2021 AANextra by American Academy of Neurology

AANextra AN OFFICIAL PUBLICATION OF THE AMERICAN ACADEMY OF NEUROLOGY

April 17–22, 2021

FAUCI, KOROSHETZ, OTHER TOP RESEARCHERS TO PRESENT LATEST ADVANCES AT PLENARY SESSIONS From the hottest and timeliest science around COVID-19 and other important clinical topics to controversial issues and a yearend review of top findings, this year’s plenary sessions will feature an impressive lineup of researchers showcasing their very latest breakthroughs in neuroscience. For more information, visit AAN.com/21AM.

For the first time, the 2021 Hot Topics Plenary Session will focus entirely on one important issue, the global COVID-19 pandemic. Join the keynote address with Walter J. Koroshetz, MD, FAAN, and Anthony S. Fauci, MD, who have been at the forefront of the public health crisis. Continued on page 8 u

Fauci

Koroshetz

Latest Innovations of Significance Highlighted in Emerging Science Abstracts

Experiential Learning Areas Offer Fun, Unconventional Learning Opportunities

If you’re looking for the most timely, significant, and innovative research in neurology then look no further than the 13 abstracts set to be showcased in this year's Emerging Science program. Eleven abstracts will be presented on Sunday, April 18, from 3:00 p.m. to 4:30 p.m. ET and two abstracts will be presented during the Clinical Trials Plenary Session on Tuesday, April 20, from 10:00 a.m. to 12:30 p.m. ET. Abstracts selected for Emerging Science presentations include key aspects of research conducted after the October 2020 abstract submission deadline and must be new and of sufficient scientific importance to warrant expedited presentation and publication.

Don’t miss the Experiential Learning Areas for short, engaging talks and presentations designed to help you advance intellectually, personally, and professionally. Explore six areas that will spark your imagination and help you learn in fresh ways. From conversation corners to talks with physicians and AAN staff, you'll find plenty of opportunities to engage with speakers. Learn more about each area and see complete talk lineups at AAN.com/ELA.

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Comedian Jim Gaffigan to Headline Live Saturday Evening Entertainment at Annual Meeting See page 21 u

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INSIDE

Bestselling Author, Adventurer Alison Levine to Give Live Inspirational Talk at Annual Meeting

Abound to Connect and Engage 19 Opportunities at Networking/Entertainment Hub Why the AAN Is Indispensable at the 22 Discover AAN Showcase

The Vision of the AAN is to be indispensable to our members.

Issue Highlights

The Mission of the AAN is to promote the highest quality patient-centered neurologic care and enhance member career satisfaction.

Vote on Board Nominees, Bylaws Change During April 17 Virtual Business Meeting

AAN members are urged to vote on the slate of nominees for AAN officer and director positions for the 2021–2023 term during the AAN’s virtual 2021 Business Meeting on Saturday, April 17, from 4:00 p.m. to 5:00 p.m. ET.

Participate in National Institutes of Health Day, Tuesday, April 20

Join NINDS Director Walter J. Koroshetz, MD, FAAN; Deputy Director Nina Schor, MD, PhD; and other members of the NINDS staff at 1:30 p.m. ET as they describe the present state of NINDS and NIH grants programs, strategic focus, funding priorities, and how you can participate as a researcher.

Engage with Industry, Discover Latest Products at the Virtual Exhibit Hall

Visit the engaging and dynamic virtual Exhibit Hall to explore the latest products available to help improve your service to patients.

Reminders Have You Seen the Leaderboard?

Take a Mini Escape with the Aquarium Cam!

Challenge your friends to see who has earned bragging rights for the day and a chance to win a daily prize. Earn points by attending events and visiting different areas of the virtual platform. Visit the Leaderboard to see who has the top scores.

For a quick change of pace, spend a few minutes watching divers feed the sharks at the Great Lakes Aquarium, exploring shipwrecks from around the world, marveling at the moon jellies and anemones in a tide pool, and more! Head to the Live Well Experiential Learning Area and click on the Aquarium Cam! 

Platform Tips Need help with the virtual platform? Use the chat icon on the lower righthand side of the screen to access tech support.

2021 Annual Meeting • AANextra

Contact Information: American Academy of Neurology 201 Chicago Avenue Minneapolis, MN 55415 USA Phone: (800) 879-1960 (Toll Free) or (612) 928-6100 (International) Fax: (612) 454-2744 Email: memberservices@aan.com Website: AAN.com AAN Chief Executive Officer: Mary E. Post, MBA, CAE Managing Editor: Angela Babb, MS, CAE, APR Editor: Tim Streeter Writers: Ryan Knoke, Sarah Parsons Designer: Andrew Imholte Email: aannews@aan.com AANextra is published by the American Academy of Neurology. The American Academy of Neurology’s registered trademarks and service marks are registered in the United States and various other countries around the world. “American Brain Foundation” is a registered service mark of the American Brain Foundation and is registered in the United States.

Bestselling Author, Adventurer Alison Levine to Give Live Inspirational Talk at Annual Meeting Alison Levine, the first American Women's Everest Expedition team captain, adjunct faculty member at the Thayer Leader Development Group at West Point, and New York Times bestselling author of On the Edge: Leadership Lessons from Everest and Other Extreme Environments will inspire Annual Meeting attendees between 1:00 p.m. and 2:00 p.m. ET on Tuesday, April 20, with her talk “On the Edge: The Art of High-impact Leadership.” No one understands the commitment and leadership necessary to achieve extreme results better than Levine. Despite having been born with a life-threatening condition requiring two cardiac surgeries and suffering from Raynaud’s disease, a condition that cuts the blood flow to her fingers and toes in cold temperatures leaving her at extreme risk for frostbite, she has overcome her challenges to become a history-making adventurer, completing the Adventure Grand Slam of climbing the Seven Summits—the highest peak on each continent—skiing to both the North and South Poles, and being honored as one of only a few presenters at the highly prestigious World Economic Forum in Davos alongside world leaders and top CEOs. “At a time when we are faced with incredible challenges that are beyond our control, we could all use some inspiration,” said Carlayne E. Jackson, MD, FAAN, chair of Meeting Management Committee. “Dealing with the COVID-19 pandemic can in many ways seem similar to Alison Levine's experience climbing Mount Everest and we can learn a lot about how to cope with adversity from the leadership principles she will share.” Levine’s live 45-minute inspirational talk will focus on the importance of teamwork, determination, tenacity, and the ability to adapt to changing environments as the critical keys to success in all facets of one’s life and career—from Wall Street to the mountain. She will draw on her experience as team captain to make a compelling case that the leadership principles that apply in the world of extreme adventure also apply to today’s rigorously competitive work environments. “Imagine yourself on the highest mountain in the world,” she explains in her best-selling book. “You have to deal with the physiological effects of extreme altitude—along with bonechilling temperatures, battering winds, and a climbing team that's counting on all of its members to make smart decisions. There's simply no room for poor judgment—one mistake or misstep can result in an ‘unrecoverable error.’ In any situation where lives on are the line or the stakes are exceptionally high—there’s no better training ground for leaders than settings where people are pushed beyond their perceived limits.”

Levine

Connect with Your Alumni Community at Virtual Reunions Looking to connect with alumni from your alma mater, along with current faculty, residents, and fellows? Check out the Networking/ Entertainment Hub of the virtual Annual Meeting platform or search the program for your university’s name to find all scheduled alumni reunions. Offered during the meeting, these events will provide a great opportunity to network and catch up with your former colleagues and peers.

Levine’s live talk will be followed by a 15-minute Q&A session. Visit AAN.com/21AM and add this to your calendar. Sponsored by AAN Family of Publications, Neurology ® , Neurology ® Clinical Practice, Neurology ® Neuroimmunology & Neuroinflammation, Neurology ® Genetics, Continuum®, Neurology Today ® , and Brain & Life® with Wolters Kluwer Health, AAN Publishing Partner.

2021 Annual Meeting • AANextra

New Honorary Members Saluted During Presidential Plenary Session Two past editors-in-chief of the AAN’s flagship journal Neurology ® and the chief executive officer who led the Academy’s growth for 21 years will be recognized by AAN President James C. Stevens, MD, FAAN, at the Presidential Plenary which will be held virtually on Sunday, April 18, from 10:00 a.m.–1:00 p.m. ET. As Stevens noted in his letters below to each of the honorees, “You are joining the exclusive membership of a select 41 current members, including AAN Past Presidents, international giants such as a Nobel Prize winner, and elite Fellows of the AAN.”

Robert A. Gross, MD, PhD, FAAN

John H. Noseworthy, MD, FAAN

“In addition to your significant achievements in your time at the University of Rochester, you have made a significant impact to the AAN and the field of neurology since you became a member in good standing in 1984. You have attended 20 AAN Annual Meetings, served on the AAN Board of Directors, and participated in more than five AAN committees and several task forces and leadership activities. Most notable are your contributions to the Neurology ® journal as editor-in-chief. These accomplishments include:

“In addition to your significant achievements in your time as CEO of the Mayo Clinic, you have made a significant impact to the AAN and the field of neurology. You have been a member in good standing with the AAN since 1979. You have attended more than 20 AAN Annual Meetings, served on more than 10 AAN committees, and participated in several task forces and leadership activities. Most notable are your contributions to the Neurology ® journal.

Publication of short, easily digestible articles in print,

allowing for longer, more data-filled articles online—for all research articles Launch of three new subspecialty journals (Neurology ®

Clinical Practice, Neurology ® Neuroimmunology & Neuroinflammation, and Neurology ® Genetics)

A flourishing Resident & Fellow Section, with its trainee team

publishing a weekly journal section online Launch of three subspecialty websites (Without Borders;

Innovations in Care Delivery; Equity, Diversity, & Inclusion) Infographics with each weekly online issue presenting an

overview of an article Disputes & Debates online correspondence section Publication of open access articles New authorship and open data policies, creating greater

transparency Reporting of reviewers’ names to Publons for credit in

academic circles Weekly podcasts with interviews of article authors—with

CME credit available Formation of EDI teams to ensure that our processes have

adequate rigor and responsibility during peer review Redesigned website and print journal, enabling easier

reading and greater discoverability

2021 Annual Meeting • AANextra

“You served 2.5 years (2007–2009) as editor-in-chief of Neurology, at a time when the publishing industry faced the uncertainty of transition from print to electronic media and when the large number of articles in the journal made it difficult to read. New subspecialty journals had proliferated and threatened to erode the number and quality of submitted manuscripts. Editors edited paper manuscripts and requested reviewers from memory, with staff faxing manuscripts to all parts of the globe for review. “You adopted the vision of Neurology being the peer reviewed journal for clinical neurologists. Under your leadership, Neurology added a larger team of expert editors with clearly defined responsibilities and workflows, resulting in a group of committed associate editors and specialized editorial staff to streamline editing and peer review; designed a new shorter format for the journal; transitioned to weekly publication; and focused on performance metrics for rapid review and decision-making. New products included the Clinical Pathologic Conferences, NeuroImages, Clinical Implications of Neuroscience Research, enhanced electronic offerings by and for residents and fellows, the successful weekly Neurology podcasts, and criteria for level of evidence. The journal adopted new policies to avoid ghost writing and duplicate submissions and mandated that all authors declare all sources of possible bias.”

Catherine M. Rydell, CAE “With your efforts, the board’s high expectations and commitment to drive the AAN forward have moved us from a solid organization in 1999 when you began your role as CEO of the American Academy of Neurology to the exceptional organization of today. As programs and services for members grew, you expanded staff with the help of a competent and innovative executive staff team. In recent years under your leadership, continual strategic planning has become the norm, backed by data, member input, and environmental scans. This has enabled the AAN to be more proactive, rather than reactive, which is critical in this rapidly shifting health care environment. These are but a few of the AAN’s accomplishments during your tenure as CEO: Membership has grown from 14,000 in 1999 to 36,000 today New, permanent headquarters in downtown Minneapolis Annual Meeting attendance has grown to upwards of

15,000 attendees Operating budget has increased from $11M in 1999 to $64.7M

in 2020 and long-term reserves have grown from $7M to $78.7M Launched several spoke journals from our flagship scientific

journal Neurology ® and launched Neurology Today ®

Created the Axon Registry ®, vitally important to analyzing

Established a permanent office in Washington, DC, in 2005,

and BrainPAC in 2007 Strengthened advocacy with Neurology on the Hill and

scored significant victories on Capitol Hill and with CMS for neurology Supported successful Palatucci Advocacy Leadership Forum,

with 500+ graduates, led to creation of nine other AAN Leadership Programs Reaffirmed AAN’s commitment to equality, diversity,

and inclusion Launched Regional Conferences with the Fall Conference

in 2002 Launched first annual Sport Concussion Conference in 2015 International membership now includes 141 countries;

strengthened our relationships with such global bodies as World Federation of Neurology and the European Academy of Neurology Spun off the AAN Foundation as the independent American

Brain Foundation in 2012 Supported the creation of free Brain Health Fairs in

conjunction with the Annual Meeting Launched public-facing magazine Neurology Now ®, which

has evolved into Brain & Life® and the BrainandLife.org website and patient book series

Supported AAN’s early entry into social media with now

nearly 400,000 member and public followers on our numerous social media channels Championed personalized member experiences on AAN.

com and expansion of online education

patient care data

2021 Annual Meeting • AANextra

Experience the Annual Meeting Your Way with Curated Interest-based Program Tracks Don’t miss these specially curated course lineups, designed to help you experience the meeting your way and maximize your time with consecutive programming intended to meet your individual career stage, path, and needs. Plan your experience by filtering by program tracks at AAN.com/2021Program and then add specific programs to your calendar.

