e53-6. 158. Branson LJ, Latter J, Currie G, Nettel-Aguirre A, Embree T, Hagel BE. The effect of surfacing and season on playground injury rates. Paediatrics & Child Health 2012;17(9) 485-489. 159. Abdelfatah N, Merner N, Houston J, Benteau T, Griffin A, Doucette L, Stockley T, Lauzon JL, Young TL. (2013) A novel deletion in SMPX causes a rare form of X-linked progressive hearing loss in two families due to a founder effect. Hum Mut Jan;34(1):66-9. 160. Richer J, Nelson TN, Evans J, Armstrong L, Lauzon J, McGillivray B. (2012) CCMG statement on gene patents. Clin Genet Nov;82(5):405-7. White J, Brownell K, Lemay JF, and Lockyer JM. "What

Do They Want Me To Say?" The hidden curriculum at work in the medical school selection process: a qualitative study. BMC Med Educ 2012;12:17. 161. Lemieux L. An approach to teaching interdisciplinary health care to pre-clerkship medical students. Hospital Pediatrics. 2012; 2(3): 179-181. 162. Hospital Pediatrics 2012;2(3):179 -181. 163. Hoy NY, Leung AK, Metelitsa AI, Adams S. New concepts in median nail dystrophy, onychomycosis and hand-foot-and-mouth disease nail pathology. Dermatology 2012; 2012;68163. 164. Hon KL, Leung AK. Neonatal lupus erythematosus. Autoimmune Diseases 2012;2012: 301274. 165. Leung AK, Sauve RS, Marchand V. The ‘picky eater’: the toddler or preschooler who does not eat. Paediatrics and Child Health 2012;17:455-457.

Barankin B. Barrier repair therapy in atopic dermatitis: an overview. American Journal of Clinical Dermatology 2013;14:389-399. 168. Leung AK, Wong AS. Localized acquired hypertrichosis associated with the application of a splint. Case Reports in Pediatrics 2012;2012:592092. 169. Leung AK, Ng J. Generalized lichen nitidus in identical twins. Case Reports in Dermatological Medicine 2012;2012:982084. 170. Hon KL, Leung AK. Chlamydial pneumonitis: a creepy neonatal disease. Case Reports in Pediatrics 2013;2013:549649. 171. Leung AK, Barankin B. Physiological striae atrophicae of adolescence with involvement of the upper back. Case Reports in Pediatrics 2013;2013:386094.

166. Leung AK, Hon KL. Seasonal allergic rhinitis. Recent Patents on Inflammation & Allergy Drug Discovery 2013;7:187-201.

172. Hon KL, Li J, Cheng C, Leung AK. Septicemia in a neonate following therapeutic hypothermia: the literature review of evidence. Case Reports in Pediatrics 2013;2013:514232.

167. Hon KL, Leung AK,

173. Hon KL, Luk DC, Leung

Annual Report 2013 | Department of Paediatrics

AK. Cupping therapy may be harmful for eczema: a Pubmed search. Case Reports in Pediatrics 2013;2013:605829. 174. Hon KL, Cheng J, Chow CM, Cheung HM, Cheung KL, Tam YH, Leung AK. Complications of bezoar in children: What is new? Case Reports in Pediatrics 2013;2013:523569. 175. Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, LeRademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla, M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP. Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. J Clin Oncol May 1;31(13):1669-76. 2013. 176. Dix D, Cellot S, Price V, Gillmeister B, Ethier MC, Johnston DL, Lewis V, Michon B, Mitchell D, Stobart K, Yanofsky R, Portwine C, Silva M, Bowes L, Zelcer S, Brossard J, Traubici J, Allen U, Beyene J, Sung L. Association

between corticosteroids and infection, sepsis, and infectious death in pediatric acute myeloid leukemia (AML): results from the Canadian infections in AML research group. Clin Infect Dis Dec;55(12):1608-14. 2012. 177. Hale GA, Arora M, Ahn KW, He W, Camitta B, Bishop MR, Bitan M, Cairo MS, Chan K, Childs RW, Copelan E, Davies SM, Perez MA, Doyle JJ, Gale RP, Vicent MG, Horn BN, Hussein AA, Jodele S, Kamani NR, Kasow KA, Kletzel M, Lazarus HM, Lewis VA, Myers KC, Olsson R, Pulsipher M, Qayed M, Sanders JE, Shaw PJ, Soni S, Stiff PJ, Stadtmauer EA, Ueno NT, Wall DA, Grupp SA. Allogeneic hematopoietic cell transplantation for neuroblastoma: the CIBMTR experience. Bone Marrow Transplant. 2013;48(8):1056-64. 178. Luca P, Hamilton J, Mahmud FH, Usher-Smith J. Ask the Experts: Paediatric Type 1 diabetes: adjunctive therapies, celiac disease and the role of the primary care physician. Diabetes Management. 2012; 2:489495. 179. Luca P, Chan M, Basak S, Segal A, Porepa M, Pinard M, Au, H and Birken C. A

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Qualitative Description of the Development and Evaluation of “Our Voice”, a Health Promotion Magazine Created by Paediatric Patients for Hospitalized Paediatric Patients. Hospital Paediatrics. 2013;3:59-64. 180. Luca P*, Oren A*, Somers G and Urbach S. The Search For Ectopic ACTH Production In A 9 Year Old Boy. Journal of Paediatric Endocrinology and Metabolism, 2013;26(78):781-783. *Contributed equally 181. Jayanthan A, Cooper TM, Hoeksema KA, Lotfi S, Woldum E, Lewis VA, Narendran A. Occurrence and modulation of therapeutic targets of Aurora kinase inhibition in pediatric acute leukemia cells. Leuk Lymphoma Jul;54(7):1505-16. 2013. 182. Portwine C, Mitchell D, Johnston D, Gillmeister B, Ethier MC, Yanofsky R, Dix D, Cellot S, Lewis V, Price V, Silva M, ZelcerS, Bowes L, Michon B, Stobart K, Brossard J, Beyene J, Sung L. Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. PLoS One Apr 26;8(4):e61899. 2013. Pound CM, Clark C, Ni A, Athale U, Lewis V, Halton

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JM. Corticosteroids, behavior, and quality of life in children treated for acute lymphoblastic leukemia; a multicentered trial. J Pediatr Hematol Oncol Oct;34(7):517-23. 2012. 183. Price V, Portwine C, Zelcer S, Ethier MC, Gillmeister B, Silva M, Schindera C, Yanofsky R, Mitchell D, Johnston DL, Lewis V, Dix D, Cellot S, Michon B, Bowes L, Stobart K, Brossard J, Beyene J, Sung L. Clostridium difficile Infection in Pediatric Acute Myeloid Leukemia: From The Canadian Infections in Acute Myeloid Leukemia Research Group. Pediatr Infect Dis J Jun;32(6):610613. 2013. 184. Siminoski K, Lee KC, Abish S, Alos N, Bell L, Blydt-Hansen T, Couch R, Cummings EA, Ellsworth J, Feber J, Fernandez CV, Halton J, Huber AM, Israels S, Jurencak R, Lang B, Laverdière C, LeBlanc C, Lewis V, Midgley J, Miettunen PM, Oen K, Phan V, Pinsk M, Rauch F, Rodd C, Roth J, Saint-Cyr C, Scuccimarri R, Stephure D, Taback S, Wilson B, Ward LM; Canadian STOPP Consortium National Pediatric Bone Health Working Group. The development of bone mineral lateralization in

the arms. Osteoporos Int Mar;24(3):999-1006. 2013. 185. Siminoski K, Lee KC, Jen H, Warshawski R, Matzinger MA, Shenouda N, Charron M, Coblentz C, Dubois J, Kloiber R, Nadel H, O'Brien K, Reed M, Sparrow K, Webber C, Lentle B, Ward LM; STOPP Consortium (including Lewis V). Anatomical distribution of vertebral fractures: comparison of pediatric and adult spines. Osteoporos Int Jul;23(7):1999-2008. 2012. 186. Lowry RB, Bedard T, Sibbald B, Harder JR, Trevenen C, Horobec V, Dyck JD. Congenital heart defects and major structural noncardiac anomalies in Alberta, Canada, 1995-2002. Birth Defects Res A Clin Mol Teratol. 2013 Feb;97(2): 79-86. 187. Bedard T, Lowry RB, Sibbald B, Harder JR, Trevenen C, Horobec V, Dyck JD. Congenital heart defect case ascertainment by the Alberta Congenital Anomalies Surveillance System. Birth Defects Res A Clin Mol Teratol. 2012 Jun;94(6):449-58. 188. R Lowry RB, Bedard T, Sibbald B, Harder JR,

