Polye P ethyylene e glyycol (PEG) Prod P uctss forr Pep ptide Synth S hesiis
PEEG‐Azidess for C Click‐‐Chem mistryy
AGTC B Bioproductss have a wide range of polyethyylene glyco ol (PEG) bassed biochemical reagentts for appliccations in life science, biotechnology and pharmaceuticcal research h. Our productts include m monodisperrsed PEG sppacers, PEGylation, bio otinylation, cross‐linkers for bioconjugation, molecular m se elf‐assemblly alkaneth hiols and others. We have exte ensive experieence in conttract researrch in the aareas of orgganic synthe esis, polymeer synthesis and modificcations, process develo opment. So if you cann not see wha at you are loooking for aask us and we may be able to do it fo or you.
This sub bsection of our main catalogue c ccontains the e listing of our: Click Chemistry Azide Reagents For a revview of PEGyylation :http://en.wikipeedia.org/wiki/PEGylation n Click che emistry was first f fully described by K. Barry Sharpless of The Sc cripps Researrch Institute in 2001 and d describes chemistry c taillored to gene erate substan nces quickly and a reliably b by joining sm mall units tog gether. Click chemistry is not a single specific reacttion, but was meant to m imic nature, which als so generates s substances by joining sm mall modular units. A Click k chemistry rreaction woulld idealy be e modular, wide w in scope, give very hi gh chemical yields with in noffensive by yproducts, be stereosp pecific, physio ologically stab ble; exhibitin ng a large the ermodynamic c driving force e (> 84 kJ/m mol) to favor a reaction with a single re eaction produ uct. The proc cesses must have h simple reaction cond ditions utlisin ng readily ava ailable startin ng materials and a reagents s, it must also o use no solv vent or use a solvent that is benign or easily remov ved (preferab bly water). C Chromatogra aphy should not n be necesssary. Proteins are made fro om repeating g amino acid units, and su ugars are made from repe eating monosac ccharide units s. The connections are ca arbon - hetero o atom bonds s C-X-C rathe er than carbo on carbon b bonds. In add dition, enzym mes ensure th hat chemical processes p can overcome llarge enthalp py hurdles b by a series of reactions ea ach requiring g only a small energy step p. Mimicking nature in org ganic synthesis is essentiall in the discov very of new p pharmaceutic cals given the e large numb ber of possible es. structure Click che emistry has widespread w applications. S Some of them m are: preparrative organicc synthesis of o 1,4-subs stituted triazo oles, modifica ation of peptiide function with w triazoles s, modificatio on of natural products s and pharma aceuticals dru ug discovery macrocy yclizations usiing Cu(I) catalyzed