Academic Medicine Track

Additional Tracks

Designed to help academic neurologists in early career and development or looking to launch into private practice or academics.

In addition to formal tracks, we also have also curated lists of suggested programs to attend for the following groups based on the unique needs of each group.

Advanced Practice Provider Track Created for cutting-edge advanced practice providers who are new to neurology.

Business of Neurology Track Perfect for private practitioners and business administrators interested in starting a new practice or learning the fundamentals of neurology business.

Career Essentials Track Offering medical students and residents help with early career and development and/or help launching into private practice or academics.

COVID-19 Track This track has been curated to highlight courses that will discuss implications in neurologic care for past or current patients that have been diagnosed with COVID-19.

Futures in Neurological Research Track This track offers both formal coursework and learning sessions to round out research-interested trainees’ Annual Meeting experience.

Neurohospitalist Track Created specifically for neurohospitalists whose primary focus is inpatient care.

Spanish-language Track Look for education courses, scientific updates, and networking sessions, all delivered in Spanish.

2021 Annual Meeting • AANextra

Academic Business Administrators April 18 Designed to help business administrators take their departments to the next level and get ready to face unique challenges and opportunities. This day-long set of programs will cover a variety of topics including service lines, faculty compensation plans, and more. Graduate Medical Education Showcases events, programs, and sessions best suited for residents, fellows, directors, and coordinators. Undergraduate Medical Education Student Programs Curated events, programs, and sessions best suited for medical students. Highlights include the Medical Student Symposium, SIGN Meeting, and Futures in Neurological Research Boot Camp. For more information, visit AAN.com/21AM.

C R E AT I N G H O P E T H R O U G H I N N O VAT I O N At E i s a i , eve r y t h i n g w e d o i s g u i d e d by a s i m p l e principle: patients and their families come first. We s p e n d t i m e w i t h t h e m . We l i s t e n a n d w e l e a r n a b o u t t h e i r l i ve s , t h e i r d e s i re s a n d t h e i r g re a t e s t n e e d s . We c a l l t h i s h u m a n h e a l t h c a re o r h h c , g i v i n g first thoughts to patients and their families and h e l p i n g i n c re a s e t h e b e n e f i t s h e a l t h c a re p rov i d e s . O u r h h c m i s s i o n i s w h a t d r i ve s u s t o d i s c ove r i n n ova t i ve s o l u t i o n s a n d t h e r a p i e s t h a t h e l p a d d re s s u n m e t n e e d s w i t h i n t h e c o m m u n i t i e s t h a t w e s e e k t o s e r ve .

Eisai is a proud supporter of the AAN Annual Meeting.

T O L E A R N M O R E , P L E A S E V I S I T W W W. E I S A I . C O M / U S CORP-US2790

March 2021

Fauci, Koroshetz, Other Top Researchers to Present Latest Advances at Plenary Sessions continued from the cover Presidential Plenary Session

Hot Topics: Neuro-COVID Plenary Session

This session features the AAN’s premier lecture awards for clinically relevant research and a presentation by a leading lecturer. Top researchers speak on some of the most significant findings in neurology in 2021. AAN President James C. Stevens, MD, FAAN, will kick off the session with a presentation of the President’s Award and Presidential Lecture. After that, tune in for a live address from AAN Chief Executive Officer Mary E. Post, MBA, CAE, followed by a few words from AAN President Elect Orly Avitzur, MD, MBA, FAAN. The session moderator will then introduce this year's list of superb lecturers.

Sunday, April 18 at 10:00 a.m. ET

Moderator: Natalia S. Rost, MD, MPH, FAAN, FAHA, Boston, MA

residential Lecture: Disruption: How to Pivot P from Uncertainty to Success—The AAN Story James C. Stevens, MD, FAAN, Fort Wayne, IN President, American Academy of Neurology . Houston Merritt Lecture: Where’s the Vision? H The Importance of Visual Outcomes in Neurological Disease Steven Galetta, MD, FAAN, New York, NY idney Carter Award in Child Neurology: Gene S Therapy Fulfills the Promise for Kids with Neuromuscular Disease Jerry R. Mendell, MD, FAAN, Columbus, OH obert Wartenberg Lecture: Prevention and R Parkinson’s Disease—The Road Forward Caroline Tanner, MD, PhD, FAAN, San Francisco, CA

Saturday, April 17 at 5:00 p.m. ET

Moderators: Natalia S. Rost, MD, MPH, FAAN, FAHA, Boston, MA

Paul M. George, MD, PhD, MSE, Stanford, CA

Keynote Address: Anthony S. Fauci, MD Director of the National Institute of Allergy and Infectious Diseases and Chief Medical Advisor to President Joe Biden Walter J. Koroshetz, MD, FAAN Director of National Institute of Neurological Disorders and Stroke (NINDS)

Biology/Acute Illness of COVID-19 Sherry Chou, MD, MMSc, FNCS, Pittsburgh, PA

COVID-19 Disparities: An Urgent Call to Dismantle Structural Racism and Prioritize Justice Nicte I. Mejia, MD, MPH, FAAN, Boston, MA

omorrow, and Tomorrow, and Tomorrow: T Understanding Neurologic Syndromes Post-acute COVID-19 Serena Spudich, MD, MA, New Haven, CT Vaccine and Immunological Response Igor Koralnik, MD, FAAN, Chicago, IL

2021 Annual Meeting • AANextra

Contemporary Clinical Issues Plenary Session Monday, April 19 at 10:00 a.m. ET

Join for Fireside Chats After Plenary Sessions. Participate in live, moderated fireside chats with speakers immediately following the Frontiers in Neuroscience, Presidential, Contemporary Clinical Issues, Clinical Trials, and Controversies in Neurology Plenary Sessions. You are encouraged to submit your questions during the fireside chats for the opportunity to have speakers respond live.

Frontiers in Neuroscience

Saturday, April 17 at 10:00 a.m. ET This plenary session features basic and translational research related to clinical issues of importance. Hear from five outstanding speakers as they summarize their recent research finding and dive into the clinical implications of the results. Moderator:

Highlights issues most critical to practicing neurologists, including abstracts related to new therapeutic developments, clinical applications of basic and translational research, and innovative technical developments. The first three topics will be introduced by presenters followed by a commentary from the discussant. The second half of the session will feature standalone talks on various topics. Moderator: Peter Goadsby, MD, PhD, Los Angeles, CA

Abstracts: Long-term Survival of Participants in the CENTAUR Trials of AMX0035 for ALS Presenter: Discussant: Sabrina Paganoni, Timothy M. Miller, MD, PhD, Boston, MD, PhD, St. Louis, MA MO

Paul M. George, MD, PhD, MSE, Stanford, CA

Organization and Control of Hippocampal Circuits Ivan Soltesz, PhD, Stanford, CA

Decoding Speech Cortex Edward Chang, MD, San Francisco, CA

icrotubules in Health and Disease M Antonina Roll-Mecak, PhD, Bethesda, MD

Stem Cell Therapy for Spinal Cord Injury: Transition to the Clinic Mark H. Tuszynski, MD, PhD, FAAN, La Jolla, CA

Dissecting the Control of Blood Flow Through Brain Capillaries Andy Shih, PhD, Seattle, WA

Neuroimmunology Adverse Events Associated with Immune Checkpoint Inhibitor: A Retrospective, Pharmacovigilance Study Using FAERS Database Presenter: Discussant: Takahisa Mikami, Karin Woodman, MD, New York, NY MD, Houston, TX

Prevalence of White Matter Hyperintensities in a Population aged ≤50 both With and Without Mild Traumatic Brain Injury Presenter: Discussant: Teena Shetty, MD, Jack Tsao, MD, New York, NY DPhil, FAAN, Bethesda, MD Stem Cell Tourism/Regenerative Medicine Sean I. Savitz, MD, Houston, TX

Gene Therapy for Childhood Neuromuscular Syndromes Perry Shieh, MD, PhD, FAAN, Los Angeles, CA

Daylight Savings Time: Is There a Controversy? Phyllis Zee, MD, PhD, Chicago, IL

Continued on page 10 u

2021 Annual Meeting • AANextra

Fauci, Koroshetz, Other Top Researchers to Present Latest Advances at Plenary Sessions continued from page 9 Clinical Trials Plenary Session

Leriglitazone Improved Progression of Myelopathy-related Symptoms, and Reduced Cerebral Lesions in Patients with Adrenomyeloneuropathy in a Phase 2/3 Clinical Study Reza Seyedsadjadi, MD, Boston, MA

Tuesday, April 20 at 10:00 a.m. ET

Covers important clinical topics identified from other society meetings that affect patient care. The latest updates within several clinical trials conducted over the course of the last year will be presented.

FINTEPLA (Fenfluramine) Treatment Improves Everyday Executive Functioning in Patients with Lennox-Gastaut Syndrome: Analysis from a Phase 3 Clinical Trial Kim I. Bishop, PhD, Muncy, PA

Moderators: Deborah Hall, MD, PhD, FAAN, Chicago, IL

Holly E. Hinson, MD, MCR, FAAN, Portland, OR

ESCAPE-NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischemic Stroke) Michael Tymianski, MD, PhD, FRCSC, Toronto, ON, Canada Atogepant Significantly Reduces Mean Monthly Migraine Days in the Phase 3 Trial (ADVANCE) for the Preventive Treatment of Migraine Jessica Ailani, MD, FAAN, McLean, VA Efficacy and Safety of Lower-sodium Oxybate in a Phase 3, Placebo-controlled, Double-blind, Randomized Withdrawal Study in Adult Participants with Idiopathic Hypersomnia Yves Dauvilliers, MD, PhD, Montpellier, France Efficacy, Safety, and Tolerability of Efgartigimod in Patients with Generalized Myasthenia Gravis: Analysis of the Phase 3 ADAPT Study James F. Howard, Jr., MD, FAAN, Chapel Hill, NC Sustained Benefits for 10 kHz Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy—Six Month Results from a Multicenter Randomized Controlled Trial Erika A. Petersen, MD, FAANS, FACS, Little Rock, AR Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease Raúl Martínez-Fernández, MD, PhD, Madrid, Spain

Efficacy and Safety Results of the Avalglucosidase Alfa Phase 3 COMET Trial in Late-onset Pompe Disease Patients Hani Kushlaf, MD, FAAN, Cincinnati, OH

2021 Annual Meeting • AANextra

Controversies in Neurology Plenary Session Wednesday, April 21 at 10:00 a.m. ET

This session features experts discussing the most current and controversial issues in neuroscience. Tune in for a scholarly debate between two expert speakers, each advocating for one side of a single topic followed by a rebuttal. Moderators: Martinson K. Arnan, MD, Kalamazoo, MI

Amy R. BrooksKayal, MD, FAAN, Sacramento, CA

Teleneurology: Can It Replace In-person Visits? Yes: No: Tamika M. Burrus, Amy Guzik, MD, MD, FAAN, Santa Winston-Salem, Monica, CA NC Shattering the Clock: Should There Be a Time Window for Acute Stroke Intervention? Yes: No: Maarten G. Jeffrey L. Saver, Lansberg, MD, MD, FAAN, Los Stanford, CA Angeles, CA Should Amyloid Continue to Be Targeted in Alzheimer’s? Yes: No: Jeffrey Cummings, Mary Sano, PhD, MD, FAAN, Las New York, NY Vegas, NV

Neurology Year in Review Plenary Session Thursday, April 22 at 10:00 a.m. ET

This session looks back at the past year of research, highlighting some of the most relevant strides made in neurology subspecialties, including movement disorders, stroke, and headache. One speaker will examine a topic of particular interest that will examine how we diversify the neurology workforce. Moderator: Fernando Testai, MD, PhD, Chicago, IL

Emerging Therapies for Pediatric Metabolic Disorders Marc C. Patterson, MD, FAAN, FRACP, Rochester, MN

Epilepsy Seizure Detection and Device Intervention Kathryn A. Davis, MD, Philadelphia, PA

Stroke Recovery Heidi M. Schambra, MD, New York, NY

Diversification of the Neurology Workforce Bruce Ovbiagele, MD, MSc, FAAN, San Francisco, CA

Headache Rashmi Halker-Singh, MD, FAAN, Scottsdale, AZ

Therapeutics in Movement Disorders Irene Malaty, MD, FAAN, Gainesville, FL

MEM: 20 FAAN Recruitment Ad—Half Page Horizontal> AN Placed in AANnews 8.25 x 5.25 +0.125 bleed, 4C

SHINE A LIGHT ON YOUR ACHIEVEMENTS Apply for a prestigious Fellow of the American Academy of Neurology (FAAN) designation.

AAN.com/FAAN

Vote on Board Nominees, Bylaws Change During April 17 Virtual Business Meeting AAN members are urged to vote on the slate of nominees for AAN officer and director positions for the 2021–2023 term during the AAN’s 2021 Business Meeting to be held virtually on Saturday, April 17, from 4:00 p.m. to 5:00 p.m. ET during the Annual Meeting. The meeting will include reports from officers on the accomplishments of the AAN during 2020 and a review of the organizations’ fiscal health. The classes of membership entitled to vote on any matter during any business meeting of the Academy are Fellow and Neurologist members, and Honorary and Senior members who had voting privileges in their most recent previous category of membership.