189. Trevenen C, Horobec V, and Dyck JD.Congenital Heart Defects and Major Structural Noncardiac Anomalies in Alberta, Canada, 1995–2002. Plastic & Reconstructive Surgery: April 2013 – Volume 131 – Issue 4 – p649e-650e 190. Luca NJ and Yeung RS. Epidemiology and Management of Kawasaki Disease. Drugs. 2012;72(8):1029-38. 191. Luca NJ, Atkinson A, Hawkins C, Feldman BM. A Case of AntiSignal Recognition Particle-Positive Juvenile Polymyositis Successfully Treated with Rituximab. J Rheumatol. 2012 Jul;39(7):1483-5. 192. Luca NJ, Lara-Corrales I, Pope E. Eczema herpeticum in children: clinical features and factors predictive of hospitalization. J Pediatr. 2012 Oct;161(4):671-5. 193. Luca NJ, Feldman BM. Pediatric Rheumatic Disease: Defining clinically inactive disease in juvenile dermatomyositis. Nat Rev Rheumatol. 2012 Oct 2. 194. Stinson JN, Luca NJC, Jibb LA. Assessment and Management of Pain in Juvenile Idiopathic Arthritis. Pain Res Manage. 2012;17(6):391-396.

195. Carrey N, Bernier D, Emms M, Gunde E, Sparkes S, MacMaster FP, Rusak B. Smaller Volumes of Caudate Nuclei in Prepubertal Children with ADHD: Impact of Age. Journal of Psychiatric Research (2012) 46(8): 1066-1072 196. MacMaster FP, Carrey N, Langevin LM. Corpus Callosal Morphology in Early Onset Adolescent Depression. Journal of Affective Disorders (2013) 145 (2): 256-259. 197. Romo-Nava F, Hoogenboom WS, Pelavin PE, Alvarado JL, Bobrow LH, MacMaster FP, Keshavan M, McCarley RW, Shenton ME. Pituitary volume in schizophrenia spectrum disorders. Schizophrenia Research (2013) 146 (1-3): 301-307. 198. Kemp A, MacMaster FP, Jaworska N, Yang XR, Pradhan S, Mahnke D, Courtright A, Goodyear B, Ramasubbu R. Age of Onset and Corpus Callosal Morphology in Depression. Journal of Affective Disorders (2013) 150(2): 703-706. 199. Goia E, Hamilton L, Chan J, Wei XC, Mah JK, Rho JM. Unilateral Foot Drop

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as an Initial Presentation of a Brain Tumor in a Child. J Child Neurol. 2013 Mar 1.[Epub ahead of print] 200. Katz SL, McKim D, Hoey L, Barrowman N, Kherani T, Kovesi T, MacLusky I, Mah JK. Respiratory management strategies for Duchenne muscular dystrophy: practice variation amongst Canadian sub-specialists. Pediatr Pulmonol. 2013 Jan;48(1):59-66. 201. Khan A, Trevenen CL, Wei X-C, Sarnat HB, Payne E, Kirton A. Alpers syndrome: The natural history of a case highlighting neuroimaging, neuropathology, and fat metabolism. J Child Neurol 2012;27:636-640. 202. O'Mahony J, Bar-Or A, Arnold DL, Sadovnick AD, Marrie RA, Banwell B; CanadianPediatric Demyelinating Disease Network.Collaborators: Wambera K, Connolly MB, Yager J, Mah JK, Booth F, Sebire G, CallenD, Meaney B, Dilenge ME, Lortie A, Pohl D, Doja A, Venketeswaran S, Levin S,MacDonald E, Meek D, Wood E, Lowry N, Buckley D, Yim C, Awuku M, Cooper P, Grand'Maison F, Baird J, Bhan V, Reginald A, McGowan M, Verhey L, Arnaoutelis R,Halliday

W, Marin S, Branson H. Masquerades of acquired demyelination in children: experiences of a national demyelinating disease program. J Child Neurol. 2013;28(2):184-97. 203. Sadaka Y, Verhey LH, Shroff MM, Branson HM, Arnold DL, Narayanan S, Sled JG, Bar-Or A, Sadovnick AD, McGowan M, Marrie RA, Banwell B; Canadian Pediatric Demyelinating Disease Network. [Mah, JK] 2010 McDonald criteria for diagnosing pediatric multiple sclerosis. Ann Neurol. 2012;72(2):211-23. 204. Ariane Larouche, Geneviève Gaëtan, Nabil El-Bilali, Mathieu QuesnelVallières, Steven R. Martin, Fernando Alvarez, Naglaa H. Seronegative Hepatitis C Infection in a Child Infected via Mother-to-Child Transmission. Journal of Clinical Microbiology 2012; 50:2515-2519. 205. Myers KA, McLeod DR, Bello-Espinosa L. Infantile ictal apneas in a child with Williams-Beuren syndrome. Pediatr Neurol. 2013;48(2):149-51. 206. Vallerand I, McLennan JD. Child and adolescent mental health service management strategies that may influence wait times. Journal of the

Annual Report 2013 | Department of Paediatrics

Canadian Academy of Child and Adolescent Psychiatry 2013;22(2):159-165. 207. McLennan JD, Doig J, Rasmussen C, Hutcheon E, Urichuk. Stress and relief: parents attending a respite program. Journal of the Canadian Academy of Child and Adolescent Psychiatry 2012;21(4):261-269. 208. Lazarevic D, Pistorio A, Palmisani E, Miettunen P, Ravelli A, Pilkington C, Wulffraat NM, Malattia C, Garay SM, Hofer M, Quartier P, Dolezalova P, Penades IC, Ferriani VP, Ganser G, Kasapcopur O, Melo-Gomes JA, Reed AM, Wierzbowska M, Rider LG, Martini A, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO). The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis. Ann Rheum Dis. 2013 May;72(5):686-93. 209. Siminoski K, Lee KC, Abish S, Alos N, Bell L, Blydt-Hansen T, Couch R, Cummings EA, Ellsworth J, Feber J, Fernandez CV, Halton J, Huber AM, Israels S, Jurencak R, Lang B, Laverdière C, LeBlanc C, Lewis V, Midgley J, Miettunen PM, Oen K, Phan V, Pinsk M, Rauch F, Rodd C, Roth J, Saint-Cyr C, Scuccimarri R, Stephure

D, Taback S, Wilson B, Ward LM Canadian STOPP Consortium National Pediatric Bone Health Working Group. The Development of Bone Mineral Lateralization in the Arms. Osteoporos Int. 2013 Mar;24(3):999-1006. 210. Mineyko A, Kirton A. Mechanisms of pediatric cerebral arteriopathy: an inflammatory debate. Pediatr Neurol. 2013;48(1):14-23. 211. Mineyko A, Kirton A, Ng D, Wei XC. Normal intracranial periarterial enhancement on pediatric brain MR imaging. Neuroradiology. 2013;55(9):1161-9. 212. Mineyko A, Narendran A, Fritzler ML, Wei XC, Schmeling H, Kirton A. Inflammatory biomarkers of pediatric focal cerebral arteriopathy. Neurology 2012;79(13):1406-8. 213. Mineyko A, Wei X, Kirton A. Normal intracranial periarterial enhancement on pediatric brain MR imaging. Neuroradiol 2013, epub Jun 5. 214. Mineyko A, Kirton A. Mechanisms of arteriopathy in childhood stroke: An inflammatory debate. Ped Neurol 2013; 48(1):14-23.