triazo le couplings, modification n of DNA and nucleotides by triazole lligation, suprramolecular chemistry: c ca alixarenes, ro otaxanes, and d catenanes, dendrimer design, c carbohydrate e clusters and d carbohydratte conjugatio on by Cu(1) catalyzed c tria azole ligation reactions s,polymers, material m scien nce, nanotec hnology, and d Bioconjugattion, for exam mple, azidocou umarin. Click che emistry has also a been use ed for selectiv vely labeling biomolecules s within biolo ogical systems. A gorous set off Click rea action that is to be perform med in a livin ng system mu ust meet an even e more rig criteria tthan in an in vitro reaction n. It must be e bioorthogon nal, meaning the reagentss used may not interact with the biolo ogical system m in any way,, nor may the ey be toxic. The T reaction must also oc ccur al pH and at or around bo ody temperatture. Most Click reactions have a high energy conte ent. at neutra The reac ctions are irre eversible and involve carb bon-hetero attom bonding processes. A An example is s the Stauding ger ligation of azides. For a rev view of click chemistry: c htttp://en.wiki pedia.org/wiki/Click_chem mistry
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Email: info@agtcbioproducts.com or Phone us: UK : +44(0) 1482646020 USA : +1 9786575001 Fax: UK : +44 (0) 1482646020 USA : +1‐800‐410‐3599
AGTC Bioproducts Reagents for Peptide Synthesis
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Polyethyelene Glycol Reagents PEG‐Azides for Click‐Chemistry
Name
£
Product Code
H2N‐PEG(12)‐N3,alpha‐Amino‐omega‐azidododecae(ethyleneglycol) Formula: C24H50N4O11 MW: 570.69 CAS No: 749244‐38‐0
£420.00 £1,440.00 £5,100.00
AG‐150‐1081‐1g AG‐150‐1081‐5g AG‐150‐1081‐25g
H2N‐PEG(7)‐N3,alpha‐Amino‐omega‐azidohepta(ethyleneglycol) Formula: C14H30N4O6 MW: 350.42 CAS No: 957486‐82‐7
£420.00 £1,320.00 £4,200.00
AG‐150‐1087‐1gm AG‐150‐1087‐5gm AG‐150‐1087‐25gm
N3‐PEG(8)‐OH,alpha‐Azido‐omega‐hydroxyocta(ethyleneglycol) Formula: C16H33N3O8 MW: 395.45 £360.00 AG‐150‐1088‐1g CAS No: £1,080.00 AG‐150‐1088‐5g MeO‐PEG‐N3,alpha‐Methoxy‐omega‐azidopoly(ethyleneglycol)(PEG‐MW750Dalton) £276.00 AG‐150‐1219‐750DA‐500mg £480.00 AG‐150‐1219‐750DA‐1g £132.00 AG‐150‐1219‐2000DA‐500mg £240.00 AG‐150‐1219‐2000DA‐1g £132.00 AG‐150‐1219‐5000DA‐500mg £240.00 AG‐150‐1219‐5000DA‐1g Formula: MW: 750DA‐20000DA CAS No:
£168.00
AG‐150‐1219‐10000DA‐500mg
£270.00 £168.00 £270.00
AG‐150‐1219‐10000DA‐1g AG‐150‐1219‐20000DA‐500mg AG‐150‐1219‐20000DA‐1g
N3‐PEG(20)‐OH,alpha‐Azido‐omega‐hydroxyicosa(ethyleneglycol) Formula: C40H81N3O20 MW: 924.1 CAS No:
£420.00 £1,170.00
AG‐150‐1220‐1g AG‐150‐1220‐5g
N3‐dPEG(12)‐OH,35‐Azido‐3‐6‐9‐12‐15‐18‐21‐24‐27‐30‐33‐undecaoxapentatriacontan‐1‐ol Formula: C24H49N3O12 MW: 571.66 CAS No:
£420.00 £1,020.00
AG‐150‐1390‐100mg AG‐150‐1390‐1g
N3‐dPEG(12)‐NHS,1‐Azido‐3‐6‐9‐12‐15‐18‐21‐24‐27‐30‐33‐36‐dodecaoxanonatriacontan‐39‐oicacidsuccinimidylester Formula: C31H56N4O16 MW: 740.79 CAS No:
£420.00 £1,260.00
AG‐150‐1395‐100mg AG‐150‐1395‐1g
N3‐dPEG(4)‐NHS,15‐Azido‐4‐7‐10‐13‐tetraoxa‐pentadecanoicacidsuccinimidylester Formula: C15H24N4O8 MW: 388.37 CAS No:
£360.00 £1,200.00
AG‐150‐1400‐100mg AG‐150‐1400‐1g
N3‐dPEG(8)‐NHS,1‐Azido‐3‐6‐9‐12‐15‐18‐21‐24‐octaoxaheptacosan‐27‐oicacidsuccinimidylester Formula: C23H40N4O12 MW: 564.58 CAS No:
£420.00 £1,170.00
AG‐150‐1405‐100mg AG‐150‐1405‐1g
MeO‐dPEG(12)‐N3,37‐Azido‐2‐5‐8‐11‐14‐17‐20‐23‐26‐29‐32‐35‐dodecaoxaheptatriacontane Formula: C25H51N3O12 MW: 585.69 CAS No:
£420.00 £1,020.00
AG‐150‐1660‐100mg AG‐150‐1660‐1g
£330.00 £840.00
AG‐150‐1690‐100mg AG‐150‐1690‐1g
MeO‐dPEG(4)‐N3,13‐Azido‐2‐5‐8‐11‐tetraoxa‐tridecane Formula: C9H19N3O4 MW: 233.26 CAS No:
MeO‐dPEG(8)‐N3,2‐5‐8‐11‐14‐17‐20‐23‐Octaoxapentacosan‐25‐amine Formula: C17H37NO8 MW: 383.48 CAS No:
£360.00 £960.00
AG‐150‐1705‐100mg AG‐150‐1705‐1g
MeO‐dPEG(24)‐N3,alpha‐Methoxy‐omega‐azido‐24(ethyleneglycol) Formula: C49H99N3O24 MW: 1114.34 CAS No:
£420.00 £1,200.00
AG‐150‐1710‐100mg AG‐150‐1710‐1g
N3‐PEG(9)‐COOH,14‐azido‐5‐oxo‐3‐9‐12‐trioxa‐6‐azatetradecan‐1‐oicacid Formula: C22H42N4O12 MW: 554.59 CAS No:
£480.00 £1,620.00
AG‐150‐2015‐1g AG‐150‐2015‐5g
AGTC Bioproducts Reagents for Peptide Synthesis PEG‐Azides for Click‐Chemistry
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Name
£
Product Code
Biotin‐TEG‐ATFBA,Biotin‐triethylenglycol‐(p‐azido‐tetrafluorobenzamide)‐4‐Azido‐2‐3‐5‐6‐tetrafluoro‐N‐(15‐oxo‐19‐(2‐ oxohexahydro‐1H‐thieno[3‐4‐d]imidazol‐4‐yl)‐4‐7‐10‐trioxa‐14‐azanonadecyl)benzamide Formula: C27H37F4N7O6S MW: 663.68 CAS No:
£360.00 £480.00
AG‐150‐2065‐25mg AG‐150‐2065‐100mg
Biotin‐PEG(3+4)‐N3,N‐(1‐azido‐9‐oxo‐3‐6‐14‐17‐20‐pentaoxa‐10‐azatricosan‐23‐yl)‐5‐biotinamide Formula: C31H57N7O10S MW: 719.89 CAS No:
£360.00 £1,330.00
AG‐150‐2140‐100mg AG‐150‐2140‐1g
N3‐PEG(4)‐COOH,15‐Azido‐4‐7‐10‐13‐tetraoxa‐pentadecanoicacid Formula: C11H21N3O6 MW: 291.3 CAS No:
£420.00 £1,125.00
AG‐150‐2345‐100mg AG‐150‐2345‐1g
£390.00 £1,200.00
AG‐150‐2350‐100mg AG‐150‐2350‐1g
H2N‐PEG(8)‐N3,alpha‐Amino‐omega‐azidoocta(ethyleneglycol) Formula: C16H34N4O7 MW: 394.46 CAS No: Propargylamine Formula: C3H5N MW: 55.08 CAS No: 2450‐71‐7
£210.00 £420.00
AG‐150‐2755‐5g AG‐150‐2755‐25g
Contact U Us: UK: AGTTC Bioproductss Ltd Hessle, East Yorkshire,, HU13 9LX Mobile 007712223737, Phone: ++44(0)1482646 6020, 13 Fax: +44((0)148264601 nfo@agtcbiop products.com E‐mail: in ngton MA 018887 USA: AGTC Bioproduccts LLC Wilmin Phone: 99786575001, Fax: 1‐8000‐410‐3599 E‐mail: in nfo@agtcbiop products.com