Officers

Stevens

Avitzur

The current President Elect, Orly Avitzur, MD, MBA, FAAN, will begin her term as President on April 23, 2021. The current President, James C. Stevens, MD, FAAN, will then serve on the Board of Directors as Immediate Past President. The following additional directors will serve as ex officio directors beginning on April 23: Bruce H. Cohen, MD, FAAN, Chair, Advocacy Committee

President Elect – Carlayne E. Jackson, MD, FAAN

(ex officio)

Vice President – Janis M. Miyasaki, MD, MEd, FRCPC, FAAN

Brad C. Klein, MD, MBA, FAAN, Chair, Medical Economics

and Practice Committee (ex officio)

Secretary – Sarah M. Benish, MD, FAAN

José G. Merino, MD, MPhil, FAHA, FAAN, Editor-in-Chief of

Treasurer – Charles C. Flippen II, MD, FAAN

Neurology ® (ex officio)

Maisha T. Robinson, MD, MSHPM, FAAN, Chair, Member

Engagement Committee (ex officio) Mary E. Post, MBA, CAE, Chief Executive Officer (ex officio,

non-voting) Jackson

Miyasaki

Flippen

Benish

Directors Wayne E. Anderson, DO, FAHS, FAAN Brenda Banwell, MD, FAAN

Cohen

Charlene Gamaldo, MD, FAAN, FAASM

Klein

Robinson

Merino

Post

The Academy is comprised of two legal entities, the AAN and the AAN Institute. Most of the elected members of the AAN Board of Directors also serve ex officio on the Board of Directors of the AAN Institute, which includes an independent secretary-treasurer and additional members who serve in ex officio capacities. The AAN Institute Board of Directors will include the following additional members:

James N. Goldenberg, MD, CPI, FAPCR, FAAN Larry B. Goldstein, MD, FAHA, FAAN Lily Jung Henson, MD, MMM, FAAN Shannon M. Kilgore, MD, FAAN Brett M. Kissela, MD, MS, FAHA, FAAN Bruce Ovbiagele, MD, MSc, MAS, MBA, FAAN

Jonathan P. Hosey, MD, FAAN, AAN Institute

Secretary-Treasurer Lyell K. Jones, Jr., MD, FAAN, Chair, Quality Committee

(ex officio) Natalia S. Rost, MD, MPH, FAHA, FAAN, Chair, Science

Committee (ex officio) Anderson

Banwell

Gamaldo

Goldenberg

Goldstein

Joseph I. Sirven, MD, FAAN, Chair, Education Committee

(ex officio)

Henson

Kilgore

2021 Annual Meeting • AANextra

Kissela

Ovbiagele

Hosey

Jones

Rost

Sirven

There also will be consideration of amendments to Article VI, Section 2B of the AAN Bylaws relating to the term for the Editor-inChief of Neurology ® as follows: B. The Board of Directors shall appoint the Editor-in-Chief, who shall have responsibility for all the contents of the journal NEUROLOGY and oversee the activities of the Editorial Board. The Editor-in-Chief will serve one five- six-year term, which is renewable for another five- four-year term, unless otherwise approved by the Board of Directors.

The proposed amendment would follow the industry standard for academic medical journals, which is a term increment of five years, renewable for another five years. The proposed amendment would also allow the Board of Directors to make an exception to the term length and increments, if necessary, in order to align the end of the term with the academic year. The AAN Bylaws may be amended at the Business Meeting by the vote of at least two-thirds of the voting members present and voting. For more information, contact Karen Kasmirski at kkasmirski@aan.com.

Participate in National Institutes of Health Day, Tuesday, April 20 Launched in 1950 after vigorous lobbying by AAN founder A.B. Baker and second AAN President Pierce Bailey as an institute within the National Institutes of Health (NIH), the National Institute of Neurological Disorders and Stroke (NINDS) researches the brain and nervous system and uses that knowledge to reduce the burden of neurologic disease. Join NINDS Director Walter J. Koroshetz, MD, FAAN; Deputy Director Nina Schor, MD, PhD; and other members of the NINDS staff on Tuesday, April 20 at 1:30 p.m. ET, as they describe the present state of NINDS and NIH grants programs, strategic focus, funding priorities, and how you can participate as a researcher. There will be several talks with opportunities for live Q&A.

Koroshetz

Schor

All Eastern Time

Topic

Presenter

1:30 p.m.–2:00 p.m.

Welcome to NIH Day/Updates on Post-Acute Sequelae of SARS-CoV-2 infection (PASC)

Walter J. Koroshetz, MD, FAAN, NINDS

2:05 p.m.–2:35 p.m. NINDS Strategic Plan

Nina Schor, MD, PhD, NINDS

2:40 p.m.–3:10 p.m.

Learn About Opportunities to Work with the NIH Intramural Program

Avi Nath, MD, NINDS

3:15 p.m.–3:45 p.m.

NIH Grant Review Process and Common Pitfalls in Review

Shanta Rajaram, PhD, NINDS

3:50 p.m.–4:20 p.m. K Awards and Training Programs—Planning for a Career as an NIH Investigator

Adam Hartman, MD

4:25 p.m.–4:55 p.m. NIH Funding and Professional Development Opportunities for Diverse Researchers

Richard Benson, MD, PhD, NINDS

5:00 p.m.–5:30 p.m. Clinical Trials and Networks—NeuroNEXT, StrokeNET, SIREN; Alzheimer’s Clinical Trials Consortium; ADRD Opportunities

Clinton Wright, MD, NINDS

5:35 p.m.–6:05 p.m. Translational Research, NINDS Programs and Resources to Advance Therapies from Bench to Bedside

Amir Tamiz, PhD, NINDS

2021 Annual Meeting • AANextra

Experiential Learning Areas Offer Fun, Unconventional Learning Opportunities continued from the cover HeadTalks

Careers in Neurology This popular ELA is back! Look for presentations designed to engage audiences through unconventional platforms that offer a truly transformational exploration of non-traditional neurology topics.

Highlights include: Beyond the White Coat: Who We Are, Where We Live,

What We Love Saturday, April 17, 3:00 p.m.–3:35 p.m. ET Ann H. Tilton, MD, FAAN; Ralph L. Sacco, MD, MS, FAHA, FAAN; Cynthia L. Comella, MD, FAAN; Nina F. Schor, MD, PhD, FAAN; and Joseph F. Drazkowski, MD, FAAN

Have you ever wanted to learn more about what your neurology colleagues do in their free time? This session will feature homes, hobbies, and unique talents of a variety of neurologists. Neuro-oncology Around the World—Global

Perspective on Brain Cancer Patient Care Monday, April 19, 3:00 p.m.–3:35 p.m. ET Maciej M. Mrugala, MD, PhD, MPH, FAAN; Agnieszka Slowik, MD, FAAN; Hui K. Gan; Alejandro Zavala Reina; and Kathy Oliver

Faculty will share how the specialty of neuro-oncology is practiced in their countries, what the training is like, and what patients face after the diagnosis. They will also discuss what support systems are available, what main barriers and difficulties are, what the insurance reimbursement is, and how neuro-oncologists are trained. The Neurology of Wine Tasting

Tuesday, April 20, 5:00 p.m.–5:35 p.m. ET Jaime R. Lopez, MD

Why does wine in certain situations cause strong emotional responses, even before it is tasted? We will also explore the idea of wine in COVID testing and describe how wine is “tasted.” Finally, we encourage you to grab a glass—or two— of wine; if two, then we recommend two different wines for interactive wine tasting.

2021 Annual Meeting • AANextra

Take part in various talks and networking sessions to help you explore, navigate, and advance your career—no matter what stage you’re in.

Highlights include: What Should Applicants Look for in a Program?

Saturday, April 17, from 1:00 p.m.–1:30 p.m. ET Peter Hannon, MD, and Adam De Havenon, MD

This presentation is for medical students and residents to better understand what they should be considering when applying for residency and fellowship. Drawing on years of program director experience in neurology residency and fellowship, the presenters' focus will be on what makes a training program the right fit for an applicant, and not the other way around. K Is for Career Development

Tuesday, April 20, from 9:00 a.m.–9:30 a.m. ET Holly E. Hinson, MD, MCR, FAAN

Interested in applying for a K but don't know where to start? This session will cover the different types of Ks, how a K differs from other Career Development Awards, the sections of the application, and hints to get started. Attendees will also learn what happens once the application is submitted and the basics of study section, as well as a typical timetable for review. Finding and maximizing appropriate mentorship will be stressed, along with tips and tricks to navigate this key area. The session will end with time for attendee questions. How the Neuroscience of Bias Changed My Career

Thursday, April 22, from 9:00 a.m.–9:30 a.m. ET Jose H. Posas, MD, FAAN

In this talk, faculty will delve into how they were able to channel anger and outrage at health care disparities they were seeing around them into actionable items on a rising agenda that has helped them help their patients, their community, and their future colleagues. Faculty will discuss some of the things they don't teach in medical school that have a tremendous impact on shaping how a neurologist can shape their career. Faculty will advise budding neurologists and share wisdom from stumbles in their own career path.

New! Academic Neurology Engage in a variety of presentations and conversations and access AAN programs and resources designed for those at every level of academia. Celebrate the AAN academic award recipients including the A.B. Baker Award for Lifetime Achievement in Neurologic Education and awards and scholarships for program directors, clerkship directors, consortia, residents, and medical students. Highlights include: Different Pathways to Becoming a Chair

Saturday, April 17, from 4:00 p.m.–4:30 p.m. ET Frances E. Jensen, MD, FAAN; Cathy A. Sila, MD, FAAN; and Robin Brey, MD, FAAN

This panel will discuss essential responsibilities and traits individuals need to address while considering a future as a chair. Topics will include the timing of taking such a leadership position in one's career, advantages of prior leadership roles, and the effect of the position on other individual pursuits such as research or education. Turning “Diversity Tax” into Currency in Neurology

Sunday, April 18, from 9:00 a.m.–9:30 a.m. ET Roy H. Hamilton, MD, MS, FAAN

Medical trainees and faculty who are persons of color, women, LGBTQI, or hail from other groups that are underrepresented in medicine are often called upon disproportionately to help advance the diversity mission of their academic institutions. This additional obligation, sometimes referred to as the “diversity tax,” can take time away from other activities that are considered important for meeting traditional career benchmarks, can have an unintended negative impact on professional development, and can contribute to career dissatisfaction and burnout. The objectives of this talk are to recognize the burden that diversity tax places on certain populations of practicing neurologists and trainees; discuss strategies for finding the right balance between promoting diversity-related activities and dedicating oneself to traditional career goals; and present practical strategies for translating diversity-related efforts into activities that are considered meritorious for career development in neurology.

New! Advancing Leadership in Neurology Look for unique opportunities to learn about core leadership competencies, including how to lead in the virtual world, and topics around equity, diversity, and inclusion. The area is designed to enhance attendees’ leadership potential and help train, support, and prepare them for desired leadership roles. Highlights include: Blind Spots: The Impact of Conscious and

Unconscious Biases Sunday, April 18, 4:00 p.m.–5:30 p.m. ET Charles C. Flippen, II, MD, FAAN; Jeffrey C. McClean, II, MD, FAAN; Laraine Kaminsky; and Janis Miyasaki, MD, FAAN

In a neurologic exam, you don't expect your patient to find their own blind spot, so why do we assume we can diagnosis our own? Following a live panel discussion, join us for interactive breakout sessions and an open panel discussion with AAN leaders. Health Care Disparities in Populations

Tuesday, April 20, 6:00 p.m.–6:30 p.m. ET Alejandro Vargas, MD, and Sharon Lewis, MD

This talk will highlight issues concerning health care disparities related to neurology. Come participate in an open forum for discussion on tackling this obstacle and constructive ways to promote awareness. Navigating Conflict in a Virtual World

Thursday, April 22, 4:00 p.m.–4:30 p.m. ET Barbara L. Hoese, Pentecore Coaching, LLC

Navigating conflict is a natural part of work and life today. Whether it’s in your institution or practice, conflict occurs because of differences in personalities, goals or, simply put, an unvoiced or unmet need. The key to navigating conflict is to accept that it occurs, not shy away from it, and turn it into productive conversations. This session will focus on types of conflict that occur and share five approaches to dealing with conflict that are productive and healthy.

Academic Neurology: What Is the AAN Doing to Help

Academic Neurology Saturday, April 17, from 9:00 a.m.–9:30 a.m. ET Ralph L. Sacco, MD, MS, FAHA, FAAN

The AAN has launched an academic initiative to help bring together many of the resources, products, and programs that help support academic neurologists across their lifespan, as well as build new ones to meet your needs. Building on our strong foundation of supportive programs for medical students, neurology clerkship directors, residents, residency program directors, fellows, and fellowship directors, we are expanding our reach to new programs for department chairs, division directors, academic clinicians and researchers, APPs, and other members of departments of neurology. Come hear what the AAN is doing for academic neurology and let us know what else we can do to help you.