215. Mineyko A, Narendran A, Fritzler ML, Wei X, Schmeling H, Kirton A. Inflammatory biomarkers of pediatric focal cerebral arteriopathy. Neurology 2012; 79:1406-8. epub Aug 22. 216. Leblanc CM, Lang B, Bencivenga A, Chetaille AL, Dancey P, Dent P, Miettunen P, Oen K, Rosenberg A, Roth J, Scuccimarri R, Tse SM, Benseler S, Cabral DA, Campillo S, Chédeville G, Duffy CM, Duffy KW, Haddad E, Huber AM, Laxer R, Levy D, Johnson N, Ramsey S, Shiff N, Schmeling H, Schneider R, Stringer E, Yeung RS, Tucker LB. Access to biologic therapies in Canada for children with juvenile idiopathic arthritis. J Rheumatol. 2012 Sep;39(9):1875-9. 217. Leblanc CM, Lang B, Bencivenga A, Chetaille AL, Dancey P, Dent P, Miettunen P, Oen K, Rosenberg A, Roth J, Scuccimarri R, Tse SM, Benseler S, Cabral DA, Campillo S, Chédeville G, Duffy CM, Duffy KW, Haddad E,Huber AM, Laxer R, Levy D, Johnson N, Ramsey S, Shiff N, Schmeling H, Schneider R, Stringer E, Yeung RS, Tucker LB: Access to biologic therapies in

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Canada for children with juvenile idiopathic arthritis. J Rheumatol 2012; 39(9): 1875-9. 218. Miettunen PM, LafayCousin L, Guilcher GM, Nettel-Aguirre A, Moorjani V. Widespread osteonecrosis in children with leukemia revealed by whole-body MRI.Clin Orthop Relat Res. 2012 Dec;470(12):3587-95. 219. Leblanc CM, Lang B, Bencivenga A, Chetaille AL, Dancey P, Dent P, Miettunen P, Oen K, Rosenberg A, Roth J, Scuccimarri R, Tse SM, Benseler S, Cabral DA, Campillo S, Chédeville G, Duffy CM, Duffy KW, Haddad E, Huber AM, Laxer R, Levy D, Johnson N, Ramsey S, Shiff N, Schmeling H, Schneider R, Stringer E, Yeung RS, Tucker LB. Access to biologic therapies in Canada for children with juvenile idiopathic arthritis. J Rheumatol 2012 Sep;39(9):1875-9 220. Alos N, Grant RM, Ramsay T, Halton J, Cummings EA, Miettunen PM, Abish S, Atkinson S, Barr R, Cabral DA, Cairney E, Couch R, Dix DB, Fernandez CV, Hay J, Israels S, Laverdière C, Lentle B, Lewis V, Matzinger M, Rodd C, Shenouda N, Stein R,

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Stephure D, Taback S, Wilson B, Williams K, Rauch F, Siminoski K, Ward LM. High incidence of vertebral fractures in children with acute lymphoblastic leukemia 12 months after the initiation of therapy. J Clin Oncol. 2012 Aug 1;30(22):2760-7. 221. Shiff NJ, Brant R, Guzman J, Cabral DA, Huber AM, Miettunen P, Roth J, Scuccimarri R, Alos N, Atkinson SA, Collet JP, Couch R, Cummings EA, Dent PB, Ellsworth J, Hay J, Houghton K, Jurencak R, Lang B, Larche M, Leblanc C, Rodd C, Saint-Cyr C, Stein R, Stephure D, Taback S, Rauch F, Ward LM; Canadian Steroidassociated Osteoporosis in the Pediatric Population Consortium. Glucocorticoid-related changes in body mass index among children and adolescents with rheumatic diseases.Arthritis Care Res (Hoboken). 2013 Jan;65(1):113-21. 222. Ortiz-Alvarez O, Mikrogianakis A, (Acute Care Committee) et al. CPS Position Statement: Managing the paediatric patient with an acute asthma exacerbation; Paediatr Child Health 2012;17(5):251-5. (National Guideline)

223. Friedman JN, Mikrogianakis A, (Acute Care Committee) et al. CPS Practice Point: Risk of acute hyponatremia in hospitalized children and youth receiving maintenance intravenous fluids; Paediatr Child Health 2013;18(2):102-104. (National Practice Point) 224. Farrell C, Mikrogianakis A, Cheng A (Acute Care Committee) et al. CPS Position Statement: Management of the Pediatric Patient with Acute Head Trauma. Pediatric Child Health, 2013; 18(5):253-8. C (National Guideline) 225. Mineyko A, Narendran A, Fritzler ML, Wei XC, Schmeling H, Kirton A. Inflammatory biomarkers of pediatric focal cerebral arteriopathy. Neurology 2012; 79(13): 1406-8. 226. Paes B, Mitchell I, Li A, Harimoto T, Lanctôt KL. 227. Respiratory-related hospitalizations following prophylaxis in the Canadian registry for palivizumab (2005-2012) compared to other international registries. 228. Clin Dev Immunol. 2013;2013:917068. doi: 10.1155/2013/917068. Epub 2013 Jun 19.

229. Szabo SM, Levy AR, Gooch KL, Bradt P, Wijaya H, Mitchell I. Elevated risk of asthma after hospitalization for respiratory syncytial virus infection in infancy. 230. Paediatr Respir Rev. 2013 Jan;13 Suppl 2:S9-15. 231. Szabo SM, Gooch KL, Bibby MM, Vo PG, Mitchell I, Bradt P, Levy AR. The risk of mortality among young children hospitalized for severe respiratory syncytial virus infection. 232. Paediatr Respir Rev. 2013 Jan;13 Suppl 2:S1-8. 233. Paes B, Mitchell I, Li A, Lanctôt KL; CARESS Investigators. A comparative study of respiratory syncytial virus (RSV) prophylaxis in premature infants within the Canadian Registry of Palivizumab (CARESS). 234. Eur J Clin Microbiol Infect Dis. 2012 Oct;31(10):270311. Epub 2012 May 1. 235. Manhas KP, Mitchell I. Extremes, uncertainty, and responsibility across boundaries: facets and challenges of the experience of transition to complex, pediatric home care. 236. J Child Health Care. 2012 Sep;16(3):224-36.

237. O'Keefe J, Byrne R, Montgomery M, Harder J, Roberts D, Sigalet DL. Longer term effects of closed repair of pectus excavatum on cardiopulmonary status. J Pediatr Surg. 2013 May;48(5):1049-54 238. Abd Elmoneim A, Gore L, Ricklis RM, Boklan J, Cooper T, Narendran A, Rolla K, Scott T, Arceci RJ. Phase I dose- escalation trial of clofarabine followed by escalating doses of fractionated cyclophosphamide in children with relapsed or refractory acute leukemias. Pediatr Blood Cancer Dec 15;59(7):1252-8. 2012. 239. August KJ, Narendran A, Neville KA. Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions. Drugs Apr;73(5):439-61. 2013. 240. de Oliveira JC, Brassesco MS, Scrideli CA, Tone LG, Narendran A. MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer Oct;59(4):599-604. 2012. 241. Gore L, Trippett TM, Katzenstein HM, Boklan J, Narendran A, Smith

Department of Paediatrics | Annual Report 2013

A, Macy ME, Rolla K; for the Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC), Narashimhan N, Squillace RM, Turner CD, Haluska FG, Nieder M. A Multicenter, Firstin-Pediatrics, Phase 1, Pharmacokinetic and Pharmacodynamic Study of Ridaforolimus in Patients with Refractory Solid Tumors. Clin Cancer Res Jul 1;19(13):3649-3658. 2013.

