This chapter presents an analysis of sustainable development goals in the context of two mega-regional trade agreements: the Transatlantic Trade and Investment Partnership (TTIP) and the Trans-Pacific Partnership (TPP). These preferential trade agreements present a more efficient vehicle by which to promote sustainable development than the multilateral trading platform. The chapter discusses sustainable development and energy within the proposed TTIP. The TTIP aims to further economic growth, investment and trade between the United States and the European Union (EU), and could potentially have a very large impact as the U.S.–EU trade and investment flows are sizeable and a critical element in global commerce. The chapter argues that the TTIP has the potential to foster sustainable development, energy efficiency, and energy security.