Continued on page 16 u

2021 Annual Meeting • AANextra

Experiential Learning Areas Offer Fun, Unconventional Learning Opportunities continued from page 15 Live Well Learn about self-improvement and resiliency, work-life balance and satisfaction, and how to enhance both personal and professional well-being. Highlights include: Family Caring and Parenting

Sunday, April 18, 9:00 a.m.–9:30 a.m. ET Amtul Farheen, MD, FAAN; Nancy Hammond, MD; Paul G. Mathew, MD, FAAN

This panel discussion will address unique challenges neurologists face while being both doctors and caring for children, parents, or family members. This talk will be an open discussion about healthy personal relationships and parent wellness. What About Wellness for Residents and Fellows?

Tuesday, April 20, 3:00 p.m.–3:30 p.m. ET Aimee Aoi Sato, MD

Why is it so hard to feel well during residency and fellowship? Addressing organizational, systemic, and cultural factors of wellness are crucial, but take time and are unfortunately often not in the control of residents. We will focus on concrete things that you, as the resident or fellow, can do to increase your well-being. Exercise and Physical Activity in the Time of COVID-19

Tuesday, April 20, 5:00 p.m.–5:30 p.m. ET Ann Marie Collier, MD

This talk will address the impact of isolation during the current COVID-19 pandemic on our health and discuss ways to incorporate healthy habits of moving and exercising to boost one's sense of wellness and overall health.

New! Pioneering Policy, Practice, and Performance: Staying Ahead of Change Look for an exciting variety of talks designed to empower attendees to improve their practice and increase revenue through innovation and advocacy.

Highlights include: Meet Your Practice Support Network: Ask Us Anything

About Managing Your Practice Sunday, April 18, 6:00 p.m.–7:00 p.m. ET Michael E. Markowski, DO, FAAN; Gurdesh Bedi, MD, FAAN; and Marcia Dover, MD

Learn about the AAN’s resources for solo and small practitioners and be sure to bring questions for the panel. Neurology Networking & Advocacy Through

Social Media Monday, April 19, 2:00 p.m.–3:00 p.m. ET Kara Stavros, MD; Ima M. Ebong, MD; Justine Ker; Jeff Kraakevik, MD; Kathrin LaFaver, MD, FAAN; and Aarti Sarwal, MD, FAAN

Social media utilization for networking, advocacy, and education in neurology has increased over the years. This will be a panelist-based discussion and Q&A on how social media can be used to foster community and increase visibility for neurology-centered topics, as well as motivate current and inspire future neurologists. This talk is also live and interactive – learn how to advocate for patients and neurology and enhance your social media presence, in real time! 2021 Coding Odyssey

Tuesday, April 20, 2:00 p.m.–3:00 p.m. ET Brian T. Cabaniss, MD, and Meghan Ashley Ward, MD

The outpatient E/M coding changes which went into effect at the start of 2021 have resulted in new challenges for our members. Through interactive case examples, faculty will guide the audience through the nuances of billing based on time and medical decision making with this new code set. Each case will be followed by an open discussion period to address questions.

2021 Annual Meeting • AANextra

Heat shock proteins have the potential to change the landscape of proteinmisfolding diseases Heat shock proteins (HSPs) are the body’s natural response to protect cells, triggered when a cell is under stress1-3 Cellular stress caused by protein misfolding and aggregation can be an underlying factor in many neuromuscular diseases.

HSP70 could be the foundation for addressing protein-misfolding diseases2,4,5 By focusing on heat shock proteins, speciﬁcally HSP70, a number of conditions may be addressed.

To learn more about HSP70 and its role in correcting protein misfolding, visit

DiscoverHSP.com

References: 1. Lindquist S. The heat-shock response. Annu Rev Biochem. 1986;55:1151-1191. doi:10.1146/annurev.bi.55.070186.005443 2. Kirkegaard T, Roth AG, Petersen NH, et al. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature. 2010;463(7280):549-553. doi:10.1038/nature08710 3. Kalmar B, Greensmith L. Cellular chaperones as therapeutic targets in ALS to restore protein homeostasis and improve cellular function. Front Mol Neurosci. 2017;10:251. doi:10.3389/ fnmol.2017.00251 4. Sarkar S, Roy S. A mini review on heat shock proteins (HSPs): special emphasis on heat shock protein70 (HSP70). BN Seal J Sci. 2017;9(1):129-138. 5. Kakkar V, Meister-Broekema M, Minoia M, Carra S, Kampinga HH. Barcoding heat shock proteins to human diseases: looking beyond the heat shock response. Dis Model Mech. 2014;7(4):421-434. doi:10.1242/dmm.014563

AAN Industry Roundtable Celebrates Record 45 Partners The AAN has long recognized the value of partnering with industry on projects of common interest. Since its founding in 1994, the Industry Roundtable (IRT) has partnered with the AAN to share vision, intellect, and financial resources with the focus on improving the quality of patient care. The IRT provides a unique forum for the AAN and industry representatives to stay connected and share ideas and resources with the neurology community to foster positive engagement, ensure effective communication, and share opportunities to support the field of neurology and patients with neurologic disease. “This journey has taken us to new levels of transparency and cooperation to benefit our members and the patients that they serve,” said Jonathan P. Hosey, MD, FAAN, the AAN’s physician liaison to industry. “When we focus on providing the best neurologic care to patients, we all find success.” Thirteen new companies joined the IRT in 2021, marking a record 45 IRT partners. Thank you to the following: $50K Companies

Genentech, a member of

the Roche group

AbbVie, Inc.

Greenwich Biosciences, Inc.

Acadia Pharmaceuticals,

Janssen Neuroscience

Inc. Akcea Therapeutics

Lundbeck LLC

Alexion Pharmaceuticals,

Neurocrine Biosciences

Inc.

Novartis Gene Therapies

Allergan, Inc.

Novartis Pharmaceuticals

Corporation

Amgen

Sanofi Genzyme

Biogen

Sarepta Therapeutics

Biohaven Pharmaceuticals

Sunovion Pharmaceuticals

Eisai Inc.

Inc. Supernus Pharmaceuticals,

$25K Companies Abbott Adamas Pharmaceuticals,

Inc. Alnylam Pharmaceuticals, Amneal Specialty, a division

of Amneal Pharmaceuticals LLC Avanir Pharmaceuticals,

Inc.

Teva CNS

EMD Serono

Medtronic

AstraZeneca

Inc.

Eli Lilly & Co.

Horizon Therapeutics

Inc.

argenx

Bristol Myers Squibb

$40K Companies

Ovid Therapeutics SK life science, a subsidiary

of SK biopharmaceuticals UCB, Inc. Zogenix, Inc.

$10K Companies Audentes Therapeutics, an

Astellas company Axsome Therapeutics Boston Scientific Impel NeuroPharma nQ Medical, Inc. Orphazyme Revance Therapeutics

For more on the role of industry at the Annual Meeting, see page 36

Grifols

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Ultra-Simple. Ultra-Certain. The next generation of Natus neuromuscular diagnostics Trusted Software Natus Elite software powered by Viking or Synergy, compatible with existing Natus products

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Amplifiers 3-channel and 4-channel options

Amplifiers

Stimulator Probe Buttons Programmable for convenient key function control

Reference Values AANEM, pediatric, or customized reference values Control Panel Stimulation Probe

Visit us at the AAN Annual Meeting and ask about upgrade opportunities:

natus.com/ultrapro

Improved Integration Make fast, secure connection to patient EMR

Health Care Equity Symposium Debuts The AAN is firmly committed to embracing the diversity of our members, staff, organization, profession, and, ultimately, the patient communities we serve. To this end, the Academy will host its first Health Care Equity Symposium on Monday, April 19, from 1:00 p.m.–3:00 p.m. ET during the virtual 2021 Annual Meeting. The program will include the Cheryl A. Jay Keynote Lecture titled “Structural Equity: Lessons from 2020” by Vice President and Chief Equity and Inclusion Officer at Massachusetts General Hospital Joseph R. Betancourt, MD, MPH, on how to recognize disparities in care and help move towards health equity in neurology. Betancourt’s talk will be followed by an interactive panel discussion on how to recognize disparities in care and how to work towards Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS) in neurology practice and patient care. The discussion will conclude with a live Q&A with attendees. Cheryl A. Jay Keynote Lecture The Cheryl A. Jay Lectureship is supported by the Cheryl A. Jay Endowment Fund of the American Brain Foundation. STRUCTURAL EQUITY: LESSONS FROM 2020 Joseph R. Betancourt, MD, MPH Vice president and Chief Equity and Inclusion Officer and founder, senior advisor, and faculty of the Disparities Solutions Center, Massachusetts General Hospital Panel Members Richard T. Benson, MD, PhD

National Institute of Neurological Disorders and Stroke, National Institutes of Health; Director, Office of Global Health and Health Disparities

Nicte I. Mejia, MD, MPH, FAAN

Assistant Professor of Neurology, Harvard Medical School and Massachusetts General Hospital

Nicole Rosendale, MD

Assistant Professor of Neurology, University of California, San Francisco

Jeffrey C. McClean II, MD, FAAN

Lt. Col., United States Air Force, MC deputy chief, Brooke Army Medical Center Department of Medicine

Opportunities Abound to Connect and Engage at Networking/Entertainment Hub With its convenient, fully virtual format, connecting and networking with your neurology colleagues from anywhere on the globe has never been easier. Visit the Networking/Entertainment Hub for these opportunities throughout the Annual Meeting.

Networking Sessions Look for 45-minute opportunities, three times a day Saturday through Wednesday, and one session on Thursday, to enter casual virtual conversation rooms— each featuring a different topic or theme and offering video and chat capabilities. Topics include: How to Virtually Network at the Annual Meeting, Conversation with the AAN CEO, Telehealth Tips and Tricks, Charting Your Leadership Journey, The World of Advanced Practice Providers, and Current Trends Affecting Solo and Small Practice.

Public Chat Channels Engage in these AAN-created public chat channels on specific topics and areas of shared interest with fellow attendees within a virtual room—including video chat options!

Private Chat Channels Create your own chat channel and send personal invites to your colleagues to join in the completely private channel that can only be seen and accessed by host and invitees.

Direct Messaging Reach out directly to other Annual Meeting attendees for messaging or video within the virtual conference platform.

Twitter Wall Check out what your colleagues are saying about their aha moments on the Twitter wall. And don’t forget to share your experiences on your active social media platforms using #AANAM!

Photo Booth Take a selfie, personalize your photos with stickers, and quickly share on social media.

For more information, visit AAN.com/21AM. Sponsored by AAN Family of Publications, Neurology ® , Neurology ® Clinical Practice, Neurology ® Neuroimmunology & Neuroinflammation, Neurology ® Genetics, Continuum®, Neurology Today ® , and Brain & Life® with Wolters Kluwer Health, AAN Publishing Partner.

2021 Annual Meeting • AANextra

Latest Innovations of Significance Highlighted in Emerging Science Abstracts continued from the cover Abstract Title

Abstract Author

Results of Transpher A, a Multicenter, Single-Dose, Phase 1/2 Clinical Trial of ABO-102 Gene Therapy for Sanfilippo Syndrome Type A (Mucopolysaccharidosis IIIA)

Kevin M. Flanigan, MD, FAAN

Preliminary Results of Ongoing, Prospective Study of Antibody and T-cell Responses to SARS-CoV-2 in Patients with MS on Ocrelizumab or Other Disease-modifying Therapies

Ilya Kister, MD, FAAN

Comparison of Neurofilament Light and Total Tau as Blood-based Biomarkers of Neurodegeneration: Associations with Cognition and Neuroimaging Outcomes

Jordan Marks

African American Patients with MS/NMOSD Have More Rapid B-cell Repopulation than White Patients Following Infusion of Anti-CD20 B-cell Depleting Therapy

Lucia Saidenberg

The Effect of Evobrutinib, a BTK Inhibitor, on Blood Neurofilament Light Chain Levels in Relapsing Multiple Sclerosis

Jens Kuhle, MD

Neurological and Cardiac Improvements with PRX004 in Amyloidosis Patients: Results of a Phase 1 Study Ole Suhr Neurologic and Radiographic Findings Associated with Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) in Children

Omar Abdel-Mannan, MD

Association of COVID-19 Infections with Novel and Breakthrough Epileptic Seizures

Hardik Bhaskar

Optimization of AOC-1001, an Antibody-oligonucleotide Conjugate Targeting the Underlying Cause of Myotonic Dystrophy Type 1

Rob S. Burke, MD, FAAN

Stroke Complicating Critically Ill Patients with SARS-CoV-2: Analysis of the COVID-19 Critical Care Consortium (CCCC) International, Multicentre Observational Study

Jonathon Fanning, PhD, MBBS

Vagus Nerve Stimulation Paired with Upper Extremity Rehabilitation After Chronic Stroke: Cross-over results from the VNS-REHAB Pivotal Study

Jesse Dawson

Leriglitazone Improved Progression of Myelopathy-related Symptoms, and Reduced Cerebral Lesions in Reza Seyedsadjadi, MD Patients with Adrenomyeloneuropathy in a Phase 2/3 Clinical Study NCC: 20 Career Center Ad — Half Page Horizontal> AANextra FINTEPLA (Fenfluramine) Treatment Improves Everyday Executive Functioning in Patients with LennoxPlaced in AANextra Syndrome: Analysis From a Phase 3 Clinical Trial 8.25 x 4.25Gastaut +0.125 bleed, 4C

The American Academy of Neurology is proud to offer

THE #1 CAREER CENTER FOR NEUROLOGISTS FIND A JOB

RECRUIT TOP TALENT

Learn more! Careers.AAN.com

Kim I. Bishop, PhD

Your Prescription for Nightly Annual Meeting Entertainment We know the brain needs to relax and recharge after a full day of learning. That’s why each evening, we’re providing these fun events so you can kick back for some music, laughter, or culinary capers in your kitchen. Invite your family to get in on the fun, too!