244. Mineyko A, Narendran A, Fritzler ML, Wei XC, Schmeling H, Kirton A. Inflammatory biomarkers of pediatric focal cerebral arteriopathy. Neurology Sep 25;79(13):1406-8. 2012.

242. Lun X, Ruan Y, Jayanthan A, Liu DJ, Singh A, Trippett T, Bell J, Forsyth P, Johnston RN, Narendran A. Doubledeleted vaccinia virus in virotherapy for refractory and metastatic pediatric solid tumors. Mol Oncol. 2013;7(5):944-54.

246. Sooriyaarachchi M, Narendran A, Gailer J. The effect of sodium thiosulfate on the metabolism of cis-platin in human plasma in vitro. Metallomics Aug 24;4(9):960-7. 2012.

243. Macy ME, Duncan T, Whitlock J, Hunger SP, Boklan J, Narendren A, Herzog C, Arceci RJ, Bagatell R, Trippett T, Christians U, Rolla K, Ivy SP, Gore L; Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC). A multicenter phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors. Pediatr Blood Cancer Feb;60(2):230-6. 2013.

245. Sooriyaarachchi M, Narendran A, Gailer J. N-acetyl-L-cysteine modulates the metabolism of cis-platin in human plasma in vitro. Metallomics Mar;5(3):197207. 2013.

247. Romanow NTR, Couperthwaite A, McCormack GR, NettelAguirre A, Rowe BH, Hagel BE. Assessing inter-rater agreement of environmental audit data in a matched case-control study on bicycling injuries. Injury Prevention. Inj Prev. 201;19(5):336-41. Epub 2013 Jan 30 248. Russell K, Meeuwisse WH; Nettel-Aguirre A, Emery CA, Wishart J, Romanow N, Rowe BH, Goulet C, Hagel BE. Characteristics of injuries sustained by snowboarders in a terrain park. Clinical Journal

Annual Report 2013 | Department of Paediatrics

of Sport Medicine May 2013;23(3):p 172–177 249. Romanow, NTR, Couperthwaite A, McCormack GR, NettelAguirre A, Rowe BH, Hagel, BE. Environmental determinants of bicycling injuries. Journal of Environmental and Public Health, 2012, Epub 2012 Nov 28. 250. Alexander R. Foster B, Tonelli M, Soo A, NettelAguirre A, Hemmelgarn B, Samuel S. Survival and Transplantation Outcomes of Children Less than Two Years of Age with End-Stage Renal Disease. Pediatr Nephrol. 2012 Oct;27(10):1975-83 251. Pacaud D, Kelley H, Downey A, Chiasson M. Successful Delivery of Diabetes Self-Care Education and Follow-Up through eHealth Media Can J Diabetes 36 (5): 257-262, 2012. 252. Wherrett D, Huot C, Pacaud D, Canadian Diabetes Association 2013 Clinical Practice Guidelines Expert Committee. Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada: Type 1 Diabetes in Children and Adolescents. Can J Diabetes, 37 (suppl 1):S153-S162, 2013.

253. Win AK, Walters RJ, Buchanan DD, Jenkins MA, Sweet K, Frankel WL, de la Chappelle A, McKeone DM, Walsh MD, Clendenning M, Pearson SA, Pavluk E, Nagler B, Hopper JL, Gattas MR, Goldblatt J, George J, Suthers GK, Phillips KD, Woodall S, Arnold J, Tucker K, Field M, Greening S, Gallinger S, Aronson M, Perrier R, Woods MO, Green JS, Walker N, Rosty C, Parry S, Young JP. 2012. Cancer risks for relatives of patients with serrated polyposis. Am J Gastroenterol. 107(5); 770-8 254. Gambling in children and adolescents. Gupta R, Pinzon JL, Canadian Paediatric Society, Adolescent Health Committee: Paediatr Child Health 2012;17(5):263-4 255. Pringsheim T , Lam D , Day L , Genge A , Hogan DB , Shevell M , Fortin CM , Maxwell C , Fiebelkorn G , Barlow K , Kapral MK , Casha S , Mobach T, Johnston M , Jette N , Korngut L, "Validation and interpretation of neurological registry data.", The Canadian journal of neurological sciences. 2013; 40(4 Suppl 2) PubMed ID: 23787269 256. Schmidt B, Whyte R.K., Asztalos E.V, Moddemann

D, Poets C, Rabi Y, Solimano A, Roberts R.S, MSc for the Canadian Oxygen Trial (COT) Group. Effects of Targeting Higher vs Lower Arterial Oxygen Saturations on Death or Disability in Extremely Preterm Infants: A Randomized Clinical Trial. JAMA 2013; 309(20): 21112120, PMID 23644995. 257. Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC; Childhood Absence Epilepsy Study Team. [Rho JM] Ethosuximide, valproic acid, andlamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12months. Epilepsia. 2013 Jan;54(1):141-55. 258. Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia. 2012;53(11): 1868-76. 259. Patel M, Rho JM. Sweets Are BAD for Seizures. Epilepsy Curr. 2012;12(6):218-9.. 260. Ruskin DN, Svedova J, Cote JL, Sandau U, Rho JM, Kawamura M Jr, Boison D, Masino SA. Ketogenic diet

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improves core symptoms of autism in BTBR mice. PloS One. 2013;8(6):e65021. 261. Simeone TA, Simeone KA, Samson KK, Kim do Y, Rho JM. Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices. Neurobiol Dis. 2013; 54:68-81. 262. Masino SA, Rho JM. Mechanisms of Ketogenic Diet Action. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, DelgadoEscueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. 263. Rho JM, Zupec-Kania B, Masino SA: Ketogenic Diet and Epilepsy: The Role of Adenosine. In: Adenosine: A Key Link Between Metabolism and Central Nervous System Activity, Masino SA, Boison DEds.), Springer, 2013. 264. Appl Physiol Nutr Metab. 2012 Aug;37(4): 715-23.. 265. An exploratory study of sodium, potassium, and fluid nutrition status of tube-fed nonambulatory

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children with severe cerebral palsy. 266. McGowan JE, Fenton TR, Wade AW, Branton JL, Robertson M. 267. Samuel S, Hemmelgarn B, Nettel-Aguirre A, Foster B, Soo A, Alexander R, Tonelli M. Association Between Residence Locating and Likelihood of Transplantation Among Pediatric Dialysis Patients. Pediatr Transplant. 2012 Nov;16(7):735-41 268. Samuel S, Foster B, Hemmelgarn B, NettelAuirre A, Crowshoe L, Alexader R, Soo A, Tonelli M. Incidence and Causes of End-Stage Renal Disease Among Aboriginal Children and Young Adults. CMAJ. 2012 Oct;184(14):E758-64 269. Alexander R, Hemmelgarn B, Wiebe N, Bello A, Morgan C, Samuel S, Klarenbach S, Curhan G, Tonelli M. Kidney Stones and Kidney Function Loss: A Cohort Study. BMJ. 2012 Aug29;345-:E5287 270. James M, Samuel S, Manning M, Tonelli M, Ghali W, Faris P, Knudtson M, Pannu N, Hemmelgarn B. Contrast-Induced Acute Kidney Injury and Risk of Adverse Clinical Outcomes After Coronary Angiography: A Systematic

