AHDB ADA 2013 Highlights

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The Peer-Reviewed Forum for Real-World Evidence in Benefit Design ™ For Payers, Purchasers, Policymakers, and Other Healthcare Stakeholders

august 2013 I Vol 6 I SPECIAL ISSUE

Payers’ Perspectives in diabetes Including ADA 2013 Highlights

Highlights from the ADA President’s Research Sessions By Mary Mosley

Look AHEAD: Lifestyle Intervention Cost-Effective in Overweight Patients with Type 2 Diabetes But it fails to reduce the number of CV events By Wayne Kuznar

Chicago, IL—At the 2013 American Diabetes Association (ADA) annual meeting, John E. Anderson, MD, President of Medicine & Science of the ADA, hosted the President’s Oral Research Sessions I and II, one session focused on basic science and the other on clinical and behavioral science. A subcommittee for the ADA’s Program Committee selected the abstracts of the 2 sessions. Commenting on these ses­ sions, Dr Anderson said, “The Presidential Oral Research Sessions highlight the best and most promising research of all the abstracts submitted to the Continued on page 8

SGLT-2 Inhibitors Show Durability in Glycemic Control, Weight-Loss Maintenance Empagliflozin reduces HbA1c, Invokana first in class By Wayne Kuznar Chicago, IL—The new drug class of so­ dium glucose cotransporter (SGLT)-2

inhibitors was the subject of several poster presentations at the 2013 Continued on page 12

Chicago, IL—An intensive lifestyle intervention designed for weight loss had no significant effect on the risk of cardiovascular (CV) events after a dec­ ade compared with diabetes support and education, but it did lead to re­ duced use of antidiabetes and cardiac medications, fewer hospitalizations, and lower cost, reported researchers at the 2013 American Diabetes Associa­ tion annual meeting. The study, called Look AHEAD,

Reduced Healthcare Utilization, Costs The rates of hospitalizations were Continued on page 15

Pooled Analysis Confirms CV Benefits of DPP-4 Inhibition By Mary Mosley Chicago, IL—Diabetes is known to confer approximately a 2-fold in­ creased risk for vascular disease, independent of other cardiovascular (CV) risk factors. The topic was dis­ cussed in a session at the 2013 Ameri­ can Diabetes Association (ADA) an­ nual meeting. The presence of diabetes is equivalent in risk to a history of

coronary heart disease. Key characteristics of the CV biopathology in patients with type 2 diabetes include: • Younger age • Asymptomatic disease or atypical symptoms • More advanced disease at the time of diagnosis

Continued on page 6

in th is is s u e

DIABETES MANAGEMENT. . . . . . . . 6 Adding linagliptin to basal insulin reduces hypoglycemia, improves A1c in older patients New predictors of outcomes in diabetes Lifestyle intervention beneficial in diabetes, but not for CV parameters

© 2013 Engage Healthcare Communications, LLC

was conducted at 16 centers in the United States. It enrolled 5145 over­ weight or obese patients with type 2 diabetes who were randomly assigned to intensive lifestyle intervention that was intended to promote weight loss or to diabetes support and education (see article, page 9).

EMERGING THERAPIES. . . . . . . 12 First SGLT-2 inhibitor approved by the FDA GLP-1 agonists may protect patients with diabetes from heart failure Albiglutide effective in various scenarios in type 2 diabetes

HEALTH ECONOMICS . . . . . . . . 15 Financial incentives can promote weight-loss maintenance Canagliflozin monotherapy can reduce costs of diabetes complications Comparing resource utilization and costs: saxagliptin versus sitagliptin Substantial costs for diabetes consumed by the diabetic foot and arthritis DRUG UPDATE . . . . . . . . . . . . . . 19 Nesina, Kazano, and Oseni: 3 alogliptinbased agents approved for treatment of patients with type 2 diabetes


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AHDB ADA 2013 Highlights by Dalia Buffery - Issuu