Saturday, April 17 • 7:00 p.m.–8:00 p.m ET: Comedy Night with Jim Gaffigan Comedian, Actor, and Best-selling Author

Join us for an evening filled with the clean comedic brilliance of Jim Gaffigan on Saturday, April 17, from 7:00 p.m.–8:00 p.m. ET! A six-time Grammy nominated comedian, actor, writer, and producer, Gaffigan is known around the world for his unique brand of humor, which largely revolves around his observations on life. Touched by the life changes that came with his wife’s brain tumor diagnosis, Gaffigan is no stranger to the world of neurology. He’s also kept busy since the start of the COVID-19 pandemic with a new YouTube series “Dinner with the Gaffigans” about what quarantine has been like with five children. AAN Board Member and Meeting Management Committee Chair Carlayne E. Jackson, MD, FAAN, and Meeting Management Committee Vice Chair Maisha T. Robinson, MD, MS, FAAN, will interview Gaffigan on how humor can be found in the most unassuming places. This is sure to be an unforgettable evening, so mark your calendars for Saturday, April 17, from 7:00 p.m.–8:00 p.m. ET when Gaffigan will bring his wit and humor to the virtual 2021 AAN Annual Meeting stage.

Sunday, April 18 7:00 p.m.–8:00 p.m ET: Fun and Games Select from one of three popular entertainment and game night options: jaw-dropping sleightof-hand of magician Paul Draper, wacky comedy improv from The Second City Improv Comedy, and a brain-challenging trivia contest.

Monday, April 19 7:00 p.m.–8:00 p.m ET: Culinary Experiences Choose your adventure! We’ll have demos for cooking, beverage tasting, and a mixologist. Have a favorite? Visit AAN.com/21AM to learn more.

Tuesday, April 20 7:00 p.m.–8:00 p.m. ET: AAN Talent Show Attendees submitted their best talents to thrill and amaze you. Join us LIVE to watch the top submissions and VOTE on who you think is the most talented neurologist or neuroscience professional! The top three talents will be announced at the end of the show. Learn more at AAN.com/21AM.

2021 Annual Meeting • AANextra

Discover Why the AAN Is Indispensable at the AAN Showcase Make your way to the virtual AAN Showcase auditorum to discover all the career-enhancing products, tools, and resources that make the AAN indispensable to you. Look for interactive opportunities to engage and learn about:

Stop by the AAN membership booth to discover what’s new and get answers to all your membership questions. From membership applications or renewals, applying for FAAN status, engaging with Synapse Online Communities, or help navigating your member benefits, AAN membership staff will be available to assist in one-onone chat and video calls.

Get information on all of the AAN’s premier online education programs. Watch demo videos of NeuroBytes, Annual Meeting On Demand, and NeuroReady programs; learn more about Question of the Day and NeuroSAE; or chat or video call directly with AAN staff about any of the Academy’s online learning programs.

As the philanthropic partner of the AAN, the American Brain Foundation brings researchers and donors together to invest in research across the spectrum of brain disease. Stop by our booth to learn more about research grant opportunities, how you can help fund the next generation of clinical neuroscientists, and to sign up for our annual Commitment to Cures gala.

The AAN’s Axon Registry ® is a Quality Clinical Data Registry (QCDR) focused on quality improvement. It provides real-time access to your real-world data in an online dashboard for neurologyspecific measures. Your future depends on taking control of your data to improve quality of care and reduce costs. Use the Axon Registry to set your practice up for success.

Learn what’s new with Continuum®, the AAN’s official CME journal, and Continuum® Audio. Subscribe or renew today at a 15-percent discount (AAN members pay only $339 per year). Offer valid through June 30 at continpub.com/SpringSpecial.

Find a new job, participate in a Virtual Career Fair, and view helpful resources available to support a career move. Collect a copy of the Career Compass Job Guide and learn how to claim a free t-shirt!

Watch a short video describing the print and online features of the journal and the three spin-off journals launched during the past 10 years: Neurology: Clinical Practice, Neurology: Neuroimmunology & Neuroinflammation, and Neurology: Genetics. You will also find information on the journal’s Resident & Fellow section, the Neurology Podcast, journal and podcast CME opportunities, the interactive sites Practice Current and Practice Buzz, and the four specialty mini-sites: Without Borders; Equity, Diversity, & Inclusion; Innovations in Care Delivery; and COVID-19.

Inclusion, Diversity, Equity, Anti-racism, and Social Justice The need for equity and inclusiveness in health care has never been greater. The AAN is firmly committed to embracing Inclusion, Diversity, Equity, Anti-Racism, and Social Justice (IDEAS) for our members, staff, organization, profession, and, ultimately, the patient communities we serve. Learn more about AAN IDEAS initiatives and how we are putting our vision and mission into action.

Recognizing our Members The Annual Meeting and the Academy are thankful for the many members that help us plan and execute aspects of the Annual Meeting, sections, and more. Stop by this booth to see how your fellow members contribute to the Academy's successes.

Visit with BrainPAC, the political action committee affiliated with American Academy of Neurology. Learn how our political work helps the Academy fight for you and your patients, how you can get involved, or just come by to talk politics!

2021 Annual Meeting • AANextra

Upgrade to Gold Registration for Program Access Through March 31, 2022 Large shifts in the landscape of the health care industry have led to a gap between the skills that health care leaders possess and the skills their organizations need. This gap is largely felt by physician leaders whose medical education has traditionally focused on developing excellent clinical skills, but not the fundamental leadership skills needed to advance their organizations in this changing industry. Stop by to learn what resources the AAN has to offer you to further your leadership development.

2022 Annual Meeting in Seattle Seattle is getting ready to welcome you safely to the 2022 Annual Meeting, so stop by for a virtual taste of what’s in store for you in the Emerald City! From unrivaled natural beauty and world-class attractions to major sports teams, a renowned arts and culture scene, and more, Seattle is the perfect destination for both business and leisure.

For even more value from your 2021 AAN Annual Meeting registration, upgrade to the Virtual Gold Registration. While your regular registration offers access to courses for 30 days after the meeting ends, Virtual Gold Registration extends that time period through March 31, 2022, and offers exclusive access to additional courses with Annual Meeting On Demand. In addition to all of the benefits of regular registration, you’ll retain access to all meeting syllabi and virtual session recordings, CME, and receive more than 25 exclusive bonus sessions and presentations to round out this comprehensive digital reference library that’s accessible anytime, anywhere. Adding Annual Meeting On Demand to your registration now offers a significant savings from post-Annual Meeting pricing, so visit AAN.com/AMOD to upgrade today.

MEM: 20 Memebership Dues Ad—Half Page Horizontal> AN Placed in AANnews 8.25 x 5.25 +0.125 bleed, 4C

Renew today! AAN.com/Dues

it’s time to save Only AAN members can save on Annual Meeting registration. Not a member? Visit AAN.com/view/join to learn more

What They’re Saying About the Virtual 2021 Annual Meeting Natalia S. Rost, MD, MPH, FAAN, FAHA, Chair, Science Committee What is new and exciting about this year’s science program?

Maisha T. Robinson, MD, MS, FAAN, Vice Chair, Meeting Management Committee Why is the AAN’s Annual Meeting your “can’t miss” neurology meeting of the year? The Annual Meeting is an unparalleled experience in terms of professional meetings. There are hundreds of education courses and scientific sessions, as well as non-traditional learning platforms that are offered in fun and engaging settings. Each year, I look forward most to the interactions that the meeting facilitates between neurologists from across the US and from around the world. What are you most looking forward to for the 2021 Annual Meeting? Everything! I am beyond excited to see how the Academy builds on its previous meeting successes to provide much needed programming during an unusual time for all of us and in a novel manner. I’m sure it will be exciting, innovative, fresh, and informative. If you were speaking to an AAN member who hasn’t attended an Annual Meeting in five years, what would you say to convince them that 2021 is the year to attend? Over the past few years, the Academy has really pushed the boundaries of what a medical meeting can be. While still offering the traditional science and education sessions, the meeting has provided a host of alternative learning environments with diverse formats through the experiential learning areas, the inspirational talks, and the professional development opportunities.

2021 Annual Meeting • AANextra

It’s still a robust program, but to address the time demands of virtual programming, we trimmed the number of scientific sessions but kept all the key elements of the program—most importantly, the plenaries, Neuroscience in the Clinic, and the Invited Science Sessions are front and center as always. And it will address relevant and timely science related to neurological complications of COVID-19 and its effects on the field of neurology. We’ll also look at health disparities and the neurological sequelae of systemic racism. Last year has been one of the most intense and fast-moving in terms of the evolving health care environment and the unraveling manifestations of systemic racism, and I am extremely proud of the AAN Science Committee’s swift and unified response to address these issues through innovative programming. What are you most looking forward to for the 2021 Annual Meeting science program? The scientific plenary sessions remain my absolute favorite event and I hope that everyone joins us live in the virtual grand halls of the 2021 meeting for the plenaries. But I also don’t want to miss the original science–from the poster hall to the scientific platforms. We are so grateful for over 2,000 submissions we received despite all the challenges of the 2020, and I am looking forward to “browsing” the scientific sessions even if in the virtual space. How would you convince someone that 2021 is the year to attend? This 2021 Annual Meeting is my absolute “must-go” for at least three reasons: 1) nowhere else can one find a broader and more engaging, cutting-edge scientific program delivered in the most creative virtual way as at the #AANAM; 2) I’ll be able to reconnect with the awesome community of my colleagues and friends I missed dearly over the past year; and 3) I can “travel” to this meeting without leaving the comfort and safety of my home–that’s a bonus in these uncertain times and an unprecedented opportunity for so many to join a global neurological community!

Joseph I. Sirven, MD, FAAN, Chair, Conference Subcommittee; Vice Chair, Education Committee What is most exciting to you about a virtual format for education delivery? The most exciting aspect of a virtual format is the ability to be innovative in finding new ways to create a sense of community amongst us all neurologists. This still is the essence of all that we have offered in any given year when we meet in person, but this year we’re working to replicate this experience in a virtual environment from the comfort of your home. What are you most looking forward to for the 2021 Annual Meeting education program? I am looking forward to connecting and seeing all my neurology friends virtually. I am also excited about seeing some of the new HeadTalks that we have reinvented for the virtual format. I think it is going to connect our community in groundbreaking ways while presenting a comprehensive educational experience.

Teri Schreiner, MD, MPH, FAAN, Chair, Annual Meeting Networking and Engagement Work Group; Member, Meeting Management Committee What are you most looking forward to for the 2021 Annual Meeting? I am excited for a fun and accessible Annual Meeting program. As a parent to young children, I appreciate the opportunity to experience the excellent content of the #AANAM without leaving home—and the flexibility of a virtual platform that allows for greater live attendance and networking. In addition to the ability to easily connect with colleagues in a meaningful and effective way, I am also looking forward to the fun nightly events! What are some ways people can purposefully connect with one another? In-person networking can be random, but with the topicspecific sessions in this year’s Networking Hub, I will be more likely to make contact with colleagues with similar interests. I’m also looking forward to the opportunity to video chat on topic-specific chat channels and see which of my colleagues and friends from around the world are at the meeting using the World Map. These are just a few of the many convenient ways to network and engage this April. I look forward to catching up with you there!

Now Enrolling! Medicure is looking for physicians treating patients with confirmed Pyridoxamine 5’ Phosphate Oxidase (PNPO) deficiency that are currently receiving chronic treatment with oral Pyridoxal 5’ Phosphate (P5P) for enrollment in the MEND-PNPO clinical trial. The goal of MEND-PNPO is to evaluate the efficacy of an experimental pharmaceutical-grade P5P as a replacement therapy to unregulated supplement use. Patients qualify for the study if they: •

Have confirmed PNPO deficiency via genetic analysis (Medicure can provide assistance)

• Have their seizures typically controlled with daily oral P5P therapy •

Do not have a condition, abnormality or allergy that compromises their safety

• Are not on pyridoxine •

Are not involved in other clinical research studies (ongoing registries exempted)

For more study information, or to discuss enrollment of your patient, please contact us at medical.information@medicure.com or by phone at

1-800-509-0544

Congratulations 2021 AAN Award Winners! Congratulations to the winners of the 2021 AAN awards, who will be honored through the Awards Theater at the virtual Annual Meeting. The AAN thanks the American Brain Foundation for its support through philanthropy of the American Academy of Neurology's awards program.