Review and Meta-Analysis. Circ Cardiovasc Interv. 2013 Feb1;6(1):37-43 271. James M, Samuel S, Manning M, Tonelli M, Ghali W, Faris P, Knudtson M, Pannu N, Hemmelgarn B. Contrast-Induced Acute Kidney Injury and Risk of Adverse Clinical Outcomes After Coronary Angiography: A Systematic Review and Meta-Analysis. Circ Cardiovasc Interv. 2013 Feb1;6(1):37-43 272. Alexander R. Foster B, Tonelli M, Soo A, NettelAguirre A, Hemmelgarn B, Samuel S. Survival and Transplantation Outcomes of Children Less than Two Years of Age with End-Stage Renal Disease. Pediatr Nephrol. 2012 Oct;27(10):1975-83 273. Samuel S, Foster B, Hemmelgarn B, NettelAuirre A, Crowshoe L, Alexader R, Soo A, Tonelli M. Incidence and Causes of End-Stage Renal Disease Among Aboriginal Children and Young Adults. CMAJ. 2012 Oct;184(14):E758-64 274. Samuel S, Hemmelgarn B, Nettel-Aguirre A, Foster B, Soo A, Alexander R, Tonelli M. Association Between Residence Locating and Likelihood of Transplantation Among Pediatric Dialysis Patients.

Pediatr Transplant. 2012 Nov;16(7):735-41 275. Alexander R, Hemmelgarn B, Wiebe N, Bello A, Morgan C, Samuel S, Klarenbach S, Curhan G, Tonelli M. Kidney Stones and Kidney Function Loss: A Cohort Study. BMJ. 2012 Aug29;345-:E5287 276. Samuel S, Foster B. Reduced Kidney Transplant Survival in Adolescence and Young Adulthood: Is it Due to Age, Transfer of Care or both? American Society of Nephrology Kidney News, September 2012 277. N Sandhu, D Thomson, A Stang. In children with chronic suppurative otitis media, should one prescribe topical or systemic antibiotics. Evidence for Clinicians. Pediatrics and Child Health 2012;17(7): 385-386. 278. Sandhu N, Eppich W, Mikrogianakis A, Grant V, Robinson T, Cheng A The Canadian Pediatric Simulation Network (CPSN) Debriefing Consensus Group. Postresuscitation debriefing in the pediatric emergency department: A national needsassessment. CJEM 2013;15(0):1-10.

279. De Lonlay P, Rötig A, Sarnat HB. Respiratory chain deficiencies. In: Dulac O, Lassonde M, Sarnat HB, editors. Elsevier Handbook of Clinical Neurology: Paediatric Neurology (Vols. 111 and 112, 3rd series). Edinburgh, London, NY, Toronto: Elsevier. 2013;113:1651-1666. 280. Dulac O, Lassonde M, Sarnat HB, editors. Elsevier Handbook of Clinical Neurology: Paediatric Neurology (Vols. 111, 112 and 113, 3rd series). Edinburgh, London, NY, Toronto: Elsevier. 2013 281. Flores-Sarnat L. Neurocutaneous melanocytosis. Handb Clin Neurol. 2013;111:369-88. 282. Flores-Sarnat L. Congenital infiltrating lipomatosis of the face: recognition and pathogenesis. Neuropediatrics. 2012 Dec;43(6):346-8. 283. Prabowo A, Anink J, Lammens M, Nellist M, van den Ouweland AMW, Adle-Biassette H, Sarnat HB, Flores-Sarnat L, Crino PB, Aronica E. Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation. Brain Pathol 2013;23:45-59.

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284. Rubens D, Sarnat HB. Sudden infant death syndrome: an update and new perspectives of etiology. In: Dulac O, Lassonde M, Sarnat HB, editors. Elsevier Handbook of Clinical Neurology: Paediatric Neurology (Vols. 111, 112 and 113, 3rd series). Edinburgh, London, NY, Toronto: Elsevier. 2012;112: 867-874. 285. Sarnat HB, Flores-Sarnat L, Casey R, Scott P, Khan A. Endothelial ultrastructural alterations of intramuscular capillaries in infantile mitochondrial cytopathies . Neuropathology 2012;32:617-627. 286. Sarnat HB, FloresSarnat L, Crino PB, Hader W, Bello-Espinosa L. Hemimegalencephaly: fetal tauopathy, mTOR activation and neuronal lipidosis. Folia Neuropathol. 2012:50:330345. 287. Sarnat HB, Auer RN, Flores-Sarnat L. Synaptogenesis in the fetal corpus striatum, globus pallidus and substantia nigra. Correlations with striosomes of Graybiel and dyskinesias in premature infants. J Child Neurol 2013;28:60-69. 288. Sarnat HB, Flores-Sarnat L. Radial micro-columnar cortical architecture:

maturational arrest or focal cortical dysplasia? Pediatr Neurol 2013;48: 259-270. 289. Sarnat HB, Flores-Sarnat L. Precocious and delayed neocortical synaptogenesis in fœtal holoprosencephaly. Clin Neuropathol. 2013;32:255-268. 290. Sarnat HB, Flores-Sarnat L, Pinter JD. Chapter 4. Neuroembryology. In: Youman’s Neurological Surgery, 6th ed., Winn HR, editor. Philadelphia: Saunders-Elsevier. 2012; pp 78-97. Supplementary references e10-e14. 291. Sarnat HB, Flores-Sarnat L. Developmental disorders of the nervous system. In: Bradley’s Neurology in Clinical Practice, 6th ed., Daroff RB, Fenichel G, Jankovic J, Mazziotta J, editors. Philadelphia: Elsevier/Saunders. Chapter 60, 2012; vol. 2, pp 13961421. 292. Sarnat HB, Flores-Sarnat L. Neuroembryology and brain malformations: an overview. In: Dulac O, Lassonde M, Sarnat HB, editors. Elsevier Handbook of Clinical Neurology: Paediatric Neurology (Vols. 111, 112 and 113, 3rd series). Edinburgh, London, NY, Toronto: Elsevier. 2013;111:117-128.

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293. Sarnat HB, Flores-Sarnat L. Genetics of neural crest and neurocutaneous syndromes. In: Dulac O, Lassonde M, Sarnat HB, editors. Elsevier Handbook of Clinical Neurology: Paediatric Neurology (Vols. 111 and 112, 3rd series). Edinburgh, London, NY, Toronto: Elsevier. 2013;111:309-314. 294. Sarnat HB, Flores-Sarnat L. Neuropathology of paediatric epilepsy. In: Dulac O, Lassonde M, Sarnat HB, editors. Elsevier Handbook of Clinical Neurology: Paediatric Neurology (Vols. 111 and 112, 3rd series). Edinburgh, London, NY, Toronto: Elsevier. 2013;111:399-416. 295. Huber AM, Robinson AB, Reed AM, Abramson L, Bout-Tabaku S, Carrasco R, Curran M, Feldman BM, Gewanter H, Griffin T, Haines K, Hoeltzel MF, Isgro J, Kahn P, Lang B, Lawler P, Shaham B, Schmeling H, Scuccimarri R, Shishov M, Stringer E, Wohrley J, Ilowite NT, Wallace C. Consensus treatments for moderate juvenile dermatomyositis: Beyond the first two months. Arthritis Care Res (Hoboken) 2012; 64(4): 546-53. 296. Johnson K, Stang AS, Johnson DW, Rowe BH,

Hartling L. Different systemic corticosteroid regimens for the emergency management of acute asthma (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.: CD009635. DOI: 10.1002/14651858. CD009635. 297. Wong T, Johnson DW, Ganshorn H, Maconochie IK, Hartling L, Stang AS. Combined and alternating paracetamol and ibuprofen therapy for fever in children (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD009572. 298. Al-Wassia H, Alshaikh B, Sauve R. Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review and meta-analysis. J Perinatol. 2013 Apr;33(4):271-7. 299. Al-Mandeel H, Alhindi MY, Sauve R. Effects of intentional delivery on maternal and neonatal outcomes in pregnancies with preterm prelabour rupture of membranes between 28 and 34 weeks of gestation: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2013 Jan; 26(1):83-9.