EDUCATION AWARDS

A.B. Baker Award for Lifetime Achievement in Neurologic Education Funded by an endowment created by matching funds from the A.B. Baker Family Trust and Novartis Pharmaceuticals. John Engstrom, MD, FAAN, University of California San Francisco A.B. Baker Teacher Recognition Award Aman Deep, MD Professor of Neurology, Appalachian Regional Healthcare, Mount Hope, WV Andrew R. Romeo, MD University of Michigan, Ann Arbor, MI Anna M. Cervantes-Arslanian, MD Boston University School of Medicine, Boston Medical Center, Belmont, MA Aravindhan Veerapandiyan, MD Arkansas Children's Hospital / University of Arkansas for Medical Sciences, Little Rock, AR Arpan Patel, MD Northwell Health (North Shore University Hospital & Long Island Jewish Medical Center), Manhasset, New York

Jaime Toro, MD, FAAN, FACP Fundacion Santa Fe de Bogota, Bogota, Colombia James M. Noble, MD, MS, CPH, FAAN Columbia University, Demarest, NJ James Warne Schmidley, MD Virginia Tech Carilion School of Medicine, Roanoke, VA Jason S. Hawley, MD Walter Reed National Military Medical Center, Potomac, MD Jayne Ward, DO, FAAN, FACN Michigan State University, Dewitt, Michigan Jeffrey M. Gelfand, MD, MAS, FAAN University of California, San Francisco, Mill Valley, CA Jennifer A. McCombe, MD, MPH, FRCPC University of Alberta, Edmonton, AB Jeremy J. Laukka, PhD University of Toledo College of Medicine and Life Sciences, Brighton, MI

Barney J. Stern, MD Johns Hopkins University, Baltimore, MD

Joseph D. Burns, MD Lahey Hospital and Medical Center; Tufts University School of Medicine, Arlington, MA

Barry M. Czeisler, MD New York University Grossman School of Medicine, Brooklyn, NY

Kevin M. Kelly, MD, PhD Allegheny General Hospital, Allison Park, PA

Catherine E. Arnold, MD Mayo Clinic, Rochester, MN

Matthew Burford, MD Cedars-Sinai Medical Center, Los Angeles, CA

Chilvana Patel, MD University of Texas Medical Branch, Houston, TX

Geetanjali Rathore, MD University of Nebraska Medical Center, Omaha, NE

Christopher G. Tarolli, MD, MHPE University of Rochester, Pittsford, NY

Mostafa Meshref Al-Azhar University, Cairo, Egypt

Cynthia M. Correll, MD Geisinger Commonwealth School of Medicine, Bloomsburg, PA

Naoum P. Issa, MD, PhD University of Chicago, Chicago, IL

Danish Ejaz Bhatti, MD, FAAN University of Nebraska Medical Center, Elkhorn, NE

Nicole Chiota-McCollum, MD, MEd University of Virginia, Charlottesville, VA

David K. Chan, MD, Med University of Toronto, Toronto, Ontario

Nils Henninger, MD, PhD University of Massachusetts Medical School, Shrewsbury, MA

Dinesh V. Jillella, MD Emory University School of Medicine, Atlanta, GA

Preet M. Varade, MD Lehigh Valley Health Network, Center Valley, PA

Elliot Dimberg, MD Mayo Clinic, Jacksonville, FL

Pazhani Ranganathan, MD, DM, MRCP, FRCP, FEBN, FEAN, LLB Pazhani Neuro Centre/The Tamilnadu DR.M.G.R Medical University, Chennai, Tamil Nadu, India

Eric J. Seachrist, MD West Virginia University, Morgantown, WV

Fariha Jamal, MD Baylor College of Medicine/Michael E. DeBakey VA Medical Center, Pearland, TX

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Saad Abdul Sami Mir, MD Weill Cornell Medical College, Brooklyn, NY

Sean J. Evans, MD UC San Diego, La Jolla, CA Sudha Kilaru Kessler, MD, MSCE Children's Hospital of Philadelphia/University of Pennsylvania, Philadelphia, PA Susan W. Law, DO, MPH SUNY Downstate Medical Center, Brooklyn, NY Timothy Fullam, MD United States Air Force, Overland Park, KS Tuba Rashid Khan, MBBS, MPH, EdM University of Texas Southwestern Medical Center, Dallas, TX Victor W. Sung, MD University of Alabama at Birmingham, Vestavia, AL Waqar Waheed, MD University of Vermont Medical Center, Burlington, VT William J. Powers, MD University of North Carolina School of Medicine, Chapel Hill, North Carolina Zabeen Kaizar Mahuwala, MD University of Kentucky, Lexington, KY Association of Indian Neurologists in America Lifetime Achievement Award Sponsored by the Association of Indian Neurologists in America Fund of the American Brain Foundation. Seemant Chaturvedi, MD University of Maryland, Baltimore, MD Manmohan Nayyar, MD, FAAN, MBA, MHA Choice Medical Group, Apple Valley, CA Clerkship Coordinator Recognition Award Sheryll Marshall, Administrative Services Coordinator University of Michigan Clerkship Director Innovation Award Doris G. Leung, MD, PhD Johns Hopkins University School of Medicine M. Bernadette Clark Johns Hopkins University Madhu Soni, MD, FAAN Johns Hopkins University School of Medicine Consortium of Neurology Residents and Fellows Essay Contest Jonathan Williams, MD Washington University Frank A. Rubino Award for Excellence in Clinical Neurology Teaching Michael Schneck, MD Loyola University Chicago, Stritch School of Medicine

Residency-Fellowship Program Coordinator Recognition Award Jean Peng, MPH Mount Sanai Beth Israel Samantha Kunvatanagarn University of Pittsburgh's Medical Center Neurology Residency-Fellowship Program Director Recognition Award Chad Carlson, MD Medical College of Wisconsin Torrey Boland-Birch, MD Department of Neurological Sciences Rush University Medical Center Jeremy Moeller, MD, MSc, FRCPC Yale University Rebecca Fasano, MD Emory University

PATIENT SERVICE AWARDS

Ambassador Award Sponsored by the American Brain Foundation NFL Players Association Health and Safety Committee Commitment to Cures Award Sponsored by the American Brain Foundation Cindy McCain Mridha Spirit of Neurology Humanitarian Award Farrah Mateen, MD, PhD Massachusetts General Hospital / Harvard Medical School Deanna Saylor, MD, MHS Johns Hopkins University School of Medicine / University of Zambia School of Medicine / University Teaching Hospital Sanjay P. Singh, MD, FAAN, FANA Creighton University School of Medicine Public Leadership in Neurology Award Sponsored by the American Brain Foundation Sanjay Gupta, MD QI Innovation Award Mahjabin Islam, MBBS, MRCP; Ahmed Mubarak-Mohamed, MRCPE; Tom Jenkins, MBChB, MRCP, PhD; Christopher McDermott, MBChB, FRCP, PhD Royal Hallamshire Hospital, Sheffield, South Yorkshire, United Kingdom Scientific Breakthrough Award Sponsored by the American Brain Foundation. Peter Goadsby, MD, PhD Ted Burns Humanism in Neurology Award John Quinlan, MD University of Cincinnati Medical Center Continued on page 28 u

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Congratulations 2021 AAN Award Winners continued from page 27 ADVOCACY AWARD

2021 Kenneth M. Viste, Jr., MD, Patient Advocate of the Year Award E. Alexandra Brown, MD University of California, San Francisco, CA

SCIENTIFIC AWARDS

AAN Neuro-infectious Disease Award Sponsored by the American Academy of Neurology. Deanna Saylor, MD, MHS The Johns Hopkins University School of Medicine, Baltimore, MD Alliance Awards: Founders Sponsored by the American Academy of Neurology and endowed by the former American Academy of Neurology Alliance. Mehdi Bouslama, MD Emory University School of Medicine, Atlanta, GA Bruce S. Schoenberg International Award in Neuroepidemiology Sponsored by the American Academy of Neurology and endowed by GlaxoSmithKline, Inc. Guillermo Delgado-Garcia, MD, MSc University of Calgary, Calgary, Alberta, Canada Career Development Award Funded by the American Academy of Neurology. Jason Chua, MD, PhD University of Michigan, Ann Arbor, MI Julie Miller, MD, PhD Massachusetts General Hospital. Boston, MA Clinical Research Training Scholarship Funded by the American Academy of Neurology. Daniel Rubin, MD, PhD Massachusetts General Hospital, Boston, MA Yan Wang, MD Washington University in St. Louis, St. Louis, MO Samuel Snider, MD Brigham and Women's Hospital, Harvard Medical School, Boston, MA Clinical Research Training Scholarship in ALS Funded by The ALS Association and American Brain Foundation in collaboration with the American Academy of Neurology. Jonathan Brent, MD, PhD Feinberg School of Medicine, Northwestern University, Chicago, IL

2021 Annual Meeting • AANextra

Clinical Research Training Scholarship in ALS and Related Disorders Ikjae Lee, MD Columbia University Medical Center, New York, NY Clinical Research Training Scholarship in Neuromuscular Disease Funded by the Muscle Study Group and American Brain Foundation in collaboration with the American Academy of Neurology. Renatta Knox, MD, PhD Nationwide Children's, Columbus, OH Clinical Research Training Scholarship in Parkinson's Disease Funded by the Parkinson's Foundation and American Brain Foundation in collaboration with the American Academy of Neurology. Helen Hwang, MD, PhD Washington University in St. Louis, St. Louis, MO Dreifuss-Penry Epilepsy Award Sponsored by the American Academy of Neurology and endowed by members of the American Academy of Neurology Epilepsy Section; Abbott Laboratories, Inc.; Cephalon, Inc.; Cyberonics, Inc.; Elan Corporation; GlaxoSmithKline, Inc.; Novartis; Ortho-McNeil Pharmaceutical, Inc.; Pfizer Inc; Shire Pharmaceuticals Group; and UCB Pharma. Anli Liu, MD NYU Langone Health, New York, NY H. Richard Tyler Award Sponsored by the American Academy of Neurology and the American Academy of Neurology History Section. Michael Young, MD, MPhil MGH-BWH Harvard Medical School, Boston, MA Harold Wolff-John Graham Award: An Award for Headache/ Facial Pain Research Sponsored by the American Academy of Neurology and endowed by GlaxoSmithKline, Inc. Rebecca Erwin Wells, MD Wake Forest Baptist Medical Center, Winston Salem, NC Irwin Schatz Award for Autonomic Disorders Sponsored by the American Academy of Neurology and endowed by Lundbeck, Inc. Christopher Gibbons, MD, FAAN Harvard Medical School, Boston, MA

John Dystel Prize for Multiple Sclerosis Research Sponsored by the American Academy of Neurology and National Multiple Sclerosis Society and made possible through a special contribution from the John Dystel Multiple Sclerosis Research Fund at the National Multiple Sclerosis Society. Vijay Kuchroo, MD Brigham and Women's Hospital, Harvard Medical School, Boston, MA Jon Stolk Award in Movement Disorders for Young Investigators Sponsored by the American Academy of Neurology and endowed by Kyowa Pharmaceutical, Inc., Lineberry Research, Quintiles, Dr. Dennis Gillings, and VelaPharma. Ian Bledsoe, MD University of California, San Francisco, CA Lawrence C. McHenry: An Award for the History of Neurology Sponsored by the American Academy of Neurology. Bart Lutters, MD, MSc University Medical Center Utrecht, Utrecht, Netherlands McKnight Clinical Translational Research Scholarship in Cognitive Aging and Age-Related Memory Loss Funded by the McKnight Brain Research Foundation through the American Brain Foundation, and the American Academy of Neurology. Wai-Ying Yau, MD Massachusetts General Hospital, Brigham, Harvard, Boston, MA Matthew Burns, MD, PhD University of Florida College of Medicine–Neurology, Gainesville, FL Medical Student Essay Award: Extended Neuroscience Sponsored by the American Academy of Neurology. John Michael Sanchez, PhD University of Utah, Salt Lake City, UT Medical Student Essay Award: G. Milton Shy Sponsored by the American Academy of Neurology. Aparna Nutakki University of Chicago, Chicago, IL Medical Student Essay Awards: Roland P. Mackay Sponsored by the American Academy of Neurology. Duong Chu Queen's University, Kingston, Ontario, Canada Medical Student Essay Awards: Saul R. Korey Sponsored by the American Academy of Neurology.