300. Fenton TR, Nasser R, Eliasziw M, Kim J, Bilan D, Sauve R. Validating the weight gain of preterm infants between the reference growth curve fetus and the term infant. BMC Pediatrics. 2013 June; 13(1): 92. 301. Liu S, Joseph KS, Lisonkova S, Rouleau J, Van den Hof M, Sauve R, Kramer M. Association between maternal chronic conditions and congenital heart defects: A population-based cohort study. Circulation. 2013; 128:583-589. 302. Liu S, Joseph KS, Lisonkova S, Rouleau J, Van den Hof M, Sauve R, Kramer M. Association between maternal chronic conditions and congenital heart defects: A population-based cohort study. Circulation. 2013; 128:583-589. 303. Morgan CJ, Zappitelli M, Robertson CM, Alton GY, Sauve RS, Joffe AR, Ross DB, Rebeyka IM; Western Canadian Complex Pediatric Therapies FollowUp Group. Risk factors for and outcomes of acute kidney injury in neonates undergoing complex cardiac surgery. J Pediatr. 2013 Jan;162(1):120-7.e1. 304. Ross S, Wood S, Tang S, Miller L, Sauve R, Brant R. Vaginal progesterone

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to prevent preterm birth in multiple pregnancy: A Randomized Controlled trial. J Perinatal Med. Jul 2012; 40: 593-599. 305. Goudar SS, Somannavar MS, Clark R, Lockyer JM, Revankar AP, Fidler HM, Sloan NL, Niermeyer S, Keenan WJ, Singhal N. Stillbirth and newborn mortality in India after helping babies breathe training. Pediatrics. 2013 Feb; 131(2):e344-52. 306. Plakkal N, Soraisham AS, Trevenen C, Freiheit EA, Sauve R. Histological Chorioamnionitis and bronchopulmonary Dysplasia: A Cohort Study. J Perinatol. 2013 Jun; 33(6):441-5. 307. Sivanandan S. Soraisham AS, Vali B, Kamaluddeen M, Harabor A. Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. American Journal of Perinatology, 2013 Oct;30(9):745-50. Epub 2013, January 1 308. Soraisham AS, Trevenen C, Wood S, Singhal N, Sauve R. Histological chorioamnionitis and neurodevelopmental outcome in preterm infants. J Perinatol. 2013 Jan; 33(1):70-5.

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309. Steele M, Narendran A. Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL). Ann Hematol Oct;91(10):1513-8. 2012. 310. Rodd C, Lang B, Ramsay T, Alos N, Huber AM, Cabral DA, Scuccimarri R, Miettunen PM, Roth J, Atkinson SA, Couch R, Cummings EA, Dent PB, Ellsworth J, Hay J, Houghton K, Jurencak R, Larche M, LeBlanc C, Oen K, Saint-Cyr C, Stein R, Stephure D, Taback S, Lentle B, Matzinger M, Shenouda N, Moher D, Rauch F, Siminoski K, Ward LM and the Canadian STOPP Consortium. Incident Vertebral Fractures among Children with Rheumatic Disorders 12 Months After Glucocorticoid Initiation: a National Observational Study. Arthritis Care & Research 64(1):122-31, 2012. 311. Alos N, Grant RM, Ramsay T, Halton J, Cummings EA, Miettunen PM, Abish S, Atkinson S, Barr R, Cabral DA, Cairney E, Couch R, Dix DB, Fernandez CV, Hay J, Israels S, Laverdière C, Lentle B, Lewis V, Matzinger M, Rodd C, Shenouda N, Stein R, Stephure D, Taback S, Wilson B, Williams K, Rauch F, Siminoski K, and Ward LM. “High Incidence

of Vertebral Fractures in Children with Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy”. J Clin Oncol 30(22):2760-2767, 2012. 312. Siminoski K, Lee KC, Abish S, Alos N, Bell L, Blydt-Hansen T, Couch R, Cummings EA, Ellsworth J, Feber J, Fernandez CV, Halton J, Huber AM, Israels R, Jurencak B, Lang B, Laverdière C, LeBlanc C, Lewis V, Midgley J, Miettunen PM, Oen K, Phan V, Pinsk M, Rauch F, Rodd C, Roth J, Saint-Cyr C, Scuccimarri R, Stephure D, Taback S, Wilson B, Ward LM, and the Canadian STOPP Consortium (National Pediatric Bone Health Working Group). “The Development of Bone Mineral Lateralization in the Arms”. Osteoporosis Int June 29, 2012. 313. Shiff NJ, Brant R, Guzman J, Cabral DA, Huber AM, Miettunen P, Roth J, Scuccimarri R, Alos N, Atkinson SA, Collett JP, Couch R, Cummings EA, Dent PB, Ellsworth J, Hay J, Houghton K, Jurencak R, Lang B, Larche M, Leblanc C, Rodd C, Saint-Cyr C, Stein R, Stephure D, Taback S, Rauch F, Ward LM and the Canadian STOPP Consortium. “Glucocorticoid-related changes in body mass

index among children and adolescents with rheumatic diseases”. Arthritis Care Res (Hoboken) 65(1):113-21, 2013 January. 314. Stritzke AI, Smyth J, Synnes A, Lee SK, Shah PS. Transfusion associated necrotizing enterocolitis in neonates. Arch Dis Child Fetal Neonatal Ed. 2013 Jan;98(1):F10-4. 315. Stritzke AI, Eng PA. Age-dependent sting recurrence and outcome in immunotherapy treated children with anaphylaxis to Hymenoptera venom. Clinical and Experimental Allergy, 2013 (43), 950-955 316. Ashley DM, Merchant TE, Strother D, Zhou T, Duffner P, Burger PC, Miller DC, Lyon N, Bonner MJ, Msall M, Buxton A, Geyer R, Kun LE, Coleman L, Pollack IF. Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children’s Oncology Group study P9934. J Clin Oncol. Sep 10;30(26):3181-6. 2012. 317. Law N, Greenberg M, Bouffet E, Taylor MD, Laughlin S, Strother D, Fryer C, McConnell D, Hukin J, Kaise C, Wang F, Mabbott DJ. Clinical and neuroanatomical predictors of cerebellar mutism

syndrome. Neuro Oncol. 201214(10):1294-303. 318. Halton JM, Hand J, Byron P, Strother D, Blanchette V; C17 Council of Canadian Pediatric Hematology Oncology, Transplantation Directors. Establishing physician to patient ratios and predicting workforce needs for Canadian pediatric hematologyoncology programs. Pediatr Blood Cancer. 2013;60(4):564-9. 319. McLaughlin K, Veale P, McIlwrick J, de Groot J, Wright B. A practical approach to mentoring students with repeated performance deficiencies. BMC Medical Education 2013;13:56. 320. Singh A, Lun X, Jayanthan A, Obaid H, Ruan Y, Strother D, Chi SN, Smith A, Forsyth P, Narendran A. Profiling pathway- specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR- ErbB2 signaling with lapatinib. Mol Oncol Jun;7(3):497-512. 2013. 321. Thull-Freedman J. Of 3700 children thought to have non-cardiac chest pain at initial paediatric cardiology

Department of Paediatrics | Annual Report 2013

clinic evaluation, none suffered cardiac death over a median of 4 years followup. Evid Based Med. 2012 Dec;17(6):190-1. 322. Toulany A, McQuillan R, Thull-Freedman JD and Margolis PA. QuasiExperimental designs for quality improvement research. Implementation Science 2013, 8(Suppl 1):S3. 323. Freedman SB, ThullFreedman JD, Rumantir M, Atenafu E, Stephens D. Emergency Department Revisits in Children With Gastroenteritis: a Retrospective Observational Cohort Study. Journal of Pediatric Gastroenterology & Nutrition 2013 Jun 30. [Epub ahead of print]. 324. Eltorki M, Uleryk E, Freedman SB. Waiver of Informed Consent in Pediatric Resuscitation Research – A Systematic Review. Academic Emergency Medicine 2013;20:822-834. 325. Bhutta ZA, Zapursky A, Wazny K, Levine MM, Black RE, Bassani D, Santosham M, Freedman SB, et al. Setting priorities for development of emerging interventions against childhood diarrhoea. Journal of Global Health 2013 Jun;3(1):10302.