Mitchell B. Max Neuropathic Pain Award Sponsored by the American Academy of Neurology and endowed by the United States Cancer Pain Relief Committee, the Mayday Fund, and friends of Dr. Mitchell Max. Stephen G. Waxman, MD, PhD, FAAN Yale School of Medicine, New Haven, CT Movement Disorders Research Award Sponsored by the American Academy of Neurology, the Parkinson’s Foundation, and the American Academy of Neurology Movement Disorders Section and endowed by the Parkinson’s Foundation. Roger Albin, MD University of Michigan, Ann Arbor, MI Neuro-oncology Investigator Award Sponsored by the American Academy of Neurology and supported by friends of Dr. Jerome Posner. Pratiti Bandopadhayay, MBBS, PhD Harvard Medical School, Boston, MA Neuro-oncology Scientific Award Sponsored by the American Academy of Neurology and supported by friends of Dr. WK Alfred Yung. Michelle Monje, MD, PhD Stanford University, Stanford, CA Neuroscience Research Prize Sponsored by the American Academy of Neurology. Noah Getz The Bronx High School of Science, New York, NY Danny Li Jericho Senior High School, Jerico, NY Viraj Mehta BASIS Scottsdale, Scottsdale, AZ Neuroscience Research Prize in Child Neurology Sponsored by the American Academy of Neurology and the Child Neurology Society. Meagan Ryan Ossining High School, Ossining, NY Norman Geschwind Prize in Behavioral Neurology Sponsored by the American Academy of Neurology and endowed through Dr. Geschwind’s family, friends, and colleagues; Pfizer Inc; and the Society for Behavioral and Cognitive Neurology. Hugo Botha, MD Mayo School of Graduate Medical Education, Rochester, MN

Abena Kwegyir-Aggrey and April Henry Penn State College of Medicine, Hershey, PA Michael S. Pessin Stroke Leadership Prize Sponsored by the American Academy of Neurology and endowed by Dr. Pessin’s family, friends, and colleagues. Guido Falcone, MD Yale School of Medicine, New Haven, CT Continued on page 30 u

2021 Annual Meeting • AANextra

Congratulations 2021 AAN Award Winners continued from page 29 Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases Sponsored by the American Academy of Neurology and the American Brain Foundation and funded through the philanthropy of the Potamkin family. Kenneth S. Kosik, MD University of California Neuroscience Research Institute, Santa Barbara, CA Giovanna Mallucci, MD, PhD University of Cambridge, UK Richard Olney Clinician Scientist Development Award in ALS Funded by The ALS Association and American Brain Foundation in collaboration with the American Academy of Neurology. Paul Sampognaro, MD University of California-San Francisco, San Francisco, CA Sheila Essey Award: An Award for ALS Research Sponsored by the American Academy of Neurology, the American Brain Foundation and the ALS Association and supported through the philanthropy of the Essey Family and the ALS Association. Jan Veldink, MD, PhD University Medical Center Utrecht, Utrecht, Netherlands Sleep Science Award Sponsored by the American Academy of Neurology and the American Academy of Neurology Sleep Section and endowed by Cephalon, Inc. Charlene Gamaldo, MD, FAAN Johns Hopkins University, Baltimore, MD Susan S. Spencer, MD, Clinical Research Training Scholarship in Epilepsy Funded by the American Epilepsy Society, Epilepsy Foundation, and American Brain Foundation in collaboration with the American Academy of Neurology. Samuel Terman, MD University of Michigan, Ann Arbor, MI

SCHOLARSHIPS

International Scholarship Award Sponsored by the American Academy of Neurology. Gianmarco Abbadessa, MD University of Campania Liugi Vanvitelli, Naples, Italy Ifeyinwa Ani-Osheku, MBBS Asokoro District Hospital, Asokoro, Abuju, Nigeria Luca Baldelli, MD University of Bologna, Bologna, Italy Hanna Demissie Belay, MD Addis Ababa University, Addis Ababa, Ethiopia Rok Berlot, MD, PhD University Medical Centre Ljubjana, Ljubjana, Slovenia

2021 Annual Meeting • AANextra

Mashina Chomba, MBChB University Teaching Hospital, Lusaka, Zambia Marcelo de Brito, MD University of Sao Paulo Medical School, Sao Paulo, Brazil Daniela Laura Giardino, MD CEMIC, Buenos Aires, Argentina Mar Guasp, MD Hospital Clinic Barcelona, Barcelona, Calalunya, Spain Katrina Hannah Ignacio, MD Philippines General Hospital, Manilla, Philippines Moises Misael Rubio Hernandez, MD Zapopan, Jalisco, Mexico Ummugulsum Koc MD, Bochum, Germany Anand Kumar, DM Institute of Medical Sciences BHU, Varanasi, Uttar Pradesh, India Durjoy Lahiri, MD, DM Bangur Institute of Neurosciences, Kolkata, India Shanglin Li, MD Peking Union Medical Hospital, Beijing, China Jingyi Liu, MD Peking Union Medical Hospital, Beijing, China Amina Mohamed, MD Moi University School of Medicine, Eldoret, Uasin Gishu, Kenya Gabriel Pinilla Monsalve Fundacion Valle del Lili, Cali, Colombia Amina Nasri, MD Razi University Hospital, Tunis, Tunisia Samir Patel, MD, DNB KD Hospital, Ahmedabad, Gujarat, India Hebatallah Rashed, MD, PhD Ain Ahams University, Cairo, Egypt Mario Ricciardi, MD Fleni, Buenos Aires, Argentina Lokesh Saini, DM Advanced Pediatric Centre, PGIMER Chandigarh, Chandigarh, India Laura Sander, MD Universitätsspital Basel, Basel, Switzerland Raul Anwar Garcia Santos, MD Mexico City, Mexico Yi Shen, MD First Affiliated Hospital Zhejiang University, Zhejiang, China Mei-Jun Shu, MD Beijing, China

Duncan Street, MBBS, MRCP Birmingham, West Midlands, United Kingdom Ya Su, MD Huashan Hospital Fudan University, Shanghai, China Naohiro Uchio, MD, PhD Mitui Memorial Hospital, Tokyo, Japan Maria Agustina Ruiz Yanzi, MD Buenos Aires, Argentina

Frederike Cosima Oertel, MD University of California, San Francisco, San Francisco, CA Practice Research Training Scholarship Funded by the American Academy of Neurology. Altaf Saadi, MD Massachusetts General Hospital, Brigham, Harvard, Boston, MA Resident Research Scholarship Funded by the American Academy of Neurology

Garik Yeganyan, MD Vanadzor Medical Center, Vanadzor, Armenia

Aditi Varma-Doyle, MD LSU Health New Orleans, New Orleans, LA

Gulshan Yunisova, MD Istanbul Faculty of Medicine, Istanbul, Turkey

Elizabeth Harrison, MD UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA

Nisa Voarasoot, MD Khon Kaen University, Khon Kaen, Thailand

Linda Nyugen, MD, PhD University of California, San Diego/Rady Children's Hospital, San Diego, CA

Ramdinal Aviesena Zairinal, MD Depok Gyeonggi-do, Indonesia Neuroscience Research Training Scholarship Funded by the American Academy of Neurology. Emily Ferenczi, MD, PhD Massachusetts General Hospital, Brigham, Harvard, Boston, MA

Anti-amyloid Therapy for Alzheimer’s Disease, Real-world Considerations Covered in New Course With anti-amyloid therapy for Alzheimer’s disease being reviewed for potential approval by the Food and Drug Administration, many questions have arisen. Join in for this “Hot Topics in Clinical Practice” course for a discussion of the topic. The session is Monday, April 19, from 6:00 p.m. to 7:00 p.m. ET. Yu

Coerver

Neurology Today Reports on Science at Annual Meeting The AAN’s Neurology Today ® will be reporting daily on science at the virtual AAN Annual Meeting. Neurology Today At the Meetings keeps neurologists current and fully informed about the most noteworthy news from major professional meetings. Annual Meeting stories will be emailed to you daily from April 20 to 23. Watch your email inbox, follow the news on Twitter @NeurologyToday, or visit bit.ly/NT-ATMAAN during the meeting to check out the most recent coverage.

Led by Melissa Yu, MD, FAAN, the session will review mechanics of how amyloid therapy is given, how might patients be selected, APOE considerations, what is ARIA (amyloid-related imaging abnormalities), and how to manage. Yu and Katherine Coerver, MD, PhD, will cover the mechanisms of action of these therapies, as well as clinical trial data, allowing time for a live Q&A session with attendees.

This course complements the talk “Should Amyloid Continue to Be Targeted in Alzheimer’s?” during the Controversies in Neurology Plenary Session on Wednesday, April 21.

2021 Annual Meeting • AANextra

Industry Therapeutic Update from Horizon Therapeutics

B Cell Biology In Myasthenia Gravis: From Pathogenesis To Targeted Therapies

American Academy of Neurology 2021 Virtual Annual Meeting Wednesday, April 21, 2021, 9-10 a.m. ET B cells in immune-mediated neurological diseases Amit Bar-Or, MD, FRCPC University of Pennsylvania, Pennsylvania, USA

Diverse mechanisms of B cell-mediated autoimmunity in myasthenia gravis Kevin C. O’Connor, PhD Yale School of Medicine, Connecticut, USA

Targeted therapies in myasthenia gravis Richard J. Nowak, MD Yale School of Medicine, Connecticut, USA

This is not a part of the AAN Annual Meeting official programming and no CME will be given for attendance.

Viela Bio is now part of Horizon. horizontherapeutics.com

MED-US-INEB-2100037

Busis, Cascino to Receive President’s Awards During Annual Meeting Because of the cancellation of last year’s Annual Meeting, two stalwart leaders in neurology will receive the AAN President’s Award during the Presidential Plenary Session at the Annual Meeting on Sunday, April 18. Individuals honored by this award are selected by the AAN president for exemplary services to neurology. Both recipients are being honored by AAN President James C. Stevens, MD, FAAN. “It gives me immense personal pleasure to announce the recipient of the 2021 President’s Award, Dr. Neil Busis,” Stevens said. “Dr. Busis has served the AAN in a variety of roles over his greater than 25-year involvement with the organization. He has served on numerous committees, subcommittees, task forces, and work groups, most notably as chair of the Medical Economics and Management Committee, vice chair of our Health Policy Subcommittee, member of the AAN Wellness Joint Coordinating Council, as an advisor to the AMA CPT group, and has served several terms on the AAN Board of Directors. He has given untold number of lectures, webinars, and podcasts concerning practice issues involving coding and billing, telehealth, electronic health records, and physician wellness and burnout. He is a clinical professor of neurology at both the University of Pittsburgh Medical Center and the New York University Grossman School of Medicine. He has served nationally as a past-president of the American Academy of Electrodiagnostic Medicine and as a member of the National Academy of Medicine writing group for the consensus statement concerning physician burnout and well-being. He has served as an educator in both the private practice setting and in his current position within an academic center. He has long been recognized as the AAN content expert on coding and billing, in electrodiagnostic medicine, telehealth, electronic health records, and physician well-being. A true tour de force of accomplishments reflecting his love and dedication to our profession and to our organization. Congratulations, Dr. Busis!” Busis responded to the award, saying, “Thank you very much for this wonderful and totally unexpected honor. I am only one of thousands of volunteers who have contributed to the American Academy of Neurology since its founding. Supporting practice, research, education to enhance the care of patients with neurologic disorders has been our guiding principle. When I joined the AAN as a resident in 1982, there were only about 7,300 members. Today there are more than 36,000. The current breadth, depth, and creativity of the Academy’s activities is responsible for that increase in membership. The advances reflected in today’s programs would inspire awe in a member in 1982. We have found our collective voice with legislators and regulators in Washington, DC, state houses, and with private payers. We have supported ground-breaking research, including studies which assist evidence-based policy and advocacy. Our innovative educational offerings have improved how we teach and how we learn. We promote work-life integration and member well-being. Like many others, I found professional and personal fulfillment through my service to the Academy and engagement with my colleagues. Over time, these relationships developed into a community that I consider my ‘AAN family.’ To the extent I helped make a difference for our patients and our specialty, I consider myself fortunate to be in the right place at the right time. Past success is prologue to future success. As long as the AAN works to be indispensable to its members—which is the best statement of purpose of any organization I know—the AAN’s future is bright.”

Busis

Cascino

Gregory D. Cascino, MD, FAAN, of the Mayo Clinic, who was named recipient of the 2020 AAN President’s Award, also will be recognized during this year’s Presidential Plenary Session. Cascino was chosen by Stevens last year because of his leadership as chair of the Member Engagement Committee and the Academy’s success in attaining a record number of members. “It is my great pleasure to announce Dr. Greg Cascino as the 2020 recipient of the AAN President’s Award,” said Stevens in a statement last year. “A renowned epileptologist from the Mayo Clinic, Dr. Cascino has admirably served the AAN in various capacities over the past two decades. Known for his boundless energy and enthusiasm, he has been one of our organization’s most effective ambassadors during his many trips abroad as an invited speaker. He has served as the inaugural chair of our Membership Engagement Committee; his visionary leadership has resulted in the exponential growth and retention of our membership that has become the envy of all non-profit medical societies. He has served as a dedicated long-time associate editor of our premier journal Neurology, extending his term well beyond expectations. The AAN will be forever indebted for the selfless, tireless service we have received from Dr. Cascino, a neurologist so deserving of this recognition.” Cascino responded, “I am honored and delighted to be named the recipient of the 2020 President’s Award. Serving the needs of our AAN members has been a tremendous and unique privilege in my professional career. I would like to thank the many AAN staff and my ‘teammates’ on the Member Engagement Committee and the Board of Directors who have made this an enduring and gratifying experience.”

2021 Annual Meeting • AANextra

2020 Annual Report Captures Successes of Challenging Year It’s a year we may wish to put behind us, but to not read the 2020 Annual Report would be to miss out on how the Academy overcame extraordinary obstacles to end the year stronger and with more members than ever before. “2020 was a year like no other in the AAN’s history,” said President James C. Stevens, MD, FAAN. “Against a turbulent pandemic that endangered the health and welfare of our members and their patients, the Academy did everything it could to support your delivery of high-quality health care and increase the value of your membership. Virtual conferencing and added online education resources helped you continue to stay current with your skills. Our advocacy successes improved reimbursements, strengthened telehealth, increased research support, and helped ensure neurologists had the tools needed to confront the COVID-19 epidemic. The Academy publicly declared itself an antiracist organization and recommitted to a proven track record of promoting inclusion, diversity, equity, anti-racism, and social justice. All of this and more is captured in this report to members.”