326. Freedman SB, Ali S, Oleszczuk M, Gouin S, Hartling L. Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries. Evidence-Based Child Health: A Cochrane Review Journal 2013 8; 1123-1137. 327. Freedman SB, Geary DF. Bolus fluid therapy and sodium homeostasis in paediatric gastroenteritis. Journal of Paediatrics and Child Health 2013 Mar;49(3):215-22. 328. Kharbanda A, Hall M, Shah S, Freedman SB, Mistry R, Macias C, Bonsu B, Dayan P, Alessandrini E, Neuman M. Variation in Resource Utilization Across a National Sample of Pediatric Emergency Departments. Journal of Pediatrics 2013; Jul;163(1):230-6. 329. Kinlin LM, Bahm A, Guttmann A, Freedman SB. A Survey of Emergency Department Resources and Strategies Employed in the Treatment of Pediatric Gastroenteritis. Academic Emergency Medicine. 2013;20:361-366. 330. Freedman SB, Keating LE, Rumatir M, Schuh S. Healthcare Provider and

Annual Report 2013 | Department of Paediatrics

Caregiver Preferences Regarding Nasogastric and Intravenous Rehydration. Pediatrics 2012; 130(6):e1504-11. 331. Anupam B. Kharbanda, MD, MSc; Nanette C. Dudley, MD; Lalit Bajaj, MD, MPH; Michelle D. Stevenson, MD, MS; Charles G. Macias, MD, MPH; Manoj K. Mittal, et al. (incl Freedman SB). Validation and Refinement of a Prediction Rule to Identify Children at Low Risk for Acute Appendicitis. Arch Pediatr Adolesc Med. 2012;166(8):738-744. 332. Schuh S, Zemek R, Plint A, Black K, Freedman SB, Porter R, Gouin S, Johnson D. Practice Patterns in Asthma Discharge Pharmacotherapy in Pediatric Emergency Departments: Pediatric Emergency Research Canada Study. 2012 Sep;19(9):E1019-26. Academic Emergency Medicine. 333. Glatstein M, Rozen R, Scolnik D, Rimon A, Grisaru-Soen G, Freedman SB, Reif S. Radiologic Predictors of Hyponatremia in Children Hospitalized with Community Acquired Pneumonia. Pediatric Emergency Care 2012; 28(8):764-766. 334. Schuh S, Zemek R, Plint

A, Black K, Freedman S, Porter R, Gouin S, Hernandez A, Johnson D. Magnesium Use in Asthma Pharmacotherapy: A Pediatric Emergency Research Canada Study. Pediatrics 2012; 129(5): 852-9. 335. Freedman SB, Stewart C, Rumantir M, ThullFreedman JD. Predictors of Clinically Significant Upper Gastrointestinal Hemorrhage amongst Children with Hematemesis Presenting to an Emergency Department. Journal of Pediatric Gastroenterology, Hepatology and Nutrition 2012; 54(6):737-43. 336. Kinlin L, Freedman SB. Evaluation of a Clinical Dehydration Scale in Children Requiring Intravenous Rehydration. Pediatrics. 2012; 129(5):e1211-9. 337. Freedman SB, Tung C, Cho D, Rumantir M, Chan KJ. Time Series Analysis of Ondansetron use in Pediatric Gastroenteritis. Journal of Pediatric Gastroenterology, and Nutrition 2012; 54 (3): 381-386 338. Leishmania in HLH: a rare finding with significant treatment implications. Singh G, Shabani-Rad

MT, Vanderkooi OG, Vayalumkal JV, Kuhn SM, Guilcher GM, Steele M.J Pediatr Hematol Oncol. 2013 Apr;35(3):e127-9. 339. Beran T, Ramirez-Serrano A, Vanderkooi O, Kuhn S. Reducing children's pain and distress towards flu vaccinations: a novel and effective application of humanoid robotics. Vaccine 2013; 31(25):2772-7. 340. Deutschmann MW, Livingstone D, Cho JJ, Vanderkooi OG, Brookes JT. The Significance of Streptococcus anginosus Group in Intracranial Complications of Pediatric Rhinosinusitis. JAMA Otolaryngology - Head & Neck Surgery 2013;139(2):157-60. 341. L angley JM, Vanderkooi OG, Garfield HA, Hebert J, Chandrasekaran V, Jain VK, Fries L. Immunogenicity and Safety of Two Dose Levels of a ThimerosalFree Trivalent Seasonal Influenza Vaccine in Children 6-35 Months of Age: A Randomized, Controlled Trial. Journal of the Pediatric Infectious Diseases Society 2012;1(1):55-63. 342. Leal J, Vanderkooi OG, Church DL, MacDonald

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J, Tyrrell GJ, Kellner JD. Eradication of Invasive Pneumococcal Disease (IPD) due to the 7-valent Pneumococcal Conjugate Vaccine (PCV7) Serotypes in Calgary, Alberta. Pediatr Infect Dis J. 2012 Sep;31(9):e169-75 343. Singh G, Shabani-Rad MT, Vanderkooi OG, Vayalumkal JV, Kuhn SM, Guilcher GM, Steele M. Leishmania in HLH: a rare finding with significant treatment implications. J Pediatr Hematol Oncol Apr;35(3):e127-9. 2013. 344. Scheifele DW, Ward BJ, Dionne M, Vanderkooi O, Loeb M, Colman B, PHAC/CIHR Influenza Research Network (PCIRN). Compatibility of AS03-adjuvanted H1N1pdm09 and Seasonal Trivalent Influenza Vaccines in Adults: Results of a Randomized Controlled Trial. Vaccine. 2012;30:4728-32. 345. Scheifele DW, Dionne M, Ward BJ, Cooper C, Vanderkooi OG, Li Y, Halperin SA PHAC/ CIHR Influenza Research Network (PCIRN) (Kellner JD, member). Safety and Immunogenicity of 2010-2011 A/ H1N1pdm09-containing Trivalent Inactivated

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Influenza Vaccine in Adults Previously Given AS03-adjuvanted H1N1 2009 Pandemic Vaccine: Results of a Randomized Trial. Human Vaccines & Immunotherapeutics 2013;9(1):136-43. 346. Singh G, Shabani-Rad MT, Vanderkooi OG, Vayalumkal JV, Kuhn SM, Guilcher GM, Steele M. Leishmania in HLH- A rare finding with significant treatment implications. Journal of Pediatric Hematology Oncology . 2013 Apr;35(3): e127-9. 347. Vayalumkal JV, Suh KN, Toye B, Ramotar K, Saginur R, Roth VR. Â Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA): an affliction of the underclass. Can J Emerg Med 2012 Nov;14(6): 335-43. 348. National surveillance of methicillin-resistant Staphylococcus aureus among hospitalized pediatric patients in Canadian acute care facilities, 19952007.Â Matlow A, Forgie S, Pelude L, Embree J, Gravel D, Langley JM, Saux NL, Moore D, Mounchili A, Mulvey M, Shurgold J, Simor AE, Thomas E,

Vayalumkal J; Canadian Nosocomial Infection Surveillance Program. Pediatr Infect Dis J. 2012 Aug;31(8):814-20. 349. Matlow A, Forgie S, Pelude L, Embree J, Gravel D, Langley JM, Saux NL, Moore D, Mounchili A, Mulvey M, Shurgold J, Simor AE, Thomas E, Vayalumkal J; Canadian Nosocomial Infection Surveillance Program. National surveillance of methicillin-resistant Staphylococcus aureus among hospitalized pediatric patients in Canadian acute care facilities, 1995-2007. Pediatr Infect Dis J. 2012 Aug;31(8):814-20. 350. Mataseje LF, Bryce E, Roscoe D, Boyd DA, Embree J, Gravel D, Katz K, Kibsey P, Kuhn M, Mounchili A, Simor A, Taylor G, Thomas E, Turgeon N, Mulvey MR; Canadian Nosocomial Infection Surveillance Program (Vayalumkal J - Member). Carbapenemresistant Gram-negative bacilli in Canada 2009-10: results from the Canadian Nosocomial Infection Surveillance Program (CNISP). J Antimicrob Chemother. 2012 Jun;67(6):1359-67.

351. McCracken M, Wong A, Mitchell R, Gravel D, Conly J, Embil J, Johnston L, Matlow A, Ormiston D, Simor AE, Smith S, Du T, Hizon R, Mulvey MR; Canadian Nosocomial Infection Surveillance Program (Vayalumkal J - Member). Molecular epidemiology of vancomycin-resistant enterococcal bacteraemia: results from the Canadian Nosocomial Infection Surveillance Program, 1999-2009. J Antimicrob Chemother. 2013 Jul;68(7):1505-9. 352. Rutledge-Taylor K, Matlow A, Gravel D, Embree J, Le Saux N, Johnston L, Suh K, Embil J, Henderson E, John M, Roth V, Wong A, Shurgold J, Taylor G; Canadian Nosocomial Infection Surveillance Program(Vayalumkal J - Member). A point prevalence survey of health care-associated infections in Canadian pediatric inpatients. Am J Infect Control. 2012 Aug;40(6):491-6. 353. Vayalumkal JV, Suh KN, Toye B, Ramotar K, Saginur R, Roth VR. Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA): an affliction of the

underclass. CJEM. 2012 Nov;14(6):335-43. 354. Smith FG, Wade AW, Lewis ML, Qi W. Cyclooxygenase (COX) inhibitors and the newborn kidney. Pharmaceuticals 2012; 5(11):1160-1176. 355. McGowan JE, Fenton TR, Wade AW, Branton JL, Robertson M. An Exploratory Study of Sodium, Potassium, and Fluid Nutrition Status of Tube-Fed Nonambulatory Children with Severe Cerebral Palsy. Appl Physiol Nutr Metab. 2012 Aug;37(4):715-23. 356. VK Sharma, FO Fraulin, D Dumestre, L Walker, AR Harrop. B-blockers for the Treatment of Problematic Hemangiomas 357. Canadian Journal of Plastic Surgery - Volume 21 Issue 1 March 2013-12-10 358. Yeung AK, Di Lorenzo C. Primary Gastrointestinal Motility Disorders in Childhood. Minerva Pediatr. 2012 Dec; 64(6):567-84. 359. Al-Shaikh, B, Yusuf, K, Sauve R. Neurodevelopmental outcomes of very low birth weight infants with neonatal sepsis: systematic

Department of Paediatrics | Annual Report 2013

review and meta-analysis. J Perinatol. 2013 Jul;33(7):558-64. 360. Suksumek N, Scott JN, Chadha R, Yusuf K. “Intraventricular hemorrhage and multiple intracranial cysts associated with congenital cytomegalovirus infection.” J Clin Microbiol 2013 Jul; 51(7):2466-8. Epub 2013 May 15 361. Zemek R , Osmond MH , Barrowman N ,Pediatric Emergency Research Canada (PERC) Concussion Team (Barlow K, Freedman S, Mikrogianakis A, members)Predicting and preventing postconcussive problems in paediatrics (5P) study: protocol for a prospective multicenter clinical prediction rule derivation study in children with concussion.", 2013 BMJ open, 3(8), PubMed ID: 23906960 362. Neveling K, MartinezCarrera LA,Holker I, Heister A, Verrips A, HosseiniBarkooie SM, Gilissen C, Vermeer S, Pennings M, Meijer R, Riele M, Frijns CJ, Suchowersky O,MacLaren L, Rudnik-Schoneborn S, Sinke RJ, Zerres K, Lowry RB, Lemmink HH, Garbes L, Veltman JA, Schelhaas HJ, Scheffer H, Wirth B.Mutations in

BICD2, which Encodes a Golgin and Important Motor Adaptor, Cause Congenital AutosomalDominant Spinal Muscular Atrophy. Am J Hum Genet 2013;92(6):946-54. 363. Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Nageeb M; Finding of Rare Disease Genes (FORGE) Canada Consortium (Bernier F, member), Poulter JA, Mohamed MD, Jafri H, Rashid Y, Taylor GR, Keser V, Mardon G, Xu H, Inglehearn CF, Fu Q, Toomes C, Chen R. Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet. 2012;44(9):1035-9. 364. Fernandez BA, Green JS, Bursey F, Barrett B, MacMillan A, McColl S, Fernandez S, Rahman P, Mahoney K, Pereira SL, Scherer SW, Boycott KM, Woods MO; Finding of Rare Disease Genes (FORGE) Canada Consortium (Bernier F, member),. Adult siblings with homozygous G6PC3 mutations expand

Annual Report 2013 | Department of Paediatrics

our understanding of the severe congenital neutropenia type 4 (SCN4) phenotype. BMC Med Genet. 2012 Nov 21;13:111. 365. Nucci AM, Becker DJ, Virtanen SM, Cuthbertson D, Softness B, Huot C, Wasikowa R, Dosch HM, Akerblom HK, Knip M; TRIGR Study Group (Pacaud D, member). Growth differences between North American and European children at risk for type 1 diabetes. Pediatr Diabetes. 2012 Aug;13(5):425-31. 366. Lo W, Ichord R, Dowling M, Rafay M, Templeton J, Halperin A, Smith S, Licht D, Moharir M, Askalan R, deVeber G for the International Pediatric Stroke Study Group (Kirton A, member). The Pediatric Stroke Recurrence and Recovery Questionnaire: Validation in a prospective cohort." Neurology 2012, 28;79:864-70. Epub Aug 15 367. Dowling M, Hynan L, Lo W, Licht D, McClure C, Yager J, Dlamini N, Kirkham F, deVeber G, Pavlakis S for the International Pediatric Stroke Study Group (Kirton A, member). International Paediatric Stroke Study: stroke associated with

cardiac disorders. Int J Stroke 2013;8 Suppl A100:39-44. Fajardo CA, Gonzalez S, Zambosco G, Cancela MJ, Forero LV, Venegas M, Baquero H, Lemus-Varela L, Kattan J, Wormald F, Sola A, Lantos J. End of life, death and dying in neonatal intensive care units in Latin America. Acta Paediatrica. 2012 Jun;101(6):609-13.

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Acknowledgements The Department of Paediatrics gratefully acknowledges and thanks the following persons and groups for their contributions to this report Dr. Valerie Kirk Project manager Wilma Olivier-Walden and IMAGINE/XEROX team Creative direction, design and print production Nick Heazell Annual Report coordination, additional graphics and photography Tracey Boyle Collation of publications and research materials Special thanks also to The Alberta Childrenâ&#x20AC;&#x2122;s Hospital Foundation, Department Administrative staff, Section Chiefs, Department members and Administrative Assistants for their contributions.

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