Engage with Industry, Discover Latest Products at the Virtual Exhibit Hall Visit the engaging and dynamic virtual Exhibit Hall to explore the latest products available to help improve your service to patients. The area will be open throughout the meeting and the virtual conference platform will allow attendees to have engaging conversations with industry representatives. You can also visit the Industry Therapeutic Updates auditorium from the lobby to hear thought leaders present on current and pipeline therapies. Highlights for the Exhibit Hall and Industry Therapeutic Updates include: Connect with other health organizations Discover and learn about emerging technologies Keep up to date on what’s new in the neurology community Gather career resources Preview the latest products and services available to help

improve patient care Learn more at AAN.com/21AM

Visit AAN.com/AnnualReport to read how the AAN’s actions had DEP: YY(Project Name) Ad—Half Page Horizontal> NJ, NCPin record membership a positive impact for neurologists, resulting Placed innumbers Neurologyby Journal, or Neurology Clinical Practice the end of the year. 8.25 x 5.4375 +0.125 bleed, 4C

Access the 2021 Annual Meeting Anytime, Anywhere Upgrade to Virtual Gold registration and retain access with 2021 Annual Meeting On Demand, which includes: ■ More than 300 hours of content ■ 140+ programs with syllabi from the live virtual meeting ■ 25+ exclusive bonus presentations to round out this comprehensive digital reference library ■ Integrated CME testing, with ability to claim CME through March 31, 2022

Upgrade now at AAN.com/AMOD

Thank You

2O21 Industry Roundtable Members* The American Academy of Neurology and the Industry Roundtable collaborate on opportunities to support neurology and serve patients with neurologic disease.

$50,000 Members

$40,000 Members

$25,000 Members

• Horizon Therapeutics

• AstraZeneca

• Grifols

• Audentes Therapeutics, an Astellas company

• Medtronic

• Abbott

• Ovid Therapeutics

• Axsome Therapeutics

• Adamas Pharmaceuticals, Inc.

• SK life science, a subsidiary

• Boston Scientific

• Alnylam Pharmaceuticals, Inc. • Amneal Specialty, a division of

Amneal Pharmaceuticals LLC • Avanir Pharmaceuticals, Inc.

$10,000 Members of SK biopharmaceuticals • UCB, Inc. • Zogenix, Inc.

• Impel NeuroPharma • nQ Medical, Inc. • Orphazyme • Revance Therapeutics

*Commitments as of March 19, 2021

Optimize Your Virtual Annual Meeting Experience with These Features Make the most of your virtual Annual Meeting experience with these helpful features in both the meeting’s virtual platform and the AAN Conferences Mobile App. Annual Meeting Virtual Platform This is your one-stop shop for experiencing the Annual Meeting— and we recommend a computer for optimal viewing. Simply log in using your email or six-digit member ID and password to start exploring these fun and informative features. From the lobby, access the Welcome Video, Today's Education Courses, Today's Scientific Courses, Today's Plenary Session, Experiential Learning Areas, Posters, AAN Rewind, Exhibits, Industry Therapeutic Updates, Networking/Entertainment Hub, Awards Theater, AAN Showcase, and Main Menu.

AAN Conferences Mobile App Simply visit the App Store or Google Play to download, then log in using your email or six-digit member ID and password to: Add your interests to your profile to get tailored

program recommendations Build your personalized agenda and get reminders

five minutes before your scheduled sessions Watch select sessions live (recommended for

tablets only for the best viewing experience) Access program materials, submit your program

evaluations, and claim CME Turn on push notifications to get helpful reminders

and tips throughout the Annual Meeting Filter by specially curated program tracks to help

find sessions most relevant to you Discover Annual Meeting highlights and can’t-miss events Read what’s being said at the Annual Meeting and join

the conversation using #AANAM on Facebook, Twitter, Instagram, and LinkedIn

Industry and the AAN Annual Meeting: Focusing on the Patient In his role as physician liaison to industry for the AAN’s Industry Roundtable (IRT), Jonathan P. Hosey, MD, FAAN, has been responsible for creating, expanding, and sustaining industry support in neurology; fostering positive engagement; and ensuring effective communication between industry and the AAN. Although focused on all industry interactions, much of Hosey’s work Hosey has been with IRT member companies seeking to engage and deepen their relationships with the AAN and their mutual focus on patients. “Over six-plus years, it has been enlightening and a pleasure to communicate observations, information, requests, and ideas between industry and AAN leaders and members,” said Hosey, who will be serving in his role for one final AAN Annual Meeting this April. “Transparency has been at the foundation and I would like to highlight some of the important things I have learned in this role— and how we all might benefit from industry’s involvement at this year’s virtual Annual Meeting.” AAN and Industry Share a Common Mission “First and foremost, I have learned in more than 75 individual meetings with IRT members that industry shares the AAN’s mission to promote the highest quality patient-centered neurologic care,” explained Hosey. “This does not mean we pursue this mission in the same way or have no conflicting interests, but with transparent dialogue we can learn a lot from each other, especially as we work toward common goals. I sincerely believe that learning more about

2021 Annual Meeting • AANextra

industry’s resources can add value to members’ Annual Meeting experience and to their roles treating patients with neurologic conditions.” Dialogue Is Important “In nearly every conversation I have had with individual companies, they ask ‘What more can we do to support the AAN?’ At the Annual Meeting, industry is looking for what they can do to support the needs of neurology and individual health care providers. They learn this through dialogue with attendees, from me as their liaison, and from staff. But it all begins with conversation. There are multiple ways to start the conversation, including visiting the virtual booths, asking specific questions, and taking part in the networking sessions—and I encourage all meeting attendees to participate.” Industry Has Valuable Information to Share Education and sharing of resources are at the core of industry’s participation at the meeting, according to Hosey. “In addition to learning in the Virtual Exhibit Experience, attendees can also gain knowledge about research, technologies, and promising pipelines through industry presentations via scientific posters and platforms, career exploration, and Industry Therapeutic Updates.” Added Hosey, “To industry, please accept my sincere thank you for the financial, research, and educational resources you share at this meeting to help us better serve the neurology profession—and our patients. To attendees, I encourage you to explore new venues for learning and expand the ways you interact with industry during this unique virtual meeting—delivered unconventionally.” Learn more about the IRT on page 18 of this issue of AANextra.

INDUSTRY THERAPEUTIC UPDATES

Join industry representatives live for unique opportunities to learn about current therapies and projects in the industry pipeline. The availability of these updates after the Annual Meeting is contingent upon regulatory requirements, so you are encouraged to attend these live events. You can also visit AAN.com/ITU for the most current schedule of Industry Therapeutic Updates. SATURDAY • APRIL 17 Acadia Pharmaceuticals, Inc. 1:00 p.m.–2:00 p.m. ET

MONDAY • APRIL 19 Sanofi Genzyme 9:00 a.m.–10:00 a.m. ET

TUESDAY • APRIL 20 Abbott 9:00 a.m.–10:00 a.m. ET

EMD Serono, Inc. 1:00 p.m.–2:00 p.m. ET

Sunovion Pharmaceuticals, Inc. 9:00 a.m.–10:00 a.m. ET

AstraZeneca 9:00 a.m.–10:00 a.m. ET

Novartis Pharmaceuticals, Inc. 1:00 p.m.–2:00 p.m. ET

Teva CNS 9:00 a.m.–10:00 a.m. ET

UCB, Inc. 9:00 a.m.–10:00 a.m. ET

SUNDAY • APRIL 18 Biogen 9:00 a.m.–10:00 a.m. ET

Biogen 1:00 p.m.–2:00 p.m. ET

Impel NeuroPharma 1:00 p.m.–2:00 p.m. ET

Biogen 1:00 p.m.–2:00 p.m. ET

Novartis Pharmaceuticals, Inc. 1:00 p.m.–2:00 p.m. ET

Lundbeck 1:00 p.m.–2:00 p.m. ET

Horizon Therapeutics 1:00 p.m.–2:00 p.m.v

argenx 7:00 p.m.–8:00 p.m. ET

Ackea Therapeutics 7:00 p.m.–8:00 p.m. ET

Greenwich Biosciences, Inc. 7:00 p.m.–8:00 p.m. ET

Genentech, a member of the Roche group 7:00 p.m.–8:00 p.m. ET

Biohaven Pharmaceuticals 9:00 a.m.–10:00 a.m. ET Sunovion Pharmaceuticals, Inc. 9:00 a.m.–10:00 a.m. ET AbbVie, Inc. 1:00 p.m.–2:00 p.m. ET Bristol Myers Squibb 1:00 p.m.–2:00 p.m. ET Sanofi Genzyme 1:00 p.m.–2:00 p.m. ET

Janssen Neuroscience 7:00 p.m.–8:00 p.m. ET

Alexion Pharmaceuticals, Inc. 7:00 p.m.–8:00 p.m. ET Sarepta Therapeutics 7:00 p.m.–8:00 p.m. ET Genentech, a member of the Roche group 7:00 p.m.–8:00 p.m. ET No CME will be given by any accredited organization for the Industry Therapeutic Updates, and the AAN cannot affirm claims pertaining to FDA off-label medication, research use of pre-FDA drugs, or other research information that might be discussed. Industry Therapeutic Updates are industry events.

nQ Medical, Inc. 7:00 p.m.–8:00 p.m. ET WEDNESDAY • APRIL 21 Horizon Therapeutics 9:00 a.m.–10:00 a.m. ET Adamas Pharmaceuticals, Inc. 1:00 p.m.–2:00 p.m. ET

Don’t Miss These Upcoming AAN Conferences

SPORTS CONCUSSION VIRTUAL CONFERENCE Virtual 2021 Sports Concussion Conference July 30–31, 2021

Discover the latest scientific advances and best practices for the prevention, diagnosis, and treatment of sports-related concussion from youth on up to professional levels. Learn more at AAN.com/SCC.

Virtual 2021 Advanced Practice Provider Neurology Education Series Date: to be announced

Back by popular demand, this self-paced, virtual education series, created by physicians specifically for advanced practice providers, is back, offering overviews, updates, and resources on a variety of core topics in neurology and the opportunity to earn CME. Watch for announcements on AAN.com.

Spanish-language Courses to Cover COVID, Headache, Neuroimmunology of Cancer Four courses at the 2021 Annual Meeting will be taught entirely in Spanish, including two courses specifically on COVID-19, one of which will feature a panel discussion offering differing viewpoints on the pandemic and neurology from other Spanish-speaking countries. All four programs will offer opportunities for Q&A with presenters and/or panelists, and there will be two opportunities for Spanish-speaking attendees to take part in video chat networking sessions.

Merino

“I am very excited about the Spanish-language program at this year’s Annual Meeting,” said José G. Merino, MD, MPhil, FAAN, chair of the Spanish Language Work Group. “An outstanding team of neurologists worked together to develop a program that will review some of the major advances in clinical neurology in the past year.” Offerings include: Manifestaciones Neurológicas de la infección por

2021 Fall Conference

Covid-19 (Neurological Manifestations of COVID-19) Sunday, April 18, 2:00 p.m.–3:00 p.m. ET Director: Alejandro Tobon, MD

Date: to be announced

Networking Session: Desmoralización de los servicios

Get the latest updates in neurology and practice management from expert faculty—plus valuable end-of-year CME. Stay tuned at AAN.com for more information.

Panel de Debate: Neurología y COVID en el Mundo

Annual Meeting 2022 Annual Meeting April 2–April 8, 2022 Seattle, WA

Be sure to stop by the AAN Showcase for information about the 2022 Annual Meeting in Seattle.

sanitarios. ”La segunda pandemia” Sunday, April 18, 3:00 p.m.–3:45 p.m. ET

Hispanohablante (COVID-19 Panel Discussion: Neurology and COVID in the Spanish-speaking World) Sunday, April 18, 4:00 p.m.–5:00 p.m. ET Director: Susana M. Bowling, MD

Actualización en Dolores de Cabeza (Headache Update)

Monday, April 19, 2:00 p.m.–3:00 p.m. ET Director: Clarimar Borrero-Mejias, MD

Networking Session: Cómo participar en la Resident &

Fellow Section de Neurology ® Tuesday, April 20, 9:00 a.m.–9:45 a.m. ET

Actualización en la Neuro-inmunología de Cáncer

(Neuroimmunology of Cancer Update) Tuesday, April 20, 6:00 p.m.–7:00 p.m. ET Director: Yazmin Odia, MD, FAAN, MS

Added Merino, “The continued support of the AAN for the Spanishlanguage program highlights the value placed by the Academy in building bridges with the international neurological community.”

2021 Annual Meeting • AANextra

Neurology

at The Mount Sinai Hospital, New York City

The Mount Sinai Hospital, New York City • Ranked #12 in the U.S. for Neurology and Neurosurgery by U.S. News & World Report, 2020

• Voted #6 in the U.S. and #19 in Neurology in the World by Newsweek’s “Best Specialty Hospitals,” 2021 • The Mount Sinai Hospital established the first-of-its-kind Center for Post-COVID Care in New York Ciity.

https://www.mountsinai.org/care/neurology

Wednesday, April 21, 2021 • 8-9pm ET

Sanjay Gupta, MD Public Leadership in Neurology Award

Cindy McCain Commitment to Cures Award

Alex Newell Musical Performer

Jim Cramer Master of Ceremonies

Matt Hasselbeck NFL Football Star

GET READY FOR A STAR-STUDDED EVENT. Don’t miss out on Commitment to Cures, a virtual event dedicated to celebrating and supporting advances in brain disease research. The evening will feature celebrity guests, a musical performance by Grammy-nominated singer and songwriter Alex Newell, a craft cocktail demo, inspiring stories from those impacted by brain disease, and more! And don’t forget to purchase your raffle ticket for a chance to win a getaway in Tuscany! Register now at americanbrainfoundation.org/C2C2021